FCM Global Newsletter #51 Nov 2018
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Anti-Cholinergic Alkaloids As Potential Therapeutic Agents for Alzheimer's Disease
Indian Journal of Biochemistry & Biophysics Vol. 50, April 2013, pp. 120-125 Anti-cholinergic alkaloids as potential therapeutic agents for Alzheimer’s disease: An in silico approach Huma Naaz, Swati Singh, Veda P Pandey, Priyanka Singh and Upendra N Dwivedi* Bioinformatics Infrastructure Facility, Center of Excellence in Bioinformatics, Department of Biochemistry, University of Lucknow, Lucknow 226 007, India Received 10 September 2012; revised 25 January 2013 Alzheimer’s disease (AD), a progressive neurodegenerative disorder with many cognitive and neuropsychiatric symptoms is biochemically characterized by a significant decrease in the brain neurotransmitter acetylcholine (ACh). Plant-derived metabolites, including alkaloids have been reported to possess neuroprotective properties and are considered to be safe, thus have potential for developing effective therapeutic molecules for neurological disorders, such as AD. Therefore, in the present study, thirteen plant-derived alkaloids, namely pleiocarpine, kopsinine, pleiocarpamine (from Pleiocarpa mutica, family: Annonaceae), oliveroline, noroliveroline, liridonine, isooncodine, polyfothine, darienine (from Polyalthia longifolia, family: Apocynaceae) and eburnamine, eburnamonine, eburnamenine and geissoschizol (from Hunteria zeylanica, family: Apocynaceae) were analyzed for their anti-cholinergic action through docking with acetylcholinesterase (AChE) as target. Among the alkaloids, pleiocarpine showed promising anti-cholinergic potential, while its amino derivative showed about six-fold -
5994392 Tion of Application No. 67375.734 Eb3-1685, PEN. T
USOO5994392A United States Patent (19) 11 Patent Number: 5,994,392 Shashoua (45) Date of Patent: Nov.30, 1999 54 ANTIPSYCHOTIC PRODRUGS COMPRISING 5,120,760 6/1992 Horrobin ................................. 514/458 AN ANTIPSYCHOTICAGENT COUPLED TO 5,141,958 8/1992 Crozier-Willi et al. ................ 514/558 AN UNSATURATED FATTY ACID 5,216,023 6/1993 Literati et al. .......................... 514/538 5,246,726 9/1993 Horrobin et al. ....................... 424/646 5,516,800 5/1996 Horrobin et al. ....................... 514/560 75 Inventor: Victor E. Shashoua, Brookline, Mass. 5,580,556 12/1996 Horrobin ................................ 424/85.4 73 Assignee: Neuromedica, Inc., Conshohocken, Pa. FOREIGN PATENT DOCUMENTS 30009 6/1981 European Pat. Off.. 21 Appl. No.: 08/462,820 009 1694 10/1983 European Pat. Off.. 22 Filed: Jun. 5, 1995 09 1694 10/1983 European Pat. Off.. 91694 10/1983 European Pat. Off.. Related U.S. Application Data 59-025327 2/1984 Japan. 1153629 6/1989 Japan. 63 Continuation of application No. 08/080,675, Jun. 21, 1993, 1203331 8/1989 Japan. abandoned, which is a continuation of application No. 07/952,191, Sep. 28, 1992, abandoned, which is a continu- (List continued on next page.) ation of application No. 07/577,329, Sep. 4, 1990, aban doned, which is a continuation-in-part of application No. OTHER PUBLICATIONS 07/535,812,tion of application Jun. 11, No. 1990, 67,375.734 abandoned, Eb3-1685, which is a continu-PEN. T. Higuchi et al. 66 Prodrugs as Noye Drug Delivery Sys 4,933,324, which is a continuation-in-part of application No. -
Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Botany and Ecology DIPLOMA TH
