Case Report Advanced Cutaneous Leiomyosarcoma of the Forearm Gerardo Cazzato 1 , Maria Chiara Sergi 2, Sara Sablone 3 , Anna Colagrande 1, Teresa Lettini 1,* , Francesco Fanelli 1, Umberto Orsini 4 and Giuseppe Ingravallo 1 1 Section of Pathology, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, Italy; [email protected] (G.C.); [email protected] (A.C.); [email protected] (F.F.); [email protected] (G.I.) 2 Section of Medical Oncology, Department of Biomedical Sciences and Clinical Oncology (DIMO), University of Bari Aldo Moro, 70124 Bari, Italy; [email protected] 3 Section of Forensic Medicine, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, 70124 Bari, Italy; [email protected] 4 Orthopedics Section, Department of Medical Sciences of Basis, Neurosciences and Organs of Sense, University of Bari Aldo Moro, 70124 Bari, Italy; [email protected] * Correspondence: [email protected] Abstract: Leiomyosarcoma is a malignant smooth muscle neoplasm, which is traditionally divided into superficial and deep tumors. Superficial leiomyosarcomas are quite rare entities, accounting for approximately 7% of soft tissue neoplasms and 0.04% of all cancers. Here we describe a rare case of advanced primary cutaneous leiomyosarcoma (PCL) in a 93-year-old woman, highlighting the considerable size of the lesion and the correct surgical and oncological management. The clinical story began about 4 years ago, and the neoplasia was treated only with local radiotherapy, but the patient suffered from a dramatic volumetric increase of the right arm sarcoma one year ago. Then, an amputation of the limb was performed without following adjuvant chemotherapy. Currently, she Citation: Cazzato, G.; Sergi, M.C.; does not show signs of recurrence and is in good shape. Sablone, S.; Colagrande, A.; Lettini, T.; Fanelli, F.; Orsini, U.; Ingravallo, G. Advanced Cutaneous Keywords: primary cutaneous leiomyosarcoma (PCL); skin; differential diagnosis Leiomyosarcoma of the Forearm. Dermatopathology 2021, 8, 40–44. https://doi.org/10.3390/ dermatopathology8010008 1. Introduction Leiomyosarcoma is a malignant smooth muscle neoplasm, which is traditionally di- Academic Editor: Gürkan Kaya vided into superficial and deep tumors. Superficial leiomyosarcomas are quite rare entities, accounting for approximately 7% of soft tissue neoplasms and 0.04% of all cancers [1]. Received: 10 February 2021 Based on localization, superficial tumors are further subclassified in dermal and subcu- Accepted: 24 February 2021 taneous forms; traditionally, it is supposed that the dermal forms have a less aggressive Published: 27 February 2021 behavior than lesions primitively localized in the subcutaneous [1]. We report a rare case of primary cutaneous leiomyosarcoma (PCL) highlighting the considerable size of the Publisher’s Note: MDPI stays neutral lesion and the correct surgical and oncological management. About 3 years after the initial with regard to jurisdictional claims in diagnosis, the neoplastic lesion reported an almost “dramatic” volumetric increase in the published maps and institutional affil- previous 6 months. iations. 2. Case Report A 93-year-old woman presented herself to the Complex Operating Unit of Orthopedics of Aldo Moro University of Bari for a worsening of her health conditions. About 3 years Copyright: © 2021 by the authors. earlier, he had been diagnosed with a primary cutaneous leiomyosarcoma at another Licensee MDPI, Basel, Switzerland. hospital, which had been treated with local radiotherapy. In recent months, he had noticed This article is an open access article a progressive increase in the size of the lesion. On clinical examination, the woman distributed under the terms and showed a lesion of 10.3 × 9.1 × 2.4 cm located in the right arm, extensively ulcerated, with conditions of the Creative Commons polycyclic contours, with hemorrhagic zone (Figure1A). Radiographic image confirmed Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ the destructive appearance of the neoplasm, which, in addition to infiltrating the subcutis 4.0/). and the underlying bone (humerus) (Figure1B). Dermatopathology 2021, 8, 40–44. https://doi.org/10.3390/dermatopathology8010008 https://www.mdpi.com/journal/dermatopathology Dermatopathology 2021, 8 41 Dermatopathology 2021, 8 41 appearance of the neoplasm, which, in addition to infiltrating the subcutis and the under- lying bone (humerus) (Figure 1B). FigureFigure 1. 