An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. ShigellaCyc: Shigella flexneri 2a str. 2457T Cellular Overview Connections between pathways are omitted for legibility. Author: Jonathan Wagg, SRI International a proteinogenic a proteinogenic amino acid a dipeptide GTP D-sorbitol a long-chain + a proteinogenic a proteinogenic a proteinogenic a proteinogenic a proteinogenic a proteinogenic a proteinogenic a proteinogenic a proteinogenic a proteinogenic (R)- formate sn-glycerol sn-glycerol sn-glycerol sn-glycerol H a proteinogenic amino acid a proteinogenic cob(I)alamin cob(I)alamin cob(I)alamin 2-oxoglutarate (S)-lactate D-xylose sulfate sulfate sulfate phosphate phosphate taurine taurine taurine L-carnitine amino acid amino acid amino acid a dipeptide a dipeptide a dipeptide amino acid amino acid amino acid amino acid amino acid amino acid amino acid fatty acid pantothenate L-fucose uracil D-xylose N-acetylneuraminate 3-phosphate maltose maltose maltose 3-phosphate 3-phosphate 3-phosphate D-gluconate D-gluconate D-gluconate D-galactopyranose D-galactopyranose melibiose amino acid amino acid predicted putative predicted transporter putative amino ATP-driven BtuC BtuD BtuE Ffh PanF KgtP FucP LldP FocA UraA XylE XylG NanT UgpB MalK MalG MalF UgpA UgpE GlpT GntP GntT GntU MglA GalP CysW CysA CysZ PitA PstB TauC TauA TauB complex of MelB CaiT AtpH LivG AroP YeaN BrnQ amino acid acid/amine DppA transporter DppB DppC LivM LivH YbaT YjdE YifK YeeF YcjJ LivJ FadL SORBITOL antiporter transport complex of protein a dipeptide + a long-chain (R)- formate uracil H cob(I)alamin cob(I)alamin cob(I)alamin GTP 2-oxoglutarate L-fucose (S)-lactate D-xylose D-xylose N-acetylneuraminate sn-glycerol maltose maltose maltose sn-glycerol sn-glycerol sn-glycerol D-gluconate D-gluconate D-gluconate D-galactopyranose D-galactopyranose sulfate sulfate sulfate taurine taurine taurine melibiose L-carnitine a proteinogenic a proteinogenic a proteinogenic a proteinogenic a dipeptide a dipeptide a dipeptide a proteinogenic a proteinogenic a proteinogenic a proteinogenic a proteinogenic a proteinogenic a proteinogenic a proteinogenic fatty acid pantothenate phosphate phosphate 3-phosphate 3-phosphate 3-phosphate 3-phosphate D-sorbitol amino acid amino acid amino acid amino acid a proteinogenic amino acid amino acid amino acid amino acid amino acid amino acid amino acid amino acid 6-phosphate amino acid a proteinogenic a dipeptide amino acid

an osmoregulated a phosphatidylglycerol periplasmic glucan Chemoautotrophic Carbohydrate Degradation Metabolic Regulator Polyprenyl Biosynthesis Energy Metabolism UDP-N-acetyl- undecaprenyl- [1-(2-amino-7-methyl- 4-(β-D- a linear malto- (S)-3- a (7Z,10Z,13Z a [protein]- a mismatched Biosynthesis α an alkylated DNA oxaloacetate a lipid II a [DsrC]-trisulfide RNA N-acetyl- acetyl-CoA nitrite superpathway of ubiquinol-8 Cofactor, Carrier, and Vitamin Biosynthesis Fermentation homolactic fermentation superpathway of glucose and xylose degradation -D-glucosamine diphospho-N- 4-oxo-7,8-dihydro- 4-(β-D-ribofuranosyl) ribofuranosyl) (7,8-dihydropterin- oligosaccharide a type IV prepilin hydroxybutanoyl- ,16Z,19Z)-3- L-histidine DNA base pair phosphoglycerol superpathway of menaquinol-8 biosynthesis I superpathway of tetrahydrofolate biosynthesis and salvage flavin biosynthesis I superpathway of superpathway of coenzyme A biosynthesis I (bacteria) superpathway of adenosylcobalamin salvage from cobinamide I NAD salvage pathway I (PNC VI cycle) hydrogen fucose degradation D-galactose degradation I (Leloir pathway) D-arabinose degradation I L-arabinose ITP L-citrulline biosynthesis (early decarboxylation) thiamine geranyl diphosphate acetylmuramoyl- 3H-pteridin-6-yl) aminobenzene- aminobenzene- 6-yl)methyl CoA oxodocosa- acetyl CoA methyl- nitrate transferase I: mdoB (bacteria and plants) demethylmenaquinol-8 biosynthesis I ppGpp metabolism degradation I 4-enzyme protein diphosphate biosynthesis oxidation D-glucopyranose L-alanyl-γ-D- ]ethyl diphosphate 5'-phosphate 5'-phosphate diphosphate 7,10,13,16,19- carboxylase, directed reductase 3-methyl-2- a 5,10- D-glucopyranose I (aerobic) β glycogen D-alanyl-D-alanine protein, 3- 3-oxoacyl- histidine IPP chorismate salvage I cob(II)inamide NAD + 6-phosphate -L-fucopyranose β-D-galactopyranose D-arabinopyranose glutamyl-L-lysyl- 3-methyl- sulfite tRNA pentaenoyl-[acp] biotin mismatch 1, delta GTP chorismate oxobutanoate methylenetetrahydrofolate L-arabinopyranose phosphorylase: carboxypeptidase, prepilin hydroxyacyl-CoA acetylornithine [acyl-carrier- kinase/ an osmoregulated GTP pppGpp H D-alanyl-D-alanine adenine DNA reductase, nucleotidyl carboxylase repair subunit: thiamine IPP glucokinase: 2 glucose-6- L-fucose phosphoenolpyruvate fraction A; peptidase deacetylase: protein] phosphatase a 1,2-diacyl-sn-glycerol isochorismate cob(I)alamin putative aldose-1- L-arabinose UDP-N- dihydropteroate dihydropteroate glgP glycosylase dehydrogenase; alpha transferase: periplasmic glucan with isopentenyl isochorismate thiamin 3-methyl-2-oxobutanoate geranyltranstransferase glk hydrogenase- phosphate isomerase: carboxykinase: pckA penicillin-binding dependent argE reductase: subunit: accC sensor protein: narJ hydroxymutase GTP adenolsyltransferase: epimerase: yihR isomerase: araA acetylglucosamine:N- synthase: S2703 synthase: S2703 maltodextrin II: alkA 3-hydroxybutyryl- subunit: cysI cca a (3R,7Z,10Z phosphoglycerol substituent diphosphate GTP hydroxymutase kinase: (p)ppGpp synthetase (farnesyldiphosphate 2 component: dehydrogenase: phosphoenolpyruvate for OmpR, mutH 2: menF cyclohydrolase hydroxymethyltransferase: btuR D-glucopyranose galactose-1- fucI L-ribulose acetylmuramyl- phosphorylase: protein 5: dacA protein CoA epimerase; ,13Z,16Z,19ZfabG)-3- acetyl CoA probable isomerase: cyclohydrolase 2: menF ycfN synthase): ispA hybD α 3-methyl- putative RNase panB II and guanosine-3,5- geranyl 6-phosphate zwf -L-fucopyranose (pentapeptide) carboxylase: ppc B: ppdB hydroxydocosa- carboxylase, modulates methyl- nitrate S3074 I: folE thiamine [corrinoid adenosyltranferase]- NMN epimerase D-ribulose malP adenine DNA delta(3)-cis- PH: rph isochorismate II: ribA bis pyrophosphate 3- [+ 6 isozymes] 6-phospho L-ribulokinase: pyrophosphoryl- [1-(2-amino-7-methyl- 7,8-dihydropterin- sulfite acetate L-citrulline car: accD expression directed reductase 7,8- 2,5-diamino-6- isochorismate phosphate asp cob(II)inamide diphosphate glucosephosphate L-fucose (mutarotase): galM a N- prepilin delta(2)-trans- 7,10,13,16,19- Ins(1,2,3,4,5,6)P pyrophosphohydrolase: A(H2) D-glucono- araB 4-oxo-7,8-dihydro- 6-ylmethyl-4-(β- glycosylase reductase: accA accB of ompF and 3: napA 6 DMAPP dihydroneopterin (5-phospho-D- isomerase: undecaprenol N- α D-ala acetylglucosamine- peptidase enoyl-CoA pentaenoyl-[acp] mismatch 2-oxoglutarate thiamin- 2-dehydropantoate spoT guanosine isomerase: pgi 1,5-lactone α -D- a linear malto- I: tag phosphoenolpyruvate yccK periplasmic 3'-triphosphate 2-oxoglutarate aspartate 1- -D-galactopyranose acetylglucosamine 3H-pteridin-6-yl)]ethyl- D-ribofuranosyl) -N-acetylmuramyl- dependent isomerase; a nucleoside malonyl-CoA ompC: envZ repair nitrate decarboxylase; ribosylamino) monophosphate pentaphosphatase, fucI L-ribulose 5-phosphate β glucopyranose oligosaccharide IDP RNA a [protein]- glucose-1- geranyltranstransferase decarboxylase; decarboxylase: (p)ppGpp F6P 6-phosphogluconolactonase: transferase: murG 4-( -D-ribofuranosyl) aminobenzene (tetrapeptide) protein enoyl-CoA diphosphate protein: SHCHC pyrimidin- kinase: thiL ketopantoate exopolyphosphatase: D-ribulose ditrans,octacis- UDP 1-phosphate a DNA containing N-phospho- phosphatase: (farnesyldiphosphate SHCHC panD synthetase I (GTP ybhE L-fuculose putative putative aminobenzene 5'-phosphate an alkylated pyrophosphoryl- C: ppdC hydratase: fadB a [DsrC mutS 4(3H)-one reductase: apbA [corrinoid adenosyltranferase]- nicotinamide gppA 1-phosphate undecaprenyldiphospho- sulfite L-histidine a properly agp synthase: menD synthase: menD thiamine pyrophosphokinase): relA 6-phosphofructokinase galactokinase: wcaK 5'-phosphate nucleobase an apurinic/ protein]-dithiol D-myo-inositol synthase): ispA 7,8- bifunctional cob(I)inamide D-gluconate epimerase/ N-acetyl-(N-acetyl-β-D- undecaprenol matched 2-succinyl-5- diphosphate β-alanine II: pfkB Other galactokinase: galK apyrimidinic site acetoacetyl-CoA (1,2,4,5,6)- geranyl dihydroneopterin pyrimidine 2-succinyl-5- (R)-pantoate cob(I)alamin glutathionylspermidine 6-phosphate aldolase: sgaE glucosaminyl)muramoyl- enolpyruvoyl- an N-terminal DNA base pair pentakisphosphate diphosphate 3'-phosphate deaminase/ enolpyruvoyl- adenolsyltransferase: synthetase/amidase: gsp 6-phosphofructokinase gluconate-6- L-ribulose-5- L-alanyl-γ-D-glutamyl-L- 6-hydroxy-3- GTP ppGpp α α L-phenylalanyl- a peptide 6-hydroxy-3- btuR I: pfkA malate/L-aspartate L-fuculose -D-galactose 1-phosphate UDP- -D-glucose phosphate 4- geranyltranstransferase cyclohexene- reductase: acyl carrier protein metabolism pantothenate [+ 5 isozymes] phosphate lysyl-D-alanyl-D-alanine [type IV prepilin] cyclohexene- β-D-fructose 1,6- shuttle pathway 1-phosphate DHAP glycolaldehyde epimerase: araD (farnesyldiphosphate 1-carboxylate ribD synthetase: dehydrogenase: 5-amino-6-(5- 1-carboxylate adenosylcobinamide nicotinate bisphosphate gnd a protein synthase): ispA (1R,6R)-2- a holo acyl- panC (p)ppGpp synthetase aldehyde D-erythro-7,8- phospho-D- (1R,6R)-2- L-fuculose-1- D-xylulose 5-phosphate an oxidized a long-chain a long-linear a cis,cis- (4R)-4-hydroxy- (S)-3- a [protein] a secondary succinyl-6- carrier protein II and guanosine-3,5- asp D-ribulose a peptidoglycan + a cis,cis-delta7,19- + an L-asparaginyl- a β-lactam nitrate succinyl-6- nicotinate nucleoside dehydrogenase: H NAD FMN NAD(P)H H α hydroxybutanoyl- citrate Asn (2E,6E)-farnesyl dihydroneopterin ribosylamino)uracil phosphate 2 ferredoxin [iron- a malonyl-[acp] fatty acyl-[acyl- a malonyl-[acp] -D-glucan delta15,27- a malonyl-[acp] 2-oxoglutarate C-terminal glu alcohol an arachidoyl-[acp] Asn tRNA asp putative serine hydroxy-2,4- diphosphate kinase: ndk bis pyrophosphate 3- putative aspartate 5-phosphate C38:2-[acp] [tRNA ] diphosphate chorismate hydroxy-2,4- 5,6-dimethylbenzimidazole phosphoribosyltransferase: aldolase: aldH sulfur] cluster carrier protein] C46:2-[acp] CoA L-glutamate alcohol beta- probable protease: S1990 cyclohexadiene- bifunctional (R)-pantothenate epimerase/ aminotransferase: enoyl-[acyl- chorismate cyclohexadiene- pncB pyrophosphohydrolase: fucA [+ 3 isozymes] 4-enzyme dehydrogenase: lactamase: [+ 2 isozymes] octaprenyl pyrimidine adenosyl-cobinamide aldolase: sgaE N-acetylmuramoyl- glycogen carrier- nitrate 1-carboxylate D-ribulose 1-carboxylate CoA:apo-[acyl-carrier-protein] acyl carrier protein nicotinate-nucleotide spoT (p)ppGpp synthetase aspC D-ribulose-5- ribosephosphate sulfite reductase, 2-keto-3- protein, 3- citrate lyase: aminodeoxychorismate deaminase/ pantothenate putative 3-oxoacyl- 3-oxoacyl- 3-oxoacyl- adhP peptidyl- ampC reductase diphosphate chorismate synthase: yfbB 6-(hydroxymethyl) 5-phosphate pantetheinephosphotransferase: phosphodiesterase: phosphate NaMN II and guanosine-3,5- [+ 3 isozymes] oxaloacetate phosphate 3- isomerase: rpiA glycolate l-alanine alpha subunit: cysI phosphorylase: deoxygluconate hydroxyacyl-CoA citE citD citF ribosomal protein] aspartate a peptide (1R,6R)-6-hydroxy- synthase: pabA pabB synthase: yfbB kinase: coaA dimethylbenzimidazole- (p)ppGpp hydrogenase putative 3: napA synthase: ispB reductase: (1R,6R)-6-hydroxy- DHAP (S)-lactaldehyde D-arabinose amidase I: amiA [acyl-carrier- [acyl-carrier- glgP [acyl- 6-phosphate protein S6 reductase tRNA tRNA beta- lyase: ubiC -7,8-dihydropterin 3,4 acpS acpD P phophoribosyl synthetase I (GTP bis pyrophosphate 3- putative epimerase: subunit: S3245 ferrisiderophore dehydrogenase; citrate lyase beta all-trans- 2-succinylcyclohexa- 4-amino-4- ribD 2-succinylcyclohexa- (R)-4'- nicotinate- D-xylose D-ribose 5- degradation II protein] protein] carrier- modification aldehyde (NADH) hydrolase: synthetase: lactamase nitrate 7, 8-dihydro-6- dihydroxy-2- transferase: cobT pyrophosphokinase): relA pyrophosphohydrolase: triosephosphate rpe N-acetylmuramoyl- reductase, maltodextrin aldolase 3-hydroxybutyryl- chain (acyl lyase octaprenyl 2,4-diene-1- 5-amino-6-(5- enzyme: S0868 phosphate L-sorbose putative synthase reductase: protein] protein: rimK reductase: : fabI pth aspS induction reductase 4-hydroxybenzoate deoxychorismate butanone-4- 2,4-diene-1- phosphopantothenate mononucleotide spoT l-alanine amidase phosphorylase: and 2-keto-4- CoA epimerase; subunit): citE diphosphate carboxylate hydroxymethylpterin- phospho-D- isomerase: tpiAD-glyceraldehyde [+ 39 isozymes] degradation D-arabinopyranose hydrogenase I: fabB fabG flavin reductase synthase S1557 a (2E)-icos- signal 1, delta 4-amino-4- phosphate carboxylate α-ribazole 5'-phosphate adenylyltransferase: DHAP D-xylulose II, murein malP hydroxyglutarate delta(3)-cis- O-succinylbenzoyl- pyrophosphokinase: ribitylamino)uracil an apo acyl- phosphopantothenoylcysteine adenosylcobinamide-GDP 3-phosphate L-fucose subunit: ygbO (NADPH:flavin 2-enoyl-[acp] subunit: deoxychorismate O-succinylbenzoyl- ybeN GDP 5-phosphate keto-L-sorbose hydrolase: amiB I: fabB aldolase: eda delta(2)-trans- a [protein] C- a ketone transducer 4-hydroxybenzoate- folK synthase: carrier protein synthetase: dfp (S)-malate isomerase: oxidoreductase) an L-aspartyl- CoA synthase: lyase: pabC CoA synthase: glyceraldehyde- 1-phosphate α asn tRNA Asn AmpG: narJ ribB nicotinate adenine D-xylulose α-D- enoyl-CoA acetate oxaloacetate terminal -L- Asn octaprenyltransferase: menC (7,8-dihydropterin- (R)-4'- putative L- fucI a reduced a cis,cis-delta9,21- a long-chain 3- : ubiB a long-linear [tRNA ] ampG menC cobalamin 5- 3-phosphate galactose-1- + α nitrite 6-yl)methyl 1-deoxy-L- phosphopantothenoyl- dinucleotide transketolase sorbose-1-P- ditrans,octacis- NADH H glucopyranose α-D-glucan a cis,cis- isomerase; glutamate- - ubiA 4-aminobenzoate phosphate dehydrogenase xylulokinase: phosphate UDP-galactose-4- D-ribulose a peptidoglycan ferredoxin [iron- 3-oxo-C40:2-[acp] oxoacyl-[acp] a substituted 2-succinylbenzoate diphosphate glycero-tetrulose NAD 1 isozyme: tktA reductase: undecaprenyldiphospho- 1-phosphate delta17,29-3- glyoxylate pyruvate enoyl-CoA L-glutamate ARP 2-succinylbenzoate L-cysteine A: gapA xylB pentapeptide sulfur] cluster β-amino acid synthase: cobS γ-glutamyl cycle uridylyltransferase: epimerase: galE + oxo-C48:2-[acp] hydratase: fadB 4-hydroxy-3- 4-phosphate synthetase: transketolase sorE N-acetyl-(N- FMNH NAD(P) 4'-phosphopantothenoylcysteine Cell Structure Biosynthesis D-xylulose galT D-sorbitol 2 octaprenylbenzoate O-succinylbenzoate- 7,8- O-succinylbenzoate- nadE 2 isozyme: tktB acetylglucosaminyl)muramate crotonyl-CoA superpathway of thiamine diphosphate biosynthesis I decarboxylase: dfp 13-DPG 5-phosphate α-D-glucopyranose 1-phosphate UDP-α-D-galactose 6-phosphate CoA ligase: menE dihydropteroate lumazine CoA ligase: menE adenosylcobalamin glutathione D-ribulose 3-octaprenyl-4- NAD + 4-(2'- synthase: folP synthase: 5'-phosphate peptidoglycan biosynthesis III (mycobacteria) D-sedoheptulose D-glyceraldehyde glucitol (sorbitol) hydroxybenzoate 4-(2'- 4'-phosphopantetheine peptidoglycan biosynthesis I (meso-diaminopimelate containing) phosphoglycerate 5-phosphate carboxyphenyl)- ribH 7-phosphate 3-phosphate -6-phosphate α carboxy-lyase: ubiX dihydropteroate carboxyphenyl)- cys kinase: pgk putative an inactive a protein with a [disulfide- a [prolipoprotein]- a cis,cis- a long-chain GDP- -D- a protein nitrate NarK nitrate UDP-N-acetyl- dehydrogenase: a reduced a cis,cis-delta9,21- + + a cis,cis-delta19- 4-oxobutyryl-CoA synthase: S2703 pantetheine- UDP-N-acetyl- phosphoglucomutase: ribonucleoside bond carrier a malonyl-[acp] S-1,2-diacyl-sn- NADP FMNH a purine delta13,25- a malonyl-[acp] a purine 2'- H NADP a cytidine 34 Ap4A mannose with incorrect nitrate 4-oxobutyryl-CoA α-D-glucosamine SAM reduced L- 2 2 fatty acid lys trp 2-octaprenylphenol dihydroxynaphtoic 6,7-dimethyl-8-(1- phosphate α-D-glucosamine transaldolase mrsA srlD flavodoxin C40:2-[acp] ribonucleoside deoxyribonucleoside Ile2 37-C56:2-[acp] a 5,10- dihydroxynaphtoic L-cysteine:[protein superpathway of pyridoxal 5'-phosphate biosynthesis and salvage glutathione gamma- 3-phospho-D-glycerate L-rhamnose degradation I triphosphate cysteine residues protein] carrying glyceryl-L-cysteine C44:2-[acp] 2-acyl- in tRNA diadenosine enoyl-[acyl- disulfide bondsprotein nitrate acid synthetase: D-ribityl)lumazine adenylyltransferase: UDP-N-glucosamine 1- A: talA putative sorbitol- 7,8- methenyltetrahydrofolate acid synthetase: cysteine] adenosylcobalamin synthetase: glutamyltranspeptidase: ggt UDP-N-glucosamine 1- phosphoglucomutase: reductase a disulfide bond glycerophospho- tetraphosphatase: disulfide reductase (2E,6E)-farnesyl riboflavin kdtB carboxyvinyltransferase: melibiose degradation putative carrier- GDP- H O AqpZ H O 2-octaprenylphenol menB dihydropteroate (2E,6E)-farnesyl menB sulfurtransferase: D-erythrose gshB carboxyvinyltransferase: phosphoglyceromutase [+ 2 isozymes] pgm α 6-phosphate 2- ferrisiderophore ethanolamine 1, delta 2 2 5,10-methylene- murA phosphoglyceromutase -L-rhamnopyranose 3-oxoacyl- prolipoprotein 3-oxoacyl- hydrogenase cell cycle apaH tryptophanase: protein] mannose isomerase hydroxylase: yigR diphosphate 1,4-dihydroxy-2- dihydrofolate:folylpolyglutamate synthase: diphosphate yfhO 3'-dephospho- 4-phosphate murA 1: gpmA dehydrogenase: thiol:disulfide reductase, purine-nucleoside purine-nucleoside acyltransferase; subunit: tetrahydrofolate 1,4-dihydroxy-2- UDP-N-acetyl-α- 1: gpmA D-erythrose glycogen degradation I anaerobic [acyl-carrier- signal [acyl- subunit: S3245 protein: diadenosine tnaA reductase mannosyl II: dsbC 3-(all-trans octaprenyl naphthoyl-CoA synthetase; dihydrofolate ribH ribE an [L-cysteine CoA UDP-N-acetyl-α- phosphoglyceromutase D-glucopyranose 6-phosphate sorD melibiose interchange flavin reductase phosphorylase: phosphorylase: acyl-acyl- narJ dehydrogenase; octaprenyl naphthoyl-CoA a [ThiS sulfur- D-erythrose D-glucosamine- [+ 2 isozymes] F6P ribonucleotide protein] peptidase carrier- mesJ tetraphosphatase: (NADH) hydrolase: -octaprenyl) diphosphate synthetase: folC desulfurase]-S- dephospho- 4-phosphate keto-D-fructose protein: dsbD (NADPH:flavin deoD deoD putative carrier protein protein a reduced riboflavin diphosphate carrier protein] 4-phosphate D-glucosamine- 2: gpmB reductase synthase (SPase II): lspA protein] aphA : fabI wcaH probable benzene-1,2-diol 5,10-methylene- sulfanyl-L-cysteine enolpyruvate a glycogen oxidoreductase) hydrogenase hypothetical a trans-delta2- disulfide H O putative c-type synthase: ispB 7,8-dihydrofolate synthase: ispB CoA dehydrogenase: enolpyruvate transketolase 6-phosphate alpha-galactosidase: melA activating [+ 2 isozymes] I: fabB synthase synthetase: aas nitrate 2 3-demethylubiquinone- all-trans- tetrahydrofolate UDP-N- 2-phospho-D-glycerate β-L-rhamnopyranose : ubiB subunit: ygbO a long-chain protein: yacA ADP indole pyruvate cis,cis-delta19,37- isomerase cytochrome cytochrome monoglutamate riboflavin all-trans- kinase: yacE epd UDP-N- 1 isozyme: tktA maltodextrin protein: nrdG α-D-ribose- I: fabB 2-deoxy-α- reductase an oxidized octaprenyl 1,4-dihydroxy- cyclohydrolase: acetylenolpyruvoylglucosamine a [disulfide-bond an (S-diacyl- a lipoprotein fatty acyl-[acyl- C56:3-[acp] a