Senior Scientific Team

SENIOR SCIENTIFIC TEAM

LabCorp® provides leading-edge diagnostic tests and services through a network of primary clinical laboratories and its specialty testing group. With scientific expertise in esoteric testing, genomics, clinical and anatomic pathology, and a commitment to comprehensive and high quality laboratory services, LabCorp delivers, accurate results for improved patient care. LabCorp clients include physicians, government agencies, managed care organizations, hospitals, clinical labs, and pharmaceutical companies. LabCorp employs a large scientific staff that includes MDs and PhDs available for testing support and consultation. This document includes a subset of key medical and scientific directors dedicated to LabCorp’s esoteric and genomic testing.

Chief Medical Officer Coagulation, Core Lab Identity Benjamin A. Nye, MT(ASCP)SH Uwe Heine, PhD Mark E. Brecher, MD André A. Valcour, PhD George C. Maha, JD, PhD

Chief Scientific Officer Coagulation, Esoteric Immunohematology Marcia Eisenberg, PhD Dorothy M. (Adcock) Funk, MD Mark E. Brecher, MD Laura McClannan Cytogenetics Medical and Scientific Directors Peter Papenhausen, PhD Immunohistochemistry Mark E. Brecher, MD Bing Huang, MD, PhD Kim Dickinson, MD, MBA, MPH Kim Dickinson, MD, MBA, MPH Evelyn Vazquez Marcia Eisenberg, PhD Esoteric Immunoassay James K. Fleming, PhD Kelly Y. Chun, PhD Immunology André A. Valcour, PhD Joe Adams Divisional Medical Directors Esoteric Microbiology Infectious Disease Immunology James B. Amberson, MD Barbara A. Body, PhD Mary Ann Meiser Alicia Carter, MD Kyle L. Eskue, MD Flow Cytometry Manual Microbiology Sean E. Farrier, MD Janita Hughes Douglas Howard David Engler, PhD Araceli B. Reyes, MD Horacio G. Vall, PhD Kevin M. Harvey, PhD Nathan Thomas Scanzillo, PhD Rita Stainback Praveena Yetur, MD Fluorescent in situ Hybridization Kathleen E. Richkind, PhD Mass Spectrometry Discipline Directors James H. Tepperberg, PhD Russell Phillip Grant, PhD Gregory Clark Janis Allergy Forensic Toxicology André A. Valcour, PhD Glynn Chaney Microarray Jennifer A Collins, PhD Stuart Schwartz, PhD Anatomic Pathology Prabhakaran Koteel, PhD James Amberson, MD Molecular Genetics and Alicia Carter, MD Hematology Genomics Betty M. Garvin Burns Narasimhan Nagan, PhD Biochemical Genetics Suzette Huguenin, PhD Hematopathology Molecular Infectious Disease Philip Wyatt, MD, PhD Cherie Hilborn Dunphy, MD Charles P. Cartwright, PhD Ronald Wayne Thomason, MD Jeannette M. Whitcomb, PhD Clinical Toxicology Histology/Cytology Ray Gegen Alicia Carter, MD Molecular Microbiology Karla B. Walker, PharmD Tiea L. Kesler Barbara A. Body, PhD Melinda B. Nye, PhD 1 SENIOR SCIENTIFIC TEAM

Molecular Oncology Routine Chemistry Special Chemistry/Endocrinology Li Cai, PhD Thomas S. Herman, PhD Donald Walt Chandler, PhD Henry Y. Dong, MD, PhD Nathan Thomas Scanzillo, PhD Randolph M. Young, PhD

Quality Control Satellite Labs and Waived Testing Specimen Quality Alexander L. Katayev, MD James Kyle Farquhar, PhD Mark Sharp Randolph M. Young, PhD Frank Ryan, PhD H. Thomas Spillman, PhD

Chief Medical Officer Mark E. Brecher, MD – Chief Medical Officer and Senior Vice President, LabCorp; Discipline Director, Immunohematology, LabCorp Office location: Burlington, NC | Office telephone: 336 436-5049 | E-mail address: [email protected] Dr Brecher is board certified in anatomic and clinical pathology and in blood banking and transfusion medicine. He earned his medical degree at the University of Chicago Pritzker School of Medicine, where he also completed residency training in anatomic and clinical pathology. He completed a blood banking and transfusion medicine fellowship at the Mayo Clinic.

Dr Brecher is a leader in the field of pathology. Prior to joining LabCorp, he served on the faculty of the Mayo Clinic Department of Laboratory Medicine and Pathology (1988 to 1992) and as vice chair of the Department of Pathology and Laboratory Medicine at the McLendon Clinical Laboratories, University of North Carolina Hospitals (1992 to 2009). Presently, he is an adjunct professor of pathology and laboratory medicine at the University of North Carolina.

Dr Brecher’s research has been published in a wide variety of journals, including the New England Journal of Medicine, The Lancet, and the Mayo Clinic Proceedings. He is a member of the editorial boards of Transfusion and Blood Therapies in Medicine and an associate editor of the Journal of Clinical Apheresis. He is the immediate past chair of the Department of Health and Human Services Advisory Committee on Blood Safety and Availability and a past president of the American Society for Apheresis. Dr Brecher is a member of the American College of Pathologists, the American Association of Blood Banks, the American Society of Hematology, the American Society for Apheresis, and the International Society of Cellular Therapy. Chief Medical Officer Marcia Eisenberg, PhD – Senior Vice President and Chief Scientific Officer, LabCorp Office location: Research Triangle Park, NC | Office telephone: 919-361-7760 | E-mail address: [email protected] Dr Eisenberg earned a PhD in molecular biology from the University of Kentucky. She was a National Institutes of Environmental Health Sciences fellow in Research Triangle Park, NC.

Dr Eisenberg has been a member of the Federal Bureau of Investigation’s Technical Working Group on DNA Analysis Methods, and she was an appointed member of the National DNA Advisory Board during its lifespan. She has been recognized and honored for her contributions to the advancement of forensic DNA testing. She currently holds certification in molecular genetics and molecular oncology, forensic DNA testing, and paternity testing from the New York State Department of Health.

Dr Eisenberg has been employed by LabCorp for 21 years. She was hired to convert the then-current diagnostic testing to polymerase chain reaction (PCR)-based testing, which had recently been acquired by Roche Biomedical Laboratories, Inc. Her key areas of expertise include test development, optimization, and automation; review of new tests, technologies, and platforms; and working with partners to transform their intellectual property into viable diagnostic assays.

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Medical and Scientific Directors Mark E. Brecher, MD – Chief Medical Officer and Senior Vice President, LabCorp; Discipline Director, Immunohematology, LabCorp Office location: Burlington, NC | Office telephone: 336 436-5049 | E-mail address: [email protected] See Dr Brecher’s biographical sketch on page 2.

Kim Dickinson, MD, MBA, MPH – Medical Director, Integrated Oncology; Discipline Director, Immunohistochemistry, LabCorp Office location: Irvine, CA | E-mail address: [email protected] Dr Dickinson is board certified in anatomic and clinical pathology. She received her medical degree from Hahnemann University in Philadelphia and completed her residency training and a surgical pathology fellowship at Los Angeles County-University of Southern California (LAC-USC). Dr Dickinson sits on the board for the California Society of Pathologists and is a member of the College of American Pathology, the American Society of Clinical Pathologists, and the Digital Pathology Association.

Marcia Eisenberg, PhD – Senior Vice President and Chief Scientific Officer, LabCorp Office location: Research Triangle Park, NC | Office telephone: 919-361-7760 | E-mail address: [email protected] See Dr Eisenberg’s biographical sketch on page 2.

James K. Fleming, PhD Vice President and Director, Department of Science and Technology, LabCorp Office location: Burlington, NC | Office telephone: 336-436-2375 | E-mail address: [email protected] Dr Fleming is board certified in clinical biochemistry. He earned a PhD in clinical pathobiology from the Medical University of South Carolina, where he also completed a postdoctoral fellowship in clinical biochemistry.

