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IV Drug Compatibility Chart

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IV Drug Compatibility Chart IV Drug Compatibility Chart The IV drug compatibility chart is based on information from the Handbook of Injectable Drugs, 16th Edition, by Lawrence A. Trissel, FASHP, copyright 2010, American Society of Health-System Pharmacists. Incompatibilities are based on meeting any of the following criteria: • Additive Compatibility • Drugs in Syringe Compatibility • Y-Site Injection Compatibility (1:1 Mixture) Additionally, in some cases one brand of product may be compatible but another brand of drug is not. When this occurred, “incompatible” was used. Disclaimer: This IV Drug Compatibility Chart is provided as a quick reference, however since information is subject to change it is advised that you check with a pharmacist for recommendations as well as product information to check for any changes or additional incompatibilities. Key: • = Compatible • = Incompatible • = A drug intersects with itself • = The relationship was investigated and the results were equivocal. = No data available A • • • • • • • Verapamil Verapamil • Succinylcholine (Anectine) Succinylcholine Succinylcholine (Anectine) Succinylcholine • • • Sodium nitroprusside (Nipride) nitroprusside Sodium Sodium nitroprusside (Nipride) nitroprusside Sodium • • • • • • • • • • Sodium bicarbonate Sodium Sodium bicarbonate Sodium • • • • • • • Propofol (Diprivan) Propofol Propofol (Diprivan) Propofol • • • • • • • • • • • • Potassium chloride Potassium Potassium chloride Potassium • • Phenytoin (Dilantin) Phenytoin Phenytoin (Dilantin) Phenytoin • • • • • • Pantoprazole (Protonix) Pantoprazole Pantoprazole (Protonix) Pantoprazole • • • Norepinephrine Norepinephrine Bitartrate Norepinephrine • • • • • • • • • • • • • • Morphine Sulfate Morphine Morphine Sulfate Morphine • • • • Metoprolol Tartrate (Lopressor) Tartrate Metoprolol Metoprolol Tartrate (Lopressor) Tartrate Metoprolol • • • • • • • • Magnesium Sulfate Magnesium Magnesium Sulfate Magnesium • • • • • • • Lorazepam (Ativan) Lorazepam Lorazepam (Ativan) Lorazepam • • • • • Lidocaine (Xylocaine) Lidocaine Lidocaine (Xylocaine) Lidocaine • • • Insulin (regular) Insulin Insulin (regular) Insulin • • • • • • • Heparin Heparin • • • • • • Furosemide (Lasix) Furosemide Furosemide (Lasix) Furosemide • • • • Esmolol (Brevibloc) Esmolol Esmolol (Brevibloc) Esmolol • • • • Epinephrine (Adrenalin) Epinephrine Epinephrine (Adrenalin) Epinephrine • • • • • • • Dopamine Dopamine • • • • • • • Dobutamine (Dobutrex) Dobutamine Dobutamine (Dobutrex) Dobutamine • • • • Diltiazem (Cardizem) Diltiazem Diltiazem (Cardizem) Diltiazem • • Calcium chloride Calcium Calcium chloride Calcium • • • Atropine Atropine • • • Argatroban Argatroban • • • • Amiodarone (Cordarone) (Cordarone) Amiodarone Amiodarone Alteplase (Activase, rTPA) rTPA) (Activase, (Activase, Alteplase Alteplase n Abatacept Abciximab Amifostine Adenosine Azacitidine Argatroban Aldesleukin Azathioprine Azithromyci Asparaginase Acetylcysteine Atropine Sulfate Amikacin Sulfate Acyclovir Sodium Ampicillin Sodium Allopurinol Sodium Atracurium Besylate Antihemophilic Factor Alteplase, Recombinant Alfentanil