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Nancy Davis Foundation for Multiple Sclerosis We are dedicated to the treatment and ultimate cure of MS. Funding research is the core focus of the Foundation and all funds raised support our Center Without Walls program, a selected network of the nation's top MS research centers. This nationwide collaboration of physicians and scientists are on the cutting-edge of innovative research programs, working as a team on therapeutic approaches to eradicate MS. In addition to combating MS through research in a clinical environment, we hope to increase aware- ness by educating the public about this mystifying disease.

Vol. 8 Issue 1 Annual Gala: May 2, 2008

In This Issue Co-Chairs Nancy Davis and Tommy Hilfiger cel- Annual MS Roundtable ebrated the 15th Summary...Page 3 Anniversary Race to Erase MS with a thrilling performance by Shopping Event...Page 3 Frankie Valli & The Four Seasons with spe- Photo Gallery: Erase MS cial celebrity presenters Anne Heche, James Gala...Page 4-5, Page 12-13 Tupper, Tom Arnold, Lisa Rinna and Dr. Phil and Robin McGraw. The event was themed Center Without Walls: Medical "We Heart to Erase MS". The event took Center Summaries...Page 6 place on Friday, May 2nd at the Hyatt Regency Century Plaza and raised over two Pediatric MS...Page 7 million dollars for multiple sclerosis Tommy Hilfiger Celebrity Fashion Show Finale research thanks to a most generous group of Alternative Medicine for supporters. Tommy Hilfiger Corporation, EMD Serono, Associated Television International, MS...Page 7 American Airlines, and the Hyatt Regency Century Plaza all contributed to the tremendous Center Without Walls: funds raised to support MS research. Collaborative Studies...Page 8 The highlight of the evening included an exclusive celebrity fashion show featuring one-of-a- MS Gene Pioneer, Dr. Stephen kind inspired designs by Tommy Hilfiger, modeled by such celebrities as Aly & AJ, Lisa Rinna Hauser...Page 10 and Harry Hamlin, Garcelle Beauvais-Nilon, Keisha Whitaker, Shannon Elizabeth, Maria Menounos, Health Tip and Cheryl Ladd and Tara Reid. The amazing dancers Resources...Page 11 from "Dancing with the Stars" kicked off the evening From our supporters...Page 14 and a spectacular live performance by musical icon Frankie Valli & The Four Seasons who serenaded the Lamborghini Sponsors 2009 crowd with their legendary tunes. The show’s produc- Race Gala...Page 16 tion was graciously donated by Associated Television International.

Tommy Hilfiger, Dee Ocleppo, The ballroom was decked in modern white and vibrant Contact Us Nancy Davis and Ken Rickel orange by well known designer, Mindy Weiss, to com- Nancy Davis Foundation pliment the iconic event theme. The extraordinary flo- for Multiple Sclerosis, ral arrangements were generously donated by Marks The Race to Erase MS Garden. Thank you to our sponsors Makers Mark, Fiji 1801 Ave of the Stars, Water, Barefoot Wine and Bubbly, Asahi, and Frederic Suite 1400 Fekkai and MAC, who created the amazing hair and Los Angeles, CA 90067 makeup for the fashion show.

Phone: 310.440.4842 Tom Arnold and Lisa Rinna raised much needed funds Fax: 310.471.4975 as celebrity auctioneers at the night's exciting live auc- www.erasems.org tion. The high-energy auction featured a spectacular Guest speaker, Teri Garr, with Presenter, Anne Heche (RACE continued on Page 14)

“Yesterday is history, tomorrow a mystery, but today is a gift...that’s why they call it the present.” - Eleanor Roosevelt 18788_Race2erase.qxd:Fall News 2008.qxd 11/26/08 8:14 AM Page 2

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Nancy Davis Foundation Message from Nancy Davis for Multiple Sclerosis President and Founder BOARD OF DIRECTORS

"A diagnosis of any life altering disease is a terrifying Nancy Davis, President experience...the world as you know it is changed in a heartbeat. Tom Arnold Katie Brass When I was told I had multiple sclerosis sixteen years ago, Barbara Davis hopelessness set in as doctors had no substantial information to Dana Davis give me and there were no drugs or therapies available. It is Steve Farber, Esq. Teri Garr remarkable how the MS landscape has significantly changed in Marc Gurvitz the past sixteen years to help stop the progression of this dis- Stephen Hauser, M.D. Tommy Hilfiger ease. Miraculously, there are now six drugs with FDA approval Claudia Curry Hill and a seventh new drug that will hopefully be approved soon. Roy Hilton March Debbie and Jimmy Lustig A cure is so much closer than I could have ever imagined . Hopelessness has been Lynn Palmer replaced by hopefulness. Ken Rickel Montel Williams The amazing doctors that are part of our Center Without Walls program have brought us to the brink of discovering the cause and a cure for this disease. Our THE CENTER WITHOUT WALLS SCIENTIFIC ADVISORY BOARD newsletter is an educational forum to learn about the break-through discoveries these brilliant research scientists have accomplished this past year . I truly believe we must Jack P. Antel, M.D. McGill University, Montreal, Canada, Dept. of continue to push and fight to win this race against multiple sclerosis. With this belief Neurology and Neurosurgery we began our first MS month of May awareness campaign, Orange You Happy to Erase MS, utilizing the vibrant color of orange which we feel symbolizes hope. I am George S. Eisenbarth, M.D., Ph.D. University of Colorado, thrilled at the fabulous response we had this past May and look to all of our support- Health Sciences Center ers who will help make May 2009 even more powerful in raising awareness. Brian Kotzin, M.D. The Center Without Walls commitment as a team to find a cure for MS is an inspi- University of Colorado, ration to all of us, and I am so grateful for their diligent work. The support that the Co-Head of Clinical Immunology CWW receives from our amazing donors and supporters is more than I could have ever Gerald T. Nepom, MD PhD, Director imagined. Thank you to everyone for your generosity and continued commitment to Benaroya Research Institute at Virginia Mason help us realize our dream and find a cure for MS” THE CENTER WITHOUT WALLS RESEARCH CENTERS

