October 24, 2017 u vol. 114 u no. 43

From the Cover

11476 Genetics of canine skeletal abnormalities E9105 Spatial organization of gut 11327 RNA formation in warm little ponds 11416 Enzyme complex–membrane interactions 11518 Local processing in small amacrine cells

Contents

THIS WEEK IN PNAS Cover image: Pictured are a dachshund 11259 In This Issue (Left) and a Nova Scotia duck tolling retriever (Right). Emily A. Brown et al. identified a retrogene insertion of the LETTERS (ONLINE ONLY) FGF4 gene that was associated with shortened limbs in Nova Scotia duck E8945 Efficient large-scale wind turbine deployment can meet global electricity tolling retrievers, and also associated generation needs with short limbs and susceptibility to Jake Badger and Patrick J. H. Volker intervertebral disc disease across E8946 Reply to Badger and Volker: Correctly estimating wind resources at large scales multiple breeds, including requires more than simple extrapolation dachshunds. The results may influence Lee M. Miller and Axel Kleidon treatment of intervertebral disc disease E8947 Simulations predict microbial responses in the environment? This environment in and provide a model for similar disagrees retrospectively conditions in . See the article by Tom O. Delmont and A. Murat Eren Brown et al. on pages 11476–11481. E8950 Reply to Delmont and Eren: Strain variants and population structure during the Image courtesy of Kathryn Robertson Deepwater Horizon (University of California, Davis, CA). oil spill Alexander J. Probst, Ping Hu, Christine L. Sun, Eric A. Dubinsky, Christian M. K. Sieber, Jillian F. Banfield, and Gary L. Andersen E8953 Black-swan events: Population crashes or temporary emigration? Casey Youngflesh and Heather J. Lynch E8955 Reply to Youngflesh and Lynch: Migration and population growth rate in animal black-swan events Sean C. Anderson, Trevor A. Branch, Andrew B. Cooper, and Nicholas K. Dulvy

CORE CONCEPTS—A brief introduction to emerging topics in science 11261 Circumventing the blood–brain barrier Helen H. Shen, Science Writer

COMMENTARIES 11264 Darwin’s prescient guess David Deamer See companion article on page 11327 11266 Lipid sorting and the activity of Arf signaling complexes Yong Zhou and John F. Hancock See companion article on page 11416

Free online through the PNAS open access option. PNAS u October 24, 2017 u vol. 114 u no. 43 u iii–vii Downloaded by guest on September 30, 2021 11268 Compartmentalized dendritic signaling in a EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES multitasking retinal interneuron 11321 Bird specimens track 135 years of atmospheric black Wei Wei carbon and environmental policy See companion article on page 11518 Shane G. DuBay and Carl C. Fuldner 11327 Origin of the RNA world: The fate of nucleobases in PNAS PLUS warm little ponds Ben K. D. Pearce, Ralph E. Pudritz, Dmitry A. Semenov, 11271 Significance Statements and Thomas K. Henning Brief statements written by the authors about the significance of their See Commentary on page 11264 papers. 11333 Formation of most of our coal brought Earth close to global glaciation INAUGURAL ARTICLE Georg Feulner 11275 SMELL-S and SMELL-R: Olfactory tests not influenced ENGINEERING by odor-specific insensitivity or prior 11488 Macrophage-like nanoparticles concurrently absorbing olfactory experience endotoxins and proinflammatory cytokines for Julien W. Hsieh, Andreas Keller, Michele Wong, Rong-San sepsis management Jiang, and Leslie B. Vosshall Soracha Thamphiwatana, Pavimol Angsantikul, Tamara Escajadillo, Qiangzhe Zhang, Joshua Olson, Brian T. Luk, Sophia Zhang, Ronnie H. Fang, Weiwei Gao, Victor Nizet, PHYSICAL SCIENCES and Liangfang Zhang

