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Epigenetics of Neural Plasticity in Neurodegenerative Disorders

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Epigenetics of Neural Plasticity in Neurodegenerative Disorders Neural Plasticity Special Issue on Epigenetics of Neural Plasticity in Neurodegenerative Disorders CALL FOR PAPERS We invite the submission of original research articles for our special issue that Lead Guest Editor broadly covers the epigenetics of brain function. e eld of epigenetics encompasses Amul J. Sakharkar, Savitribai Phule the study of gene expression regulation without changes in DNA sequence. Gen- Pune University, Pune, India erally, these mechanisms are limited to chromatin architecture alterations aecting [email protected] transcription factor gene promoter access and noncoding RNA. Guest Editors e last couple of decades have witnessed enormous growth in our understanding of David P. Gavin, University of Illinois at these complex epigenetic pathways and their ability to regulate diverse fundamental Chicago, Chicago, USA biological functions. [email protected] e appeal of the hypothesis that aberrant epigenetic mechanisms play prominent Shashank Dravid, Creighton University, roles in brain development as well as neuropsychiatric disorders is that they are Omaha, USA inuenced by the underlying generally immutable linear DNA sequence, sensitive [email protected] to environmental factors, and highly stable. Neuronal development, learning, psychological stress, drugs of abuse, and psychiatric medications manifestations Nishikant Subhedar, Indian Institute of have been shown to be largely encoded through epigenetic alterations in dierent Science Education and Research parts of the brain. Not surprisingly abnormalities in these pathways have been (IISER), Pune, India reported in various neurodegenerative disorders, including depression, anxiety, [email protected] schizophrenia, and Alzheimer’s disease, among others. Technological developments and the availability of resources to study epigenetics are giving new dimensions and Marina Guizzetti, Oregon Health & posing new challenges to our current understandings about the potential of these Science University, Portland, USA mechanisms in regulating crucial neural circuits. [email protected] We are seeking contributions related to the mechanisms underlying enzymatic activ- Manuscript Due ity regulation, posttranslational modications, ability to inuence target gene tran- Friday, January òýÔâ scription and alter nucleic acid structure, proteomics and epigenomics approaches, and epigenetic transgenerational inheritance involved in the neurodegenerative First Round of Reviews disorders. Original, high quality contributions that are not yet published or that Friday, Ô April òýÔâ are not currently under review by other journals or peer-reviewed conferences are sought. Publication Date Friday, òÞ May òýÔâ Potential topics include, but are not limited to: Chromatin remodelling regulating synaptic plasticity DNA methylation and histone covalent modications in neural function miRNAs and noncoding RNAs in reprogramming gene networks Noncoding RNA and chromatin remodelling cross talk Chromatin protein PTMs in transcription Epigenetic regulation of neuronal proteomics in neurodegeneration Technologies of neuroepigenetic studies Clinical developments in epigenetics of neurodegeneration erapeutic and biomarker studies in neuroepigenetics Authors can submit their manuscripts via the Manuscript Tracking System at http://mts.hindawi.com/submit/journals/np/enp/..
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