DOCSLIB.ORG

Synonyms for Cannabis

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Synonyms for Cannabis Index Index ........................................................................................................................................................................... 1 Foreword .................................................................................................................................................................... 2 Always keep in mind ................................................................................................................................................................................................... 2 About cannabis ........................................................................................................................................................... 3 What is cannabis ........................................................................................................................................................................................................ 3 Synonyms for cannabis ............................................................................................................................................................................................... 4 Male and female cannabis plants ............................................................................................................................................................................... 5 Species and strains ..................................................................................................................................................................................................... 7 Uses of cannabis ....................................................................................................................................................................................................... 10 Cannabinoids ............................................................................................................................................................ 11 What is a cannabinoid .............................................................................................................................................................................................. 11 More on cannabinoids .............................................................................................................................................. 12 Cannabinoid-A .......................................................................................................................................................................................................... 12 Classification of Cannabinoids .................................................................................................................................................................................. 13 Cannabinoid receptors .............................................................................................................................................. 14 What is a cannabinoid receptor ............................................................................................................................................................................... 14 The endocannabinoid system (ECS) .......................................................................................................................................................................... 15 Decarboxylation ........................................................................................................................................................ 16 What is decarboxylation ........................................................................................................................................................................................... 16 Example with THC vs THCA ....................................................................................................................................................................................... 16 Converting THCA to THC ........................................................................................................................................................................................... 16 Decarboxylation on other cannabinoids ................................................................................................................................................................... 17 Dangers of cannabis .................................................................................................................................................. 18 Is cannabis dangerous .............................................................................................................................................................................................. 18 Hidden dangers ........................................................................................................................................................................................................ 19 Overdosing on cannabis ........................................................................................................................................................................................... 20 THC in the human body ............................................................................................................................................. 21 Different forms of THC ............................................................................................................................................................................................. 21 Effects of THC and 11-Hydroxy-THC ......................................................................................................................................................................... 23 Detection of THC in tests .......................................................................................................................................................................................... 25 Consuming THC ........................................................................................................................................................................................................ 27 Cannabis as a medicine ............................................................................................................................................. 29 A little history ........................................................................................................................................................................................................... 29 Medicine or hoax ...................................................................................................................................................................................................... 30 The Leafly Wheel ...................................................................................................................................................................................................... 32 Self-medicating ......................................................................................................................................................................................................... 33 Examples of cannabis at work ................................................................................................................................... 34 Buying cannabis medicine ......................................................................................................................................... 36 Cannabis is illegal in your country ............................................................................................................................................................................ 36 Cannabis is legal in your country .............................................................................................................................................................................. 36 Cannabis is legal, but cannabis medicine is illegal .................................................................................................................................................... 36 Buying off the internet ............................................................................................................................................................................................. 36 THC as a cure for cancer ............................................................................................................................................ 37 Rumours or fact ........................................................................................................................................................................................................ 37 The theory why cannabis can cure cancer ................................................................................................................................................................ 37 Conclusion ................................................................................................................................................................................................................ 38 Making THC oil .......................................................................................................................................................... 39 Where to start .........................................................................................................................................................................................................
Load more

Recommended publications
  • Edinburgh Research Explorer
    Edinburgh Research Explorer International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list Citation for published version: Davenport, AP, Alexander, SPH, Sharman, JL, Pawson, AJ, Benson, HE, Monaghan, AE, Liew, WC, Mpamhanga, CP, Bonner, TI, Neubig, RR, Pin, JP, Spedding, M & Harmar, AJ 2013, 'International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands', Pharmacological reviews, vol. 65, no. 3, pp. 967-86. https://doi.org/10.1124/pr.112.007179 Digital Object Identifier (DOI): 10.1124/pr.112.007179 Link: Link to publication record in Edinburgh Research Explorer Document Version: Publisher's PDF, also known as Version of record Published In: Pharmacological reviews Publisher Rights Statement: U.S. Government work not protected by U.S. copyright General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. Take down policy The University of Edinburgh has made every reasonable effort to ensure that Edinburgh Research Explorer content complies with UK legislation. If you believe that the public display of this file breaches copyright please contact [email protected] providing details, and we will remove access to the work immediately and investigate your claim. Download date: 02. Oct. 2021 1521-0081/65/3/967–986$25.00 http://dx.doi.org/10.1124/pr.112.007179 PHARMACOLOGICAL REVIEWS Pharmacol Rev 65:967–986, July 2013 U.S.
