DOCSLIB.ORG

Supplemental Information

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Supplemental Information ARTICLE Supplemental Information PEDIATRICS Volume 146, Number 2, August 2020 1 SUPPLEMENTAL TABLE 4 ICD-10 Codes Used for Pneumonia and Sinusitis in the Study ICD-10 Code ICD-10 Code Description CCS Category Pneumonia A3781 Whooping cough due to other Bordetella species with pneumonia 3 A3791 Whooping cough, unspecified species with pneumonia 3 A5484 Gonococcal pneumonia 9 A5004 Early congenital syphilitic pneumonia 9 A0103 Typhoid pneumonia 122 A0222 Salmonella pneumonia 122 A202 Pneumonic plague 122 A3701 Whooping cough due to Bordetella pertussis with pneumonia 122 A3711 Whooping cough due to Bordetella parapertussis with pneumonia 122 A430 Pulmonary nocardiosis 122 A481 Legionnaires disease 122 B012 Varicella pneumonia 122 B052 Measles complicated by pneumonia 122 B0681 Rubella pneumonia 122 B250 Cytomegaloviral pneumonitis 122 B371 Pulmonary candidiasis 122 B380 Acute pulmonary coccidioidomycosis 122 B381 Chronic pulmonary coccidioidomycosis 122 B382 Pulmonary coccidioidomycosis, unspecified 122 B390 Acute pulmonary histoplasmosis capsulati 122 B391 Chronic pulmonary histoplasmosis capsulati 122 B392 Pulmonary histoplasmosis capsulati, unspecified 122 B583 Pulmonary toxoplasmosis 122 B59 Pneumocystosis 122 B7781 Ascariasis pneumonia 122 J120 Adenoviral pneumonia 122 J121 Respiratory syncytial virus pneumonia 122 J122 Parainfluenza virus pneumonia 122 J123 Human metapneumovirus pneumonia 122 J1281 Pneumonia due to SARS-associated coronavirus 122 J1289 Other viral pneumonia 122 J129 Viral pneumonia, unspecified 122 J13 Pneumonia due to Streptococcus pneumoniae 122 J14 Pneumonia due to Hemophilus influenzae 122 J150 Pneumonia due to Klebsiella pneumoniae 122 J151 Pneumonia due to Pseudomonas 122 J1520 Pneumonia due to Staphylococcus, unspecified 122 J15211 Pneumonia due to methicillin-susceptible Staphylococcus 122 J15212 Pneumonia due to methicillin-resistant Staphylococcus aureus 122 J1529 Pneumonia due to other Staphylococcus 122 J153 Pneumonia due to Streptococcus, group B 122 J154 Pneumonia due to other streptococci 122 J155 Pneumonia due to Escherichia coli 122 J156 Pneumonia due to other aerobic Gram-negative bacteria 122 J157 Pneumonia due to Mycoplasma pneumoniae 122 J158 Pneumonia due to other specified bacteria 122 J159 Unspecified bacterial pneumonia 122 J160 Chlamydial pneumonia 122 J168 Pneumonia due to other specified infectious organisms 122 J17 Pneumonia in diseases classified elsewhere 122 J180 Bronchopneumonia, unspecified organism 122 J181 Lobar pneumonia, unspecified organism 122 J188 Other pneumonia, unspecified organism 122 J189 Pneumonia, unspecified organism 122 J851 Abscess of lung with pneumonia 122 J09X1 Influenza due to identified novel influenza A virus with pneumonia 123 J1000 Flu due to other identified influenza virus with unspecified type of pneumonia 123 J1001 Flu due to other identified influenza virus with the same other identified 123 influenza virus pneumonia 2 ARTICLE SUPPLEMENTAL TABLE 4 Continued ICD-10 Code ICD-10 Code Description CCS Category J1008 Influenza due to other identified influenza virus with other pneumonia 123 J1100 Flu due to unidentified influenza virus with unspecified type of pneumonia 123 J1108 Flu due to unidentified influenza virus with specified pneumonia 123 J182 Hypostatic pneumonia, unspecified organism 133 J84111 Idiopathic interstitial pneumonia, not otherwise specified 133 J84116 Cryptogenic organizing pneumonia 133 J84117 Desquamative interstitial pneumonia 133 J842 Lymphoid interstitial pneumonia 133 Z8701 Personal history of pneumonia (recurrent) 133 P230 Congenital pneumonia due to viral agent 224 P231 Congenital pneumonia due to Chlamydia 224 P232 