Halo Wars 2 Awakening the Nightmare
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Weighing the Trade-Offs of a Direct Presence in Japan's Rare And
Special Report Weighing the Trade-offs of a Direct Presence in Japan’s Rare and Orphan Drug Market January 2020 Contents Summary ................................................................2 Background on increasing interest in Japan among rare and orphan biopharma companies ....................3 Attractive market fundamentals at the heart of the opportunity ............................................................4 Retaining control helps avoid poor partnering outcomes and entanglements ..................................6 The market is not without its challenges ...................7 A direct presence will not make business sense for everyone ............................................................. 10 Checklist for prospective Japan entrants ................. 11 Endnotes/About the Authors ................................. 12 About L.E.K. Consulting L.E.K. Consulting is a global management consulting firm that uses deep industry expertise and rigorous analysis to help business leaders achieve practical results with real impact. We are uncompromising in our approach to helping clients consistently make better decisions and deliver improved performance. The firm advises and supports organizations that are leaders in their sectors, including the largest private and public sector organizations, private equity firms, and emerging entrepreneurial businesses. Founded in 1983, L.E.K. employs more than 1,600 professionals across the Americas, Asia-Pacific and Europe. For more information, go to www.lek.com. 1 Summary Japan has long sought to foster an attractive market for orphan you consider the benefits of avoiding entanglement with a drugs, with specific provisions made to encourage the development partner and the challenges of managing relationships with of therapies for rare and orphan diseases as early as 1972.1 The potential licensing partners. measures and incentives that followed made the orphan and rare • But setting up a direct presence in Japan is not for model economically viable in Japan, yet companies operating in everyone. -
2006 2012 2013 2014 Introducing HALO® 2 Fused-Core®
Introducing HALO® 2 Fused-Core® UHPLC Columns From Advanced Materials Technology Rugged ∙ High Efficiency ∙ Low Back Pressure HALO 2 Fused-Core particles are designed to address the disadvantages inherent in existing sub-2 micron non-core UHPLC columns. HALO 2 UHPLC columns have all of the advantages of sub-2 µm non-core particle columns and will deliver 300,000 plates per meter efficiency (higher than existing non-core sub-2 µm columns). Manufactured with 1.0 µm frits on the column inlet, HALO 2 columns are less susceptible to column plugging. These columns can be used up to 1,000 bar (14,500 psi), but will actually produce ~20% lower back pressure than most commercially available sub-2 µm UHPLC columns under the same conditions. 1 Advantages of HALO 2 Fused-Core Columns vs. Sub-2 µm Non-core UHPLC Columns · Fused-Core UHPLC columns with ~300K plates per meter · All of the advantages of sub-2 µm non-core particles at lower - Higher efficiency than existing non-core sub-2 µm columns operating pressures · Longer column lifetime – more injections, less downtime - High speed and efficiency with short columns - Due to Fused-Core 2 micron particle architecture, 1 micron - Improved productivity from faster analyses frits can be used on the column inlet - Less solvent usage from shorter analysis times - 1 micron frits are less likely to be plugged by UHPLC samples - High resolution and peak capacity in longer columns or mobile phase contaminants than typical 0.2 – 0.5 µm - Sharper, taller peaks = better sensitivity and lower LOD frits on sub-2 -
Game Enforcer Is Just a Group of People Providing You with Information and Telling You About the Latest Games
