IRENAT 300 Mg/Ml, Solution Buvable En Gouttes
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Physician Perchlorate Fact Sheet
Physician Fact Sheet PERCHLORATE Environmental Epidemiology and Toxicology Division HIGHLIGHTS: Perchlorate competitively inhibits the uptake of iodide by the thyroid gland potentially affecting thyroid function. Pregnant women and their developing fetus may be more susceptible to the effects of perchlorate because of the stress that pregnancy places on the thyroid gland. Disruption of thyroid function could put pregnant women at greater risk for pregnancy-related complications such as preeclampsia, placental abruption, and low birth weight infants. An adequate iodine intake may negate the potential effects. Exposure levels that affect thyroid function have not been well demonstrated in humans. Currently, a National Primary Drinking Water Regulation for perchlorate does not exist. For more information, call the Texas Department of Health Environmental Epidemiology and Toxicology Division at (800)588-1248. What is Perchlorate? How does perchlorate get into the body? -1 Perchlorate (ClO4 ) is the most oxygenated member of Drinking water contaminated with perchlorate is the a series of compounds made up of chlorine and most likely way that perchlorate can get into the body. oxygen. It can form an acid or a salt in combination Perchlorate is not well absorbed through the skin. with a hydrogen ion (H+) or another cation such as sodium, potassium, or ammonium ion. Perchlorate What health effects are associated with salts, which have been widely used as an oxidizer in perchlorate? solid propellants for rockets and missiles since the mid- 1940s, have a finite shelf-life and must periodically be Perchlorate competitively inhibits the uptake of iodide replaced. As a result, large volumes of perchlorate by the thyroid gland through its effect on a transport have been disposed of since the 1950s. -
Determination of Thiamazole in Tablet Formulation by Using Reversed Phase Liquid Chromatographic Method
4th International Symposium on Innovative Approaches in Engineering and Natural Sciences SETSCI Conference November 22-24, 2019, Samsun, Turkey Proceedings https://doi.org/10.36287/setsci.4.6.146 4 (6), 512-515, 2019 2687-5527/ © 2019 The Authors. Published by SETSCI Determination of Thiamazole in Tablet Formulation by Using Reversed Phase Liquid Chromatographic Method Kader Poturcu1+, Ebru Çubuk Demiralay1* 1Arts & Science Faculty, Suleyman Demirel University, Isparta, Turkey *Corresponding author: [email protected] +Speaker: [email protected] Presentation/Paper Type: Oral / Full Paper Abstract – In this study, the amount of thiamazole (methimazole) in pharmaceutical tablet formulation was determined by using reversed phase liquid chromatography method (RPLC). Chromatographic separation was carried out by using YMC Triart C18 (150 mm × 4.6 mm, 3μm, YMC, USA) column. 5% (v/v) acetonitrile-water binary mixture at pH 9.5 was used as a mobile phase. Metronidazole was chosen as an internal standard. Flow rate was 0.8 ml/min and column temperature was 25 °C in chromatographic separation. The studied wavelengths for thiamazole and metronidazole are 260 and 340 nm, respectively. This proposed method was suitably validated with respect to accuracy, precision, linearity, the limit of detection (LOD) and limit of quantification (LOQ). The calibration graph of thiamazole was linear from 4 ppm to 14 ppm. The recovery of the 5 mg thiamazole containing commercial tablet (Thyromazol) was 100.059%. The proposed RPLC method was successfully applied to the determination of thiamazole in commercial tablet formulation. Keywords –Thiamazole, tablet formulation, RPLC method, method validation, recovery. I. INTRODUCTION In the last years thiamazole became also a fashioned model substance for endocrine disruption (thyroid axis) studies thus During the last decades, there has been increasing evidence inhibits the production of the thyroid hormones. -
Fate of Sodium Pertechnetate-Technetium-99M
