Wo 2010/096542 A2
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(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 26 August 2010 (26.08.2010) WO 2010/096542 A2 (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, A23G 3/36 (2006.01) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, PCT/US2010/024565 KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (22) International Filing Date: ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, 18 February 2010 (18.02.2010) NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (25) Filing Language: English TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 61/153,459 18 February 2009 (18.02.2009) US GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, (71) Applicant (for all designated States except US): CAD- TM), European (AT, BE, BG, CH, CY, CZ, DE, DK, EE, BURY ADAMS USA LLC [US/US]; 389 Interpace ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Parkway, Parsippany, New Jersey 07054-1 192 (US). MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (72) Inventors; and ML, MR, NE, SN, TD, TG). (75) Inventors/Applicants (for US only): FERRI, Dino C. [US/US]; 2 Roosevelt Avenue, Lake Hiawatha, New Jer Declarations under Rule 4.17: sey 07034 (US). MICHAELIDOU, Tasoula A. — as to applicant's entitlement to apply for and be granted [US/US]; 19 Elm Street, Bergenfield, New Jersey 07621 a patent (Rule 4.1 7(U)) (US). STOJANOVIC, Jelena [RS/US]; 44 Center Grove Road, Apt N50, Randolph, New Jersey 07869 (US). — as to the applicant's entitlement to claim the priority of WATSON, Deborah L. [US/US]; 2A Dickens Place, the earlier application (Rule 4.1 7(Hi)) Haskell, New Jersey 07420 (US). Published: (74) Agent: KONKOL, Chris P.; Cantor Colburn LLP, 20 — without international search report and to be republished Church Street, 22nd Floor, Hartford, Connecticut 06103 upon receipt of that report (Rule 48.2(g)) (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (54) Title: CONFECTIONERIES PROVIDING MOUTH-MOISTENING REFRESHMENT (57) Abstract: The present invention relates to confectioneries that impart a mouth-moistening effect when orally consumed by an individual. Specifically, the confectioneries comprise compositions that include a blend of components comprising spilanthol to reduce or eliminate the perception of mouth dryness in an individual. The confectioneries can further include such components as a sweetening composition, a food-grade acid composition, and a cooling agent composition. CONFECTIONERIES PROVIDING MOUTH-MOISTENING REFRESHMENT BACKGROUND OF THE INVENTION [0001] This disclosure relates to compositions and confectioneries that impart a mouth-moistening effect when orally consumed by an individual. [0002] Consumers sometimes desire confectioneries that can provide a refreshing and mouth-watering effect. Some individuals can experience dryness in the mouth from time to time due to a variety of physiological and environmental factors. A dry mouth can be caused by a dry or low humidity environment. A dry mouth can also be caused by reduced levels of saliva and can make an individual's mouth feel sticky and uncomfortable. Some individuals can even suffer from what is referred to as "xerostomia," a chronic condition of abnormal dryness in the mouth. [0003] A dry mouth can lead to difficulties in tasting, chewing, swallowing, and speaking, as well as to a variety of more serious medical conditions. Prescription medications and artificial saliva are available for severe cases of dry mouth. Individuals experiencing low or moderate levels of mouth dryness, however, often desire consumables that provide a sensation of hydration or mouth moistening. Although water is often sought for relief of mouth dryness, it is not always convenient or portable, and it does not always provide long-lasting relief. [0004] There is a need, therefore, for confectioneries that can provide a sensation of mouth moistening upon consumption. Confectioneries are portable and so can be consumed whenever a feeling of dry mouth is experienced by an individual. Further, mouth moistening in combination with sweetness, flavoring, and refreshing sensations can be an enjoyable experience for the consumer, even in the absence of optional additional functions such as breath or medicinal treatments that can also be contained in a confectionery. [0005] To contribute to a refreshing oral experience, a confectionery product can also contain moderate to high levels of one or more cooling agents. Many substances are known to provide a sensation of cooling on application and are called "cooling agents." Examples of cooling