magazine you will see the coolest ads and Letter from The the most legit info articles you can ever find. Some of the ads include Xbox 360 skins Editor allowing you to customize your precious baby. Another ad is that there is an amazing Ever since I decided to do a magazine I ad on Assassins Creed Brotherhood and an already had an idea in my head and that idea amazing ad on Clash Of Clans. There is is video games. I always loved video games articles on a strategy game called Sid Meiers it gives me something to do it entertains me Civilization 5. My reason for this magazine and it allows me to think and focus on that is to give you fans of this magazine a chance only. Nowadays the best games are the ones to learn more about video games than any online ad can tell you and also its to give you a chance to see the new games coming out or what is starting to be making. Game Enforcer is just a group of people providing you with information and telling you about the latest games. We have great ads that we think you will enjoy and we hope you enjoy them so much you buy them and have fun like so many before. A lot of the games we with the best graphics and action. Everyone likes video games so I thought it would be good to make a magazine on video games. Every person who enjoys video games I expect to buy it and that is my goal get the most sales and the best ratings than any other video game magazine. -
Game Console Rating
Highland Township Public Library - Video Game Collection Updated January 2020 Game Console Rating Abzu PS4, XboxOne E Ace Combat 7: Skies Unknown PS4, XboxOne T AC/DC Rockband Wii T Age of Wonders: Planetfall PS4, XboxOne T All-Stars Battle Royale PS3 T Angry Birds Trilogy PS3 E Animal Crossing, City Folk Wii E Ape Escape 2 PS2 E Ape Escape 3 PS2 E Atari Anthology PS2 E Atelier Ayesha: The Alchemist of Dusk PS3 T Atelier Sophie: Alchemist of the Mysterious Book PS4 T Banjo Kazooie- Nuts and Bolts Xbox 360 E10+ Batman: Arkham Asylum PS3 T Batman: Arkham City PS3 T Batman: Arkham Origins PS3, Xbox 360 16+ Battalion Wars 2 Wii T Battle Chasers: Nightwar PS4, XboxOne T Beyond Good & Evil PS2 T Big Beach Sports Wii E Bit Trip Complete Wii E Bladestorm: The Hundred Years' War PS3, Xbox 360 T Bloodstained Ritual of the Night PS4, XboxOne T Blue Dragon Xbox 360 T Blur PS3, Xbox 360 T Boom Blox Wii E Brave PS3, Xbox 360 E10+ Cabela's Big Game Hunter PS2 T Call of Duty 3 Wii T Captain America, Super Soldier PS3 T Crash Bandicoot N Sane Trilogy PS4 E10+ Crew 2 PS4, XboxOne T Dance Central 3 Xbox 360 T De Blob 2 Xbox 360 E Dead Cells PS4 T Deadly Creatures Wii T Deca Sports 3 Wii E Deformers: Ready at Dawn PS4, XboxOne E10+ Destiny PS3, Xbox 360 T Destiny 2 PS4, XboxOne T Dirt 4 PS4, XboxOne T Dirt Rally 2.0 PS4, XboxOne E Donkey Kong Country Returns Wii E Don't Starve Mega Pack PS4, XboxOne T Dragon Quest 11 PS4 T Highland Township Public Library - Video Game Collection Updated January 2020 Game Console Rating Dragon Quest Builders PS4 E10+ Dragon -
Game Narrative Review
Game Narrative Review ==================== Your name (one name, please): Kai McDonald Your school: DigiPen Institute of Technology Your email: [email protected] Month/Year you submitted this review: December 2019 ==================== Game Title: Halo Reach Platform: Xbox 360 Genre: First-person shooter Release Date: September 14th, 2010 Developer: Bungie Publisher: Microsoft Game Studios Game Writer/Creative Director/Narrative Designer: Marcus Lehto Overview Halo: Reach takes place in the distant future of the year 2552. Technology has progressed far beyond the imaginations of the modern day, and humanity finds itself at war. United under a single banner known as the United Nations Space Command (UNSC), Humans find themselves at odds with a cult of alien races known as the Covenant. Most of humanities’ interstellar colonies have fallen by the opening of the game. Players take on the burden of Noble Six, an elite UNSC super soldier joining the special operations unit known as Noble Team. The team has been tasked with investigating a communication station that has recently gone silent on the part UNSC hub, part human colony planet known as Reach. Thrown into a surprise invasion by the Covenant, the player faces tragedy after tragedy as team members make sacrifices, lose battles, and are subjected to the bleak realities of war. Halo: Reach is not a story of heroism and triumph. 1 It is one of failure, defeat, and most importantly, death. From the beginning, you know the end. Characters ● Noble Team – Composed of genetically enhanced UNSC super-soldiers known as “SPARTANS”, Noble Team served as the answer to UNSC’s hard questions regarding important missions. -
