CEEHRC NETWORK Canadian Epigenetics, Environment and Health Research Consortium Network THE 5TH CANADIAN CONFERENCE ON EPIGENETICS 30 September – 3 October 2018 Estérel Resort, Estérel, Québec, Canada MEETING PROGRAM EPIGENETICS CANADA CEEHRC NETWORK Welcome! Canadian Epigenetics, Environment and Health Research Consortium Network Welcome! Dear Colleagues, It is a pleasure to welcome you to Estérel Resort for the 5th Canadian Conference on Epigenetics. This year is our largest meeting to date bringing together over 200 Canadian epigenetics researchers, along with key international leaders in the field, to engage in cross-disciplinary dialogue on the state of epigenetics research in Canada and beyond. The scientific program includes distinguished invited speakers in the fields of epigenetics and epigenomics covering topics including cancer epigenetics, neuroepigenetics, chromatin organization, epigenetic regulation in the immune system and during development, and new developments and advancements in epigenomics technology. These topics will be covered over 9 sessions that include plenary lectures and short oral presentations, a computational epigenetics workshop, and 2 poster sessions. We hope that the meeting format will encourage interaction and networking between young scientists and Principal Investigators while providing an atmosphere that stimulates scientific debate and catalyzes new collaborations. This year continues our tradition of organizing this meeting as a collaboration between the Canadian Epigenetics, Environment and Health Research Consortium (CEEHRC) Network and the “Epigenetics, EH!” conference series. The aim of the CEEHRC Network is to connect Canadian epigenetics researchers and expand their reach to the broader health research community in Canada and beyond. The CEEHRC Network also facilitates access to state-of-the- science epigenomic mapping capacity and curated reference human epigenomic datasets; produces and curates epigenetic and epigenomics tools, software and protocols; and curates Canadian jobs, training opportunities, and events relevant to the epigenetics community. More information is available at www.epigenomes.ca. We welcome your feedback on what you’d like to see from future meetings, and from the CEEHRC Network more broadly. On behalf of the Organizing Committee, we wish you a warm welcome to Estérel. Sincerely, Martin Hirst, PhD Head, Epigenomics BC Cancer Genome Sciences Centre Director, Canadian Epigenetics, Environment and Health Research Consortium Network Associate Director, Michael Smith Laboratories Associate Professor, Department of Microbiology & Immunology University of British Columbia 2 CEEHRC NETWORK Table of Contents Canadian Epigenetics, Environment and Health Research Consortium Network Table of Contents Welcome! 2 Organizing Committee 4 Speakers Keynote 5 Invited Speakers 6 Selected Talks 8 Rapid Fire Talks 10 Epigenetic Technologies 10 Program Agenda 11 Poster Assignments 15 Sponsors 16 Map of Estérel Resort 17 Abstracts 18 List of Attendees 68 3 CEEHRC NETWORK Organizing Committee Canadian Epigenetics, Environment and Health Research Consortium Network Organizing Committee Cheryl Arrowsmith Nathalie Bérubé Steve Bilodeau Guillaume Bourque University of Toronto Western University Université Laval McGill University Marjorie Brand Carolyn Brown Steven Jones Martin Hirst Ottawa Hospital University of British BC Cancer University of British Research Institute Columbia Columbia Sarah Kimmins Serge McGraw Sinéad Aherne Tony Kwan McGill University Université de Montréal BC Cancer McGill University 4 CEEHRC NETWORK Speakers Canadian Epigenetics, Environment and Health Research Consortium Network Keynote Speaker Cigall Kadoch Assistant Professor, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Broad Institute Dr. Kadoch established her independent laboratory in 2014, at age 28, one of the youngest scientists ever appointed to the Harvard Medical School faculty, immediately following completion of her Ph.D. studies in Cancer Biology at Stanford University working with developmental biologist Gerald Crabtree. She has quickly become a leading expert in chromatin and gene regulation and is internationally recognized for her groundbreaking studies in these areas. Specifically, her laboratory studies the structure and function of chromatin remodeling complexes such as the mammalian SWI/SNF (or BAF) complex, with emphasis on defining the mechanisms underlying cancer-specific perturbations. Of note, the recent surge in exome- and genome-wide sequencing efforts has unmasked the major, previously unappreciated contribution of these regulators to malignancy: indeed, the genes encoding subunits of mammalian SWI/SNF complexes are mutated in over 25% of human cancers. In addition to receiving numerous prestigious awards and research grants to support her academic laboratory at Harvard, including the NIH Director’s New Innovator Award, the Pew Scholar Award, and the American Cancer Society Research Scholar Award, she was named on the Forbes 2014 30 Under 30 list, MIT Technology Review 35 Innovators Under 35, Popular Science Brilliant 10 of 2016 and most recently, Business Insider’s Top 30 Young Leaders in Biopharma. 