Congenital pneumonia due to Staphylococcus 224 P233 Congenital pneumonia due to Streptococcus, group B 224 P234 Congenital pneumonia due to E. coli 224 P235 Congenital pneumonia due to Pseudomonas 224 P236 Congenital pneumonia due to other bacterial agents 224 P238 Congenital pneumonia due to other organisms 224 P239 Congenital pneumonia, unspecified 224 J95851 Ventilator-associated pneumonia 238 Sinusitis J0140 Acute pansinusitis, unspecified 126 J0141 Acute recurrent pansinusitis 126 J0180 Other acute sinusitis 126 J0181 Other acute recurrent sinusitis 126 J0190 Acute sinusitis, unspecified 126 J0191 Acute recurrent sinusitis, unspecified 126 J069 Acute upper respiratory infection, unspecified 126 J320 Chronic maxillary sinusitis 126 J321 Chronic frontal sinusitis 126 J322 Chronic ethmoidal sinusitis 126 J323 Chronic sphenoidal sinusitis 126 J324 Chronic pansinusitis 126 J328 Other chronic sinusitis 126 J329 Chronic sinusitis, unspecified 126 SARS, severe acute respiratory syndrome. PEDIATRICS Volume 146, Number 2, August 2020 3 SUPPLEMENTAL TABLE 5 ICD-10 Codes for Acute Diagnoses With Potentially Appropriate Indications for Steroids ICD-10 Code ICD-10 Code Description CCS Category J050 Acute obstructive laryngitis (croup) 126 R062 Wheezing 133 T486X6A Underdosing of antiasthmatics, initial encounter 244 T486X6D Underdosing of antiasthmatics, subsequent encounter 244 T486X6S Underdosing of antiasthmatics, sequela 244 J4520 Mild intermittent asthma, uncomplicated 128 J4521 Mild intermittent asthma with (acute) exacerbation 128 J4522 Mild intermittent asthma with status asthmaticus 128 J4530 Mild persistent asthma, uncomplicated 128 J4531 Mild persistent asthma with (acute) exacerbation 128 J4532 Mild persistent asthma with status asthmaticus 128 J4540 Moderate persistent asthma, uncomplicated 128 J4541 Moderate persistent asthma with (acute) exacerbation 128 J4542 Moderate persistent asthma with status asthmaticus 128 J4550 Severe persistent asthma, uncomplicated 128 J4551 Severe persistent asthma with (acute) exacerbation 128 J4552 Severe persistent asthma with status asthmaticus 128 J45901 Unspecified asthma with (acute) exacerbation 128 J45902 Unspecified asthma with status asthmaticus 128 J45909 Unspecified asthma, uncomplicated 128 J45990 Exercise-induced bronchospasm 128 J45991 Cough-variant asthma 128 J45998 Other asthma 128 B4481 Allergic bronchopulmonary aspergillosis 253 J305 Allergic rhinitis due to food 253 K522 Allergic and dietetic gastroenteritis and colitis 253 K5221 Food protein–induced enterocolitis syndrome 253 K5222 Food protein–induced enteropathy 253 K5229 Other allergic and dietetic gastroenteritis and colitis 253 K9041 Nonceliac gluten sensitivity 253 L200 Besnier prurigo 253 L2081 Atopic neurodermatitis 253 L2082 Flexural eczema 253 L2083 Infantile (acute) (chronic) eczema 253 L2084 Intrinsic (allergic) eczema 253 L2089 Other atopic dermatitis 253 L209 Atopic dermatitis, unspecified 253 L22 Diaper dermatitis 253 L230 Allergic contact dermatitis due to metals 253 L231 Allergic contact dermatitis due to adhesives 253 L232 Allergic contact dermatitis due to cosmetics 253 L233 Allergic contact dermatitis due to drugs in contact with skin 253 L234 Allergic contact dermatitis due to dyes 253 L235 Allergic contact dermatitis due to other chemical products 253 L236 Allergic contact dermatitis due to food in contact with skin 253 L237 Allergic contact dermatitis due to plants, except food 253 L2381 Allergic contact dermatitis due to animal (cat) (dog) dander 253 L2389 Allergic contact dermatitis due to other agents 253 L239 Allergic contact dermatitis, unspecified cause 253 L240 Irritant contact dermatitis due to detergents 253 L241 Irritant contact dermatitis due to oils and greases 253 L242 Irritant contact dermatitis