Bioactive Glasses: from Parent 45S5 Composition to Scaffold-Assisted Tissue-Healing Therapies

Total Page:16

File Type:pdf, Size:1020Kb

Bioactive Glasses: from Parent 45S5 Composition to Scaffold-Assisted Tissue-Healing Therapies Journal of Functional Biomaterials Review Bioactive Glasses: From Parent 45S5 Composition to Scaffold-Assisted Tissue-Healing Therapies Elisa Fiume, Jacopo Barberi, Enrica Verné * and Francesco Baino * ID Institute of Materials Physics and Engineering, Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy; elisa.fi[email protected] (E.F.); [email protected] (J.B.) * Correspondence: [email protected] (E.V.); [email protected] (F.B.); Tel.: +39-011-090-4717 (E.V.); +39-011-090-4668 (F.B.) Received: 19 February 2018; Accepted: 13 March 2018; Published: 16 March 2018 Abstract: Nowadays, bioactive glasses (BGs) are mainly used to improve and support the healing process of osseous defects deriving from traumatic events, tumor removal, congenital pathologies, implant revisions, or infections. In the past, several approaches have been proposed in the replacement of extensive bone defects, each one with its own advantages and drawbacks. As a result, the need for synthetic bone grafts is still a remarkable clinical challenge since more than 1 million bone-graft surgical operations are annually performed worldwide. Moreover, recent studies show the effectiveness of BGs in the regeneration of soft tissues, too. Often, surgical criteria do not match the engineering ones and, thus, a compromise is required for getting closer to an ideal outcome in terms of good regeneration, mechanical support, and biocompatibility in contact with living tissues. The aim of the present review is providing a general overview of BGs, with particular reference to their use in clinics over the last decades and the latest synthesis/processing methods. Recent advances in the use of BGs in tissue engineering are outlined, where the use of porous scaffolds is gaining growing importance thanks to the new possibilities given by technological progress extended to both manufacturing processes and functionalization techniques. Keywords: Bioglass; scaffold; tissue engineering; glass-ceramic; silicate glass; borate glass; phosphate glass; mesoporous bioactive glass; sol–gel; drug release 1. Introduction The need for replacing damaged parts of the body in order to restore their physiological functionality has always been the driving force which has supported research into the discovery and the design of new materials able to perform this task as efficiently as possible. After a preliminary definition of biomaterial in the 1950s, mainly based on the criterion of maximum biochemical and biological inertness in contact with body fluids (first-generation materials) [1], the discovery of Bioglass® by Larry L. Hench in 1969 [2] constituted—for the first time in the story of biomaterials—an alternative, extending the concept of biocompatibility to all those materials which were able to promote a positive response of the living system through the formation of a strong tissue–implant bond (second-generation materials) and the genetic activation of specific cell pathways (third-generation smart materials) [3]. Actually, Bioglass® represents the first example of a biomaterial belonging to the third generation, because of the biological role played by its ionic dissolution products, directly released in the physiological environment [4], as well as its capability to strongly bond the host tissue (primarily bone) with the formation of an interfacial calcium phosphate layer [5,6]. Over the last 50 years, numerous studies have been conducted [7,8] to optimize the response of the body to BGs and extend their use to a wider range of specific clinical applications. J. Funct. Biomater. 2018, 9, 24; doi:10.3390/jfb9010024 www.mdpi.com/journal/jfb J. Funct. Biomater. 2018, 9, x FOR PEER REVIEW 2 of 33 J. Funct. Biomater. 