Ep 1778618 B1

Total Page:16

File Type:pdf, Size:1020Kb

Ep 1778618 B1 (19) TZZ___T (11) EP 1 778 618 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: C07C 209/62 (2006.01) A61P 39/04 (2006.01) 25.12.2013 Bulletin 2013/52 C07C 211/10 (2006.01) A61K 31/352 (2006.01) C07C 5/00 (2006.01) C07D 233/26 (2006.01) (2006.01) (2006.01) (21) Application number: 05805036.0 C07C 57/145 C07C 57/15 C07C 55/10 (2006.01) C07C 209/48 (2006.01) C07C 211/14 (2006.01) C07D 233/02 (2006.01) (22) Date of filing: 19.07.2005 (86) International application number: PCT/IB2005/052421 (87) International publication number: WO 2006/027705 (16.03.2006 Gazette 2006/11) (54) SYNTHESIS OF TRIETHYLENETETRAMINES SYNTHESE VON TRIETHYLENETETRAMINEN SYNTHESE DE TRIETHYLENETETRAMINES (84) Designated Contracting States: (56) References cited: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR CS-B- 197 093 HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR • KOSCOVA S. ET AL.: ’A facile synthesis of selectively protected linear oligoamines’ (30) Priority: 19.07.2004 US 589080 P COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS vol. 68, no. 4, 2003, pages (43) Date of publication of application: 744 - 750, XP008096605 02.05.2007 Bulletin 2007/18 • DATABASE CAPLUS [Online] XP008096640 Retrieved from STN Database accession no. (114: (73) Proprietor: PhilERA New Zealand Limited 234954) & FUJITO H. ET AL.: ’A study of efficient Auckland (NZ) preparation of triethylenetetramine dihydrochloride for the treatment of Wilson’s (72) Inventors: disease and hygroscopicity of its capsule’ •JONAS,Marco YAKUZAIGAKU vol. 50, no. 4, 1990, pages 402 - CH-5502 Hunzenschwil (CH) 408 • VAULONT, Irene • DATABASE REGISTRY [Online] RN 81904-67-8, CH-5502 Hunzenschwil (CH) 16 November 1984 ’3- • SOI, Antonio Imidazolidinediethanamine, 2-phenyl-N,N’-bis CH-5502 Hunzenschwil (CH) (phenylmethylene)’, XP008096641 Retrieved • SCHMIDT, Gunther from STN CH-5502 Hunzenschwil (CH) • DATABASE CA [Online] XP008096639 Retrieved from STN Database accession no. (93:95005) & (74) Representative: Kiddle, Simon John et al PL 105 793 B1 Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS (GB) Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations. Notice of opposition shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention). EP 1 778 618 B1 Printed by Jouve, 75001 PARIS (FR) EP 1 778 618 B1 Description FIELD OF THE INVENTION 5 [0001] The field relates to chemicals and methods of chemical synthesis including, for example, novel methods for synthesis of triethylenetetramines and triethylenetetramine salts, and crystals and polymorphs thereof, as well as inter- mediates for, or within, said synthesis methods. BACKGROUND OF THE INVENTION 10 [0002] The following includes information that may be useful in understanding the present inventions. It is not an admission that any of the information provided herein is prior art, or relevant, to the presently described or claimed inventions, or that any publication or document that is specifically or implicitly referenced is prior art. [0003] Polyethylenepolyamines include triethylenetetramines that act as copper antagonists. Triethylenetetramine, 15 sometimes also referred to as trientine, N,N’-Bis(2-aminoethyl)-1,2-ethanediamine, 1,8-diamino-3,6-diazaoctane, 3,6- diazaoctane-1,8-diamine, 1,4,7,10-tetraazadecane, trien, TETA, TECZA, N,N’-Bis(aminoethyl)ethylenediamine, N,N’- Bis(2-aminoethyl)ethanediamine, and N, N’-Bis(2-aminoethyl)-ethylenediamine, is a copper chelating agent. Triethylene- tetramine is used as an epoxy curing agent. Merck Index, p. 9478 (10th Edition, 1983). It has also been used as a thermosetting resin, as a lubricating oil additive, and as an analytical reagent for copper and nickel id. Triethylenetetramine 20 dihydrochloride has also been used for treating individuals with Wilson’s disease. See, for example, id.; Dubois, R.S., Lancet 2(7676):775 (1970); Walshe, J.M., Q. J. Med. 