Charles University in Prague, Faculty of Pharmacy In Hradec Kralove Department of Pharmaceutical Botany and Ecology ______________________________________________________________________ DIPLOMA THESIS Biological Activity of Plant Metabolites XVII. Alkaloids of Corydalis yanhusuo W.T. Wang Supervisor of Diploma Work: Assoc. Prof. RNDr. Lubomir Opletal, CSc. Head of Department: Prof. RNDr. Luděk Jahodář, CSc. Hradec Králové April, 2011 Gabriella Cipra Declaration I declare that this thesis is my original copyrighted work. All literature and other sources from which I extracted my research in the process are listed in the bibliography and all work is properly cited. This work has not been used to gain another or same title. Acknowledgements I wish to express my deepest gratitude, first and foremost to Assoc. Prof. RNDr. Lubomír Opletal, CSc. for all his guidance, support and enthusiasm with the preparation of this thesis. I would also like to thank the Department of Pharmaceutical Botany and Ecology for the pleasant working environment, as well as Assoc. Prof. PharmDr. Jiří Kuneš, Ph.D. for preparation and interpretation of NMR spectra, Ing. Kateřina Macáková for biological activity measurements, and Ing. Lucie Cahlíková, Ph.D. for MS spectra measurements and interpretations. This work was financially supported by Specific University Research Foundation No SVV-2011-263002 (Study of biologically active compounds in prespective of their prevention and treatment in civil diseases) Table of Contents 1 INTRODUCTION 7 2 AIM OF WORK 10 3 THEORETICAL -
Harvest Bristol Delivery Pricelist Printed On:
Harvest Bristol Delivery Pricelist Printed on: ############# Prices are correct at time of printing but can change without notification Price per unit or Kilo if Bulk BABY & CHILD 60791 BABY NEUTRAL HAIR BODY SHAMPOO - LAVERA £8.99 60794 BABY NEUTRAL NAPPY CREAM - LAVERA £8.45 T059P BABY WIPES ORGANIC COTTON - NATRACARE £3.95 HS880781 BEDTIME BUBBLE BATH MILD-ORG- MUMMA LOVE £4.99 X613P BUBBLE BATH (ORG) - BEAMING BABY £6.45 WEL088 CALENDULA NAPPY CREAM £7.20 G45113 COTTON PATCHES FOR KIDS -ORG- ORGANII £3.95 X640P DEGRADABLE NAPPY SACKS - BEAMING BABY £2.99 X379P JUNIOR NAPPIES - BEAMING BABY £13.99 X377P MAXI NAPPIES - BEAMING BABY £12.99 X378P MAXI PLUS NAPPIES - BEAMING BABY £14.45 X376P MIDI NAPPIES - BEAMING BABY £12.99 X375P MINI NAPPIES - BEAMING BABY £5.98 ENV030 TOOTHBRUSH ENVIRONMENTAL CHILD £2.99 KVV030 VITAL VITS KIDS MULTI 30S HIGHER NATURE £8.39 BODY PRODUCTS T665P 1N BLACK - HERBATINT £9.45 T666P 2N BROWN - HERBATINT £9.49 T727P 3N DARK CHESTNUT - HERBATINT £9.49 T670P 4N CHESTNUT- HERBATINT £9.49 T675P 5N LIGHT CHESTNUT HERBATINT £9.50 T677P 6D DARK GOLDEN BLONDE- HERBATINT £8.85 T678P 6N DARK BLONDE - HERBATINT £10.08 T679P 7D GOLDEN BLONDE HAIR DYE- HERBATINT £9.49 T684P 8N LIGHT BLONDE- HERBATINT £8.85 G11103 AFTER SUN CREAM 50ML -ORG- ORGANII £3.50 T150P ALMOND SOAP (ROUND) - RAMPAL LATOU £3.85 WEL144 ALMOND SOOTHING FACIAL LOTION - WELEDA £17.95 GP414 ALOE CALENDULA AFTER SUN - GREEN PEOPLE £15.95 G11081 ALOE EUCALYPTUS MOUTHWASH-ORG- ORGANII £5.59 URT630 ALOE VERA BODY LOTION -ORG- URTEKRAM £6.99 T671P ALOE VERA -
THC) Contamination? [Version 2; Peer Review: 2 Approved, 1 Approved with Reservations]