Dr Fleming has been part of the LabCorp organization since 1989, serving as vice president and director of the Department of Science and Technology and an associate director responsible for the administrative and technical operations of the Special Chemistry department at LabCorp’s Esoteric Testing laboratory. His current responsibilities include the determination of core laboratory diagnostic testing and platform decisions for LabCorp and the ongoing quality vigilance associated with all testing. These decisions incorporate improvements in workflow efficiencies through platform consolidations, cost containment strategies, and early assessment and adoption of cutting-edge technology.

Previously, Dr Fleming held an appointment as an associate professor at the Medical University of South Carolina and as a consultant to the government of Burma to upgrade the laboratory systems throughout that country. He served as member of the North Carolina Legislative Task Force on the Early Detection of Kidney Disease and on the Board of Registry. He once chaired the Clinical Chemistry Examination Committee.

Dr Fleming currently serves as a member of the Laboratory Working Group of the National Institutes of Health National Kidney Disease Education Program and as an invited lecturer for the American Society of Clinical Pathologists for numerous seminars and workshops.

Dr Fleming is a fellow of the Academy of Clinical Biochemistry, a clinical scientist with the American Society of Clinical Pathology, a member of the American Association for Clinical Chemistry, and a professional member of both the American Diabetes Association and the American Heart Association.

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Divisional Medical Directors Mark E. Brecher, MD – Chief Medical Officer, LabCorp Office location: Burlington, NC | Office telephone: 336 436-5049 | E-mail address: [email protected] See Dr Brecher’s biographical sketch on page 2.

James B. Amberson, MD – Vice President and Senior Medical Director, Dianon Pathology; Discipline Director, Anatomic Pathology, LabCorp Office location: Shelton, CT | Office telephone: 203-926-7158 | E-mail address: [email protected] Dr Amberson is board certified in anatomic pathology and cytopathology. He received his medical degree from The Johns Hopkins University School of Medicine and completed residency training in pathology at the New York Hospital-Cornell University Medical Center. Dr Amberson was a cytopathology fellow at Montefiore Medical Center, Bronx, NY. He also holds an MBA from Columbia University.

Dr Amberson was an assistant professor of pathology at the Cornell University School of Medicine from 1983 to 1989, after which time he became Dianon’s medical director. His area of expertise is uropathology, and he has authored articles on general pathology, urology, flow cytometry, and image cytometry that have been published in various medical and scientific journals.

Dr Amberson is a member of the American Medical Association, the College of American Pathologists, the American Society of Clinical Pathology, the International Academy of Pathology, and the Johns Hopkins Medical and Surgical Society.

Alicia Carter, MD – Medical Director, LabCorp Atlantic Division; Discipline Director, Anatomic Pathology and Histology/ Cytology, LabCorp Office location: Burlington, NC | Office telephone: (336) 436-6130 | E-mail address: [email protected] Dr Carter is board certified in anatomic and clinical pathology and cytopathology. She earned her medical degree at the University of North Carolina at Chapel Hill, where she also completed her residency and fellowship training.

In addition to her roles as medical director of LabCorp’s Atlantic division and discipline director of anatomic pathology and histology/cytology, Dr Carter participates in LabCorp’s National Office of Quality and Science under the direction of the chief medical officer. During her tenure at LabCorp, she has participated in the Scientific Management and Strategic Committee, where she has been involved in reviewing the competitive and breakthrough strategies and planning for cytology and women’s health issues.

Dr Carter is a member of the American Society of Cytopathology, the College of American Pathologists, and the American Society of Clinical Pathology.

Kyle L. Eskue, MD – Medical Director, Mid-America Division, LabCorp Office location: Dallas, TX | Office telephone: 713-561-4662 | E-mail address: [email protected] Dr Eskue is board certified in cytopathology and anatomic and clinical pathology. He earned his medical degree from the University of Texas Medical Branch at Galveston, where he also completed residency training in anatomic and clinical pathology. He completed a surgical pathology fellowship at Houston Methodist Hospital and a cytopathology fellowship at the MD Anderson Cancer Center in Houston.

Dr Eskue is the current chair of the College of American Pathologists (CAP) NewsPath editorial board and a member of the CAP Committee on Professional and Community Engagement. He is contracted with LabCorp to provide pathology services and to serve as a medical director.

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Sean E. Farrier, MD – Vice President of Pathology Services, LabCorp; Medical Director, Southeast Division, LabCorp Office location: Tampa, FL | Office telephone: 813-225-3835 | E-mail address: [email protected] Dr Farrier is board certified in anatomic and clinical pathology. He earned his medical degree from the University of South Florida. He completed residency training in the Department of Pathology, University of South Florida, Tampa General Hospital.

Dr Farrier has special interests in molecular biology and gastrointestinal pathology. He is a member of the College of American Pathologists and the American Society of Clinical

Pathologists. Upon completion of his residency in 1998, Dr Farrier joined Dianon Pathology, a member of the LabCorp Specialty Testing Group, and has practiced gastrointestinal pathology for Dianon/LabCorp since that time. He served as medical director of Dianon’s Tampa, Florida, laboratory from 2001 to 2004. He has served as medical director of LabCorp’s Southeast division since 2008.

Araceli B. Reyes, MD – Medical Director, Northeast Division, LabCorp Office location: Raritan, NJ | Office telephone: 908-526-2400 x 2903 | E-mail address: [email protected] Dr Reyes is board certified in anatomic and clinical pathology and cytopathology. She received her medical degree from the University of Santo Thomas, Manila, Philippines, where she also completed a clinical pathology residency. She completed residency training in anatomic and clinical pathology as well as a clinical medicine/immunopathology fellowship at the Albert Einstein College of Medicine, Bronx, New York.

Dr Reyes is a member of the College of American Pathologists.

Nathan Thomas Scanzillo, PhD – Medical Director, Central North Division, LabCorp; Discipline Director, Routine Chemistry, LabCorp Office location: Louisville, KY | Office telephone: 502-456-4700 x3626 | E-mail address: [email protected] Dr Scanzillo is a diplomate of the American Board of Clinical Chemistry (DABCC) and a fellow of the Academy of Clinical Biochemistry (FACB). He earned his PhD in clinical chemistry from Cleveland State University, where he also conducted research fellowships in conjunction with The Cleveland Clinic Foundation. He conducted training fellowships at St. Luke’s Hospital in Cleveland, Ohio.

Dr Scanzillo started his career with LabCorp in 1991. He has served as laboratory director for LabCorp’s Dublin, Ohio, Elmhurst, Illinois, and Livonia, Michigan, labs and technical director for LabCorp’s Central North division. He is a team leader for the College of American Pathologists’ Clinical Laboratory and Forensic Urine Drug Testing accreditation programs, a fellow of the National Academy of Clinical Biochemistry, a member of the College of American Pathologists’ Laboratory Accreditation Program Advisory Panel, and a member of the American Association for Clinical Chemistry.

Proveena Yetur, MD – Medical Director, West Division, LabCorp Location: Monrovia, CA | Telephone: 626-471-3500 | E-mail address: [email protected] Dr Yetur earned her medical degree at Kurnool Medical College, Kurnool, India. She completed postgraduate training in internal medicine and patient-oriented research with acute pre-eclamptic patients in the departments of obstetrics and gynecology and internal medicine at University of California, Irvine, and affiliated medical centers, where she also completed her anatomic and clinical pathology residency. She did a fellowship in cytopathology, fine-needle aspiration, and immunohistochemistry at the University of Southern California. She then obtained additional surgical pathology fellowship training in the areas of gynecologic, urologic, and gastrointestinal pathology at the University of Southern California Norris Cancer Center.

Dr Yetur has an extensive background in pathology with a specific passion for gynecologic pathology and cytopathology. She has been in private practice in Southern California with a large local pathology group since 1991 and on the medical staff of several Los Angeles-based hospitals. She has served on committees, including perinatal, gyncology, blood bank, surgical, infectious disease, and tumor board. In 1997, she was instrumental in starting and developing the anatomic pathology 5 SENIOR SCIENTIFIC TEAM

department (with a primary focus on gynecologic pathology) for a large independent lab in Southern California. While there, she served as the medical director and was the first to bring high-risk HPV E6-E7 RNA testing to Southern California in 2009.