due to solvents 253 L243 Irritant contact dermatitis due to cosmetics 253 L244 Irritant contact dermatitis due to drugs in contact with skin 253 L245 Irritant contact dermatitis due to other chemical products 253 L246 Irritant contact dermatitis due to food in contact with skin 253 L247 Irritant contact dermatitis due to plants, except food 253 L2481 Irritant contact dermatitis due to metals 253 L2489 Irritant contact dermatitis due to other agents 253 4 ARTICLE SUPPLEMENTAL TABLE 5 Continued ICD-10 Code ICD-10 Code Description CCS Category L249 Irritant contact dermatitis, unspecified cause 253 L250 Unspecified contact dermatitis due to cosmetics 253 L251 Unspecified contact dermatitis due to drugs in contact with skin 253 L252 Unspecified contact dermatitis due to dyes 253 L253 Unspecified contact dermatitis due to other chemical products 253 L254 Unspecified contact dermatitis due to food in contact with skin 253 L255 Unspecified contact dermatitis due to plants, except food 253 L258 Unspecified contact dermatitis due to other agents 253 L259 Unspecified contact dermatitis, unspecified cause 253 L270 Generalized skin eruption due to drugs and medicaments taken internally 253 L271 Localized skin eruption due to drugs and medicaments taken internally 253 L272 Dermatitis due to ingested food 253 L278 Dermatitis due to other substances taken internally 253 L279 Dermatitis due to unspecified substance taken internally 253 L300 Nummular dermatitis 253 L302 Cutaneous autosensitization 253 L308 Other specified dermatitis 253 L309 Dermatitis, unspecified 253 L500 Allergic urticaria 253 L501 Idiopathic urticaria 253 L502 Urticaria due to cold and heat 253 L503 Dermatographic urticaria 253 L504 Vibratory urticaria 253 L505 Cholinergic urticaria 253 L506 Contact urticaria 253 L508 Other urticaria 253 L509 Urticaria, unspecified 253 L560 Drug phototoxic response 253 L561 Drug photoallergic response 253 L562 Photocontact dermatitis (berloque dermatitis) 253 L563 Solar urticaria 253 L564 Polymorphous light eruption 253 L568 Other acute skin changes due to UV radiation 253 L569 Acute skin change due to UV radiation, unspecified 253 L578
Load more

Recommended publications
  • Rhinitis and Sinusitis
    Glendale Animal Hospital 623-934-7243 www.familyvet.com Rhinitis and Sinusitis (Inflammation of the Nose and Sinuses) Basics OVERVIEW Rhinitis—inflammation of the lining of the nose Sinusitis—inflammation of the sinuses The nasal cavity communicates directly with the sinuses; thus inflammation of the nose (rhinitis) and inflammation of the sinuses (sinusitis) often occur together (known as “rhinosinusitis”) “Upper respiratory tract” (also known as the “upper airways”) includes the nose, nasal passages, throat (pharynx), and windpipe (trachea) “Lower respiratory tract” (also known as the “lower airways”) includes the bronchi, bronchioles, and alveoli (the terminal portion of the airways, in which oxygen and carbon dioxide are exchanged) SIGNALMENT/DESCRIPTION OF PET Species Dogs Cats Breed Predilections Short-nosed, flat-faced (known as “brachycephalic”) cats are more prone to long-term (chronic) inflammation of the nose (rhinitis), and possibly fungal rhinitis Dogs with a long head and nose (known as “dolichocephalic dogs,” such as the collie and Afghan hound) are more prone to Aspergillus (a type of fungus) infection and nasal tumors Mean Age and Range Cats—sudden (acute) viral inflammation of the nose and sinuses (rhinosinusitis) and red masses in the nasal cavity and throat (known as “nasopharyngeal polyps”) are more common in young kittens (6–12 weeks of age) Congenital (present at birth) diseases (such as cleft palate) are more common in young pets Tumors/cancer and dental disease—are more common in older pets Foreign
    [Show full text]