APPLIED PHYSICAL SCIENCES ENVIRONMENTAL SCIENCES 11285 Distinct ice patterns on solid surfaces with 11338 Geophysical potential for wind energy over the various wettabilities open oceans Jie Liu, Chongqin Zhu, Kai Liu, Ying Jiang, Yanlin Song, Anna Possner and Ken Caldeira Joseph S. Francisco, Xiao Cheng Zeng, and Jianjun Wang 11446 Diel cycling and long-term persistence of viruses in the ’ BIOPHYSICS AND COMPUTATIONAL BIOLOGY ocean s euphotic zone Frank O. Aylward, Dominique Boeuf, Daniel R. Mende, Elisha M. 11291 Nonequilibrium fluctuations of lipid membranes by the Wood-Charlson, Alice Vislova, John M. Eppley, Anna E. rotating motor F1F0-ATP synthase Romano, and Edward F. DeLong Vı´ctor G. Almendro-Vedia, Paolo Natale, Michael Mell, Stephanie Bonneau, Francisco Monroy, Frederic Joubert, PHYSICS and Iva´n Lo´pez-Montero E8967 Topological phenomena in classical optical networks 11410 Pressure effects on collective density fluctuations in T. Shi, H. J. Kimble, and J. I. Cirac water and protein solutions 11344 Resistivity bound for hydrodynamic bad metals Daniela Russo, Alessio Laloni, Alessandra Filabozzi, and Matthias Heyden Andrew Lucas and Sean A. Hartnoll 11350 The topography of the environment alters the optimal CHEMISTRY search strategy for active particles E8957 Unique amalgamation of primary and secondary Giorgio Volpe and Giovanni Volpe structural elements transform peptaibols into 11356 Configurational entropy measurements in extremely potent bioactive -penetrating peptides supercooled liquids that break the glass ceiling Lin Du, April L. Risinger, Carter A. Mitchell, Jianlan You, Blake W. Ludovic Berthier, Patrick Charbonneau, Daniele Coslovich, Stamps, Ning Pan, Jarrod B. King, Jean C. Bopassa, Susan I. V. Andrea Ninarello, Misaki Ozawa, and Sho Yaida Judge, Zhibo Yang, Bradley S. Stevenson, 11362 Universal photonic quantum computation via and Robert H. Cichewicz time-delayed feedback 11297 Semiconductor quantum dot-sensitized rainbow Hannes Pichler, Soonwon Choi, Peter Zoller, photocathode for effective photoelectrochemical and Mikhail D. Lukin hydrogen generation Hongjin Lv, Congcong Wang, Guocan Li, Rebeckah Burke, STATISTICS Todd D. Krauss, Yongli Gao, and Richard Eisenberg 11368 Big data modeling to predict platelet usage and 11303 Multielectron, multisubstrate molecular catalysis of minimize wastage in a tertiary care system electrochemical reactions: Formal kinetic analysis Leying Guan, Xiaoying Tian, Saurabh Gombar, Allison J. Zemek, in the total catalysis regime Gomathi Krishnan, Robert Scott, Balasubramanian Narasimhan, Cyrille Costentin, Daniel G. Nocera, and Casey N. Brodsky Robert J. Tibshirani, and Tho D. Pham 11309 Production of diverse PET probes with limited SUSTAINABILITY SCIENCE 18 resources: 24 F-labeled compounds prepared 11338 Geophysical potential for wind energy over the with a single radiosynthesizer open oceans Jeffrey Collins, Christopher M. Waldmann, Christopher Drake, Anna Possner and Ken Caldeira Roger Slavik, Noel S. Ha, Maxim Sergeev, Mark Lazari, Bin Shen, Frederick T. Chin, Melissa Moore, Saman Sadeghi, Michael E. Phelps, Jennifer M. Murphy, and R. Michael van Dam SOCIAL SCIENCES 11315 Prebiotic stereoselective synthesis of purine and noncanonical pyrimidine nucleotide from nucleobases PSYCHOLOGICAL AND COGNITIVE SCIENCES and phosphorylated carbohydrates 11374 Rethinking people’s conceptions of mental Hyo-Joong Kim and Steven A. Benner Kara Weisman, Carol S. Dweck, and Ellen M. Markman