proteinI: dsbA 9 3-methyltransferase kinase / FAD octaprenyl 1,4-dihydroxy- acetylenolpyruvoylglucosamine phosphorylase: a protein with sulfite reductase, D-ribose 1- D-mannose O oxidase c-type folD 4-phospho- transketolase L-rhamnose sn-glyceryl) 1-phosphate GDP 3: napA 2 and 2-octaprenyl- diphosphate 2-naphthoate coenzyme A reductase: murB D-galactosamine and N- D-galactopyranose D-glucopyranose carrier protein] signal peptide a purine base a purine base carrier protein] 34 with correct a reduced synthetase: diphosphate 2-naphthoate a [ThiI sulfur- a carboxy- reductase: murB enolase: eno 2 isozyme: tktB malP isomerase: a disulfide bond a cis,cis-delta11,23- alpha subunit: cysI phosphate a lysidine cytochrome 10 D-erythronate an active with reduced L- -L-cysteinyl- + nitrite 6-hydroxy phenol an N - D-glyceraldehyde an α-(γ-L- ala UDP-N-acetyl- acetyl-D-galactosamine a cis,cis- NADPH H in tRNA Ile2 disulfide bonds H O c-type ribF γ ala UDP-N-acetyl- rhaA a flavodoxin 3-oxo-C42:2-[acp] 2 carrier protein]- adenylated- erythronate- -L-glutamyl- α D-glyceraldehyde glycogen 5'-deoxyadenosine met ribonucleoside cysteine residues [apolipoprotein] delta15,27-3- methylase: ubiG 1,4-dihydroxy- formyltetrahydrofolate 1,4-dihydroxy- 3-phosphate glutamyl)-L- -D-muramate α-D-muramate degradation semiquinone YgbE cytochrome 2-methoxy- a 7,8-dihydrofolate S-sulfanyl- [ThiS sulfur- 4-phosphate L-cysteine cys gly phosphoenolpyruvate 3-phosphate phosphorylase: N-acetyl-D- triphosphate an oxidized 2-naphthoate FMN amino acid keto-L-rhamnulose FMN NADPH H + oxo-C46:2-[acp] 2-naphthoate 1-deoxyxylulose- L-cysteine carrier protein] glgP O c-type 6-(all-trans- octaprenyltransferase: phosphoribosylglycinamide tyr dehyrogenase: L-alanine galactosamine reductase 2 octaprenyltransferase: L-alanine pyruvate glyceraldehyde- acytochrome reduced octaprenyl)phenol riboflavin 5-phosphate pdxB adding enzyme, glu 6-phosphate fructose menA dihydrofolate formyltransferase 2: purT menA aminopeptidase adding enzyme, glu 3-phosphate an α-limit dextrin H O c-type 2-octaprenyl-6- kinase / FAD synthase; UDP-N-acetyl- kinase II: pykA N-acetylglucosamine- degradation 2 reductase phosphoribosylglycinamide (3R)-3-hydroxy-2-oxo- N: pepN UDP-N-acetyl- dehydrogenase a 2'- a cis,cis- a peptidyl- a peptide with a cis,cis- a cis,cis- cytochrome flavoprotein: dxs pyruvate an N-modified + YfeH an oxidized methoxyphenol 4- synthetase: 4 phosphooxybutanoate muramate:alanine glutamate A: gapA 6-phosphate β-D-fructofuranose an acyl-[acyl- a cis,cis-delta5,23- maltohexaose H NAD O-phospho- an acyl-CoA H O a decanoyl-[acyl- nitrate demethylmenaquinol-8 type I: folA formyltransferase 1: purN a thiocarboxylated- muramate:alanine glutamate a malonyl-[acp] deoxyribonucleoside delta15,33- a malonyl-[acp] dipeptidase 2 cys an N-terminal 2 delta17,35-3- delta17,29- asp monoxygenase: ribF demethylmenaquinol-8 1-deoxy-D- ligase: murC racemase: kinase I: pykF deacetylase: agaA L-rhamnulofuranose 1-phosphate a 1-lysophosphatidylethanolamine carrier protein] dGTP C42:2-[acp] [DNA] aminoacyl-[tRNA] L-homoserine carrier protein] DHAP O c-type 3-phosphoserine gamma- ligase: murC racemase: 5'-triphosphate C52:2-[acp] Dcp substrate L-alanine hydroxyC54:2- C48:2-[acp] probable 2 xylulose 5- [ThiS sulfur- fructose-1- enoyl-[acyl- enoyl-[acyl- 2+ 2+ ubiH 2-iminoacetate glutamate- L-cysteinylglycine murI 13-DPG N-acetylglucosamine- Zn ZntA Zncytochrome ubiquinone/ FAD phosphate carrier protein] aminotransferase: murI pyruvate rhamnulokinase: phosphate [acp] 3-oxoacyl- carrier- carrier- nitrate 2-methoxy-6-all a tetrahydrofolate cysteine UDP-N-acetyl- a debranched 6-phosphate maltodextrin putative acyl-CoA menaquinone serC UDP-N-acetyl- maltotetraose rhaB kinase: fruK 3-oxoacyl- putative peptidyl- dipeptidyl cystathionine [acyl-carrier- quinolinate reductase trans-octaprenyl- α-D-muramoyl- D-glt α-limit dextrin β-D-fructose 1,6- 2-acyl- phosphorylase: 3-oxoacyl- hydrogenase peptidase thioesterase protein] protein] biosynthesis ligase: gshA α-D-muramoyl- D-glt L-lactate phosphoglycerate deacetylase: nagA deoxyguanosine carboxypeptidase gamma- protein] 3: napA 1,4-benzoquinol thiamin D-glyceraldehyde 4-phosphooxy- L-alanine L-rhamnulose glycerophospho- [acyl-carrier- polymerase/ malP tRNA [acyl- E: pepE II: tesB reductase reductase synthetase, methyltransferase: folate transformations I pyruvate L-alanine dehydrogenase: kinase: pgk D-galactosamine bisphosphate triphosphate subunit: S3245 glycine glycine ubiquinone/ biosynthesis 3-phosphate L-threonine maltodextrin 1-phosphate ethanolamine protein] proteinase: glycogen hydrolase: carrier- II: dcp synthase: metB aminopeptidase reductase: (NADH) (NADH) A protein: nitrate ProV ubiE lldD 6-phosphate glucose and glucose-1-phosphate degradation triphosphohydrolase: dgt putative betaine betaine menaquinone protein, NAD de novo biosynthesis pyridoxal UDP-N- 3-phospho- acyltransferase; synthase yajG pth protein] N: pepN a cis,cis-fabG : fabI : fabI nadA reductase a 5,10- AIR folate transformations III (E. coli) UDP-N- phosphorylase: phosphorylase: hydrogenase a trans-delta2- biosynthesis thiazole I (from aspartate) 1-deoxyxylulose- phosphate acetylmuramoylalanine- (S)-lactate D-glycerate rhamnulose- α acyl-acyl- I: fabB [+ 11 isozymes] synthase a carboxylate delta17,35-3- a (2E)-dec- 1, delta menaquinol-8 methylenetetrahydrofolate acetylmuramoylalanine- mixed acid fermentation malP -D- glgP subunit: ygbO cis,cis-delta17,29- methyltransferase: thiamine moiety: thiH 5-phosphate biosynthetic D-glutamate ligase: murD phosphoglyceromutase phosphate glucopyranose carrier protein I: fabB a dipeptide a peptide L-cystathionine oxo-C54:2-[acp] 2-enoyl-[acp] subunit: 5,10-methylene- D-glutamate ligase: murD glycogen an N-modified an uncharged C48:3-[acp] an acid XasA an acid ubiE biosynthesis synthase; protein a tetrahydrofolate 1: gpmA aldolase: rhaD 1-phosphate synthetase: aas triphosphate quinolinate narJ thiamin asp pyridoxine glu 5-oxo-L-proline phosphorylase: D-tagatofuranose 2'-deoxyguanosine α-D- tRNA ala a peptide 6-methoxy-3- adenosylcobalamin tetrahydrofolate protein, flavoprotein: dxs PdxA: pdxA UDP-N-acetyl- phosphoenolpyruvate a cis,cis-delta7,25- [DNA] maltopentaose amino acid biosynthesis meso- UDP-N-acetyl- [+ 2 isozymes] glgP 6-phosphate glucopyranose a cis,cis- NADH H + nitrite methyl-2-all- salvage from cobalamin reductase: metF L-aspartate D-ala α-D-muramoyl-L- meso- 3-oxo-C44:2-[acp] pyrimidine protein, 3-amino-1- pyridoxamine diaminopimelate D-ala α-D-muramoyl-L- 2-phospho- DHAP (S)-lactaldehyde periplasmic 1-phosphate delta17,35-3- trans-octaprenyl- oxidase: frdA 1-deoxy-D-xylulose B12-dependent alanyl-D-glutamate diaminopimelate putative a 5-methyltetrahydrofolate moiety: thiC thiazole hydroxyacetone pyridoxal/ alanyl-D-glutamate phosphoenolpyruvate pyruvate kinase II: pykA D-glycerate glucose-1- putative a phosphatidylethanolamine oxo-C54:2-[acp] Ni 2+ NikB Ni 2+ 1,4-benzoquinol lipoate cob(I)alamin a 5,10- 2-iminosuccinate 5-phosphate homocysteine-N5- D-alanine- tagatose 6- moiety: thiG 1-phosphate pyridoxine/ pyridoxal D-alanine- carboxylase: ppc pyruvate kinase I: pykF α-D- phosphatase: phosphoglucomutase: biosynthesis and methylenetetrahydrofolate HMP-P methyltetrahydrofolate D-alanine meso- enolase: maltotriose phosphate quinolinate pyridoxamine kinase 2 / D-alanine meso- glucopyranose agp mrsA incorporation I B12-dependent transmethylase: metH ligase diaminopimelate- eno kinase 2: agaZ 2-[(2R,5Z)- synthetase, A putative kinase: pdxK pyridoxine ligase diaminopimelate- 1-phosphate maltodextrin phosphoglucomutase: a methylated an N-terminal a plant soluble a cis,cis- S-(4-hydroxy- an (L- a peptide with a cis,cis- a cis,cis- homocysteine-N5- phosphomethylpyrimidine A: ddlA adding oxaloacetate pyruvate dethiobiotin a sulfurated a cis,cis-delta5,17- an L-leucyl- a ribonucleoside a nucleoside a cis,cis-delta5,17- L-arabinitol Ni 2+ NikC Ni 2+ an octanoyl-[acp] cob(II)alamin 5,10-methylene- 2-carboxy-4- protein: nadA pyridoxal kinase: pdxY adding phosphoenol putative SAM 2-oxoglutarate nucleobase a malonyl-[acp] heteroglycan formate delta17,29- a malonyl-[acp] nonenal-3-yl)-L- RNA cysteinylglycine) an N-terminal delta19,37- delta19,31- a hexanoyl-[acp] a protein methyltetrahydrofolate kinase: thiD pyridoxal dihydrofolate enzyme: murE A: ddlA glucosidase: D-glucopyranose glucokinase: pgm [sulfur carrier] C36:2-[acp] L-lysyl-[protein] [tRNA Leu ] triphosphate triphosphate C36:2-[acp] 3-demethylubiquinol-8 lipoate tetrahydrofolate methylthiazol-5(2H phosphate pyridoxal D-alanine- enzyme: murE pyruvate tagatose 6- within DNA C48:2-[acp] cysteinylglycine -S-conjugate L-methionine 3-hydroxy- C50:2-[acp] putative serine transmethylase: metH kinase 2 / pyridoxal/ reductase type I: folA malZ glk enoyl-[acyl- enoyl-[acyl- enoyl-[acyl- carboxy- dehydrogenase; quinolinate D-alanine- putative phosphate glucose aldose biosynthesis hydroxymethyltransferase: glyA HMP-PP )-ylidene]ethyl biosynthetic pyridoxine pyridoxine/ D-alanine UDP-N-acetyl- putative enzyme: S0868 fermentative D-lactate pyruvate carrier- C56:2-[acp]3-oxoacyl- 3-demethylubiquinone- serine D-alanine putative pyruvate kinase 1: gatZ glycogen carrier- carrier- terminal protein 5,10-methylene- phosphate protein: pdxJ pyridoxamine a 7,8-dihydrofolate a 5-methyltetrahydrofolate ligase α UDP-N-acetyl- [+ 39 isozymes] dehydrogenase: ldhA kinase phosphoglucomutase: maltose dehydrogenase: D-glucopyranose biotin alkylated leucyl, anaerobic RNA methionine [acyl-carrier- reductase: 9 3-methyltransferase glycine quinolinate kinase: pdxY pyridoxal -D-muramoyl- ligase α formate-lyase 2 3-oxoacyl- phosphorylase: 3-oxoacyl- aminopeptidase aminopeptidase protein] protein] protein] protease predicted a [lipoyl-carrierLipB: lipB cob(II)alamin- tetrahydrofolate kinase: pdxK hydroxymethyltransferase: glyA glycine decarboxylase, B: ddlB -D-muramoyl- II: pykA mrsA D-tagatofuranose gcd synthesis, DNA phenylalanyl- ribonucleoside- polymerase, protein] yafB and 2-octaprenyl- decarboxylase, phosphoribosyltransferase: kinase 2 / L-alanyl-γ-D- B: ddlB activating enzyme: ybiY 6-phosphate [acyl-carrier- glgP [acyl- aminopeptidase: reductase reductase reductase for ATP-driven protein] N 6 - [corrinoid cyclohydrolase: P protein of glycine L-alanyl-γ-D- 1,6-bisphosphate sulfur N: pepN N: pepN phosphoglucomutase: repair protein] tRNA-protein triphosphate carrier- alpha map reductase: putative Ni 2+ transporter Ni 2+ 6-hydroxy phenol P protein of nadC pyridoxamine pyridoxine D-alanyl-D-alanine glutamyl-meso-2,6- (S)-malate [+ 5 isozymes] (R)-lactate pyruvate D-glucono- maltodextrin (NADH): fabI (NADH) (NADH) penicillin- octanoyl-L-lysine adenosyltranferase] folD pyridoxine 5'-phosphate thymidylate cleavage system: gcvP D-alanyl-D-alanine glutamyl-meso-2,6- pgm insertion?: protein: transferase: reductase: nrdD subunit: rpoA a trans-delta2-cis,cis a cis,cis-fabG aldehyde methylase: ubiG glycine cleavage 5'-phosphate kinase: pdxY diaminopimelate kinase 1,5-lactone synthase phosphorylase: protein] a trans-delta2-: fabI : fabI binding complex lipoate NaMN synthetase: thyA lipoamide diaminopimelate tagatose- bioB alkB aat -5,17-C36:3-[acp] delta19,37-3- reductase: system: gcvP thiamine 5,10-methylene- fumarase C, fumarate I: pykF D-glucopyranose I: fabB malP synthase S-(4-hydroxy- [+ 3 isozymes] a (2E)-hex- protein of Ni2+ ubiquinone/ synthesis pyridoxal/ bisphosphate an L-cysteine- cis,cis-delta19,31- S1557 phosphate dehydrogenase tetrahydrofolate D- hydratase Class acetyl-CoA formate trehalose degradation II (cytosolic) a 2'- I: fabB nonenal-3- gly gly met a peptide oxo-C56:2-[acp] 2-enoyl-[acp] 3: prc protein lipoamide nicotinate- pyridoxine pyridoxine pyridoxine/ a (6S)-5-formyltetrahydrofolate D- a [protein] S-conjugate C50:3-[acp] aldehydo-L- Na + ChaA Na + menaquinone cob(I)alamin- a tetrahydrofolate a 5,10- a (6S)-5- (NADH): lpdA alanine:D- II; isozyme: fumC pyruvate aldolase 1: gatY a nucleobase deoxyribonucleoside yl)-L-cysteine dehydrogenase thiamin- dehydrogenase; biotin 5'-deoxyadenosine an unsulfurated formaldehyde succinate Leu α biosynthesis LipA: lipA [corrinoid methenyltetrahydrofolate formyltetrahydrofolate mononucleotide phosphate phosphate pyridoxamine 5,10-methylene- alanine:D- glucokinase: met a cis,cis-delta7,19- N-terminal L- a tRNA -D- a plant soluble RNA arabinose a peptide 5,10-methylene- 5,10-methylene- alanine- [+ 2 isozymes] D-gluconate α,α-trehalose [sulfur carrier] within DNA 5'-triphosphate methyltransferase: a [lipoyl-carrier (NADH): lpdA monophosphate adenylyltransferase: oxidase: pdxH oxidase: pdxH kinase: pdxK tetrahydrofolate alanine- citrate synthase: gltA phosphotransacetylase: pta aldehyde formate hydrogenlyase glk D-glyceraldehyde leucyl-L-lysine glucopyranose heteroglycan a cis,cis- 6 adenosyltranferase] adding DHAP 3-oxo-C38:2-[acp] protein]-N -[(R) tetrahydrofolate kinase: thiL ybeN tetrahydrofolate adding Kdo transfer to complex: hycB hycF hycE L-lactate fermentative 3-phosphate 1-phosphate delta19,31-3- ubiE cob(I)alamin reductase: metF fumarate dehydrogenase: aldA + + -dihydrolipoyl]- dehydrogenase; thiamine diphosphate salvage II cyclohydrolase: folD enzyme: lipid IV I (E. coli) dehydrogenase: D-lactate Na NhaB Na adenolsyltransferase: thiamine nicotinate adenine enzyme: A [+ 4 isozymes] cytoplasmic trehalase: treF oxo-C50:2-[acp] 5,10-methylene- PLP a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate murF citrate lldD dehydrogenase: ubiquinol-8 L-lysine btuR diphosphate dinucleotide murF fumarate reductase, acetyl phosphate trehalase: treA tetrahydrofolate S-adenosyl-L-methionine salvage I CMP-Kdo lipid IV (E. coli) CO H adenosylcob(III) 5-(2-hydroxyethyl)-4-methylthiazole A anaerobic: frdD 2 2 ldhA sucrose degradation I formyltetrahydrofolate NAD NAD 4-amino-2-methyl-5- 5,10-methylene- UDP-N-acetyl- aconitate hydrase B: acnB acetaldehyde a [DNA]-3'- a 5'-phospho- DNA with adenine:7,8- a cis,cis- (6R)-L-erythro-6,7- (4S)-4-hydroxy-2- methyl β-D-glucoside a cis,cis- a cis,cis- d-biotin d alamin-[corrinoid cyclohydrolase: UDP-N-acetyl- frdC frdB frdA putative kinase: tdcD (sucrose phosphotransferase) NAD + a cis,cis-delta3,21- ammonium NAD(P) + H O a maltodextrin a ribonucleoside a cis,cis-delta9,21- a (7Z)-tetradec- D-mannitol + + citrate lyase deformylase: purU synthetase: synthetase: pyrimidinemethanol biotin biosynthesis from tetrahydrofolate (S)-lactate trehalose degradation VI (periplasmic) α SAM a malonyl-[acp] 2 dihydro-8- delta17,35- a malonyl-[acp] delta11,23-3- delta21,39- Na NhaA Na folD α-D-muramoyl- α aconitate hydrase 1: acnA β-D-glucopyranose -D-glucopyranose GTP hydroxyl [DNA] dihydrobiopterin oxoheptanedioate diphosphate 6-phosphate -sulfoxide adenosyltranferase] 4-methyl-5(b- -D-muramoyl- 3-deoxy-D-manno- D-glucopyranose G C40:2-[acp] C40:2-[acp] 7-enoyl-[acp] activation nadE nadE pyridoxal/pyridoxine/ 8-amino-7-oxononanoate I dehydrogenase; γ acetate kinase: ackA alcohol (R)-lactate sucrose 6 oxoguanine mismatch C54:2-[acp] dihydropteridine ribonucleoside hydroxyC42:2- C58:2-[acp] putative biotin SAM hydroxyethyl) L-alanyl- -D- L-alanyl-γ-D- octulosonic-acid succinate 6-phosphate enoyl-[acyl- enoyl-[acyl- enoyl-[acyl- tetrahydromonapterin pyridoxamine 5,10-methylene- cis-aconitate dehydrogenase: adhP α α -phosphate reductase: hmpA [acp] 3-oxoacyl- aldose sulfoxide guanylyl molybdenum glutathione-glutaredoxin + glutamyl-meso-2,6- trehalose degradation , -trehalose glycogen diphosphate carrier- carrier- carrier- thioredoxin 3'-dephospho- biosynthesis NAD -thiazole (8S)-8-amino-7-oxononanoate folate polyglutamylation glutamyl-meso-2,6- transferase (KDO acetate DNA nitrite reductase, 2,4- 6-phospho- reductase: kinase: pdxK tetrahydrofolate diaminopimeloyl- [+ 2 isozymes] 3-oxoacyl- adenine 3-oxoacyl- oxygen- reductase 1, [acyl-carrier- reductase: 2+ 2+ CoA cofactor biosynthesis redox reactions monophosphate diaminopimeloyl- transferase): kdtA I (low osmolarity) repair NirC protein: nirC phosphorylase: dihydroxyhept- beta- protein] protein] protein] Mg MgtA Mg pathway methionine 7,8-diaminopelargonic cyclohydrolase: folD aconitate hydrase B: acnB sucrose-6 molybdopterin insensitive protein] yafB bisC 7,8-dihydroneopterin MoO - D-alanyl-D-alanine [acyl-carrier- glgP glycosylase: [acyl- alpha subunit, reductase reductase reductase hypothetical adenosylcobalamin 2 HMP-P biosynthesis D-alanyl-D-alanine ethanol D-mannose α,α-trehalose cytoplasmic trehalase: treF protein: nitrite reductase 2-ene-1,7- glucosidase an N 10 - adenosyltransferase glutathione acid synthetase: bioA a tetrahydrofolate phospho-N- phospho-N- α aconitate hydrase 1: acnA phosphate D-glucopyranose biosynthesis protein] mutY carrier- NAD(P)H B1: nrdA (NADH): fabI reductase: putative biotin 3'-triphosphate molybdopterin (ThiJ) protein: thiJ 10 -Kdo-(2->6)- radC maltodextrin dioic acid A: bglA (NADH) (NADH) an oxidized protein: citG D-erythro-7,8- 1 (AdoMet an N -formyltetrahydrofolate acetylmuramoyl- degradation 6-phosphate trehalase: treA hydrolase: protein A: moaA (NAD(P)H) nitroreductase: a trans-delta2-cis,cis a cis,cis-fabG aldehyde formyltetrahydrofolate cofactor (7R,8S)-diaminononanoate acetylmuramoyl- lipid IV (E. coli) synthase protein] [+ 3 isozymes] : fabI : fabI sulfoxide thioredoxin molybdopterin- phosphomethylpyrimidine hydoxyethylthiazole A D-threo-isocitrate [+ 2 isozymes] subunit: nirD phosphorylase: aldolase: hpaI a 2'- a trans-delta2- a (2E,7Z)- 2+ 2+ 2'-(5''-triphospho- S-adenosyl- dihydroneopterin synthetase): metK pentapeptide pentapeptide D-mannopyranose S2567 I: fabB nfnB -9,21-C40:3-[acp] delta11,23-3- reductase: reductase Mg CorA Mg guanine kinase: thiD dihydrofolate:folylpolyglutamate serine 3-deoxy-D-manno- Macromolecule Modification glucokinase: glk malP an apurinic site synthase deoxyribonucleoside cis,cis-delta21,39- tetradeca-2,7- α-D-ribosyl)-3'- triphosphate kinase: thiM dethiobiotin transferase: mraY trehalose 6- galactose-1-epimerase (8S)-3',8-cyclo-7,8- (6R)-L-erythro-5,6,7,8- β-D-glucose oxo-C42:2-[acp] S1557 L-methionine glutathione oxidized synthetase; dihydrofolate hydroxymethyltransferase: glyA undecaprenyldiphospho-transferase: mraY 6-phosphate I: fabB MeOH 2: bisZ dephospho-CoA dinucleotide decaprenyl- octulosonic-acid isocitrate mannose-6- P hydrolase: β 5'-deoxyadenosine adenine within DNA tetrahydrobiopterin 5'-diphosphate 6-phosphate C58:3-[acp] dienoyl-[acp] aldehydo- biosynthesis epimerase: folX met SAH oxidoreductase: glutaredoxin: 4-methyl-5-(2- synthetase: bioD (mutarotase): galM β -D-glucose dihydroguanosine met succinate 7,8-dihydromonapterin biosynthesis HMP-PP synthetase: folC 10 diphospho-N- N-acetylmuramoyl-L- transferase (KDO dehydrogenase: icdA tRNA processing phosphate -D-fructofuranose D-glucopyranose 6-phosphate AMP α pyruvate biotin thioredoxin phosphooxyethyl)thiazole an N - treC 6-phosphate 5'-triphosphate [DNA] NMN a cis,cis-delta5,23- nitrite -D- semialdehyde D-mannose triphosphate glutathionylspermidine protein B: mobB gor grxA a 5,10- acetylmuramoyl- alanyl-γ-D-glutamyl-meso transferase): kdtA putative aldose-1- a maltodextrin a cis,cis- a heme CcmA a heme reductase: met dethiobiotin formyltetrahydrofolate isomerase: 3-oxo-C42:2-[acp] glucopyranose biosynthesis methylenetetrahydrofolate pentapeptide -2,6-diaminopimeloyl- α α 2-oxoglutarate epimerase: yihR delta19,37-3- trxB methionine tetrahydropteroyltriglutamate molybdopterin- thiamin biosynthesis a tetrahydrofolate dihydrofolate:folylpolyglutamate -Kdo-(2->4)- -Kdo- a polycistronic manA α-D-glucopyranose β-D-glucopyranose 1-phosphate