2018, 9, 24 2 of 33 Most of this research aimed to define in an exhaustive and satisfactory manner the peculiar featuresMost of ofthe this material research and, aimed in particular, to define its in ability an exhaustive to create and a strong satisfactory bond at manner the interface the peculiar with physiologicalfeatures of the tissues material as well and, as into particular,stimulate tissue its ability healing to createand regeneration. a strong bond at the interface with physiologicalBGs offer tissuesthe possibility as well as of to adjusting stimulate their tissue composition healing and in regeneration. a very flexible manner, conferring specificBGs properties offer the to possibility the material, of adjustingwhich consequent their compositionly becomes in able a very to satisfy flexible requirements manner, conferring both in hardspecific and properties soft-tissue tohealing the material, applications which [9]. consequently becomes able to satisfy requirements both in hardThe and most soft-tissue common healing medical applications products [based9]. on Bioglass® which are available in clinical practice deal withThe mostthe regeneration common medical of calcified products tissues based (e.g on., bone, Bioglass enamel)® which in orthopedics are available and in dentistry clinical practice [10]. dealIn with addition, the regeneration technological of calcified advances tissues in biomaterials (e.g., bone, enamel)production inorthopedics processes made and dentistryit possible, [10 ].in recentIn years, addition, to fabricate technological mechanically advances better-performing in biomaterials 3D production structures processes(scaffolds) made[11,12], it opening possible, upin new recent possibilities years, toin fabricatethe replacement mechanically of bone better-performingtissue also in load-bearing 3D structures sites [13,14]. (scaffolds) [11,12], openingRecent up studies new possibilities have also in highlighted the replacement the ofenormo boneus tissue potential also in load-bearingof BGs in soft sites tissue [13,14 repair]. applicationsRecent [15,16]. studies Promising have also results highlighted were obtained the enormous with regard potential to the ofvascularization BGs in soft tissueprocess repair [17] andapplications nerve regeneration [15,16]. Promising [18], as well results as in were the obtainedformation with of neo-cartilage regard to the [19]. vascularization process [17] andAll nerve these regeneration aspects make [18 ],BGs as wellvery asattractive in the formation in the development of neo-cartilage of TE [ 19and]. regenerative medicine approaches,All these where aspects the makeavailability BGs very of attractivefunctional in arti theficial development in vitro-vascularized of TE and regenerative tissue substitutes medicine is particularlyapproaches, important where the in availability order to guarantee of functional the necessary artificial in nutrients vitro-vascularized and oxygen tissue supply substitutes from the is earliestparticularly days after important the device in order implantation to guarantee [20]. the necessary nutrients and oxygen supply from the earliestGiven days the after extension the device of implantation the topic proposed [20]. in the present review, we have analyzed comprehensivelyGiven the the extension most significant of the topic literature proposed available in in the thepresent field. A Search review, was we conducted have analyzed in the databasecomprehensively SCOPUS theby using most the significant following literature terms as available major keywords: in the field. bioglass, A Search bioactive was conducted glass, scaffold, in the tissuedatabase engineering, SCOPUS bysol–gel, using themesoporous following bioactive terms as majorglass, keywords:composite. bioglass, The present bioactive work glass, provides scaffold, a widetissue overview engineering, on BGs sol–gel, and BG-based mesoporous scaffolds bioactive for TE glass,, thus representing composite. Thea valid present source work of information provides a forwide researchers overview interested on BGs and in BG-based a complete scaffolds and organi for TE,zed thus presentation representing from a valid the sourceearlier ofstages information to the latestfor researchers developments. interested in a complete and organized presentation from the earlier stages to the latest developments. 