Dennis N. Bourdette, M.D. Oregon Health Sciences University

Join our Network at Peter A. Calabresi, M.D. John Griffin, M.D. Johns Hopkins Hospital Go to http://www.uplej.com/erasems and start raising funds for Multiple Sclerosis research! Stephen Hauser, M.D. University of California, San Francisco

uPlej (pronounced "you pledge") is a Professional Fund Raising Richard Rudick, M.D. Organization that combines social networking with charitable giv- The Mellen Center, Cleveland, Ohio ing. For only $4.79 per month everyone can afford to create your Stephen G. Waxman, M.D., Ph.D. own uPlej user page and start giving back to charity! Then spread Yale University School of Medicine the word and tell others to do the same. Howard Weiner, M.D. $1 a month from each friend who joins your uPlej network will go Brigham & Women’s Hospital, Harvard to ERASE MS as well as $1 from their friends and $1 from their Leslie Weiner, M.D. friends' friends. University of Southern California

Together we can raise a significant amount of money for the Nancy Emmanuelle Waubant, M.D., Davis Foundation for MS every month simply by connecting with CWOW Medical Director University of California, San Francisco other charitable individuals, businesses or charities. Join today! 18788_Race2erase.qxd:Fall News 2008.qxd 11/26/08 7:56 AM Page 3

2008 PAGE 3 MS Roundtable Forum Shopping Event May 3, 2008 July 16, 2008 Once a year the Nancy Davis Foundation On July 16, 2008 the for MS invites the general public, MS Nancy Davis patients, families and friends to attend an Foundation for MS Roundtable, an open forum in which Multiple Sclerosis the distinguished doctors from the Center welcomed celebrity Without Walls program share advances in guests and founda- ground breaking research. Attendees have tion supporters to a the unique opportunity to ask questions and cocktail party for the Lyndi Hirsch, Teri Garr, and Nancy Davis to speak to top research scientists. This Melrose Place MS Roundtable is a significant component Louis Van Amstel District Orange Pass to the mission of the Nancy Davis Shops to Erase MS! Shopping Benefit. Foundation, and as always is an important The cocktail party centered on the compliment to the previous evenings gala “Orange You Happy to Erase MS” shop- fundraising event. ping card – the “Orange Pass”, which was available to purchase for $75 with 100% This year, panel members included Dr. Dan of the proceeds going directly towards Greenberg, Dr. Stephen Hauser, Dr. MS research and entitled the bearer to a Richard Rudick, Dr. Emmanuelle Waubant, range of discounts and benefits on fash- Dr. Stephen Waxman, Dr. Howard Weiner ion, beauty and dining in the Melrose Dr. Stephen Waxman and Carmel and Ryan Giese and Dr. Leslie Weiner, as well as distin- Place District during the week of July 17, Claudia Curry Hill with their son guished guests Nancy Davis, Teri Garr, 2008. Participating stores included some Attorney Mark Barondess, and Claudia Curry Hill. The MS Roundtable highlights of the most sought after boutiques in Los important medical research conducted by each of the seven centers, who communicate Angeles, adding excitement and glamour every month to share their findings, and reinforces the need for the existence of The to our “Shop to Erase MS” event. Center Without Walls. "We don't compete, we communicate, share, and cross fertil- Frederic Fekkai, Kate Somerville, Santa ize…. This is unique and the whole is much greater Maria Novella, Carolina Herrera, Diane than the sum of it's parts" said Dr. Stephen Waxman Von Furstenberg, Diesel, Lambertson of Yale University, underlining the importance of the Truex, MAX&Co., Mulberry, Sergio Center Without Walls program. Rossi, Mary Norton, Republic, Comme Ca, Dolce Enoteca e Ristorante, and We would like to thank our sponsors EMD Serono, Kumo donated their time and generosity Hyatt Regency Century Plaza, Le Pain Quotidien and to make this evening event a success. Fiji Water for their invaluable donations towards this very important educational opportunity which is free Participants at the Hyatt Regency and open to the public. If you were unable to attend Century Plaza during MS Roundtable our symposium but would like a copy of the program on DVD, please contact (310) 440-4842.

Heidi Montag “Orange You Happy to and Spencer Pratt Begyi Family with Nancy Davis Erase MS” items to buy!

Panel from top left: Mark Barondess, Claudia Curry Hill, Nancy Davis, Dr. Emmanuelle Waubant, Dr. Ben Greenberg. From bottom left: Dr. Stephen Waxman, Dr. Richard Rudick, Teri Garr, Dr. Howard Dr. Emmanuelle Waubant speaks with Guests shopping at Lambertson Truex Weiner, Dr. Stephen Hauser, Dr. Leslie Weiner participants of the MS Roundtable 18788_Race2erase.qxd:Fall News 2008.qxd 11/26/08 9:06 AM Page 4

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photo gallery: We Heart to Erase MS

Jennifer Lucas Anne Heche, James Tupper, Emmy Rossum, Tommy Cast from “Dancing with the Stars” Nancy Davis and Byron Allen Nancy Davis, and Ken Rickel Hilfiger, and Dee Ocleppo with Frankie Valli

Julianne Hough Katie Brass, Nancy Davis, Sheri Disney, Silvia Baker, Debbie Eaton, Ray and Anna Romano David Horowitz (center) and AJ Brass Markie Post, and Sherry Corday and Guests

Brooke, Jennifer, Debbie, Lynn and Paul Palmer Lisa Rinna Cynthia Haro, Lisa Fitzmaurice, Amy Yasbeck and Jimmy Lustig Diana Meyer, and Cathy Blazej and Guest

Aly and AJ Michalka Kenny Rickel, Nancy Davis, Tommy Laura and David Mckenzie Rick and Paris Hilton, John Duran and Guests Hilfiger, Dee Ocleppo, and Barbara Davis Nancy Davis, Kathy Hilton

Mark Held, Nancy Davis, Arlene and Barry Hirschfeld, Louis Van Amstel and Stephanie and Bill Perkins Victoria Jackson, Nancy Davis, and Richard David Debbie Lustig, and Pam McMahon Kym Johnson and Bill Guthy 18788_Race2erase.qxd:Fall News 2008.qxd 11/25/08 9:02 AM Page 5

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Maria Menounos and Carol Shelby, Darrell Pattillo, Daisy Fuentes Debbie Lustig, Guest, Steve Farber, Barbara Davis, Samantha Harris Nancy Davis Debbie Pattillo, Kevin Shelby and Matt Goss Jan Miller, and Arlene and Barry Hirschfeld

Jerry Sanders with Alex Davis Nicky Hilton, Nancy Davis, Aly and AJ Michalka Katie Brass, Nancy Davis, Jennifer Lucas and Byron Allen and Anne Heche Gelila Puck, and Jennifer Smith Hale