a holo [citrate glucokinase: adenosyltransferase methyltransferase: metE biotin synthesis, D-alanyl-D-alanine (2->6)-lipid IV (E. coli) tRNA precursor F6P oxo-C56:2-[acp] S-adenosylhomocysteine guanine protein, thiazole synthetase; dihydrofolate A lyase acyl- glutathione spermidine GSSG UDP-N- D-glucopyranose glk 1 (AdoMet B12-dependent nucleosidase: pfs dinucleotide moiety: thiE sulfur insertion?: bioB synthetase: folC D-glucopyranose F6P a heme CcmC a heme carrier protein] D-threo-7,8- acetylglucosamine:N- 6-phosphate superpathway of N-acetylglucosamine, Amine and Polyamine Degradation a reduced synthetase): metK homocysteine-N5- biosynthesis an N 10 - decaprenyl- UDP-N-acetyl-α-D-muramoyl- a cis,cis- γ a debranched a 3- a cis,cis- a cis,cis- citrate lyase dihydroneopterin a 5,10- RNase 4-aminobutanoate a [DNA]-3'- + a 6,7- 5'-chloro-5'- dihomo - thioredoxin SAM glutathionylspermidine methyltetrahydrofolate guanylyl 9-mercaptodethiobiotin acetylmuramyl- N-acetylmannosamine and N- di-trans,octa-cis- a 2,3,4-saturated 2- a 2,3,4-saturated a cis,cis-delta3,15- maltoheptaose NADP a reduced H O a (7Z)-hexacos- carbonic acid protein A: mobA methylenetetrahydrofolate formyltetrahydrofolate pyrophosphoryl-(N E: rne RNase degradation II L-alanyl-γ-D-glutamyl-L- a malonyl-[acp] hydroxyl delta13,31- a malonyl-[acp] dihydropteridine deoxyadenosine linolenoyl-CoA 2 α-limit dextrin oxodocosanoyl- delta13,31- delta11,23- synthetase S-ribosyl-L- thiamine phosphate (pentapeptide) Respiration acetylneuraminate degradation undecaprenyl phosphate fatty acyl-[acp] C34:2-[acp] flavodoxin maltodextrin 7-enoyl-[acp] dIDP synthetase/amidase: gsp transmethylase: metH L-homocysteine molybdenum -acetylglucosamine) E: rne lysyl-D-alanyl-D-alanine lysophosphatidate C50:2-[acp] oxygen- [acp] 3-hydroxy C42:2-[acp] (citrate (pro- homocysteine biotin synthesis, pyrophosphoryl- phosphorylase: 3-oxoacyl- enoyl-[acyl- enoyl-[acyl- a heme CcmD a heme cofactor -N-acetylmuramyl- a tRNA precursor N-acetylneuraminate insensitive C50:2-[acp]3-oxoacyl- 3S)-lyase thiamin- sulfur insertion?: bioB undecaprenol N- 4-aminobutanoate maltodextrin purine-nucleoside acyl-CoA [acyl-carrier- carrier- carrier- putative nucleoside (pentapeptide) 2-oxoglutarate decarboxylation to succinyl-CoA with a 5' RNase N-acetylneuraminate putative ferredoxin- NAD(P)H malP ligase: citC 5,6,7,8- glutathionylspermidine GABA phospho-N- 1-acyl-sn-glycerol- 3-oxoacyl- phosphorylase: 3-oxoacyl- protein] [acyl-carrier- protein] protein] diphosphate monophosphate acetylglucosamine extension and D: rnd β lyase (aldolase) exodeoxyribonuclease phosphorylase: thioesterase carbonic tetrahydromonapterin biotin a tRNA precursor Fatty Acid and Lipid Degradation fatty acid -oxidation I (generic) transaminase: acetylmuramoyl- NADP nitroreductase: glycogen protein] an acetyl-holo kinase: thiL transferase: murG a [2-oxoglutarate triacylglycerol 3-phosphate [acyl-carrier- VIII: S1955 malP [acyl- deoD II: tesB reductase: reductase reductase anhdrase: kinase: ndk a long 3' trailer with a 5' : nanA gabT pentapeptide reductase: nfnB phosphorylase: reductase: a heme CcmB a heme [citrate lyase acyl- lipid II (meso dehydrogenase degradation N-acetyl-D- acyltransferase: protein] glycogen carrier- a (3R)-3-fabG (NADH) (NADH) yadF S-ribosylhomocysteine extension and a transferase: mraY [+ 3 isozymes] fpr glgP thiamine diphosphate a peptidoglycan 6 2-oxoglutarate dehydrogenase a (3Z)-alk-3-enoyl-CoA mannosamine N-acetylglucosamine 4-aminobutyrate plsC synthase protein] dihydropteridine a cis,cis-fabG : fabI : fabI dITP carrier protein] lyase: ygaG diaminopimelate E2 protein] N phosphorylase: 5-chloro-5- γ α-D- hydroxydocosanoyl- a trans-delta2- a (2E,7Z)- short 3' extension a triacyl-sn degradation II reductase: hmpA di-homo- - delta13,31-3- dimer containing) -lipoyl-L-lysine (dihydrolipoyltranssuccinase aminotransferase: I: fabB glgP synthase deoxyribose [acp] cis,cis-delta11,23- hexacosa-2,7- lipid II (meso -glycerol a [DNA]-3'- a 2'- a 5,6,7,8- adenine linolenate glucopyranose oxo-C50:2-[acp] (mycobacteria) E2 component): sucB 4-enzyme protein, putative N-acetyl-D- goaG undecaprenyl-diphospho-N- UMP NADPH an oxidized H + I: fabB CO H O Fe 2+ FeoB Fe 2+ succinate deoxyribonucleoside 1-phosphate 1-phosphate C42:3-[acp] dienoyl-[acp] 2 2 diaminopimelate 2-oxoglutarate dehydrogenase RNase acetylmuramoyl-L-alanyl-γ-D- a 2,3,4-saturated 1,2-diacyl- hydroxyl tetrahydropteridine 2-oxoglutarate tRNA 3-hydroxyacyl-CoA lipase: yhjY N-acetyl-D- glucosamine semialdehyde α-D- flavodoxin containing) N-acetyl-D- sn-glycerol 3-phosphate a cis,cis-delta5,17- 5'-monophosphate (dihydrolipoyltranssuccinase dehydrogenase D: rnd RNase nucleotidyl dehydrogenase; putative mannosamine glutamyl-L-lysyl- D-alanyl-D-alanine maltohexaose a cis,cis- glucosamine L-carnitine degradation I glucopyranose E2 component): sucB D: rnd a tRNA precursor 3-hydroxybutyryl- 6-phosphate 3-oxo-C36:2-[acp] Fatty Acid and Lipid Biosynthesis Carbohydrate Biosynthesis (decarboxylase transferase: lipase: 1-phosphate delta15,33-3- 2+ 2+ a peptidoglycan a peptidoglycan with a short kinase: ycfX Fe FeoA Fe [+ 2 isozymes] component): sucA cca CoA epimerase; ybaC N-acetyl-D- oxo-C52:2-[acp] with L,D with D,D lipid II (meso 3' extension a 1,2-diacyl- glucosamine [+ 2 isozymes] delta(3)-cis-delta(2) L-carnitine palmitate biosynthesis (type II fatty acid synthase) gluconeogenesis I cross-links cross-links a [2-oxoglutarate a [2-oxoglutarate sn-glycerol succinate lipid A-core biosynthesis (E. coli K-12) (5Z)-dodecenoate superpathway of fatty acid biosynthesis initiation (E. coli) ADP-L-glycero-β- CMP-3-deoxy-D-manno- GDP-mannose biosynthesis diaminopimelate a tRNA -trans-enoyl-CoA 6-phosphate trehalose biosynthesis I tRNA N-acetyl-D- α a cis,cis- a 3-oxohexacosanoyl- (mycobacteria) (mycobacteria) containing) dehydrogenase dehydrogenase N-acetylglucosamine- UDP-N-acetyl- -D- an oxidized β-D-glucose N-monoacetylchitobiose 5'-deoxy-5'- (+)-7-epi- a 3- a cis,cis-delta9,27- a cis,cis- a (1->4)- 3+ 3+ biosynthesis I D-manno-heptose octulosonate biosynthesis precursor with isomerase; enoyl- glucosamine probable di-trans,octa-cis- a cis,cis-delta7,25- maltopentaose H O a (5Z)-tetracos- Fe SitC Fe α α 6 6 nucleotidyl 4-enzyme protein, γ H O 2 α -D-Kdo-(2->4)- -D- (S)-malate D-glucopyranose E2 protein] N E2 protein] N -S- CoA hydratase: fadB 6-phosphate muramoyl-L-alanyl- -D- 2 a malonyl-[acp] factor 420 6-phosphate 6'-phosphate delta11,29- a malonyl-[acp] a tRNA precursor fluoroadenosine jasmonoyl-CoA [acp domain within oxodocosanoyl- 3-hydroxyC46:2- delta17,35- -D-glucan an acetoacetyl-[acp] biosynthesis D-glucopyranose a 5' extension RNase 6-phosphate crotonobetaine/ undecaprenyl phosphate GTP C44:2-[acp] 5-enoyl-[acp] alpha- IDP Kdo-(2->6)-lipid A (E. coli) a (3R)-3- acetyl-CoA UDP-α-D-glucose -dihydrolipoyl- succinyldihydrolipoyl- transferase: 3-hydroxyacyl-CoA deacetylase: agaA glutamyl-L-lysyl-D-alanine C48:2-[acp] a fatty acid synthase]3-oxoacyl- [acp] [acp] C54:2-[acp] D-sedoheptulose D-ribulose 5-phosphate 6-phosphate 6-phosphate D: rnd N-acetylglucosamine- carnitine-CoA 3-oxoacyl- 3-oxoacyl- enoyl-[acyl- enoyl-[acyl- glucosephosphate L-lysine L-lysine cca dehydrogenase; amylase: 3-oxoacyl-[acyl- heptosyl hydroxydecanoyl-[acp] 7-phosphate D-arabinose a (2E)-2-enoyl-CoA 4-enzyme protein, a 2-acylglycerol N-acetylglucosamine- maltodextrin 6-phospho- purine-nucleoside acyl-CoA [acyl-carrier- [acyl-carrier- [acyl-carrier- carrier- carrier- nucleoside beta- α 3-hydroxybutyryl- 6-phosphate ligase: caiC glucose-6- malS 3+ 3+ phosphoheptose 5-phosphate isomerase: pgi UDP- -D-galactose RNase phospho-N- 3-oxoacyl- 3-oxoacyl- protein] protein] protein] diphosphate Fe FhuC Fe carrier-protein] transferase I: rfaC hydroxydecanoyl BCCP-biotin: accB 3-oxoacyl-[acyl-carrier- 3-hydroxyacyl-CoA deacetylase: agaA 6-phosphate superpathway of 4- phosphoanhydride phosphate phosphorylase: beta- RNase phosphorylase: thioesterase protein] protein] isomerase: gmhA isomerase: kdsD F6P biosynthesis PH: rph CoA epimerase; cytoplasmic reductase: fabG [+ 2 isozymes] protein] synthase D-glycero-D- aldehydo-D-arabinose Nucleoside and Nucleotide Biosynthesis dehydrogenase; deacetylase: nagA aminobutanoate degradation acetylmuramoyl- phosphorylase; [acyl-carrier- malP glucosidase [acyl- D: rnd deoD II: tesB reductase: reductase: reductase: reductase reductase kinase: ndk heptosyl-Kdo -lipid A thioester delta(3)-cis-delta(2) N-acetylglucosamine- dehydrogenase: alpha- 2 III; acetyl CoA ACP manno-heptose 3-hydroxybutyryl- D-glucosamine pentapeptide pH 2.5 acid protein] carrier- a (3R)-3-fabG fabG fabG (NADH) (NADH) a (3R)-3- dehydrase, trans- malate 5-phosphate mannose-6- α,α-trehalose UDP-α-D-glucose 2-oxoglutarate dehydrogenase -trans-enoyl-CoA 6-phosphate zwf glycogen A: bglA a (3R)-3- a cis,cis- (R)-carnitinyl-CoA 4-aminobutanoate transferase: mraY phosphatase: appA synthase protein] : fabI : fabI amylase: ITP hydroxybutanoyl-[acp] ADP-heptose--lps 2-decenoyl-ACP transacylase: fabH 7-phosphate phosphate 6-phosphate UDP-galactose-4- CoA epimerase; glycerol 6-phosphate l-carnitine phosphorylase: 5-fluoro-5- hydroxyhexacosanoyl- hydroxydocosanoyl- delta9,27-3- a trans-delta2- a (2E,5Z)- putative iron malonyl-CoA putative dehydrogenase: superpathway of purine nucleotides de novo biosynthesis II (dihydrolipoyltranssuccinase isomerase; enoyl- deacetylase: nagA I: fabB (+)-7-epi- amyA heptosyltransferase superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) CMP a 2,3,4-saturated fatty acid delta(3)-cis-delta(2) a 2,3,4-saturated (3R GABA transaminase: gabT glgP synthase a nucleoside 5'- [acp domain within [acp] oxo-C46:2-[acp] cis,cis-delta17,35- compound isomerase: fabA enzyme: mdh malate isomerase: trehalose-6- epimerase: galE superpathway of guanine and guanosine salvage E2 component): sucB queuosine acyl-CoA CoA hydratase: fadB D-glucosamine dehydratase: 6-phospho N-acetyl-D- adenine deoxy-D-ribose jasmonate tetracosa-2,5- a (1->4)- (3R)- UDP-α-D-galactose phosphorylation -trans-enoyl-CoA )-3-hydroxyacyl-CoA 4-aminobutyrate undecaprenyl-diphospho-N UMP a reduced D-glucosamine I: fabB a tRNA a fatty acid synthase] II: rfaF malonyl-CoA-[acyl- S0868 manA caiB GDP H + D-glucono- glucosamine monophosphate 1-phosphate C54:3-[acp] dienoyl-[acp] α-D-glucan ABC hydroxymyristol (3R)- an acetyl-[acp] malate dehydrogenase: D-arabinofuranose phosphate PRPP CTP 2-oxoglutarate biosynthesis I (de novo) synthetase, long- 6-phosphate aminotransferase: goaG -acetylmuramoyl-L-alanyl-γ- phosphate factor 420 Fe 3+ Fe 3+ carrier-protein] D-glycero-β-D- CMP putative acyl-CoA isomerase; enoyl- α-D- 6-phosphate transporter acyl carrier (heptosyl) -Kdo -lipid A hydroxymyristol [+ 39 isozymes] dehydrogenase mdh 5-phosphate D-mannopyranose phosphatase: gln dehydrogenase chain-fatty-acid-- α-D-glucosamine succinate semialdehyde D-glutamyl-L-lysyl- D-alanine a cis,cis-delta9,27- 1,5-lactone maltotetraose 2 2 transacylase: fabD dehydrogenase: yafH CoA hydratase: fadB manno-heptose 6-phosphate otsB hydrogencarbonate guanosine cytidylate an uncharged preQ glucopyranose a cis,cis- permease protein acyl carrier (oxaloacetate- [+ 39 isozymes] 2-dehydro-3- amidophosphoribosyltransferase, (decarboxylase 0 CoA ligase: fadD a 2,3,4-saturated (3S 6-phosphate 3-oxo-C46:2-[acp] 1,7-bisphosphate kinase: cmk 4-enzyme protein, γ 1-phosphate delta13,31-3- protein dehydratase: fabZ protein decarboxylating) phosphomannomutase: PRPP amidotransferase: purF component): sucA tRNA a 2,3,4-saturated fatty acyl CoA -butyrobetainyl- crotonobetainyl- succinate semialdehyde putative deoxyphosphooctulonate α α CDP )-3-hydroxyacyl-CoA glucosamine- 3+ 3+ a malonyl-[acp] , -trehalose 3-hydroxyacyl-CoA fatty acid β-oxidation III α-D-glucosamine CoA CoA dehydrogenase, NAD + oxo-C50:2-[acp] Fe SitB Fe dehydratase: fabZ (NADP+): sfcA aldolase: kdsA cpsG 5-phospho-β- carbamoyl-phosphate CDP 6-phosphate phosphatase: gly nucleoside dehydrogenase; (unsaturated, odd number) 6-phosphate -dependent: aldA a (2E)-but-2-enoyl-[acp] glucosyl-(heptosyl) a (2E)-dec-2-enoyl-[acp] α synthase, arginine purine-nucleoside preQ yaeD -D-mannose D-ribosylamine 1 3-hydroxybutyryl- deaminase: -Kdo -lipid A D-glycero-β-D- KDO-8P specific: carB carA ribonucleoside phosphorylase: diphosphate a (3Z)-alk-3- glucosamine- (1S,2R)-1- a cis,cis- a 3-oxotetracosanoyl- a cis,cis-delta9,21- a cis,cis- 2 2 3-oxoacyl-[acyl-carrier-3-oxoacyl-[acyl-carrier- 1-phosphate ribonucleoside coenzyme A CoA epimerase; nagB succinate a [formate C acetyltransferase]-glycine a cis,cis-delta9,27- a glycogen (S)-carnitinyl-CoA H O a RNA-DNA hybrid palmitoyl-CoA H O a 3-oxoicosanoyl- an acyl-[acyl- diphosphate deoD kinase: ndk 6-phosphate arsenate a purine a malonyl-[acp] 2 2 + + enoyl-[acyl- manno-heptose diphosphate inosine- superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass tRNA-guanine 4-enzyme protein, enoyl-CoA a reduced flavodoxin SAM ser C-(indol-3- delta11,23- a malonyl-[acp] ATP asp [acp domain within 3-hydroxyC40:2- delta13,31- a protein GMP K TrkA K protein] synthase protein] synthase I: fabB oxaloacetate mannose-1-phosphate phosphoribosylglycinamide delta(3)-cis-delta(2) 4-enzyme deaminase: C46:2-[acp] [acp] carrier protein] carrier-protein] 1-phosphate 3-deoxy-D-manno reductase 1, UDP guanosine CTP transglycosylase: tgt 3-hydroxyacyl-CoA F6P ribonucleoside yl)glycerol C42:2-[acp] a fatty acid synthase]3-oxoacyl- [acp] C50:2-[acp] III; acetyl CoA ACP 3-oxoacyl-[acyl-carrier- guanylyltransferase: synthetase, GAR asp reductase guanine-hypoxanthine -trans-enoyl-CoA probable 3-oxoacyl- 3-oxoacyl- enoyl-[acyl- enoyl-[acyl- periplasmic reductase carbamoyl phosphate alpha subunit, kinase: gsk a 7-aminomethyl-7- protein, 3- nagB 3-phosphate glucosyl-(heptosyl) - transacylase: fabH protein] synthase II: fabF -octulosonate UDP-N-acetyl-α-D- synthetase: purD 1: nrdB nrdA phosphoribosyltransferase: gpt D-glucopyranose 6-phosphate dehydrogenase; carnitine operon maltodextrin acyl-CoA [acyl-carrier- [acyl-carrier- [acyl-carrier- carrier- carrier- serine GMP 2 pyruvate cpsB ribonucleoside- 34 isomerase; enoyl- hydroxyacyl-CoA probable (NADH): fabI phosphoenolpyruvate 8-phosphate B1: nrdA ribonucleoside guanine deazaguanosine 3-hydroxybutyryl- oxidoreductase: probable pyruvate 3-oxoacyl- RNase 2,3- protein] reductase: Kdo -lipid A-phosphate a (3Z)-dec-3-enoyl-[acp] α mannosaminouronate formate [+ 4 isozymes] F6P phosphorylase: 3-oxoacyl- thioesterase protein] protein] protein] protein] protease Do, + + 2 GDP- -D- hypoxanthine CoA hydratase: fadB purine-nucleoside tryptophan crotonobetaine/ K KdpC K carboxylase: ppc phosphatase: [+ 2 isozymes] diphosphate in tRNA CoA epimerase; dehydrogenase; formate lyase activating [acyl-carrier- T: rnt dihydroxybenzoate- guaC ADP-D-glycero-β- biosynthesis aspartate diphosphate phosphoribosyltransferase: hpt glucosephosphate Degradation/ caiA phosphorylase: malP [acyl- II: tesB reductase: reductase: reductase: reductase reductase heat shock a butanoyl-[acp] mannose UDP-N-acetyl- GAR reductase 2, a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated 3-oxoacyl-CoA 3-hydroxybutyryl- enzyme 2: pflC synthase: carnitine-CoA 3-oxoacyl-[acyl- an acetoacetyl-[acp] phosphoenolpyruvate phosphoenolpyruvate D-manno-heptose kdsC reductase 1, isomerase: pgi probable S- delta(3)-cis-delta(2) protein] carrier- AMP ligase: entE fabG fabG fabG (NADH) (NADH) protein α carbamoyltransferase: dCDP beta chain: nrdF Utilization/ CoA epimerase; deoD trpB trpA glycogen ligase: caiC a (3R)-3- a cis,cis- a (3R)-3- carrier-protein] carboxykinase: pckA synthase: ppsA -D-glucosamine anaerobic alpha subunit, adenosylmethionine:tRNA -trans-enoyl-CoA [+ 2 isozymes] synthase protein] IMP 3-oxoacyl-[acyl- acyl-CoA hydrolysis ADP-L-glycero-D- α UDP-N-acetyl pyrI pyrB Assimilation - Other phosphorylase: hydroxytetracosanoyl- delta9,21-3- hydroxyicosanoyl- a trans-delta2-: fabI a trans-2-: fabI HtrA: htrA -Kdo phosphoribosylglycinamide ribonucleoside delta(3)-cis- a nucleoside 5'- + + glucosyl-(heptosyl) - synthase I: fabB glucosamine-2- ribonucleoside- B1: nrdA GMP F6P ribosyltransferase- isomerase; enoyl- I: fabB synthase DNA palmitate K KefB K carrier-protein] 3 mannoheptose-6- formyltransferase 2: purT nucleoside delta(2)-trans- D-glyceraldehyde glgP [acp domain within oxo-C40:2-[acp] [acp] cis,cis-delta13,31- enoyl-[acyl- a peptide Kdo -lipid A-phosphate triphosphate diphosphate isomerase: queA acetoacetate CoA hydratase: fadB a [formate C acetyltransferase]- ribose-1-arsenate I: fabB monophosphate (L-aspartyl) synthase II: fabF 2 a (5Z)-3-oxododec- a 2,3,4-saturated phosphoenolpyruvate epimerase: rfaD CTP:CMP-3- epimerase:α wecB diphosphate [+ 2 isozymes] 5'-deoxyadenosine a purine base 3-phosphate trp D-carnitine a fatty acid synthase] C50:3-[acp] carrier protein] UDP-N-acetyl- - reductase 6-phosphofructokinase 34 degradation enoyl-CoA a flavodoxin semiquinone met adenylate fatty acyl CoA β deoxy-D-manno- N-carbamoyl-L-aspartate reductase: nrdD an epoxyqueuosine glycin -2-yl radical 3-oxoacyl-[acyl- 5-enoyl-[acp] ADP-L-glycero- - D-mannosamine FGAR kinase: ndk (to acetyl CoA) isomerase; α-D- 1: nrdB nrdA fructose- II: pfkB in tRNA a cis,cis-delta11,29- maltotetraose fatty acid biosynthesis octulosonate UTP a cis,cis- + + carrier-protein] 3-oxoacyl-[acyl- D-manno-heptose UDP-N-acetyl-D- enoyl-CoA glucopyranose K KefC K initiation II acyl-CoA enolase: eno transferase: kdsB phosphoribosylformyl- bisphosphatase: fbp 6-phosphofructokinase acetoacetate 3-oxo-C48:2-[acp] glucosyl-(heptosyl) -Kdo dCTP dUDP hydratase: fadB 1-phosphate delta13,25-3- synthase I: fabB 3 2 carrier-protein] mannosaminuronic dihydro-orotase: pyrC I: pfkA thioesterase glycineamide anaerobic putative coat a (2E)-2- oxo-C44:2-[acp] -lipid A-bisphosphate reductase: fabG CMP-Kdo acid dehydrogenase: superpathway of pyrimidine adenine and adenosine salvage I acetyl-CoA Inorganic Nutrient Metabolism acetyl-CoA II: tesB 2-phospho-D-glycerate synthetase, FGAM 2-deoxycytidine nucleoside ribonucleoside- protein: S0240 enoyl-CoA a 3-oxohexanoyl-[acp] wecC nucleobases salvage β-D-fructose 1,6-bisphosphate a queuosine 34 a (3R,5Z)-3-hydroxydodec- 3-oxoacyl-[acyl- synthetase: purL (S)-dihydroorotate acetoacetyl-CoA K + KdpA K + UDP-N-acetyl-α-D- 5-triphosphate diphosphate triphosphate DHAP in tRNA a 5'-half-tRNA N-acetyl-α- a (1->4)- 5-enoyl-[acp] carrier-protein] a 2,3,4-saturated phosphoglyceromutase uracil superpathway of sulfate assimilation D-cellobiose crotonobetainyl- a (1->4)- a [DNA]-3'- a 5'-phospho- a [protein]-L- a (9Z)-3- a cis,cis- 3-oxoacyl-[acyl- deaminase: dcd kinase: ndk reductase: nrdD putative epimerase/ phospholipases phosphate acquisition sulfite glycerophosphoglycerol a cis,cis-delta19- H O stearoyl-CoA H O a cis-delta15- ATP RNA α coenzyme A 1: gpmA mannosaminuronate FGAM adenosine and cysteine biosynthesis 6'-phosphate a malonyl-[acp] a 3'-half-tRNA molecule with 2 α-D-glucan D-muramoyl- 2 proline (ω = 180) a dodecanoyl-[acp] oxohexadec- delta13,25- -D-glucan galactosyl-glucosyl- synthase III; fatty acid glycogen biosynthesis I (from ADP-D-Glucose) dihydro-orotate uracil thiolase I, 37-C56:2-[acp] CoA hydroxyl [DNA] C34:1-[acp] carrier-protein] (3R)- O-antigen building blocks biosynthesis (E. coli) purine-nucleoside aldolase: sgaE a 2',3'-cyclic L-alanine(1-) peptidyl-prolyl 1,4-alpha- (heptosyl) -Kdo - acetyl CoA ACP [+ 2 isozymes] dehydrogenase: pyrD phosphoribosyltransferase: upp triosephosphate 3-ketoacyl- a 1-phosphatidyl- molecule with enoyl-[acyl- 