hydrochloride Amiodarone Hydrochloride Amphotericin B Lipid-Based Amphotericin B Desoxycholate Ampicillin Sodium/Sulbactam Sodium IV Drug Compatibility Chart Alteplase (Activase, rTPA) Amiodarone (Cordarone) Argatroban Atropine Calcium chloride Diltiazem (Cardizem) Dobutamine (Dobutrex) Dopamine Epinephrine (Adrenalin) Esmolol (Brevibloc) Furosemide (Lasix) Heparin Insulin (regular) Lidocaine (Xylocaine) Lorazepam (Ativan) Magnesium Sulfate Metoprolol Tartrate (Lopressor) Morphine Sulfate Norepinephrine Bitartrate Pantoprazole (Protonix) Phenytoin (Dilantin) Potassium chloride Propofol (Diprivan) Sodium bicarbonate Sodium nitroprusside (Nipride) Succinylcholine (Anectine) Verapamil IV DrugCompatibilityChart Buprenorphine Hydrochloride Bendamustine Hydrochloride Bleomycin Sulfate(BLM) Benztropine Mesylate Butorphanol Tartrate Bevacizumab Basaliximab Bumetanide Bortezomib Bivaliruden Busulfan Alteplase (Activase, rTPA) • Amiodarone (Cordarone) • Argatroban Atropine • • • Calcium chloride Diltiazem (Cardizem) • • Dobutamine (Dobutrex) • • Dopamine • Epinephrine (Adrenalin) • Esmolol (Brevibloc) • Furosemide (Lasix) • • • • Heparin • • Insulin (regular) Lidocaine (Xylocaine) • Lorazepam (Ativan) • • Magnesium Sulfate • Metoprolol Tartrate (Lopressor) • Morphine Sulfate • • Norepinephrine Bitartrate • Pantoprazole (Protonix) Phenytoin (Dilantin) Potassium chloride • Propofol (Diprivan) • • Sodium bicarbonate • Sodium nitroprusside (Nipride) • Succinylcholine (Anectine) Verapamil • A B Digoxin Diazepam Docetaxel Decitabine Doripenem Daclizumab Daptomycin Dacarbazine Dimenhydrinate Dexamethasone Drotrecogin Alfa Darbepoetin Alfa Denileukin Diftitox Doxycycline Hyclate Desmopressin Acetate Diltiazem Hydrochloride Dopamine Hydrochloride Dobutamine Hydrochloride Diphenhydramine Hydrochloride Dexmedetomidine Hydrochloride Daunorubicin Hydrochloride (DNR) Dexamethasone Sodium Phosphate Doxorubicin Hydrochloride, Conventional C • • • • • • • • Verapamil Succinylcholine (Anectine) Succinylcholine • • • Sodium nitroprusside (Nipride) nitroprusside Sodium • • • • • • • • • • • Sodium bicarbonate Sodium • • • • • • • • • • • • • • • • Propofol (Diprivan) Propofol • • • • • • • • Potassium chloride Potassium • • • Phenytoin (Dilantin) Phenytoin • • • • • • • • • Pantoprazole (Protonix) Pantoprazole • • • • • Norepinephrine Bitartrate Norepinephrine • • • • • • • • • • • • Morphine Sulfate Morphine Metoprolol Tartrate (Lopressor) Tartrate Metoprolol • • • • • • • • • • • Magnesium Sulfate Magnesium • • • • • • Lorazepam (Ativan) Lorazepam • • • • • • • Lidocaine (Xylocaine) Lidocaine • • • Insulin (regular) Insulin • • • • • • • • • Heparin • • • • • • • • Furosemide (Lasix) Furosemide • • • • • • Esmolol (Brevibloc) Esmolol • • • • • Epinephrine (Adrenalin) Epinephrine • • • • • • Dopamine • • • • • • Dobutamine (Dobutrex) Dobutamine • • • • • • • • Diltiazem (Cardizem) Diltiazem • • Calcium chloride Calcium • Atropine Argatroban • • • • • • • Amiodarone (Cordarone) Amiodarone Alteplase (Activase, rTPA) (Activase, Alteplase Cisplatin Cidofovir Cimetidine Carmustine Cabazitaxel Carboplatin Ceftazidime Clorfarabine Cyclosporine Ciprofloxacin Cytomegalovirus Cefoxitin Sodium Calcium Chloride Immune Globulin Intravenous, Human Immune Globulin