  • Laryngitis from Reflux: Prevention for the Performing Singer
    Laryngitis from Reflux: Prevention for the Performing Singer David G. Hanson, MD, FACS Jack J. Jiang, MD, PhD Laryngitis in General Laryngitis is the bane of performers and other professionals who depend on their voice for their art and livelihood. Almost every person has experienced acute laryngitis, usually associated with a viral upper- respiratory infection. Whenever there is inflammation of the vocal fold epithelium, there is an effect on voice quality and strength. Therefore, it is important to understand the factors that can cause laryngitis, especially the preventable causes of laryngitis. Laryngitis is a generic term for inflammation or irritation of the laryngeal tissues. The inflammation can be caused by any kind of injury, including infection, smoking, contact with caustic or acidic substance, allergic reaction, or direct trauma. Inflammatory response of the tissues includes leakage of fluid from blood vessels with edema or swelling, congregation of white blood cells, which release mediators of inflammation, and engorgement of the blood vessels. Most commonly laryngitis occurs from viral infection of the laryngeal epithelial lining associated with a typical cold. The viral infection is almost always quickly conquered by the body's immune system and lasts at most a few days. This kind of acute laryngitis rarely causes any long-term problem unless the vocal folds are damaged by overuse during the illness. Examination of the larynx will show whether the vocal folds are inflamed and allows some prediction of the degree of risk for damage. Other infections of the larynx are fortunately not common but include infections with bacteria and other organisms.
    [Show full text]
  • Rhinotillexomania in a Cystic Fibrosis Patient Resulting in Septal Perforation Mark Gelpi1*, Emily N Ahadizadeh1,2, Brian D’Anzaa1 and Kenneth Rodriguez1
    ISSN: 2572-4193 Gelpi et al. J Otolaryngol Rhinol 2018, 4:036 DOI: 10.23937/2572-4193.1510036 Volume 4 | Issue 1 Journal of Open Access Otolaryngology and Rhinology CASE REPORT Rhinotillexomania in a Cystic Fibrosis Patient Resulting in Septal Perforation Mark Gelpi1*, Emily N Ahadizadeh1,2, Brian D’Anzaa1 and Kenneth Rodriguez1 1 Check for University Hospitals Cleveland Medical Center, USA updates 2Case Western Reserve University School of Medicine, USA *Corresponding author: Mark Gelpi, MD, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA, Tel: (216)-844-8433, Fax: (216)-201-4479, E-mail: [email protected] paranasal sinuses [1,4]. Nasal symptoms in CF patients Abstract occur early, manifesting between 5-14 years of age, and Cystic fibrosis (CF) is a multisystem disease that can have represent a life-long problem in this population [5]. Pa- significant sinonasal manifestations. Viscous secretions are one of several factors in CF that result in chronic sinona- tients with CF can develop thick nasal secretions con- sal pathology, such as sinusitis, polyposis, congestion, and tributing to chronic rhinosinusitis (CRS), nasal conges- obstructive crusting. Persistent discomfort and nasal man- tion, nasal polyposis, headaches, and hyposmia [6-8]. ifestations of this disease significantly affect quality of life. Sinonasal symptoms of CF are managed medically with Digital manipulation and removal of crusting by the patient in an attempt to alleviate the discomfort can have unfore- topical agents and antibiotics, however surgery can be seen damaging consequences. We present one such case warranted due to the chronic and refractory nature of and investigate other cases of septal damage secondary to the symptoms, with 20-25% of CF patients undergoing digital trauma, as well as discuss the importance of sinona- sinus surgery in their lifetime [8].