Ileana Douglas Jason and Nancy Davis, Brenda Richie, Evelyn and Brandon Davis Jerry and Tawny Sanders with Guests and Tom Arnold and Tommy Hilfiger Robert Rickel, and Kenny Rickel and Nancy Davis

Nancy Davis, Natasha Croxall, Dana Davis Iris, Michael, and Kailey Smith Terry and Howie Mandel Cammy and Margery St. John and Sahara Pynes and Lynn Palmer Deb MacMillan

Nancy Davis, Tracy Danza, Julie Araskog, Lisa Rinna Claudia Curry Hill Garcelle Beauvais- Andrew Zucker, Lyndi Hirsch, Nancy Arnost, and Lynn Palmer and Harry Hamlin and Cheryl Fisher Nilon and Harriet Sternberg 18788_Race2erase.qxd:Fall News 2008.qxd 11/25/08 9:02 AM Page 6

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highlights from the lab Center Without Walls Program Medical Research Update The Nancy Davis Center Without Walls currently consists of seven of the top MS centers with com- plimentary expertise in multiple sclerosis research. The Nancy Davis Center Without Walls (NDCWW) is highly regarded nationwide as a leading consortium in the development of promising agents for multiple sclerosis (MS). The strategy of the NDCWW is first to evaluate novel treatment approaches in single-center or two-center studies which, if proven promising, are later developed collectively. In addition to trials of candidate agents for MS, the group is developing promising tech- niques to monitor more carefully the disease.

Cleveland Clinic, which the myelin is genetically absent or Harvard Brigham and Director, Richard Rudick, M.D. chemically altered. These are providing information as to how axons that have Women’s Hospital, Director, Howard Weiner, M.D. The Mellen Center has lost their myelin die, e.g. because they found that some immune are transected by immune cell derived communicating molecules enzymes, or because they have lost The team at Harvard is called chemokines are key growth factor support from the myelin. analyzing the linkage of in the brain inflammation The team at Johns Hopkins has found out certain blood and MRI but also in repair process- that this occurs through different com- markers with MS activity es. Identifying which of the munication pathways and hopes to take and response to MS chemokine receptors should be targeted advantage of the protective signals to drugs. The team has also will result in the development of novel devise axon protective therapies. combined MRI measures treatments. The team at the Mellen Center of disease severity for predicting disease has also reported that nerve cells are tran- University of California, progression in patients with MS. In addi- sected not only in MS lesions but also in tion to developing new blood test for the outmost layer of the brain, called cor- San Francisco MS, the team is investigating the role of tex. The team has identified resident Director, Stephen Hauser, M.D. neural stem cells during brain inflamma- immune cells of the brain that play an tion, so deleterious processes can be important role in protecting the brain from The main goal of UCSF identified and inhibited in MS. injury. team is to unravel the genetic makeup that con- Oregon Health Sciences Johns Hopkins vey susceptibility to MS Directors, Peter Calabresi, M.D. and dictate the severity of University and John Griffin, M.D. the disease. Multiple col- Director, Dennis Bourdette, M.D. laborations within the Center Without Walls (OHSU and Johns In the past year, the team Permanent disability in Hopkins) allow for outstanding recruit- at OHSU continued its MS is thought to occur ment of patient samples from various investigation of because of irreversible populations with various risks to develop RTL1000, a novel therapy damage to the nerve MS. The team has observed a higher than for MS developed at "wires" called axons. The expected co-occurrence of other autoim- OHSU. The investigators goals of the team at Johns mune disorders, both in the individual have determined that Hopkins are to define the affected by MS and their relatives. Our RTL1000 shifts the immune system from mechanisms by which new exciting finding that a functional a pro-inflammatory state to a regulated axon injury occurs in MS variant of the interleukine-7 receptor is a state. This bioengineered protein is now and develop imaging bio- risk allele for MS highlights the need for in Phase I clinical trials. The team con- markers of axon and large cohorts and justifies a sense of opti- tinued its groundbreaking research inves- myelin injury. They are mism that the genetic approach will be tigating how modulation of mitochondri- using classical inflamma- increasingly productive with the new al function can protect axons from injury tory animal models of MS as well as generation of tools now available. in a mouse model of MS. Finally, the some novel non-inflammatory models in 18788_Race2erase.qxd:Fall News 2008.qxd 11/25/08 9:02 AM Page 7

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OHSU team continues to be a national leader in the investigation of natural sup- Pediatric Multiple Sclerosis plements, including lipoic acid, omega 3- Emmanuelle Waubant, MD, PhD, UCSF fatty acids, American ginseng extract and ginkgo biloba, as therapies for MS. Although MS typically affects young dren typically do not appreciate that adults with a peak of onset between ages numbness from their waist down or University of Southern 20 and 40 year, up to 10% of patients in decreased vision in one eye is not nor- fact develop their first MS symptoms mal, unless symptoms are severe and California, Los Angeles before the age of 18. This is referred to as interfere with their daily activities and Director, Leslie P. Weiner, M.D. pediatric MS. Children as young as two become detectable by their parents. Thus years old have been diagnosed with MS. mild symptoms may go unnoticed in The team at USC Center is young patients for a while. Also, as the evaluating the role stem Pediatric MS is under recognized by awareness about pediatric MS is low in cells may play in brain pediatricians and child and adult neurol- the medical community, patients may be repair and regeneration. ogists as it is relatively rare (between 10 diagnosed instead with hyperactive dis- The team at USC has stud- and 20,000 cases in the USA) and very orders or viral infections. ied differentiation bio- little has been published on disease pres- markers that control how entation. Therefore, the diagnosis and Although a couple of preliminary studies stem cells will develop into various brain initiation of preventative therapy are suggest that MS is less severe in children cell types that could be used for repair. The often delayed. In fact, families often see than in adults, patients reach similar lev- team also studies brain cell injury utilizing several care providers before the diagno- els of disability at a younger age, thereby micro chambers in which they cultivate sin- sis is established, and are often stressed affecting them during their most produc- gle brain cells exposed to various immune factors or growth factors. Finally the team by how little information is available to tive years of their lives when they are is studying viruses as potential MS triggers. them, as parents. students or young parents. Furthermore, recent data collected in North America Establishing the diagnosis of MS in chil- questions this notion of relative benigni- Yale University dren is harder than in adults. Young chil- ty of pediatric MS. The accumulation of Director, Stephen Waxman, M.D. (PEDIATRIC continued on Page 15)