JOURNAL OF NUCLEAR MEDICINE 8:50-59, 1967 Fate of Sodium Pertechnetate-Technetium-99m Dr. Muhammad Abdel Razzak, M.D.,1 Dr. Mahmoud Naguib, Ph.D.,2 and Dr. Mohamed El-Garhy, Ph.D.3 Cairo, Egypt Technetium-99m is a low-energy, short half-life iostope that has been recently introduced into clinical use. It is available as the daughter of °9Mowhich is re covered as a fission product or produced by neutron bombardement of molyb denum-98. The aim of the present work is to study the fate of sodium pertechnetate 9OmTc and to find out any difference in its distribution that might be caused by variation in the method of preparation of the parent nuclide, molybdenum-99. MATERIALS & METHODS The distribution of radioactive sodium pertechnetate milked from 99Mo that was obtained as a fission product (supplied by Isocommerz, D.D.R.) was studied in 36 white mice, weighing between 150 and 250 gm each. Normal isotonic saline was used for elution of the pertechnetate from the radionuclide generator. The experimental animals were divided into four equal groups depending on the route of administration of the radioactive material, whether intraperitoneal, in tramuscular, subcutaneous or oral. Every group was further subdivided into three equal subgroups, in order to study the effect of time on the distribution of the pertechnetate. Thus, the duration between administration of the radio-pharma ceutical and sacrificing the animals was fixed at 30, 60 and 120 minutes for the three subgroups respectively. Then the animals were dissected and the different organs taken out.Radioactivityin an accuratelyweighed specimen from each organ was estimated in a scintillation well detector equipped with one-inch sodium iodide thallium activated crystal. -
Package Insert TECHNETIUM Tc99m GENERATOR for the Production of Sodium Pertechnetate Tc99m Injection Diagnostic Radiopharmaceuti
NDA 17693/S-025 Page 3 Package Insert TECHNETIUM Tc99m GENERATOR For the Production of Sodium Pertechnetate Tc99m Injection Diagnostic Radiopharmaceutical For intravenous use only Rx ONLY DESCRIPTION The technetium Tc99m generator is prepared with fission-produced molybdenum Mo99 adsorbed on alumina in a lead-shielded column and provides a means for obtaining sterile pyrogen-free solutions of sodium pertechnetate Tc99m injection in sodium chloride. The eluate should be crystal clear. With a pH of 4.5-7.5, hydrochloric acid and/or sodium hydroxide may have been used for Mo99 solution pH adjustment. Over the life of the generator, each elution will provide a yield of > 80% of the theoretical amount of technetium Tc99m available from the molybdenum Mo99 on the generator column. Each eluate of the generator should not contain more than 0.0056 MBq (0.15 µCi) of molybdenum Mo99 per 37 MBq, (1 mCi) of technetium Tc99m per administered dose at the time of administration, and not more than 10 µg of aluminum per mL of the generator eluate, both of which must be determined by the user before administration. Since the eluate does not contain an antimicrobial agent, it should not be used after twelve hours from the time of generator elution. PHYSICAL CHARACTERISTICS Technetium Tc99m decays by an isomeric transition with a physical half-life of 6.02 hours. The principal photon that is useful for detection and imaging studies is listed in Table 1. Table 1. Principal Radiation Emission Data1 Radiation Mean %/Disintegration Mean Energy (keV) Gamma-2 89.07 140.5 1Kocher, David C., “Radioactive Decay Data Tables,” DOE/TIC-11026, p. -
Gold Dissolution in Acid Thiourea-Thiocyanate Solutions Using Ferric As Oxidant
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by The University of Utah: J. Willard Marriott Digital Library University of Utah Institutional Repository Author Manuscript Thiourea-thiocyanate leaching system for gold a b b b a Xiyun Yang , Michael S. Moats , Jan D. Miller , Xuming Wang , Xichang Shi , a Hui Xu a UU IR Author Manuscript School of Metallurgical Science and Engineering, Central South University, Hunan 410083, China bDepartment of Metallurgical Engineering, College of Mines and Earth Sciences, University of Utah, Salt Lake City, Utah 84112, USA Abstract: The leaching of gold in thiourea-thiocyanate solutions has been studied by the rotating-disk technique using ferric sulfate as oxidant. The effects of initial concentrations of ferric, thiourea (Tu) and thiocyanate as well as temperature and pH values on gold leaching rates were studied. An initial gold leaching rate in the order of -9 -2 -1 10 mol cm s was obtained at 25℃, which was higher than rates obtained when either