'Halo' TV Series, 'Halo 5' Game Launching in 2015 16 May 2014, by Derrik J
'Halo' TV series, 'Halo 5' game launching in 2015 16 May 2014, by Derrik J. Lang 343 Studio general manager Bonnie Ross noted that additional plans this year for the "Halo" franchise would be announced June 9 at Microsoft's presentation at the Electronic Entertainment Expo, the largest annual gathering of the gaming industry. In this May 21, 2013 file photo, Nancy Tellem, right, the entertainment and digital media president of Microsoft, and Bonnie Ross, left, general manager and studio head of 343 Industries, announce a new Halo live-action TV series for Xbox Live, during an event to unveil the next- generation Xbox One entertainment and gaming console system, in Redmond, Wash. Master Chief is returning to This file photo provided by Microsoft shows a scene from the battlefield next year. Microsoft announced plans the "Halo" video game for the Xbox One. Master Chief is Friday, May 16, 2014, to release the video game sequel returning to the battlefield next year. Microsoft "Halo 5: Guardians" for the Xbox One and a "Halo" announced plans Friday, May 16, 2014, to release the television series to be produced by Steven Spielberg in video game sequel "Halo 5: Guardians" for the Xbox One fall 2015. (AP Photo/Ted S. Warren, file) and a "Halo" television series to be produced by Steven Spielberg in fall 2015. (AP Photo/Microsoft, file) Master Chief is returning to the battlefield next year. © 2014 The Associated Press. All rights reserved. Microsoft announced plans Friday to release the video game sequel "Halo 5: Guardians" for the Xbox One and a "Halo" television series to be produced by Steven Spielberg in fall 2015. -
Intersomatic Awareness in Game Design
The London School of Economics and Political Science Intersomatic Awareness in Game Design Siobhán Thomas A thesis submitted to the Department of Management of the London School of Economics for the degree of Doctor of Philosophy. London, June 2015 1 Declaration I certify that the thesis I have presented for examination for the PhD degree of the London School of Economics and Political Science is solely my own work. The copyright of this thesis rests with the author. Quotation from it is permitted, provided that full acknowledgement is made. This thesis may not be reproduced without my prior written consent. I warrant that this authorisation does not, to the best of my belief, infringe the rights of any third party. I declare that my thesis consists of 66,515 words. 2 Abstract The aim of this qualitative research study was to develop an understanding of the lived experiences of game designers from the particular vantage point of intersomatic awareness. Intersomatic awareness is an interbodily awareness based on the premise that the body of another is always understood through the body of the self. While the term intersomatics is related to intersubjectivity, intercoordination, and intercorporeality it has a specific focus on somatic relationships between lived bodies. This research examined game designers’ body-oriented design practices, finding that within design work the body is a ground of experiential knowledge which is largely untapped. To access this knowledge a hermeneutic methodology was employed. The thesis presents a functional model of intersomatic awareness comprised of four dimensions: sensory ordering, sensory intensification, somatic imprinting, and somatic marking. -
Makers of League of Legends, Halo Video Games Create Designs For