5 CEEHRC NETWORK Speakers Canadian Epigenetics, Environment and Health Research Consortium Network Invited Speakers Luis Barreiro received his undergraduate Annie Vogel Ciernia obtained and Master’s degrees in Biotechnology at undergraduate degrees from North Lusófona University, Lisbon, Portugal. In Dakota State University in Biotechnology 2008, he obtained his PhD in Human and Psychology. She then completed her Population Genetics from the University of PhD work with Dr. Marcelo Wood at the Paris VII, followed by a post-doc in the University of California, Irvine and Department of Human Genetics at the postdoctoral training with Dr. Janine University of Chicago. From 2011 to 2018 LaSalle and Dr. Jacqueline Crawley as an Luis Barreiro he was Professor at the Université de Annie Ciernia Autism Research Training Fellow the Montréal, and a researcher at the CHU University of California, Davis. Dr. Vogel Associate Sainte-Justine. He is currently an Vogel Ciernia’s current research combines her Professor, Genetics Associate Professor in the Genetics Assistant interests in epigenomic regulation, neural- Division, University division, at the University of Chicago. His Professor, immune interactions, and animal behavior of Chicago work has been pioneering at using Department of to study gene regulatory mechanisms in population genomic data to characterize Biochemistry and brain development and the genetic basis of inter-individual Molecular BioloGy, neurodevelopmental disorders. differences in immune response to Center for Brain infectious agents. Health Dr. Classon has extensive experience in Dr. Josée Dostie is an Associate cancer biology in both academia and Professor in the Department of industry. Her research in recent years has Biochemistry at McGill. She is also an been focused on evaluating mechanisms associate member of the Goodman underlying epigenetically mediated cancer Cancer Research Center. Dr. Dostie cell drug tolerance. received her Ph.D. degree in 2000 from the Biochemistry department at McGill. She completed post-doctoral training at the University of Pennsylvania (2004) and Marie Classon Josée Dostie the University of Massachusetts (2007). Associate Her research program aims to understand Professor, the relationship between three- Department of dimensional genome organization, Biochemistry and epigenomics, and transcription activity. Rosalind & Morris Goodman Cancer Research Centre Susan Fisher, PhD, is a Professor in the Nicole Francis is an Associate Research Dept. of Obstetrics, Gynecology and Professor at the Montreal Clinical Reproductive Sciences, School of Research Institute (IRCM) and in the Medicine, University of California, San Biochemistry department at the Université Francisco. She is jointly appointed in the de Montréal, and the director of the Dept. of Anatomy. Dr. Fisher is the Biochemistry of Epigenetic Inheritance Director of the UCSF Human Embryonic research unit at the IRCM. The Francis lab Stem Cell Program and Faculty Director of is interested in how chromatin-based the Sandler-Moore Mass Spectrometry information can be propagated through Susan Fisher Core Facility. She and her group study Nicole Francis DNA replication and mitosis and uses Professor, human embryonic development and the Associate Research predominantly in vitro reconstitution University of biology/immunology of the human Professor, Dept of approaches to understand these California, San placenta in normal pregnancy and in Biochemsitry and questions. Francisco pathological situations, such as Molecular Medicine, preeclampsia and preterm birth. They also Institut de use mass spectrometry-based recherches approaches for comparative proteomic cliniques de analyses, including post-translational Montréal (IRCM) modifications. and Université de Montréal 6 CEEHRC NETWORK Speakers Canadian Epigenetics, Environment and Health Research Consortium Network Dr. Franklin was a post-doc in the lab of Michael Hoffman creates predictive Dr. Cornelius Gross (European Molecular computational models to understand Biology Laboratory) and she obtained her interactions between genome, epigenome, Ph.D. from the Swiss Federal Institute of and phenotype in human cancers. He Technology (ETH-Z) under the supervision implemented the genome annotation of Dr. Isabelle