42(167):441-52 (1973); Haslam, R. H., et al., Dev. Pharmacol. Ther. 1(5):318-24 (1980). It has also reportedly been used to treat individuals with primary biliary cirrhosis. See, for example, Epstein, O., et al., Gastroenterology 78(6):1442-45 (1980). In addition, trientine has been tested for inhibition of the spontaneous development of hepatitis and hepatic tumors in rats. See, for example, Sone, H., et al., Hepatology 25 23:764-70 (1996). United States Patent Nos. 6,897,243, 6,610,693 and 6,348,465 describe the use of copper binding compounds in the treatment of various disorders, including treatment of diabetes mellitus and complications thereof, including, for example, diabetic cardiomyopathy. [0004] Trientine was said to be used in the synthesis of benzylidene-(2-{3-[2-(benzylidene-amino)-ethyl]-2-phenyl- imidazolidin-1-yl}-ethyl)-amine in French Patent No. FR2810035 to Guilard et al. Cetinkaya, E., et al., "Synthesis and 30 characterization of unusual tetraaminoalkenes," J. Chem. Soc. 5:561-7 (1992), is said to be directed to synthesis of benzylidene-(2-{3-[2-(benzylidene-amino)-ethyl]-2-phenyl-imidazolidin-1-yl}-ethyl)-amine from trientine, as is Araki T., et al., "Site-selective derivatization of oligoethyleneimines using five- membered-ring protection method," Macromol., 21: 1995-2001 (1988). Triethylenetetramine may reportedly also be used in the synthesis of N-methylated triethylenete- tramine, as reported in United States Patent No: 2,390,766, to Zellhoefer et al. 35 [0005] Synthesis of polyethylenepolyamines, including triethylenetetramines, from ethylenediamine and morioeth- anolamine using pelleted group IVb metal oxide-phosphate type catalysts was reported by Vanderpool et al. in United States Patent No. 4,806,517. Synthesis of triethylenetetramine from ethylenediamine and ethanolamine was also pro- posed in United States Patent No. 4,550,209, to Unvert et al. United States Patent No. 5,225,599, to King et al. is said to be directed to the synthesis of linear triethylene tetramine by condensation of ethylenediamine and ethylene glycol 40 in the presence of a catalyst. Joint production of triethylenetetramine and 1-(2-aminoethyl)-aminoethyl-piperazine was proposed by Borisenko et al. in U.S.S.R. Patent No. SU1541204. United States Patent No. 4,766,247 and European Patent No. EP262562, both to Ford et al. , reported the preparation of triethylenetetramine by reaction of an alkanolamine compound, an alkaline amine and optionally either a primary or secondary amine in the presence of a phosphorous containing catalyst, for example phosphoric acid on silica- alumina or Group IIIB metal acid phosphate, at a temperature 45 from about 175°C to 400°C under pressure. These patents indicate that the synthetic method used therein was as set forth in United States Patent No. 4,463,193, to Johnson. The Ford et al. ’247 patent is also said to be directed to color reduction of polyamines by reaction at elevated temperature and pressure in the presence of a hydrogenation catalyst and a hydrogen atmosphere. European Patent No. EP450709 to King et al. is said to be directed to a process for the preparation of triethylenetetramine and N-(2-aminoethyl)ethanolamine by condensation of an alkylenamine and an 50 alkylene glycol in the presence of a condensation catalyst and a catalyst promoter at a temperature in excess of 260 °C. [0006] Russian Patent No. RU2186761, to Zagidullin, proposed synthesis of diethylenetriamine by reaction of dichlo- roethane with ethylenediamine. Ethylenediamine has previously been said to have been used in the synthesis of N- carboxylic acid esters as reported in United States Patent No. 1,527,868, to Hartmann et al. [0007] Japanese Patent No. 06065161 to Hara et al. is said to be directed to the synthesis of polyethylenepolyamines 55 by reacting ethylenediamine with ethanolamine in the presence of silica- treated Nb205 supported on a carrier. Japanese Patent No. JP03047154 to Watanabe