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Copyrighted Material 127 Index Note: Page numbers in italic refer to figures, those in bold refer to tables. 7.1 see NG2 acute mixed phenotype with t(6;9) 52 α (alpha) 39 leukaemia see mixed with t(8;21)(q22;q22.1) 54, γ (gamma) 39 phenotype acute leukaemia 55, 93, 112 δ (delta) 39 acute monoblastic leukaemia, with t(9;11) or other KMT2A ε (epsilon) 39 case 102, 118–119 rearranged 52 κ (kappa) 38 acute monoblastic/monocytic acute promyelocytic leukaemia, λ (lambda) 38 leukaemia 33 with t(15;17)(q24.1;q21.2) μ (mu) 39 acute monocytic leukaemia, 48–52, 54, 93, 112 case 100, 116–118 acute undifferentiated a acute myeloid leukaemia leukaemia (AUL) 62 abbreviations ix–x, 47, 89 (AML) 48 case 108, 123 acute basophilic leukaemia associated with Down’s adult T‐cell leukaemia/ 14, 36, 55 syndrome 28, 55 lymphoma (ATLL) 74, acute lymphoblastic leukaemia with bi‐allelic CEBPA 92, 94, 112, 113 (ALL) 55–62, 90, 111 mutation 55 aggressive NK‐cell see also B‐lineage acute case 98, 115 leukaemia 76, 91, 111 lymphoblastic leukaemia immunophenotyping of alemtuzumab 27, 73 (B‐ALL) acute myeloid leukaemia ALK1 see CD246 case 103, 119–120 and blastic plasmacytoid ALK‐negative anaplastic large minimal residual disease dendritic cell cell lymphoma 75 (MRD) 77–78 neoplasm 53–54 ALK‐positive anaplastic large therapy‐related 103, 119–120 with inv(3) 52 cell lymphoma 75 T‐lineage acute lymphoblasticCOPYRIGHTED with inv(16) 12, 52, MATERIAL53 ALL see acute lymphoblastic leukaemia (T‐ALL) minimal residual disease leukaemia 60–62, 103–104, 119–120 (MRD) 78 AML see acute myeloid acute mast cell leukaemia with mutated NPM1 leukaemia 20, 23 92, 111 anaplastic large cell lymphoma acute megakaryoblastic with mutated RUNX1 55 75, 95, 113 leukaemia 15, 23, 25, 29, with myelodysplasia‐related case 105, 120 30, 53–54, 55 changes 55 angioimmunoblastic T‐cell with t(1;22)(p13.3;q13.1); not otherwise specified 55 lymphoma 74 RBM15‐MKL1 54, 93 with t(1;22) 92 annexin A1 39 Immunophenotyping for Haematologists: Principles and Practice, First Edition. Barbara J. Bain and Mike Leach. © 2021 John Wiley & Sons Ltd. Published 2021 by John Wiley & Sons Ltd. bindex.indd 127 01-09-2020 18:39:03 128 Index antigen expression during BCL6 39 CD4 13 maturation of the B‐ BCL10 39 CD5 13 lymphocyte lineage in the Bernard–Soulier syndrome CD7 13–14 bone marrow and in 6, 25 CD8 14 peripheral lymphoid blastic plasmacytoid dendritic CD9 14 tissues 51 cell neoplasm 65 CD10 14–15 antigen expression during case 101, 117 CD11a 15 maturation of the blinatumomab 12–13, 17 CD11b 15 erythroid lineage in the B‐lineage acute lymphoblastic CD11c 15 bone marrow 51 leukaemia (B‐ALL) CD13 15–16 antigen expression during 55–60, 90, 111 CD14 16 maturation of the monocyte BCR‐ABL1‐like 56, 57 CD15 16–17 lineage in the bone marrow with high hyperdiploidy 33, CD16 17 and, in tissues, to 55–57 CD19 17 macrophages 50 with t(1;19) 37, 59 CD19 expression, antigen expression during with t(4;11) 34, 57, 111 flow cytometric maturation of the with t(9;22) 57 immunophenotyping neutrophil lineage within with t(12;21) 57 3, 4, 5 the bone marrow 50 B‐lineage neoplasms, mature CD20 17–18 antigen expression during see mature