Makers of League of Legends, Halo Video Games Create Designs for Limbitless Solutions’ Arms Future recipients of 3D-printed prosthetic arms from UCF’s Limbitless Solutions will have new designs to choose from beginning in 2019, thanks to the makers of video games League of Legends and Halo. Riot Games, maker of League of Legends, and 343 Industries, maker of Halo and owned by Microsoft Studios, collaborated with Limbitless Solutions to create seven new prosthetic-arm designs inspired by their games. League of Legends is an online game that pits two teams of characters with unique designs, playstyles and capabilities against each other on various battlefields, and Halo is a first-person shooter game that centers on an interstellar war between humanity and aliens. Designs from League of Legends include five inspired by their Odyssey Jinx, Star Guardian, Shurima, Illaoi and Maokai characters and worlds, and two from Halo, inspired by different armor suits of Master Chief. The designs are in the form of interchangeable sleeves that attach to the prosthetic device via magnets to allow the children to swap out for different designs as they please. “It is so exciting to be able to add these new designs to the catalog for children to customize their arms,” said Albert Manero, CEO and co-founder of Limbitless Solutions. “It will unlock new expression and confidence for children, and we are so grateful for the opportunity to collaborate with these companies’ design teams.” The collaboration with Riot spawned from an employee’s desire to support Limbitless and UCF, his alma mater. -
Score Pause Game Settings Fire Weapon Reload/Action Switch Weapo
Fire Weapon Reload/Action ONLINE ENABLED Switch Weapons Melee Attack Jump Swap Grenades Flashlight Zoom Scope (Click) Throw Grenade E-brake (Warthog) Boost (Vehicles) Crouch (Click) Score Pause Game Settings Get the strategy guide primagames.com® ® 0904 Part No. X10-96235 SAFETY INFORMATION TABLE OF CONTENTS About Photosensitive Seizures Secret Transmission ........................................................................................... 2 A very small percentage of people may experience a seizure when exposed to certain visual images, including flashing lights or patterns that may appear in video games. Even people who Master Chief .......................................................................................................... 3 have no history of seizures or epilepsy may have an undiagnosed condition that can cause these Breakdown of Known Covenant Units ......................................................... 4 “photosensitive epileptic seizures” while watching video games. These seizures may have a variety of symptoms, including lightheadedness, altered vision, eye or Controller ............................................................................................................... 6 face twitching, jerking or shaking of arms or legs, disorientation, confusion, or momentary loss of awareness. Seizures may also cause loss of consciousness or convulsions that can lead to injury from Mjolnir Mark VI Battle Suit HUD ..................................................................... 8 falling down or striking -
Halo Legendary Edition Overview of Components Cont
2-5 AGES 10+ PLAYERS RISK: HALO LEGENDARY EDITION OVERVIEW OF COMPONENTS CONT. “In a distant corner of the galaxy a new Halo ring, one of the ancient superweapons of the mysterious Forerunner civilization is found and the battle sparks anew: Brave Humanity, battling for survival and DICE discovery against the discipline and zealotry of the Covenant alliance of alien species who worship the long-absent Forerunners...and looming terrifying above both of these factions is the parasitic You use the dice when attacking and defending territories. Flood infection which threatens to corrupt all living creatures into mindless creatures of violence ( see ATTACKING, pg.10) and rage. Which faction will triumph in this legendary new front in the battle for the Halo universe? ATTACK DICE DEFENSE DICE That, players, is up to you...” MOBILE TELEPORTERS Pairs of Mobile Teleporters will be placed on the board onto different OVERVIEW OF COMPONENTS territories. These connect two previously separated territories. Forces can maneuver and attack normally via these Mobile Teleporters. (see