et al., is said to be directed to production of noncyclic polyethylenepolyamines by reaction of ammonia with monoethanolamine and ethylenediamine. Production of non-cyclic polyethylenepolyamines by reaction of ethylenediamine and monoethanolamine in the presence of hydrogen or a phosphorous- containing sub- 2 EP 1 778 618 B1 stance was said to be reported in Japanese Patent No. JP03048644. Regenerative preparation of linear polyethylenep- olyamines using a phosphorous-bonded catalyst was proposed in European Patent No. EP 115,138, to Larkin et al. [0008] A process for preparation of alkyleneamines in the presence of a niobium catalyst was said to be provided in European Patent No. 256,516, to Tsutsumi et al. United States Patent No. 4,584,405, to Vanderpool, reported the 5 continuous synthesis of essentially noncyclic polyethylenepolyamines by reaction of monoethanolamine with ethylen- ediamine in the presence of an activated carbon catalyst under a pressure between about 500 to about 3000 psig., and at a temperature of between about 200°C to about 400 °C. Templeton,et al., reported on the preparation of linear polyethylenepolyamides asserted to result from reactions employing silica-alumina catalysts in European Patent No. EP150,558. 10 [0009] Production of triethylenetetramine dihydrochloride was said to have been reported in Kuhr et al., Czech Patent No. 197,093, via conversion of triethylenetetramine to crystalline tetrahydrochloride and subsequently to triethylenete- tramine dihydrochloride. "A study of efficient preparation of triethylenetetramine dihydrochloride for the treatment of Wilson’s disease and hygroscopicity of its capsule," Fujito, et al., Yakuzaigaku, 50:402-8 (1990), is also said to be directed to production of triethylenetetramine. 15 [0010] Preparation of triethylenetetramine salts used for the treatment of Wilson’s disease was said to be reported in.
Recommended publications
  • Gasket Chemical Services Guide
    Gasket Chemical Services Guide Revision: GSG-100 6490 Rev.(AA) • The information contained herein is general in nature and recommendations are valid only for Victaulic compounds. • Gasket compatibility is dependent upon a number of factors. Suitability for a particular application must be determined by a competent individual familiar with system-specific conditions. • Victaulic offers no warranties, expressed or implied, of a product in any application. Contact your Victaulic sales representative to ensure the best gasket is selected for a particular service. Failure to follow these instructions could cause system failure, resulting in serious personal injury and property damage. Rating Code Key 1 Most Applications 2 Limited Applications 3 Restricted Applications (Nitrile) (EPDM) Grade E (Silicone) GRADE L GRADE T GRADE A GRADE V GRADE O GRADE M (Neoprene) GRADE M2 --- Insufficient Data (White Nitrile) GRADE CHP-2 (Epichlorohydrin) (Fluoroelastomer) (Fluoroelastomer) (Halogenated Butyl) (Hydrogenated Nitrile) Chemical GRADE ST / H Abietic Acid --- --- --- --- --- --- --- --- --- --- Acetaldehyde 2 3 3 3 3 --- --- 2 --- 3 Acetamide 1 1 1 1 2 --- --- 2 --- 3 Acetanilide 1 3 3 3 1 --- --- 2 --- 3 Acetic Acid, 30% 1 2 2 2 1 --- 2 1 2 3 Acetic Acid, 5% 1 2 2 2 1 --- 2 1 1 3 Acetic Acid, Glacial 1 3 3 3 3 --- 3 2 3 3 Acetic Acid, Hot, High Pressure 3 3 3 3 3 --- 3 3 3 3 Acetic Anhydride 2 3 3 3 2 --- 3 3 --- 3 Acetoacetic Acid 1 3 3 3 1 --- --- 2 --- 3 Acetone 1 3 3 3 3 --- 3 3 3 3 Acetone Cyanohydrin 1 3 3 3 1 --- --- 2 --- 3 Acetonitrile 1 3 3 3 1 --- --- --- --- 3 Acetophenetidine 3 2 2 2 3 --- --- --- --- 1 Acetophenone 1 3 3 3 3 --- 3 3 --- 3 Acetotoluidide 3 2 2 2 3 --- --- --- --- 1 Acetyl Acetone 1 3 3 3 3 --- 3 3 --- 3 The data and recommendations presented are based upon the best information available resulting from a combination of Victaulic's field experience, laboratory testing and recommendations supplied by prime producers of basic copolymer materials.
