Title Treatment response in depressed patients with enhanced Ca mobilization stimulated by serotonin Author(s) Kusumi, Ichiro; Suzuki, Katsuji; Sasaki, Yuki; Kameda, Kensuke; Koyama, Tsukasa Neuropsychopharmacology, 23(6), 690-696 Citation https://doi.org/10.1038/sj.npp.1395557 Issue Date 2000-12 Doc URL http://hdl.handle.net/2115/8436 Type article (author version) File Information NPP.pdf Instructions for use Hokkaido University Collection of Scholarly and Academic Papers : HUSCAP revised to Neuropsychopharmacology Treatment response in depressed patients with enhanced Ca mobilization stimulated by serotonin Ichiro Kusumi, M.D., Ph.D., Katsuji Suzuki, M.D., Yuki Sasaki, B.Sc., Kensuke Kameda, M.D.,Ph.D., and Tsukasa Koyama, M.D., Ph.D. Department of Psychiatry, Hokkaido University School of Medicine North 15, West 7, Sapporo 060-8638, Japan Running title: Treatment response and Ca mobilization Correspondence: Ichiro Kusumi, M.D., Ph.D. TEL: +81-11-716-1161 ext.5973 FAX: +81-11-736-0956 e-mail:
[email protected] 1 ABSTRACTS Serotonin (5-HT)-stimulated intraplatelet calcium (Ca) mobilization has been shown to be enhanced in nonmedicated depressive patients by many studies. However, there has not been any longitudinal follow-up study of this parameter. We examined the relationship between treatment response and pretreatment value of the 5-HT-induced Ca response. The 5-HT(10 uM)- induced intraplatelet Ca mobilization was measured in 98 nonmedicated depressive patients (24 bipolar disorders, 51 melancholic major depressive disorder and 23 non-melancholic major depressive disorder). These patients were followed up prospectively for a further period of 5 years. The depressed patients with enhanced Ca response to 5-HT in bipolar disorders exhibited a good response to mood stabilizers but those in major depressive disorders showed a poor response to antidepressants.