iv u www.pnas.org Contents Downloaded by guest on September 30, 2021 SOCIAL SCIENCES 11428 Self-association of a highly charged arginine-rich 11380 How truth wins in opinion dynamics along cell-penetrating peptide issue sequences Giulio Tesei, Mario Vazdar, Malene Ringkjøbing Jensen, Noah E. Friedkin and Francesco Bullo Carolina Cragnell, Phil E. Mason, Jan Heyda, Marie Skepo¨, Pavel Jungwirth, and Mikael Lund 11434 Evidence of evolutionary selection for BIOLOGICAL SCIENCES cotranslational folding William M. Jacobs and Eugene I. Shakhnovich AGRICULTURAL SCIENCES 11386 Engineering sulfur storage in maize seed CELL BIOLOGY without apparent yield loss E8996 Staufen1 inhibits MyoD translation to actively maintain Jose Planta, Xiaoli Xiang, Thomas Leustek, muscle stem cell quiescence and Joachim Messing Antoine de Morre´e, Cindy T. J. van Velthoven, Qiang Gan, Jayesh S. Salvi, Julian D. D. Klein, Igor Akimenko, Marco Quarta, Stefano Biressi, and Thomas A. Rando BIOCHEMISTRY E9006 Content of mitochondrial calcium uniporter (MCU) in E8977 Mechanistic principles underlying regulation of the cardiomyocytes is regulated by microRNA-1 in actin cytoskeleton by phosphoinositides physiologic and pathologic hypertrophy Yosuke Senju, Maria Kalimeri, Essi V. Koskela, Pentti Somerharju, Tania Zaglia, Paola Ceriotti, Antonio Campo, Giulia Borile, Hongxia Zhao, Ilpo Vattulainen, and Pekka Lappalainen Andrea Armani, Pierluigi Carullo, Valentina Prando, Raffaele E8987 Broad role for YBX1 in defining the small noncoding Coppini, Vladimiro Vida, Tomas O. Stølen, Wisløff Ulrik, RNA composition of exosomes Elisabetta Cerbai, Giovanni Stellin, Giuseppe Faggian, Diego Matthew J. Shurtleff, Jun Yao, Yidan Qin, Ryan M. Nottingham, De Stefani, Marco Sandri, Rosario Rizzuto, Fabio Di Lisa, Morayma M. Temoche-Diaz, Randy Schekman, Tullio Pozzan, Daniele Catalucci, and Marco Mongillo and Alan M. Lambowitz 11440 Intragenic DNA methylation and BORIS-mediated 11392 Small-molecule inhibitors directly target CARD9 and -specific splicing contribute to the mimic its protective variant in inflammatory Warburg effect bowel disease Smriti Singh, Sathiya Pandi Narayanan, Kajal Biswas, Amit Elizaveta S. Leshchiner, Jason S. Rush, Michael A. Durney, Gupta, Neha Ahuja, Sandhya Yadav, Rajendra Kumar Panday, Zhifang Cao, Vlado Dancı´k, Benjamin Chittick, Huixian Wu, Atul Samaiya, Shyam K. Sharan, and Sanjeev Shukla Adam Petrone, Joshua A. Bittker, Andrew Phillips, Jose R. DEVELOPMENTAL BIOLOGY Perez, Alykhan F. Shamji, Virendar K. Kaushik, Mark J. Daly, Daniel B. Graham, Stuart L. Schreiber, and Ramnik J. Xavier E9016 Modulation of apoptotic response by LAR family – 11398 PrimPol is required for replication reinitiation after phosphatases cIAP1 signaling during urinary mtDNA damage tract morphogenesis Katherine Stewart, You Chi Tang, Maxwell E. R. Shafer, Rube´n Torregrosa-Mun˜umer, Josefin M. E. Forslund, Steffi Adda-Lee Graham-Paquin, and Maxime Bouchard Goffart, Annika Pfeiffer, Gorazd Stojkovic, Gustavo Carvalho, Natalie Al-Furoukh, Luis Blanco, Sjoerd Wanrooij, ECOLOGY and Jaakko L. O. Pohjoisma¨ki 11446 Diel cycling and long-term persistence of viruses in the 11404 SHMT inhibitors reveal defective glycine ocean’s euphotic zone import as a targetable metabolic vulnerability Frank O. Aylward, Dominique Boeuf, Daniel R. Mende, Elisha M. of diffuse large B-cell lymphoma Wood-Charlson, Alice Vislova, John M. Eppley, Anna E. Gregory S. Ducker, Jonathan M. Ghergurovich, Nello Mainolfi, Romano, and Edward F. DeLong Vipin Suri, Stephanie K. Jeong, Sophia Hsin-Jung Li, Adam Friedman, Mark G. Manfredi, Zemer Gitai, Hahn Kim, 11452 Phylogenetic diversity anomaly in angiosperms and Joshua D. Rabinowitz between eastern Asia and eastern North America Hong Qian, Yi Jin, and Robert E. Ricklefs 11458 Soilborne fungi have host affinity and host-specific BIOPHYSICS AND COMPUTATIONAL BIOLOGY effects on seed germination and survival in a 11291 Nonequilibrium fluctuations of lipid membranes by the lowland tropical forest rotating motor protein F1F0-ATP synthase Carolina Sarmiento, Paul-Camilo Zalamea, James W. Dalling, Vı´ctor G. Almendro-Vedia, Paolo Natale, Michael Mell, Adam S. Davis, Simon M. Stump, Jana M. U’Ren, Stephanie Bonneau, Francisco Monroy, Frederic Joubert, and A. Elizabeth Arnold and Iva´n Lo´pez-Montero 11464 Competitive network determines the direction of the 11410 Pressure effects on collective density fluctuations in diversity–function relationship water and protein solutions Daniel S. Maynard, Thomas W. Crowther, and Mark A. Bradford Daniela Russo, Alessio Laloni, Alessandra Filabozzi, and Matthias Heyden ENVIRONMENTAL SCIENCES 11416 Multiple interactions between an Arf/GEF complex 11321 Bird specimens track 135 years of atmospheric black and charged lipids determine activation kinetics on carbon and environmental policy the membrane Shane G. DuBay and Carl C. Fuldner Deepti Karandur, Agata Nawrotek, John Kuriyan, and Jacqueline Cherfils EVOLUTION See Commentary on page 11266 E9026 Mutator genomes decay, despite sustained fitness 11422 Molecular basis for unique specificity of human TRAF4 gains, in a long-term experiment with bacteria for platelets GPIbβ and GPVI Alejandro Couce, Larissa Viraphong Caudwell, Christoph Chang Min Kim, Young-Jin Son, Sunghwan Kim, Seo Yun Kim, Feinauer, Thomas Hindre´, Jean-Paul Feugeas, Martin Weigt, and Hyun Ho Park Richard E. Lenski, Dominique Schneider, and Olivier Tenaillon