1. UlceratedUlcerated cutaneous cutaneous lesion lesion (A (A).). Radiographic Radiographic image image (B (B) )shows shows a a big big lesion lesion of of soft soft tissue tissue that that has has infiltrated infiltrated underlyingunderlying bone bone plans, plans, in in particular particular proximal proximal radio, radio, which which is is almost almost completely completely eroded. eroded. Th Thee proximal proximal ulna ulna also also appears appears infiltratedinfiltrated and and partly partly rare. rare. AfterAfter an an interdisciplinary interdisciplinary consultation, consultation, it it was was decided decided to to amputate amputate the the limb limb as as the the patient’spatient’s age age did did not not indicate indicate the the use use of of syst systemicemic chemotherapy, chemotherapy, a a much-debated much-debated point point in in thethe Literature Literature (see (see Section Section 3).3). Pathological Pathological gross gross examination described a surgical sample consistingconsisting of of a a lozenge lozenge of skin, subcutis, and musclemuscle fasciafascia ofof11.2 11.2× × 9.0 × 3.03.0 cm, cm, thatthat was was almostalmost entirely occupiedoccupied by by an an ulcerated, ulcerated, grey-whitish grey-whitish lesion lesion with with irregular irregular contours, contours, which whichextensively extensively infiltrated infiltrated the subcutis, the subcutis, with no with apparent no apparent cleavage cleavage plane. Adequate plane. Adequate sampling samplingof the lesion of the was lesion carried was out, carried paying out, particular paying particular attention attention to the surgical to the surgical resection resection margins. margins.After tissue processing, paraffin embedding, microtome cutting and routine haematoxylin- eosinAfter staining, tissue theprocessing, microscopic paraffin examination embedding, showed microtome at low cutting magnification and routine (Figure haematoxy-2), at lin-eosinthe dermal staining, level, the the microscopic presence of aexamination proliferation showed of variously at low intertwined magnification atypical (Figure spindle 2), at thecells dermal was described, level, the presence which tended of a proliferation to ulcerate theof variously overlying intertwined epidermis andatypical infiltrate spindle the cellssubcutaneous. was described, Immunohistochemistry which tended to ulcerate was positive the overlying for muscle epidermis markers and such infiltrate as smooth the subcutaneous.muscle actin (SMA). Immunohistochemistry (Figure3C). About was 1 year positive after for the muscle amputation markers surgery, such theas smooth patient muscleshowed actin no signs(SMA). of (Figure recurrence 3C). and About is in 1 goodyear after health. the Furthermore,amputation surgery, the decision the patient made showedin the multidisciplinary no signs of recurrence team notand tois submitin good the health. patient Furthermore, to adjuvant the chemotherapy decision made after in thesurgery, multidisciplinary by virtue of herteam age, not appears to submit to havethe patient had no to negative adjuvant effects. chemotherapy Additionally, after it sur- was gery,not considered by virtue of necessary her age, to appears subject to the have patient had to no radiotherapy, negative effects. as the Additionally, minimum criteria it was of notoncological considered surgical necessary radicality to subject were the met patien (see Sectiont to radiotherapy,3). as the minimum criteria of oncologicalAt higher surgical magnification, radicality the were neoplastic met (see cells Section showed 3). pleomorphic, nucleolated, hyper- chromatic nuclei, and moderate to abundant eosinophilic cytoplasm: numerous typical and atypical mitotic figures, extensive necrosis, and hemorrhages were present together with areas of apparent dedifferentiation (Figure3A,B). The tumor cells displayed consistent smooth muscle actin (Figure3C), desmin immunoreactivity, and sporadic positivity for Actin HHF35. Based on the above features, the diagnosis of cutaneous leiomyosarcoma was made. Dermatopathology 2021, 8 42 Dermatopathology 2021, 8 42 Dermatopathology 2021, 8 42 Figure 2. Histopathological features of the primary cutaneous leiomiosarcoma at low magnification. At higher magnification, the neoplastic cells showed pleomorphic, nucleolated, hy- perchromatic nuclei, and moderate to abundant eosinophilic cytoplasm: numerous typical and atypical mitotic figures, extensive necrosis, and hemorrhages were present together with areas of apparent dedifferentiation (Figure 3A,B). The tumor cells displayed con- sistent smooth muscle actin (Figure 3C), desmin immunoreactivity, and sporadic positiv- Figure 2. Histopathological features of the primary cutaneous leiomiosarcoma at low magnification. Figure 2. Histopathologicality for Actin features HHF35. of theBased primary on the cutaneous above features, leiomiosarcoma the diagnosis at low magnification. of cutaneous leiomyosar- coma was made. At higher magnification, the neoplastic