The goal of the team at Complementary and Alternative the Yale Center is to restore and protect neuro- Medicine for Multiple Sclerosis logical function in animal Dennis Bourdette, MD, OHSU models of MS and trans- late such discoveries Complementary and alternative medi- follows is a brief summary of some of toward effective treat- cine or CAM refers to a broad spectrum this research that has been performed at ments for people with MS. Key objec- of treatments that most conventional Oregon Health & Science University. tives are to investigate the potential of physicians do not prescribe. CAM ther- cell-based approaches in the repair of apies include acupuncture, special diets, We have demonstrated that people with central myelin damage and in the restora- dietary supplements, such as herbs, MS can do yoga safely and it improves tion of nerve impulse conduction in MS; megadose vitamins and fish oil, medita- their fatigue and can be done safely. to preserve neurological function in the tion, energy therapy and many more ther- Yoga thus is beneficial for this MS symp- injured brain and spinal cord via novel apies. Up to three quarters of people tom. strategies that protect axons so that they with MS report taking one or more CAM do not degenerate; to study the molecular therapies and often report deriving bene- Fish oil supplementation The omega-3 makeup associated with poor nerve fit from some CAM treatments. Despite fatty acids (called EPA and DHA) in fish impulse conduction in MS, and identify this, conventional physicians, typically oil have anti-inflammatory effects and strategies that will restore normal con- do not recommend any CAM therapies may also improve depression. We are duction within demyelinated axons. because up until recently there has been currently performing a research study to no scientific evidence to support using assess the effect of fish oil supplementa- any CAM approaches. tion on proinflammatory proteins pro- duced by white blood cells and to deter- Fortunately, research being conducted on mine whether it improves depression CAM through the Nancy Davis Center when used along with anti-depressant Without Walls is beginning to determine medication. Taking a fish oil supplement what works and what does not. What (ALTERNATIVE continued on Page 15) 18788_Race2erase.qxd:Fall News 2008.qxd 11/25/08 9:02 AM Page 8

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Center Without Walls: Group Overview of Clinical Trial Projects COLLABORATIVE on MS activity measure by clinical exam- safety, including MRI monitoring for inations and MRI scans. Enrollment is disease activation and antibody forma- STUDIES complete, and the last patient in the study tion to the RTL1000. This is the first step The Center Without Walls has several is expected to complete the last study in developing RTL1000 as a novel collaborative studies under way in vari- visit at the end of 2008. With this study, immunotherapy for MS. ous stages of development. 6 of the Centers (UCSF, Cleveland, USC, Yale, OHSU and Johns Hopkins) are fol- Studies About to Start Studies Completed In Past Year lowing up on the exciting work in animal models suggesting that Lipitor signifi- CTLA4-Ig Treatment that decreases B cells and anti- cantly decreases the activation of the Harvard is planning a multicenter phase bodies against the nervous system immune system that occurs in MS. Since II trial with CTLA4-Ig (Abatacept) based Several of the seven Centers have been Lipitor may also have neuroprotective on the data reported last year for the involved in a new treatment strategy in properties, the centers use spectroscopy, a phase I trial done at their center. CTLA4- primary progressive (PP) MS using ritux- sophisticated magnetic resonance tech- Ig blocks T cell activation and suppress- imab, a monoclonal antibody against the nique, to determine whether Lipitor pre- es inflammation. The data from the pilot B cell marker CD20 that depletes B cells vents brain damage. This is an exciting study showed that CTLA4-Ig is safe in for over 6 months after the first course of trial, as the medication is given orally and MS, and there is evidence of biologic treatment. B cells are believed to con- is much safer than many immunologic activity by changes in the immune mark- tribute to MS brain inflammation and therapies considered for MS. This is also ers in the blood. make antibodies against constituents of one of the first times the CWW centers the brain. Although this study did not are able to share their advanced magnetic Sodium channel expression within meet its primary endpoint in terms of sta- resonance technology. The study, human MS lesions tistical significance, there was a modest designed by UCSF, is also sponsored by Yale and Cleveland are examining the reduction in disease progression in PPMS the Immune Tolerance Network, Biogen slow burn of axons in chronic lesions patients who received rituximab com- Idec and Pfizer. which have been implicated to play a pared to those who received placebo, par- major role in MS disability. The group ticularly if they had experienced progres- Memantine - MS cognitive impairment was ready to follow-up with a clinical sion before enrolling in the trial. This year OHSU, in collaboration with trial of an oral sodium channel blocker in Rituximab recipients also had a lesser USC, has conducted a double blind, patients with MS, but this study is on brain MRI progression over the 2-year placebo-controlled pilot trial of meman- hold because of preliminary data in the period of the study. Rituximab is admin- tine for cognitive impairment in MS. animal model suggesting that a rebound istered intravenously every six months. It Memantine is a glutamate receptor antag- may occur when discontinuing the drug. is FDA-approved for non-Hodgkin lym- onist that has been shown to improve Additional data in animals are being phoma and rheumatoid arthritis and is cognition in Alzheimer's disease. This acquired before starting the study in MS. well tolerated except for mild to moder- trial is designed to assess whether ate infusion-related reactions. Further memantine will improve cognition A study targeting macrophages studies will confirm whether some among MS patients. One hundred A multicenter phase I study involving patients with progressive MS can benefit patients have completed the study. Data UCSF, USC, Cleveland Clinic and from this therapeutic strategy. should be analyzed by the the end of OHSU will start at the end of 2008 to 2008. evaluate the safety and preliminary effi- Ongoing Studies cacy of a monoclonal antibody targeting Recombinant T Cell Ligand Therapy macrophages in patients with relapsing- The NDCWW has continued or initiated Two of the Centers, OHSU and Yale, remitting and secondary progressive MS. patient enrollment in several collabora- have initiated a Phase I safety and dose This study is sponsored by Amgen. tive clinical trials of medications for MS finding study of the DR2-MOG 35-55 that have been designed by the NDCWW. RTL, referred to as RTL1000. Patients with MS and positive for a specific mark- SINGLE-SITE PILOT Lipitor (atorvastin) for early MS er (DR2+) will receive single intravenous STUDIES Eighty-three patients with their very first infusions of RTL1000 of increasing Some very novel agents are currently MS event have been enrolled nationwide doses (6-300 mg). The study should be being developed by individual NDCWW in this study that evaluates the effect of completed next year. Outcomes will be centers. Single-site studies serve the Lipitor compared to placebo for one year 18788_Race2erase.qxd:Fall News 2008.qxd 11/25/08 12:47 PM Page 9

