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(12) Patent Application Publication (10) Pub. No.: US 2011/0008457 A1 NEWMAN Et Al

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(12) Patent Application Publication (10) Pub. No.: US 2011/0008457 A1 NEWMAN Et Al US 2011 0008457A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2011/0008457 A1 NEWMAN et al. (43) Pub. Date: Jan. 13, 2011 (54) COMPOSITIONS AND METHODS FOR Publication Classification MODULATING LIPID COMPOSITION (51) Int. Cl. (75) Inventors: Robert A. NEWMAN, Surry, ME A6II 35/60 (2006.01) (US); Peiying YANG, Sugar Land, CIIB 5/00 (2006.01) TX (US); Paul SCHULICK, A6IP35/04 (2006.01) Brattleboro, VT (US) A6IP35/00 (2006.01) A6IP3/00 (2006.01) Correspondence Address: THE NATH LAW GROUP (52) U.S. Cl. ............................................. 424/523: 554/2 112 South West Street Alexandria, VA 22314 (US) (57) ABSTRACT (73) Assignees: NEW CHAPTER INC., Brattleboro, VT (US); BOARD OF The present subject matter relates to a novel herbal and oil REGENTS OF THE composition and methods for modulating fatty acid compo UNIVERSITY OF TEXAS sition and metabolism in an animal. In one aspect, the Subject SYSTEM, Austin, TX (US) matter involves a composition comprising rosemary extract, oregano extract, and a polyunsaturated oil. In a particular (21) Appl. No.: 12/790,533 embodiment, the polyunsaturated oil is fish oil or a derivative thereof. In some embodiments, the present Subject matter (22) Filed: May 28, 2010 relates to methods for modulating essential dietary fatty acid O O composition of lipoprotein particles or cell membranes, Related U.S. Application Data modulating essential fatty acid metabolism, regulating the (60) Provisional application No. 61/213,334, filed on May activity of lipoxygenases and cyclooxygenases, improving 29, 2009, provisional application No. 61/272,130, cardiovascular health, and/or inhibiting cell proliferation dis filed on Aug. 19, 2009. eases and disorders. Patent Application Publication Jan. 13, 2011 Sheet 1 of 22 US 2011/00084.57 A1 S s e is CD CD is st - - S O O T. T. e st do do on S Cd od S- cal go do go 9. & SS S cin cin cin (W/6n) Wid WNYS Patent Application Publication Jan. 13, 2011 Sheet 2 of 22 US 2011/00084.57 A1 GZOZ9||0||9 WOENETOHM40(6?)BSOQETONSWHELHW(I?)EN|| 07 98 08 OZ Patent Application Publication Jan. 13, 2011 Sheet 3 of 22 US 2011/00084.57 A1 CHANGE INCELL (PBMC) MEMBRANE CONTENT OF OMEGA-3LIPIDS AFTER CONSUMPTION OF WHOLEMEGA (2g) 25 BASELINE WHOLEMEGA 35% INCREASE 29% INCREASE O EPA DHA CHANGE INCELL (PBMC) MEMBRANE CONTENT OF OMEGA-7 AND9LIPIDS AFTER CONSUMPTION OF WHOLEMEGA (2g) 30 25- DBASELINE t ... WHOLEMEGA 41% INCREASE C d is, 28% INCREASE 2 15 D 10 5 5 O PALMITOLEICACD OLEIC ACID FIG 3 Patent Application Publication Jan. 13, 2011 Sheet 4 of 22 US 2011/00084.57 A1 INNOOWNWWS Patent Application Publication Jan. 13, 2011 Sheet 5 of 22 US 2011/00084.57 A1 W0EWETOHM|| WWW INIS Patent Application Publication Jan. 13, 2011 Sheet 6 of 22 US 2011/00084.57 A1 REPRESENTATIVE REDUCTIONS IN PBMC AA/EPARATIOS INTHREE HUMAN SUBJECTS CONSUMING 2g WHOLEMEGA 60 50 CC CD 40 L D L - 30 O C S 20 10 FIG. 6 Patent Application Publication Jan. 13, 2011 Sheet 7 of 22 US 2011/00084.57 A1 $####Effffffffffffffffffffffffffffff;$$$$$$$$$$$$$$$$ Patent Application Publication Jan. 13, 2011 Sheet 8 of 22 US 2011/00084.57 A1 ZWEISWC|TOHC/SOHC C]|d|TOHc|HSOHd Eß?