Plume Dynamics Structure the Spatiotemporal Activity of Mitral/Tufted Cell Networks in the Mouse Olfactory Bulb
ORIGINAL RESEARCH published: 30 April 2021 doi: 10.3389/fncel.2021.633757 Plume Dynamics Structure the Spatiotemporal Activity of Mitral/Tufted Cell Networks in the Mouse Olfactory Bulb Suzanne M. Lewis 1*, Lai Xu 1, Nicola Rigolli 2,3, Mohammad F. Tariq 4, Lucas M. Suarez 1, Merav Stern 5, Agnese Seminara 3 and David H. Gire 1* 1 Department of Psychology, University of Washington, Seattle, WA, United States, 2 Dipartimento di Fisica, Istituto Nazionale Fisica Nucleare (INFN) Genova, Universitá di Genova, Genova, Italy, 3 CNRS, Institut de Physique de Nice, Université Côte d’Azur, Nice, France, 4 Graduate Program in Neuroscience, University of Washington, Seattle, WA, United States, 5 Department of Applied Mathematics, University of Washington, Seattle, WA, United States Although mice locate resources using turbulent airborne odor plumes, the stochasticity and intermittency of fluctuating plumes create challenges for interpreting odor cues in natural environments. Population activity within the olfactory bulb (OB) is thought to process this complex spatial and temporal information, but how plume dynamics Edited by: impact odor representation in this early stage of the mouse olfactory system is unknown. Shaina M. Short, The University of Utah, United States Limitations in odor detection technology have made it difficult to measure plume Reviewed by: fluctuations while simultaneously recording from the mouse’s brain. Thus, previous Andreas Schaefer, studies have measured OB activity following controlled odor pulses of varying profiles or Francis Crick Institute and University frequencies, but this approach only captures a subset of features found within olfactory College London, London, United Kingdom plumes. Adequately sampling this feature space is difficult given a lack of knowledge Shawn Denver Burton, regarding which features the brain extracts during exposure to natural olfactory scenes.
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