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valuable function of deriving prelimi- patients participated. One of the formula- ginseng for treatment of MS fatigue. nary data that, if encouraging, will come tions gave the highest plasma levels of Results are expected in the fall 2008. to fruition as larger collaborative trials lipoic acid. This will lead to a study com- Forty-two patients participated to this bining lipoic acid and interferon in trial. Studies Completed In Past Year patients with secondary progressive MS. Functional imaging of episodic memory Oral anti-CD3 High dose cyclophosphamide study dysfunction in MS Murine OKT3 monoclonal antibody is an Nine patients have been treated at Johns The group at the Cleveland Clinic is approved therapy for the treatment of Hopkins with immunoablative doses of developing a novel strategy of imaging to transplant rejection and humanized anti- IV cyclophosphamide in patients with improve our understanding of memory CD3 monoclonal antibody has shown RRMS refractive to other therapies. This dysfunction in MS. positive clinical effects in new onset dia- aggressive treatment approach seems betes in humans. Based on animal stud- promising for very active MS. A confir- Optical Coherence Tomography ies, the group at Harvard has tested the matory study is in planning. Several of the groups, including effect of oral administration of murine Cleveland Clinic, Johns Hopkins, UCSF OKT3 in 18 healthy human subjects for 5 Daclizumab and USC are investigating whether a new days. Immune effects were observed in This monoclonal antibody blocks T cell painless technique called optical coher- all subjects with the most consistent activation and induces a unique type of ence tomography that measures the nerve responses observed at the 1.0 mg dose. regulatory cell. The group at Harvard has fiber layer in the back of the eyes is cor- No side effects were observed. These completed an open-label study of 59 related to several MRI measures and findings demonstrate that oral anti-CD3 patients which shows that a majority of whether it reflects well nerve tissue dam- monoclonal antibody is biologically patients benefited age. active in humans and is applicable for the treatment of human autoimmune dis- Ongoing Studies eases such as MS. A follow-up study is in Studies About to Start the planning for next year to evaluate Neuroprotection/ riluzole in early MS various dosages. UCSF has initiated one of the first studies Alpha Lipoic acid with a neuroprotective drug, riluzole, in OHSU will test oral alpha lipoic acid in CTLA4-Ig patients with early MS. Riluzole is an the coming year as an adjuvant therapy to The modulation of co-stimulatory path- approved drug already shown to slow interferon beta for patients with second- ways represents an original therapeutic down Lou Gehrig's disease. Patients ary progressive MS. The study protocol is approach to regulate T-cell mediated receive two years of therapy with riluzole being finalized. autoimmune diseases by preventing or or placebo in addition to interferon beta- reducing auto-antigen driven T cell acti- 1a as a standard of care. Twenty-one Ginkgo Biloba for cognitive impairment vation in humans. The group at Harvard patients have been enrolled in the study in MS has used CTLA4-Ig intravenous since January, 2007. A total of 40 patients OHSU is about to start a study in 100 infusions to block the CD28/B7 T cell will participate ino this study at UCSF. patients that will test Ginkgo compared to co-stimulatory pathway in a phase I, Sanofi-Aventis is providing free riluzole placebo for three months as a treatment of dose escalation study in MS. Sixteen and placebo, and Biogen Idec is provid- cognitive problems related to MS. patients with relapsing-remitting MS ing free interferon beta-1a. It is likely that received a single CTLA4-Ig infusion and OHSU will collaborate in this project if Anti-CD3 therapy 4 additional subjects received 4 doses of enrollment is slow at UCSF. Harvard is planning a phase I trial with CTLA4-Ig. Inhibiting co-stimulatory oral anti-CD3 monoclonal antibody that molecule interactions by using CTLA4- Omega-3 fatty acid in treatment of suppresses the animal model for MS. This Ig appears safe in MS and the immuno- depression & as an immunomodulator study will evaluate several doses of the logic effects suggest that it may be a OHSU is continuing with the study of medication and will determine if the ther- promising approach to regulate the omega-3 fatty acid in the treatment of apy induces regulatory cells in the blood. inflammatory processes associated with depression in patients with MS and is also MS. The center at Harvard is following evaluating how this compound modulates Vitamin D replacement up with the design of a larger scale study the immune system in a way that could The group at Johns Hopkins is planning to confirm their findings. benefit to MS. Forty-two patients have to start the evaluation of immunological been enrolled. benefits of high dose vitamin D replace- Alpha lipoic acid ment in MS. The group at OHSU has completed a American ginseng for MS fatigue study of three different formulations of OHSU is currently analyzing the results oral alpha lipoic acid in which 40 of the study performed with American 18788_Race2erase.qxd:Fall News 2008.qxd 11/25/08 12:47 PM Page 10

