Chance between holism and reductionism: Tensions in the conceptualisation of Life Charles Wolfe To cite this version: Charles Wolfe. Chance between holism and reductionism: Tensions in the conceptualisation of Life. Progress in Biophysics and Molecular Biology, Elsevier, 2012, Chance at the heart of the cell, 110 (1), pp.113-120. 10.1016/j.pbiomolbio.2012.05.005. hal-01233183 HAL Id: hal-01233183 https://hal.archives-ouvertes.fr/hal-01233183 Submitted on 24 Nov 2015 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Chance between holism and reductionism: tensions in the conceptualisation of Life Charles T. Wolfe Centre for History of Science, Department of Philosophy and Moral Sciences, University of Ghent Blandijnberg 2, B-9000 Ghent T +32 9264 3952, F +32 9264 4187
[email protected] Abstract In debates between holism and reductionism in biology, from the early twentieth century to more recent re-enactments involving genetic reductionism, developmental systems theory, or systems biology, the role of chance – the presence of theories invoking chance as a strong explanatory principle – is hardly ever acknowledged. Conversely, Darwinian models of chance and selection (Dennett 1995, Kupiec 1996, Kupiec 2009) sit awkwardly with reductionist and holistic concepts, which they alternately challenge or approve of.