Dr Yetur has been a distinguished member of the medical community in Orange and LA counties and has held several medical laboratory directorships. She is contracted with LabCorp to provide pathology services and serve as a medical director. Discipline Directors Allergy André A. Valcour, PhD – Discipline Director of Allergy, Coagulation (Core Lab), and Esoteric Immunoassay, LabCorp Office location: Burlington, NC | Office telephone: 336-436-3854 | E-mail address: [email protected] Dr Valcour is a diplomate of the American Board of Clinical Chemistry (DABCC), a fellow of the National Academy of Biochemistry (NACB), and is certified by the New York State Department of Health as a director of clinical chemistry, endocrinology, therapeutic drug monitoring, clinical toxicology, and serologic oncology. He earned a PhD in biochemistry from the University of Vermont and completed postdoctoral fellowship training in clinical chemistry at Hartford Hospital in Connecticut.

Dr Valcour serves as either national discipline director or co-discipline director of the following LabCorp programs: endocrinology, serologic and tumor markers, allergy, and hemostasis and thrombosis.

Dr Valcour is a member of the American Association for Clinical Chemistry.

Anatomic Pathology James B. Amberson, MD – Vice President and Senior Medical Director, Dianon Pathology; Discipline Director, Anatomic Pathology, LabCorp Office location: Shelton, CT | Office telephone: 203-926-7158 | E-mail address: [email protected] See Dr Amberson’s biographical sketch on page 4.

Biochemical Genetics Suzette Huguenin, PhD – Discipline Director, Biochemical Genetics, Labcorp Office location: Research Triangle Park, NC | Office telephone: 919-361-7279 | E-mail address: [email protected] Dr Huguenin is board certified in clinical molecular genetics and clinical biochemical genetics. She earned a PhD in human genetics from the University of Maryland, Baltimore. She completed postdoctoral fellowships at Cedars-Sinai Medical Center (University of California, Los Angeles Medical Genetics Intercampus Training Program) and Stanford University Medical Center.

Dr Huguenin joined LabCorp in 2005. She currently serves as technical director and discipline director of biochemical genetics. As such, her responsibilities include oversight of biochemical genetics activities at LabCorp’s Research Triangle Park facility.

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Philip Wyatt, MD, PhD – Discipline Director, Biochemical Genetics, Labcorp Office location: Santa Fe, NM | Office telephone: 505-438-2211 | E-mail address: [email protected] Dr Wyatt earned a PhD in human anatomy and human genetics from the University of Manitoba in Winnipeg, Canada, and a medical degree from the University of Kentucky. Before joining Integrated Genetics (formerly Genzyme Genetics), a member of the LabCorp Specialty Testing Group, in 2007, he had a lengthy career at North York General Hospital’s Regional Center in Toronto, Canada, ultimately serving as chief of the Department of Genetics and medical director of the Genetics Program. He also served as genetics section head for the Ontario Medical Association.

At Integrated Genetics, Dr Wyatt supervises all laboratory services, including biochemistry, cytogenetics, FISH, microarray, and noninvasive prenatal testing, for all of Integrated Genetics Santa Fe laboratory site.

Dr Wyatt is a fellow of the Human Biology Council and a member of the American Society of Human Genetics, the Association of Genetic Counselors of Ontario, the European Society of Human Genetics, the Association for Molecular Pathology, the International Society for Prenatal Diagnosis, and the Medical Screening Society.

Clinical Toxicology Ray Gegen – Associate Vice President and Discipline Director of Clinical Toxicology, LabCorp Office location: Burlington, NC | Office telephone: 336-436-3572 | E-mail address: [email protected] Mr Gegen holds inspector certification from the Substance Abuse and Mental Health Services Administration. He earned a bachelor’s degree in chemistry from Wichita State University. He has 35 years of experience in clinical toxicology and has been instrumental in the technical development of chromatography and mass spectrometry, particularly as those methodologies are applied in the areas of clinical and forensic toxicology.

Karla B. Walker, PharmD – Discipline Director, Clinical Toxicology, LabCorp Office location: New Brighton, MN | Office telephone: 651-636-7466, ext 6162 | E-mail address: [email protected] Ms Walker is a directorate of the American Board of Clinical Chemistry in toxicological chemistry and a fellow of the National Academy of Clinical Biochemistry. She has an undergraduate degree in medical technology from Minnesota State University, Mankato, and a doctorate in pharmacy from the University of Minnesota, Minneapolis, where she also completed a postdoctoral fellowship in pharmacokinetics.

Ms Walker has been with MedTox Laboratories Inc., a member of the LabCorp Specialty Testing Group, for more than 20 years. She is currently the director of clinical toxicology at MedTox. She is a member of the American Society of Clinical Pathologists, the American College of Clinical Pharmacists, the Midwest Association for Toxicology and TDM, and the American Association of Clinical Chemistry

Coagulation, Core Lab Benjamin A. Nye, MT(ASCP)SH – Discipline Director, Coagulation, Core Lab, LabCorp Office location: Elon, NC | Office telephone: 336-436-3089 | E-mail address: [email protected] Mr Nye holds certification as a specialist in hematology and medical technologist from the American Society for Clinical Pathology. He earned a BS in medical laboratory science at the University of Vermont. He has worked for LabCorp since 2005 and is currently a laboratory manager for the Atlantic division regional laboratory overseeing core chemistry, cell immunology, hematology, and immunohematology.

André A. Valcour, PhD – Discipline Director of Allergy, Coagulation (Core Lab), and Esoteric Immunoassay, LabCorp Office location: Burlington, NC | Office telephone: 336-436-3854 | E-mail address: [email protected] See Dr Valcour’s biographical sketch on page 6.

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Coagulation, Esoteric Dorothy M. (Adcock) Funk, MD – Medical Director of Coagulation and Discipline Director, Coagulation (Esoteric), LabCorp Office location: Englewood, CO | Office telephone: 720-568-4328 | E-mail address: [email protected] Dr Adcock is board certified in anatomic and clinical pathology. She earned her medical degree at Michigan State University and completed residency training in pathology at the University of Colorado. She has worked as an anatomical and clinical pathologist and has spent the last 25 years focused on hemostasis testing only. Her area of expertise is laboratory hemostasis with an emphasis on pre-examination variables, clinical consultation, teaching, and standard setting.

Dr Adcock is a current chair of the FDA Hematology and Pathology Devices Panel. She serves as an advisor (and was previously chairperson) for the Clinical Laboratory Standards Institute (CLSI) Consensus Committee on Hematology and is also chair of the CLSI Document Development Committee on von Willebrand testing. She chaired the CLSI committees on H21 (collection, transport, and processing of blood specimens for testing plasma-based coagulation assays) and H54 (procedures of validation of INR and local calibration of PT/INR systems). She serves on the College of American Pathologists (CAP) Phlebotomy Committee and is a previous member of the CAP Coagulation Resource Council. She is currently vice president of the North American Specialized Coagulation Laboratory Association. She is also a member of the American Society for Clinical Pathology and a past president of the American Thrombosis Association.

Dr Adcock has authored more than 60 peer-reviewed publications, multiple book chapters, and numerous coagulation-based laboratory guidelines.

Cytogenetics Peter Papenhausen, PhD – National Director of Cytogenetics, LabCorp Office location: Research Triangle Park, NC | Office telephone: 919-361-7778 | E-mail address: [email protected] Dr Papenhausen holds certification from the American Board of Medical Genetics. He earned a PhD from New York University and received postdoctoral fellowship training at Mt. Sinai Medical Center. Hisprimary areas of interest and expertise include cancer cytogenetics, uniparental disomy, and high-resolution single-nucleotide polymorphism (SNP) microarrays.

Dr Papenhausen is a fellow of the American College of Medical Genetics, and he has authored more than 150 abstracts and articles published in peer-reviewed journals.