    [Show full text]
  • Food and Drugs
    21 Part 170 to 199 Revised as of April 1, 2001 Food and Drugs Containing a codification of documents of general applicability and future effect As of April 1, 2001 With Ancillaries Published by Office of the Federal Register National Archives and Records Administration A Special Edition of the Federal Register VerDate 11<MAY>2000 11:38 Apr 16, 2001 Jkt 194064 PO 00000 Frm 00001 Fmt 8091 Sfmt 8091 Y:\SGML\194064F.XXX pfrm02 PsN: 194064F U.S. GOVERNMENT PRINTING OFFICE WASHINGTON : 2001 For sale by the Superintendent of Documents, U.S. Government Printing Office Internet: bookstore.gpo.gov Phone: (202) 512-1800 Tax: (202) 512-2250 Mail Stop: SSOP, Washington, DC 20402–0001 VerDate 11<MAY>2000 11:38 Apr 16, 2001 Jkt 194064 PO 00000 Frm 00002 Fmt 8092 Sfmt 8092 Y:\SGML\194064F.XXX pfrm02 PsN: 194064F Table of Contents Page Explanation ................................................................................................ v Title 21: Chapter I—Food and Drug Administration, Department of Health and Human Services (Continued) ................................................. 3 Finding Aids: Material Approved for Incorporation by Reference ............................ 573 Table of CFR Titles and Chapters ....................................................... 587 Alphabetical List of Agencies Appearing in the CFR ......................... 605 Redesignation Table ............................................................................ 615 List of CFR Sections Affected ............................................................. 617
    [Show full text]
  • Electronic Supplementary Information For
    Electronic Supplementary Material (ESI) for Molecular Systems Design & Engineering. This journal is © The Royal Society of Chemistry 2018 Electronic supplementary information for Understanding structural adaptability: a reactant informatics approach to experiment design Rosalind J. Xu, Jacob H. Olshansky, Philip D. F. Adler, Yongjia Huang, Matthew D. Smith, Matthias Zeller,† Joshua Schrier and Alexander J. Norquist Department of Chemistry, Haverford College, Haverford PA 19041 † Department of Chemistry, Purdue University, West Lafayette IN Author to whom correspondence should be addressed. Haverford College 370 Lancaster Avenue Haverford PA, 19041 USA tel (610) 896 2949 fax (610) 896 4963 email [email protected] http://www.haverford.edu/chem/Norquist/ Figure S1. Three dimensional packing of [C4H14N2]2[VO(SeO3)(HSeO3)]6·5H2O (1). Green octahedra represent [VO6] while purple, red, blue, white and gray spheres represent selenium oxygen, nitrogen, carbon and hydrogen atoms, respectively. Selected hydrogen atoms have been removed for clarity. Figure S2. Three dimensional packing of [C8H26N4][VO(SeO3)(HSeO3)]6·6H2O (3). Green octahedra represent [VO6] while purple, red, blue, white and gray spheres represent selenium oxygen, nitrogen, carbon and hydrogen atoms, respectively. Selected hydrogen atoms have been removed for clarity. Figure S3. (a) One-dimensional chain SBU and (b) and (c) two slice connectivities in [C4H12N2][(VO)3(SeO3)(HSeO3)4]·H2O (4). Green polyhedra represent [VO6] and [VO5] while purple, red, and gray spheres represent selenium oxygen, and hydrogen atoms, respectively. Figure S4. 10-fold cross validation results for the decision trees in this study. Figure S5. Decision tree containing the 75 historical reactions and the 128 reactions from the fractional factorial analysis.
    [Show full text]
  • EPOXY CURING AGENTS Product Overview Guide
    EPOXY CURING AGENTS Product Overview Guide NORTH AMERICA EPOXY CURING AGENTS A Robust Toolbox to Meet Diverse Formulation and End Use Requirements With a heritage built on more than 50 continuous years in the industry, Dow is the reliable leader in innovative epoxy product and technology solutions. Dow offers a robust portfolio of epoxy products, including a diverse range of curing agent chemistries and individual grades, to help meet specific formulating and application requirements. To meet increased demand for environmentally responsible formulations, our line also includes low emission and waterborne curing agents. 2 Dow leadership in epoxy technology is demonstrated by innovative technology, high quality products and attention to customer service. In addition to providing one of the broadest epoxy offerings today, our epoxy innovation pipeline – part of Dow’s $1.6 billion annual investment in research & development – ensures that the epoxy products you will require tomorrow are being created by Dow today. Beyond technology development, we are also a source of technical support to help you apply our solutions effectively so customers achieve desired results. Our comprehensive service model – which combines the Dow epoxy sales organization and our R&D and Technical Service Center in Freeport, Texas – gives you access to local know-how and support and world-class technical resources. Our commitment to the epoxy industry includes adhering to the highest standards for safety in the manufacture, storage, transport, use and disposal of our products. This guide presents a comprehensive listing of curing agents available from Dow. For assistance in choosing the right product for your formulation, or to investigate emerging innovation, please contact us.