ferric-thiocyanate or ferric-thiourea solutions were used separately. The synergistic effect was attributed to the formation of a mixed ligand complex UU IR Au(Tu)2SCN. Determinations of apparent activation energy indicate that the process was controlled by a combination of chemical reaction and diffusion in the mixed lixiviant system. Open circuit potentials show that thiocyanate stability is increased in Author Manuscript the mixture. Keywords: Gold dissolution; Thiourea; Thiocyanate; Synergistic effect 1. Introduction Corresponding author:Tel.:+86 731 88877352; fax:+86 731 88710171 E-mail address:[email protected](Xiyun Yang) University of Utah Institutional Repository Author Manuscript A possible alternative reagent to cyanide for gold leaching is thiocyanate, as first reported by White (1905). -
Survey of the Actual Administration of Thiamazole for Hyperthyroidism in Japan by the Japan Thyroid Association
doi:10.1507/endocrj.EJ21-0238 Original Survey of the actual administration of thiamazole for hyperthyroidism in Japan by the Japan Thyroid Association Natsuko Watanabe, Jaeduk Yoshimura Noh, Takashi Akamizu, Masanobu Yamada and the study group members of the Japan Thyroid Association The Japan Thyroid Association, Tokyo, Japan Abstract. To clarify the actual administration of thiamazole (MMI), the first choice of antithyroid drugs, the actual therapy provided by the Japan Thyroid Association (JTA) members for the following conditions was surveyed. The subjects included adult patients, pregnant women, and pediatric patients with Graves’ disease who visited each medical institution from September 2019 to February 2020. Initial doses, frequency of administration, maintenance doses, maximum doses, consultation intervals for pregnant women, and dosages administrated to breastfeeding mothers were surveyed. The total number of cases collected was 11,663. Administration of 15 mg once a day was the most common initial therapy, constituted 74.4% (2,526/3,397 cases) of adults, 33.8% (44/130) of pregnant women, and 50.8% (61/120) of children. The maintenance dose before discontinuation was equivalent to 2.5 mg/day in 52.3% (3,147/6,015). The most common maximum dose for adults and children was 30 mg/day, administrated to 57.5% of adults (223/388) and 59.6% (28/47) of children; for pregnant women, it was 15 mg/day, administrated to 71.1% (27/38). The most common consultation interval for pregnant women was every four weeks (32.1%, 341/1,063). In lactating mothers, the dose was 10 mg/day or less in 366 of 465 cases (78.7%). -
Resistance to Thyroid Hormone with a Mutation of the Thyroid B Receptor
Case report/opis przypadku Endokrynologia Polska DOI: 10.5603/EP.a2018.0082 Tom/Volume 70; Numer/Number 1/2019 ISSN 0423–104X Resistance to thyroid hormone with a mutation of the thyroid b receptor gene in an eight-month-old infant — a case report Zespół oporności na hormony tarczycy spowodowany mutacją w genie kodującym podjednostkę b receptora hormonów tarczycy u 8-miesięcznego niemowlęcia: opis przypadku Elżbieta Foryś-Dworniczak, Carla Moran, Barbara Kalina-Faska, Ewa Małecka-Tendera, Agnieszka Zachurzok Department of Paediatrics and Paediatric Endocrinology, School of Medicine in Katowice, Katowice, Poland Abstract Introduction: Resistance to thyroid hormone (RTHb) is a rare syndrome of impaired tissue responsiveness to thyroid hormones (THs). The disorder has an autosomal dominant or recessive pattern of inheritance. Most of the reported mutations have been detected in the thyroid hormone receptor b gene (THRB). Case report: Authors present an eight-month-old infant with poor linear growth, decreased body weight, tachycardia, positive family history, and neonatal features suggestive of RTHb. Both our patient and his mother had elevated free thyroxine, free triiodothyronine, and non-suppressed thyrotropin (TSH) concentration. The fluorescent sequencing analysis showed a heterozygous mutation c.728G>A in TRb gene. This pathogenic variant is known to be associated with THR. Conclusions: The clinical presentation of RTHb is variable, ranging from isolated biochemical abnormalities to symptoms of thyrotoxicosis or hypothyroidism. The -
Thyroid Hormone Regulation of Mrnas Encoding Thyrotropin β-Subunit, Glycoprotein Î