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On the Cusp of a New world: MS Gene Pioneer Center Without Walls Dr. Stephen Hauser Shares his Vision Collaborating Physicians Excerpts By Sara Bernstein Dr. Jack Antel, Montreal Neurological Hospital "This is a time of great momentum," said Stephen L. Hauser, MD. "We are at the cusp Dr. Rob Bakshi of understanding the genetic basis of MS with a resolution that we could never have Brigham & Women's Hospital imagined just two or three years ago." Dr. Hauser would know; he has received the Dr. Guy Buckle, Harvard Brigham & Women's Hospital National MS Society/American Academy of Neurology's 2008 John Dystel Prize for Dr. Michael Carrithers, MS Research in recognition of two decades of pioneering studies on genetic suscepti- Yale University bility to MS. Dr. Tanuia Chitnis, Harvard Brigham & Women’s Hospital Dr. Jeffrey Cohen, Dr. Hauser's excitement about MS genetics is due to the work of the International Cleveland Clinic Multiple Sclerosis Genetics Consortium (IMSGC), a group of international MS genet- Dr. Kathy Conant, ic experts created with funding from the Society…. Not only will we have a 'dic- Johns Hopkins tionary' of the genes that are important in MS, but much more significant, this infor- Dr. George Eisenbarth, University of Colorado, mation is likely to transform our understanding of just how MS begins." Although Dr. Health Sciences Center Hauser surmises that there are probably 50 or so susceptibility genes for MS, he Dr. Elizabeth Fisher, believes that identifying these genes will not complicate the MS picture, but will lead Cleveland Clinic us to a much simpler view of disease pathways, better treatments, and prevention. Dr. Bob Fox, Cleveland Clinic Dr. Suzanne Gauthier, Harvard Dr. Hauser hopes to follow up this genetics effort with a study of people who can be Brigham & Women’s Hospital identified as being at increased genetic risk for MS. Investigators would seek to iden- Dr. Wendy Gilmore, tify a series of changes in the immune system that occur before the damage to nerve- University of Southern California Dr. Ari Green, fiber insulating myelin-the hallmark of MS-begins. "Armed with new genetic knowl- University of California, San Francisco edge and insight from immunology, we should be able to identify people at risk for Dr. Charles Guttman, Harvard MS and understand the very first steps," said Dr. Hauser. "Wouldn't it be wonderful Brigham & Women’s Hospital to prevent MS before it begins?" Dr. Halina Hoffner, Oregon Health Sciences Dr. Norman Kachuck, Long interested in the immune activity that underlies MS, Dr. Hauser published sem- University of Southern California inal findings associating antibodies (proteins produced by B cells) with damage to the Dr. Samia Khoury, Harvard myelin. (Nature Medicine 1999 Feb;5[2]; 170-5) These lab findings resulted in a clin- Brigham & Women’s Hospital Dr. Jeff Kocsis, ical trial of rituximab (Rituxan, from Genentech and Biogen Idec), a drug that depletes Yale University B cells. Dr. Brian Kotzin, Amgen "The development of rituximab has been thrilling," said Dr. Hauser. "We found that Dr. Brett Lund, University of Southern California treatment was effective against relapsing-remitting MS beyond what we had imag- Dr. Gerald Nepom, ined." Dr. Hauser and colleagues reported that one course of this intravenous drug Virgina Mason, Seattle reduced disease activity -for 48 weeks in people with relapsing-remitting MS, a course Dr. Jorge Oksenberg, of MS Characterized by clearly defined flare-ups followed by partial or complete University of California, San Francisco Dr. Daniel Pelletier, recovery periods. (The New England Journal of Medicine 2008 Feb 14;358[7]; 676- University of California, San Francisco 88). Dr. Jana Preiningerova, Yale University Dr. Hauser looks forward to a bright future in MS research, where novel collaborations Dr. Richard Ransohoff, Cleveland Clinic and therapeutic strategies are bringing us closer to a world free of the disease. "These Dr. Daniel Reich, exciting new developments could change the face of what is possible for people with Johns Hopkins MS," he concluded. Dr. William Rooney, Oregon Health Sciences Momentum Dr. Bruce Trapp, Resource: , Fall 2008 Cleveland Clinic Dr. Arthur Vandenbark, The Nancy Davis Foundation for MS is proud to support the research of Dr. Oregon Health Sciences Stephen Hauser at UCSF and we congratulate him on the prestigious award of the Dr. Arun Venkatesan, Johns Hopkins National MS Society/American Academy of Neurology's 2008 John Dystel Prize for Dr. Ruth Whitham, MS Research. Oregon Health Sciences Dr. Scott Zamvil, Thank you Dr. Stephen Hauser for your passion to find a cure for mulitple sclerosis! University of California, San Francisco 18788_Race2erase.qxd:Fall News 2008.qxd 11/25/08 12:47 PM Page 11

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ms health tips and resources 300 Tips for Making Life Fear, Anger, Depression Two Steps Forward Easier, 2nd Edition Forbes, September 1, 2008 Dealing with fear, anger, and depression Shelley Peterman Schwarz can be the result of the effect of MS on Robin Giese, 59, Kicks off each day by the brain. But these are also natural emo- This completely revised second edition getting out of her wheelchair for a half- tions that come from dealing with the of Multiple Sclerosis: 300 Tips for hour ride on a stationary bike followed unfairness of losing what we may have Making Life Easier contains tips, tech- by 30 minutes of stretching exercis- thought of before as a “normal life.” niques, and shortcuts to help MS patients es….Giese hasn't always been so active. While such feelings may be inevitable, organize and simplify their lives. From She has multiple sclerosis...Over three their persistence can be harmful. Be as basic principles to unique solutions for decades multiple sclerosis has slowly honest with yourself as you can. This saving time and energy to specific ideas, robbed Giese of her mobility and weak- means not denying reality or creating this book is packed with helpful infor- ened her muscles, and without treatment false expectations. Develop a positive mation for those coping with the special she would be all but immobilized in her attitude by thinking about things that can challenges of a chronic illness. Updated wheelchair. But an experimental drug be done instead of things that cannot be chapters cover Home Safety and has changed the course of her disease- undone. Do volunteer work, help a friend Accessibility, Computers and and her husband's career path. or relative in time of need. All of these Technology, Looking Good, Feeling things can have a therapeutic effect. Better - Grooming and Dressing, The compound, called dirucotide, is a Hope and acceptance come when you Managing Mealtime, and much more. chain of 17 amino acids that mimics a realize that MS is now another part of NEW sections include: Managing med- portion of the protein in myelin. It works you and doesn’t define you – and that life ical issues Travel tips for weekend get- by acting as a decoy to divert the attack- is about today and less about yesterday aways or extended travel Unique product ing immune cells. It has had such a pro- or tomorrow. suggestions for practical helpful items found impact on Robin's condition that that make everyday tasks easier her husband has started a company, http://www.mswatch.ca/community/section.aspx?SectionI BioMS Medical, to bring it to market. Resource section to easily locate prod- d=689b4448-a836-4a8d-97db-0bd0d6d2b980 ucts and services Today dirucotide is one of two novel MS MS: Eating Right Multiple Sclerosis: 300 Tips for Making drugs in late-stage clinical trials. Most Life Easier, 2nd Edition is a valuable existing MS therapies work by suppress- Healthy eating is important for everyone, resource for individuals living with MS, ing the immune system, and they're gen- but it is particularly important if you family members, caregivers, and medical erally effective only when the disease is have a chronic illness, such as multiple professionals. at an early stage. sclerosis. What Are Some Basic