    [Show full text]
  • Dendrimer-Functionalized Hybrid Materials Based on Silica As Novel Carriers of Bioactive Acids
    molecules Article Dendrimer-Functionalized Hybrid Materials Based on Silica as Novel Carriers of Bioactive Acids Mateusz Pawlaczyk * and Grzegorz Schroeder Faculty of Chemistry, Adam Mickiewicz University in Pozna´n,Uniwersytetu Pozna´nskiego 8, 61-614 Pozna´n, Poland; [email protected] * Correspondence: [email protected]; Tel.: +48-61-829-17-97 Received: 9 May 2020; Accepted: 3 June 2020; Published: 8 June 2020 Abstract: One of the major goals in the materials science is the design and development of non-toxic, versatile, and efficient drug delivery systems. The study reported in this paper concerns the syntheses of poly(amidoamine) (PAMAM) dendrimers with tris(2-aminoethyl)amine as an amine core and different terminal amines, and their attachment to silica matrix. The obtained ethylenediamine (EDA), triethylenetetramine (TETA), tris(2-aminoethyl)amine (TREN) and 4,7,10-trioxa-1,13-tridecanediamine (TRI-OXA) dendrimers were introduced to the support surface via an epoxy linker, leading to a loading 1 efficiency in the range of 0.054–0.113 mmol g− , determined using elemental and thermogravimetric analyses. The materials exhibited high adsorption capacities towards the chosen model drugs: folic, salicylic and nicotinic acid. The investigated adsorption processes were found to follow the Freundlich isotherm model, with indication of the drugs’ structure influence on the binding efficiency. Drug-loaded hybrid materials were also described for in vitro drug release in three pH-different paraphysiological media. The highest percentage release was obtained in the tests performed at pH 2.0, ranging between 35.42 and 99.83%. Satisfactory results and the versatility of PAMAM dendrimers may lead to the application of such materials not only as drug carriers dedicated to a wide range of pharmaceutics, but also as analytical tools for pre-concentration and/or the determination of biocompound contamination in samples.
    [Show full text]
  • Tetraethylenepentamine Cas N°: 112-57-2
    OECD SIDS TETRAETHYLENEPENTAMINE FOREWORD INTRODUCTION TETRAETHYLENEPENTAMINE CAS N°: 112-57-2 UNEP PUBLICATIONS 1 OECD SIDS TETRAETHYLENEPENTAMINE SIDS Initial Assessment Report For 13th SIAM (Bern, Switzerland November 6-9, 2001) Chemical Name: Tetraethylenepentamine CAS No.: 112-57-2 Sponsor Country: USA SIDS Contact: Oscar Hernandez United States Environmental Protection Agency (7403M) ICC Building, room 6220A 1200 Pennsylvania Avenue, NW Washington, DC 20460 History: Tetraethylenepentamine was volunteered for the U.S. HPV program and subsequently the ICCA program by the Ethyleneamines Product Stewardship Discussion Group in the U.S. Use of data from the analog triethylenetetramine is proposed to reduce testing needs. The panel/consortia (Dow, UCC and Azko-Nobel) searched company files and publicly available databases to obtain data on TEPA. The “Environmental Risk Assessment of Complexing Agents” submitted by Germany was also included in this evaluation. Testing: No testing (x) Testing ( ) Comments: Deadline for Circulation: September 14, 2001 Date of Circulation: 2 UNEP Publications OECD SIDS TETRAETHYLENEPENTAMINE SIDS INITIAL ASSESSMENT PROFILE CAS No. 112-57-2 Chemical Name 3,6,9-triazaundecamethylenediamine; tetraethylenepentamine (TEPA) Structural Formula NH2CH2CH2NHCH2CH2NHCH2CH2NHCH2CH2NH2 RECOMMENDATIONS The chemical is currently of low priority for further work. SUMMARY CONCLUSIONS OF THE SIAR Use of Analog TETA to suppleme nt TEPA data Tetraethylenepentamine (TEPA) is similar toxicologically to triethylenetetramine (TETA) based on its structure and chelation properties. Therefore, data obtained using TETA have been used to address the endpoints for reproductive and developmental toxicity. Human Health Tetraethylenepentamine (TEPA) has a low acute toxicity when administered orally to rats (LD50 = 3250 mg/kg). In an acute inhalation toxicity study with saturated vapor and whole body exposure, the LC50 was calculated to be >9.9 ppm (highest dose tested).
