10.1101/2020.07.29.227421; This Version Posted July 30, 2020
bioRxiv preprint doi: https://doi.org/10.1101/2020.07.29.227421; this version posted July 30, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 1 Title: Genomic insights into the host specific adaptation of the Pneumocystis genus and 2 emergence of the human pathogen Pneumocystis jirovecii 3 4 Short title: Pneumocystis fungi adaptation to mammals 5 6 Authors: Ousmane H. Cissé1*†, Liang Ma1*†, John P. Dekker2,3, Pavel P. Khil2,3, Jung-Ho 7 Youn3, Jason M. Brenchley4, Robert Blair5, Bapi Pahar5, Magali Chabé6, Koen K.A. Van 8 Rompay7, Rebekah Keesler7, Antti Sukura8, Vanessa Hirsch9, Geetha Kutty1, Yueqin Liu 9 1, Peng Li10, Jie Chen10, Jun Song11, Christiane Weissenbacher-Lang12, Jie Xu11, Nathan 10 S. Upham13, Jason E. Stajich14, Christina A. Cuomo15, Melanie T. Cushion16 and Joseph 11 A. Kovacs1* 12 13 Affiliations: 1 Critical Care Medicine Department, NIH Clinical Center, National 14 Institutes of Health, Bethesda, Maryland, USA. 2 Bacterial Pathogenesis and 15 Antimicrobial Resistance Unit, National Institute of Allergy and Infectious Diseases, 16 National Institutes of Health, Bethesda, Maryland, USA. 3 Department of Laboratory 17 Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, Maryland, USA. 18 4 Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, 19 National Institutes of Health, Bethesda, Maryland, USA. 5 Tulane National Primate 20 Research Center, Tulane University, New Orleans, Louisiana, USA. 6 Univ. Lille, CNRS, 21 Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Centre d'Infection 22 et d'Immunité de Lille, Lille, France.
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