    [Show full text]
  • Problems in Family Practice
    problems in Family Practice Coughing in Childhood Hyman Sh ran d , M D Cambridge, M assachusetts Coughing in childhood is a common complaint involving a wide spectrum of underlying causes which require a thorough and rational approach by the physician. Most children who cough have relatively simple self-limiting viral infections, but some may have serious disease. A dry environment, allergic factors, cystic fibrosis, and other major illnesses must always be excluded. A simple clinical approach, and the sensible use of appropriate investigations, is most likely to succeed in finding the cause, which can allow precise management. The cough reflex as part of the defense mechanism of the respiratory tract is initiated by mucosal changes, secretions or foreign material in the pharynx, larynx, tracheobronchial Table 1. Persistent Cough — Causes in Childhood* tree, pleura, or ear. Acting as the “watchdog of the lungs,” the “good” cough prevents harmful agents from Common Uncommon Rare entering the respiratory tract; it also helps bring up irritant material from Environmental Overheating with low humidity the airway. The “bad” cough, on the Allergens other hand, serves no useful purpose Pollution Tobacco smoke and, if persistent, causes fatigue, keeps Upper Respiratory Tract the child (and parents) awake, inter­ Recurrent viral URI Pertussis Laryngeal stridor feres with feeding, and induces vomit­ Rhinitis, Pharyngitis Echo 12 Vocal cord palsy Allergic rhinitis Nasal polyp Vascular ring ing. It is best suppressed. Coughs and Prolonged use of nose drops Wax in ear colds constitute almost three quarters Sinusitis of all illness in young children. The Lower Respiratory Tract Asthma Cystic fibrosis Rt.
    [Show full text]
  • SINUSITIS AS a CAUSE of TONSILLITIS. by BEDFORD RUSSELL, F.R.C.S., Surgeon-In-Charge, Throat Departmentt, St
    Postgrad Med J: first published as 10.1136/pgmj.9.89.80 on 1 March 1933. Downloaded from 80 POST-GRADUATE MEDICAL JOURNAL March, 1933 Plastic Surgery: A short course of lecture-demonstrations is being arranged, to be given at the Hammersmith Hospitar, by Sir Harold Gillies, Mr. MacIndoe and Mr. Kilner. Details will be circulated shortly. Technique of Operations: A series of demonstrations is being arranged. Details will be circulated shortly. Demonstrations in (Advanced) Medicine and Surgeryi A series of weekly demonstrations is being arranged. Details will be circulated shortly. A Guide Book, giving details of how to reach the various London Hospitals by tube, tram, or bus, can be obtained from the Fellowship. Price 6d. (Members and Associates, 3d.). SINUSITIS AS A CAUSE OF TONSILLITIS. BY BEDFORD RUSSELL, F.R.C.S., Surgeon-in-Charge, Throat Departmentt, St. Bart's Hospital. ALTHOUGH the existence of sinus-infection has long since been recognized, medical men whose work lies chiefly in the treatment of disease in the nose, throat and ear are frequently struck with the number of cases of sinusitis which have escaped recognition,copyright. even in the presence of symptoms and signs which should have given rise at least to suspicion of such disease. The explanation of the failure to recognize any but the most mlianifest cases of sinusitis lies, 1 think, in the extreme youth of this branch of medicine; for although operations upon the nose were undoubtedly performed thousands of years ago, it was not uintil the adoption of cocaine about forty years ago that it was even to examine the nasal cavities really critically.