B‐lineage CD21 18 maturation of the T‐ neoplasms CD22 18–19 lymphocyte lineage in the B‐lineage non‐Hodgkin CD23 19 bone marrow, thymus and lymphoma, minimal CD24 19 peripheral lymphoid residual disease CD25 19–20 tissues 52 (MRD) 78 CD26 20 atezolizumab 37 blood grouping 27 CD27 20 ATLL see adult T‐cell B lymphocyte 49, 51, 55, 56 CD28 21 leukaemia/lymphoma BOB.1 40 CD30 21 atypical chronic myeloid BRAFV600E 40 CD31 21–22 leukaemia 35, 63 brentuximab vedotin CD32 22 AUL see acute undifferentiated (auristatin) 21 CD33 22 leukaemia Burkitt lymphoma 69, 91, 111 CD34 22–23 auristatin (brentuximab CD34 expression, flow cytometric vedotin) 21 c immunophenotyping autoimmune calprotectin 40 3, 4–5 lymphoproliferative camidanlumab tesirine 20 CD35 23 syndrome 6, 28 camrelizumab 37 CD36 23 avelumab 37 carcinoembryonic antigen see CD37 23–24 axicabtagene ciloleucel 17 CD66a‐e CD38 24 carcinoma, metastatic 95, 113 CD40 24 b case 99, 115 CD41a 24–25 B‐ALL see B‐lineage acute CAR T cell see chimaeric CD41b 25 lymphoblastic leukaemia antigen receptor T cell CD42a 25 basiliximab 20 Castleman disease 21 CD42b 25 basogranulin 39 CD1 12 CD42c 25 basophil 42, 49 CD2 12 CD42d 25 BCL2 39 CD3 12–13 CD43 25–26 bindex.indd 128 01-09-2020 18:39:03 Index 129 CD44 26 CD203c 36 cluster of differentiation (CD) CD45 26 CD207 36 3, 7, 11 CD45 expression, CD227 36 CMML see chronic flow cytometric CD229 36 myelomonocytic leukaemia immunophenotyping 3–4 CD235a 36 cutaneous T‐cell lymphoma CD47 26–27 CD235b 36 23, 28, 35, 37 CD49b 27 CD236 36 cyclin D1 40 CD52 27 CD236R 36–37 cytokeratin 40 CD54 27 CD241 37 CD55 27 CD246 37 d CD56 27–28 CD269 37 dabrafenib 40 CD57 28–29 CD274 37 dacetuzumab 24 CD58 29 CD279 37 daclizumab 20 CD59 29 CD300e 37 daratumumab 24, 72 CD61 29 CD303 37 DBA.44 40 CD64 29–30 CD304 37–38 desmin 40 CD65 30 CD305 38 diffuse large B‐cell CD66a‐e 30 CD319 38 lymphoma 70 CD66e see CD66a‐e CD324 38 Down’s syndrome 15, 33, 53 CD68 30 CD326 38 acute myeloid leukaemia CD68R 30 CD335 38 (AML) 28, 55 CD71 30 CD340 38 transient abnormal CD79a 31 cemiplimab 37 myelopoiesis of Down’s CD79b 31 chimaeric antigen receptor T syndrome 15, 33, 53, 55, CD80 31 cell (CAR T cell) 12, 17, 96, 114 CD81 31 26, 34 durvalumab 37 CD86 31–32 chromogranin 40 CD94 32 chronic eosinophilic leukaemia e CD99 32 12, 19, 20 early T‐cell precursor acute CD103 32 chronic lymphocytic leukaemia lymphoblastic CD105 32 (CLL) 67 leukaemia 93 CD107a 32–33 case 93 early T‐cell precursor CD110 33 minimal residual disease lymphoblastic CD116 33 (MRD) 78 leukaemia 112 CD117 33 chronic lymphoproliferative E‐cadherin see CD324 CD123 33–34 disorder of NK cells 76 elotuzumab 38 CD127 34 chronic myeloid leukaemia, EMA see eosin‐5‐maleimide CD133 34 transformation, case endoglin see CD105 CD135 34 97, 114 endothelial cell 21 CD138 34 chronic myelomonocytic enteropathy‐associated T‐cell CD157 35 leukaemia (CMML) 13, lymphoma 21, 32, 75–76 CD158a‐k 35 16, 28, 62–64, 64 eosin‐5‐maleimide (EMA) 121 CD160 35 cirmtuzumab vedotin 44 eosinophil 49 CD161 35 classical Hodgkin lymphoma eosinophil major basic CD163 35 72, 73, 95, 113 protein 40 CD180 35–36 CLL see chronic lymphocytic eosinophil peroxidase 40 CD200 36 leukaemia Ep‐CAM see CD326 bindex.indd 129 01-09-2020 