MYOT Antibody Cat. No.: 59-047 MYOT Antibody Specifications HOST SPECIES: Rabbit SPECIES REACTIVITY: Human This MYOT antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 127-155 amino acids from the Central region of human MYOT. TESTED APPLICATIONS: WB APPLICATIONS: For WB starting dilution is: 1:1000 PREDICTED MOLECULAR 55 kDa WEIGHT: Properties This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification. CLONALITY: Polyclonal ISOTYPE: Rabbit Ig CONJUGATE: Unconjugated PHYSICAL STATE: Liquid October 1, 2021 1 https://www.prosci-inc.com/myot-antibody-59-047.html BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide. CONCENTRATION: batch dependent Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. Additional Info OFFICIAL SYMBOL: MYOT Myotilin, 57 kDa cytoskeletal protein, Myofibrillar titin-like Ig domains protein, Titin ALTERNATE NAMES: immunoglobulin domain protein, MYOT, TTID ACCESSION NO.: Q9UBF9 PROTEIN GI NO.: 311033402 GENE ID: 9499 USER NOTE: Optimal dilutions for each application to be determined by the researcher. Background and References This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this BACKGROUND: gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. REFERENCES: 1) Bailey, S.D., et al. Diabetes Care (2010) In press : 2) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) 3) Shalaby, S., et al. J. Neuropathol. Exp. Neurol. 68(6):701-707(2009) 4) Heikkinen, O., et al. J. Biomol. NMR 44(2):107-112(2009) ANTIBODIES FOR RESEARCH USE ONLY. For additional information, visit ProSci's Terms & Conditions Page. October 1, 2021 2 https://www.prosci-inc.com/myot-antibody-59-047.html.