    [Show full text]
  • METHOD FINDER (Key on Page MF!34]
    METHOD FINDER (Key on page MF!34] Meth Flow Rate Vol. (L) Extraction Analytical Chemical No. Method Name (L/min) Technique Sampler min max Acenaphthene 5506 PO LYN UC LEAR ARO MATIC 2.0 200 - 1000 aceto nitrile HPLC!FL/UV PTFE & XAD!2 HYDROCARBO NS by HPLC Acenaphthene 5515 PO LYN UC LEAR ARO MATIC 2.0 200 - 1000 varies GC!FID PTFE & XAD!2 HYDROCARBONS Acenaphthylene 5506 PO LYN UC LEAR ARO MATIC 2.0 200 - 1000 aceto nitrile HPLC!FL/UV PTFE & XAD!2 HYDROCARBO NS by HPLC Acenaphthylene 5515 PO LYN UC LEAR ARO MATIC 2.0 200 ! 1000 varies GC!FID PTFE & XAD!2 HYDROCARBONS Acetaldehyde 2018 ALIPHATIC ALDEHYDES 0.1 - 1.5 1 - 15 ACN HPLC/UV SG-DNPH Acetaldehyde 2538 ACETALDEHYDE 0.01 - 0.05 1 ! 12 tol GC!FID XAD!2/HMP Acetaldehyde 2539 ALDEHYDES, SCREENING 0.01 - 0.05 5 - 5 tol GC!FID/MS XAD-2/HMP Acetaldehyde 3507 ACETALDEHYDE 0.1 - 0.5 6 - 60 reag HPLC!UV BuB Ac etic acid 1603 AC ETIC AC ID 0.01 - 0.1 20 - 300 formic a GC!FID CCT Acetic anhydride 3506 ACETIC ANHYDRIDE 0.2 - 1.0 25 - 100 reag VIS BuB Ac eto in 2558 AC ETO IN 0.01 - 0.2 1 - 10 Acet-Meth GC-FID A-CMS Acetone 1300 KETONES I 0.01 - 0.2 0.5 - 3 CS2 GC!FID CCT Acetone 2549 VOLATILE ORGANIC CPDS 0.01 - 0.05 1 - 6 thermal TD/GC!MS TD (Screening) Acetone 3800 ORGANIC AND INORGANIC GASES 0.1 - 2.0 Instr.
    [Show full text]
  • Chemicals Subject to TSCA Section 12(B) Export Notification Requirements (January 16, 2020)
    Chemicals Subject to TSCA Section 12(b) Export Notification Requirements (January 16, 2020) All of the chemical substances appearing on this list are subject to the Toxic Substances Control Act (TSCA) section 12(b) export notification requirements delineated at 40 CFR part 707, subpart D. The chemicals in the following tables are listed under three (3) sections: Substances to be reported by Notification Name; Substances to be reported by Mixture and Notification Name; and Category Tables. TSCA Regulatory Actions Triggering Section 12(b) Export Notification TSCA section 12(b) requires any person who exports or intends to export a chemical substance or mixture to notify the Environmental Protection Agency (EPA) of such exportation if any of the following actions have been taken under TSCA with respect to that chemical substance or mixture: (1) data are required under section 4 or 5(b), (2) an order has been issued under section 5, (3) a rule has been proposed or promulgated under section 5 or 6, or (4) an action is pending, or relief has been granted under section 5 or 7. Other Section 12(b) Export Notification Considerations The following additional provisions are included in the Agency's regulations implementing section 12(b) of TSCA (i.e. 40 CFR part 707, subpart D): (a) No notice of export will be required for articles, except PCB articles, unless the Agency so requires in the context of individual section 5, 6, or 7 actions. (b) Any person who exports or intends to export polychlorinated biphenyls (PCBs) or PCB articles, for any purpose other than disposal, shall notify EPA of such intent or exportation under section 12(b).