    [Show full text]
  • Asthma Exacerbation Management
    CLINICAL PATHWAY ASTHMA EXACERBATION MANAGEMENT TABLE OF CONTENTS Figure 1. Algorithm for Asthma Exacerbation Management – Outpatient Clinic Figure 2. Algorithm for Asthma Management – Emergency Department Figure 3. Algorithm for Asthma Management – Inpatient Figure 4. Progression through the Bronchodilator Weaning Protocol Table 1. Pediatric Asthma Severity (PAS) Score Table 2. Bronchodilator Weaning Protocol Target Population Clinical Management Clinical Assessment Treatment Clinical Care Guidelines for Treatment of Asthma Exacerbations Children’s Hospital Colorado High Risk Asthma Program Table 3. Dosage of Daily Controller Medication for Asthma Control Table 4. Dosage of Medications for Asthma Exacerbations Table 5. Dexamethasone Dosing Guide for Asthma Figure 5. Algorithm for Dexamethasone Dosing – Inpatient Asthma Patient | Caregiver Education Materials Appendix A. Asthma Management – Outpatient Appendix B. Asthma Stepwise Approach (aka STEPs) Appendix C. Asthma Education Handout References Clinical Improvement Team Page 1 of 24 CLINICAL PATHWAY FIGURE 1. ALGORITHM FOR ASTHMA EXACERBATION MANAGEMENT – OUTPATIENT CLINIC Triage RN/MA: • Check HR, RR, temp, pulse ox. Triage level as appropriate • Notify attending physician if patient in severe distress (RR greater than 35, oxygen saturation less than 90%, speaks in single words/trouble breathing at rest) Primary RN: • Give oxygen to keep pulse oximetry greater than 90% Treatment Inclusion Criteria 1. Give nebulized or MDI3 albuterol up to 3 doses. Albuterol dosing is 0.15 to 0.3mg/kg per 2007 • 2 years or older NHLBI guidelines. • Treated for asthma or asthma • Less than 20 kg: 2.5 mg neb x 3 or 2 to 4 puffs MDI albuterol x 3 exacerbation • 20 kg or greater: 5 mg neb x 3 or 4 to 8 puffs MDI albuterol x 3 • First time wheeze with history consistent Note: For moderate (dyspnea interferes with activities)/severe (dyspnea at rest) exacerbations you with asthma can add atrovent to nebulized albuterol at 0.5mg/neb x 3.
    [Show full text]
  • Hoarseness a Guide to Voice Disorders
    MedicineToday PEER REVIEWED ARTICLE POINTS: 2 CPD/1 PDP Hoarseness a guide to voice disorders Hoarseness is usually associated with an upper respiratory tract infection or voice overuse and will resolve spontaneously. In other situations, treatment often requires collaboration between GP, ENT surgeon and speech pathologist. RON BOVA Voice disorders are common and attributable to Inflammatory causes of voice MB BS, MS, FRACS a wide range of structural, medical and behav- dysfunction JOHN McGUINNESS ioural conditions. Dysphonia (hoarseness) refers Acute laryngitis FRCS, FDS RCS to altered voice due to a laryngeal disorder and Acute laryngitis causes hoarseness that can result may be described as raspy, gravelly or breathy. in complete voice loss. The most common cause Dr Bova is an ENT, Head and Intermittent dysphonia is normally always secon - is viral upper respiratory tract infection; other Neck Surgeon and Dr McGuinness dary to a benign disorder, but constant or pro- causes include exposure to tobacco smoke and a is ENT Fellow, St Vincent’s gressive dysphonia should always alert the GP to short period of vocal overuse such as shouting or Hospital, Sydney, NSW. the possibility of malignancy. As a general rule, a singing. The vocal cords become oedematous patient with persistent dysphonia lasting more with engorgement of submucosal blood vessels than three to four weeks warrants referral for (Figure 3). complete otolaryngology assessment. This is par- Treatment is supportive and aims to maximise ticularly pertinent for patients with persisting vocal hygiene (Table), which includes adequate hoarseness who are at high risk for laryngeal can- hydration, a period of voice rest and minimised cer through smoking or excessive alcohol intake, exposure to irritants.