Bing Huang, MD, PhD – National Director of Cytogenetics, LabCorp Office location: Monrovia, CA | Office telephone: 626-471-7504 | E-mail address: [email protected] Dr Huang is a fellow of the American College of Medical Genetics. He received a medical degree from Sun Yat-sen University of Medical Sciences, Guangzhou, China, and a PhD in human genetics from the Virginia Commonwealth University School of Medicine. He received fellowship training in the National Human Genome Research Institute’s medical genetics training program.

Dr Huang began working for Integrated Genetics (formerly Genzyme Genetics), a member of the LabCorp Specialty Testing Group, in 1996. As national director of cytogentics, Dr Huang provides technical, scientific, and administrative direction for a large volume cytogenetics laboratory with multiple specimen types (amniocentesis, blood, bone marrow, CVS, tissue, and solid tumor) and multiple procedures (chromosome analysis, FISH, preimplantation genetic diagnosis); supervises clinical cytogeneticists; trains and teaches technical staff; participates in the development, evaluation, and implementation of new diagnostic methods and new projects; oversees and signs out cases, including aCGH and SNP array reports; provides consultation to physicians regarding genetic services and case findings; makes presentations at internal and external conferences; attends regular meetings with clients; and leads and participates in company-wide committees for best practices, standardization, and process review.

Dr Huang is a member of the American Society of Human Genetics and a diplomat for the American Board of Medical Genetics.

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Esoteric Immunoassay Kelly Y. Chun, PhD – Discipline Director, Esoteric Immunology, LabCorp Office location: Calabasas Hills, CA | Office telephone: 818-876-1358 | E-mail address: [email protected] Dr Chun received her PhD in biochemistry from the Medical College of Wisconsin and trained as a postdoctoral fellow in laboratory medicine at Harvard Medical School. She has more than 20 years of experience in protein science and assay development and validation. She joined Esoterix in 2002 as a technical director. She oversees chemistry tests, endocrine immunoassays, and immunogenicity testing.

Over the years, Dr Chun has developed and validated a number of pivotal endocrine and autoimmune assays for pharmaceutical trial and clinical diagnostic use. She lectures on a national level and has authored articles and book chapters with a focus on endocrinology and immunogenicity. She is a member of the Endocrine Society, American Diabetes Association, and the American Association of Clinical Chemistry.

André A. Valcour, PhD – Vice President and Laboratory Director, Center for Esoteric Testing, LabCorp Office location: Burlington, NC | Office telephone: 336-436-3854 | E-mail address: [email protected] See Dr Valcour’s biographical sketch on page 6.

Esoteric Microbiology Barbara A. Body, PhD – Associate Vice President and National Director, Microbiology, Special Microbiology, Esoteric Immunology/Serology, Kidney Stone Analysis, and Routine Virology, LabCorp Office location: Burlington, NC | Office telephone: 336-436-3341 | E-mail address: [email protected] Dr Body has been a diplomate of the American Board of Medical and Molecular Microbiology since 1985. She received her PhD from the University of Kentucky. She completed a postdoctoral fellowship in infectious diseases at Washington University in St. Louis, Mo, and a clinical postdoctoral fellowship in clinical and public health microbiology at the Medical College of Virginia.

Dr Body was an assistant professor of pathology and an associate director of microbiology at the University of Virginia for 6 years. During her tenure at LabCorp, Dr Body has directed the microbiology, virology, reference microbiology, molecular microbiology, infectious disease and autoimmune immunology, HIV-hepatitis serology, cell immunology, and kidney stone programs.

Dr Body is a Clinical and Laboratory Standards Institute area committee member, M40 co-chair, and M54P subcommittee advisor. She is also a member of the Board of the American College of Microbiology, has served on special emphasis review panels for the National Institutes of Health, and frequently publishes in peer-reviewed journals.

Flow Cytometry Janita Hughes Douglas – Discipline Director, Flow Cytometry, LabCorp Office location: Burlington, NC | Office telephone: 336-436-3877 | E-mail address: [email protected] Ms Douglas holds certification as a medical technologist from the American Society of Clinical Pathology. She joined National Health Laboratories, which later merged with Roche Biomedical Laboratories to form LabCorp, in 1992 and has been with LabCorp ever since. She currently supervises the Cell Immunology/Flow Cytometry lab at LabCorp’s York Court facility

Horacio G. Vall, Doctor of Biochemistry – Associate Vice President of Science and Technology, Integrated Oncology; Discipline Director, Flow Cytometry, LabCorp Office location: Irvine, CA | Office telephone: 919-450-0145 | E-mail address: [email protected] Dr Vall is a board-certified clinical laboratory scientist (CLS) and holds a Qualification in Cytometry (QCYM) certification from the American Society for Clinical Pathology. He received his doctorate at the National University of Rosario, Argentina. Prior to

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joining Integrated Oncology (formerly US LABS), a member of the LabCorp Specialty Testing Group, Dr Vall served for 3 years as vice president of laboratory services at Clarient, Inc., where he was responsible for developing and implementing specific tests on flow cytometry, molecular oncology, and FISH using conventional and new ways to improve laboratory’s efficiencies and work flow. Prior to that, Dr Vall worked for Genzyme (formerly Impath) for 8 years, where, as the corporate technical director for high complexity testing, he was responsible for new technologies involving flow cytometry, image analysis, and complex molecular-based testing. He was also responsible for the overall management of all clinical laboratory testing, operations, and test development for the division, and led the QA & QC team in assessment and development of the product pipeline and technology utilization.

During the early1990s Dr Vall worked on leukemia-lymphoma flow cytometry analysis and helper/suppressor studies in transplant patient for drug monitoring, conducted studies on immunodeficiency patients using flow cytometry and performed stem cell studies for autologous bone marrow transplants at both Loma Linda University Medical Center and City of Hope National Medical Center.

Dr Vall is a member of the Clinical Cytometry Society and the Rheumatoid Society.

Fluorescent in situ Hybridization Kathleen E. Richkind, PhD – Discipline Director, Fluorescent in situ Hybridization, LabCorp Office location: Santa Fe, NM | Office telephone: 505-438-2120 | E-mail address: [email protected] Dr Richkind is board certified in clinical genetics. She earned her PhD in genetics from the University of California, Los Angeles. She completed postdoctoral fellowship training at the City of Hope National Medical Center, Division of Cytogenetics/Cytology, in Duarte, California.

Dr Richkind joined Integrated Genetics (then Vivigen) in 1982. Integrated Genetics is a member of the LabCorp Specialty Testing Group, and Dr Richkind serves as a director in its Santa Fe, New Mexico, laboratory.

Dr Richkind has authored or coauthored numerous scientific manuscripts, book chapters, and scientific presentations. She is a founding fellow of the American College of Medical Genetics and a member of the American Society of Human Genetics.

James H. Tepperberg, PhD – Technical Director, Cytogenetics and Discipline Director for FISH, LabCorp Office location: Research Triangle Park, NC | Office telephone: 919-361-7783 | E-mail address: [email protected] Dr Tepperberg holds board certification in cytogenetics from the American Board of Medical Genetics and in cytogenetics and oncology molecular detection from the New York State Department of Health. He earned a PhD in genetics and developmental biology from West Virginia University with thesis research at Duke University. He received his postdoctoral training in cytogenetics at the University of North Carolina at Chapel Hill.

Dr Tepperberg’s responsibilities at LabCorp include chromosome/ FISH diagnosis and interpretation of prenatal, postnatal, and oncology samples; development and expansion of FISH and single-nucleotide polymorphism (SNP) microarray techniques and analysis; and literature review for related cytogenetic cases.

Dr Tepperberg is a fellow of the American College of Medical Genetics and a member of the American Society of Human Genetics. He has authored a number or articles and abstracts that have appeared in peer-reviewed publications.