Thyroid hormone regulation of mRNAs encoding thyrotropin b-subunit, glycoprotein a-subunit, and thyroid hormone receptors a and b in brain, pituitary gland, liver, and gonads of an adult teleost, Pimephales promelas Sean C Lema, Jon T Dickey , Irvin R Schultz and Penny Swanson Abstract Thyroid hormones (THs) regulate growth, morphological transcript levels for TR isoforms a and b (tra and trb) in the development, and migratory behaviors in teleost fish, yet liver and brain, but reduced levels of brain mRNA for the little is known about the transcriptional dynamics of gene immediate-early gene basic transcription factor-binding targets for THs in these taxa. Here, we characterized TH protein (bteb). In the ovary and testis, exogenous T3 elevated regulation of mRNAs encoding thyrotropin subunits and gene transcripts for tshb, glycoprotein hormone a-subunit thyroid hormone receptors (TRs) in an adult teleost fish ( gpha), and trb, while not affecting tra levels. Taken model, the fathead minnow (Pimephales promelas). Breeding together, these results demonstrate negative feedback of T4 pairs of adult minnows were fed diets containing 3,5, on pituitary tshb, identify tra and trb as T3-autoinduced 0 3 -triiodo-L-thyronine (T3) or the goitrogen methimazole genes in the brain and liver, and provide new evidence for 10 days. In males and females, dietary intake of that tshb, gpha, and trb are THs regulated in the gonad of exogenous T3 elevated circulating total T3, while methima teleosts. Adult teleost models are increasingly used to zole depressed plasma levels of total thyroxine (T4). In both evaluate the endocrine-disrupting effects of chemical sexes, this methimazole-induced reduction in T4 led to contaminants, and our results provide a systemic assessment elevated mRNA abundance for thyrotropin b-subunit (tshb) of TH-responsive genes during that life stage. -
Neo-Mercazole
NEW ZEALAND DATA SHEET 1 NEO-MERCAZOLE Carbimazole 5mg tablet 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains 5mg of carbimazole. Excipients with known effect: Sucrose Lactose For a full list of excipients see section 6.1 List of excipients. 3 PHARMACEUTICAL FORM A pale pink tablet, shallow bi-convex tablet with a white centrally located core, one face plain, with Neo 5 imprinted on the other. 4 CLINICAL PARTICULARS 4.1 Therapeutic indications Primary thyrotoxicosis, even in pregnancy. Secondary thyrotoxicosis - toxic nodular goitre. However, Neo-Mercazole really has three principal applications in the therapy of hyperthyroidism: 1. Definitive therapy - induction of a permanent remission. 2. Preparation for thyroidectomy. 3. Before and after radio-active iodine treatment. 4.2 Dose and method of administration Neo-Mercazole should only be administered if hyperthyroidism has been confirmed by laboratory tests. Adults Initial dosage It is customary to begin Neo-Mercazole therapy with a dosage that will fairly quickly control the thyrotoxicosis and render the patient euthyroid, and later to reduce this. The usual initial dosage for adults is 60 mg per day given in divided doses. Thus: Page 1 of 12 NEW ZEALAND DATA SHEET Mild cases 20 mg Daily in Moderate cases 40 mg divided Severe cases 40-60 mg dosage The initial dose should be titrated against thyroid function until the patient is euthyroid in order to reduce the risk of over-treatment and resultant hypothyroidism. Three factors determine the time that elapses before a response is apparent: (a) The quantity of hormone stored in the gland. (Exhaustion of these stores usually takes about a fortnight). -
Thyroid Crisis Following Interstitial Nephritis
□ CASE REPORT □ Thyroid Crisis following Interstitial Nephritis Toshio Kahara 1, Miyako Yoshizawa 1, Izaya Nakaya 1, Akio Uchiyama 2,AtsuoMiwa2, Yasunori Iwata 1, Muneyoshi Torita 1, Rika Usuda 1 and Hiroyuki Iida 1 Abstract A 54-year-old man with Graves’ disease had been treated with thiamazole (5 mg/day). His thyroid hor- mone level was increased after exodontia in February 2006. Although his prescribed dose of thiamazole was increased after exodontia on the fourth day, he developed thyroid crisis on exodontia 52nd day. Laboratory findings also showed renal dysfunction (from Cr 1.0 mg/dL in July 2005 to Cr 1.8 mg/dL on exodontia 37th day). His thyroid hormone level was normalized after subtotal thyroidectomy; however, serum Cr level was still high. He