9-enoyl-[acp]3-oxoacyl- C44:2-[acp]enoyl-[acyl- enoyl-[acyl- reductase: fabG 3 2 hydroxymyristol phosphoribosylaminoimidazole dUTP [+ 3 isozymes] a phosphate glucan K + TrkH K + transacylase: fabH UDP-α-D- α D-glucopyranose PRPP UMP phosphorylase: 1D-myo-inositol a phosphatidylcholine a phosphatidylcholine a phosphatidylcholine a phosphatidylcholine sulfate 3-phospho-D-glycerate a 5'-OH end phosphate end cis-trans lipid A-bisphosphate acyl carrier -D- D-glucopyranose orotate isomerase: tpiA CoA thiolase, monoester sulfite reductase, glycerophosphodiester cryptic probable glycogen DNA acyl-CoA carrier- [acyl-carrier- carrier- carrier- poly(A) branching a (3R)-3- 3-phospho-D-glycerate synthetase, AIR synthetase: purM deoD 4,5-bisphosphate diadenosine 3-oxoacyl-[acyl- N-acetylmuramoyl- isomerase UDP-D- protein an acetyl-[acp] galactose glucopyranose 6-phosphate 6-phosphate superpathway of adenosine deoxyuridinetriphosphatase: dut cytidylate kinase: cmk superpathway of glycolysis and the Entner-Doudoroff pathway acetyl-CoA outer membrane sulfate alpha subunit: cysI phosphodiesterase: glpQ crotonobetaine/ phosphorylase: ligase: lig thioesterase protein] protein] protein] protein] polymerase hydroxyhexanoyl-[acp] adenine D-3- tetraphosphatase: phospho-beta- C (rotamase enzyme: galactose:(glucosyl) 1-phosphate glucosephosphate transferase: carrier-protein] putative carnitine-CoA glgP l-alanine II: tesB reductase reductase: reductase reductase dehydratase: fabZ phosphoglycerate glucose-1-phosphate putative PRPP biosynthesis AIR orotate nucleotides de novo biosynthesis I uridylate kinase: pyrH D-glyceraldehyde 3-phosphate phospholipase adenylyltransferase: phosphoglycerate aphA putative sulfite glycerophosphodiester glucosidase; [+ 2 isozymes] C): ppiC I: pcnB glgB lipopolysaccharide- isomerase: pgi synthase I: fabB amidase I: amiA (NADH): fabI fabG (NADH) + Kup K + (3R)- 3-oxoacyl-[acyl- kinase: pgk UDP-Galf phosphoglucomutase: phosphoribosyltransferase: dUMP D-glucopyranose fadA A: pldA cysD cysN dehydrogenase: serA phosphodiesterase: ugpQ cryptic: celF tRNA ligase: caiC maltodextrin a (3R,9Z)-3- (NADH) K a (2E,5Z)-dodeca- thymidylyltransferase: rffH UDP a 1,2-diacyl- phosphate reductase: yccK a (2E)-dodec- starch hydroxymyristol alpha-1,3-D- carrier-protein] F6P mrsA D-ribose 5- phosphoribosylaminoimidazole adenine glyceraldehyde- 6-phosphate ligase: phosphorylase: [+ 4 isozymes] hydroxyhexadec- : fabI : fabI 3,5-dienoyl-[acp] glucose-1-phosphate pyrE asp thymidylate a 1,2-diacyl- a phosphatidate [+ 2 isozymes] a [protein]-L- a trans-delta2- a trans-delta2- acyl carrier galactosyltransferase: synthase I: fabB phosphate carboxylase; AIR carboxylase, IMP nucleoside phosphoribosyltransferase: apt 3-phosphate acetyl-CoA a 2-lysophosphatidylcholine a fatty acid sn-glycerol a 1-lysophosphatidylcholine APS 3-phosphooxypyruvate ybeU N-acetyl-D- stearate 2-enoyl-[acp] RNA 13-DPG thymidylyltransferase: L-glutamine:D- phosphoglucomutase: synthetase: thyA adenine and adenosine salvage III sn-glycerol a cis,cis-delta21,39- malP [DNA] proline (ω = 0) 9-enoyl-[acp] cis,cis-delta13,25- cis-delta15- protein waaL enoyl-[acyl- phosphoribosylpyrophosphate CO(2)-fixing subunit: purK diphosphate kinase: ndk dehydrogenase A: gapA glycerol sn-glycerol ala muramate 3-oxoacyl-[acyl- pgm hydrogen sulfide an oxidized ferredoxin H O crotono-betaine C44:3-[acp] C34:2-[acp] + + rfbA fructose-6- synthetase: prsA adenosine 5- 3-phosphoserine 2 3-oxo-C58:2-[acp] K Kch K dehydratase: fabZ galactosyl-(glucosyl) carrier-protein] dTDP-α-D-glucose α orotidine 5'-phosphate dTMP AMP glucose-6- [iron-sulfur] cluster 3-phosphate D-glucopyranose carrier-protein] glyceraldehyde- phosphate -D- N5-CAIR UTP phosphosulfate D-glucopyranose a 2'-phospho- a (1->4)- α-D- -(heptosyl) -Kdo - reductase PRPP adenylosuccinate 13-DPG phosphate aminotransferase: 6-phosphate 2 3 2 synthase II: fabF 3-phosphate dTDP- aminotransferase: glucopyranose thymidylate adenine kinase: cysC [ligated tRNA] α-D-glucan glucopyranose a (2E)-hex-2-enoyl-[acp] lipid A-bisphosphate (NADH): fabI orotidine-5-phosphate synthetase: purA CTP synthetase: pyrG dehydrogenase: serC dehydrogenase glmS 1-phosphate phosphoribosylaminoimidazole kinase: tmk 1-phosphate glucose 4,6- purine-nucleoside Nucleoside and Nucleotide Degradation an acetoacetyl-[acp] triosephosphate A: gapA glucose-1-phosphate carboxylase; AIR carboxylase, decarboxylase: pyrF putative phosphoglycerate zwf PAPS D-ribose RbsD D-ribose a (5Z)-dodec-5-enoyl-[acp] dehydratase: D-glucosamine adenylo-succinate glucosephosphate O-phospho-L-serine enoyl-[acyl- isomerase: tpiA catalytic subunit: purE phosphorylase: deoD CTP kinase: pgk D-glyceraldehyde rffG adenylyltransferase: UMP thymidylate 38- 6-phosphate adenine and adenosine salvage II isomerase: pgi sulfite reductase, cob(I)yrinate a,c-diamide- a peptidoglycan a uridine a cis,cis-delta7,25- a (7Z)-3- a cis,cis- uridine 2552 carrier-protein] galactosyl-(glucosyl) DHAP 3-phosphate glgC kinase: yceG adenosine superpathway of pyrimidine ATP glycerophosphoserine a peptide with a a tripeptide hexulose 6- a uracil in DNA methionol a 3-oxooctadecanoyl- a cis-delta11- citrate dTDP- adenylosuccinate 6-phospho adenosine superpathway of purine deoxyribonucleosides degradation guanosine DMAPP an adenosine 37 in tRNA dimer (generic) 40 in tRNA 3-hydroxyC44:2- oxohexacos- delta11,29- reductase -(heptosyl) -Kdo - phosphoglucosamine CAIR cytidylate kinase: cmk 3-phospho-D-glycerate deoxyribonucleosides degradation alpha subunit: cysI 3-phosphoserine [corrinoid adenosyltranferase] leader sequence phosphate [acp] C30:1-[acp] in 23S rRNA 3 3 2 a (1->4)- D-glucono- alcohol pseudouridylate aconitate D-ribose RbsC D-ribose (NADH): fabI glucose 4,6 mutase: S2704 ADP-α-D-glucose uridylate kinase: pyrH lyase: purB dTDP nucleotides nucleotides [+ 2 isozymes] phosphatase: serB 3-oxoacyl- [acp] 3-oxoacyl- 7-enoyl-[acp]3-oxoacyl- C48:2-[acp]enoyl-[acyl- enoyl-[acyl- cell lipid A-bisphosphate α-D-glucan purine-nucleoside 1,5-lactone dehydrogenase: synthase I: truA hydrase dehydratase: phosphoribosylaminoimidazole- phosphoglyceromutase 2'-deoxycytidine degradation II degradation III [acyl-carrier- [acyl-carrier- [acyl-carrier- division putative α-D-glucosamine glycogen UDP nucleoside phosphorylase: deoD adenosine phosphoglyceromutase cob(I)yrinic acid glycerophosphodiester membrane-bound putative uracil-DNA- carrier- carrier- a hexanoyl-[acp] fatty acid biosynthesis rfbB succinocarboxamide synthetase, AMP 1: gpmA 6-phosphogluconolactonase: sulfite delta(2)- leader peptidase probable adhP tRNA protein] 1: acnA protein: 1-phosphate diphosphate 1: gpmA AMP 2'-deoxyguanosine ser a,c-diamide phosphodiesterase: glpQ lytic murein peptidase glycosylase: protein] protein] protein] protein] initiation III epimerase/ synthase: SAICAR synthetase: purC adenosine deaminase: add phosphoglyceromutase cytidine/ isopentenylpyrophosphate hexulose-6- pseudouridine aconitate ftsJ lipid IV biosynthesis (E. coli) dTDP-4-dehydro- UDP-α-D-glucose ybhE GMP adenosyltransferase: (signal transglycosylase T: pepT ung putative reductase: reductase: reductase: reductase reductase a 2'-O- GlcNAc AgaD GlcNAc core oligosaccharide-lipid A aldolase: sgaE N-acetyl glgA adenylate kinase: ndk [+ 2 isozymes] deoxycytidine 2'-deoxyadenosine sulfite reductase- glycerophosphodiester 3-oxoacyl-[acyl- α 2: gpmB tRNA-adenosine peptidase I): lepB phosphate aldehyde 5S synthase: fabG hydrase 2552 6-deoxy- -D- biosynthesis SAICAR ribonucleoside- D-gluconate (NADPH): cysI cysJ serine btuR C: mltC a (3R)-3- a cis,cis-fabG a (3R,7Z)-3-fabG (NADH) (NADH) methyluridine A (E. coli K-12 core type) [+ 3 isozymes] glucosamine- a (1->4)- kinase: adk dTTP inosine deaminase: cdd transferase: miaA phosphodiesterase: ugpQ synthase: truB B: acnB carrier-protein] a (3R)-3- a malonyl-[acp] glucopyranose adenine 6-phosphate F6P thymidine acetyltransferase: reductase: : fabI : fabI in 23S rRNA 1-phosphate α-D-glucan D-glucopyranose diphosphate reductase 2-phospho-D-glycerate purine-nucleoside [+ 3 isozymes] 38- hydroxyoctadecanoyl- delta7,25-3- hydroxyhexacos- a trans-delta2- a trans-delta2- synthase II: fabF hydroxytetradecanoyl- UDP-N-acetyl- 3-oxoacyl-[acyl- adenosine putative sulfite cysE a proteinogenic sgaH an apyrimidinic uracil S1557 a pseudouridine D-threo-isocitrate lipopolysaccharide 1,2-N- dTDP-6-deoxy- 6-phosphate adenylosuccinate nucleoside 2, beta chain: nrdF ADP thymidine a dipeptide [acp] oxo-C44:2-[acp] 7-enoyl-[acp] cis,cis-delta11,29- cis-delta11- [acp] α-D-glucosamine carrier-protein] uridyltransferase: 1,4-alpha- 6-phosphogluconate 2'-deoxyuridine deoxyadenosine phosphorylase: deoD guanosine reductase: yccK adenosyl-cob(III) site in DNA 3-(methylsulfanyl) 40 in tRNA 3-oxoacyl-[acyl- β putative diphosphate kinase: ndk purine-nucleoside 6-phosphofructokinase a [corrinoid N 6 -(3-methylbut-2-en-1- sn-glycerol a peptide amino acid acetylglucosaminetransferase: -D-fructose 1,6- L-mannose- glmU glucan lyase: purB ribonucleoside diphosphate dehydratase: edd phosphorylase: deaminase: add triphosphate a leader sequence GlcNAc-1,6- propanal C48:3-[acp] C30:2-[acp] synthase I: fabB phosphoglucomutase: adenine enolase: eno purine-nucleoside O-acetyl-L-serine yrinate a,c-diamide 37 ser carrier-protein] bisphosphate dehydrogenase: phosphorylase: deoD fructose- II: pfkB purine-nucleoside hydrogen sulfide adenosyltransferase] yl)-adenosine in tRNA 3-phosphate a lipid II D-ribulose waaD UDP-N- an acetyl-[acp] N-acetyl-α-D- branching reductase 1: nrdB nrdA phosphoribosyltransferase: apt deoA phosphorylase: deoD anhydro-MurNAc- formaldehyde synthase I: fabB mrsA AICAR membrane- ribonucleoside- bisphosphatase: fbp 6-phosphofructokinase phosphorylase: purine-nucleoside 5-phosphate rfbC glucosamine KDGP pentapeptide acetylglucosamine fructose- enzyme: diphosphate deoD purine-nucleoside phosphorylase: core oligosaccharide- UDP dTDP-4-dehydro- phosphoglucomutase: bound ATP hypoxanthine I: pfkA uridine thymine taurine a 3-oxooctanoyl-[acp] acetyltransferase: 3-oxoacyl-[acyl- bisphosphatase: fbp 1-phosphate glgB phosphoribosylaminoimidazolecarboxamide gln AMP phosphoenolpyruvate 2'-deoxyinosine phosphorylase: deoD deoD cysteine synthase lipid A (E. coli K-12 core β-L-rhamnose pgm synthase: reductase β phosphorylase: adenosine inosine 5'- lpxA carrier-protein] α-D-glucopyranose formyltransferase, AICAR UTP dUDP -D-fructose 1,6- degradation IV UDP-N-acetyl-α-D- α 7,8- a [glutamine- N-acetyl atpI 2, alpha udp α phosphate B, O-acetylserine N-acetyl- -D-glucosaminyl- sn-glycero-3- an oxidized a single- a dipeptide with a a (2E)-hexacos-2-enoyl- a cis,cis-delta5,23- a (7Z)-3- a cis,cis- type with D-GlcNAc) F6P dTDP-L- a glycogen 1-phosphate guanine-hypoxanthine phosphoenolpyruvate pyruvate kinase II: pykA 2-keto-3- bisphosphateputative deaminase: add 2-deoxy- -D-ribose 1-phosphate an oxidized a primary alcohol H dihydroxyacetone a cis,cis-delta7,19- a cis-delta13- starch a 3-oxooctanoyl- 3-oxoacyl-[acyl- synthase I: fabB glucosamine- formyltransferase; IMP cyclohydrolase: purH nucleoside guanine sulfhydrolase B: cysM mannosaminuronate diphospho-ditrans,octacis dihydroneopterin ferredoxin [iron- 2 synthetase]- [acp domain within 3-hydroxyC42:2- oxotetradec- delta15,27- rhamnose [+ 10 isozymes] subunit: nrdE synthase: ppsA pyruvate kinase I: pykF thymidine degradation taurine cytochrome c phosphoethanolamine stranded RNA ATP C-terminal L-proline UDP-3-O-[(3R)-3- phosphoribosyltransferase: gpt deoxygluconate epimerase/ L putative C38:2-[acp] C32:1-[acp] [acp] carrier-protein] 3-oxoacyl-[acyl- 1-phosphate glucose-1-phosphate CTP synthetase: pyrG diphosphate kinase: ndk cysteine synthase -undecaprenol 3'-triphosphate sulfur] cluster L-tyrosine a fatty acid synthase] [acp] 7-enoyl-[acp] C46:2-[acp] glucosephosphate synthetase: FAICAR [+ 2 isozymes] 6-phosphate aldolase: phosphorylase: inosine taurine enoyl-[acyl- enoyl-[acyl- 3-oxoacyl- 3-oxoacyl- enoyl-[acyl- enoyl-[acyl- reductase: fabG hydroxymyristoyl]-N- carrier-protein] uridyltransferase: uridylyltransferase: hypoxanthine phosphopentomutase: deoB dihydroxyacetone α rfbD rfbC dUTP pyruvate DHAP deoA IMP A, O-acetylserine dioxygenase: polynucleotide proline carrier- carrier- [acyl-carrier- [acyl-carrier- carrier- carrier- alpha- acetyl- -D-glucosamine isomerase: pgi glmU galU ATP phosphoribosyltransferase: hpt xanthine and xanthosine salvage pyrimidine ribonucleosides salvage I aldolase sgaE probable UDP- glycerophosphodiester kinase: S1287 a (3R)-3- synthase II: fabF β phosphoribosylaminoimidazolecarboxamide CTP IMP sulfhydrolase A: cysK alcohol putative 6-pyruvoyl putative glutamine synthetase protein] protein] protein] protein] protein] protein] amylase: UDP-3-O-acyl N- D-glucopyranose dTDP- -L- and 2-keto-4- [+ 3 isozymes] purine-nucleoside tauD N-acetyl-D- phosphodiesterase: glpQ phosphorylase: dipeptidase: hydroxyoctanoyl-[acp] UDP-N-acetyl- α formyltransferase, AICAR deoxyuridinetriphosphatase: dut pyruvate 2-deoxy-D-ribose 5-phosphate dehydrogenase: tetrahydrobiopterin hydrogenase adenylyltransferase: putative reductase reductase reductase: reductase: reductase malS acetylglucosamine rhamnose UDP- -D-glucose dADP hydroxyglutarate triosephosphate phosphorylase: dehydrogenase: 2-aminoacetaldehyde mannosaminuronic glycerophosphodiester pnp pepQ reductase an acetoacetyl-[acp] 6-phosphate α-D-glucosamine IMP cytidine dehydrogenase adhP synthase: ygcM subunit: S3245 glnE dihydroxyacetone deacetylase: lpxC formyltransferase; IMP cyclohydrolase: purH aldolase: eda deoD guaB xanthine a cerotoyl-[acp(NADH): fabI (NADH): fabI a cis,cis-fabG a (3R,7Z)-3-fabG (NADH) (NADH) AcpP (3R)- dUMP xanthosine (d: aceF aceE isomerase: tpiA uracil 2-deoxy-α-D- cys acid transferase: phosphodiesterase: ugpQ kinase: S1286 a trans-delta2-cis-cis- hydroxymyristol UDP-3-O-(3- CDP nucleoside 2-deoxyribose-5- XMP wecG [+ 6 isozymes] domain within a delta5,23-3- hydroxytetradec- a trans-delta2-: fabI a trans-delta2-: fabI cytidine/ uridine/ ribose 1-phosphate xanthine:NAD+ a nucleoside a single- delta7-19-C38:3-[acp] glucose maltose hydroxymyristoyl) purine-nucleoside hypoxanthine phosphate aldolase: deoC (6R)-6-pyruvoyl- a [glutamine DHAP a proteinogenic fatty acid synthase] oxo-C42:2-[acp] cis,cis-delta15,27- cis-delta13- acyl carrier IMP thymidylate synthetase: thyA diphosphate deoxycytidine cytidine acetyl-CoA D-glyceraldehyde a reduced stranded RNA pro 7-enoyl-[acp] -α-D-glucosamine ribonucleoside diphosphate phosphopentomutase: oxidoreductase: β α an aldehyde sn-glycerol 5,6,7,8- triphosphate diphosphate synthetase]-O amino acid protein Aromatic Compound Other Biosynthesis kinase: ndk phosphorylase: deoD 3-phosphate -D-ManNAcA-(1->4)- -D- UDP ethanolamine a reduced C46:3-[acp] C32:2-[acp] reductase 1: nrdB nrdA deaminase: cdd kinase: udk S3068 cytochrome c + 4 UDP-3-O-(3- xanthine deoB GlcNAc-PP-undecaprenol L 3-phosphate tetrahydropterin H ferredoxin [iron- -(5'-adenylyl) dehydratase: fabZ Biosynthesis dTMP oxaloacetate glyceraldehyde- acetaldehyde D-glyceraldehyde 3-phosphate hydroxymyristoyl) [+ 4 isozymes] sulfur] cluster -L-tyrosine 8-amino-7- dATP uridine CMP 3-phosphate 2-deoxy-D-ribose urate -glucosamine N- cyclopropane dCDP thymidylate kinase: tmk guanine-hypoxanthine citrate synthase: gltA aldehyde a (2E)-oct-2-enoyl-[acp] 3-(4-hydroxyphenyl) oxononanoate IMP dehydrogenase 5-phosphate acyltransferase: fatty acid (CFA) putative thymidylate phosphoribosyltransferase: gpt uridine/ malate dehydrogenase: aldA xanthosine pyruvate biosynthesis biosynthesis I dehydrogenase: nucleoside superpathway of acetyl-CoA A: gapA xanthine a (3R)-3- a lignoceroyl-[acp a cis,cis-delta7,19- a (5Z)-3- a cis,cis- lpxD + a lipoprotein enoyl-[acyl- biosynthesis guaB kinase: yceG guanosine nucleotides superpathway of 5-aminoimidazole cytidine dehydrogenase: mdhputative enzyme: S0868 2-deoxyribose- [+ 4 isozymes] Alcohol Degradation a primary alcohol a protein with glutathione NADPH NAD + a reduced c- nitrite A NADPH H L-selenocystathionine β-aspartyl dipeptide a cis,cis-delta7,25- a cis-delta17- diphosphate kinase: ndk an oxidized azurin gln + hydroxydocosanoyl- domain within a 3-hydroxyC38:2- oxotetracos- delta15,33- IPP UDP-2-N,3-O-bis[(3R)- a [phospholipid] cis ribonucleotide biosynthesis kinase: udk 2-oxoglutarate NADH H a disulfide bond type cytochrome signal peptide carrier-protein] tyr a malonyl-[acp] dTDP de novo biosynthesis I XMP [+ 39 isozymes] 13-DPG 5-phosphate xanthine:NAD+ purine-nucleoside fatty acid synthase] C44:2-[acp] [acp] 5-enoyl-[acp] C52:2-[acp] C36:1-[acp] protease 3-hydroxytetradecanoyl]- -olefinic fatty acid dCTP malate synthase G: glcB acetyl-CoA [acp] (3R)- enoyl-[acyl- enoyl-[acyl- 3-oxoacyl- 3-oxoacyl- enoyl-[acyl- enoyl-[acyl- LytB reductase cyclopropane tyrosine UMP aldolase: oxidoreductase: phosphorylase: glycerol and glycerophosphodiester degradation IV, a signal α-D-glucosamine (S)-malate citrate glycerol degradation V hydroxymyristol carrier- carrier- [acyl-carrier- [acyl-carrier- (NADH): fabI IMP PRPP deoC S3068 ethylene glycol pyridine nucleotide putative NADPH cystathionine isoaspartyl carrier- carrier- protein: fatty acid elongation -- saturated fatty acyl aminotransferase: nucleoside phosphoglycerate deoD peptide hypothetical aconitate degradation alcohol glutamate oxidized nitrite dehydrogenase: beta-lyase (beta- acyl carrier protein] protein] protein] protein] protein] protein] lytB phospholipid 3-(4- tyrB a malonyl-[acp] XMP diphosphate kinase: ndk amidophosphoribosyltransferase, kinase: pgk purine ribonucleosides degradation transhydrogenase: dipeptidase: peptidase: an octanoyl-[acp] protein: ybbF hydrase B: acnB urate xanthine a glycerophosphodiester dehydrogenase: synthase, small glutaredoxin: reductase, ygjL protein reductase reductase reductase: reductase: reductase reductase (E)-4-hydroxy-3- a [phospholipid]synthase: cfa hydroxyphenyl) methyl ester IMP PRPP amidotransferase: purF fumarase C, fumarate D-glyceraldehyde glycerol pntB pntA cystathionase) iadA sppA 3-phospho- acetaldehyde glycerol ethylene glycol adhP subunit: gltD grxA NirC dehydratase: fabZ (NADH): fabI (NADH): fabI fabG fabG (NADH) (NADH) methylbut-2-en- an acetoacetyl-[acp] fatty acid containing pyruvate dTTP dehydrogenase: 5-phospho-β-D-ribosylamine hydratase Class aconitate 3-phosphate [+ 2 isozymes] : metC a (2E)-tetracos-2-enoyl- a cis,cis- a (3R,5Z)-3- 3-oxoacyl-[acyl- lipid X GMP D-glycerate xanthine:NAD+ L-1,2-propanediol protein: nirC a (2E)-docos- a trans-delta2-cis,cis- : fabI : fabI a peptide 1-yl diphosphate cyclopropane guaB II; isozyme: fumC hydrase 1: acnA aldehyde glycerophosphodiester ethanol [acp domain within delta7,19-3- hydroxytetracos- a trans-delta2- a trans-delta2- synthetase adenosine oxidoreductase: + 2-enoyl-[acp] delta7,25-C44:3-[acp] carrier-protein] phosphoribosylglycinamide dihydroxyacetone oxidoreductase: fucO a protein with A(H2) NADP a proteinogenic a fatty acid synthase] oxo-C38:2-[acp] 5-enoyl-[acp] cis,cis-delta15,33- cis-delta17- (glutamine- [+ 2 isozymes] phosphoglyceromutase dehydrogenase: glycerol phosphodiesterase: ugpQ degradation I asp synthase II: fabF LpxB: lpxB phosphoglyceromutase S3068 an aldehyde GSSG + amino acid synthetase, GAR fumarate cis-aconitate 1: gpmA glycolaldehyde a reduced azurin glu + reduced L- NADH NADP pyruvate seleno-L- C52:3-[acp] C36:2-[acp] a 3-oxoglutaryl- hydrolyzing) XMP 1: gpmA aldA kinase: glycerophosphodiester NAD an oxidized c- 3-oxoacyl-[acyl- synthetase: purD purine-nucleoside putative cysteine residues nitric oxide homocysteine lipid A disaccharide [acp] methyl ester : guaA glyoxylate aconitate phosphoglyceromutase [+ 4 isozymes] adenosine urate glpK phosphodiesterase: glpQ ethanol aldehyde type cytochrome carrier-protein] succinate [+ 2 isozymes] phosphorylase: dihydroxyacetone (E. coli) GMP synthetase GAR hydrase B: acnB 2: gpmB nucleotides alcohol dehydrogenase: aldH synthase I: fabB a 3-oxoacyl-[acp] 3-oxoacyl- glutamine adenine and dehydrogenase, deoD kinase: S1286 (glutamine- aconitate 2-phospho- acetyl-CoA degradation III sn-glycerol dehydrogenase: [+ 3 isozymes] tetraacyldisaccharide [acyl-carrier- amidotransferase asp adenosine salvage V flavoprotein adenosine putative hydrolyzing): guaA phosphoribosylglycinamide hydrase 1: acnA D-glycerate 3-phosphate adhP a (3R)-3- a (6Z)-3- a (1->4)- 4'-kinase: ycaH subunit: sdhA AMP deaminase: add dihydroxyacetone 1 + a dipetide with an N- a 3-oxodecanoyl-[acp] protein] subunit of phosphoribosylglycinamide formyltransferase 2: purT glycolate an oxidized a primary alcohol 2-oxoglutarate N -methyladenine vanillin ammonium NAD H O RX glutathione ATP selenate a cis,cis-delta9,27- DMKH a cis-delta9- α DMAPP isocitrate lyase: aceA AMP [+ 2 isozymes] a tRNA precursor ala 2 hydroxyicosanoyl- terminal L-aspartate thr 2 oxooctadec- an octanoyl-[acp] -D-glucan reductase: heterodimer with glutamine formyltransferase 2: purT enolase: sn-glycerol- kinase: S1287 cytochrome c550 ATP C46:2-[acp] C28:1-[acp] lipid IV (E. coli) adenylosuccinate adenine phosphoribosylglycinamide succinate D-threo-isocitrate acetaldehyde CTP [acp] ubiquinone/ 6-enoyl-[acp] 1,4-alpha- 3-oxoacyl-[acyl- A fabG HisF, imidazole amidotransferase eno nucleosidase: xanthosine adenosine inosine guanosine 3-phosphate (3R)- threonine enoyl-[acyl- 3-oxoacyl- enoyl-[acyl- enoyl-[acyl- LytB synthetase: purA purine-nucleoside formyltransferase 1: purN isocitrate menaquinone glucan carrier-protein] 3-oxoacyl-[acyl- a (3R)-3- subunit of amn dehydrogenase DHAP glutathionine hydroxymyristol dehydratase carrier- [acyl-carrier- carrier- carrier- protein: 3-oxoacyl-[acyl- glycerol phosphate phosphorylase: dehydrogenase: icdA phosphoenol pyrimidine aldehyde alkylated nitrite reductase ATP-sulfurylase branching carrier-protein] cardiolipin and phosphatidylethanolamine biosynthesis (Xanthomonas) succinyl-CoA alcohol putative acyl carrier peptidase protein] biosynthesis protein] reductase: fabG carrier-protein] hydroxyglutaryl- synthase heterodimer with FGAR ribonucleosides (aerobic): glpD dehydrogenase: DNA repair tRNA nucleotidyl (NAD(P)H) S-transferase: (ATP:sulfate operon activator protein] protein] lytB adenylo-succinate deoD pyruvate adenine dehydrogenase: aminotransferase: E: pepE methyltransferase: enzyme: (E)-4-hydroxy-3- synthase I: fabB [acp] methyl ester holoenzyme: hisH HisF, imidazole synthetase: sucC sucD protein: alkB transferase: cca gst adenylyltransferase) protein protein: tdcR reductase reductase: reductase reductase a (3R)-3- reductase: fabG adenosine degradation purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside sn-glycerol- aldA ybdL subunit: nirD ubiE glgB 3-oxoacyl-[acyl- a CDP- glycerol phosphate phosphoribosylformyl- pyruvate adhP dehydratase: fabZ (NADH): fabI fabG (NADH) (NADH) a (1,6)-α-D- methylbut-2-en- hydroxydecanoyl-[acp] cytidine phosphorylase: phosphorylase: phosphorylase: phosphorylase: 3-phosphate [+ 4 isozymes] nitrite reductase, , subunit 1: cysN [+ 2 isozymes] a (3R,6Z)-3- diacylglycerol adenylosuccinate glycineamide synthetase, kinase [+ 2 isozymes] a (2E)-icos- a trans-delta2-cis,cis- MQH 1-yl diphosphate carrier-protein] synthase 2 hydroxyoctadec- : fabI : fabI glucosyl-(1,4) GMP lyase: purB purine-nucleoside cytidine/ deoD deoD deoD deoD dehydrogenase NirC protein: nirC a glutathione- 2-oxobutanoate a trans-delta2- beta- a 2,3,4-saturatedsynthase II: fabF a (3R)-3-hydroxyacyl- holoenzyme: hisH FGAM synthetase: purL succinyl-CoA 2-oxoglutarate phosphoenolpyruvate II: pykA acetyl-CoA formaldehyde HX 2-enoyl-[acp] a proteinogenic delta9,27-C46:3-[acp] a (2E)-oct- -α-glucan a (2E)- phosphorylase: deoxycytidine (anaerobic): succinate a tRNA containing asp 6-enoyl-[acp] cis-delta9- hydroxydecanoyl fatty acyl-[acp] [acyl-carrier protein] cardiolipin phosphatidylserine synthase: ppsA pyruvate an aldehyde a reduced adenine S-conjugate adenosine 5'- amino acid 2-enoyl-[acp] (3R)- enoylglutaryl- AMP deoD FGAM deaminase: cdd glpB glpA glpC a 3' CCA end vanillylamine pyruvate C28:2-[acp] thioester synthase: cls synthase: pssA guanylate kinase α-D-ribose-1-phosphate cytochrome c550 phosphoselenate hydroxymyristol [acp] methyl ester GMP uridine nitrite kinase: gmk adenosine I: pykF dehydrase, trans- acyl carrier enoyl-[acyl- adenylate DHAP phosphatidylserine deaminase: add phosphoribosylaminoimidazole uridine phosphopentomutase: 2-decenoyl-ACP protein Ptd Gro a phosphatidylserine kinase: adk 2-oxoglutarate 2+ 2+ 2 decarboxylase: psd carrier- synthetase, AIR synthetase: purM phosphorylase: Mo ModD Mo isomerase: fabA GDP guanylate dehydrogenase pyruvate deoB dehydratase: fabZ protein] 10 RNase E mRNA 3 1-palmitoyl- UDP-N-acetyl- a phosphatidylethanolamine inosine udp an N - an N -methyladenine a (3R)-3- salicin 6- a (3R,6Z)-3- a cis,cis- a [protein]-L- ADP kinase: gmk (decarboxylase an L-methionyl- an oxidized c- (S)-lactate α L(or D)-O- a cis,cis-delta5,23- a reduced c- a cis-delta13-3- a cis-delta19- butan-1-ol (3R)- reductase AIR Met processing sn-glycerol a palmitoyl-[acp] hydroxyhexacosanoyl- phosphate hydroxyoctadec- -D-glucosamine delta15,33- D-ribose 5-phosphate [initiator tRNA ] formyltetrahydrofolate type cytochrome in DNA phosphoserine type cytochrome oxo-C32:1-[acp] C38:1-[acp] methionine component): sucA uracil substrate 3-phosphate C42:2-[acp] peptide putative hydroxymyristol (NADH) inosine- GDP [acp domain within 6-enoyl-[acp](3R)- enoyl-[acyl- putative 3-oxoacyl- 3-hydroxy enoyl-[acyl- 2-oxoglutarate dehydrogenase 3-phosphoserine methionine aldehyde putative acyl carrier : fabI guanosine a fatty acid synthase](3R)- hydroxymyristol UDP-N-acetyl carrier- cytochrome [acyl-carrier- C52:2-[acp]3-oxoacyl- carrier- enoyl-[acyl- (dihydrolipoyltranssuccinase Carboxylate Degradation 3-methyl- 6-phospho- phosphatase: chloride protein ribonucleoside 10-formyltetrahydrofolate:L- L-lactate 1-acyl-sn-glycerol- hydroxymyristol glucosamine- protein] [acyl-carrier- protein] sulfoxide reductase: chloride chloride a 2,3,4-saturated a trans-2-enoyl- a glutaryl-[acp] kinase: gsk RNase adenine DNA beta- acyl carrier serB protein] C peroxidase: channel dehydratase: fabZ carrier-protein] ribonucleoside diphosphate nucleoside ribonucleoside E2 component): sucB methionyl-tRNA(fMet) dehydrogenase: acyl carrier 2-epimerase: protein] reductase: S1557 fatty acyl-[acp] [acyl-carrier protein] Secondary Metabolite Biosynthesis methyl ester purine deoxyribonucleosides salvage Aromatic Compound Degradation E: rne glycosylase 3-phosphate glucosidase protein reductase yhjA reductase: reductase protein reductase reductase ribonucleoside ribonucleoside- diphosphate diphosphate superpathway of N-acetylneuraminate degradation an oxidized c- msrA nucleoside diphosphate membrane- IMP adenine salvage L-ascorbate degradation N-formyltransferase: fmt lldD acyltransferase: protein dehydratase: fabZ wecB serine (NADH): fabI fabG reductase: (NADH) a protein-L- 1-butanal a (2E)-dec-2-enoyl-[acp] (NADH): fabI diphosphate diphosphate kinase: ndk hexitol fermentation to lactate, formate, ethanol and acetate superpathway of hexuronide I: tag A: bglA a (2E,6Z)- a cis-delta13-3- diphosphate reductase 1, 2: nrdF nrdE reductase plsC a (2E)-hexacos-2-enoyl-dehydratase: fabZ a trans-delta2-cis,cis- type cytochrome a cis,cis-fabG : fabI enterobactin biosynthesis bound ATP reductase 1, reductase 3-phenylpropanoate and 3-(3- and hexuronate degradation I (bacterial, anaerobic) octadecadienoyl- hydroxyC32:1- a trans-delta2- methionine- phe PheP phe myo-inositol vibriobactin biosynthesis autoinducer AI-2 biosynthesis I kinase: ndk alpha subunit, 2: nrdF nrdE N-acetylneuraminate RNase E [acp domain within α delta5,23-C42:3-[acp] delta15,33-3- ribonucleoside synthase: an N-formyl- [acp] N-acetyl- -D- UDP [acp] cis-delta19- (S)-S-oxide enoyl-[acyl- biosynthesis B1: nrdA alpha subunit, 2, alpha 2'-deoxyguanosine 2'-deoxyadenosine hydroxyphenyl)propanoate D-sorbitol 6-phosphate L-ascorbate a reduced c- an mRNA fragment processing an apurinic site a fatty acid synthase] β-D-glucose enoyl-[acyl- diphosphate atpI ribonucleoside adenine a β-D-glucuronoside L-methionyl- a tetrahydrofolate pyruvate 3-methyladenine salicyl alcohol mannosamine oxo-C52:2-[acp] carrier-protein] chorismate a 3-oxopimeloyl- B1: nrdA subunit: nrdE GTP degradation to 2-hydroxypentadienoate N-acetylneuraminate 6-phosphate type cytochrome dipalmitoyl 6-phosphate C38:2-[acp] [+ 2 isozymes] reductase diphosphate [initiator tRNA met ] product mRNA within DNA reductase carrier-protein] D-glucopyranose chorismate [acp] methyl ester [+ 10 isozymes] lyase (aldolase) phosphatidate SAM 1: nrdB nrdA [+ 2 isozymes] [+ 2 isozymes] reductase 3-phenylpropanoate beta-D- reductase 6-phosphate isochorismate : nanA glucitol (sorbitol) (NADH): fabI biotin-carboxyl carrier isochorismate pyrimidine deoxyribonucleotide 1: nrdB nrdA 3-dehydro- (NADH): fabI hydroxymutase 3-oxoacyl- adenine probable adenine -6-phosphate glucuronidase: protein assembly hydroxymutase phosphorylation dGMP dAMP L-gulonate [acyl-carrier- phosphoribosyltransferase: apt deaminase (synthesis N-acetyl-D-mannosamine uidA a peptide with a (3R)-3- arbutin 6- a UDP-sugar an oxidized a cis-delta21-39- a cis,cis- a non-methylated a protein-L- a decanoyl-[acyl-carrier protein] 2: menF phenylpropionate dehydrogenase: 6-phosphate a reduced ferredoxin H O [DNA] a cis-delta17-3- D-carnitine a [biotin 2: menF protein] dTMP dCMP diphosphate 2 an N-terminal nitroaromatic methionine- Ins(3)P SAH xanthine): yicP srlD 2-oxoglutarate gln H + DL-allothreonine a PII protein hydroxytetracosanoyl- phosphate dATP oxo-40-methyl- delta11,29- ribosomal carboxyl-carrier dioxygenase: D-glucopyranuronate probable [iron-sulfur] cluster compound oxo-C36:1-[acp] (R)-S-oxide isochorismate reductase: GTP thymidylate cytidylate dGDP guanylate UTP Xaa-L-proline [acp domain within DNA oxygen- C59:1-[acp]cyclopropane 3-oxoacyl- 3-hydroxy protein L11 carnitine 3-oxoacyl-[acyl- isochorismate AMP hcaA2 hcaA1 3-(3- putative sorbitol- hexulose-6- UDP-sugar methylase peptide protein]-L-lysine Inositol-1- fabG dGDP ATP kinase: tmk kinase: cmk kinase: gmk a fatty acid synthase](3R)- polymerase C48:2-[acp]3-oxoacyl- carrier-protein] S-adenosylhomocysteine dADP hydroxyphenyl) 6-phosphate 2- 6-phospho- dATP insensitive fatty acyl [acyl-carrier- for 50S methionine racemase: biotin- monophosphatase: 2,3-dihydro-2,3- a (3R)-3- dCDP ferredoxin, 3- phosphate inorganic hydrolase (5- III, epsilon [acyl-carrier- synthase II: fabF 2,3-dihydro-2,3- nucleosidase: pfs putative nucleoside hypoxanthine propanoate N-acetyl-D-mannosamine dehydrogenase: proline hydroxymyristol pyrophosphohydrolase: NAD(P)H phospholipid protein] ribosomal sulfoxide caiD [acetyl CoA suhB dihydroxybenzoate hydroxypimeloyl- phenylpropionate synthase: glutamate synthase, serine pyrophosphatase: PII-uridylyltransferase: beta- nucleotidase) dihydroxybenzoate thymidylate nucleoside diphosphate aminopeptidase acyl carrier ntpA a 2'- subunit: dnaQ nitroreductase: synthase: cfa reductase: protein] reductase: 3-oxoacyl-[acyl- synthetase, [acp] methyl ester anaerobic anaerobic dGDP dADP dioxygenase 6-phosphate sorD sgaH small subunit: gltD hydroxymethyltransferase: glyA glnD glucosidase : ushA subunit L-carnitine carboxylase] synthetase, kinase: yceG diphosphate kinase: ndk aldehydo-D- ppa P II: pepP protein a cis-keto-C60- fabG reductase: carrier-protein] myo-inositol S-ribosyl-L-homocysteine ribonucleoside- nucleoside ribonucleoside- nucleoside guanine-hypoxanthine system: hcaA2 aldehydo-D-glucuronate A: bglA deoxyribonucleoside a hydroxylaminonfnB a cis-delta17-3- protein msrA holoenzyme isochroismatase: entB dTDP galacturonate L-xylulose a (2E)-tetracos-2-enoyl-dehydratase: fabZ dAMP meroacyl-[acp] a cis,cis-fabG a [protein]-L- synthase I: fabB isochroismatase: entB triphosphate diphosphate triphosphate diphosphate kinase: ndk nucleoside nucleoside phosphoribosyltransferase: gpt keto-D-fructose 5'-monophosphate group-containing hydroxyC36:1- L11: prmA synthetase (2S,3S)-2,3-dihydroxy- hcaA1 hcaC D-mannitol 1-phosphate uronate uronate 5-phosphate an α-D-aldose a methylated (2S,3S)-2,3-dihydroxy- reductase: nrdD kinase: ndk reductase: nrdD kinase: ndk dGTP [acp domain within UMP delta11,29-3- methionine S-ribosylhomocysteine nucleoside dCTP diphosphate diphosphate hypoxanthine 6-phosphate an oxidized ferredoxin + a uridylylated a peptide with β compound [acp] ribosomal and biotin 2,3-dihydrobenzoate a (2E)- N-acetyl-D-glucosamine isomerase: isomerase: putative glu acetaldehyde gly phosphate H a proteinogenic a fatty acid synthase] -D-glucose 1-phosphate oxo-C48:2-[acp] a 3-oxododecanoyl-[acp] 2,3-dihydrobenzoate diphosphate kinase: ndk kinase: ndk phosphoribosyltransferase: hpt 3-(5,6- [iron-sulfur] cluster PII protein an N-terminal hydroquinone protein L11 operon 2,3-dihydro-2,3- lyase: ygaG enoylpimeloyl- uxaC uxaC hexulose-6- amino acid 6-phosphate 2,3-dihydro-2,3- kinase: ndk dihydroxycyclohexa- 6-phosphate mannitol-1- L-proline repressor: birA dihydroxybenzoate [acp] methyl ester phosphate 3-oxoacyl-[acyl- dihydroxybenzoate AI-2 dGTP dATP dGTP dATP IMP 1,3-dien-1-yl) N-acetylglucosamine- phosphate D-tagaturonate D-fructuronate a [biotin carboxyl- dehydrogenase: entA ser enoyl-[acyl- dTTP isomerase: carrier-protein] [EntB aryl- dehydrogenase: entA propanoate 6-phosphate dehydrogenase: carrier protein]-N [EntF L-seryl- 34 a (1,6)-α-D- a (1->4)- 1915 a cis,cis- a glucosylated reductase: fabG carrier- altronate D-mannonate sgaU a guanine a 2-oxo a pseudouridine D-gluconate a phosphate 6 carrier protein] deacetylase: agaA mtlD a 5-L-glutamyl- queuine pimeloyl-CoA maltotetraose 2-methylbutanol isobutanol ATP -biotinyl-L-lysine 2,3-dihydroxybenzoate enterochelin carrier protein] an amino acid met ala glucosyl-(1,4) ser glyoxylate α-D-glucan 6-phosphate delta21,39-3- glycogenin 2,3-dihydroxybenzoate aerobactin biosynthesis protein] oxidoreductase: oxidoreductase: L-ribulose 5- in tRNA carboxylate in 23S rRNA monoester dGTP a (3R)-3- CoA:apo-[acyl-carrier-protein] synthetase, 2,3-dihydroxy-2,3- N-acetylglucosamine- [peptide] -α-glucan alcohol alcohol gluconate-6- hydroxyC58:2- 1,4-alpha- 2,3- reductase dihydrophenylpropionate uxaB uxuB phosphate putative adenylate hydroxydodecanoyl-[acp] pantetheinephosphotransferase: component 2,3- (2R,4S)-2-methyl-2,4- 6-phosphate alpha- dehydrogenase: hypothetical dehydrogenase: phosphate [acp] 3-oxoacyl- 7,8-dihydro-8- glucan dihydroxybenzoate- (NADH) dehydrogenase: hcaB maltodextrin alkaline cyclase: acpS D: entD dihydroxybenzoate- dihydroxydihydrofuran-3-one deacetylase: nagA F6P D-altronate D-mannonate putative tRNA-guanine tyrosine adhP protein: ybeA adhP dehydrogenase: oxoguanine- branching (3R)- a [biotin carboxyl- AMP ligase: entE lys : fabI 8-amino-7- alpha- glucosidase: amylase: phosphatase [acyl-carrier- cyaA epimerase/ gamma- aminotransferase: hypothetical 3 gnd triphosphatase: enzyme: hydroxymyristol carrier-protein a holo-[EntB aryl- a holo-[EntF L- AMP ligase: entE lysine:N6- transglycosylase: tgt oxononanoate amylase: malZ malS putative aldehyde an N - putative aldehyde 2-dehydro- I: yhbX protein] (2,3-dihydroxybenzoyl) a pimeloyl-[acp] D-glucosamine 6-phosphate aldolase: glutamyltranspeptidase: ggt protein: sgaT 1915 6 (L-seryl)adenylate 6-phosphofructokinase tyrB methylpseudouridine mutT glgB cyclic-AMP acyl carrier dimer]-N - carrier protein] seryl-carrier protein] hydroxylase: 2,3-DHP altronate synthase: bioF malS reductase: S1557 reductase: S1557 6-phospho- [+ 2 isozymes] reductase: adenylate (2,3-dihydroxybenzoyl)adenylate methyl ester fructose- II: pfkB altronate sgaE in 23S rRNA a glycogen protein biotinyl-L-lysine 6 iucD hydrolase: 2-methylbutanal isobutanal a cis,cis-fabG dGMP (2R,4S)-2-methyl-2,3,3,4- N -hydroxy- Amine and Polyamine Biosynthesis a queuosine 34 a (1->4)- D-gluconate an alcohol dehydratase: fabZ bisphosphatase: fbp 6-phosphofructokinase hydrolase: L-ribulose-5- an α-(5-L- 4-(methylsulfanyl) D-glucopyranose maltotriose maltohexaose delta21,39-3- BCCP- acetyl CoA dihydroxybenzoate- dihydroxybenzoate- tetrahydroxytetrahydrofuran L-lysine uxaA a proteinogenic (8S)-8-amino-7- a (1,6)-α-D- a malto- α-D-glucan I: pfkA uxaA phosphate 4- glutamyl)- guanine in tRNA -2-oxobutanoate coenzyme A hydroxypyruvate oxo-C58:2-[acp] carboxylase, mannonate a peptide amino acid glucosyl-(1,4) oligosaccharide gly biotin: AMP ligase: AMP ligase: 6 epimerase: oxononanoate a (2E)-dodec-2-enoyl-[acp] biotin N -hydroxylysine O spermidine biosynthesis I (2Z,4E)-2- α-D-glucosamine 6-phosphate β-D-fructose 1,6- amino acid -α-glucan accB entD entE entB entD entE entB putrescine putrescine hydrolase: carboxylase -acetyltransferase: hydroxy-6- bisphosphate araD a 2,3-dihydroxybenzoyl-[VibB] a pimeloyl-[acp] biosynthesis I biosynthesis III glucosamine- uxuA enoyl-[acyl- [+ 2 isozymes] subunit: accC iucB oxonona-2,4- D-xylulose a 2,3-dihydroxybenzoyl- SAM 6-phosphate a ring-opened 7- an O 6 - a (1->4)- a [protein] N- a [lipoyl-carrier a cis,cis- carrier-protein] a [carboxyl-carrier a seryl-[EntF L- 6 6 diene-1,9-dioate 5-phosphate a [protein]- 2-deoxy-D- α thymidine [EntB aryl- N -acetyl-N - 8-amino-7- RNA butanoyl-CoA acetoacetate 2-phenylethanol 3-methylbutanol 6 an adenine in DNA -amylose 6 L-ornithine deaminase: nagB methylguanine methylguanine 2,3- ser α-D-glucan terminal-formyl- 13-DPG protein]-N -[(R) delta19,31-3- ser reductase protein dimer]-N seryl-carrier protein] hydroxy-L-lysine arg putative L-cysteine gluconate carrier protein] oxononanoate in DNA in DNA dihydroxybenzoate L-methionine alcohol alcohol -dihydrolipoyl]- 2-deoxy-D- putative hydroxyC50:2- 1,4-alpha- thymidine (NADH): fabI -carboxybiotinyl- biosynthetic ornithine epimerase/ glyceraldehyde- L-serine synthase: bioF S-adenosylmethionine F6P dehydrogenase: dehydrogenase: L-lysine gluconate 3- adenine- glucan kinase: tdk L-lysine decarboxylase maltodextrin 3-phosphate lipoamide [acp] 3-oxoacyl- dihydroxybenzoate- decarboxylase: speD arginine aldolase: sgaE 2-dehydro-3- RNase putative adhP adhP dehydratase branching a dodecanoyl-[acp] norspermidine-2,3- (8S)-8-amino-7- (2Z)-2- O-6-alkylguanine- dihydroxybenzoate- peptide dehydrogenase dehydrogenase: specific [acyl-carrier- cis-vaccenate biosynthesis AMP ligase: a dihydroxyphenyl-5- decarboxylase: isozyme: speC 6-phosphofructokinase [+ 3 isozymes] deoxy-D-gluconate formamidopyrimidine D: rnd coat glucosidase: dehydrogenase (deaminase) dTMP 1 oxononanoate kduD methylase: enzyme: dihydroxybenzoate N -citryl-N putrescine hydroxypenta- succinate DNA/cysteine-protein AMP ligase: malZ deformylase: putative aldehyde putative aldehyde A: gapA (NADH): lpdA 3-dehydro- protein] entD entE entB methyloxazoline-[VibF] speA fructose- II: pfkB DNA glycosylase: mutM [+ 6 isozymes] protein: D-glyceraldehyde a [lipoyl-carrier , L-SD2: sdaB glgB 6 -acetyl-N 6 - dAdoMet 2,4-dienoate triosephosphate ketodeoxygluconokinase: methyltransferase: ogt entD entE entB def reductase: S1557 reductase: S1557 yfcB reductase: S0240 6 2-deoxy-D- 6 β a palmitoleoyl-[acp] biodegradative bisphosphatase: fbp 6-phosphofructokinase 3-phosphate protein]-N -[(R an N -methyladenine [+ 2 isozymes] -ketomeristoyl- an N-(2,3- hydroxy-L-lysine