    [Show full text]
  • Elastomer Fluid Compatibility Chart
    ELASTOMER FLUID COMPATIBILITY CHART Recommended: 1 Not Recommended:4 Probably Satisfactory: 2 Insuficient Data: X Marginal: 3 Chemical NBR EPDM FKM PTFE 0-Chloronaphthalene 4 4 1 X 0-Chlorphenol 4 4 1 X 0-Dichlorobenzene 4 4 1 X 1-Butene, 2-Ethyl 1 4 1 X 1-Chloro 1-Nitro Ethane 4 4 4 X 90, 100, 150, 220, 300, 500 4 1 1 X Abietic Acid X X X X Acetaldehyde 3 2 4 X Acetamide 1 1 3 X Acetanilide 3 1 3 X Acetic Acid 5% 2 1 1 X Acetic Acid, 30% 2 1 3 X Acetic Acid, Glacial 2 2 4 X Acetic Acid, Hot, High Pressure 4 3 4 X Acetic Anhydride 4 2 4 X Acetoacetic Acid 3 1 3 X Acetone 4 1 4 X Acetone Cyanohydrin 3 1 3 X Acetonitrile 3 1 1 X Acetophenetidine 2 4 1 X Acetophenone 4 1 4 X Acetotoluidide 2 4 1 X Acetyl Acetone 4 1 4 X Acetyl Bromide 4 1 1 1 Acetyl Chloride 4 4 1 X Acetylacetone 4 1 4 X Acetylene 1 1 1 X Acetylene Tetrabromide 4 1 1 X Acetylene Tetrachloride 4 1 1 X Acetylsalicylic Acid 2 4 1 X Acids, Non-organic X X X X Acids, Organic X X X X Aconitic Acid X X X X Acridine X X X X Acrolein 3 1 3 X Acrylic Acid 2 3 4 X Acrylonitrile 4 4 3 X Adipic Acid 1 2 2 X Aero Lubriplate 1 4 1 X Aero Shell 17 Grease 1 4 1 X Page 1 of 61 ELASTOMER FLUID COMPATIBILITY CHART Recommended: 1 Not Recommended:4 Probably Satisfactory: 2 Insuficient Data: X Marginal: 3 Chemical NBR EPDM FKM PTFE Aero Shell 1AC Grease 1 4 1 X Aero Shell 750 2 4 1 X Aero Shell 7A Grease 1 4 1 X Aerosafe 2300 4 1 4 X Aerosafe 2300W 4 1 4 X Aerozene 50 (50% Hydrazine 50% UDMH) 3 1 4 X Air, 1 1 1 X Air, 200 - 300° F 3 2 1 X Air, 300 - 400° F 4 4 1 X Air, 400 - 500° F 4 4 3 X Air,
    [Show full text]
  • Study of Potential Impact of Hydraulic Fracturing on Drinking Water
    EPA 601/R-12/011 | December 2012 | www.epa.gov/hfstudy Study of the Potential Impacts of Hydraulic Fracturing on Drinking Water Resources PROGRESS REPORT United States Environmental Protection Agency Office of Research and Development this page intentially left blank Study of the Potential Impacts of Hydraulic Fracturing on Drinking Water Resources PROGRESS REPORT US Environmental Protection Agency Office of Research and Development Washington, DC December 2012 EPA/601/R-12/011 Study of the Potential Impacts of Hydraulic Fracturing on Drinking Water Resources: Progress Report December 2012 Disclaimer Mention of trade names or commercial products does not constitute endorsement or recommendation for use. ii Study of the Potential Impacts of Hydraulic Fracturing on Drinking Water Resources: Progress Report December 2012 Table of Contents Executive Summary .................................................................................................................................... 1 1. Introduction ......................................................................................................................................... 5 1.1. Stakeholder Engagement ...................................................................................................... 6 2. Overview of the Research Program .................................................................................................. 8 2.1. Research Questions ...........................................................................................................