Contents PNAS u October 24, 2017 u vol. 114 u no. 43 u v Downloaded by guest on September 30, 2021 E9036 Kinship and familiarity mitigate costs of social conflict 11275 SMELL-S and SMELL-R: Olfactory tests not influenced between Seychelles warbler neighbors by odor-specific insensitivity or prior Kat Bebbington, Sjouke A. Kingma, Eleanor A. Fairfield, olfactory experience Hannah L. Dugdale, Jan Komdeur, Lewis G. Spurgin, Julien W. Hsieh, Andreas Keller, Michele Wong, Rong-San and David S. Richardson Jiang, and Leslie B. Vosshall 11470 Insight into the growth pattern and bone fusion 11368 Big data modeling to predict platelet usage and of basal birds from an Early Cretaceous minimize wastage in a tertiary care system enantiornithine bird Leying Guan, Xiaoying Tian, Saurabh Gombar, Allison J. Zemek, Min Wang, Zhiheng Li, and Zhonghe Zhou Gomathi Krishnan, Robert Scott, Balasubramanian Narasimhan, Robert J. Tibshirani, and Tho D. Pham GENETICS 11488 Macrophage-like nanoparticles concurrently absorbing E9046 UTX-guided neural crest function underlies endotoxins and proinflammatory cytokines for craniofacial features of Kabuki syndrome sepsis management Karl B. Shpargel, Joshua Starmer, Chaochen Wang, Kai Ge, Soracha Thamphiwatana, Pavimol Angsantikul, Tamara and Terry Magnuson Escajadillo, Qiangzhe Zhang, Joshua Olson, Brian T. Luk, Sophia Zhang, Ronnie H. Fang, Weiwei Gao, Victor Nizet, 11476 FGF4 retrogene on CFA12 is responsible for and Liangfang Zhang chondrodystrophy and intervertebral disc Twist1 disease in dogs 11494 Breast tumor cell-specific knockout of inhibits Emily A. Brown, Peter J. Dickinson, Tamer Mansour, Beverly K. cancer cell plasticity, dissemination, and lung Sturges, Miriam Aguilar, Amy E. Young, Courtney Korff, Jenna metastasis in mice Lind, Cassandra L. Ettinger, Samuel Varon, Rachel Pollard, Yixiang Xu, Dong-Kee Lee, Zhen Feng, Yan Xu, Wen Bu, Yi Li, C. Titus Brown, Terje Raudsepp, and Danika L. Bannasch Lan Liao, and Jianming Xu 11500 Ninjurin 1 has two opposing functions in IMMUNOLOGY AND INFLAMMATION tumorigenesis in a p53-dependent manner E9056 Human papillomavirus oncoproteins induce a Hee Jung Yang, Jin Zhang, Wensheng Yan, Seong-Jun Cho, reorganization of epithelial-associated γδ Christopher Lucchesi, Mingyi Chen, Eric C. Huang, Ariane T cells promoting tumor formation Scoumanne, Weici Zhang, and Xinbin Chen Dorien Van hede, Barbara Polese, Chantal Humblet, Anneke Wilharm, Virginie Renoux, Estelle Dortu, Laurence de Leval, Philippe Delvenne, Christophe J. Desmet, Fabrice Bureau, MICROBIOLOGY David Vermijlen, and Nathalie Jacobs E9105 Spatial organization of a model 15-member human gut 11482 Selective neutralization of IL-12 p40 monomer induces microbiota established in gnotobiotic mice death in prostate cancer cells via IL-12–IFN-γ Jessica L. Mark Welch, Yuko Hasegawa, Nathan P. McNulty, Madhuchhanda Kundu, Avik Roy, and Kalipada Pahan Jeffrey I. Gordon, and Gary G. Borisy 11506 Inhibition of DAI-dependent necroptosis by the MEDICAL SCIENCES Z-DNA binding domain of the vaccinia virus E9066 Packaging and transfer of mitochondrial DNA via innate immune evasion protein, E3 exosomes regulate escape from dormancy in Heather Koehler, Samantha Cotsmire, Jeffrey Langland, hormonal therapy-resistant breast cancer Karen V. Kibler, Daniel Kalman, Jason W. Upton, Edward S. Mocarski, and Bertram L. Jacobs Pasquale Sansone, Claudia Savini, Ivana Kurelac, Qing Chang, Laura Benedetta Amato, Antonio Strillacci, Anna Stepanova, 11512 Maladaptive DNA repair is the ultimate contributor Luisa Iommarini, Chiara Mastroleo, Laura Daly, Alexander to the death of trimethoprim-treated cells under Galkin, Basant Kumar Thakur, Nadine Soplop, Kunihiro Uryu, aerobic and anaerobic conditions Ayuko Hoshinob, Larry Norton, Massimiliano Bonafe´, Xavier Giroux, Wei-Lin Su, Marie-Florence Bredeche, Monica Cricca, Giuseppe Gasparre, David Lyden, and Ivan Matic and Jacqueline Bromberg E9076 Human papillomavirus oncogenes reprogram the cervical cancer microenvironment independently NEUROSCIENCE of and synergistically with estrogen E9115 Visual perception as retrospective Bayesian decoding Megan E. Spurgeon, Johan A. den Boon, Mark Horswill, Sonalee from high- to low-level features Barthakur, Omid Forouzan, Janet S. Rader, David J. Beebe, Stephanie Ding, Christopher J. Cueva, Misha Tsodyks, Avtar Roopra, Paul Ahlquist, and Paul F. Lambert and Ning Qian E9086 PAF promotes stemness and radioresistance of glioma E9125 Opioid and orexin hedonic hotspots in stem cells orbitofrontal cortex and insula Derrick Sek Tong Ong, Baoli Hu, Yan Wing Ho, Charles-Etienne Daniel C. Castro and Kent C. Berridge Gabriel Sauve´, Christopher A. Bristow, Qianghu Wang, Asha S. Multani, Peiwen Chen, Luigi Nezi, Shan Jiang, Claire Elizabeth E9135 M344 promotes nonamyloidogenic amyloid precursor Gorman, Marta Moreno Monasterio, Dimpy Koul, Matteo protein processing while normalizing Alzheimer’s Marchesini, Simona Colla, Eun-Jung Jin, Erik P. Sulman, disease genes and improving memory Denise J. Spring, Wai-Kwan Alfred Yung, Roel G. W. Verhaak, Claude-Henry Volmar, Hasib Salah-Uddin, Karolina J. Janczura, Lynda Chin, Y. Alan Wang, and Ronald A. DePinho Paul Halley, Guerline Lambert, Andrew Wodrich, Sivan Manoah, E9096 Cardiovascular homeostasis dependence on MICU2, Nidhi H. Patel, Gregory C. Sartor, Neil Mehta, Nancy T. H. Miles, a regulatory subunit of the mitochondrial Sachi Desse, David Dorcius, Michael D. Cameron, Shaun P. Brothers, and Claes Wahlestedt calcium uniporter Alexander G. Bick, Hiroko Wakimoto, Kimberli J. Kamer, E9145 Perceiving social interactions in the posterior Yasemin Sancak, Olga Goldberger, Anna Axelsson, Daniel M. superior temporal sulcus DeLaughter, Joshua M. Gorham, Vamsi K. Mootha, J. G. Leyla Isik, Kami Koldewyn, David Beeler, Seidman, and Christine E. Seidman and Nancy Kanwisher