F1000Research 2020, 8:1394 Last updated: 02 SEP 2021 BRIEF REPORT Are side effects of cannabidiol (CBD) products caused by tetrahydrocannabinol (THC) contamination? [version 2; peer review: 2 approved, 1 approved with reservations] Dirk W. Lachenmeier , Stephanie Habel, Berit Fischer, Frauke Herbi, Yvonne Zerbe, Verena Bock, Tabata Rajcic de Rezende, Stephan G. Walch , Constanze Sproll Chemisches und Veterinäruntersuchungsamt (CVUA) Karlsruhe, Karlsruhe, 76189, Germany v2 First published: 08 Aug 2019, 8:1394 Open Peer Review https://doi.org/10.12688/f1000research.19931.1 Second version: 11 Feb 2020, 8:1394 https://doi.org/10.12688/f1000research.19931.2 Reviewer Status Third version: 19 Aug 2020, 8:1394 https://doi.org/10.12688/f1000research.19931.3 Invited Reviewers Latest published: 30 Jul 2021, 8:1394 https://doi.org/10.12688/f1000research.19931.4 1 2 3 version 4 Abstract (revision) Cannabidiol (CBD)-containing products are widely marketed as over 30 Jul 2021 the counter products, mostly as food supplements, to avoid the strict rules of medicinal products. Side-effects reported in anecdotal version 3 consumer reports or during clinical studies were first assumed to be (revision) 9 report due to hydrolytic conversion of CBD to psychotropic Δ - 19 Aug 2020 tetrahydrocannabinol (THC) in the stomach after oral consumption. However, research of pure CBD solutions stored in simulated gastric version 2 juice or subjected to various storage conditions such as heat and light (revision) report report with specific liquid chromatographic/tandem mass spectrometric 11 Feb 2020 (LC/MS/MS) and ultra-high pressure liquid chromatographic/quadrupole time-of-flight mass spectrometric version 1 (UPLC-QTOF) analyses was unable to confirm THC formation. -
Analysis of L-Dopa Induced Dyskinesias in 51 Patients with Parkinsonism
J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.34.6.668 on 1 December 1971. Downloaded from J. Neurol. Neurosurg. Psychiat., 1971, 34, 668-673 Analysis of L-dopa induced dyskinesias in 51 patients with Parkinsonism R. J. MONES, T. S. ELIZAN, AND G. J. SIEGEL From the Department of Neurology, Mount Sinai Medical School, New York, New York, U.S.A. SUMMARY An analysis of 51 patients with Parkinsonism who have developed L-dopa induced dyskinesias is presented. The cause has not been proven, although various hypotheses are discussed. One third of the total number of patients treated developed dyskinesia. These patients tend to re- spond better to L-dopa than the other group. There is a tendency for the older patient or the patient with long-standing disease to develop dyskinesias. There appears to be no way of predicting which patients will develop dyskinesia by analysis of the symptoms or the aetiology of the Parkinsonism syndrome. The unilateral characteristic of the dyskinesia in patients with hemi-Parkinsonism and patients with unilateral thalamotomies suggests that structural abnormalities are critical in deter-guest. Protected by copyright. mining the presence and localization of dyskinesias. This is supported by non-occurrence of similarly treated patients without Parkinsonism. L-dopa is now established as the treatment of choice and 45 started in the hospital. The protocol for the medical for Parkinsonism. Many articles have appeared in and neurological evaluation of these patients, the follow- the literature since the initial work of Cotzias, up care, and the laboratory data are included in a pre- Van vious paper (Mones, 1969). -
Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Sedative
Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Sedative Chemical Dosage (+)-BORNYL-ISOVALERATE -- (-)-DICENTRINE LD50=187 1,8-CINEOLE -- 2-METHYLBUT-3-ENE-2-OL -- 6-GINGEROL -- 6-SHOGAOL -- ACYLSPINOSIN -- ADENOSINE -- AKUAMMIDINE -- ALPHA-PINENE -- ALPHA-TERPINEOL -- AMYL-BUTYRATE -- AMYLASE -- ANEMONIN -- ANGELIC-ACID -- ANGELICIN ED=20-80 ANISATIN 0.03 mg/kg ANNOMONTINE -- APIGENIN 30-100 mg/kg ARECOLINE 1 mg/kg ASARONE -- ASCARIDOLE -- ATHEROSPERMINE -- BAICALIN -- BALDRINAL -- BENZALDEHYDE -- BENZYL-ALCOHOL -- Chemical Dosage BERBERASTINE -- BERBERINE -- BERGENIN -- BETA-AMYRIN-PALMITATE -- BETA-EUDESMOL -- BETA-PHENYLETHANOL -- BETA-RESERCYCLIC-ACID -- BORNEOL -- BORNYL-ACETATE -- BOSWELLIC-ACID 20-55 mg/kg ipr rat BRAHMINOSIDE -- BRAHMOSIDE -- BULBOCAPNINE -- BUTYL-PHTHALIDE -- CAFFEIC-ACID 500 mg CANNABIDIOLIC-ACID -- CANNABINOL ED=200 CARPACIN -- CARVONE -- CARYOPHYLLENE -- CHELIDONINE -- CHIKUSETSUSAPONIN -- CINNAMALDEHYDE -- CITRAL ED 1-32 mg/kg CITRAL 1 mg/kg CITRONELLAL ED=1 mg/kg CITRONELLOL -- 2 Chemical Dosage CODEINE -- COLUBRIN -- COLUBRINOSIDE -- CORYDINE -- CORYNANTHEINE -- COUMARIN -- CRYOGENINE -- CRYPTOCARYALACTONE 250 mg/kg CUMINALDEHYDE -- CUSSONOSIDE-A -- CYCLOSTACHINE-A -- DAIGREMONTIANIN -- DELTA-9-THC 10 mg/orl/man/day DESERPIDINE -- DESMETHOXYANGONIN 200 mg/kg ipr DIAZEPAM 40-200 ug/lg/3-4x/day DICENTRINE LD50=187 DIDROVALTRATUM -- DIHYDROKAWAIN -- DIHYDROMETHYSTICIN 60 mg/kg ipr DIHYDROVALTRATE -- DILLAPIOL ED50=1.57 DIMETHOXYALLYLBENZENE -- DIMETHYLVINYLCARBINOL -- DIPENTENE -
THC) Contamination? [Version 3; Peer Review: 2 Approved, 1 Approved with Reservations]
F1000Research 2020, 8:1394 Last updated: 27 MAY 2021 BRIEF REPORT Are side effects of cannabidiol (CBD) products caused by tetrahydrocannabinol (THC) contamination? [version 3; peer review: 2 approved, 1 approved with reservations] Dirk W. Lachenmeier , Stephanie Habel, Berit Fischer, Frauke Herbi, Yvonne Zerbe, Verena Bock, Tabata Rajcic de Rezende, Stephan G. Walch, Constanze Sproll Chemisches und Veterinäruntersuchungsamt (CVUA) Karlsruhe, Karlsruhe, 76187, Germany v3 First published: 08 Aug 2019, 8:1394 Open Peer Review https://doi.org/10.12688/f1000research.19931.1 Second version: 11 Feb 2020, 8:1394 https://doi.org/10.12688/f1000research.19931.2 Reviewer Status Latest published: 19 Aug 2020, 8:1394 https://doi.org/10.12688/f1000research.19931.3 Invited Reviewers 1 2 3 Abstract Cannabidiol (CBD)-containing products are widely marketed as over version 3 the counter products, mostly as food supplements, to avoid the strict (revision) report rules of medicinal products. Side-effects reported in anecdotal 19 Aug 2020 consumer reports or during clinical studies were first assumed to be due to hydrolytic conversion of CBD to psychotropic Δ9- version 2 9 tetrahydrocannabinol (Δ -THC) in the stomach after oral consumption. (revision) report report However, research of pure CBD solutions stored in simulated gastric 11 Feb 2020 juice or subjected to various storage conditions such as heat and light with specific liquid chromatographic/tandem mass spectrometric version 1 (LC/MS/MS) and ultra-high pressure liquid 08 Aug 2019 report report chromatographic/quadrupole time-of-flight mass spectrometric (UPLC-QTOF) analyses was unable to confirm THC formation. Another hypothesis for the side-effects of CBD products may be residual Δ9- 1. -
2016 What’S Hot 2016