Forensic Toxicology Glynn Chaney – Vice President and Director, Medical Drug Monitoring; Discipline Director, Forensic Toxicology, LabCorp Office location: Research Triangle Park, NC | Office telephone: 727-482-7873 | E-mail address: [email protected] Mr Chaney holds certification as a toxicological chemist from the National Registry of Certified Chemists. He earned a master of science degree in technology management from Mercer University in Atlanta, Georgia.

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Mr Chaney has comprehensive experience in analytical toxicology methods, theory, and instrumentation with emphasis in mass spectrometry, chromatography (GC, HPLC, SPE, TLC), and immunoassay. His management experience and skills encompass technical operations, product development, and sales in complex, competitive and service intensive business disciplines. He first joined LabCorp 1999 as a toxicology laboratory director in Tampa, Florida.

Mr Chaney is a substance abuse and mental health services (SAMHSA) inspector for the National Laboratory Certification Program, a forensic urine drug testing (FUDT) inspector for the College of American Pathologists, and a member of the Society of Forensic Toxicologists and the Society of Hair Testing.

Jennifer A Collins, PhD – Divisional Director, Forensic Toxicology, LabCorp Office location: St. Paul, MN | Office telephone: 651-628-6113 | E-mail address: [email protected] Dr Collins is a diplomate of the American Board of Forensic Toxicology and holds certification as a high-complexity laboratory director (HCLD) from the American Board of Bioanalysis. She earned her PhD from Northwestern University and a Pubic Health Certificate in Core Concepts (PHCert-CC) from the University of Minnesota. She is currently the laboratory director of MedTox Laboratories, a member of the LabCorp Specialty Testing Group. She joined MedTox in 1994.

Dr Collins serves as a laboratory inspector for the College of American Pathologists (CAP) Forensic Drug Testing Accreditation Program the Substance Abuse and Mental Health Services Administration (SAMHSA) National Laboratory Certification Program. She is a member of the American Association of Clinical Chemistry (AACP) and the Society of Forensic Toxicologists. She serves as an AACC liaison to the CAP Toxicology Resource Committee and is on the editorial advisory board of Clinical and Forensic Toxicology News.

Prabhakaran Koteel, PhD – Discipline Director, Forensic Toxicology, LabCorp Office location: Houston, TX | Office telephone: 713-856-8288, ext 3653 | E-mail address: [email protected] Dr Koteel earned his PhD in analytical chemistry from Marquette University in Milwaukee, Wisconsin. As a technical director for Damon Clinical laboratories from 1981 to 1992, Dr Koteel was responsible for the clinical chemistry, hematology, serology, cytology, special chemistry, and toxicology areas. He successfully planned and directed a US Navy drug screening bid, and he planned and directed a major HIV-Ab testing project for the US Army Reserves that involved testing 6000 specimens per day. From 1992 to 1998, Dr Koteel directed Quest Diagnostics’ Tampa and Deerfield, Florida, laboratories with management responsibilities for the clinical chemistry, hematology, serology, cytology, histology, toxicology, and special chemistry departments.

Dr Koteel joined LabCorp in 2003 and began specializing in forensic toxicology. He is the director of LabCorp’s Substance Abuse and Mental Health Services Administration (SAMHSA)-certified occupational testing laboratory in Houston where his primary responsibilities include overseeing the day-to-day operations of the laboratory, which performs workplace and pain management testing; certification of both positive and negative results; providing expert witness testimony; and communicating information about the lab’s operation, analytical procedures, and positive drug test results. He is also the technical director for LabCorp’s Point-of-Care Testing program.

Dr Koteel is a National Laboratory Certification Program inspector for federally-approved SAMHSA laboratories. He has been published in various toxicology-related journals and books. He is a full-time member of the Society of Forensic Toxicology and the American Association of Clinical Chemistry.

Hematology Betty M. Garvin Burns – Discipline Director, Hematology, LabCorp Office location: Burlington, NC | Office telephone: 336-436-3309 | E-mail address: [email protected] Ms Burns holds certification from American Society for Clinical Pathology Board of Registry in the following categories: medical laboratory technician (MLT), medical technologist (MT), and specialist in hematology (SH). She has 30 years of combined

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hospital, outpatient clinic, and reference laboratory experience as a generalist in all disciplines of the clinical laboratory, with specialty expertise in hematology and routine coagulation/hemostatis-thrombosis.

Ms Burns’ current responsibilities include managing the regional hematology, urinalysis, and immunohematology departments for LabCorp’s Atlantic Division. In addition, as the national discipline director for hematology, urinalysis, and semen analysis, Ms Burns oversees new testing platform evaluations, implementations, procedures, policies, and standardization. She also serves as a technical consultant for LabCorp regarding hematology testing and practices.

Ms Burns has participated as an inspector for numerous College of American Pathologists (CAP) inspections and internal laboratory audits in LabCorp facilities for corporate quality assurance and regulatory compliance.

Hematopathology Cherie Hilborn Dunphy, MD – Director of Hematopathology, LabCorp Office location: Research Triangle Park, NC | Office telephone: 919-361-7289 | E-mail address: [email protected] Dr Dunphy is certified by the American Board of Pathology in hematology and anatomic and clinical pathology (AP/CP). She earned her medical degree and completed AP/CP residency training at the Louisiana State University School of Medicine in Shreveport. She completed a surgical pathology fellowship at the University of Texas, M. D. Anderson Hospital and Tumor Institute in Houston. Dr Dunphy has practiced diagnostic hematopathology exclusively for more than 20 years, has served on numerous College of American Pathologists committees, and was the director of hematopathology at the University of North Carolina-Chapel Hill for more than 11 years before joining LabCorp. She is the author of more than 125 peer-reviewed articles, numerous book chapters, as well as several published books, including Integrated Hematopathology, which was named to the highly esteemed Doody’s Core Titles, Essential Collection, in the Health Sciences. Dr Dunphy currently reviews numerous articles, sits on the editorial boards of Modern Pathology, International Journal of Medical and Biological Frontiers, and Archives of Pathology and Laboratory Medicine, and is chief editor of the hematopathology section of eMedicine.

Ronald Wayne Thomason, MD – Director of Hematopathology, Integrated Oncology and Dianon Pathology; Medical Director, Integrated Oncology; Discipline Director, Hematopathology, LabCorp Office location: Brentwood, TN | Office telephone: 615-377-7149 | E-mail address: [email protected] Dr Thomason is board certified in anatomic and clinical pathology and hematopathology. He earned his medical degree with highest honors from the University of Tennessee School of Medicine. He completed residency training in anatomic and clinical pathology at Wilford Hall Medical Center at Lackland Air For ce Base in Texas and completed a hematopathology fellowship directed by Dr Peter Banks at the University of Texas Health Science Center at San Antonio.

Dr Thomason has practiced pathology since 1995. He practiced general pathology with an emphasis on hematopathology for 7 years, and for the past 7 years he has been a hematopathologist. Previously, Dr Thomason was medical director of hematology and a staff pathologist in the Department of Pathology at Blount Memorial Hospital in Maryville, Tenn, and medical director of Molecular Pathology Laboratory, also in Maryville, Tenn.

Dr Thomason is a member of the American Society of Clinical Pathologist, the American Society of Hematology, and the International Society for Analytic Cytometry.

Histology/Cytology Alicia Carter, MD – Medical Director, LabCorp Atlantic Division; Discipline Director, Anatomic Pathology and Histology/ Cytology, LabCorp Office location: Burlington, NC | Office telephone: (336) 436-6130 | E-mail address: [email protected] See Dr Carter’s biographical sketch on page 4.

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Tiea L. Kesler – Vice President and Director of Histology/Cytology, LabCorp Office location: Burlington, NC | Office telephone: 336-436-6106 | E-mail address: [email protected] Ms Kesler holds certification from American Society for Clinical Pathology (ASCP) Board of Registry as a cytotechnologist (CT). She has 28 years of experience in the field of cytology. She currently serves as discipline director for cytology, histology, and anatomic pathology quality and provides additional support for all of LabCorp’s cytology and histology services. She is also responsible for quality assurance (including standardization of equipment, reagents, new test development, and validation) and credentialing (approval and continuous tracking of pathologists, PhDs, cytotechnologists, histotechnologists, grossers, pathology assistants, and genetic counselors).