vi u www.pnas.org Contents Downloaded by guest on September 30, 2021 E9153 Dynein/dynactin is necessary for anterograde PLANT BIOLOGY transport of Mbp mRNA in oligodendrocytes 11536 Natural variation identifies genes affecting and for myelination in vivo drought-induced abscisic acid accumulation Amy L. Herbert, Meng-meng Fu, Catherine M. Drerup, Ryan S. in Arabidopsis thaliana , Breanne L. Harty, Sarah D. Ackerman, Thomas Rajesh Kalladan, Jesse R. Lasky, Trent Z. Chang, O’Reilly-Pol, Stephen L. Johnson, Alex V. Nechiporuk, Ben A. Sandeep Sharma, Thomas E. Juenger, Barres, and Kelly R. Monk and Paul E. Verslues 11518 Local synaptic integration enables ON-OFF asymmetric and layer-specific visual information PSYCHOLOGICAL AND COGNITIVE SCIENCES processing in vGluT3 amacrine cell dendrites 11542 Disruption and rescue of interareal theta phase Minggang Chen, Seunghoon Lee, and Z. Jimmy Zhou coupling and adaptive behavior See Commentary on page 11268 Robert M. G. Reinhart 11524 TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a SYSTEMS BIOLOGY model of tauopathy Cheryl E. G. Leyns, Jason D. Ulrich, Mary B. Finn, Floy R. Stewart, 11548 Thermosensitivity of growth is determined by Lauren J. Koscal, Javier Remolina Serrano, Grace O. Robinson, Elise chaperone-mediated proteome reallocation Anderson, Marco Colonna, and David M. Holtzman Ke Chen, Ye Gao, Nathan Mih, Edward J. O’Brien, Laurence Yang, and Bernhard O. Palsson PHARMACOLOGY

