Place: Hotel 525. C/ del Río Borines 58. Los Alcázares, Murcia. . Duration: 30 hours. Actividades y Cursos de Verano Max enrollment: 100 students. 35ª edición 2018 Prize: 160 € (Lunch included).

REGISTRATION RULES CREDIT RECOGNITION Please complete the Registration Form at the offi- This course enables you to obtain elective credits at CELL THERAPY cial website:https://www.um.es/unimar Payment the Universidad of Murcia, in accordance with the Uni- Methods: Credit Card (Website) Cash – only in per- versity’s academic regulations. Students registered at son: Download the Payment form. other universities must provide the Credit Recognition FROM THE BENCH Fill in the form and return it with your payment to requirements for transfer of credit toward their degree Universidad Internacional del Mar. Banks: Banco program at their home university (certificate, diploma, Sabadell, Bankia, Cajamar and Banco Santander. program…) . TO THE BEDSIDE Once payment is made you will be enrolled in the course. Students must be enrolled and have a re- The Course has been declared of Scientific and Medi- gular attendance to obtain the diploma or its equi- cal Interest by the Public Health System of Murcia. AND RETURN valent. UNIVERSIDAD INTERNACIONAL DEL MAR Edificio Luis Vives, 3ª Planta 30100 Campus de Espinardo, Murcia Sumary Target Group T. 868 88 8207 / 7262 / 3376 / 3360 / 3359 Stem cells whether at the embryonic or indu- Los Alcázares Hematologists and other medicine doctors, biome- [email protected] ced pluripotent adult, are a potentially unlimited dical researchers, students, graduates and others Del 2 al 6 de julio source of cells for research or for clinical use interested in the subject. in transplantation. The enormous impact of re- search on the use of stem cells in medicine have Directors been in the media has contributed to high expec- Prof. José María Moraleda Jiménez. Professor of www.um.es/unimar tations in the immediate development of modern Medicine. . Head Dpt of Hematology and therapies for the improvement or repair of cell HSCT Program. Institute of Biomedical Research of Murcia UNIVERSIDAD DE MURCIA function. - IMIB, Virgen de la Arrixaca University Hospital. Murcia, VICERRECTORADO DE EMPLEO, EMPRENDIMIENTO Y SOCIEDAD In the last five years, few issues have generated Spain. biomedicine increased interest in the company, Prof. Damián García Olmo. Professor of Surgery. Chief Directors with unresolved debates on different aspects of of Department of Surgery. Fundación Jiménez Díaz University Patrocina Colabora Prof. José María Moraleda Jiménez Hospital. Autonomous University of Madrid. Madrid, Spain. both stem cell research and its clinical use. It Prof. Damián García Olmo therefore seems very appropriate to organize a Prof. Robert Sackstein. Professor and Director of the Prof. Robert Sackstein Program of Excellence in Glycoscience, Harvard Medical School, forum for expanding knowledge of this cell type, Prof. Salvador Martínez Pérez biology, techniques for handling in the laboratory Boston. MA, USA. and, above all of its current and future therapeu- Prof. Salvador Martínez Pérez. Director Institute of tic options, with scientific experts in basic scien- Neurosciences. UMH-CSIC. Professor of Human Anatomy ce and clinical. This will lead to an objective and and Embryology. University Miguel Hernández. Elche, Spain. useful information for attendees Do we need the umbilical cord banks? 15:30 h. Debate session: CAR T- cells and Inmunotherapy. Affor- 12:00 h. Genetical manipulation of MSC to improve function. 