2. BGs: A Historical Overview 2. BGs: A Historical Overview The discovery of BGs in 1969 is attributed to Larry L. Hench, a Graduate Research Professor in the DepartmentThe discovery of Material of BGs inScience 1969 isand attributed Engineering to Larry at the L. University Hench, a Graduate of Florida Research [21]. Professor in the DepartmentIn order to obtain of Material a material Science able and to Engineeringsurvive exposure at the to University the human of body Florida with [21 ].no formation of a scarIn tissue order around to obtain the aimplanted material abledevice, to survive from 19 exposure69 to 1971, to three the human different body glass with compositions no formation were of a tested,scar tissue on the around basis of the the implanted Na2O–CaO–SiO device,2 fromternary 1969 state to 1971,diagram three shown different in Figure glass compositions1 [2]. were tested, on the basis of the Na2O–CaO–SiO2 ternary state diagram shown in Figure1[2]. FigureFigure 1. 1. CompositionalCompositional diagram diagram for for bone-b bone-bonding.onding. Note Note regions regions A, A, B, B, C, C, D. D. Region Region S Sis is a aregion region of of classclass A A bioactivity bioactivity where where bioactive bioactive glasses glasses (BGs) (BGs) bond bond to to bone bone and and soft soft tissues tissues and and are are gene gene activating. activating. ReproducedReproduced with with permission
Recommended publications
  • Thermal Behaviour and Excess Entropy of Bioactive Glasses and Zn-Doped Glasses
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by HAL-Rennes 1 Thermal behaviour and excess entropy of bioactive glasses and Zn-doped glasses. Eric Wers, Hassane Oudadesse To cite this version: Eric Wers, Hassane Oudadesse. Thermal behaviour and excess entropy of bioactive glasses and Zn-doped glasses.. Journal of Thermal Analysis and Calorimetry, Springer Verlag (Germany), 2013, pp.1-8. <10.1007/s10973-013-3280-3>. <hal-00914284> HAL Id: hal-00914284 https://hal.archives-ouvertes.fr/hal-00914284 Submitted on 5 Dec 2013 HAL is a multi-disciplinary open access L'archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destin´eeau d´ep^otet `ala diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publi´esou non, lished or not. The documents may come from ´emanant des ´etablissements d'enseignement et de teaching and research institutions in France or recherche fran¸caisou ´etrangers,des laboratoires abroad, or from public or private research centers. publics ou priv´es. J Therm Anal Calorim (2013) p: 1–8 DOI 10.1007/s10973-013-3280-3 Thermal behaviour and excess entropy of bioactive glasses and Zn-doped glasses E. Wers, H. Oudadesse ( ✉) Received: 22 March 2013 / Accepted: 4 June 2013 E. Wers, H. Oudadesse ( ✉) SCR, UMR CNRS 6226, University of Rennes 1, 263 av. du Général Leclerc, 35042 Rennes Cedex, France Abstract Bioactive glasses prepared in SiO 2–CaO–Na 2O and P 2O5 system are used as biomaterials in orthopaedic and maxillofacial surgery.
    [Show full text]
  • Journal of Orthodontics and Craniofacial Research
    Journal of Orthodontics and Craniofacial Research Masood H. J Orthod Craniofac Res 2: 109. Research Article DOI: 10.29011/JOCR-109.100109 The Effect of Bioactive Glasses in Air Abrasion Procedures Masood H, Gillam D*, Hill RG Oral Bioengineering, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University, London, UK *Corresponding author: David Gillam, Oral Bioengineering, Institute of Dentistry, Bart’s and the London School of Medicine and Dentistry, Queen Mary University, London, UK Citation: Masood H, Gillam D, Hill RG. (2020) The Effect of Bioactive Glasses in Air Abrasion Procedures. J Orthod Craniofac Res 2: 109. DOI: 10.29011/JOCR-109.100109 Received Date: 14 July 2020; Accepted Date: 24 July 2020; Published Date: 31 July 2020 Abstract Objective: To analyse the effect of particle size and shape of a new bioactive glass BioMinF on air abrasion compared to an air polishing powder (Sylc) using an enamel substitute material (Macor®). Method: The materials used in the study were: 1) Macor, (Precision Ceramics UK) 2) BioMinF: 500gm of glass frit (Cera Dynamics Ltd, UK) and 3) Sylc: Sylc 45S5 glass (Velopex International, UK). An AquaCare Air Abrasion & Polishing System (Velopex) with a hand piece with a 0.8 mm diameter tip was used with a 2mm thick Macor sheet with a feed rate of 1 and an air pressure of 2 bar. The BioMinF glass was milled for 45 seconds in five batches each containing 100 gm of BioMinF frit using a milling machine (Gy-Ro Mill, Glen Creston, and London). The angular particles produced were separated using different sieves to produce <38 micron, 38-63 microns, 63-80 microns, 80-125 microns and 125-250 microns particle size(s) respectively.