    [Show full text]
  • Identification of Biomarkers for Sarcoidosis and Tuberculosis of The
    DATABASE ANALYSIS e-ISSN 1643-3750 © Med Sci Monit, 2020; 26: e925438 DOI: 10.12659/MSM.925438 Received: 2020.04.26 Accepted: 2020.05.11 Identification of Biomarkers for Sarcoidosis and Available online: 2020.05.28 Published: 2020.07.23 Tuberculosis of the Lung Using Systematic and Integrated Analysis Authors’ Contribution: ABCEF 1 Min Zhao 1 Department of Respiratory and Critical Care Medicine, The Second Hospital of Study Design A BCE 1 Xin Di Jilin University, Changchun, Jilin, P.R. China Data Collection B 2 Department of Oncology and Hematology, The Second Hospital of Jilin University, Statistical Analysis C CDE 2 Xin Jin Changchun, Jilin, P.R. China Data Interpretation D BF 1 Chang Tian Manuscript Preparation E CF 1 Shan Cong Literature Search F Funds Collection G BF 1 Jiangyin Liu ABDEG 1 Ke Wang Corresponding Author: Ke Wang, e-mail: [email protected] Source of support: This study was supported by the Technology Research Funds of Jilin Province (20190303162SF), the Natural Science Foundation of Jilin Province (20180101103JC), and the Medical and Health Project Funds of Jilin Province (20191102012YY) Background: Sarcoidosis (SARC) is a multisystem inflammatory disease of unknown etiology and pulmonary tuberculosis (PTB) is caused by Mycobacterium tuberculosis. Both of these diseases affect lungs and lymph nodes and share similar clinical manifestations. However, the underlying mechanisms for the similarities and differences in ge- netic characteristics of SARC and PTB remain unclear. Material/Methods: Three datasets (GSE16538, GSE20050, and GSE19314) were retrieved from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) in SARC and PTB were identified using GEO2R online analyz- er and Venn diagram software.
    [Show full text]
  • Mass Spectrometry Profiling of Oxylipins, Endocannabinoids, and N
    http://www.diva-portal.org This is the published version of a paper published in Analytical and Bioanalytical Chemistry. Citation for the original published paper (version of record): Gouveia-Figueira, S., Karimpour, M., Bosson, J A., Blomberg, A., Unosson, J. et al. (2017) Mass spectrometry profiling of oxylipins, endocannabinoids, and N-acylethanolamines in human lung lavage fluids reveals responsiveness of prostaglandin E2 and associated lipid metabolites to biodiesel exhaust exposure. Analytical and Bioanalytical Chemistry, 409(11): 2967-2980 https://doi.org/10.1007/s00216-017-0243-8 Access to the published version may require subscription. N.B. When citing this work, cite the original published paper. Permanent link to this version: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-134210 Anal Bioanal Chem (2017) 409:2967–2980 DOI 10.1007/s00216-017-0243-8 RESEARCH PAPER Mass spectrometry profiling of oxylipins, endocannabinoids, and N-acylethanolamines in human lung lavage fluids reveals responsiveness of prostaglandin E2 and associated lipid metabolites to biodiesel exhaust exposure Sandra Gouveia-Figueira1 & Masoumeh Karimpour1 & Jenny A. Bosson2 & Anders Blomberg2 & Jon Unosson 2 & Jamshid Pourazar2 & Thomas Sandström2 & Annelie F. Behndig2 & Malin L. Nording1 Received: 15 December 2016 /Revised: 24 January 2017 /Accepted: 2 February 2017 /Published online: 24 February 2017 # The Author(s) 2017. This article is published with open access at Springerlink.com Abstract The adverse effects of petrodiesel exhaust exposure corrected significance. This is the first study in humans reporting on the cardiovascular and respiratory systems are well recog- responses of bioactive lipids following biodiesel exhaust expo- nized. While biofuels such as rapeseed methyl ester (RME) bio- sure and the most pronounced responses were seen in the more diesel may have ecological advantages, the exhaust generated peripheral and alveolar lung compartments, reflected by BAL may cause adverse health effects.