11:30 h. Cell Therapy and Microvesicles for Treatment of Transplant 11:00 h. Cell Therapy for Amyotrophic Lateral Sclerosis. Where we Monday 2 Prof. Rafael Duarte. Head Clinical Hematology. University Hos- dability of the new drugs and its economic impact in the Prof. Rosa María Yañez González. Hematopoietic Innovative The- Rejection and GVHD. stand and where we go. BONE MARROW STEM CELLS. HEMATOPOIETIC STEM CELL pital Puerta de Hierro. Madrid, Spain. national health system. rapies Division. CIEMAT. University of Madrid. Madrid, Spain. Prof. Fermín Sánchez-Guijo. Hematology Department. Prof. Letizia Mazzini. Head of the tertiary ALS Center. Depart- TRANSPLANTATION. Should I bank my baby´s cord blood? Chair: Prof. Jorge Sierra. President of Spanish Hematology 12:30 h. Genetically modified MSC to improve function. Animal University Hospital of Salamanca. . ment of Neurology, Eastern Piedmont University, Maggiore Prof. Alejandro Madrigal. Chair of Hematology. The Royal Society. Professor of Medicine . Head models. Salamanca, Spain. della Carità Hospital. Novara, Italy. 09:00 h. Opening Session. Free and University College Medical School. London, UK. Dpt Hematology. University Hospital Santa Creu I Sant Pau. Prof. Mariano García Arranz. Fundación Jiménez Díaz University 12:00 h. Cell Therapy in Odontology. 11:30 h. Gene Therapy: clinical developments. Morning Barcelona, Spain. Hospital. Autonomous University of Madrid. Madrid, Spain. Prof. Francisco J. Rodríguez-Lozano. Professor of Dentis- Prof. Juan Bueren. Head of the Division of Hematopoiesis Session Discussants (10 minutes each and discussion): and Gene Therapy Division CIEMAT. University of Madrid. Chair: Prof. José M. Moraleda. Professor of Medicine. Uni- 13:00 h. Lunch. try. Institute of Biomedical Research of Murcia - IMIB. Vir- Tuesday 3 Prof. Jorge Sierra. Professor of Medicine University of Barce- gen de la Arrixaca University Hospital. University of Murcia. Madrid, Spain. versity of Murcia. Murcia, Spain. lona. Hospital Santa Creu I Sant Pau. Barcelona, Spain. Afternoon 12:00 h. Gene Therapy for Alzheimer disease. IMMUNOTHERAPY AND NEW IMMUNOTHERAPEUTIC APPROACHES Session Murcia, Spain. 09:30 h. The Biology of the Hematopoietic Stem Cell. Prof. Alejandro Madrigal. Chair of Hematology. The Royal Prof. Nathalie Cartier. Research Director. Inserm. Paris, 12:30 h. Lunch. Prof. Carlos Solano Vercet. Head Hematology Dpt. University Morning Free and University College Medical School. London, UK. 15:00 h. iPSC as a Therapeutic Tool. France. Session Clinic Hospital of Valencia. INCLIVA. Professor of Medicine. Prof. Carlos Solano. Head Hematology Dpt. University Clinic Prof. Ángel Raya. Director Center of Regenerative Medicine Afternoon 13:00 h. Lunch Chairs: Prof. José M. Moraleda. Professor of Medicine. Uni- . Valencia, Spain. Hospital of Valencia. INCLIVA. University of Valencia. Valencia, in Barcelona (CMRB). Barcelona, Spain. Session versity of Murcia. Murcia, Spain. Afternoon Spain. 10:00 h. Procurement of Hematopoietic Progenitors: Cellular Selection. Prof. Robert Sackstein. Professor of Glycobiology. Harvard Me- 15:30 h. Fucosylated MSC in the treatment of Inflammation. 14:30 h. Cell Therapy to improve Healing in Surgery. The road map to Session Prof. José Antonio Pérez Simón. (TerCel). Professor of He- Prof. Miguel Blanquer, MD. Hematology Department. Institute dical School, Boston. MA, USA. Prof. David García Bernal. Cell Therapy Unit and HSCT Pro- success. 15:00 h. Debate session: the cell therapy tourism and fraud. Ethical matology. Virgen del Rocío University Hospital. University of of Biomedical Research of Murcia - IMIB, Virgen de la Arrixaca gram. Institute of Biomedical Research of Murcia - IMIB, Vir- Prof. Damián García-Olmo. Professor of Surgery. Chief of and regulatory aspects. 