http://www.demosmedpub.com/prod.aspx?prod_id=9781 Nutrition Guidelines for People With Dirucotide began with research conduct- 932603217 MS? 1) Eat a variety of foods from each ed at the University of Alberta by doctors food group; maintain your weight Kenneth Warren and Ingrid Catz. In through a proper balance of exercise and 1989 Warren developed a synthetic pep- Fish Oil and MS food. 2) Choose foods low in saturated tide that mimics myelin protein. fat and cholesterol, unless otherwise According to researchers from Oregon directed by your healthcare provider. 3) The results so far have been very prom- Health & Science University, fish oil has Try to limit how much sugar you eat and ising. Patients with either of two genes been shown to ease the symptoms of MS. moderate your use of salt. 4) If you associated with autoimmune disorders, Patients with multiple sclerosis who choose to drink alcoholic beverages, do HLA-DR2 and HLA-DR4, have gone were given fish oil found that their symp- not consume more than one or two bev- five years without any progression of the toms improved significantly and the lev- erages per day. 5) Drink eight 8-ounce disease. Those genes are found in 65% els of inflammatory proteins in their glasses of water per day and limit caf- to 75% of all MS patients, and because of blood was down nearly 60 percent. “The feine consumption. that analysts estimate that the potential findings confirm previous research find- market for drugs like dirucotide, effec- ings that suggest the intake of fish oil Reviewed by the doctors at the Mellen tive for patients at later stages of the dis- containing omega -3 fatty acids could Center for Multiple Sclerosis Research at ease, could reach $10 billion a year. The provide a measure of relief for those with The Cleveland Clinic. current market for all existing MS drugs MS,” the investigators conclude. is $6 billion. Resource: www.webmd.com/multiple- sclerosis/guide/multiple-sclerosis-eating-right Resource: NE September 17, 2007 Forbes, September 1, 2008. 18788_Race2erase.qxd:Fall News 2008.qxd 11/25/08 12:48 PM Page 12

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photo gallery, continued We Heart to Erase MS

Michael Fredo with Michael Smith, Beny Alagem, Aly and AJ Michalka with Guests Marcy Taub Eric Benet with Guest and Kim and Andy Hilfiger and Kenny Rickel and Lynn Palmer Michael and Iris Smith

Katie Brass and Nancy Davis, Shannon Elizabeth Emma Sharratt and Guests Dean Singleton with Guests Elaine Tack, Shannon Cassidy and Friends and Nancy Davis

Jan Miller, Gary Gilbar, Anne Heche Alagem Family Sherry Corday David and Beth Jillian Barberie and and Pepita Serrano and Nancy Davis and Robin Correll Horowitz Grant Reynolds

John and Jordan Davis, Robin Broidy Deb MacMillian Family and Guests Emmy Rossum Steven and Julie Araskog and Nancy Davis and Nancy Davis and Jennifer Pal

Jack Rich and Ali Landry Dr. Stephen Hauser, Dr. Elizabeth Robins, Tara Reid Mary Virginia Knight Cheryl Ladd Elaine Hauser, Nancy Davis and Henry Fong 18788_Race2erase.qxd:Fall News 2008.qxd 11/25/08 12:49 PM Page 13

2008 PAGE 13

Jeremy & Caroline Finkelstein, Stephanie & Kelly Hu Julianne Hough, Nancy Davis, Angelica Castro, Cristian de la Fuente, Marky Ramone Ernie Cockrell, and JoAnna Barrett with Guest and Maria Menounos and Derek Hough Nancy Davis, and Chuck Binder

Guests with Nancy Davis and Yaara Elisha Judith and Dr. Leslie Weiner, Josie Bissett Adele and Beny Karen and Dr. Gary Richman Penny Marshall and Will MacMillan, Jr. Guest with Luci Lawrence Alagem

Keisha Whitaker Mary Conner (center) with Guests Kristi Yamaguchi and Dana Davis, Tony Williams, Rose, Mark, and Andrew Barondess Mark Ballas and Barbara Robinson with Lynn Palmer

Nick Chavez and GuestWendi and Dan Goldman with Leeza Gibbons Sue and Paul Sharratt with Guests Ceron with Nancy Davis and Andy Gelb Alexandra and Brady Knight

Uyen and Brad O’Leary Marlee Matlin (center) and Guests Claude and Alfred Mann Roxane Begyi Avi Cohen, Tova Celine and Nancy Davis and Susan Neisloss 18788_Race2erase.qxd:Fall News 2008.qxd 11/25/08 12:49 PM Page 14

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from our supporters School Essay Contest Winner! The MonSter Ana Randall entered an essay contest in her 7th grade class at A poem by Michele Chambers Marshall Middle School in which a $50 check would be sent to the charity or cause that was written about in their essay. Ana won! The You sometimes see the way I walk check was gratefully recieved by the Nancy Davis Foundation for You sometimes tell the way I talk MS. Thank you Ana for writing sucha wonderful essay in support But you look fine I always hear of your father and the foundation.Enjoy Ana’s winning essay: Then I say those words you fear Ana Randall It conjures visions many dread “Imagine finding out that someone you love or know can become blind or paralyzed The MonSter’s reared its ugly head any day of their life. I know that feeling because my dad has multiple sclerosis. Some diagnosed in time to fight Multiple sclerosis, or MS, is the erosion of your meniscus, or the spinal coating that Yet those like me too late just fright protects your nerves. The erosion is caused by your body thinking that your meniscus You sit with hope, fear and terror is dangerous, therefore it attacks it, causing the lesions. If treatment is not given That maybe it was done in error though MS can cause numbness, heat intolerance, blindness, and in the long run death. Those two slight letters evoke distress That is why I would like to give our money to the Nancy Davis Foundation for That inescapable phrase, “you have MS” MS. The Nancy Davis Foundation helps find a cure, while it empowers families to I cannot work, I cannot run have hope. You’ll hardly find me in the sun Imagine having to pay for the weekly shot, while living in a low income family, Those years the Doctor didn’t see it would really takes it toll. That is why I would like to give our money to the Nancy The MonSter had control of me Davis Foundation, so that we could help everyone with MS. The tingling comes in dead of night So that is why I would like to have our money be given to the Nancy Davis You try to rest with all your might Foundation. So no other child or parent will have to know the pain of loosing a loved The pain you feel you can’t express one. Thank You.” Being tortured though you can’t confess With its own rules this MonSter goes (PEDIATRIC continued from Page 7) (RACE continued from Page 1) And mercy’s not a word it knows disability in pediatric cases in North list of luxury items including a Harley You want to scream and beg why me America seems more rapid than previous- Davidson designed by Tommy Hilfiger But MonSter does not care you see ly described, challenging the benign and an Ultimate Parisian fashion experi- So I smile, and say I’m fine nature of the disease. It is unclear ence which included first class airfare on This misery must be just mine whether this is in part explained by a dif- American Airlines. Those strangers, their disgusted leers ferent ethic background in children: half Will almost always bring the tears of the pediatric MS patients in North Among the guests were such superstars as I’ve learned to rant and cry inside America are not white, compared with Howie Mandel, Ray Romano, Anne The healthy rules I must abide 20% of adult MS patients. Heche, Emmy Rossum, Paris and Nicky An injection I now take each day Hilton, Shannon Elizabeth, Maria The pain on pain a price I pay Finally, it is also possible that there is an Menounos and James Tupper. To keep the MonSter slight at bay increased risk to develop MS in children No more attacks each night I pray who are coming from ethnic groups in Thank you again to everyone involved in Though each new day as I awake which typically the disease is rare. It helping to make this evening such a grand Each leg I shake, a chance I take remains to be determined whether this is success. Please make sure to save the One eye I have, I beg I’ll see related to environmental factors or genet- date of May 8, 2009 for our 16th Annual The MonSter did not visit me ic background or both.For a long time Race to Erase MS at the Hyatt Regency My battles lost, but not the war physicians did not feel comfortable treat- Century Plaza! I’m hoping many years to for ing children with MS with drugs Though I may slur and sometimes fall approved for adult MS as no data were I won’t give in to MonSters call available regarding safety of these drugs. There is now reasonable information gathered over the past 10 years on the tol- Thank you to Michelle for sharing her erability of interferon and Copaxone. poem with us and we appreciate her This has resulted in the larger use of these email and support of the Nancy Davis agents in children who develop an active Foundation for Multiple Sclerosis! form of MS. Whether these agents are as beneficial in children as in adults remains to be found. 18788_Race2erase.qxd:Fall News 2008.qxd 11/25/08 12:49 PM Page 15