    [Show full text]
  • Involvement of Microsomal Prostaglandin E Synthase-1-Derived Prostaglandin E2 in Chemical-Induced Carcinogenesis Shuntaro Hara (Showa University, Tokyo, Japan)
    Book of Abstracts Thursday, October 23th SESSION 1: PGE2 in PATHOPHYSIOLOGY SESSION 2: PROSTAGLANDINS and CARDIOVASCULAR SYSTEM SESSION 3: NOVEL LIPID MEDIATORS and ADVANCES in LIPID MEDIATOR ANALYTICS Friday, October 24th YOUNG INVESTIGATOR SESSION SESSION 4: LIPOXYGENASES SESSION 5: ADIPOSE TISSUE and BIOACTIVE LIPIDS GOLD SPONSORS http://workshop-lipid.eu MAJOR SPONSORS 1 SPONSORS 2 SCIENTIFIC AND EXECUTIVE COMMITTEE Gerard BANNENBERG Global Organization for EPA and DHA (GOED), Madrid, Spain E-mail: [email protected] Joan CLÀRIA Department of Biochemistry and Molecular Genetics Hospital Clínic/IDIBAPS Villarroel 170 08036 Barcelona, Spain E-mail: [email protected] Per-Johan JAKOBSSON Karolinska Institutet Dept of Medicine 171 76 Stockholm, Sweden E-mail: [email protected] Jane A. MITCHELL NHLI, Imperial College, London SW3 6LY, United Kingdom E-mail: [email protected] Xavier NOREL INSERM U1148, Bichat Hospital 46, rue Henri Huchard 75018 Paris, France E-mail: [email protected] Dieter STEINHILBER Institut fuer Pharmazeutische Chemie Universitaet Frankfurt, Frankfurt, Germany E-mail: [email protected] Gökçe TOPAL Istanbul University Faculty of Pharmacy Department of Pharmacology Beyazit, 34116, Istanbul, Turkey E-mail: [email protected] Sönmez UYDEŞ DOGAN Istanbul University, Faculty of Pharmacy, Department of Pharmacology Beyazit, 34116, Istanbul, Turkey E-mail: [email protected] Tim WARNER The William Harvey Research Institute Barts& the London School of Medicine & Dentistry, United
    [Show full text]
  • N-Acyl Amino Acids (Elmiric Acids): Endogenous Signaling Molecules with Therapeutic Potential
    Molecular Pharmacology Fast Forward. Published on November 14, 2017 as DOI: 10.1124/mol.117.110841 This article has not been copyedited and formatted. The final version may differ from this version. MOL #110841 1 MINIREVIEW N-Acyl amino acids (Elmiric Acids): endogenous signaling molecules with therapeutic potential Sumner H. Burstein Department of Biochemistry & Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 Downloaded from molpharm.aspetjournals.org at ASPET Journals on September 30, 2021 Molecular Pharmacology Fast Forward. Published on November 14, 2017 as DOI: 10.1124/mol.117.110841 This article has not been copyedited and formatted. The final version may differ from this version. MOL #110841 2 Running title. N-Acyl amino acids; endogenous signaling molecules Corresponding author: Sumner H. Burstein, Department of Biochemistry & Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 [email protected] Phone: 508-856-2850 FAX: 508-856-2251 Number of of text pages, 26 Number of tables, 3 Downloaded from Number of figures, 4 Number of references, 60 Number of words in the: molpharm.aspetjournals.org Abstract, 220 Introduction, 742 Discussion, 6338 Abbreviations: COX, cyclooxygenase; FAAH, fatty acid amide hydrolase; GABA, γ- at ASPET Journals on September 30, 2021 aminobutyric acid; GPCR, G-protein coupled receptor; LXA4, lipoxin A4 ; LOX, 12,14 lipoxygenases; PGJ,15-deoxy-Δ -prostaglandin-J2 Molecular Pharmacology Fast Forward. Published on November 14, 2017 as DOI: 10.1124/mol.117.110841 This article has not been copyedited and formatted. The final version may differ from this version. MOL #110841 3 Abstract The subject of N-acyl amino acid conjugates has been rapidly growing in recent years, especially with regard to their analgesic and anti-inflammatory actions.