09:00 h. Monoclonal Antibodies. The development of “magic bullets”. Sevilla. Sevila, Spain. University Hospital. University of Murcia. Murcia, Spain. gen de la Arrixaca University Hospital. University of Murcia. Department of Surgery. Fundación Jiménez Díaz University Chairs: Prof. Robert Sackstein. Professor and Director of Bispecific Mo Ab against leukemia. Prof. Felipe Prósper. Director of Cell Therapy Department. Murcia, Spain. Hospital. Autonomous University of Madrid. Madrid, Spain. the Program of Excellence in Glycoscience, Harvard Medical 10:30 h. Coffee break. Prof. Joaquín Martínez López. Head Hematology Dpt. Uni- Co-director Hematology Department. University of Navarra. 16:00 h. Production of cells in GMP facilities: realities and cha- School, Boston. MA, USA. 11:00 h. Hematopoietic cell transplantation: cell therapy to cure versity Hospital 12 de Octubre. Professor of Medicine. Auto- , Spain. 15:15 h. Cell therapy and bioengineering for skin diseases. llenges for the future. Prof. Agustín Zapata. Professor of Cellular Biology. Com- haematological diseases. nomous University of Madrid. Madrid, Spain. Dr. Jorge Gayoso. Medical Associate. National Transplant Prof. Marcela del Río. Professor of Biology. Bioengineering Prof. María Eugenia Fernández-Santos, PhD. Technical Di- plutense University of Madrid. Madrid, Spain. Prof. José M. Moraleda. Professor of Medicine. University Organization (ONT). Madrid, Spain. Dpt. Regenerative Medicine and tissue engineering group, 09:30 h. PD1. A target molecule to revive the immune system against rector of the Cell Production Unit. Gregorio Marañón Univer- Discussants: of Murcia. Head Dpt of Hematology and HSCT Program. Ins- Sol Ruiz, PhD. Head of the Unit of Biotechnology and Advan- CIEMAT, FJD, CIBERER. Carlos III University. Madrid, Spain. Hodgkin´s disease. sity Hospital. Research Institute Gregorio Marañón. Madrid, The opinion of the AEMPS. titute of Biomedical Research of Murcia - IMIB, Virgen de la ced Therapies at EMA. Madrid, Spain. Prof. Ramón García Sanz. Professor of Medicine. University Spain. 16:00 h. Key question conference: “Negotiate in difficult times”. Sol Ruiz, PhD. Head of the Unit of Biotechnology and Advan- Arrixaca University Hospital. Murcia, Spain. Hospital of Salamanca. Salamanca, Spain. Dr Jesús Ángel Loza Aguirre. Ex-Member of the Basque ced Therapies at EMA. Madrid, Spain. 11:30 h. Graft versus host disease. The Jekyl and Hyde of allotran- 09:30 h. CD38. A target molecule to fight against Myeloma. Wednesday 4 Thursday 5 Parliament. Commisioned for coexistence in Euskadi. He- The opinion of the scientists. splantation. Prof. Paula Rodriguez Otero. Hematology Department. Uni- matologist. Prof. Salvador Martínez. MESENCHYMAL STEM CELLS (MSC), INDUCED PLURIPOTENT CELL THERAPY AND TISSUE ENGINEERING. CLINICAL TRIALS Prof. José Antonio Pérez Simón. Professor of Hematology. versity of Navarra. Pamplona, Spain. Prof. Letizia Mazzini. Head Hematology Department. Institute of Biomedicine of Se- STEM CELLS (IPSC), GENE THERAPY: SCIENTIFIC BASIS FOR ITS Morning 10:30 h. Coffee break. villa (IBIS), Virgen del Rocio University Hospital. University of THERAPEUTIC USE. Session Friday 6 16:00 h. Closing ceremony and awarding of certificates. Prof. José M. Moraleda. Sevilla. Sevilla, Spain. Special session on CAR T – cells. Morning Chairs: Professor of Medicine. Uni- 11:00 h. CAR T- cells. Basic principles and clinical Pharmacology. versity of Murcia. Murcia, Spain. CELL THERAPY IN NEUROLOGICAL DISEASES 12:00 h. The immunobiology of Cell therapy and the umbilical cord Session Prof. Irene García Cadenas. Hematology Dpt. Hospital Sant Prof. Damián García-Olmo. Professor of Surgery. Autono- Morning unique cells. Chairs: Prof. José M. Moraleda. Professor of Medicine. Uni- Pau. Institut José Carreras. University of Barcelona. Barce- mous University of Madrid. Madrid, Spain. Session Prof. Alejandro Madrigal. Scientific Director of The Anthony versity of Murcia. Murcia, Spain. lona, Spain. Prof. Robert Sackstein. Professor of Glycobiology. Harvard Me- 09:00 h. Cell Therapy in Cardiac Diseases. Chair: Prof. Salvador Martínez Pérez. Director Institute