ßrffffffffffffffffffffffffff;$$$$$$$$$$$$$$ Patent Application Publication Jan. 13, 2011 Sheet 9 of 22 US 2011/00084.57 A1 --A549 CELLS I -v-H1299 CELLS 2 OO 1OOO CONCENTRATION OFEPA (M) A549CES FIG 9 Patent Application Publication Jan. 13, 2011 Sheet 10 of 22 US 2011/00084.57 A1 14 sis. A549 CELLS 1 2 H1299 CELLS 1 O CONCENTRATION OF EPA (uM) gigs. A549 CELLS H1299 CELLS O 1O 25 50 CONCENTRATION OF EPA (uM) FIG 10 Patent Application Publication Jan. 13, 2011 Sheet 11 of 22 US 2011/00084.57 A1 ESES 49 68 OO 4 O O O 0.1 1 1 TREATMENTS FIG 11 Patent Application Publication Jan. 13, 2011 Sheet 12 of 22 US 2011/00084.57 A1 5. s Patent Application Publication Jan. 13, 2011 Sheet 13 of 22 US 2011/00084.57 A1 s co c c c c C C ed C ex >< d C d C s O en en re- re cd C d SIN? ONS OdVONWIN LL CMO CD Patent Application Publication Jan. 13, 2011 Sheet 14 of 22 US 2011/00084.57 A1 TRANSFECTED siRNAO2M CONTROLS CONTROL S siRNA04M COX-2 - - - - - - - - - - - BACTIN 12O NON-TRANSFECTED 100 TRANSFECTED 8O 60 40 50 CONCENTRATION (M) FIG. 13 Patent Application Publication Jan. 13, 2011 Sheet 15 of 22 US 2011/00084.57 A1 HHONW00Nm'?Nº:10d0ENHETTIOHSHH0SINSINYHOEWETG|Smºld 00700NGVINEdWS00B (°dHHOZ?E)SHOldHOBHENYHENENSNYH?NEAR Patent Application Publication Jan. 13, 2011 Sheet 16 of 22 US 2011/00084.57 A1 25 WHOLE OMEGA ULTIMATE OMEGA CARLSON OIL O 25 1OO 25 1OO 25 OO WHOLE OMEGA ULTMATE OMEGA CARLSON OIL FIG 15 Patent Application Publication Jan. 13, 2011 Sheet 17 of 22 US 2011/00084.57 A1 O 2.25 9 25 1OO 25 OO WHOLE OMEGA ULTMATE OMEGA CARLSONOIL O 25 1OO 25 1OO 25 OO WHOLE OMEGA ULTMATE OMEGA CARLSON OIL FIG 16 Patent Application Publication Jan. 13, 2011 Sheet 18 of 22 US 2011/00084.57 A1 PERCENT GROWTH OFA549 CELLS -e-WHOLEMEGA -O-CARLSONFISHOL -v-ULTIMATE OMEGA O 100 200 300 400 500 FISHOLCONCENTRATION (ug/ml) PERCENT GROWTH OFH1299 CELLS 140 120 100 8O -e- WHOLEMEGA -O- ULTMATE OMEGA 60 -v- CARLSONOIL O OO 2OO 300 400 500 FISHOLCONCENTRATION (ug/ml) FIG. 17 Patent Application Publication Jan. 13, 2011 Sheet 19 of 22 US 2011/00084.57 A1 Patent Application Publication Jan. 13, 2011 Sheet 20 of 22 US 2011/00084.57 A1 N Ø N Ø N =========|9) Ø N OOO Ø WHOLEOMEGA CONCENTRATION (g/ml) FIG. 18B Ø N 250 Ø N 500 Ø N 1OOO Ø CONCENTRATION OF CARLSON SUPERFISHOIL ( g/ml) FIG 18C Patent Application Publication Jan. 13, 2011 Sheet 21 of 22 US 2011/00084.57 A1 GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE A. TUMORNECROSISFACTOR (LIGAND) SUPERFAMILY MEMBER 13B; PHOSPHOLIPASEC, DELTA PHOSPHOLIPASEA2, GROUPIB (PANCREAS) KALLIKREINB, PLASMA (FLETCHERFACTOR)12 INTEGRIN, BETA 1; INTEGRIN, ALPHAL CD40ANTIGEN (TNFRECEPTORSUPERFAMILY); CALCIUMCHANNELBETA 4 SUBUNIT CALCIUM CHANNELLTYPE, ALPHA1DSUBUNIT BRADYKININ RECEPTORB1 BETA-2-MICROGLOBULINE CONTROL ANNEXINA5 EWHOLEMEGA250 ugml ANNEXINA32E ZWHOLEMEGA500 ugm O 5 O 15 20 25 ANDROGENICSURFACEBETA-2RECEPTOR Reesesiggestiger ANNAXNA SEROTONIN RECEPTOR3Assissistagical LEUKOTRENEA-4HYDROLASE MTOGENACTIVATED PROTEINKINASE 8 WASCULARCELLADHESIONMOLECULE1 sigseggi GAPDH D.CONTROL EWHOLEMEGA250 ugm O 5 O 15 20 25 30 %WHOLEMEGA500 ugml ARBITRARY UNIT FIG. 19 Patent Application Publication Jan. 13, 2011 Sheet 22 of 22 US 2011/00084.57 A1 000WMØ +x_1?z.ZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZ) +×||?izzzzZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZ) FIFT [7] FIFTTOEFL FIFT ZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZ F? ZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZ ?zzzZzZzZzZzZzZzZzZzZzZzZzZzZzZzZzZzZzZ ZAZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZ) ZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZ FIFI ?ZZZZZZZZZZZZZZZZZZZZZZZZZZZ. ZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZ FIFI ?)zzº:ZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZ ZZZZZZZZZZZZZZZZZZZZZZZZZZ ?zczaezzzzZzZzZzZzZzZzZzZzZzZzZzZzZzZzZzZzZzZzZ ZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZ) ZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZ ?z-ZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZ |ESWCHSW0 US 2011/0008457 A1 Jan. 13, 2011 COMPOSITIONS AND METHODS FOR which includes prostanoids such as prostaglandins and MODULATING LIPID COMPOSITION thromboxanes, leukotrienes, and hydroxy fatty acids. Eicosanoids are known to affect platelet aggregation, perme CROSS REFERENCE TO RELATED ability and tone of the blood vessel walls, blood pressure, and APPLICATIONS inflammatory immune reactions. 0008. The dietary equilibrium between fatty acids of the 0001. This application claims the benefit of U.S. Provi n-6 and n-3 series is a significant factor in the regulation of the sional Patent Application No. 61/213,334, filed May 29, composition of fatty acids in membranes. In addition, a 2009, and No. 61/272,130, filed Aug. 19, 2009, the contents decreased ratio of n-3 to n-6 dietary fatty acids has been of which are hereby incorporated by reference in their implicated in an increased incidence of health problems, dis entirety. orders, and disease states. The presence of an excess of arachidonic acid (n-6), the precursor of the series 2 BACKGROUND eicosanoids, or an excess of its precursor, linoleic acid (n-6). 0002 1. Field of the Invention may lead to an increase in thrombogenesis, a decrease in 0003. The present subject matter relates to a novel herbal bleeding time, an increase in the inflammatory response of and oil composition and methods for modulating fatty acid polymorphonuclear monocytes and leukocytes, as well as an composition and metabolism in an animal. In one aspect, the increase in Smooth muscle reactivity to allergies. In contrast, Subject matter involves a composition comprising rosemary a diet predominantly based on long chain polyunsaturated extract, oregano extract, and a polyunsaturated oil. In a par fatty acids (PUFAs) of the n-3 series, such as the diet of the ticular embodiment, the polyunsaturated oil is fish oil or a fish-eating populations, produce an Small increase in bleed derivative thereof. In some embodiments, the present subject ing time, and a low incidence of cardiovascular disease. Such matter relates to methods for modulating essential dietary as, atherosclerosis, arthritis, asthma and other diseases. This fatty acid composition of lipoprotein particles or cell mem is due in-part to the fact that these long chain PUFAs of then-3 branes, modulating essential fatty acid metabolism, regulat series are the precursors for the series 3 eicosanoids. ing the activity of lipoxygenases (LOX) and cyclooxygenases 0009. One of the primary goals in consuming fish oils is to (COX), improving cardiovascular health, and/or inhibiting have important constituents found in them become incorpo cell proliferation diseases and disorders. rated into tissue membranes where they serve to modulate cell 0004 2. Background signal events (e.g. reduce inflammation) and increase mem brane fluidity. When cells are activated to release fatty acids 0005 Essential fatty acids (EFAs) are naturally occurring from their membranes through the action of phospholipases unsaturated fatty acids, generally with a chain length of 18, to form eicosanoids, EPA and DHA compete with arachi 20, or 22 carbonatoms.
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