    [Show full text]
  • Metal Oxide Nanostructures and Their Applications (ISBN 1-58883-170-1)
    Metal Oxide Nanostructures and their Applications (ISBN 1-58883-170-1) Edited by Ahmad Umar, Najran University, Saudi Arabia Yoon-Bong Hahn, Chonbuk National University, South Korea. Published by American Scientific Publishers, CA, USA, (http://www.aspbs.com/mona/) October 2009 5-Volume Set, 4,000 pages, Hardcover Volume 4 Applications (Part-2) Chapter 13 Bioactive Bioceramic Coatings. Part II: Coatings on Metallic Biomaterials (Vol.4, pp 479-509) Proof-reading Corrections: No. Original Correction 1. Reference [39] 39. A. K. Lynn and D. L. DuQuesnay, Biomaterials 23, 1947 (2002). 2. Reference [97] 97. M. Wei, A. J. Ruys, B. K. Milthorpe, C. C. Sorrell, and J. H. Evans, J. Sol–Gel Sci. Techn. 21, 39 (2001). 3. Figure 6b ⊕ PO ∇ CO Titania 4 3 48 h ⊕ ∇ ⊕ ⊕ ∇∇ ⊕ ⊕ ⊕ ⊕ ⊕ ∇ 24 h ∇ ⊕⊕ Reflectance /arb. units /arb. Reflectance 0 h 2000 1600 1200 800 400 Wavelength /cm-1 CHAPTER 13 Bioactive Bioceramic Coatings: Part II. Coatings on Metallic Biomaterials Jin-Ming Wu1,Min Wang 2 1Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China 2Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong CONTENTS 1. Introduction ..................................... 2 2. Bioactive Bioceramic Coatings ....................... 2 2.1. Physical Deposition ........................... 2 2.2. Sol–Gel Process .............................. 5 2.3. Electrocrystallization, Electrophoretic Deposition, and Electrostatic Spray Deposition ................ 6 2.4. Biomimetic Process ........................... 7 2.5. Other Coating Techniques ..................... 10 3. Nanostructured Titania for In Vitro Apatite Deposition .... 10 3.1. Coating Approaches ......................... 11 3.2. Chemical Modification Approaches .............. 14 4. Composite Coatings .............................. 20 4.1. Ceramic/Metal Composite Coatings ............. 20 4.2.
    [Show full text]
  • Glass Ionomer Bone Cements Based on Magnesium-Containing Bioactive
    Biomed. Glasses 2019; 5:1–12 Research Article Roland Wetzel, Leena Hupa, and Delia S. Brauer* Glass ionomer bone cements based on magnesium-containing bioactive glasses https://doi.org/10.1515/bglass-2019-0001 Received Sep 25, 2018; revised Dec 16, 2018; accepted Jan 14, 2019 1 Introduction Abstract: Glass ionomer cements (GIC) are used in restora- Cements for prosthetic stabilisation or spinal corrective tive dentistry and their properties (low heat during setting, surgeries (vertebroplasty, kyphoplasty) typically consist adhesion to mineralised tissue and surgical metals) make of polymethylmethacrylate [1, 2]. They exhibit a number them of great interest for bone applications. However, den- of drawbacks which include high curing temperatures tal GIC are based on aluminium-containing glasses, and or the presence of unreacted and toxic methacrylic acid the resulting release of aluminium ions from the cements monomers. They also do not bind to bone and are held in needs to be avoided for applications as bone cements. Re- place by mechanical interlocking only [2–6]. As a result, placing aluminium ions in glasses for use in glass ionomer there is a demand for alternative non-toxic cements with cements is challenging, as aluminium ions play a critical bone bonding capability. role in the required glass degradation by acid attack as Glass ionomer cements (GIC) have been used in well as in GIC mechanical stability. Magnesium ions have restorative dentistry as filler or luting materials for been used as an alternative for aluminium in the glass decades [7, 8]. They are formed by an acid-base reaction component, but so far no systematic study has looked into between a polymeric acid and an acid-degradable fluoro- the actual role of magnesium ions.
    [Show full text]
  • Celebrating 100 Years
    AMERICANa CERAMICting SOCIETY ars Celebr 100 ye bullemerginge ceramicstin & glass technology SEPTEMBER 2021 Laser-driven chemical vapor deposition for high-performance fibers and powders New issue inside: SEPTEMBER 2021 • VOLUME 2 • ISSUE 3 www.ceramics.org/ceramicandglassmanufacturing THE VALUE OF COLLABORATION: PARTNERSHIPS ARE A PATH TO SUCCESS ABET ENSURES QUALITY IN UNIVERSITY ENGINEERING EDUCATION ACerS Awards of 2021 | Coe College glass research | Big science in aerospace When it Comes to Heat, We Sweat the Details! Your firing needs are unique. Our laboratory can run tests to So why use an “off the shelf” help identify your process kiln in your process? boundaries. Through our toll firing facility, we can At Harrop, we get it. help to further define That’s why, for over a the equipment/ century, we’ve been processing putting in the hard work combination that to design and service works best for your custom kilns. Is it harder material. And if you to do things this way? are not ready for a Yes. Is the extra effort new kiln, we can toll worth it? You bet! fire your material to help meet your At Harrop, we don’t production needs. stop there. If you aren’t sure what you Does your current need, we can help. kiln company sweat the details? www.harropusa.com 1.614.231.3621 Harrop Ad Sweat the Details ACerS Full Size w 100 logo.indd 1 5/21/20 9:33 AM contents September 2021 • Vol. 100 No.7 feature articles department Announcing ACerS Awards of 2021 News & Trends . 3 29 The Society will honor members and corporations at the Spotlight .
