MYOT Cat. No.: 59-047

MYOT Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

This MYOT antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 127-155 amino acids from the Central region of human MYOT.

TESTED APPLICATIONS: WB

APPLICATIONS: For WB starting dilution is: 1:1000

PREDICTED MOLECULAR 55 kDa WEIGHT:

Properties

This antibody is purified through a A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

October 1, 2021 1 https://www.prosci-inc.com/myot-antibody-59-047.html BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: MYOT

Myotilin, 57 kDa cytoskeletal protein, Myofibrillar -like Ig domains protein, Titin ALTERNATE NAMES: immunoglobulin domain protein, MYOT, TTID

ACCESSION NO.: Q9UBF9

PROTEIN GI NO.: 311033402

GENE ID: 9499

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

This encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during . This protein binds F-, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this BACKGROUND: gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

REFERENCES: 1) Bailey, S.D., et al. Diabetes Care (2010) In press :

2) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

3) Shalaby, S., et al. J. Neuropathol. Exp. Neurol. 68(6):701-707(2009)

4) Heikkinen, O., et al. J. Biomol. NMR 44(2):107-112(2009)

ANTIBODIES FOR RESEARCH USE ONLY.

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