Intravenous, Calcium Gluconate Cefotaxime Sodium C1 Inhibitor, Human C1 Inhibitor, Ceftizoxime Sodium Ceftriaxone Sodium Clevidipine Butyrate Cefturoxime Sodium Cisatracurium Besylate Clindamycin Phosphate Cefepime Hydrochloride Chlorpromazine Hydrochloride Ceftaroline Fosamil Monoacetate Chloramphenicol Sodium Succinate IV Drug Compatibility Chart D • • • • • • Verapamil Succinylcholine (Anectine) Succinylcholine • • • • Sodium nitroprusside (Nipride) nitroprusside Sodium • • • • • • • • • • Sodium bicarbonate Sodium • • • • • • • • • Propofol (Diprivan) Propofol • • • • • • • • • • • • Potassium chloride Potassium • • Phenytoin (Dilantin) Phenytoin • • • • • • • • Pantoprazole (Protonix) Pantoprazole • • • • • • • Norepinephrine Bitartrate Norepinephrine • • • • • • • • • • • Morphine Sulfate Morphine Metoprolol Tartrate (Lopressor) Tartrate Metoprolol • • • • • • • Magnesium Sulfate Magnesium • • • • • • • • Lorazepam (Ativan) Lorazepam • • • • • • • • Lidocaine (Xylocaine) Lidocaine • • • • • • Insulin (regular) Insulin • • • • • • Heparin • • • • • • • • • • • • Furosemide (Lasix) Furosemide • • • • Esmolol (Brevibloc) Esmolol • • • Epinephrine (Adrenalin) Epinephrine • • • • • • • • • Dopamine • • • • • • • • • • • Dobutamine (Dobutrex) Dobutamine • • • • • • • • Diltiazem (Cardizem) Diltiazem • • Calcium chloride Calcium • • • • Atropine • • • • Argatroban • • • • • Amiodarone (Cordarone) Amiodarone • • Alteplase (Activase, rTPA) (Activase, Alteplase Digoxin Diazepam Docetaxel Decitabine Doripenem Daclizumab Daptomycin Dacarbazine Dimenhydrinate Dexamethasone Drotrecogin Alfa Darbepoetin Alfa Denileukin Diftitox Doxycycline Hyclate Desmopressin Acetate Diltiazem Hydrochloride Dopamine Hydrochloride Dobutamine Hydrochloride Diphenhydramine Hydrochloride Dexmedetomidine Hydrochloride Daunorubicin Hydrochloride (DNR) Dexamethasone Sodium Phosphate Doxorubicin Hydrochloride, Conventional IV Drug Compatibility Chart Verapamil Succinylcholine (Anectine) Succinylcholine Sodium nitroprusside (Nipride) nitroprusside Sodium Sodium bicarbonate Sodium Propofol (Diprivan) Propofol Potassium chloride Potassium Phenytoin (Dilantin) Phenytoin Pantoprazole (Protonix) Pantoprazole Norepinephrine Bitartrate Norepinephrine Morphine Sulfate Morphine Metoprolol Tartrate (Lopressor) Tartrate Metoprolol Magnesium Sulfate Magnesium Lorazepam (Ativan) Lorazepam Lidocaine (Xylocaine) Lidocaine Insulin (regular) Insulin Heparin Furosemide (Lasix) Furosemide Esmolol (Brevibloc) Esmolol Epinephrine (Adrenalin) Epinephrine Dopamine Dobutamine (Dobutrex) Dobutamine Diltiazem (Cardizem) Diltiazem Calcium chloride Calcium Atropine Argatroban Amiodarone (Cordarone) Amiodarone Alteplase (Activase, rTPA) (Activase, Alteplase E • • Verapamil Succinylcholine (Anectine) Succinylcholine • • • Sodium nitroprusside (Nipride) nitroprusside Sodium • • • • Sodium bicarbonate Sodium • • • Propofol (Diprivan) Propofol • • • • • • • Potassium chloride Potassium • • Phenytoin (Dilantin) Phenytoin • • • • Pantoprazole (Protonix) Pantoprazole • • Norepinephrine Bitartrate Norepinephrine • • • • • Morphine Sulfate Morphine Metoprolol Tartrate (Lopressor) Tartrate Metoprolol • • • • Magnesium Sulfate Magnesium
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