    [Show full text]
  • The Beneficial Mechanical and Biological Outcomes of Thin Copper-Gallium Doped Silica-Rich Bio-Active Glass Implant-Type Coatings
    coatings Article The Beneficial Mechanical and Biological Outcomes of Thin Copper-Gallium Doped Silica-Rich Bio-Active Glass Implant-Type Coatings George E. Stan 1,* , Teddy Tite 1, Adrian-Claudiu Popa 1, Iuliana Maria Chirica 1, Catalin C. Negrila 1, Cristina Besleaga 1 , Irina Zgura 1, Any Cristina Sergentu 1, Gianina Popescu-Pelin 2 , Daniel Cristea 3, Lucia E. Ionescu 4, Marius Necsulescu 4 , Hugo R. Fernandes 5 and José M. F. Ferreira 5 1 National Institute for Materials Physics, RO-077125 Magurele, Romania; teddy.tite@infim.ro (T.T.); [email protected] (A.-C.P.); iuliana.bogdan@infim.ro (I.M.C.); catalin.negrila@infim.ro (C.C.N.); cristina.besleaga@infim.ro (C.B.); irina.zgura@infim.ro (I.Z.); [email protected] (A.C.S.) 2 National Institute for Lasers, Plasma and Radiation Physics, RO-077125 Magurele, Romania; gianina.popescu@inflpr.ro 3 Faculty of Materials Science and Engineering, Transilvania University of Brasov, 500068 Brasov, Romania; [email protected] 4 Army Centre for Medical Research, RO-020012 Bucharest, Romania; [email protected] (L.E.I.); [email protected] (M.N.) 5 Department of Materials and Ceramics Engineering, CICECO, University of Aveiro, 3810-193 Aveiro, Portugal; [email protected] (H.R.F.); [email protected] (J.M.F.F.) * Correspondence: george_stan@infim.ro; Tel.: +40-21-241-8128 Received: 12 October 2020; Accepted: 18 November 2020; Published: 20 November 2020 Abstract: Silica-based bioactive glasses (SBG) hold great promise as bio-functional coatings of metallic endo-osseous implants, due to their osteoproductive potential, and, in the case of designed formulations, suitable mechanical properties and antibacterial efficacy.
    [Show full text]
  • The Effects of Copper Addition on the Structure and Antibacterial
    bioRxiv preprint doi: https://doi.org/10.1101/2020.01.24.918524; this version posted January 25, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. The Effects of Copper Addition on The Structure and Antibacterial Properties of Biomedical Glasses Leyla Mojtabavi1, Amir Razavi1* 1University of Tehran, Department of Engineering Science, Enghelab Ave, Tehran, Iran 111554563 Address for Correspondence: Department of Engineering Science, University of Tehran, Enghelab Ave, Tehran, Iran 111554563 Tel: +989147560142 Email: [email protected] This study was conducted to determine the effects that copper (Cu) has on the glass structure and antibacterial efficacy of a SiO2- CaO-Na2O-P2O5 bioactive glass composition. Copper is known to be an antibacterial agent, which could potentially be a safer alternative to doping materials with antibiotics. Additionally, the structural effects of copper in the glass were studied, as the glass structure plays an important role in its bioactivity in the physiological solutions. This leads to the possibility of achieving antibacterial glass that can serve as a bioactive glass for skeletal tissue. bioRxiv preprint doi: https://doi.org/10.1101/2020.01.24.918524; this version posted January 25, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license.