USING Mobile Teleporters, pg. 8 for further explanation) WHAT’S INSIDE UNITS CONTENTS Every player will control a faction of one color. • 4 Battlefields • 2 UNSC Factions* • 22 Campaign cards Heroes • 2 Double-sided Game Boards • 2 COVENANT Factions** • 44 Faction cards Heroes possess elite skills in both attack • 10 Mobile Teleporters • 1 FLOOD Faction*** • 5 Bases and defense that can turn the tide of battle. • 5 Dice *UNSC - 1 spartan, 1 firebase, 36 marines, 18 tanks ( see ATTACKING, pg. 10 for further explanation) **Covenant - 1 aribiter, 1 command center, 36 grunts, 18 wraiths UNSC COVENANT FLOOD ***Flood - 1 thasher, 1 proto-gravemind, 36 infection forms and 18 carrier forms Not all components are used in every game mode. -
Warthog) Boost (Vehicles)
Fire Weapon Reload/Action ONLINE ENABLED Switch Weapons Melee Attack Jump Swap Grenades Active Camo Zoom Scope (Click) Throw Grenade E-brake (Warthog) Boost (Vehicles) Crouch (Click) Score Pause Game Settings Get the strategy guide ™ primagames.com® 0904 Part No. X10-62678 SAFETY INFORMATION TABLE OF CONTENTS About Photosensitive Seizures Report on the Atrocity at Halo ........................................................................ 2 A very small percentage of people may experience a seizure when exposed to certain visual Updated Intelligence on Human Weapons and Tactics ........................ 3 images, including flashing lights or patterns that may appear in video games. Even people who have no history of seizures or epilepsy may have an undiagnosed condition that can cause these Our Numbers Deployed on the Human World ......................................... 4 “photosensitive epileptic seizures” while watching video games. These seizures may have a variety of symptoms, including lightheadedness, altered vision, eye or Controller ............................................................................................................... 6 face twitching, jerking or shaking of arms or legs, disorientation, confusion, or momentary loss of Sangheili Battle Suit ........................................................................................... 8 awareness. Seizures may also cause loss of consciousness or convulsions that can lead to injury from falling down or striking nearby objects. Battle Tactics ......................................................................................................... -
UNSC Science and Technology Command
UNSC Science and Technology Command Earth Survey Catalogue: Official Name/(Common) Star System Distance Coordinates Remarks/Status 18 Scorpii {TCP:p351} 18 Scorpii {Fact} 45.7 LY 16h 15m 37s Diameter: 1,654,100km (1.02R*) {Fact} -08° 22' 06" {Fact} Spectral Class: G2 Va {Fact} Surface Temp.: 5,800K {Fact} 18 Scorpii ?? (Falaknuma) 18 Scorpii {Fact} 45.7 LY 16h 15m 37s UNSC HQ base on world. UNSC {TCP:p351} {Fact} -08° 22' 06" recruitment center in the city of Halkia. {TCP:p355} Constellation: Scorpio 111 Tauri 111 Tauri {Fact} 47.8 LY 05h:24m:25.46s Diameter: 1,654,100km (1.19R*) {Fact} +17° 23' 00.72" {Fact} Spectral Class: F8 V {Fact} Surface Temp.: 6,200K {Fact} Constellation: Taurus 111 Tauri ?? (Victoria) 111 Tauri {Fact} 47.8 LY 05:24:25.4634 UNSC colony. {GoO:p31} {Fact} +17° 23' 00.72" Constellation: Taurus Location of a rebel cell at Camp New Hope in 2531. {GoO:p31} 51 Pegasi {Fact} 51 Pegasi {Fact} 50.1 LY 22h:57m:28s Diameter: 1,668,000km (1.2R*) {Fact} +20° 46' 7.8" {Fact} Spectral Class: G4 (yellow- orange) {Fact} Surface Temp.: Constellation: Pegasus 51 Pegasi-B (Bellerophon) 51 Pegasi 50.1 LY 22h:57m:28s Gas giant planet in the 51 Pegasi {Fact} +20° 46' 7.8" system informally named Bellerophon. Diameter: 196,000km. {Fact} Located on the edge of UNSC territory. {GoO:p15} Its moon, Pegasi Delta, contained a Covenant deuterium/tritium refinery destroyed by covert UNSC forces in 2545. {GoO:p13} Constellation: Pegasus 51 Pegasi-B-1 (Pegasi 51 Pegasi 50.1 LY 22h:57m:28s Moon of the gas giant planet 51 Delta) {GoO:p13} +20° 46' 7.8" Pegasi-B in the 51 Pegasi star Constellation: Pegasus system; a Covenant stronghold on the edge of UNSC territory.