    [Show full text]
  • Modulatory Ośrodkowego Układu Nerwowego
    Tom 69 2020 Numer 3 (328) Strony 431–440 Monika Leśkiewicz Zakład Neuroendokrynologii Doświadczalnej Instytut Farmakologii im. Jerzego Maja PAN Smętna 12, 31-343 Kraków E-mail: [email protected] NEUROSTEROIDY – MODULATORY OŚRODKOWEGO UKŁADU NERWOWEGO NEUROAKTYWNE STEROIDY – sję genów jest procesem skomplikowanym, GENOMOWY I NIEGENOMOWY wieloetapowym i długotrwałym, co oznacza, MECHANIZM DZIAŁANIA że pierwsze zmiany ekspresji genów, będą- ce następstwem działania hormonów stero- Przypadkowe odkrycie kilkadziesiąt lat idowych, zaobserwować można co najmniej temu właściwości nasennych i przeciwdr- po kilku godzinach od ekspozycji. Cząstecz- gawkowych progesteronu zapoczątkowało ka steroidowa po wniknięciu do cytoplazmy badania nad wpływem hormonów steroido- przyłącza się do kompleksu receptorowego. wych na aktywność neuronów (SELYE 1942, Receptor w formie nieaktywnej jest połączo- ATKINSON i współaut. 1965). Steroidy: hor- ny z białkami opiekuńczymi Hsp70, Hsp90 mony płciowe, glikokortykosteroidy, minera- i p23 oraz immunofilinami z rodziny białek lokortykosteroidy, łatwo przenikają do ośrod- FK506. Po związaniu steroidowego liganda kowego układu nerwowego (OUN) modulu- następuje oddysocjowanie białek opiekuń- jąc jego pobudliwość. Regulują one funkcje czych, fosforylacja (aktywacja) receptora, OUN głównie na drodze złożonego procesu który, jako homodimer, przemieszcza się do związanego z regulacją transkrypcji genów, jądra. Tam ulega kolejnej dimeryzacji i ra- przy udziale receptorów cytoplazmatycznych/ zem z koregulatorami przyłącza się do od- jądrowych (ang. genomic action). Niektóre powiedniego fragmentu DNA, tzw. elementu hormony steroidowe, np. 17β-estradiol, wią- HRE (ang. hormone-response element). Ko- żą się z receptorami błonowymi związanymi regulatory albo promują transkrypcję (koak- z białkami G (ang. G Protein-coupled estro- tywatory, np. SRC-1; ang. steroid receptor gen receptor, GPER), aktywując wewnątrz- co-activator) albo ją hamują (korepresory, komórkowe szlaki sygnałowe (ang.
    [Show full text]
  • Endocannabinoids and Reproduction
    International Journal of Endocrinology Endocannabinoids and Reproduction Guest Editors: Rosaria Meccariello, Natalia Battista, Heather B. Bradshaw, and Haibin Wang Endocannabinoids and Reproduction International Journal of Endocrinology Endocannabinoids and Reproduction Guest Editors: Rosaria Meccariello, Natalia Battista, Heather B. Bradshaw, and Haibin Wang Copyright © 2014 Hindawi Publishing Corporation. All rights reserved. This is a special issue published in “International Journal of Endocrinology.” All articles are open access articles distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial Board Anil K. Agarwal, USA K. Hussain, UK Muhammad Shahab, Pakistan Stephen L. Atkin, UK Daniela Jezova, Slovakia Kazuhiro Shiizaki, Japan John Ayuk, UK J. Karalliedde, UK Kevin Sinchak, USA Amelie Bonnefond, France Małgorzata Kotula-Balak, Poland Stacia A. Sower, USA Shern L. Chew, UK Fernand Labrie, Canada Ajai Kumar Srivastav, India F. X. Donadeu, UK Mario Maggi, Italy Stanko S. Stojilkovic, USA Maria L. Dufau, USA Robert D. Murray, UK Robert S. Tan, USA Kristin Eckardt, Germany Maria New, USA Stuart Tobet, USA Dariush Elahi, USA Faustino R. Perez-L´ opez,´ Spain Jack R. Wall, Australia Oreste Gualillo, Spain Ursula Plockinger,¨ Germany Paul M. Yen, USA A. Hoflich,¨ Germany Alexander Schreiber, USA Naveed Younis, United Kingdom Contents Endocannabinoids and Reproduction, Rosaria Meccariello, Natalia Battista, Heather B. Bradshaw, and Haibin Wang Volume 2014, Article ID 378069, 2 pages Updates in Reproduction Coming from the Endocannabinoid System, Rosaria Meccariello, Natalia Battista, Heather B. Bradshaw, and Haibin Wang Volume 2014, Article ID 412354, 16 pages The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers, Thangesweran Ayakannu, Anthony H.