Ms Kesler is a member of the ASCP, the American Society of Cytopathology, the National Society of Histotechnology, and the American Society of Cytotechnology.

Identity Uwe Heine, PhD – Associate Vice President and Technical Director of DNA Identification Testing Division, LabCorp Office location: Burlington, NC | Office telephone: 336-436-7308 | E-mail address: [email protected] Dr Heine received his PhD from the Department of Microbiology at Indiana University in Bloomington. His research focus was regulation of gene expression in Caenorhabditis elegans. Dr Heine’s postdoctoral research in regulation of viral DNA replication was performed at the Department of Biological Chemistry at Harvard Medical School, and he continued as a research fellow at the Roche Institute of Molecular Biology in Nutley, New Jersey.

Dr Heine took a position with LabCorp (then Roche Biomedical Laboratories) in 1989 as an associate director with responsibility for the DNA testing section of the paternity laboratory. Since that time, Dr Heine has developed and validated PCR-based procedures for human identification and HLA typing. Dr Heine is the principal investigator for LabCorp’s contract with the National Marrow Donor Program (NMDP) to HLA type volunteer stem cell donors for the national registry. He as held this position continuously since 1997.

Dr Heine is certified as a laboratory director by the State of New York Department of Health in the categories of histocompatibility, parentage/identity testing, and posttransplant engraftment monitoring.

George C. Maha, JD, PhD – Associate Vice President, Laboratory Director, and Technical Leader of the DNA Identification Testing Division, LabCorp Office location: Burlington, NC | Office telephone: 336-436-7307 | E-mail address: [email protected] Dr Maha is a diplomate of the American Board of Medical Genetics in the category of PhD medical geneticist. He is also certified as a medical technologist (MT) by the American Society of Clinical Pathologists (ASCP) and as a laboratory director by the New York State Department of Health in the categories of clinical chemistry, forensic identity, genetic testing, histocompatibility, immunohematology, parentage/identity testing, and transplant monitoring.

Dr Maha received his PhD from the Department of Genetics and Development at the University of Illinois at Urbana-Champaign and his JD from the North Carolina Central University School of Law in Durham. He also completed a biomedical laboratory internship at Malcolm Grow USAF Medical Center.

Dr Maha was an observer to the National Conference of Commissioners on Uniform State Laws’ revision of the Uniform Parentage Act, was vice chair of the Paternity Committee of the American Bar Association’s Family Law Section, and was chair of—and is currently a consultant to—the Relationship Testing Standards Program Unit for AABB. Dr Maha is also a consultant to the Histocompatibility/Identity Testing Committee of the College of American Pathologists.

Dr Maha has been admitted as an expert in genetic testing in more than 100 trials in 24 states. He has published and given numerous presentations on various scientific and legal aspects of relationship testing and histocompatibility testing, including pregnancy tests through transplant monitoring and scientific and legal aspects of paternity/relationship testing. 13 SENIOR SCIENTIFIC TEAM

Immunohematology Mark E. Brecher, MD – Chief Medical Officer and Senior Vice President, LabCorp; Discipline Director, Immunohematology, LabCorp Office location: Burlington, NC | Office telephone: 336 436-5049 | E-mail address: [email protected] See Dr Brecher’s biographical sketch on page 2.

Laura McClannan – Vice President, National Office of Quality; Discipline Director, Immunohematology, LabCorp Office location: Burlington, NC | Office telephone: 336-436-6281 | E-mail address: [email protected] Ms McClannan earned a master’s degree in clinical laboratory science-immunohematology from the University of Alabama. She holds certification from the American Society for Clinical Pathology (ASCP) Board of Registry as a medical technologist (MT) and specialty certification in blood banking (SBB). She also holds certification from the American Society of Quality (ASQ) as a quality auditor (CQA).

Ms McClannan’s areas of expertise are blood banking, cellular therapy, and quality management. She has 25 years of experience in transfusion medicine. For 19 years, she served at the University of North Carolina Hospitals as the Assistant Administrative Director for Transfusion Medicine and Transplant Service Laboratories, Quality Management, and Laboratory Information Systems. She has experience as an assessor for blood bank and cellular therapy laboratories.

Ms McClannan has been actively involved on committees of the AABB and is a former chair of the Cellular Therapy Accreditation Program Unit and a member of the Cellular Therapy Standards Program Unit for the AABB.

Immunohistochemistry Kim Dickinson, MD, MBA, MPH – Medical Director, Integrated Oncology; Discipline Director, Immunohistochemistry, LabCorp Office location: Irvine, CA | E-mail address: [email protected] See Dr Dickinson’s biographical sketch on page 3.

Evelyn Vazquez Immunology Joe Adams – Joe Adams Office location: Dublin, OH | Office telephone: 614-889-1061, ext 3245 | E-mail address: [email protected] Mr Adams holds certification as a specialist in immunology from the American Society for Clinical Pathology. He has been with LabCorp for more than 3 decades. His areas of expertise include immunology, flow cytometry, and special chemistry. Mr Adams is a member of the Association of Medical Laboratory Immunologists.

Infectious Disease Immunology Mary Ann Meiser – Director of Esoteric and Core Laboratories and Director of Infectious Disease Immunology, LabCorp Office location: Raritan, NJ | Office telephone: 908-526-2400 x2272 | E-mail address: [email protected] Ms Meiser holds certification from the American Society for Clinical Pathology (ASCP) Board of Registry as a medical technologist (MT). She has 30 years of management experience with LabCorp.

Currently, Ms Meiser is the director of LabCorp’s core and esoteric laboratories, a multi-discipline position over the chemistry, hematology, immunology, and immunoassay labs, which also includes flow and hepatitis/HIV screening. She is also a discipline director of infectious disease immunology and has been on many hepatitis committees.

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Manual Microbiology Howard David Engler, PhD – Technical Director; Discipline Director, Manual Microbiology, LabCorp Office location: Raritan, NJ | Office telephone: 908-526-2400 x2892 | E-mail address: [email protected] Dr Engler is a diplomate of the American Board of Medical Microbiology. He earned his PhD in medical microbiology and immunology from The Ohio State University. He completed postdoctoral fellowship training medical and public health laboratory microbiology at the Mt. Sinai Medical Center.

Dr Engler has served as technical director of microbiology and immunology at Focus Technologies, senior staff microbiologist at the National Institutes of Health, director of clinical virology at Hackensack Medical Center, and assistant director of clinical microbiology at Mt. Sinai Hospital. He is currently responsible for the technical and administrative operation of the LabCorp Raritan, NJ, microbiology, urinalysis, and molecular diagnostics departments, employing a technical and support staff of approximately 140 people. He also functions as the corporate co-discipline director responsible for routine microbiology. His areas of expertise include clinical microbiology, clinical virology, and antimicrobial susceptibility.

Dr Engler is a member of the American Society for Microbiology. His licensures include Laboratory Director, New York Department of Health and Bioanalytical Laboratory Director, New Jersey Board of Medical Examiners. He has authored a number of abstracts and articles that have been published in peer-reviewed journals.

Kevin M. Harvey, PhD – Discipline Director, Manual Microbiology, LabCorp Office location: Dublin, OH | Office telephone: 614-889-1061 | E-mail address: [email protected] Dr Harvey is a diplomate of the American Board of Medical Microbiologists. He earned his PhD in medical microbiology and immunology at The Ohio State University, Columbus. He was a postdoctoral fellow in clinical microbiology and public health at the Medical College of Virginia, Richmond, where his research involved mechanisms of antibiotic resistance to beta-lactams and urinary tract infections.

Dr Harvey has worked for LabCorp since 2004. He serves as technical director of microbiology for the North Central division, where his duties include technical direction of the bacteriology, parasitology, virology, mycology, and mycobacteriology and serology sections, supervising 40 full-time employees, and interacting with physicians and other medical providers and clients in the Great Lakes region of LabCorp. He is also the director of LabCorp STAT labs in Pittsburgh, Pennsylvania and Willoughby, Ohio. His responsibilities in those labs include consultation of test results, review of quality assurance/quality control processes, participation in the selection and evaluation of laboratory equipment, and interacting with federal, state, local authorities and other regulatory agencies.