    [Show full text]
  • Lecture #16 Glass-Ceramics: Nature, Properties and Processing Edgar Dutra Zanotto Federal University of São Carlos, Brazil [email protected] Spring 2015
    Glass Processing Lecture #16 Glass-ceramics: Nature, properties and processing Edgar Dutra Zanotto Federal University of São Carlos, Brazil [email protected] Spring 2015 Lectures available at: www.lehigh.edu/imi Sponsored by US National Science Foundation (DMR-0844014) 1 Glass-ceramics: nature, applications and processing (2.5 h) 1- High temperature reactions, melting, homogeneization and fining 2- Glass forming: previous lectures 3- Glass-ceramics: definition & applications (March 19) Today, March 24: 4- Composition and properties - examples 5- Thermal treatments – Sintering (of glass powder compactd) or -Controlled nucleation and growth in the glass bulk 6- Micro and nano structure development April 16 7- Sophisticated processing techniques 8- GC types and applications 9- Concluding remmarks 2 Review of Lecture 15 Glass-ceramics -Definition -History -Nature, main characteristics -Statistics on papers / patents - Properties, thermal treatments micro/ nanostructure design 3 Reading assignments E. D. Zanotto – Am. Ceram. Soc. Bull., October 2010 Zanotto 4 The discovery of GC Natural glass-ceramics, such as some types of obsidian “always” existed. René F. Réaumur – 1739 “porcelain” experiments… In 1953, Stanley D. Stookey, then a young researcher at Corning Glass Works, USA, made a serendipitous discovery ...… 5 <rms> 1nm Zanotto 6 Transparent GC for domestic uses Zanotto 7 Company Products Crystal type Applications Photosensitive and etched patterned Foturan® Lithium-silicate materials SCHOTT, Zerodur® β-quartz ss Telescope mirrors Germany
    [Show full text]
  • Injectable Bioactive Glass in the Restoration of Oral Bone Defect
    European Review for Medical and Pharmacological Sciences 2016; 20: 1665-1668 Injectable bioactive glass in the restoration of oral bone defect C.-B. HAN, S.-C. AN Department of Oral and Maxillofacial Surgery, Weifang People’s Hospital, Weifang, Shandong, China Abstract. – OBJECTIVE: To explore the appli- the optimal graft material, but these materials had cation value of injectable bioactive glass in the some limitations2. The injectable bioactive glass had restoration of the oral bone defect. good bioactivity and biocompatibility, ion exchange PATIENTS AND METHODS: This study includ- that occurred between the bioactive glass and soft ed 58 consecutive patients with oral bone defect > 1 mm, these patients were randomly assigned tissue as well as bone may be directly involved in to a control group (n=26, Hydroxyapatite bioce- the metabolism and restoration of human bone tis- ramics) and an observation group (n=32, Inject- sue. As a result, identical inorganic mineral, i.e., car- able bioactive glass). The purpose of this study bonated hydroxyapatite could form on the material was to assess the comparison of the healing of surface, inducing growth of new bone tissue3,4. Most oral bone defect. previous studies explored the application value of RESULTS: X-ray examination was performed at 5,6 6-month and 12-month following treatment. The bioactive glass through animal models , while this bone healing in the observation group was sig- study would further confirm the value of bioactive nificantly better than the control group (p <0.05), glass through clinical controlled trial in humans. the incidences of local rejection reactions were not significantly different (p >0.05).
    [Show full text]
  • Current Progress in Solution Precursor Plasma Spraying of Cermets: a Review
    metals Review Current Progress in Solution Precursor Plasma Spraying of Cermets: A Review Romnick Unabia 1,2,*, Rolando Candidato Jr. 1 and Lech Pawłowski 2 ID 1 Physics Department, College of Science and Mathematics, MSU-Iligan Institute of Technology, Iligan City 9200, Philippines; [email protected] 2 IRCER UMR 7315 CNRS, University of Limoges, Limoges Cedex 87068, France; [email protected] * Correspondence: [email protected]; Tel.: +33-0-587-502-400 Received: 1 May 2018; Accepted: 1 June 2018; Published: 4 June 2018 Abstract: Ceramic and metal composites, known also as cermets, may considerably improve many material properties with regards to that of initial components. Hence, cermets are frequently applied in many technological fields. Among many processes which can be employed for cermet manufacturing, thermal spraying is one of the most frequently used. Conventional plasma spraying of powders is a popular and cost-effective manufacturing process. One of its most recent innovations, called solution precursor plasma spraying (SPPS), is an emerging coating deposition method which uses homogeneously mixed solution precursors as a feedstock. The technique enables a single-step deposition avoiding the powder preparation procedures. The nanostructured coatings developed by SPPS increasingly find a place in the field of surface engineering. The present review shows the recent progress in the fabrication of cermets using SPPS. The influence of starting solution precursors, such as their chemistry, concentration, and solvents used, to the micro-structural characteristics of cermet coatings is discussed. The effect of the operational plasma spray process parameters such as solution injection mode to the deposition process and coatings’ microstructure is also presented.