was diagnosed with interstitial nephritis as a result of renal biopsy, and he was treated with prednisolone 30 mg/day. This present case developed thyroid crisis even though the quantity of thiamazole was increased after exodontia. It seems that interstitial nephritis, as well as exodontia, is an aggravation fac- tor of thyroid function. After a poor response to anti-thyroid drugs, it is necessary to prevent thyroid crisis by determining the aggravating factor and to then provide appropriate treatment. Key words: interstitial nephritis, thyroid crisis, hyperthyroidism, Graves’ disease (Inter Med 47: 1237-1240, 2008) (DOI: 10.2169/internalmedicine.47.0947) 4.7% are due to tubulointerstitial nephritis and uveitis syn- Introduction drome (TINU) (2). There are case reports of transient hyper- thyroidism in TINU (3, 4), and interstitial nephritis may Thyroid crisis is defined as thyroid function that is ex- contribute to aggravation of the thyroid function. -
Perchlorates
Oregon Department of Human Services Office of Environmental Public Health (503) 731-4030 Emergency 800 NE Oregon Street #604 (971) 673-0405 Portland, OR 97232-2162 (971) 673-0457 FAX (971) 673-0372 TTY-Nonvoice TECHNICAL BULLETIN HEALTH EFFECTS INFORMATION Prepared by: ENVIRONMENTAL TOXICOLOGY SECTION March, 2004 PERCHLORATES For More Information Contact: Environmental Toxicology Section (971) 673-0440 Drinking Water Section (971) 673-0405 Technical Bulletin-Health Effects Information Perchlorates Page 2 SYNONYMS Perchlorate Ion, Perchlorate Salts, Perchloric Acid. Examples of perchlorate salts are Sodium Perchlorate, Ammonium Perchlorate, Potassium Perchlorate.Do not confuse with chlorates. USES Perchlorate ion and perchlorate salts are used extensively in industry in the production of military explosives, rocket and missile fuels, fireworks, flares, matches, dyes, lubricants, paints, rubber products and pharmaceuticals. Perchlorates are also used in leather tanning and in electroplating.Perchlorate ion, perchloric acid and perchlorate salts are strong oxidizers, but perchlorate ion has a very high activation temperature, so it can persist in products and in the environment for decades. Perchlorates are natural ingredients in some natural soils and mineral formations.Perchlorate salts are present in some naturally mined nitrate and phosphate fertilizers, particularly rock fertilizers from Chile. Historically perchlorate compounds have had some use as medications in treating persons with overly-active thyroid glands, but this use has -
Liothyronine Sodium(BANM, Rinnm) Potassium Perchlorate
2174 Thyroid and Antithyroid Drugs with methodological limitations. However, a controlled trial of In myxoedema coma liothyronine sodium may be liothyronine with paroxetine could not confirm any advantage of given intravenously in a dose of 5 to 20 micrograms by 3 O additive therapy. slow intravenous injection, repeated as necessary, usu- 1. Aronson R, et al. Triiodothyronine augmentation in the treat- HO I ally at intervals of 12 hours; the minimum interval be- ment of refractory depression: a meta-analysis. Arch Gen Psychi- OH atry 1996; 53: 842–8. tween doses is 4 hours. An alternative regimen advo- 2. Altshuler LL, et al. Does thyroid supplementation accelerate tri- NH2 cates an initial dose of 50 micrograms intravenously cyclic antidepressant response? A review and meta-analysis of I O the literature. Am J Psychiatry 2001; 158: 1617–22. followed by further injections of 25 micrograms every 3. Appelhof BC, et al. Triiodothyronine addition to paroxetine in I 8 hours until improvement occurs; the dosage may the treatment of major depressive disorder. J Clin Endocrinol then be reduced to 25 micrograms intravenously twice Metab 2004; 89: 6271–6. (liothyronine) daily. Obesity. Thyroid drugs have been tried in the treatment of obes- Liothyronine has also been given in the diagnosis of ity (p.2149) in euthyroid patients, but they produce only tempo- NOTE. The abbreviation T3 is often used for endogenous tri-io- hyperthyroidism in adults. Failure to suppress the up- rary weight loss, mainly of lean body-mass, and can produce se- dothyronine in medical and biochemical reports. Liotrix is USAN rious adverse effects, especially cardiac complications.1 for a mixture of liothyronine sodium with levothyroxine sodium.