D-glyceraldehyde isomerase: tpiA kdgK a (1->4)- phenylacetaldehyde 3-methylbutanal gluconate a cis,cis-fabG amylopectin 3-oxoacyl-[acyl- arginine I: pfkA DHAP an [RNA]-3'- a 5'-hydroxy- D-glucopyranose )-lipoyl]-L-lysine in DNA pyruvate [acp] dihydroxybenzoyl)- putrescine 3-phosphate a [DNA]- a 5'-phospho- 2,6-diamino-4- α-D-glucan delta19,31-3- carrier-protein] decarboxylase: 4-oxo-2-pentenal a [protein]-S- ribonucleoside- ribonucleotide- an N-terminal L- synthase: fabH β KDGP nucleotide- [DNA] hydroxy-5-(N-methyl) a guanine in DNA enterobactin formate oxo-C50:2-[acp] seryl-[EntF L-seryl- dihydroxyphenyl-5- adiA -D-fructose 1,6-bisphosphate glyceraldehyde- methyl-L-cysteine 3'-phosphate 3'-[RNA] acetoacetyl-CoA butanoate methionyl-[protein] [+ 2 isozymes] laurate synthase I: fabB 3'-phosphate formamidopyrimidine an (11Z)-3-oxooctadec- carrier protein] methyloxazoline-norspermidine- spermidine agmatine 3-phosphate 11-enoyl-[acp] aerobactin synthase, putrescine acyl-CoA 2,3-dihydro-2,3- 2,3-dihydroxybenzoate dehydrogenase 2-keto-3- synthetase, long- 3-oxoacyl-[acyl- dihydroxybenzoate aminopropyltransferase: agmatinase: A: gapA a 2-oxo a peptide with a cis-delta19- (E)-4-hydroxy-3- a cis,cis- a 3-oxotetradecanoyl-[acp] putative deoxygluconate a maltooligosyl-trehalose O-succinyl-L- a O- D-tagatofuranose chain-fatty-acid-- synthetase, speE speB PLP L-ornithine octanoate itaconate 4-tyrosol apo-4'-lycopenal methylbut-2-en- a protein carrier-protein] epimerase/ 6-phosphate D-ala carboxylate an N-terminal homoserine 37-methoxy-38- a protein delta15,27-3- isochroismatase: entB alcohol sialoglycoprotein aldehyde 1-yl diphosphate putative 3-oxoacyl-[acyl- CoA ligase: fadD reductase: fabG S-methyl-5'- aldolase: sgaE 13-DPG aldolase Xaa-L-proline putative O- methyl-C57:1-[acp]cyclopropane hydroxyC46:2- putative vibriobactin spermidine putrescine dehydrogenase: dehydrogenase: putative serine 3-oxoacyl- tagatose 6- carrier-protein] thioadenosine [+ 3 isozymes] and 2-keto-4- sialoglycoprotein fatty acyl hypothetical [acp] membrane lauroyl-CoA a (3R,11Z)-3-hydroxyoctadec- enterobactin probable ornithine acyl-CoA synthetase, succinyl-CoA adhP aldA protease: S1990 phosphate reductase: fabG phosphoglycerate hydroxyglutarate serine alpha- cystathionine endopeptidase: phospholipid protein: gcpE [acyl-carrier- pump 11-enoyl-[acp] aminotransferase: long-chain-fatty-acid- synthetase, alpha aminopeptidase [+ 2 isozymes] kinase triosephosphate kinase: pgk aldolase: eda hydroxymethyltransferase: glyA amylase: malS gamma- putative aldehyde ygjD [+ 3 isozymes] synthase: cfa 2-C-methyl-D- protein] protein: ybhI a (3R)-3- (3R)-hydroxymyristol ygjG -CoA ligase: fadD subunit: sucD A/I: pepA apo-4'- 2: agaZ isomerase: tpiA alanine racemase 2: dadX synthase: metB reductase: S1557 a cis-methoxy- erythritol-2,4- a peptide reductase: hydroxytetradecanoyl-[acp] acyl carrier protein D-glyceraldehyde 3-phosphate DHAP (4-hydroxyphenyl) a peptide lycopenoate D-tagatofuranose a peptide superpathway of phospholipid biosynthesis I (bacteria) 3-phospho-D-glycerate C59-meroacyl-[acp] cyclodiphosphate a cis,cis-fabG D-glyceraldehyde acetaldehyde 6-phosphate (3R)- dehydratase: fabZ Amino Acid Biosynthesis pyruvate a peptide with a maltodextrin α,α-trehalose delta15,27-3- superpathway of L- superpathway of aromatic amino acid biosynthesis superpathway of L-lysine, L-threonine and L-methionine biosynthesis I glyceraldehyde- 3-phosphate a proteinogenic L-glutamate-5- AMP octanoyl-CoA itaconyl-CoA GDP superpathway of L- superpathway of L- superpathway of L- L-histidine biosynthesis superpathway of branched chain amino acid biosynthesis superpathway of L-homoserine L-arginine biosynthesis IV (archaea) phosphoglyceromutase pyruvate diphosphate phosphate a proteinogenic 2-oxobutanoate succinate oxo-C46:2-[acp] hydroxymyristol DHAP a (2E,11Z)-octadeca- tryptophan biosynthesis 3-phosphate phosphoglyceromutase pyridoxamine 5'-phosphate amino acid semialdehyde an N-terminal isoleucine biosynthesis I phenylalanine biosynthesis tyrosine biosynthesis and L-methionine biosynthesis 1: gpmA amino acid acyl carrier 2,11-dienoyl-[acp] D-erythrose dehydrogenase 1: gpmA L-proline D-erythrose oxaloacetate phosphoglyceromutase protein glycerol-3-phosphate phosphoenolpyruvate D-erythrose phosphoenol D-erythrose phosphoenol PRPP pyruvate A: gapA [+ 2 isozymes] enoyl-[acyl-carrier- 4-phosphate 4-phosphate oxaloacetate thr glu 2: gpmB dehydratase: fabZ dehydrogenase 4-phosphate pyruvate 4-phosphate pyruvate asp protein] reductase aspartate aspartate acetyl-CoA fermentation to butanoate II a dimer of non- 4-(γ-L-glutamylamino) 2-hydroxy-5- a 3- a negatively a [protein]- a [protein]- a cis,cis- (4S,5S)-4,5- (NAD+): gpsA 3-deoxy-D- ATP acetolactate ν pyruvate 4-aminobutanoate succinate (2E,6E)-farnesyl a (2E,9Z)-hexadeca- (NADH): fabI threonine 13-DPG h adjacent 2'- protoheme butanoate carboxymethylmuconate asp O-ureido-L- L-tyrosine L-tyrosine a protein delta13,25-3- dihydroxy-2,6- a collagen a (2E)-tetradec-2-enoyl-[acp] 3-deoxy-D- arabinoheptulosonate- aminotransferase: phosphoribosyltransferase: aminotransferase: synthase aspartokinase II 2-phospho-D-glycerate diphosphate demethyubiquinol 2,9-dienoyl-[acp] supercoiled DNA 3-deoxy-D- 3-deoxy-D- aspC deaminase deoxycytidine and semialdehyde homoserine ubiquinone/ putative DNA putative phosphate hydroxyC44:2- dioxohexanoate sn-glycerol 3-phosphate arabinoheptulosonate- 7-phosphate aspC hisG I, valine- and homoserine acetyl-CoA 5-carboxy-2- enoyl-[acyl- probable putative a cis-vaccenoyl-[acp] arabinoheptulosonate- arabinoheptulosonate- (dehydratase) phosphoglycerate thymidine in DNA menaquinone topoisomerase: oxidoreductase, putative serine [acp] putative enoyl-[acyl- 7-phosphate synthase (DAHP sensitive, dehydrogenase II: metL enolase: eno probable hydroxymuconate carrier-protein] protein-tyrosine- 3-oxoacyl- aldose asp an [amino-group GABA succinyl-CoA protoheme IX Fe-S subunit: yffG protease: S1990 collagenase: 7-phosphate 7-phosphate 1-(5-phospho-β-D-ribosyl)-ATP asp : ilvA kinase: pgk biosynthesis reductase yrdD [acyl-carrier- reductase: carrier-protein] synthase (DAHP synthetase, tyrosine large [+ 2 isozymes] carrier protein]- transaminase: synthetase, alpha amidotransferase semialdehyde argininosuccinate phosphatase: [+ 2 isozymes] yhbU glycerol-3-phosphate glycerol-3-phosphate synthase (DAHP synthase (DAHP [+ 2 isozymes] thiolase I, phosphotransacetylase: pta deoxyribodipyrimidine farnesyltransferase: methyltransferase: [+ 3 isozymes] [+ 5 isozymes] protein] yafB reductase synthetase, tyrosine repressible): aroF aspartokinase II subunit: ilvB C-terminal-γ-(L- gabT subunit: sucD subunit: ycjL dehydrogenase: synthetase: argG (NADH): fabI a [protein]- wzb 2-dehydro- synthetase, tyrosine synthetase, tyrosine phosphoribosyl-amp aspartokinase II 3-phospho-D-glycerate 3-ketoacyl- photolyase cyoE ubiE a relaxed DNA a [protein]- reductase: (NADH): fabI acyltransferase: plsB acyltransferase: plsB repressible): aroF and homoserine (2Z)-2-aminobut- glutamyl)-L-glutamate hpaE a palmitoleoyl-[acp] L-tyrosine a peptide 3-deoxy-D- a peptide [+ 2 isozymes] repressible): aroF repressible): aroF cyclohydrolase; [+ 4 isozymes] L-aspartyl-4-phosphate (photoreactivation): phrB L-tyrosine 3-deoxy-D-arabino- and homoserine 2-enoate CoA thiolase, 5-carboxymethyl-2- UQH phosphate a cis,cis-fabG gluconate [+ 2 isozymes] dehydrogenase phosphoglyceromutase 2 cis-vaccenate phosphoribosyl-ATP dehydrogenase acetylglutamate phosphoglyceromutase phosphoenolpyruvate acetyl-CoA acetyl phosphate succinate hydroxymuconate delta13,25-3- a myristoyl-[acp] heptulosonate II: metL [+ 2 isozymes] [+ 2 isozymes] (S)-2-acetolactate GDP succinyl-CoA 4-aminobutanoate a 2-lysophosphatidate a 2-lysophosphatidate pyrophosphatase: hisI kinase: argB 1: gpmA a 2'-deoxycytidine ala semialdehyde phosphate ferroheme o glu canavaninosuccinate 3-deoxy-D-arabino- 7-phosphate II: metL aspartate-semialdehyde 1: gpmA transferase: a thymidine in DNA oxo-C44:2-[acp] [+ 2 isozymes] 3-deoxy- 3-deoxy- ketol-acid an [amino-group carrier phosphoglyceromutase pyruvate putative in DNA 3-oxoacyl-[acyl- heptulosonate β [+ 2 isozymes] dehydrogenase: asd [+ 2 isozymes] fadA 3-dehydroquinate D-arabino- D-arabino- 1-(5-phospho- -D-ribosyl)-AMP reductoisomerase: protein]-C-terminal- 2: gpmB phosphoenolpyruvate kinase II: pykA kinase: carrier-protein] 1-acyl-sn-glycerol- 1-acyl-sn-glycerol- 7-phosphate L-aspartyl- 2-iminobutanoate synthase: aroB heptulosonate heptulosonate L-aspartyl- ilvC γ-(5-phospho-L- synthase: ppsA pyruvate tdcD glycolate and reductase: fabG 3-phosphate 3-phosphate 3-dehydroquinate 4-phosphate phosphoribosyl-amp L-aspartate 4-semialdehyde 2-phospho-D-glycerate a glutathione- a DNA containing hydrogen 1-chloro-2,4- a cis,cis- 7-phosphate 7-phosphate 4-phosphate (2R)-2,3- glutamyl)-L-glutamate acetoacetyl-CoA glyoxylate a 5-methyltetrahydrofolate a [Co(I) corrinoid NAD(P)H H + a reduced (-)-dehydrodiconiferyl acid glutathione a ribonucleoside salicylaldehyde a [2-Cys peroxiredoxin] an oligopeptide enterobactin acyltransferase: plsC acyltransferase: plsC cyclohydrolase; kinase I: pykF acetate a plastoquinone an apurinic/ ethylphosphate delta17,29-3- a protein D-serine [+ 2 isozymes] phosphatidate biosynthesis (yeast) synthase: aroB 3-dehydroquinate aspartate- N-acetyl-gamma- degradation I Fe-S protein] S-conjugate peroxide thioredoxin dinitrobenzene triphosphate 3-dehydroquinate 3-dehydroquinate dihydroxy-3- aspartokinase II kinase: alcohol aldehyde with a disulfide bond phosphoribosyl-ATP aspartate- glutamylphosphate apyrimidinic site diadenosine anaerobic hydroxyC48:2- D-serine semialdehyde synthase: aroB methylbutanoate enolase: eno pyruvate ackA dehydrogenase: thiol oligopeptidase enterochelin protease: a 3-oxohexadecanoyl-[acp] 3-dehydroquinate 3-dehydroquinate synthase: aroB pyrophosphatase: hisI semialdehyde and homoserine glycolate tetraphosphatase: ribonucleoside- dehydrogenase: [acp] 3-oxoacyl- dehydrogenase: dihydroxyacid reductase: argC putative NADPH glutathionine peroxidase: A: prlC degS dehydratase DHAP dehydratase: aroD 1-(5-phospho-β-D-ribosyl)- dehydrogenase: 2-oxobutanoate dehydrogenase II: metL an [amino-group carrier putative gamma- thiol adhP triphosphate aldH esterase: fes [acyl-carrier- asd (3R)-3- acetate dehydrogenase: endonuclease S-transferase: aphA (deaminase) 3-oxoacyl-[acyl- 3-dehydroquinate 3-dehydroquinate 3-dehydroquinate 5-[(5-phosphoribosylamino) dehydratase: L-lactate methyltransferase: glutamyltranspeptidase: ggt peroxidase: putative aldehyde tpx N-(2,3- [+ 7 isozymes] asd aspartokinase protein]-C-terminal- putative hydroxybutanoyl- ygjL gst [+ 3 isozymes] a 2'- reductase: nrdD [+ 3 isozymes] a [2-Cys peroxiredoxin] protein] : dsdA carrier-protein] dehydratase: aroD L-aspartate 4- acetolactate ilvD γ dehydrogenase: yhdJ III: nth tpx a phosphatidate glycerol-3- 3-dehydroshikimate methylideneamino]imidazole- I, homoserine -(L-glutamate pyruvate glyoxylate reductase: S1557 deoxyribonucleoside salicylate a peptide dihydroxybenzoyl) reductase: reductase: fabG 3-dehydroquinate 3-dehydroquinate L-aspartate 4- CoA (-)-dehydrodiconiferyl ethanol with reduced L- a peptide pyruvate semialdehyde 4-carboxamide synthase 3-methyl-2- dehydrogenase I: thrA 5-semialdehyde- phosphoenolpyruvate lldD formate-lyase -L-serine a cis,cis-fabG phosphate 3-dehydroshikimate dehydratase: aroD dehydratase: aroD semialdehyde an (L- 5'-triphosphate cysteine residues a (3R)-3- putative phosphatidate dehydroshikimate N-(5-phospho-L-ribosyl- III, large oxobutanoate 2-yl)-L-glutamate glyoxylate a [methyl-Co(III) acid aldehyde 2,4-dinitrophenyl- delta17,29-3- dehydrogenase 1-oleoyl-2- aspartokinase II 2 activating a tetrahydrofolate cysteinylglycine) glu a plastoquinol NAD(P) + a 3'-terminal a 5'-phospho- an oxidized H O reductase: aroE subunit: ilvI L-homoserine pyruvate carboligase: corrinoid 2 S-glutathione hydroxyhexadecanoyl-[acp] cytidiltransferase: S1465 (NAD+): gpsA lyso-glycerone and homoserine 3-dehydroshikimate 3-dehydroshikimate formimino)-5-amino-1- hydrogencarbonate enzyme: ybiY D-glucarate -S-conjugate unsaturated sugar [DNA] thioredoxin oxo-C48:2-[acp] dehydroshikimate putative dihydrodipicolinate 2-isopropylmalate branched-chain (S)-lactate gcl Fe-S protein] CDP-diglyceride phosphate dehydrogenase (5- phosphoribosyl)-4- aspartokinase II [+ 2 isozymes] phosphoenolpyruvate kinase II: pykA degradation I (3R)- reductase: aroE oxidoreductase: [+ 5 isozymes] crotonyl-CoA synthetase: cdsA dehydroshikimate dehydroshikimate imidazolecarboxamide synthase: dapA and homoserine (S)-2-aceto-2- synthase: leuA amino-acid homoserine carbamoyl- synthase: ppsA pyruvate tartronate hydroxymyristol sn-glycerol putative II: metL an [amino-group carrier ydiB dehydrogenase aminotransferase: semialdehyde α reductase: aroE reductase: aroE isomerase: hisA hydroxybutanoate transsuccinylase: metA phosphate γ kinase I: pykF putative acyl-CoA D-glucarate dTDP-4-acetamido-4,6- β-D-ManNAcA-(1->4)-α-D- an -D- peptidoglycan D- D-ribofuranose a DNA containing 1402 acyl carrier a CDP-diacylglycerol 3-phosphate oxidoreductase: aspartokinase (2S,4S)-4- protein]-C-terminal- - (5Z,8Z,11Z,14Z,17Z) a cytidine a cis-delta15-3- a (1->4)-β-D-xylan II: metL (2S)-2- ilvE synthase, dehydrogenase: dideoxy-α-D-galactose galactoside hydroxypyruvate (indol-3-yl)glycol histidinol an apurinic/ (+)-muconolactone acetaldehyde an oligopeptide protein ydiB shikimate I, homoserine putative putative phosphoribulosylformimino- hydroxy-2,3,4,5- ketol-acid (L-ornithyl)-L-glutamate acetyl-CoA formate putative GlcNAc-PP-undecaprenol -icosapentaenoyl-CoA gly alanyl-DAP crosslink 5-phosphate uracil in 16S rRNA a protein isopropylmalate arginine pyruvate alcohol apyrimidinic site aldehyde oxo-C34:1-[acp] dehydratase: fabZ dehydrogenase oxidoreductase: oxidoreductase: AICAR-phosphate tetrahydrodipicolinate aspartokinase reductoisomerase: cys O-succinyl-L-homoserine yafH glucarate oxidoreductase for L- endonuclease V putative protease: 3-oxoacyl- putative glycerol-3- hypothetical protease: phosphatidylglycerophosphate phosphatidylserine shikimate shikimate ydiB ydiB I, homoserine ilvC isopropylmalate specific: dehydratase: TDP-Fuc4NAc:lipidII dehydrogenase: histidinal:NAD+ and L- muconate dehydrogenase: degS xylanase: phosphate I: thrA val aldehyde butanoyl-CoA alpha- acyl-CoA murein DD- (deoxyinosine 3 [acyl-carrier- degS synthetase, CDP-1,2-diacyl- synthase: pssA kinase I: aroK dehydrogenase isomerase: carB carA phosphotransacetylase: pta ygcY D-glycerate transferase: wecF adhP pseudouridylate cycloisomerase aldH protein: yraL yieL a (2E)-hexadec-2-enoyl-[acp] acyltransferase: (R)-2,3-dihydroxy- putative pyruvate galactosidase: thioesterase hypothetical endopeptidase: histidinol:NAD+: hisD endonuclease) [+ 4 isozymes] protein] shikimate shikimate shikimate imidazole glycerol leuC leuD dehydrogenase: synthase I: truA I: ycjG a 2'-O- [+ 3 isozymes] a (1->4)- sn-glycero-3-phosphate shikimate L-homoserine I: thrA 3-methylpentanoate homoserine formate-lyase putative 4-alpha-l- melA protein: sgaT putative aldehyde a 2'- : nfi [+ 3 isozymes] reductase: plsB kinase I: aroK phosphate L-ornithine aldA glycerate II: tesB mepA 1402 phosphatidyl transferase: pgsA (S)-2,3,4,5- isopropylmalate transsuccinylase: metA carbamoyl phosphate reductase: S1557 his a peptide methylcytidine β-D-xylan enoyl-[acyl- a phosphatidylserine kinase II: aroL shikimate shikimate dihydroxyacid 2 activating acetyl phosphate glucarate fucosyltransferase: yifM deoxyribonucleoside cis,cis-muconate acetate a cis-delta15-3-fabG a peptide shikimate synthase subunit tetrahydrodipicolinate isomerase [+ 4 isozymes] kinase: (2R)-2-hydroxy-2- in 16S rRNA oligosaccharide carrier-protein] 1-oleoyl-sn homoserine kinase kinase dehydratase: cystathionine gamma- enzyme: ybiY dehydratase: α-D- a non 5'-monophosphate hydroxyC34:1- kinase II: aroL in heterodimer L-homoserine subunit: leuD yhaD (5Z,8Z,11Z,14Z,17Z) peptidoglycan peptidoglycan (indol-3-yl)acetaldehyde pseudouridine reductase phosphatidylserine -glycerol 3- shikimate 3-phosphate kinase: thrB I: aroK 2,3,4,5- synthase: metB ygcX galactosylated glyoxylate a phosphatidylglycerophosphate I: aroK with HisH, ilvD ornithine [+ 5 isozymes] putative butanoate 5-dehydro-4- (enterobacterial common antigen dTDP galactopyranose coenzyme A ser tetrapeptide, tetrapeptide, 5'-phosphate [acp] (NADH): fabI tetrahydropyridine- acetaldehyde 3-phospho- -icosapentaenoate decarboxylase: psd phosphate shikimate 3-phosphate shikimate shikimate imidazole glycerol (3S)-3-methyl-2- 2-isopropylmaleate carbamoyltransferase kinase: tdcD monomer)-undecaprenyl diphosphate galactose acceptor glycan chain 1 glycan chain 2 5-enolpyruvylshikimate- O-phospho- 2-carboxylate N- deoxy-D-glucarate D-glycerate 1-acyl-sn-glycerol- kinase phsphate synthase oxopentanoate superpathway of L-methionine 1: argI acetate non-essential 3-phosphate kinase homoserine homoserine L-cystathionine acetyl-CoA formate alcohol a palmitoyl-[acp] a phosphatidylethanolamine 3-phosphate L-homoserine succinyltransferase: isopropylmalate biosynthesis (transsulfuration) phosphatidylglycerophosphate 5-enolpyruvylshikimate- synthetase: aroA II: aroL II: aroL holoenzyme: hisF transsuccinylase: kinase: thrB branched-chain kinase: ackA dehydrogenase: threonine dapD isomerase a CDP- S-(2-hydroxyacyl) α-D-galactose an N-terminal L- β-D-fructofuranose phosphatase: pgpB acyltransferase: 3-phosphate metA amino-acid [DNA] 4-acetamidobutanal sn-glycerol benzaldehyde long chain an aryl sulfate a cis-delta11-3- 5-enolpyruvoyl- shikimate 3- shikimate 3- N-succinyl- oxaloacetate acetate adhP ammonium ATP hydrogencarbonate glutathione 1-phosphate alanyl-[S18 protein asp a protein (E)-2-pentenol plsC synthetase: aroA synthase: subunit: leuD cystathionine beta-lyase L-citrulline aldehyde phosphotransacetylase: pta tartronate diacylglycerol UTP 1-phosphate 3-phosphate polyphosphate oxo-C30:1-[acp] phosphatidylglycerophosphatase: shikimate 3-phosphate phosphate phosphate D-erythro-1-(imidazol-4- 2-amino-6- cys O-phospho- aminotransferase: [+ 2 isozymes] of 30S ribosome] aldehyde aldehyde putative putative bisoleoyl thrC AICAR (2R,3S)-3- (beta-cystathionase): metC dehydrogenase: semialdehyde ribosomal- glycerol-3- 3-oxoacyl- pgpA 5-enolpyruvoyl- yl)-glycerol 3-phosphate ketopimelate O-succinyl-L- L-homoserine ilvE aspartate L-arginine biosynthesis I (via L-ornithine) dehydrogenase: aspartate dehydrogenase: polyphosphate arylsulfatase protease: aldehyde phosphatidate chorismate 5-enolpyruvylshikimate- 5-enolpyruvylshikimate- isopropylmalate argininosuccinate aldA pyruvate fermentation to acetate and (S)-lactate I protein-alanine phosphate [acyl-carrier- shikimate 3-phosphate ethanol exonuclease I, 3 --> 5 specific; probable galactose-1- putative aminotransferase: degS reductase: palmitate thr 3-phosphate 3-phosphate imidazole glycerol N-succinyldiaminopimelate- homoserine threonine aminotransferase: aspC L-homocysteine acetyl phosphate putative carbamate CDP-diacylglycerol acetyltransferase: aldA acyltransferase: aldH kinase: ppk regulator: aslB protein] a phosphatidylglycerol synthase: ile 3-isopropylmalate synthetase: argG [+ 4 isozymes] deoxyribophosphodiesterase: hydroxyacylglutathione phosphate aldolase: S1565 aspC [+ 4 isozymes] chorismate synthetase: aroA synthetase: aroA phosphate aminotransferase: argD synthase: kinase: arcC phosphotidylhydrolase: cdh rimJ [+ 3 isozymes] α ωplsB [+ 3 isozymes] [+ 2 isozymes] S1557 aroC dehydrogenase: pyruvate sbcB hydrolase: gloB uridylyltransferase: an N-terminal N-acetyl- 1-C16:0- , - long chain reductase: acyl-CoA synthase: 5-enolpyruvoyl- 5-enolpyruvoyl- asp glu pyruvate decarboxylation to acetyl CoA I D-galactonate degradation [+ 2 isozymes] oxaloacetate benzoate threonine dehydratase and N-succinyl- homoserine thrC tetrahydropteroyltriglutamate L-arginino-succinate putative galT L-alanyl-[S18 protein 4-acetamidobutanoate dicarboxyl-2- a phenol a cis-delta11-3-fabG a peptide (E)-2-pentenal synthetase, long- chorismate leuB D-glycerate polyphosphate cardiolipin synthase: cls cardiolipin synthase: cls aroC deaminase shikimate 3- shikimate 3- histidinol-phosphate L,L-2,6- transsuccinylase: B12-dependent methyltransferase: metE acetaldehyde kinase: tdcD of 30S ribosome] lysophosphatidate chain-fatty-acid-- (2S)-2-isopropyl- N-acetylglutamate a [pyruvate dehydrogenase a 2'- CMP hydroxyC30:1- (dehydratase) phosphate phosphate phosphatase: hisB diaminopimelate metA thr aspartokinase II homocysteine-N5- argininosuccinate acetate D-galactonate pyruvate dehydrogenase L-lactate a phosphatidate a 2-hydroxy gln B12-dependent synthase; alcohol E2 protein] N 6 -lipoyl-L-lysine deoxyribonucleoside [DNA] carbamoyl phosphate glutathione DHAP D-glyceraldehyde [acp] CoA ligase: fadD chorismate chorismate chorismate 3-oxosuccinate and homoserine (d: aceF aceE dehydrogenase: lldD carboxylate UDP-α-D-galactose : ilvA 3-(imidazol-4-yl)-2- N-succinyl- cystathionine methyltetrahydrofolate lyase: argH kinase: ackA pyruvate chorismate chorismate dehydrogenase II: metL homocysteine-N5- amino acid dehydrogenase: 5'-monophosphate palmitoyl-CoA Ptd Gro [+ 2 isozymes] synthase: synthase: diaminopimelate transmethylase: metH pyruvate dehydrogenase 2 mutase-T and lyase: ubiC oxopropyl phosphate gamma- methyltetrahydrofolate adhP aroC acetyltransferase: acetate pyruvate 2-phospho- chorismate aroC deacylase: dapE synthase: metB [+ 2 isozymes] arg (dihydrolipoyltransacetylase prephenate anthranilate (2Z)-2-aminobut- histidinol-phosphate transmethylase: metH argA [+ 2 isozymes] D-glycerate acetyl-CoA (S)-lactate lyase: ubiC component): aceF dehydrogenase 2-dehydro-3-deoxy- (3E,5Z)-tetradeca- a ribonucleoside a cytidine 2498 a supercoiled dehydrogenase: synthetase: 2-enoate chorismate chorismate L,L- 4-methyl-2- cob(II)inamide ATP fumarate (S)-dihydroorotate glutathionylspermidine a 9S rRNA canavaninosuccinate galactitol a cis,cis-delta5,17-3- 3-ethylmalate an aldehyde a cis-delta21-3- a nucleoside (E)-2-hexenol aminotransferase: L-aspartyl-4-phosphate N-acetyl-L- (decarboxylase D-galactonate 2',3'-cyclic anthranilate tyrA diaminopimelate oxopentanoate met ethanol lipoamide 3,5-dienoyl-CoA in 23S rRNA duplex DNA oxo-C40:1-[acp] diphosphate trpD trpE hisC component): aceE phosphotransacetylase: pta phosphate putative aldose hydroxyC36:2[acp] aldehyde DNA putative synthetase: chorismate chorismate L-cystathionine glutamate dehydrogenase 2-oxo-3- 3-isopropylmalate 3-oxoacyl- nucleoside chorismate branched-chain 2:3-cyclic-nucleotide reductase: yafB 3-oxoacyl-[acyl- dehydrogenase: hypothetical helicase aldehyde trpD trpE mutase-T and mutase-T and diaminopimelate aspartate-semialdehyde glycine biosynthesis II (NADH): lpdA deoxygalactonate cob(I)alamin dihydro-orotate acyl-CoA dehydrogenase: [acyl-carrier- diphosphate mutase-P and L-histidinol phosphate amino-acid acetylglutamate citrate degradation glutathionylspermidine RNase 2-phosphodiesterase: argininosuccinate putative aldehyde carrier-protein] aldA protein: ygdE IV: helD reductase: Tetrapyrrole Biosynthesis anthranilate prephenate prephenate epimerase: dapF cystathionine kinase: dgoK acetyl phosphate thioesterase leuB protein] 2-iminobutanoate aminotransferase: dehydrogenase: asd kinase: argB a [pyruvate dehydrogenase adenolsyltransferase: dehydrogenase: cpdB reductase: S1557 reductase: fabG kinase: ndk prephenate beta-lyase (beta- a [glycine-cleavage a [pyruvate dehydrogenase E2 2-dehydro-3-deoxy- synthetase/amidase: gsp E: rne lyase: argH [+ 3 isozymes] a 2-O- [+ 5 isozymes] reductase: S1557 dehydrogenase: dehydrogenase: imidazole glycerol ilvE 6 btuR pyrD II: tesB anthranilate dehydratase: anthranilate synthase meso- 6 E2 protein] N -S- a ribonucleoside a cis,cis-delta5,17- 2-oxovalerate 2498 a single a nucleoside cystathionase) complex H protein] N glycine an acetyl-holo [citrate 6 D-galactonate D-galactopyranose a carboxylate methylcytidine fabG (E)-2-hexenal tetrapyrrole biosynthesis tyrA tyrA phosphate N-acetylglutamyl- protein] N -dihydrolipoyl-L-lysinepyruvate dehydrogenase putative kinase: tdcD stranded DNA a cis-delta21-3- triphosphate superpathway of heme b biosynthesis siroheme biosynthesis pheA component II, glutamine diaminopimelate L-aspartate 4-semialdehyde -dihydrolipoyl-L-lysine citrate lyase acyl-carrier protein] acetyldihydrolipoyl-L-lysine 6-phosphate 3'-phosphate 3-oxo-C36:2-[acp] in 23S rRNA I (from glutamate) dehydratase and : metC decarboxylase, phosphate (dihydrolipoyltransacetylase acetate kinase: ackA hydroxyC40:1- from uroporphyrinogen-III heme b biosynthesis anthranilate synthase amidotransferase and chorismate chorismate leu orotate (3E,5Z)- histidinol-phosphate P protein of component): aceF adenosylcobinamide succinate glutathione spermidine coenzyme A a 5S rRNA an rRNA fragment L-canavanine fumarate [acp] I (aerobic) component II, glutamine phosphoribosylanthranilate mutase-P and mutase-P and diaminopimelate aspartokinase II aminomethyltransferase (T N-acetyl-gamma- triphosphate tetradecadienoate uroporphyrinogen-III prephenate 2-oxobutanoate L-homocysteine glycine cleavage citrate lyase beta chain acetate glu uroporphyrinogen-III amidotransferase and transferase: trpD prephenate prephenate phosphatase: hisB decarboxylase: lysA and homoserine protein; tetrahydrofolate- glutamylphosphate uroporphyrinogen system: gcvP (acyl lyase subunit): citE glutamate uroporphyrinogen-III phosphoribosylanthranilate dehydratase: dehydratase: dehydrogenase II: metL dependent) of glycine reductase: argC D-gluconate III methylase: hemX N-(5-phosphoribosyl) acetolactate histidinol tetrahydropteroyltriglutamate D-glyceraldehyde tRNA uroporphyrinogen uroporphyrinogen transferase: trpD pheA pheA lys aspartokinase cleavage system: gcvT lipoamide N-acetyl-L- degradation pyruvate chorismate chorismate -anthranilate synthase methyltransferase: metE B12-dependent glycine 3-phosphate adenine 2503 (R)-3-(phenyl) a 1,2-diacyl- CTP adenosine a (3R)-3- (indol-3-yl) synthetase, decarboxylase: hemE uroporphyrinogen decarboxylase: hemE I, homoserine dehydrogenase glutamate 5- a citryl-holo [citrate glutathione dehydroascorbate cinnamoyl-CoA (-)-dehydrodiconiferyl alcohol L-arabinitol pyridoxal an aldehyde DNA with lesion phytenal a cis-delta19-3- an aldehyde N-(5-phosphoribosyl) mutase-P and mutase-T and III, large oxidoreductase for homocysteine-N5- [+ 2 isozymes] decarboxylase, in 23S rRNA lactate sn-glycerol 2',3'-cyclic hydroxyoctadecanoyl- L-ornithine acetaldehyde III methylase: cysG N-(5-phosphoribosyl) prephenate prephenate B12-dependent (NADH): lpdA semialdehyde lyase acyl-carrier protein] D-gluconate acetyl-CoA putative aldose oxo-C38:1-[acp] catalytic coproporphyrinogen III -anthranilate prephenate prephenate L-histidinal:NAD+ methyltetrahydrofolate dehydrogenase I: thrA P protein of pyruvate fermentation to acetate and lactate II alcohol monophosphate [acp] aldehyde putative aldehyde putative putative coproporphyrinogen III precorrin-1 anthranilate subunit: ilvI homocysteine-N5- a [glycine-cleavage acetylornithine delta- gluconokinase (3R)- 3-oxoacyl-[acyl- 3-oxoacyl- subunit: gltX glycine6 cleavagea [glycine-cleavage dehydrogenase: 2:3-cyclic-nucleotide reductase: yafB probable ornithine dehydrogenase: excinuclease dehydrogenase: aldehyde aldehyde an L-glutamyl- N-(5-phosphoribosyl) dehydratase: dehydrogenase: [+ 2 isozymes] chorismate chorismate and L- methyltetrahydrofolate transmethylase: metH complex H protein] N - aminotransferase: hydrogencarbonate citrate lyase beta chain hydroxymyristol carrier-protein] [acyl-carrier- isomerase L-homoserine complex H protein] N 6 2: gntK oxidized 2-phosphodiesterase: aminotransferase: Glu uroporphyrinogen anthranilate pheA tyrA histidinol:NAD+: hisD system: gcvP D-gluconate hypothetical flavodoxin diacylglycerol adhP putative aldehyde aldA subunit: S1602 aldH reductase: reductase: [tRNA ] and indole-3- (S)-2-aceto-2- mutase-P and mutase-T and transmethylase: metH aminomethyldihydrolipoyl- argD (acyl lyase subunit): citE acetyl-CoA pyruvate glutaredoxin: acyl carrier reductase: fabG protein] -[(R)-lipoyl]-L-lysine 6-phosphate protein: ygfB 1: fldA cpdB reductase: S1557 ygjG [+ 3 isozymes] [+ 3 isozymes] [+ 3 isozymes] S1557 S1557 O2-independent III methylase: hemX isomerase glycerolphosphate hydroxybutanoate prephenate prephenate L-lysine lipoamide carbamoyl- kinase: dgkA putative aldehyde protein reductase: glutamyl- histidinal N-acetyl-L- L-lactate grxA L-glutamate-5- 4-pyridoxolactone DNA without coproporphyrinogen uroporphyrinogen and indole-3- 3-phenyl-2- 3-(4-hydroxyphenyl) dehydrogenase: met homoserine dehydrogenase phosphate oxaloacetate phosphotransacetylase: pta reductase: S1557 3'-AMP dehydratase: fabZ L-arabinopyranose a carboxylate phytenate fabG (indol-3-yl)ethanol an alcohol tRNA protoporphyrinogen IX synthetase: trpC ketol-acid dehydratase: ornithine dehydrogenase: lldD (-)-dehydrodiconiferyl lesion a cis-delta19-3- III oxidase: hemN III methylase: cysG glycerolphosphate oxopropanoate pyruvate L-arginine biosynthesis II (acetyl cycle) transsuccinylase: metA (NADH): lpdA synthase, a (2E)-octadec- semialdehyde 1-(2- pheA tyrA oxidoreductase for 2503 hydroxyC38:1- reductase: protoporphyrinogen IX reductoisomerase: acetyl phosphate (S)-lactate a 2-methyladenine (R)-3-(phenyl) CDP aldehyde synthetase: trpC tyrosine tyrosine 3-(4- acetylornithine arginine 5'-deoxyadenosine L-ascorbate GSSG cinnamate a phosphatidate 2-enoyl-[acp] hemA precorrin-2 HemY protein: hemY carboxyphenylamino) ilvC 3-phenyl-2- L-histidinal:NAD+ in 23S rRNA met lactoyl-CoA [acp] 1-(2- aminotransferase: aminotransferase: -1-deoxy-D-ribulose hydroxyphenyl) and L- cys O-succinyl-L-homoserine deacetylase: specific: (S)-4-amino-5- protoporphyrinogen IX [+ 2 isozymes] (R)-2,3-dihydroxy- oxopropanoate N-acetylglutamyl-phosphate putative kinase: tdcD carboxyphenylamino) tyrB tyrB 5-phosphate pyruvate histidinol:NAD+: hisD N-acetyl-gamma- argE carB carA oxopentanoate uroporphyrinogen 3-methylpentanoate tyrosine CO gly protoporphyrin IX -1-deoxy-D-ribulose tyrosine glutamylphosphate 2 acetate kinase: ackA III methylase: cysG [+ 2 isozymes] N-(5-phosphoribosyl) dihydroxyacid aminotransferase: homoserine L-ornithine carbamoyl UDP-N-acetyl- ADP-L-glycero-β- α-Kdo-(2->4)- a glucosylated N-acetyl-β- guanosine N 2 -succinyl- 1-deoxy- RNase E glutamate-1- 5-phosphate tyr aminotransferase: his acetylglutamate reductase: argC di-trans,octa-cis- UDP-α-D-glucose 1-aminocyclopropane- stachyose glycerol L-quinate an aldehyde propan-1-ol 1-octanal anthranilate dehydratase: tyrB N-acetylglutamate transsuccinylase: metA phosphate acetate α-D-glucosamine D-manno-heptose α-Kdo-(2->6)- glycogenin neuraminate 2',3'-cyclic L-glutamate 5- a palmitoyl-[acp] D-xylulose degradation semialdehyde N-(5-phosphoribosyl) phe isomerase tyrB kinase: argB undecaprenyl phosphate 1-carboxylate sirohydrochlorin ferrochelatase: hemH ilvD [+ 2 isozymes] synthase; amino acid lipid IV (E. coli) monophosphate putative aldose semialdehyde aldehyde alcohol aldehyde substrate mRNA aminotransferase anthranilate L-alanine cystathionine gamma- A putative 1- aldehyde putative enoyl-[acyl- xylulokinase: protoporphyrin IX and indole-3- L-proline biosynthesis acetyltransferase: ornithine Aldehyde Degradation 2:3-cyclic-nucleotide reductase: yafB dehydrogenase: dehydrogenase: dehydrogenase: (aminomutase) isomerase (3S)-3-methyl-2- tyr biosynthesis I synthase: metB UDP- glycogen N-acetylneuraminate aminocyclopropane- alpha- dehydrogenase: oxidoreductase: carrier- RNase uroporphyrinogen glycerolphosphate I (from L-glutamate) argA carbamoyltransferase Secondary Metabolite Degradation heptosyl 2-phosphodiesterase: putative aldehyde aldA adhP aldH xylB : hemL protoheme oxopentanoate phe gln L-selenocysteine biosynthesis I (bacteria) GlcNAc:undecaprenylphosphate synthase: lyase (aldolase) 1-carboxylate galactosidase: ydiB protein] E: rne III methylase: cysG and indole-3- synthetase: trpC glu N-acetyl-L-glutamate N-acetyl-L-glutamate 5-semialdehyde L-serine biosynthesis I transferase cpdB reductase: S1557 aldA 1-deoxy-D- ferrochelatase: 3-methyl-2- 1: argI methylglyoxal degradation I glgA melA [+ 3 isozymes] [+ 2 isozymes] [+ 3 isozymes] glycerolphosphate branched-chain L-lactaldehyde methylglyoxal GlcNAc-1-phosphate transferase: rfe I: rfaC : nanA deaminase: yedO [+ 3 isozymes] reductase 5-aminolevulinate hemH (1S,2R)-1-C-(indol-3- oxobutanoate L-cystathionine anhydromuropeptides recycling I L-lactaldehyde L-glyceraldehyde N 2 - 3-dehydroquinate xylulose 5- an mRNA fragment siroheme synthetase: trpC amino-acid branched-chain glu carbamoyl- superpathway of hexitol degradation (bacteria) 2-oxobutanoate 3'-GMP a carboxylate 1-propanal octanoate (NADH): fabI superpathway of L-serine ser sec 3-phospho-D-glycerate degradation (aerobic) degradation III degradation phosphate yl)glycerol 3-phosphate amino-acid gamma- phosphate acetylornithine delta- a tRNA N-acetyl-α-D-glucosaminyl- β α succinylglutamate a (2E)-hexadec- 5-aminolevulinate protoheme aminotransferase: L-citrulline GlcNAc-1,6- methylglyoxal (anaerobic) UMP heptosyl- a glucosylated UDP N-acetyl- -D- -D- (1S,2R)-1-C-(indol-3- and glycine biosynthesis I glutamate synthase, arginine aminotransferase: selenide D-3-phosphoglycerate diphospho-ditrans,octacis ADP pyruvate raffinose 2-enoyl-[acp] dehydratase; ilvE aminotransferase: cystathionine beta-lyase lactoylglutathione (S)-lactaldehyde methylglyoxal Kdo -lipid IV glycogenin mannosamine galactopyranose yl)glycerol 3-phosphate specific: carB carA argD dehydrogenase: serA anhMurNAc- galactitol (S)-lactaldehyde 2 A tryptophan L-cysteine biosynthesis I ilvE γ-L-glutamylkinase: proB (beta-cystathionase): metC putative -undecaprenol porphobilinogen 3-phospho-D-glycerate ammonia selenophosphate argininosuccinate L-Ala-γ-D-Glu- lyase: gloA aldehyde tryptophan synthase, ile 3-phosphooxypyruvate predicted (R)-S- L-1,2-propanediol synthase: hemB D-3-phosphoglycerate val 5-phosphate assimilation cycle III L-ornithine synthase: selD DAP-D-Ala dehydrogenase aldose synthase, carbamoyl phosphate synthetase: argG oxidoreductase: alpha N-acetyl-L-ornithine L-homocysteine transporter lactoylglutathione reductase: UDP-N-acetyl- 10 2 dehydrogenase: serA ser gamma- 3-phosphoserine B (lactaldehyde RNase III mRNA a pyrimidine nucleoside a methyl-esterified an N - N -succinyl- D-gluconate porphobilinogen alpha protein: trpA ser L-arginino- fucO trans,octacis- a phenolic donor raffinose D-threo-isocitrate butan-1-ol a D-hexose pyruvate alanine-alpha- sec N-acetylmuramoyl- complex of probable dehydrogenase) yafB (S)-propane- α-D-glucosamine homogalacturonan 13-DPG thr a myristoyl-[acp] 3-phosphooxypyruvate glutamylphosphate glu superpathway of L- an L-seryl-[tRNA ] selenophosphate aminotransferase: serC decaprenyl phosphate processing substrate formyltetrahydrofolate L-ornithine 6-phosphate protein: trpA ketoisovalerate/ ammonium tetrahydropteroyltriglutamate succinate GALACTITOL: hydroxyacylglutathione hydroxyacetone 1,2-diol thiol peroxidase: tpx gluconate-6- alcohol serine reductase: proA ornithine asparagine biosynthesis l-alanine : aldB phosphoglyceromutase probable ornithine isocitrate enoyl-[acyl- glucokinase: pyruvate porphobilinogen B12-dependent D-sorbitol 6-phosphate dihydropteridine threonine ser valine-pyruvate carbamoyltransferase methyltransferase: metE argininosuccinate amidase I: amiA gatA gatB gatC hydrolase: gloB [+ 4 isozymes] hypothetical putative 1: gpmA catalase; alpha- aminotransferase: dehydrogenase: phosphate dehydrogenase: oxidase: deaminase, indole 3-phosphoserine indole acetyltransferase: L-glutamate-5- O-phospho-L-serine putative UDP- carrier- glk transaminase 1: argI homocysteine-N5- B12-dependent selenocysteine synthase: (S)-lactate RNase III: rnc protein: yeiK hydroperoxidase reductase: hmpA dehydrogenase: dehydrogenase: adhP hydroxymethylbilane aminotransferase: serC cysE glutamine lyase: argH glucitol (sorbitol) (R)-lactate GlcNAc:undecaprenylphosphate pectinesterase: phosphoglyceromutase galactosidase: ygjG icdA protein] poxB C: avtA semialdehyde asp methyltetrahydrofolate N-acetyl-β-D- L-alanyl-γ-D- galactitol 1-phosphate aldose 2 tdh gnd synthetase: glnA homocysteine-N5- L-seryl-tRNA (Ser) RNase D: rnd ybhC HPI(I): katG melA an N 10 -formyl- N -succinyl- [+ 2 isozymes] reductase D-hexose 6- synthase: hemC transmethylase: metH 3-phosphoserine glucosamine-1,6- -6-phosphate L-lactate reductase: GlcNAc-1-phosphate transferase: rfe 2: gpmB a phenoxyl radical 2-oxoglutarate D-ribulose tryptophan tryptophan O-acetyl-L-serine methyltetrahydrofolate selenium transferase: selA arg glutamyl-meso-2,6- D-lactate 2,3-diphospho- L-glutamate 5- aminoacetone 1-butanal phosphate acetyl phosphate O-phospho-L-serine hydrogen sulfide putative glutamine galactitol-1- dehydrogenase: yafB 7,8-dihydrofolate 5-phosphate (NADH): fabI synthase, synthase, ala L-citrulline transmethylase: metH phosphatase: serB anhydro-N-acetyl- diaminopimeloyl- dehydrogenase: D-ribofuranose a pyrimidine base D-glycerate of a phenolic donor semialdehyde preuroporphyrinogen synthetase: S1384 asparagine asparagine phosphate srlD dehydrogenase, N-acetyl-α-D- UMP α-D- a (2E)-tetradec- beta beta β-D-muramate D-alanine lldD (S)-propane- RNase III processing a homogalacturonan sucrose synthetase synthetase dehydrogenase: FAD protein: dld glucosaminyl-diphospho- an mRNA fragment MeOH galactopyranose 2-enoyl-[acp] protein: trpB 3-phosphoserine protein: trpB alanine (S)-1-pyrroline- an L-selenocysteinyl-[tRNA sec ] ser putative sorbitol- 1,2-diol product mRNA uroporphyrinogen cysteine synthase argininosuccinate met gatD trans,octacis-decaprenol phosphatase: serB racemase 5-carboxylate B: asnB B: asnB 6-phosphate 2- pyruvate pyruvate III synthase: hemD B, O-acetylserine gln synthetase: argG 1: alr asparagine keto-D-tagatose D-mannitol 1-phosphate dehydrogenase: sulfhydrolase B: cysM pyrroline-5- superpathway of L-aspartate L-alanyl-γ-D- Detoxification trp synthetase 1,6-anhydro-N- 6-phosphate F uroporphyrinogen-III trp ser alanine carboxylate glutamate L-arginino-succinate sorD a single CTP D-gluconate sucrose 6 cysteine synthase asn and L-asparagine biosynthesis acetyl-β-muramate glutamyl-meso- 2-oleoylglycerol seleno-L- a 2-lysophosphatidylcholine formamide uroporphyrinogen-III Ins(1,2,3,4,5,6)P 2-phosphoglycolate fluoroacetaldehyde D-threo-isocitrate phytol L-tartrate A: asnA keto-D-fructose 6 D-arginine 6-phosphate a stearoyl-[acp] -phosphate A, O-acetylserine racemase reductase: synthase: gltD gltB diaminopimelate mannitol-1- stranded DNA homocysteine 6-phosphate superoxide beta-hydroxydecanoyl uroporphyrinogen phosphoanhydride aldehyde gluconate-6- alcohol sucrose-6 serine L-glutamate sulfhydrolase A: cysK 2: dadX proC glutamate synthase, argininosuccinate phosphate arsenate 8-oxo-(d)GTP detoxification I arginine dependent isocitrate enoyl-[acyl- L-tartrate glu asp asn radicals degradation thioester dehydrase, III methylase: cysG phosphorylase; phosphoglycolate dehydrogenase: D-amino acid phosphate dehydrogenase: phosphate hydroxymethyltransferase: glyA biosynthesis III small subunit: gltD lyase: argH D-tagatofuranose dehydrogenase: detoxification triclosan acid resistance tetrahydropteroyltriglutamate dehydrogenase: carrier- dehydratase: D-ala asn aspartate asparagine periplasmic L- exonuclease diacylglycerol lysophospholipase trans-2-decenoyl- uroporphyrinogen pH 2.5 acid phosphatase: gph aldH dehydrogenase dehydrogenase: adhP hydrolase: pro N-acetyl-D- 6-phosphate mtlD II (glutaredoxin) resistance methyltransferase: metE icdA protein] ttdB ttdA aminotransferase: synthetase asparaginase superoxide VII: xseA xseB kinase: dgkA L(2): pldB phosphatase: appA subunit: dadA S2567 2-oxoglutarate muramate 6- ACP isomerase: fabA III methylase: hemX D-myo-inositol [+ 3 isozymes] gnd [+ 2 isozymes] reductase gly cys glu arg aspC B: asnB II: ansB putative superoxide arsenate dGTP GTP a trans-2- arg glycolate oxalosuccinate 5-guanidino-2- D-ribulose oxaloacetate glutamate synthase, phosphate SeMet hydrogen cyanide precorrin-2 (1,2,3,4,5)- fluoroacetate phytenal (NADH): fabI sucrose asp tagatose 6- F6P dismutase, arsenate enoyl-[acyl- biosynthetic arginine 1-oleoyl-sn oxopentanoate 5-phosphate small subunit: gltD asparagine [+ 2 isozymes] CDP pentakisphosphate a (2E)-octadec- phosphate manganese: reductase: carrier protein]enoyl-[acyl- decarboxylase: speA a single-stranded sn-glycero-3- glutamate synthase, synthetase asp a ribonucleoside -glycerol 3- a carboxylate 2-enoyl-[acp] aspartate kinase 2: agaZ 6-phosphofructokinase sodA arsC 8-oxo-dGTP 8-oxo-GTP carrier- oligodeoxyribonucleotide phosphocholine large subunit: gltB A: asnA biodegradative arginine 5'-monophosphate phosphate N-acetyl-D- II: pfkB ammonia-lyase asn putative fructose- [+ 2 isozymes] hypothetical protein] decarboxylase: adiA glu (aspartase): aspA glucosamine bisphosphatase: fbp 6-phosphofructokinase hydrogen 7,8-dihydro-8- reductase agmatine tagatose 6- peroxide arsenate oxoguanine- 6-phosphate I: pfkA (NADH) 3-methyl-2- 5,10-methylene- adenine 1518 / 3-methoxy-4- a double a medium-chain RNase G degradation 3-β-hydroxyandrost- a (9Z)-3- fumarate phosphate reductase: a β-D glucoside uroporphyrinogen-I acetamide oxaloacetate D-xylose (S)-carnitinyl-CoA L-gulonate N-acetylglucosamine- catalase; triphosphatase: 1519 2,3,4-saturated trp oxooctacos- β-D-fructose 1,6- S2710 : fabI oxobutanoate tetrahydromethanopterin adenine in 16S rRNA hydroxyphenylglycol stranded DNA substrate mRNA 5-en-17-one 3-sulfate kinase 1: gatZ mutT 8-oxo-GMP a 2,3,4-saturated putative aldose putative 6-phosphate putative hydroperoxidase S-adenosylmethionine- alcohol glutathionylspermidine phosphoenolpyruvate DNA-specific fatty acyl CoA ribonuclease putative 9-enoyl-[acp]3-oxoacyl- carnitine D-tagatofuranose bisphosphate arsenite fatty acyl-[acp] uroporphyrinogen putative acyl-CoA reductase: yafB aldehyde deacetylase: agaA epimerase/ HPII(III): katE 3-methyl-2-oxobutanoate 6-N,N-adenosyl (rRNA) dehydrogenase: synthetase/amidase: gsp carboxykinase: pckA endonuclease G: cafA arylsulfatase: tryptophanase: [acyl-carrier- racemase: 1,6-bisphosphate 8-oxo-dGMP beta-D-glucoside decarboxylase: hemE dehydrogenase: reductase: N-acetylglucosamine- DHAP aldolase: sgaE catalase; hydroxymethyltransferase: dimethyltransferase: adhP [+ 5 isozymes] phosphoenolpyruvate I: endA RNase E: rne ybjU putative aldehyde tnaA protein] caiD Aminoacyl-tRNA Charging glucohydrolase: bglX ksgA yafH reductase: S1557 S1557 tRNA charging 6-phosphate hydroperoxidase panB 6 1518 putative aldehyde carboxylase: ppc 3-β-hydroxyandrost- reductase: tagatose- [+ 3 isozymes] N -dimethyladenine coproporphyrinogen I acetate phosphoenol a 5'-phosphooligonucleotide a medium-chain an mRNA fragment N-Formyl-L- (R)-carnitinyl-CoA aldehydo-D- deacetylase: nagA HPI(I): katG 6 1519 reductase: S1557 xylitol fabG bisphosphate triosephosphate /N -dimethyladenine 3-methoxy-4- pyruvate (2E)-2-enoyl-CoA 5-en-17-one kynurenine a cis-delta9-3- glucuronate D-glucosamine arsenite a non glucosylated in 16S rRNA phe a tRNA Phe aldolase 1: gatY isomerase: tpiA O D-glucopyranose hydroxyphenylglycolaldehyde hydroxyC28:1- 6-phosphate 2 2-dehydropantoate THMPT D-glucose acceptor [acp] D-glyceraldehyde lys a tRNA Lys phosphoglucosamine phenylalanyl-tRNA mutase: S2704 3-phosphate a tRNA Ala ala arg a tRNA Arg asn tRNA Asn tRNA asp asp gly a tRNA Gly cys a tRNA Cys gln a tRNA Gln glu a tRNA glu his a tRNA His ile a tRNA Ile leu a tRNA Leu elongator tRNA Met met pro a tRNA Pro ser a tRNA ser thr a tRNA Thr trp a tRNA Trp tyr a tRNA Tyr synthetase: pheT pheS initiator tRNA Met met val a tRNA Val glyceraldehyde- an N 1 -ethyladenine 6-[1-hydroxyethyl]-7- (3,4-dihydroxyphenyl) a single (R)-methylmalonyl- 5-chloro-5- GDP-α-D- an insertion a double α-D-glucosamine 2-oxoglutarate hydrogenobyrinate propionamide acrylamide oxaloacetate a sugar alcohol (S)-malate an mRNA phenylalanyl-tRNA lysine tRNA synthetase: lysS 3-phosphate Amino Acid Degradation in DNA methyl-7,8-dihydropterin acetate stranded DNA CoA deoxy-D-ribonate mannose sequence stranded DNA 1-phosphate phosphoenolpyruvate putative aldehyde GDP-D- element IS30 synthetase (pheST) operon tryptophan tRNA dehydrogenase putative nicotinic acid 7, 8-dihydro-6- glutathionylspermidine glutathionylspermidine methylmalonyl- dihydroxyacid malate DNA alanyl-tRNA arginine tRNA asparagine tRNA aspartate tRNA glycine-tRNA cysteine tRNA glutamine tRNA glutamate tRNA synthetase, histidine tRNA isoleucine tRNA leucine tRNA putative lysyl-tRNA methionine tRNA proline tRNA serine tRNA threonine tRNA tyrosine tRNA reductase: S1557 mannose putative RNase N-acetyl mononucleotide:5,6- hydroxymethylpterin- homoprotocatechuate synthetase/amidase: gsp synthetase/amidase: gsp carboxykinase: pckA endonuclease CoA mutase dehydrogenase: gyrase: synthetase: alaS synthetase: argS synthetase: asnS synthetase: aspS leader peptide: pheM synthetase: glyS glyQ synthetase: cysS synthetase: glnS catalytic subunit: gltX synthetase: hisS synthetase: ileS synthetase: leuS synthetase: yjeA synthetase: metG synthetase: proS synthetase: serS synthetase: thrS synthetase: trpS synthetase: tyrS valine tRNA synthetase: valS A: gapA L-valine degradation I alkylated dehydratase: transposase: glucosamine- L-threonine degradation I L-serine degradation D-serine L-tryptophan dimethylbenzimidazole (DMB) pyrophosphokinase: dioxygenase: hpaD phosphoenolpyruvate IV: nfo putative aldose (MCM): sbm dehydratase: T: rnt L-glutamine L-lysine DNA repair [+ 5 isozymes] [+ 5 isozymes] ilvD mdh S2705 gyrB gyrA 1-phosphate 13-DPG degradation phosphoribosyltransferase: folK 2-hydroxy-5- carboxylase: ppc reductase: yafB gmd degradation II degradation I degradation I protein: alkB [1-(2-amino-7-methyl-4-oxo- 5-chloro-4-hydroxy- GDP-4-dehydro- an insertion a negatively Ala Arg Asn asp Phe Gly Cys Gln Glu His Ile Leu Lys Met Met Pro ser Thr Trp Tyr Val uridyltransferase: cobB propanoate acrylate phosphoenol a 5'-phosphooligonucleotide succinyl-CoA oxaloacetate an mRNA fragment an L-alanyl-[tRNA ] an L-arginyl-[tRNA ] an L-asparaginyl-[tRNA ] an L-aspartyl-[tRNA ] an L-phenylalanyl-[tRNA ] a glycyl-[tRNA ] an L-cysteinyl-[tRNA ] an L-glutaminyl-[tRNA ] an L-glutamyl-[tRNA ] an L-histidyl-[tRNA ] an L-isoleucyl-[tRNA ] an L-leucyl-[tRNA ] an L-lysyl-[tRNA ] an L-methionyl-[elongator tRNA ] an L-methionyl-[initiator tRNA ] an L-prolyl-[tRNA ] an L-seryl-[tRNA ] an L-threonyl-[tRNA ] an L-tryptophanyl-[tRNA ] an L-tyrosyl-[tRNA ] an L-valyl-[tRNA ] val (via pyruvate) 7,8-dihydro-3H-pteridin- carboxymethylmuconate an aldose 2-oxopentanoate α-D-rhamnose sequence IS30 supercoiled DNA glmU thr ser hydrogenobyrinate semialdehyde pyruvate phosphoglycerate D-serine gln lys 6-yl)]ethyl diphosphate with integrated N-acetyl-α-D- threonine deaminase putative trp a,c-diamide kinase: pgk branched-chain D-serine carbamoyl- lysine acetaldehyde an adenine in DNA succinate transposon glucosamine (dehydratase): ilvA L-serine amino-acid dehydratase tryptophanase: phosphate decarboxylase 1-phosphate 3-phospho-D-glycerate [+ 2 isozymes] deaminase: aminotransferase: (deaminase) tnaA synthase large 2: ldcC N-acetyl (2Z)-2-aminobut-2-enoate S3363 2-aminoprop- ilvE : dsdA L-alanine subunit: carB cadaverine DNA combined with an [amino-group carrier protein]-C- glucosamine- phosphoglyceromutase 2-aminoprop- 2-enoate 5-amino-4- a [protein]-L- (5Z,8Z,11Z,14Z,17Z)-3- (2R,3S)-3- a 1,2-diacyl- (4Z)-2-oxohept- phosphoglyceromutase 2-aminoprop-[+ 2 isozymes] degradation I PRPP terminal-{N-[1-carboxy-5-oxo-5- 4-hydroxybenzoate a 5-methyltetrahydrofolate reduced riboflavin shikimate (R)-citramalate DHAP 2-deoxy-D-ribose starch 1: gpmA 3-methyl-2- 2-enoate [+ 8 isozymes] imidazolecarboxyamide exogenous DNA to form β-isoaspartate oxodocosapentaenoyl-CoA isopropylmalate sn-glycerol 4-enedioate 1-phosphate 1: gpmA (phosphooxy)pentyl]-L-glutamine} oxobutanoate 2-enoate glu a recombinational junctionputative crossover junction L-isoaspartate protein 3-oxoacyl-[acyl- putative 4- 5,10-methylene- sulfite reductase, putative isopropylmalate isopropylmalate 2-oxo-hept- alpha- uridyltransferase: phosphoglyceromutase N-acetyl-gamma- methylglyoxal diacylglycerol ribokinase: [+ 2 isozymes] ala tetrahydrofolate oxidoreductase: isomerase isomerase 3-ene-1, amylase: glmU 2: gpmB endodeoxyribonuclease: glutamylphosphate carboxylmethyltransferase carrier-protein] hydroxybenzoate alpha subunit: cysI rbsK 2-iminobutanoate alanine adenine synthase: mgsA kinase: dgkA 7-dioate malS UDP-N-acetyl- 2-iminopropanoate S1987 type II: pcm reductase: fabG decarboxylase: yclC reductase: metF [+ 2 isozymes] ydiB subunit: leuD subunit: leuD racemase 1: alr phosphoribosyltransferase: apt reductase: argC a protein L-β- hydratase: 2-deoxy-D-ribose a large- α 2-phospho-D-glycerate 2-iminopropanoate resolution of recombinational an [amino-group carrier protein]- (3R,5Z,8Z,11Z,14Z,17Z)-3- a 5,10- (2S)-2- -D-glucosamine [+ 2 isozymes] phenol riboflavin 3-dehydroshikimate citraconate methylglyoxal a phosphatidate branched glucan isobutanoyl-CoA 2-iminopropanoate alanine C-terminal-[N-(1-carboxy- isoaspartate hydroxydocosapentaenoyl-CoA methylenetetrahydrofolate isopropylmalate hpaH 5-phosphate UDP-N-glucosamine 1- junction formation α (4S)-4-hydroxy-2- racemase 2: dadX L-asparagine 5-oxopentyl)-L-glutamine] -methyl ester carboxyvinyltransferase: enolase: eno of two intact strands oxoheptanedioate D-ala degradation I AICAR murA 2-oxobutanoate pyruvate UDP-N-acetyl-α- D-arabitol phosphoenolpyruvate pyruvate D-amino acid D-glucosamine- degradation putative formate pyruvate asn methylacrylyl-CoA dehydrogenase (2E)-3-(5,6- β a long-linear acetyltransferase: ybiW periplasmic L- β -D-glucopyranose an organic (3R)-3- 54 (2R,3S)-3- a supercoiled enolpyruvate pyruvate subunit: dadA a (1->3)- -D-xylan 3,4-dihydroxyphenylglycol long chain a uracil in tRNA D-glucopyranose ethanol citraconate D-ribofuranose D-arabinitol [+ 5 isozymes] asparaginase dihydroxycyclohexa- 1-phosphate hydroperoxide hydroxyoctadecanoyl-CoA isopropylmalate duplex DNA a protein α-D-glucan UDP-N- phosphoenolpyruvate kinase II: pykA 4-enzyme alcohol polyphosphate II: ansB 1,3-dien-1-yl) putative beta- 3-oxoacyl-[acyl- tRNA (uracil-5-)- 3-isopropylmalate glucose alcohol isopropylmalate helicase: alpha- acetylenolpyruvoylglucosamine synthase: ppsA pyruvate protein, 3- propanoyl-CoA pyruvate dehydrogenase: adhP alkylhydroperoxide ribokinase: [+ 2 isozymes] putative prop-2-enoate phosphoglucomutase: carrier-protein] methyltransferase: dehydrogenase: dehydrogenase: dehydrogenase: isomerase hrpA endopeptidase: amylase: reductase: murB kinase I: pykF hydroxyacyl-CoA 2,3-dihydroxy-2,3- exopolyphosphatase: ppx reductase: ahpF ahpC rbsK D-xylulose L-tyrosine degradation asp xylanase: putative aldehyde ycjU reductase: fabG trmA leuB gcd adhP subunit: leuD [+ 4 isozymes] S0734 malS UDP-N-acetyl- dihydrophenylpropionate dehydrogenase; β 54 a linear malto- phosphotransacetylase: pta IV (to 4-methylphenol) yieL reductase: S1557 dehydrogenase: hcaB -D-glucose a 5-methyluracil 4-methyl-2- D-glucono- (2R,3S)-3- a single D-ribofuranose α-D-muramate xylulokinase: pyruvate 3-hydroxybutyryl- long chain an alcohol 3-oxooctadecanoyl-CoA acetaldehyde oligosaccharide 3,4-dihydroxyphenylglycolaldehyde 2,3-dihydroxy- 6-phosphate in tRNA oxopentanoate 1,5-lactone methylmalate stranded DNA a peptide 5-phosphate xylB CoA epimerase; trans-cinnamate polyphosphate tyr (1,3)-β- D-xylulose delta(3)-cis- propanoyl phosphate L-glutamate (1,3)-β-xylobiose (1,3)-β-xylotriose delta(2)-trans- tyrosine degradation IX (via xylotetraose UDP-N-acetyl- 5-phosphate aminotransferase: enoyl-CoA putative kinase: tdcD 4-aminobutanoate) α-D-muramoyl- L-arginine degradation III 3-(4- tyrB isomerase; acetate kinase: ackA 1498 γ (arginine decarboxylase/ phosphatidylglycerolphosphate a 5,10- a monocarboxylic α (11Z,14Z,17Z)-3- a uracil uridine L-alanyl- -D- enoyl-CoA hydroxyphenyl) glu 5-hydroxytryptophol F6P an -limit dextrin a primary alcohol L-cysteate D-glucopyranose a quinone ribulose estrone 3-sulfate D-altropyranose glutamyl-meso-2,6- agmatinase pathway) pyruvate (1-oleoyl, 2-palmitoyl) methenyltetrahydrofolate acid amide oxoicosatrienoyl-CoA in 16S rRNA uridine/ hydratase: fadB propanoate glutamate phosphatidylglycerophosphatase: alcohol glutathionylspermidine 4-α- 3-oxoacyl-[acyl- putative aldehyde aspartate glucose quinone putative L-fucose diaminopimelate 6-phosphofructokinase L-ribulokinase: cytidine decarboxylase serine dehydrogenase: adhP glucanotransferase: carrier-protein] aminotransferase: dehydrogenase: oxidoreductase: hypothetical isomerase: (S)-3-hydroxy- arg pgpA synthetase/amidase: gsp reductase: S1557 araB arylsulfatase: kinase: udk L-threonine isozyme: gadA L-aspartate hydroxymethyltransferase: glyA putative aldehyde II: pfkB malQ gcd protein: yggJ fucI isobutanoyl-CoA biosynthetic non-essential [+ 6 isozymes] reductase: fabG [+ 2 isozymes] aspC qor ybjU degradation II glutamate degradation I reductase: S1557 a α-limit dextrin L(or D)-ribulose an N 3 - UMP arginine (4-hydroxyphenyl) phosphatidylglycerophosphate a (6S)-5- β-D-fructose 1,6- (3R,11Z,14Z,17Z)-3- D-glucono- keto-D-psicose decarboxylase a monocarboxylate with short branches an aldehyde 3-sulfopyruvate a semiquinone 5-phosphate estrone methyluracil 1498 decarboxylase: acetate phosphatase: pgpB formyltetrahydrofolate 5-hydroxyindole acetaldehyde bisphosphate hydroxyicosatrienoyl-CoA 1,5-lactone L-glutamine thr isozyme: gadB asp 1-oleoyl-2-palmitoyl- in 16S rRNA speA 4-aminobutanoate (S)-3-hydroxy- degradation II threonine aspartate phosphatidylglycerol biodegradative isobutanoate dehydrogenase: aminotransferase: arginine gln 4-methylphenol tdh aspC decarboxylase: L-2-amino-3- (indol-3-yl) cytidine 2',3'-cyclic uridine 2'3'-cyclic D-ribulose 2'-deoxyuridine cytidine glutamate oxaloacetate starch dihydrolipoamide 4-guanidinobutyramide N-ethylmaleimide (S)-dihydroorotate D-glucopyranose wound RNA cellulose Cu 2+ a cytosine in DNA oxobutanoate monophosphate monophosphate synthase: adiA acetamide 5-phosphate uridine/ agmatine 2:3-cyclic-nucleotide 2:3-cyclic-nucleotide glucose putative DNA thymidine (S)-methylmalonate- gltD gltB 2-amino-3- pyruvate dehydrogenase glutathionylspermidine glutathionylspermidine probable dihydro-orotate putative respiratory NADH cytidine 2-phosphodiesterase: 2-phosphodiesterase: N-ethylmaleimide dehydrogenase: endoglucanase: cytosine kinase: tdk semialdehyde ketobutyrate CoA (dihydrolipoyltransacetylase synthetase/amidase: gsp synthetase/amidase: gsp phosphoribulokinase: dehydrogenase: ATPase: ybaR dehydrogenase: kinase: udk glutamate agmatinase: alpha- cpdB cpdB reductase: nemA component): aceF [+ 5 isozymes] [+ 5 isozymes] prkB pyrD gcd [+ 2 isozymes] yhjM ndh methylase: synthase, speB ligase (glycine amylase: malS dUMP CMP 3'-cmp 3'-UMP D-ribulose-1,5- orotate D-glucono- dcm small acetyltransferase) S-acetyldihydrolipoamide 4-guanidinobutanoate (indol-3-yl)acetate N-ethylsuccinimide a cellodextrin Cu + a 5-methylcytosine bisphosphate 1,5-lactone an unwound RNA subunit: gltD putrescine : kbl in DNA (S)-3-amino-2- glu D-glucopyranose a maltodextrin maltose hydrogencarbonate gly methylpropanoate

arg iron(III)- a bile acid an L- an L- an enterobactin enterobactin galactitol 1- D-fructofuranose glycine glycine L-ornithine sorbose 1- sorbose 1- lys oligopeptide a β- iron(III)- iron(III)- complex iron(III)- iron(III)- thr spermidine spermidine glu glu glu D-serine 2-dehydro- sulfate 1-phosphate phosphate phosphate asp cadaverine phosphate a hexose D-glucose 6- betaine betaine α α Fe 3+ Fe 3+ (4-hydroxyphenyl) spermidine spermidine D-mannitol α arbutin 6- an an thiosulfate his his his his leu leu a methylated ammonium pro pro pro pro pro ammonium glucoside 6- a dicarboxylate a dicarboxylate phosphonate phosphonate phosphonate a nucleoside a nucleoside enterobactin enterobactin enterobactin enterobactin molybdate molybdate molybdate N-acetyl- -D- N-acetyl- -D- ser ser arg arg arg arg arg gln gln glu putrescine putrescine putrescine putrescine putrescine putrescine asp asp asp trp trp lys D-ala 4-aminobutanoate tyr 3-deoxy-D- -D- L-arabinose L-arabinose L-arabinose ferrichrome glu putrescine 1-phosphate D-galactonate a phospholipid a xenobiotic galactoside phosphate phosphate phosphate complex complex complex complex galactosamine galactosamine ferrichrome acetate putrescine gly gluconate a polysaccharide xylopyranose phosphate oligopeptide oligopeptide putative putative ferric predicted predicted predicted putative sodium predicted predicted predicted enterobactin transport ATP-driven ATP-driven transporter arginine/ bile acid transporter transporter transporter putative AmtB ProV ProW ProX ProP ProY CysQ BglF DcuA DcuB PhnC PhnE PhnD NupC NupG AraG AraH AraE FepG FepG transport FepC FepD ModF ModC ModB AgaC AgaV FhuD FhuB HpaX TdcC SdaC ArtM ArtQ ArtJ ArtI ArtP GlnQ GlnP GltL GltS PotD PotA PotE PotB PotC PotG PotI PotH GltP GltJ GltK Mtr TnaB LysP CycA GabP TyrP of lysine/ MtlA DgoT KdgT Wza XylH GlvB OppB OppC transporter EmrK transporter CysU HisQ HisJ HisM HisP LivF LivK MglC UhpT Crr complex ornithine symporter complex of complex of complex of flippase ATP-binding cadaverine complex of an complex of of Fructose antiporter family a sorbose a sorbose GALACTITOL enterobactin protein oligopeptide a methylated a hexose protein iron(III)- iron(III)- iron(III)- iron(III)- N-acetyl-α-D- N-acetyl-α-D- Fe 3+ Fe 3+ (4-hydroxyphenyl) spermidine spermidine D-serine 2-dehydro- α-D- an an D-glucose a β-glucoside phosphonate L-arabinose L-arabinose L-arabinose asp putrescine putrescine D-mannitol D-galactonate arbutin his his his his leu leu galactoside phosphate pro pro pro ammonium a dicarboxylate a dicarboxylate phosphonate phosphonate a nucleoside a nucleoside enterobactin enterobactin enterobactin enterobactin molybdate molybdate molybdate galactosamine galactosamine ser arg arg arg arg arg gln gln glu putrescine putrescine trp trp lys D-ala 4-aminobutanoate tyr 3-deoxy-D- xylopyranose thiosulfate ferrichrome ferrichrome acetate putrescine putrescine putrescine putrescine a polysaccharide oligopeptide oligopeptide pro pro ser glu asp asp asp lys gluconate a phospholipid D-fructofuranose glycine glycine L-sorbose L-sorbose complex complex iron(III)- complex complex gly galactitol an enterobactin sulfate spermidine spermidine cadaverine betaine betaine L-ornithine a bile acid enterobactin thr glu glu glu oligopeptide complex arg ammonium a xenobiotic Copyright © 2014, SRI International. All Rights Reserved. This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.