of Nolan Trust. Chair of Hematology, Department of Hemato- Neurosciences. UMH-CSIC. Professor of Human Anatomy and 11:30 h. CAR T- cells in Leukemia. dical School, Boston. MA, USA. Prof. Felipe Prósper. Director of Cell Therapy Department. Co-di- logy. The Royal Free and University College Medical School. Embryology. University Miguel Hernández. Elche, Spain. Prof. Álvaro Urbano-Ispizua. Director of Hematology and Oncolo- 09:00 h. MSC properties: the biological basis to become a cell me- rector Hematology Department. University of Navarra. Pamplona, London, UK. 09:00 h. Cell replacement therapy for Parkinson´s disease. gy, Hospital Clinic of Barcelona. Institut José Carreras. University dicine. Spain. 13:00 h. Lunch. Prof. José Luis Labandeira. Professor of Anatomy. Neuro- of Barcelona, Barcelona, Spain. Prof. Agustín Zapata. Professor of Cell Biology. Compluten- 09:30 h. Cell Therapy in Diabetes Mellitus. morphology and Experimental Neurology. University of San- Afternoon se University of Madrid. Madrid, Spain. Prof. Bernat Soria. Director of the Stem Cells Department Session 12:00 h. CAR T- cells in Lymphoma. tiago de Compostela. Santiago de Compostela, Spain. Prof Javier Briones Mejide. Hematology Dpt. Hospital Sant 09:30 h. The extrinsic regulation of haematopoietic stem cells as a thera- of the Andalusian Center for Molecular Biology and Rege- Chair: Prof. Robert Sackstein. Professor of Glycobiology. 09:30 h. Antiparkinsonian cell therapy using carotid body cells. Pau. Institut José Carreras. University of Barcelona. Barcelona, peutic target. nerative Medicine (CABIMER). University Pablo de Olavide. Harvard Medical School. Boston, USA. Prof. Juan José Toledo. Professor of Physiology. Director Spain. Prof. Simón Méndez-Ferrer, PhD. Department of Haema- Sevilla, Spain. 15:00 h. Haploidentical transplants. The new frontier. Up to date of the Dpt of Medical Physiology and Biophysics. Institute of tology, NHS-Blood and Transplant. Cambridge Biomedical 10:00 h. Cell Therapy for Osteoarticular Repair. results and new insights. 13:00 h. Lunch. Biomedical Research of Seville. IBiS, Virgen del Rocío Hos- Campus. University of Cambridge. Cambridge, UK. Prof. Javier García-Sancho. Professor of Physiology. School Prof. Rafael Duarte Palomino. Department of Hematology. Afternoon pital/CSIC/University of Sevilla. Sevilla, Spain. Session 10:15 h. Stem cell trafficking. GPS to optimize MSC therapeutics. of Medicine. Institute of Biology and Molecular Genetics University Hospital Puerta de Hierro. Madrid, Spain. 10:00 h. Cell therapy in Friedrich Ataxia a new model of neural re- 15:00 h. CAR T- cells in Mieloma. Prof. Robert Sackstein. Professor and Director of the Pro- (IBGM). . Valladolid, Spain. 15:45 h. Debate session: What is the future of HSCT. Unsolved ques- generation. Prof. Estefanía García Guerrero. Research Scientist. Virgen gram of Excellence in Glycoscience, Harvard Medical School, 10:30 h. Coffee break. tions. Prof. Salvador Martínez. Director Institute of Neurosciences. del Rocío University Hospital. IBIS. University of Sevilla. Se- Boston. MA, USA. Discussants (10 min. each and discussion): 11:00 h. Cell Therapy -Regenerative Medicine- in musculoskeletal UMH-CSIC. Professor of Human Anatomy and Embryology. villa, Spain.. Is the transplant going to survive with the new immunothe- 11:00 h. Coffee break. system. University Miguel Hernández. Elche, Spain. rapies? 11:30 h. Gene editing: A New tool for the future. Prof. Pedro Guillén. Clinical Research Unit, CEMTRO Hos- 10:30 h. Coffee break. Prof. José A Perez Simón. Head Hematology Dpt. University Prof. José Carlos Segovia PhD. Differentiation and Cytome- pital. Madrid, Spain. Hospital Virgen del Rocio. IBIS. Sevilla. Sevilla, Spain. try Unit, Hematopoietic Innovative Therapies Division. CIE- MAT. University of Madrid. Madrid, Spain.