    [Show full text]
  • Gad Compounds Assessed
    Name CAS # ((5-Amino-2-carboxyphenyl)thio)gold sodium salt 17010-23-0 (2-Hydroxypropyl)-γ-cyclodextrin 128446-34-4 (4-hydroxy-4-isobutylpiperidin-1-yl)(1H-imidazol-1-yl)methanone (5aR, 9aR)-octahydrobenzo[e][1,3,2]dioxathiepine 3,3- (LMPC) 1-myristoyl-2-hydroxy-sn-glycero-3-phosphocholine 20559-16-4 (Trimethylsilyl)acetic acid 2345-38-2 (Z) 7-Hexadecenal 56797-40-1 (Z)-2-chloro-4-(diethylamino)but-2-en-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate (Z)-3-chloro-4-(diethylamino)but-2-en-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate (Z,Z,Z) 8,11,14-Eicosatrienoic acid 1783-84-2 1-(2-butoxyethoxy)-ethanol 5446-78-5 1,1,1,3,5,5,7,7,7-Nonamethyl-3-(trimethylsiloxy) tetrasiloxane 38146-99-5 1,10-decanedithiol 1191-67-9 1,1'-bicyclohexyl-4,4'-diol 20601-38-1 1,1-bis(p-ethoxyphenyl)-2,2-dimethylpropane 27955-87-9 1,1-carbonyldiimidazole (CDI) 530-62-1 1,1-cyclohexanedithiol 3855-24-1 1,2,3,4-Tetrahydronaphthalene 119-6-2 1,2,3-trichloro-2-methylpropane 1871-58-5 1,2,3-triethylbenzene 42205-08-3 1,2,4-benzenetriol 533-73-3 1,2,4-triethylbenzene 877-44-1 1,2-cyclohexanediamine 694-83-7 1,2-cyclohexanedicarboxylic acid 1687-30-5 1,2-cyclohexanediol 931-17-9 1,2-dichlorobenzene 95-50-1 1,2-Ethanediamine 107-15-3 1,2-ethanedithiol 540-63-6 1,2-propanediol, monobutyl ether 29387-86-8 1,3,5-Tributyl-2,4,6-trioxo-hexahydro-striazine 846-74-2 1,3,5-triethylbenzene 102-25-0 1,3,5-Trioxane 110-88-3 1,3:2,4-Bis(3,4-dimethylbenzylidene)sorbitol 135861-56-2 1,3-Bis(diallylamino)-2-propanol 4831-46-3 1,3-butanediol 107-88-0 1,3-cycloheptadiene 4054-38-0 1,3-cyclohexanedicarboxylic
    [Show full text]
  • Triethylenetetramine
    Triethylenetetramine sc-251328 Material Safety Data Sheet Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Triethylenetetramine STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA FLAMMABILITY1 HEALTH3 HAZARD INSTABILITY0 SUPPLIER Santa Cruz Biotechnology, Inc. 2145 Delaware Avenue Santa Cruz, California 95060 800.457.3801 or 831.457.3800 EMERGENCY ChemWatch Within the US & Canada: 877-715-9305 Outside the US & Canada: +800 2436 2255 (1-800-CHEMCALL) or call +613 9573 3112 SYNONYMS C6-H18-N4, (H2NCH2CH2NHCH2)2, H2N(C2-H2-NH)3H, NH2(CH2)2NH(CH2)2NH(CH2)2NH2, "N, N' -bis(2-aminoethyl)-1, 2-diaminoethane", "1, 8-diamino-3, 6-diazooctane", "N, N' -bis(2-aminoethyl) ethylenediamine", "3, 6-diazaoctane-1, 8-diamine", tetralin, "1, 2-ethanediamine, N, N' -bis(2-aminoethyl)-", "ethylenediamine, N, N' -bis(2-aminoethyl)-", "1, 4, 7, 10-tetraazadecane", "Araldite Hardener HY 951", TETA, "DEH 24", "Araldite HY 951", TEZCA, "GE Material D5F15B1", "Hysol H2-3404", "Ludowici Wear Resist Trowelable (Part B)", Trien, Trientine Section 2 - HAZARDS IDENTIFICATION CHEMWATCH HAZARD RATINGS Min Max Flammability: 1 Toxicity: 2 Body Contact: 3 Min/Nil=0 Low=1 Reactivity: 1 Moderate=2 High=3 Chronic: 3 Extreme=4 1 of 9 CANADIAN WHMIS SYMBOLS EMERGENCY OVERVIEW RISK Harmful in contact with skin. Causes burns. Risk of serious damage to eyes. May cause SENSITISATION by skin contact. Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. POTENTIAL HEALTH EFFECTS ACUTE HEALTH EFFECTS SWALLOWED ! The material can produce chemical burns within the oral cavity and gastrointestinal tract following ingestion.
    [Show full text]