    [Show full text]
  • Parent's Guide to a Sore Throat
    Contact your GP (or call 111) Useful contacts: again Your GP surgery on:....................................... Although in most cases the sore throat (Please insert surgery number here) improves in few days, please contact the GP if any of the following occurs: GP Out of Hours: (After 6.30pm and before 8am). Ring 111 and you can speak to a 1. Your child persistently refuses oral fl uids doctor. If necessary, your child can be seen and has not passed urine for over 18 at one of their centres. Parent’s guide hours. Bristol City Walk-in Centre at Broadmead 2. The fever does not settle within four or to a sore throat Medical Centre located in Boots fi ve days. (Mon-Sat 8am-8pm, Sundays and Bank Holidays 11am-5pm) on: 0117 954 9828 3. Your child develops diffi culty in swallowing despite regular paracetamol South Bristol NHS Community Hospital or ibuprofen. Urgent Care Centre (Every day 8am-8pm) on: 0117 342 9692 4. Your child starts drooling because they Visit www.nhs.uk to fi nd your nearest cannot swallow their saliva. centre. Call 999 If your child is seriously ill, you may be asked to attend the Children’s Hospital If your child develops severe breathing emergency department. diffi culties For further copies of this leafl et, or if you would like it in other formats or languages, please contact 0117 900 2384. Produced in partnership with Bristol Clinical Commissioning Group, North Bristol NHS Trust and University Hospitals Bristol NHS Foundation Trust. End date: June 2016 Your child has been diagnosed with a sore What is the treatment of a sore throat which is very common in children.
    [Show full text]
  • Allergic Bronchopulmonary Aspergillosis: a Perplexing Clinical Entity Ashok Shah,1* Chandramani Panjabi2
    Review Allergy Asthma Immunol Res. 2016 July;8(4):282-297. http://dx.doi.org/10.4168/aair.2016.8.4.282 pISSN 2092-7355 • eISSN 2092-7363 Allergic Bronchopulmonary Aspergillosis: A Perplexing Clinical Entity Ashok Shah,1* Chandramani Panjabi2 1Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India 2Department of Respiratory Medicine, Mata Chanan Devi Hospital, New Delhi, India This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. In susceptible individuals, inhalation of Aspergillus spores can affect the respiratory tract in many ways. These spores get trapped in the viscid spu- tum of asthmatic subjects which triggers a cascade of inflammatory reactions that can result in Aspergillus-induced asthma, allergic bronchopulmo- nary aspergillosis (ABPA), and allergic Aspergillus sinusitis (AAS). An immunologically mediated disease, ABPA, occurs predominantly in patients with asthma and cystic fibrosis (CF). A set of criteria, which is still evolving, is required for diagnosis. Imaging plays a compelling role in the diagno- sis and monitoring of the disease. Demonstration of central bronchiectasis with normal tapering bronchi is still considered pathognomonic in pa- tients without CF. Elevated serum IgE levels and Aspergillus-specific IgE and/or IgG are also vital for the diagnosis. Mucoid impaction occurring in the paranasal sinuses results in AAS, which also requires a set of diagnostic criteria. Demonstration of fungal elements in sinus material is the hall- mark of AAS.