Dr Harvey is a member of the American Society for Microbiology and has authored articles published in peer-reviewed scientific journals.

Rita Stainback, MS, MT (ASCP), SM, DLM – Discipline Director, Manual Microbiology, LabCorp Office location: Burlington, NC | Office telephone: 336-436-3955 | E-mail address: [email protected] Ms Stainback holds certification from American Society for Clinical Pathology Board of Registry in the following categories: medical technologist, microbiology, and diplomate in laboratory medicine. She earned a master of science degree in microbiology from the University of Rochester.

Ms Stainback has more than 30 years of experience in the clinical laboratory industry, including 20 years of hospital-based microbiology experience. She is the manager of LabCorp’s microbiology and kidney stone laboratories.

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Mass Spectrometry Russell Phillip Grant, PhD – Strategic Director and National Director of Mass Spectrometry, LabCorp Office location: Burlington, NC | Office telephone: 336-436-3605 | E-mail address: [email protected] Dr Grant earned a PhD in chromatographic and mass spectrometric technologies from the University of Swansea, Wales, United Kingdom. He continued his scientific training in various industrial settings, which have included senior scientist at GSK, principal scientist at Cohesive Technologies, technical director at Eli Lilly, and director of mass spectrometry at Esoterix Endocrinology.

Dr Grant has pioneered the use of direct injection technologies, chromatographic systems multiplexing, utility of automation, and new analytical platforms for application in bioanalytical applications. His research goals are focused upon improvements in speed, sensitivity, and quality of liquid chromatography with tandem mass spectrometric (LC-MS/MS) analytical systems and assays.

Dr Grant serves as clinical chemistry chair for the American Society of Mass Spectrometry and is a member of the American Association for Clinical Chemistry.

Gregory Clark Janis – R&D Technical Director; Director of Mass Spectrometry, LabCorp Office location: St. Paul, MN | Office telephone: 651-628-6190 | E-mail address: [email protected] Mr Janis earned undergraduate degrees in biochemistry and chemistry at Virginia Tech and an MS in toxicology at University of North Carolina. He has 2 decades of experience developing techniques for the analysis of pharmaceuticals and drugs of abuse. Current interests include high-throughput mass spectrometry screening techniques, as well as the identification and analysis of new and emerging drugs of abuse. He is a member of the American Society for Mass Spectrometry and the Society for Forensic Toxicologists.

Microarray Stuart Schwartz, PhD – Discipline Director, Microarray, LabCorp Office location: Research Triangle Park, NC | Office telephone: 919-572-7415 | E-mail address: [email protected] Dr Schwartz is board certified in medical genetics, clinical cytogenetics, and clinical molecular genetics. He earned a PhD in medical genetics from Indiana University and completed a postdoctoral fellowship at the University of Maryland School of Medicine. His major areas of interest include molecular cytogenetics, the delineation and characterization of neocentromeres, phenotype/karyotype correlation in the 9p deletion syndrome, the etiology of structural chromosome abnormalities, the characterization of de novo and complex reciprocal translocations, and high-resolution chromosome methodology. In addition to authoring a number of book chapters, Dr Schwartz has authored more than 160 articles for peer-reviewed journals.

Molecular Genetics and Genomics Narasimhan Nagan, PhD – Discipline Director, Molecular Genetics and Genomics, LabCorp Office location: Westborough, MA | Office telephone: 508-389-8351 | E-mail address: [email protected] Dr Nagan is a fellow of the American College of Medical Genetics and the National Academy of Clinical Biochemistry, and he is board certified by the American Board of Clinical Chemistry. He earned his PhD at Boston University and did postdoctoral training at the Boston University School of Medicine and Mayo Clinic.

Since 2007, Dr Nagan has served as clinical laboratory director of Integrated Genetics (formerly Genzyme Genetics), a member of the LabCorp Specialty Testing Group. His current areas of research interest include applications of molecular diagnostic techniques in the clinical laboratory; introduction and development of new tests and clinical utilization/optimization/test validation and standardization of laboratory testing; clinical interpretation and reporting of novel variants identified by sequencing; genotype/phenotype correlations and population based screening in genetic disorders.

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Dr Nagan has authored several articles published in peer-reviewed journals. He holds published patents for methods of detecting mutations associated with ataxia oculomotor apraxia (AOA2), identification of a novel gene underlying familial spastic paraplegia, and mutations associated with cystic fibrosis. He is a member of the Association for Molecular Pathology and the American Society for Human Genetics.

Molecular Infectious Disease Charles P. Cartwright, PhD – Vice President; Discipline Director, Molecular Infectious Disease, LabCorp Office location: Burlington, NC | Office telephone: 336-436-6448 | E-mail address: [email protected] Dr Cartwright earned his doctorate in microbiology from the University of Bath in the United Kingdom. He received postdoctoral training in the area of molecular microbiology at Yale University School of Medicine and the University of Massachusetts Medical School and trained as a fellow in clinical microbiology at the National Institutes of Health.

Since 2006, Dr Cartwright has served as chief scientific and technical director of ViroMed Laboratories, a member of the LabCorp Specialty Testing Group. Before joining ViroMed, he served as medical director of clinical microbiology and molecular diagnostics at Hennepin County (Minnesota) Medical Center and the Veterans Affairs Medical Center. Dr Cartwright has published more than 50 papers in peer-reviewed journals and holds a published patent for the molecular detection of Mycobacterium avium complex. He is a member of the American Society for Microbiology, the Academy of Clinical Laboratory Physicians and Scientists, and the Association for Molecular Pathology, and he sits on the editorial board for the Journal of Clinical Microbiology.

Jeannette M. Whitcomb, PhD – Discipline Director, Molecular Infectious Disease, LabCorp Office location: South San Francisco, CA | Office telephone: 650-866-7433 | E-mail address: [email protected] Dr Whitcomb earned a PhD in microbiology and immunology at the Temple University School of Medicine in Philadelphia. She was did postdoctoral fellowships at the Swiss Institute for Experimental Cancer Research in Lausanne, Switzerland, and the National Cancer Institute at Frederick, Maryland.

Dr Whitcomb has served as vice president of operations at Monogram Biosciences, a member of the LabCorp Specialty Testing Group, since 2003. Her work has been published extensively in peer-reviewed scientific journals.

Molecular Microbiology Barbara A. Body, PhD – Associate Vice President and National Director, Microbiology, Special Microbiology, Esoteric Immunology/Serology, Kidney Stone Analysis, and Routine Virology, LabCorp Office location: Burlington, NC | Office telephone: 336-436-3341 | E-mail address: [email protected] See Dr Body’s biographical sketch on page 9.

Melinda B. Nye, PhD – Associate Vice President and Director of Molecular Microbiology, LabCorp Office location: Burlington, NC | Office telephone: 336-436-3760 | E-mail address: [email protected] Dr Nye is a board-certified medical technologist and a diplomate of the American Board of Medical and Public Health Microbiology. She earned a PhD in microbiology and immunology from Dartmouth College, Hanover, New Hampshire, and completed a postdoctoral fellowship in medical and public health microbiology from the University of Rochester Medical Center in New York.

Dr Nye is interested in all aspects of the diagnosis of infectious disease, but her primary focus is on molecular detection. Her particular area of expertise is in the diagnosis of sexually transmitted infections. In addition to her other roles at LabCorp, Dr Nye is also a discipline director for molecular microbiology.