    [Show full text]
  • N-Acyl Amino Acids (Elmiric Acids): Endogenous Signaling Molecules with Therapeutic Potential
    Molecular Pharmacology Fast Forward. Published on November 14, 2017 as DOI: 10.1124/mol.117.110841 This article has not been copyedited and formatted. The final version may differ from this version. MOL #110841 1 MINIREVIEW N-Acyl amino acids (Elmiric Acids): endogenous signaling molecules with therapeutic potential Sumner H. Burstein Department of Biochemistry & Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 Downloaded from molpharm.aspetjournals.org at ASPET Journals on September 27, 2021 Molecular Pharmacology Fast Forward. Published on November 14, 2017 as DOI: 10.1124/mol.117.110841 This article has not been copyedited and formatted. The final version may differ from this version. MOL #110841 2 Running title. N-Acyl amino acids; endogenous signaling molecules Corresponding author: Sumner H. Burstein, Department of Biochemistry & Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 [email protected] Phone: 508-856-2850 FAX: 508-856-2251 Number of of text pages, 26 Number of tables, 3 Downloaded from Number of figures, 4 Number of references, 60 Number of words in the: molpharm.aspetjournals.org Abstract, 220 Introduction, 742 Discussion, 6338 Abbreviations: COX, cyclooxygenase; FAAH, fatty acid amide hydrolase; GABA, γ- at ASPET Journals on September 27, 2021 aminobutyric acid; GPCR, G-protein coupled receptor; LXA4, lipoxin A4 ; LOX, 12,14 lipoxygenases; PGJ,15-deoxy-Δ -prostaglandin-J2 Molecular Pharmacology Fast Forward. Published on November 14, 2017 as DOI: 10.1124/mol.117.110841 This article has not been copyedited and formatted. The final version may differ from this version. MOL #110841 3 Abstract The subject of N-acyl amino acid conjugates has been rapidly growing in recent years, especially with regard to their analgesic and anti-inflammatory actions.
    [Show full text]
  • Polyclonal Antibody to GPR18 / Nagly Receptor (1St Extracell
    OriGene Technologies, Inc. OriGene Technologies GmbH 9620 Medical Center Drive, Ste 200 Schillerstr. 5 Rockville, MD 20850 32052 Herford UNITED STATES GERMANY Phone: +1-888-267-4436 Phone: +49-5221-34606-0 Fax: +1-301-340-8606 Fax: +49-5221-34606-11 [email protected] [email protected] SP4733P Polyclonal Antibody to GPR18 / NAGly receptor (1st Extracell. Dom.) - Aff - Purified Alternate names: G protein-coupled receptor 18, GPCRW, N-arachidonyl glycine receptor Quantity: 50 µg Concentration: 0.5 mg/ml Background: GPR18 is an Orphan-A GPCR with no known ligand. GPR18 has been reported to be expressed at high levels in testis and spleen and at lower levels in other tissues associated with endocrine and immunologic/hematologic functions. ESTs have been isolated from human blood, bone marrow, brain, colon, liver/spleen, lymph, lymph node, testis, and tonsil libraries. Uniprot ID: Q14330 NCBI: NP_001091670.1 GeneID: 2841 Host: Rabbit Immunogen: Synthetic 18 amino acid peptide from 1st extracellular domain of human GPR18 / NAGly receptor Remarks: Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset, Mouse, Hamster, Panda, Dog, Horse (94%); Rat, Bat, Bovine (89%); Elephant, Rabbit, Pig (83%). BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR174 (44%). Format: State: Liquid Ig fraction Purification: Immunoaffinity chromatography Buffer System: PBS containing 0.09% Sodium azide Applications: Immunohistochemistry on Paraffin Sections: 6 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Specificity: This antibody recognizes 1st extracellular domain of GPR18 / NAGly receptor.