agents that are trigeminal stimulants include menthol; WS-3; N-substituted p- menthane carboxamido; acyclic carboxamides including WS-23, WS-5, WS-14; methyl succinate; and menthone glycerol ketals. Other cooling compounds can include derivatives of 2,3-dimethyl-2-isopropylbutyric acid such as those disclosed in U.S. Patent No. 7,030,273, which is incorporated herein by reference. Other examples include isopulegol, 3-(l- menthoxy)propane-l,2-diol, 3-(l-menthoxy)-2-methylpropane-l,2-diol, p-menthane-2,3-diol, p-menthane-3,8-diol, 6-isopropyl-9-methyl-l,4-dioxaspiro[4,5]decane-2-methanol, menthyl succinate and its alkaline earth metal salts, trimethylcyclohexanol, N-ethyl-2-isopropyl-5- methylcyclohexanecarboxamide, Japanese mint oil, peppermint oil, menthone, menthone glycerol ketal, menthyl lactate, 3-(l-menthoxy)ethan-l-ol, 3-(l-menthoxy)propan-l-ol, 3-(l- menthoxy)butan-l-ol, 1-menthylacetic acid N-ethylamide, l-menthyl-4-hydroxypentanoate, 1- menthyl-3-hydroxybutyrate, N,2,3-trimethyl-2-(l-methylethyl)-butanamide, n-ethyl-t-2-c-6 nonadienamide, N,N-dimethyl menthyl succinamide, and menthyl pyrrolidone carboxylate. [0006] Menthol is well known for its physiological cooling effect on the skin and mucous membranes of the mouth. The "cooling" effect of menthol appears to be a physiological effect arising from the direct action of menthol on the nerve endings responsible for the detection of hot and cold. Menthol directly stimulates cold receptors. In addition to its "cooling" effect, menthol also imparts other physiological effects such as "nasal action," "aroma," and "minty taste." Since, however, there are disadvantages associated with using menthol, including its strong minty odor and the harsh notes it imparts to some compositions, efforts have been directed to replacing, reducing, or supplementing menthol with other compounds to provide substantially the same physiological cooling effects but without the disadvantages of menthol alone. For example, some non-menthol compounds providing a physiological effect similar to menthol are described in U.S. Patent No. 4,296,255 of Rowsell et al. Other compounds exhibiting a physiological cooling effect are described in U.S. Patent No. 7,030,273 B l to Sun. Other efforts have also been directed to the development of combinations of cooling agents and other components that can provide a different release profile in confectioneries, for example, which can provide more long-lasting properties. U.S. Patent Application Publication No. US 2005/0019445 A l of Wolf et al. describes a combination of physiological cooling agents to provide a reduced overall concentration of menthol for a menthol-flavored hard candy. [0007] It can be surmised that a cooling agent or agents and the amounts of each can affect or interact with the mouth-moistening properties of other ingredients in the product in unpredictable ways that can only be determined based on evaluations. Moreover, the effect of the cooling agents on other properties such as mouth-moistening, as well as the effect of combining cooling agents and other ingredients on mouth-moistening and other sensory attributes such as refreshment must be researched and evaluated to obtain the most desirable product for consumers. [0008] U.S. Patent No. 2007/0031561 A l discloses a composition for a confectionery that imparts a mouth-moistening effect when orally consumed by an individual. More specifically, the composition is a blend of a sweetening composition, food-grade acid composition, and a cooling agent that reduces or eliminates the perception of mouth dryness in an individual. Such compositions can include hard candy as well as chewy candy, chewing gum, and center-filled candies. [0009] The mouth-moistening composition of U.S. Patent Pub. 2007/0031561 Al (Lakkis et al.) contains a relatively high amount of food-grade acid as well as a cooling agent system that avoids the use of menthol due to its bitterness. A high amount of food-grade acid can produce mouth moistening in the absence of menthol. In addition, food acid can exacerbate the potential bitterness of menthol. Also, high levels of acid can result in candies, especially hard candies, being more hygroscopic and less stable to moisture. [0010] Spilanthol is an alkylamide, (2E, 5Z, 8E)-deca-2,6,8-trienoic acid N-isobutyl amide, which can be found in the leaves and flowers of such plants as Spilanthes acmella. Spilanthol is known to have trigeminal and saliva-inducing effects. An oleoresin composition extracted from such plants, known as jambu, has been known as a "tingling sensate" for use in confectioneries.