OCTOBER 4-8 R Expo Hall October 6 & 7 2016 WHAT’S HOT 2016 THE WORLD'S LEADING INGREDIENT AND SOLUTIONS TRADESHOW WHERE SCIENCE & STRATEGY INTERSECT. WHAT’S HOT at SupplySide West TABLE OF CONTENTS A SPECIAL ALL-DIGITAL ISSUE October 2016 3 VIEWPOINT 4 AGENDA-AT-A-GLANCE 8 WHAT’S NEW IN CONTENT 9 SPORTS NUTRITION 10 SUPPLEMENTS & BEAUTY TABLE OF CONTENTS TABLE 11 LEGAL 12 FOOD & BEVERAGE 13 TARGETED CONTENT OPPORTUNITIES 16 SUPPLYSIDE CENTRAL 17 EDITOR’S CHOICE AWARDS 19 SURVIVAL KIT 20 FIRST-TIME ATTENDEE RECEPTION 22 EXHIBITOR NEWS 31 SUPPLYSIDE & VITAFOODS GLOBAL STOREFRONTS 32 HOT PRODUCTS Copyright © 2016 Informa Exhibitions LLC. All rights reserved. The publisher reserves the right to accept or reject any advertising or editorial material. Advertisers, and/or their agents, assume the responsibility for all content of published advertisements and assume responsibility for any claims against the publisher based on the advertisement. Editorial contributors assume responsibility for their published works and assume responsibility for any claims against the publisher based on the published work. Editorial content may not necessarily reflect the views of the publisher. Materials contained on this site may not be reproduced, modified, distributed, republished or hosted (either directly or by linking) without our prior written permission. You may not alter or remove any trademark, copyright or other notice from copies of content. You may, however, download material from the site (one machine readable copy and one print copy per page) for your personal, noncommercial use only. We reserve all rights in and title to all material downloaded. All items submitted to SUPPLYSIDE become the sole property of Informa Exhibitions LLC. -
Diversity of the Mountain Flora of Central Asia with Emphasis on Alkaloid-Producing Plants
diversity Review Diversity of the Mountain Flora of Central Asia with Emphasis on Alkaloid-Producing Plants Karimjan Tayjanov 1, Nilufar Z. Mamadalieva 1,* and Michael Wink 2 1 Institute of the Chemistry of Plant Substances, Academy of Sciences, Mirzo Ulugbek str. 77, 100170 Tashkent, Uzbekistan; [email protected] 2 Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany; [email protected] * Correspondence: [email protected]; Tel.: +9-987-126-25913 Academic Editor: Ipek Kurtboke Received: 22 November 2016; Accepted: 13 February 2017; Published: 17 February 2017 Abstract: The mountains of Central Asia with 70 large and small mountain ranges represent species-rich plant biodiversity hotspots. Major mountains include Saur, Tarbagatai, Dzungarian Alatau, Tien Shan, Pamir-Alai and Kopet Dag. Because a range of altitudinal belts exists, the region is characterized by high biological diversity at ecosystem, species and population levels. In addition, the contact between Asian and Mediterranean flora in Central Asia has created unique plant communities. More than 8100 plant species have been recorded for the territory of Central Asia; about 5000–6000 of them grow in the mountains. The aim of this review is to summarize all the available data from 1930 to date on alkaloid-containing plants of the Central Asian mountains. In Saur 301 of a total of 661 species, in Tarbagatai 487 out of 1195, in Dzungarian Alatau 699 out of 1080, in Tien Shan 1177 out of 3251, in Pamir-Alai 1165 out of 3422 and in Kopet Dag 438 out of 1942 species produce alkaloids. The review also tabulates the individual alkaloids which were detected in the plants from the Central Asian mountains. -
Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Dry Mouth / Xerostomia
Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Dry Mouth / Xerostomia Chemical Activity Count (+)-CATECHIN 2 (+)-EPIPINORESINOL 1 (-)-ANABASINE 1 (-)-EPICATECHIN 2 (-)-EPIGALLOCATECHIN 2 (-)-EPIGALLOCATECHIN-GALLATE 2 (Z)-1,3-BIS(4-HYDROXYPHENYL)-1,4-PENTADIENE 1 1,8-CINEOLE 2 10-METHOXYCAMPTOTHECIN 1 16-HYDROXY-4,4,10,13-TETRAMETHYL-17-(4-METHYL-PENTYL)-HEXADECAHYDRO- 1 CYCLOPENTA[A]PHENANTHREN-3-ONE 2,3-DIHYDROXYBENZOIC-ACID 1 3'-O-METHYL-CATECHIN 1 3-ACETYLACONITINE 1 3-O-METHYL-(+)-CATECHIN 1 4-O-METHYL-GLUCURONOXYLAN 1 5,7-DIHYDROXY-2-METHYLCHROMONE-8-C-BETA-GLUCOPYRANOSIDE 1 5-HYDROXYTRYPTAMINE 1 5-HYDROXYTRYPTOPHAN 1 6-METHOXY-BENZOLINONE 1 ACEMANNAN 1 ACETYL-CHOLINE 1 ACONITINE 2 ADENOSINE 2 AFFINISINE 1 AGRIMONIIN 1 ALANTOLACTONE 2 ALKANNIN 1 Chemical Activity Count ALLANTOIN 1 ALLICIN 2 ALLIIN 2 ALLOISOPTEROPODINE 1 ALLOPTEROPODINE 1 ALLOPURINOL 1 ALPHA-LINOLENIC-ACID 1 ALPHA-TERPINEOL 1 ALPHA-TOCOPHEROL 2 AMAROGENTIN 1 AMELLIN 1 ANABASINE 1 ANDROMEDOTOXIN 1 ANETHOLE 1 ANTHOCYANIDINS 1 ANTHOCYANINS 1 ANTHOCYANOSIDE 1 APIGENIN 1 APOMORPHINE 1 ARABINO-3,6-GALACTAN-PROTEIN 1 ARABINOGALACTAN 1 ARACHIDONIC-ACID 1 ARCTIGENIN 2 ARECOLINE 1 ARGLABRIN 1 ARISTOLOCHIC-ACID 1 ARISTOLOCHIC-ACID-I 1 2 Chemical Activity Count ARMILLARIEN-A 1 ARTEMISININ 1 ASCORBIC-ACID 4 ASTRAGALAN-I 1 ASTRAGALAN-II 1 ASTRAGALAN-III 1 ASTRAGALIN 1 AURICULOSIDE 1 BAICALEIN 1 BAICALIN 1 BAKUCHIOL 1 BENZALDEHYDE 1 BERBAMINE 1 BERBERASTINE 3 BERBERINE 3 BERBERINE-CHLORIDE 1 BERBERINE-IODIDE 1 BERBERINE-SULFATE 1 BETA-AMYRIN-PALMITATE -
MY EVERYDAY HEALTH FEEL FIT FEEL Good USE SANA HEMP JUICE a SOURCE of WELLBEING 1 Content Green Juice Benefits
MY EVERYDAY HEALTH FEEL FIT FEEL Good USE SANA HEMP JUICE A SOURCE OF WELLBEING 1 Content Green Juice Benefits Initially, the juicing market was supported mostly by people doing liquid-only cleanses, marketed as a way to rid the body of toxins and bloat. Now, more consumers are drinking juice as a meal Green Juice Benefits replacement, a quick infusion of juice to imbue the body with a ‘health boost’. Sana Hemp Juice – the Green Juice with something extra There has recently been a marked drop-off in popularity of fruit juices due to the increased realization that fruit juices usually come with a very heavy load of sugars. This has now led to the A Brief History of Hemp increasing popularity of vegetable juices and the upsurge in ‘Green Juices’. Hemp versus Marijuana Best of Hemp – Pure, Fresh, Cold-Pressed, Frozen, & Raw Vegetable juices have many additional beneficial nutrients, although some fruit ingredients are still included to make the vegetable juices more palatable. Healthy Constituents of Initially, home production of juices was the most popular approach, however, the time and effort Sana Hemp Juice Sana Hemp Juice – the Green needed to handle the relatively large volumes of vegetables, and fruits, has become a significant Vitamins & Minerals Juice with something extra negative to handling juicing as a DIY (Do It Yourself) process. Omega Fatty Acids Cannabidiol In many ways, Sana Hemp Juice is the ultimate Consequently, there is an increasing industry building up for ready-made juices. Although these Green Juice: ready-made juices appear to be a relatively high price, once the actual costs of self-preparation Not only does Sana Hemp Juice have a wide are taken into account, there is virtually no price difference – yet the convenience of ready-made What is Cannabidiol? range of vitamins, minerals, and enzymes, it juices is extremely significant.