2008 PAGE 15

“ORANGE YOU HAPPY TO ERASE MS” Month of May MS Awareness Campaign

Together we can heighten awareness for multiple sclerosis and bring hope to those affected by this disease.

With the support of fabulous retailers we will have a spectacular collection of items in the signature MS orange - the vibrant color of hope - for purchase in support of educating the community and funding MS research.

Visit us at www.erasems.org during the month of May and propel us one step closer to finding a cure for multiple sclerosis. For more information on how to help contact us at 310-440-4842 or [email protected].

(ALTERNATIVE cont. from Page 7) TRIBUTE CARD PROGRAM that provides 1-2 gm/day of EPA and 0.5- Protect Yourself 1 gm/day of DHA is safe and may be beneficial. Pay tribute to friends and and Your Family family for special occasions Ginkgo biloba for memory problems We and help us win the RACE to Every year 98,000 people in the United have completed a small double blind Erase MS! States die from preventable medical mis- placebo controlled trial of ginkgo biloba takes and 400,000 people are injured by (120 mg twice a day) for memory prob- these mistakes making this the sixth lead- lems in MS. This study suggested that We will send a card with your ing cause of death in our country. ginkgo biloba was safe and beneficial. personal message to your We have started a much larger placebo friends and family on your My Very Necessary Medical I.D. Card™ controlled trial involving 100 volunteers behalf. fits easily in your wallet and contains with MS to prove that it is helpful. your most essential medical information in case of an emergency when you can't Lipoic acid Lipoic acid is an orally speak for yourself. Our service allows active anti-oxidant that is effective in you to store and retrieve your medical treating mice with an experimental, MS- and legal records and will assist in reduc- like disease. We have shown that taking ing healthcare inefficiencies, limit the lipoic acid (1200 mg once a day) pro- possibility of medical errors, and ensure duces therapeutic blood levels of the one's legal wishes. We have developed a anti-oxidant and lowers proteins associ- safe and secure method to organize, store, and immediately access one's important ated with MS disease activity. Actual Card medical information and legal wishes American ginseng extract We recently It is a thoughtful gesture for a from anywhere in the world by using the internet or calling one of our customer completed a placebo controlled trial of Birthday, Anniversary, Thank American ginseng extract to determine service associates 24/7. My Very whether it is effective in improving You, Speedy Recovery or any Necessary Medical I.D. Card™ has part- fatigue in MS. The results of this trial occasion. nered with AccessMyRecords.comSM to will be available this coming fall. offer you this valuable service. See the self mailer included www.vnmedical-idcard.com Research on CAM is important because in this newsletter, go online it will demonstrate what works and what 800-796-6431 does not. Support provided to scientists www.earsems.org, or gifts through the Nancy Davis Center Without can be made by calling our Walls is helping to advance this impor- office at (310) 440-4842. tant research. 18788_Race2erase.qxd:Fall News 2008.qxd 11/25/08 12:49 PM Page 16

2008 PAGE 16 Lamborghini 16th Race to Erase MS Gala 2009 Exculsive Auto Sponsor Friday, May 8, 2009 We are pleased to announce Automobili Lamborghini S.p.A. as Hyatt Regency Century Plaza our exclusive automo- For more information please call 310-440-4842 or bile sponsor of the 2009 visit www.erasems.org Race to Erase MS event. Lamborghini will be donating one of 2009 MS Roundtable its newest super sports cars as well as a personal tour of its birthplace; Saturday, May 9th the historic Lamborghini factory in Sant’Agata Bolognese, Italy to our Live Hyatt Regency Century Plaza Auction. Working together, Lamborghini and the Nancy Davis Foundation for MS will part- Free to the public. Open forum with our top MS ner to raise record funds to fight this debilitat- research scientists speaking on the latest advance- ing illness. ments in multiple sclerosis research.

Lamborghini’s DNA is characterized by its origin. No other region in the world is as Major Sponsors intensely formed by the passion for the fine sound of high-performance engines as the Thank you for your generous support! region of Emilia Romagna in northern of Italy. The design of a Lamborghini is always unique. Even when presented for the first time, every new Lamborghini is intrinsically destined to become a future legend and a sought-after classic.

The Lamborghini will be featured in the Live ASSOCIATED TELEVISION INTERNATIONAL Auction on May 8, 2009 at the Hyatt Regency Century Plaza during the Race to Erase MS event. For information on tickets and sponsor- ships, please call the Nancy Davis Foundation at (310) 440-4842 or email [email protected].

Nancy Davis Foundation for Multiple Sclerosis Non-Profit Org. 1801 Avenue of the Stars, Suite 1400 U.S. Postage Los Angeles, CA 90067 PAID Phone: 310-440-4842 GWS. CO Fax: 310-471-4975 Permit No. 5605 http://www.erasems.org

Address correction requested

Nancy Davis Foundation for Multiple Sclerosis is a tax exempt 501(c)(3) charitable organization. We do not endorse any company, product or organization referenced in this publication.