Dr Nye is a member of the American Society for Microbiology, the Pan American Society for Clinical Virology, the Southeastern Association for Clinical Microbiology, and the Association for Molecular Pathology. 17 SENIOR SCIENTIFIC TEAM

Molecular Oncology Li Cai, PhD – Discipline Director, Molecular Oncology, LabCorp Office location: Research Triangle Park, NC | Office telephone: 919-361-7179 | E-mail address: [email protected] Dr Cai is board certified in clinical molecular genetics and holds certification in molecular genetic testing and oncology (molecular and cellular tumor markers) from the New York State Department of Health. She earned a PhD in genetics from Texas A&M University. She completed a research fellowship in clinical molecular genetics at Harvard Medical School, during which time she received the National Institutes of Health Individual Research Award for her work on cloning the PXE gene.

At LabCorp, Dr Cai is a geneticist and discipline director of the molecular oncology laboratory at the Center for Molecular Biology and Pathology. She is responsible for assay review, result sign-out, quality assurance, new test development and evaluation, day- to-day management of the laboratory operation, physician consultation, and internal and external education efforts.

Dr Cai has published articles and books about her research, and she holds patents for her gene discovery research.

Henry Y. Dong, MD, PhD – Discipline Director, Molecular Oncology, LabCorp Office location: New York, NY | Office telephone: 212-485-0758 | E-mail address: [email protected] Dr Dong is board certified in anatomic pathology and hematopathology. He earned his medical degree from Beijing Medical University and his PhD in molecular cell biology from the Albert Einstein College of Medicine. He was a postdoctoral research fellow at the Dana Farber Cancer Institute. Dr Dong completed his pathology residency at Massachusetts General Hospital followed by a Vickery fellowship in surgical pathology and a James Homer fellowship in hematopathology.

Dr Dong is the director of hematopathology and molecular pathology for Integrated Genetics (formerly Genzyme Genetics), a member of the LabCorp Specialty Testing Group, in New York. He has been with Integrated Genetics since 2004. He has played critical roles in the development of new molecular products for Integrated Genetics and has published a number of peer- reviewed articles on hematopathology and molecular testing in prominent pathology and hematology journals.

Quality Control Alexander L. Katayev, MD – Discipline Director, Quality Control, LabCorp Office location: Elon, NC | Office telephone: 336-436-2314 | E-mail address: [email protected] Dr Katayev earned his medical degree at the Leningrad Institute of Medicine and Hygiene, Leningrad, Russia. He serves as LabCorp’s director of clinical science assessment in the Department of Science and Technology. He is a member of the American Society for Clinical Pathology.

Randolph M. Young, PhD – Vice President of Operations and National Director, Special Chemistry, LabCorp Office location: Burlington, NC | Office telephone: 336-436-3460 | E-mail address: [email protected] Dr Young earned his PhD in clinical chemistry from Cleveland State University. He completed postdoctoral fellowship training at the Cleveland Clinic.

At LabCorp, Dr Young has served as director of the routine chemistry, special chemistry, hematology, and immunoassay departments; national special chemistry discipline director; national quality control director; and national quality assurance director.

Dr Young is a member of the American Society for Clinical Chemistry.

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Routine Chemistry Thomas S. Herman, PhD – Discipline Director, Routine Chemistry, LabCorp Office location: Tampa, FL | Office telephone: 813-225-3825 | E-mail address: [email protected] Dr Herman holds the following certifications: Diplomate, American Board of Clinical Chemistry; Specialist in Chemistry, American Society of Clinical Chemists; Clinical Chemist, National Registry of Clinical Chemists; Clinical Laboratory Director, Georgia Department of Human Resources; Clinical Laboratory Director, Florida Department of Health and Rehabilitative Services. He earned a master of science degree in microbiology and a PhD in clinical chemistry at Ohio State University.

Dr Herman has been employed by LabCorp since 1987. He is a Member of the American Association for Clinical Chemistry, the Clinical Laboratory Management Association, and the American Society of Clinical Pathologists.

Nathan Thomas Scanzillo, PhD – Medical Director, LabCorp Central North Division; Discipline Director, Routine Chemistry, LabCorp Office location: Louisville, KY | Office telephone: 502-456-4700 x3626 | E-mail address: [email protected] Dr Scanzillo is a diplomate of the American Board of Clinical Chemistry (DABCC) and a fellow of the Academy of Clinical Biochemistry (FACB). He earned his PhD in clinical chemistry from Cleveland State University, where he also conducted research fellowships in conjunction with The Cleveland Clinic Foundation. He conducted training fellowships at St. Luke’s Hospital in Cleveland, Ohio.

Satellite Labs and Waived Testing James Kyle Farquhar, PhD – Discipline Director, Satellite Labs and Waived Testing, LabCorp Office location: San Antonio, TX | Office telephone: 210-735-9461 x3200 | E-mail address: [email protected] Dr Farquhar is a board-certified clinical chemist. He earned a PhD in health services management from Century University.

Dr Farquhar has several decades of experience in laboratory medicine, including expertise in toxicology, Clinical Laboratory Improvement Amendments (CLIA) regulations, and technical customer service. He currently serves as the associate vice president, technical director, and EHS/regulatory director for LabCorp’s Southwest division.

Dr Farquhar is a member of the American Association for Clinical Chemistry.

Frank Ryan, PhD – Discipline Director, Satellite Labs and Waived Testing, LabCorp Office location: Englewood, CO | Office telephone: 720-568-4406 | E-mail address: [email protected] Dr Ryan is a diplomate of the American Board of Clinical Chemistry (DABCC). He earned a PhD in biochemistry from the University of Washington, where he also conducted a National Cancer Institute fellowship.

Dr Ryan serves as LabCorp’s discipline director for automated chemistry, and he is the director of 5 of LabCorp’s regional labs in Colorado, Arizona, and Nevada.

Dr Ryan is a member of the American Association for Clinical Chemistry.

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Special Chemistry/Endocrinology Donald Walt Chandler, PhD – Discipline Director, Special Chemistry Endocrinology, LabCorp Office location: Calabasas Hills, CA | Office telephone: 818-867-1370 | E-mail address: [email protected] Dr Chandler received his PhD in biochemistry from the University of California, Los Angeles. He has more than 40 years of experience in diagnostic testing of steroid hormones and has been published in numerous professional journals. Dr Chandler is a past recipient of the National Institutes of Health Cell and Molecular Biology National Research Service Award. He is licensed by the state of California as a clinical chemist and certified as a New York State laboratory director. He is a member of the Endocrine Society, the Pediatric Endocrine Society, and the American Association of Clinical Chemistry.

Dr Young is a member of the American Society for Clinical Chemistry.

Specimen Quality Mark Sharp – Discipline Director, Specimen Quality, LabCorp Office location: Elon, NC | Office telephone: 336-436-2327 | E-mail address: [email protected] Mr Sharp has been with LabCorp for more than 30 years. He worked in the routine chemistry lab in Burlington, North Carolina, for 20 years, and for the past 13 years he has worked in Science and Technology. Mr Sharp’s areas of expertise include instrument interfaces, middleware, remote diagnostic systems, instruments used for pipetting, and automation systems.

H. Thomas Spillman, PhD – Discipline Director, Specimen Quality, LabCorp Office location: San Diego, CA | Office telephone: 858-668-3722 | E-mail address: [email protected] Dr Spillman is a diplomate of the American Board of Clinical Chemistry. He earned a PhD in biochemistry from the University of Illinois at Champaign-Urbana. He completed a postdoctoral fellowship in biochemistry at State University of New York at Stony Brook and another in clinical chemistry at University of Texas Medical School at Houston.

Dr Spillman’s expertise from formal training is in clinical chemistry and Roche molecular polymerase chain reaction (PCR) school. He held academic appointments and clinical positions at the University of Texas Medical School Department of Pathology and Laboratory Medicine from 1983-1990, during which time he participated in medical student and resident teaching and the service functions of the department and hospital laboratories. At the Baylor College of Medicine in Houston, Texas, he managed testing in the reproductive endocrine laboratory within the Department of Obstetrics and Gynecology from 1988-1990. Dr Spillman joined LabCorp in 1990 and served as technical director for the San Diego laboratory for 7 years and operations director for 10 years. He also served as co-discipline director for automated chemistry and was a participant on the Endocrine Subcommittee.

Dr Spillman has authored several published articles and abstracts.