MAPK11 Antibody Cat. No.: 62-959

MAPK11 Antibody

Western blot analysis in K562 cell line lysates (35ug/lane).

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human, Mouse

This MAPK11 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 133-161 amino acids from the Central region of human MAPK11.

TESTED APPLICATIONS: WB

APPLICATIONS: For WB starting dilution is: 1:1000

PREDICTED MOLECULAR 41 kDa WEIGHT:

October 1, 2021 1 https://www.prosci-inc.com/mapk11-antibody-62-959.html Properties

This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: MAPK11

Mitogen-activated protein kinase 11, MAP kinase 11, MAPK 11, Mitogen-activated protein ALTERNATE NAMES: kinase p38 beta, MAP kinase p38 beta, p38b, Stress-activated protein kinase 2b, SAPK2b, p38-2, MAPK11, PRKM11, SAPK2, SAPK2B

ACCESSION NO.: Q15759

PROTEIN GI NO.: 134047835

GENE ID: 5600

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

P38 beta is a member of the MAP kinase subfamily of Ser/Thr protein kinases. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by changes in osmolarity of the extracellular environment, BACKGROUND: proinflammatory cytokines and cellular stress. This protein preferentially phosphorylates transcription factor ATF2. It is activated by phosphorylation on threonine and tyrosine by MKK6, and inhibited by pyridinyl-imidazole related compounds. Highest levels of expression are found in the brain and heart, with additional expression in the placenta, lung, liver, skeletal muscle, kidney and pancreas.

REFERENCES: 1) Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).

2) Dunham, I., et al., Nature 402(6761):489-495 (1999).

October 1, 2021 2 https://www.prosci-inc.com/mapk11-antibody-62-959.html 3) Enslen, H., et al., J. Biol. Chem. 273(3):1741-1748 (1998).

4) Kumar, S., et al., Biochem. Biophys. Res. Commun. 235(3):533-538 (1997).

ANTIBODIES FOR RESEARCH USE ONLY.

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