18:39:03 130 Index epithelial membrane antigen follicular T‐cell lymphoma 14 Hodgkin lymphoma see CD227 forward scatter (FSC), flow classical 72, 73, 95, 113 Erdheim–Chester disease cytometric nodular lymphocyte 40, 65 immunophenotyping predominant Hodgkin ERG 41 1–2, 3–5 lymphoma 72, 73 erythroblast 49 human T‐cell lymphotropic Ewing’s sarcoma 28, 32, 41 g virus 1 19–20 extranodal NK/T‐cell galiximab 31 lymphoma, nasal type 76 gemtuzumab ozogamicin 22 i genotype, immunophenotype ibalizumab 13 f correlation 48–55 ibritumomab tiuxetan 18 FLAER see fluorescent Glanzmann’s thrombasthenia immunoglobulin 41–42 aerolysin 6, 25, 27, 29 immunohistochemistry 7–8 FLI1 41 glycophorin see CD235a; immunophenotype, genotype flotetuzumab 34 CD235b; CD236; correlation 48–55 flow cytometric diagnosis, CD236R immunophenotype of cells of paroxysmal nocturnal glycosylphosphatidylinositol specific myeloid haemoglobinuria (GPI) 16, 78 lineages 48 78, 79 granzyme 41, 65, 75, 76 immunophenotyping of acute flow cytometric myeloid leukaemia and immunophenotyping h blastic plasmacytoid 1–7 haematogones, case dendritic cell CD19 expression 3, 4, 5 109–110, 124 neoplasm 53–54 CD34 expression 3, 4–5 haemophagocytic inotuzumab ozogamicin 18 CD45 expression 3–4 lymphohistiocytosis intestinal T‐cell lymphomas commonly used 7, 20 75–76 fluorochromes 2, 3 haemopoietic stem cell see also enteropathy‐ forward scatter (FSC) 24, 49, 122 associated T‐cell 1–2, 3–5 hairy cell leukaemia 68–69, lymphoma; monomorphic interpretation 8 93, 113 intestinal epitheliotropic limitations 8 minimal residual disease T‐cell lymphoma principles 2 (MRD) 78 intravascular large B‐cell problems and pitfalls 8 hairy cell leukaemia variant lymphoma 70 role 6–7 69, 91, 111 isatuximab 24 side scatter (SSC) 2, 3–5 hepatosplenic T‐cell fluorescent aerolysin lymphoma 74 k (FLAER) 41 HER2 see CD340 Ki‐67 42 paroxysmal nocturnal hereditary elliptocytosis, killer inhibitory receptor see haemoglobinuria case 119 CD158a‐k 78, 79, 122 hereditary spherocytosis, KIT see CD117 fluorochromes 1–3, 5–6, 7 case 106, 121 commonly used HHV8‐LANA1 41 l fluorochromes 2, 3 high‐grade B‐cell lymphoma Langerhans cell FMC7 41 with rearrangement of histiocytosis 65 follicular dendritic cells 12, MYC and BCL2, BCL6 or large granular lymphocytic 13, 17, 18, 19, 23, 24, 26, 35 both 70 leukaemia see T‐cell large follicular lymphoma 67–68, histiocytic sarcoma 66 granular lymphocytic 90, 111 HLA‐DR 41 leukaemia bindex.indd 130 01-09-2020 18:39:04 Index 131 LEF1 42 chronic lymphocytic characteristic light chain‐associated leukaemia (CLL) 67 immunophenotype of amyloidosis 72 diffuse large B‐cell mature T‐cell and NK‐cell lineage and stem cell lymphoma 70 neoplasms 73, 74 markers 49 follicular lymphoma chronic lymphoproliferative lintuzumab 22 67–68 disorder of NK cells 76 LL (lymphoblastic hairy cell leukaemia 68–69 extranodal NK/T‐cell lymphoma) 12 hairy cell leukaemia lymphoma, nasal type 76 LMP1 42 variant 69 hepatosplenic T‐cell loncastuximab 17 high‐grade B‐cell lymphoma lymphoma 74 lucatumumab 24 with rearrangement of intestinal T‐cell lymphomas lymphoblastic lymphoma MYC and BCL2, BCL6 or 75–76 (LL) 12 both 70 lymphomatoid
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