E9163 β2-Adrenoceptor signaling in airway epithelial cells promotes eosinophilic inflammation, mucous CORRECTIONS (ONLINE ONLY) metaplasia, and airway contractility PSYCHOLOGICAL AND COGNITIVE SCIENCES Long P. Nguyen, Nour A. Al-Sawalha, Sergio Parra, Indira Pokkunuri, Ozozoma Omoluabi, Adedoyin A. Okulate, Elizabeth E9181 Higher social class predicts increased Windham Li, Matthew Hazen, Jose M. Gonzalez-Granado, Craig J. unethical behavior Daly,JohnC.McGrath,MichaelJ.Tuvim,BrianJ.Knoll,BurtonF. Paul K. Piff, Daniel M. Stancato, Ste´phane Coˆte´, Rodolfo Dickey, and Richard A. Bond Mendoza-Denton, and Dacher Keltner

PHYSIOLOGY NEUROSCIENCE, APPLIED MATHEMATICS E9172 Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms E9182 Cross-scale effects of neural interactions during Giuseppe Ferrandino, Rachel R. Kaspari, Olga Spadaro, Andrea human neocortical seizure activity Reyna-Neyra, Rachel J. Perry, Rebecca Cardone, Richard G. Kibbey, Tahra L. Eissa, Koen Dijkstra, Christoph Brune, Ronald G. Gerald I. Shulman, Vishwa Deep Dixit, and Nancy Carrasco Emerson, Michel J. A. M. van Putten, Robert R. Goodman, Guy M. McKhann Jr., Catherine A. Schevon, Wim van 11530 Transcription factor ISX mediates the cross talk Drongelen, and Stephan A. van Gils between diet and immunity Made Airanthi K. Widjaja-Adhi, Grzegorz Palczewski, Kali Dale, Elizabeth A. Knauss, Mary E. Kelly, Marcin Golczak, Alan D. Levine, and Johannes von Lintig ix Subscription Form

Contents PNAS u October 24, 2017 u vol. 114 u no. 43 u vii Downloaded by guest on September 30, 2021