    [Show full text]
  • The Effect of Dentine Pre-Treatment Using Bioglass And/Or Polyacrylic
    Journal of Dentistry 73 (2018) 32–39 Contents lists available at ScienceDirect Journal of Dentistry journal homepage: www.elsevier.com/locate/jdent The effect of dentine pre-treatment using bioglass and/or polyacrylic acid on T the interfacial characteristics of resin-modified glass ionomer cements ⁎ Salvatore Sauroa,b, , Timothy Watsonb, Agustin Pascual Moscardóc, Arlinda Luzia, Victor Pinheiro Feitosad, Avijit Banerjeeb,e a Dental Biomaterials, Preventive & Minimally Invasive Dentistry, Departamento de Odontologia, CEU Carndenal Herrera University, Valencia, Spain b Tissue Engineering and Biophotonics Research Division, King’s College London Dental Institute, King’s College London, United Kingdom c Departamento de Odontologia, Universitat de Valencia, Valencia, Spain d Paulo Picanço School of Dentistry, Fortaleza, Ceará, Brazil e Department of Conservative & MI Dentistry, King’s College London Dental Institute, King’s College London, United Kingdom ARTICLE INFO ABSTRACT Keywords: Objective: To evaluate the effect of load-cycle aging and/or 6 months artificial saliva (AS) storage on bond Air-abrasion durability and interfacial ultramorphology of resin-modified glass ionomer cement (RMGIC) applied onto den- Bioactive glass tine air-abraded using Bioglass 45S5 (BAG) with/without polyacrylic acid (PAA) conditioning. Bonding Methods: RMGIC (Ionolux, VOCO) was applied onto human dentine specimens prepared with silicon-carbide Dentine pre-treatment abrasive paper or air-abraded with BAG with or without the use of PAA conditioning. Half of bonded-teeth were Polyacrylic acid submitted to load cycling (150,000 cycles) and half immersed in deionised water for 24 h. They were cut into Resin-modified glass ionomer cements matchsticks and submitted immediately to microtensile bond strength (μTBS) testing or 6 months in AS im- mersion and subsequently μTBS tested.
    [Show full text]
  • Silicon Nitride, a Close to Ideal Ceramic Material for Medical Application
    ceramics Review Silicon Nitride, a Close to Ideal Ceramic Material for Medical Application Robert B. Heimann Am Stadtpark 2A, D-02826 Görlitz, Germany; [email protected]; Tel.: +49-3581-667851 Abstract: This topical review describes the salient results of recent research on silicon nitride, a ceramic material with unique properties. The outcome of this ongoing research strongly encourages the use of monolithic silicon nitride and coatings as contemporary and future biomaterial for a variety of medical applications. Crystallographic structure, the synthesis and processing of monolithic structures and coatings, as well as examples of their medical applications that relate to spinal, orthopedic and dental implants, bone grafts and scaffolds, platforms for intelligent synthetic neural circuits, antibacterial and antiviral particles and coatings, optical biosensors, and nano-photonic waveguides for sophisticated medical diagnostic devices are all covered in the research reviewed herein. The examples provided convincingly show that silicon nitride is destined to become a leader to replace titanium and other entrenched biomaterials in many fields of medicine. Keywords: silicon nitride; structure; properties; processing; coatings; spinal implants; arthroplastic implants; bone scaffolds; dental implants; neural circuits; biosensors; medical diagnostics Citation: Heimann, R.B. Silicon 1. Introduction Nitride, a Close to Ideal Ceramic Material for Medical Application. Today, the research and development of metallic, ceramic, polymeric and composite Ceramics 2021, 4, 208–223. biomaterials have progressed to a high level of involvement and sophistication. This is https://doi.org/10.3390/ related to the fact that an ever-increasing part of the world population is in need of the repair ceramics4020016 or replacement of dysfunctional or damaged parts of the body, such as dental roots and teeth, alveolar ridge augmentation, intraocular lenses, heart pacemakers, cochlear implants, Academic Editors: Stuart Hampshire and hip and knee endoprostheses [1].
    [Show full text]