    [Show full text]
  • Postępy Andrologii Online Advances in Andrology Online
    e-ISSN 2353-8791 ICV = 69,63 Czasopismo Polskiego Towarzystwa Andrologicznego Journal of Polish Society of Andrology Tom 6 • Numer 2 • Grudzień 2019 Volumin 6 • Number 2 • December 2019 Postępy Andrologii Online Advances in Andrology Online Immunohistochemiczna lokalizacja komórek tucznych CD117-pozytywnych (ciemnobrązowe zabarwienie) w zrębie prostaty szczura. Mikrofotografie autorstwa dr n. med. Marty Grabowskiej, Zakład Histologii i Biologii Rozwoju, Pomorski Uniwersytet Medyczny w Szczecinie. Immunohistochemical localization of CD117-positive mast cells (dark brown staining) in the stroma of the rat prostate. Micrographs by PhD Marta Grabowska, Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin. POSTĘPY ANDROLOGII ONLINE, 2019, 6 (2), 2 e-ISSN 2353-8791 ICV = 69,63 Czasopismo Polskiego Towarzystwa Andrologicznego Czasopismo Polskiego Towarzystwa Andrologicznego Journal of Polish Society of Andrology Tom 6 • Numer 2 • Grudzień 2019 Volumin 6 • Number 2 • December 2019 Postępy Andrologii Postępy Andrologii Online Online Advances in Andrology Online Advances in Andrology Online Immunohistochemiczna lokalizacja komórek tucznych CD117-pozytywnych (ciemnobrązowe zabarwienie) w zrębie prostaty szczura. Mikrofotogra e autorstwa dr n. med. Marty Grabowskiej, Zakład Histologii i Biologii Rozwoju, Pomorski Uniwersytet Medyczny w Szczecinie. Immunohistochemical localization of CD117-positive mast cells (dark brown staining) in the stroma of the rat prostate. Micrographs http://www.postepyandrologii.pl by PhD Marta Grabowska, Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin. KOMITET REDAKCYJNY Redaktor naczelny: dr hab. n. med., prof. nadzw. PUM Małgorzata Piasecka, Szczecin Zastępca redaktora naczelnego: prof. dr hab. n. med. Jolanta Słowikowska-Hilczer, Łódź Redaktor pomocniczy: dr n. med. Kamil Gill, Szczecin Sekretarz redakcji: dr hab. n. med. Agnieszka Kolasa-Wołosiuk, Szczecin Skarbnik redakcji: dr hab.
    [Show full text]
  • The Endocannabinoid System As a Therapeutic Target in Glaucoma
    Hindawi Publishing Corporation Neural Plasticity Volume 2016, Article ID 9364091, 10 pages http://dx.doi.org/10.1155/2016/9364091 Review Article The Endocannabinoid System as a Therapeutic Target in Glaucoma Elizabeth A. Cairns,1 William H. Baldridge,2,3 and Melanie E. M. Kelly1,3 1 Department of Pharmacology, Dalhousie University, Halifax, NS, Canada B3H 4R2 2Department of Medical Neuroscience, Dalhousie University, Halifax, NS, Canada B3H 4R2 3Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, NS, Canada B3H 4R2 Correspondence should be addressed to Melanie E. M. Kelly; [email protected] Received 10 July 2015; Accepted 10 November 2015 Academic Editor: Maurice Ptito Copyright © 2016 Elizabeth A. Cairns et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Glaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the disorder. The endocannabinoid system (ECS) has attracted considerable attention as a potential target for the treatment of glaucoma, largely due to the observed IOP lowering effects seen after administration of exogenous cannabinoids. However, recent evidence has suggested that modulation of the ECS may also be neuroprotective. This paper will review the use of cannabinoids in glaucoma, presenting pertinent information regarding the pathophysiology of glaucoma and how alterations in cannabinoid signalling may contribute to glaucoma pathology. Additionally, the mechanisms and potential for the use of cannabinoids and other novel agents that target the endocannabinoid system in the treatment of glaucoma will be discussed.
    [Show full text]
  • UC San Francisco Electronic Theses and Dissertations
    UCSF UC San Francisco Electronic Theses and Dissertations Title Immune regulation by the endocannabinoid N-arachidonoyl dopamine (NADA) Permalink https://escholarship.org/uc/item/7wj3d52v Author Lawton, Samira Khakpour Publication Date 2017 Peer reviewed|Thesis/dissertation eScholarship.org Powered by the California Digital Library University of California Immune regulation by the endocannabinoid rV-ar: dopamine by DISSERTATION Submitted in partial satisfaction of the requirements for the degree of Copyright 2017 by Samira Khakpour Lawton ii To Kipp Lawton, my best friend iii ACKNOWLEDGEMENTS First, I would like to thank my graduate advisor, Judith Hellman, for her unconditional support and scientific guidance. Through creativity and determination, we set forth into new frontiers, and I am a better scientist for it. She taught me to follow my heart and never fear the unknown. Judith allowed me to be independent while never feeling alone. I am deeply grateful to have had the chance to experience graduate school with her by my side and will miss her immensely. I also truly appreciate having been able to do science with the rest of the Hellman lab. Fengyun Xu and Erika Wong spent uncountable hours repeating complex experiments, and Alphonso Tran sacrificed endless nights and weekends to help move this project along. I sincerely could not have done this without all of their help and support. Finally, I greatly appreciate my undergraduate research advisor, Will DePaolo, who gave me the foundation in research that has been crucial to my success at UCSF. I would also like to thank my thesis committee, Matt Springer, Shaun Coughlin, and Mehrdad Matloubian, for their consistent guidance and inspiration.
    [Show full text]