    [Show full text]
  • Interstitial Lung Disease
    Interstitial Lung Disease Nitin Bhatt, MD Assistant Professor of Internal Medicine Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine Ohio State University Medical Center Interstitial Lung Disease Jim Allen, MD Professor of Internal Medicine Division of Pulmonary & Critical Care Medicine Ohio State University Medical Center 1 Case #1 Case #1 • 57 y.o. WM with a history of shortness of breath and cough that has been present for 1 year • Initially worse with walking, moderate exertion. No resting symptoms. • Now activity limiting • Associated with a dry, nonproductive cough • Negative cardiac evaluation • PMHx: HTN • Meds: HCTZ • SOCHx: 30 pack year smoking history, quit 10 years ago 2 Case #1 • PE: HR 78, BP 138/67, sats 96% on room air • Lungs with bibasilar dry crackles • Ext with clubbing • PFTs: • FVC 69% predicted • FEV1 72% • TLC 62% • DLCO 53% • 6 Minute walk: Walks 1100 feet with an initial sat of 96% dropping to 79% on room air Case #1 • CT scan • Subpleural fibrosis 3 Case #1 • CT scan • TtibTraction bronchi hitiectasis • • Honeycombing Case #1 • Lunggpy biopsy • Interstitial thickening • Temporal heterogeneity • Fibroblastic foci 4 Idiopathic Pulmonary Fibrosis • Most common ILD of unknown etiology • MilMainly aff fftects peopl e > >50 50 yo, mos t are over the age of 60 yo • Incidence is estimated at 7.4-10.7 cases per 100,000 per year • Prevalence of IPF is estimated at 13-20/100,000 • Most are current or former smokers • Potential risk factors for developing IPF include cigarette smoking, occupational/environmental
    [Show full text]
  • Frequently Asked Questions About Sinusitis Table of Contents
    FREQUENTLY ASKED QUESTIONS ABOUT SINUSITIS TABLE OF CONTENTS Chapter 1: Do I have acute sinusitis or chronic sinusitis? 3 Chapter 2: Do I need antibiotics for my acute sinusitis? 4 Chapter 3: What kind of chronic sinusitis do I have? 5 Chapter 4: Why do I have chronic sinusitis? 7 Chapter 5: What are my treatment options for chronic sinusitis? 9 Chapter 6: When should I consider surgery? 11 Chapter 7: Are my allergies causing my chronic sinusitis? 12 Chapter 8: Is there a connection between chronic sinusitis and asthma? 13 Chapter 9: What can I do to keep my chronic sinusitis under control? 14 Chapter 10: About Metropolitan ENT & Facial Plastic Surgery 15 DISCLAIMER: This information is for educational and informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read in this e-book. While all attempts have been made to verify information provided in this publication, the Publisher assumes no responsibility for errors, omissions, or contrary interpretation of the subject matter herein. The content of this e-book was developed and published by eos Healthcare Partners, LLC. Accordingly the information and material in this book is copyright, 2015 © eos Healthcare Partners, LLC.Therefore no part of this book may in any form be reproduced, stored, broadcast, sold or transmitted without the prior permission of the publisher, eos Healthcare Partners, LLC.
    [Show full text]
  • Defective Regulation of Immune Responses in Croup Due to Parainfluenza Virus
    716 WELLIVER ET AL. Science 221: 1067-1070 20. Mawhinney TP, Feather MS, Martinez JR, Barbero GJ 1979 The chronically 17. Quissell DO 1980 Secretory response of dispersed rat submandibular cells: I. reserpinized rat as an animal model for cystic fibrosis: acute effect of Potassium release. Am J Physiol 238:C90-C98 isoproterenol and pilocarpine upon pulmonary lavage fluid. Pediatr Res 18. Lowry OH, Rosebrough NF, Farrar AL, Randall RJ 195 1 Protein measurement 13:760-763 with the Folin phenol reagent. J Biol Chem 193:265-268 21. Frizzell RA, Fields M, Schultz SG 1979 Sodium-coupled chloride transport by 19. Perlmutter J, Martinez JR 1978 The chornically reserpinized rat as a possible epithelial tissues. Am J Physiol 236:FI-F8 model for cystic fibrosis: VII. Alterations in the secretory response to secretin 22. Welsh M 1983 Inhibition of chloride secretion by furosemide in canine tracheal and to cholecystokinin from the pancreas in vivo. Pediatr Res 12: 188- 194 epithelium. J Memb Biol71:219-226 003 1-3998/85/1907-07 16$02.00/0 PEDIATRIC RESEARCH Vol. 19, No. 7, 1985 Copyright O 1985 International Pediatric Research Foundation, Inc. Printed in U.S.A. Defective Regulation of Immune Responses in Croup Due to Parainfluenza Virus ROBERT C. WELLIVER, MARTHA SUN, AND DEBORAH RINALDO Department ofPediatrics, State University of New York at Buffalo, and Division of Infectious Diseases, Children S Hospital, Buffalo, New York 14222 ABSTRACT. In order to determine if defects in regulation Croup is a common respiratory illness of childhood, yet fairly of immune responses play a role in the pathogenesis of little is known about its pathogenesis.
    [Show full text]