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Supl Table 1 for Pdf.Xlsx BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any reliance Supplemental material placed on this supplemental material which has been supplied by the author(s) Gut Table S1. Proteomic analysis of liver tissues from 4-months old control and LPTENKO mice. Soluble Fraction Gene names LOG2FC CTL1 LOG2FC CTL2 LOG2FC CTL3 LOG2FC KO1 LOG2FC KO2 LOG2FC KO3 t-test adj Pvalue Aass 0.081686519 -0.097912098 0.016225579 -1.135271836 -0.860535624 -1.263037541 0.0011157 1.206072068 Acsm5 -0.125220746 0.071090866 0.054129881 -0.780692107 -0.882155692 -1.158378647 0.00189031 1.021713016 Gstm2 -0.12707966 0.572554941 -0.445475281 1.952813994 1.856518122 1.561376671 0.00517664 1.865316016 Gstm1 -0.029147714 0.298593425 -0.26944571 0.983159098 0.872028945 0.786125509 0.00721356 1.949464926 Fasn 0.08403202 -0.214149498 0.130117478 1.052480559 0.779734519 1.229308218 0.00383637 0.829422353 Upb1 -0.112438784 -0.137014769 0.249453553 -1.297732445 -1.181999331 -1.495303666 0.00102373 0.184442034 Selenbp2 0.266508271 0.084791964 -0.351300235 -2.040647809 -2.608780781 -2.039865739 0.00107121 0.165425127 Thrsp -0.15001075 0.177999342 -0.027988592 1.54283307 1.603048661 0.927443822 0.00453549 0.612858263 Hyi 0.142635733 -0.183013091 0.040377359 1.325929636 1.119934412 1.181313897 0.00044587 0.053553518 Eci1 -0.119041811 -0.014846366 0.133888177 -0.599970385 -0.555547972 -1.191875541 0.02292305 2.477981171 Aldh1a7 -0.095682449 -0.017781922 0.113464372 0.653424862 0.931724091 1.110750381 0.00356922 0.350756574 Pebp1 -0.06292058 0.376991734 -0.314071154 1.225832242 0.856975185 0.973503805 0.01132979 1.020624864 Plin2 #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! Ech1 -0.078224359 0.262184541 -0.183960182 -1.153349232 -0.69099171 -0.929852871 0.00817258 0.631039776 Gpd1 0.095148469 -0.07637607 -0.0187724 0.586222489 0.388931271 0.676560856 0.00507253 0.365560329 Adhfe1 -0.203685954 0.105800035 0.097885919 -1.725708421 -2.105101586 -1.852370897 0.00023253 0.015710124 Hal -0.079128676 -0.121305179 0.200433855 -0.947374959 -0.296358184 -1.103189637 0.04278134 2.720389684 Dhrs1 -0.374723461 0.200881883 0.173841579 2.732725217 2.213360853 3.249365208 0.00150167 0.090183466 Acadvl 0.19201011 0.073118951 -0.265129061 -1.272203292 -1.128585526 -1.03029561 0.00175052 0.099595562 Cps1 -0.296031431 0.352550271 -0.056518839 -1.291806166 -0.858535493 -1.278269531 0.0084856 0.458646829 Mccc2 -0.17175603 0.290541884 -0.118785854 -1.472093466 -2.124942111 -1.947436728 0.00161773 0.083274417 Aldh1l1 -0.057531317 0.092211522 -0.034680205 -0.386442413 -0.418386659 -0.728183694 0.01252927 0.615642777 Hsd17b4 0.21067669 -0.224870088 0.014193399 0.690587925 0.9241787 0.627970917 0.00847743 0.398438988 Oat -0.129425976 0.476300887 -0.346874911 -1.165166 -1.654257754 -3.23500621 0.03971156 1.788674736 Suox -0.094234118 0.054718159 0.039515959 -0.664305629 -0.595438225 -0.753119559 0.0005194 0.022459022 Keg1 -0.017606832 -0.281514764 0.299121596 -1.02481241 -1.064514186 -0.735281244 0.00883109 0.367169687 Dmgdh -0.069389388 0.047615126 0.021774263 -0.616415736 -0.644981097 -0.681863312 8.70E-05 0.003483167 Fmo5 #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! Pgd -0.041772902 0.214283473 -0.17251057 0.780204764 0.65587459 1.105728044 0.00851955 0.317573666 Decr2 -0.284042627 0.275226632 0.008815994 0.37094675 0.809482318 1.046002017 0.04382664 1.579219982 Hmgcs2 0.120393823 -0.08577386 -0.034619963 -0.447430715 -0.492483572 -0.657846232 0.00393163 0.137099659 Mettl7b -1.257674066 0.737725358 0.519948708 1.487595793 2.0054502 2.394059332 0.04558231 1.539827436 Acaca 0.69174984 -1.112091671 0.420341832 2.293704013 1.967696184 3.217811831 0.0209458 0.686133569 Pcca 0.110383498 0.121633176 -0.232016675 -0.725583114 -0.641053308 -0.695079755 0.00441724 0.140442166 Mccc1 0.259447914 -0.669431553 0.409983639 -2.085010473 -1.064762558 -2.21748095 0.02269451 0.700936075 Ces2a -0.052772803 0.145223105 -0.092450301 -1.194140376 -1.165224304 -1.001107241 0.00029552 0.008873887 Gm4952 0.207949017 -0.056701585 -0.151247432 -0.894185523 -0.723509024 -1.242710243 0.00696358 0.20344943 Srm 0.067771485 0.181553592 -0.249325077 -0.91028052 -1.593368812 -0.617593848 0.0303057 0.862117359 Ces3b -0.01908459 0.169412477 -0.150327886 -2.035430585 -1.851968595 -1.059786129 0.00624749 0.173167627 Pitpnb 0.255832021 -0.109231275 -0.146600746 0.884961351 0.97374999 1.069921178 0.00216738 0.058573356 Lgals1 0.542006427 0.017501859 -0.559508285 3.255566896 2.819064055 1.92383489 0.00616353 0.162506838 Adh4 -0.05003694 0.011657759 0.038379181 -0.428943443 -1.230935612 -1.249723764 0.02340566 0.602417062 D2hgdh #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! Csad 0.032439032 0.598453121 -0.630892153 0.792933316 0.845561572 1.204720337 0.06628954 1.628613475 Dld -0.026043622 0.035080755 -0.009037133 -0.660514755 -0.189315801 -0.990077754 0.05810381 1.395782569 Cyb5r3 -0.094726138 0.01675697 0.077969168 1.360474498 1.130012583 2.104268078 0.00681644 0.160186267 Haao -0.018691989 -0.017969601 0.036661589 -0.388995568 -0.352505274 -0.456738293 0.00036009 0.008282077 Aacs 0.143815986 -0.246176965 0.102360979 0.987136128 1.232242259 0.889952647 0.00294083 0.066229851 Cpq 0.171736479 0.18677116 -0.358507639 -1.112590411 -1.394325112 -1.16579492 0.00354481 0.078202849 Akr1d1 -0.045388319 0.043413877 0.001974442 -0.794213398 -0.231186312 -0.902909506 0.03749236 0.810584914 Pcyt2 0.489113639 -0.124443375 -0.364670264 0.635960263 0.72637907 0.774667756 0.05048003 1.069978764 Ugt1a9;Ugt1a5;Ugt1a8;Ugt1a7c;Ugt1a6;Ugt1a6b;Ugt1a1;Ugt1a6a-0.529524255 0.334103803 0.195420452 1.271750906 0.818396502 1.821710621 0.02984872 0.620508887 Ces2c 0.010097267 0.210166005 -0.220263272 -1.765858478 -1.340249585 -1.390608133 0.00121049 0.024689431 Acsf2 -0.175074289 0.036722401 0.138351888 -0.611654741 -0.62077916 -0.658965309 0.00251649 0.050376383 Dnaja1 -0.608240937 0.787004969 -0.178764032 1.032963823 1.004729533 1.618578889 0.05650858 1.110650355 Mut 0.034408848 0.151126484 -0.185535332 -0.760995763 -0.924577252 -0.650130481 0.00357383 0.068987617 Aldh3a2 0.262022052 -0.370854023 0.108831972 3.006630749 1.894575607 3.744130472 0.00721795 0.136887852 2810007J24Rik 0.222305658 -0.207077908 -0.015227749 -0.681044938 -0.46821896 -0.865282585 0.01651211 0.307751575 Cyb5;Cyb5a 0.43563254 -0.830163373 0.394530833 2.64738102 2.21854455 2.370194688 0.00512316 0.093866698 Ces3a 0.111734198 0.089918003 -0.201652202 -1.244444864 -1.500057708 -0.848367157 0.00507317 0.091401542 Hsd17b13 -0.639346412 -0.072044531 0.711390942 2.411804745 1.600234491 1.903771752 0.01255189 0.222435977 Cth -0.378709166 0.28997083 0.088738336 -1.123378984 -0.588827073 -0.768673936 0.03074195 0.536000783 Pabpc1;Pabpc6 0.305302449 -0.048446528 -0.256855922 -0.535665292 -0.567111054 -0.477721166 0.03383385 0.580545907 Shmt2 0.197156902 -0.084344867 -0.112812035 -0.38602153 -0.215220301 -0.940446214 0.09916255 1.674917384 Ivd -0.034589977 0.016298984 0.018290993 -0.686231469 -0.155800515 -1.434973116 0.11052698 1.838148625 Gpx1 -0.010690815 -0.027804707 0.038495522 -0.269314615 -0.439450628 -0.805486814 0.03398822 0.556685786 Ak2 0.070009083 0.013904829 -0.083913912 -0.460025779 -0.430436813 -0.737330772 0.00726602 0.117232369 Nudc -0.183357219 -0.032194193 0.215551412 0.620787599 1.11325793 0.73055224 0.01223417 0.194487303 Mgst1 #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! Eci2 0.364311698 -0.219081267 -0.145230431 -0.497448387 -0.533091861 -1.164030189 0.0614457 0.948897127 Acaa2 -0.177245968 0.445770634 -0.268524666 -0.628323109 -0.697508909 -0.868502356 0.03602065 0.548427127 Aldob 0.14930603 -0.401712591 0.252406561 0.668270182 0.759589838 0.350302407 0.06740889 1.012069531 Lrpprc -0.065899257 0.305884699 -0.239985442 -1.377569651 -0.901624237 -0.815172263 0.01225479 0.181471539 Uso1 0.470329102 -0.775552593 0.305223491 1.759837586 2.042689834 1.171921058 0.02384135 0.348277067 Acsm1 -0.102141044 0.276751635 -0.174610591 -0.942645565 -1.035537941 -0.755516262 0.0049542 0.071406534 Rdh7 -0.309024753 0.05649426 0.252530494 1.093434156 1.260108071 2.143370242 0.01476722 0.210044222 Hspa9 0.00699463 0.404989579 -0.411984208 -0.803309028 -0.489750682 -0.928073782 0.05152422 0.723346501 Gstt2 -0.1411304 0.059852043 0.081278357 -0.811911803 -0.690279357 -1.254071857 0.0077255 0.107067448 Abat -0.008063364 0.005807126 0.002256238 -1.076936478 -0.905294355 -0.86137834 0.00013577 0.00185774 Pnp 0.021148103 0.125041328 -0.146189431 -0.713145068 -1.181200863 -0.858802802 0.00450091 0.060818559 H6pd 0.219068387 0.099248501 -0.318316887 -1.228574827 -1.499328606 -0.468037612 0.03794584 0.506413027 Hspd1 -0.305113216 0.216108464 0.089004752 -0.515311778 -0.648229168 -0.661466422 0.02054329 0.270820655 Pccb 0.133442088 0.045333287 -0.178775375 -0.82280502 -1.296459959 -0.691656185 0.01040554 0.135522687 Pah -0.339513792 0.297924238 0.041589554 -0.426414344 -0.611923297 -0.730976337 0.04533979 0.583479883 Lhpp -0.015735331 0.179424406 -0.163689075 -1.207577496 -1.265621396 -1.556422014 0.00078965 0.010042456 Gcdh -0.103165222 0.230204792 -0.12703957 -0.701091256 -0.547316317 -0.777343339 0.00722623 0.090831982 Cpt2 -0.049895369 0.118905123 -0.069009754 -0.884168281 -0.735427655 -0.561540515 0.00278183 0.034565027 Sephs2 -0.286437113 0.187354479 0.099082634 -0.966632924 -1.021884155 -0.458742811 0.02414119 0.296552561 Apoe 0.266060435 -0.425709854 0.159649419 1.529388972 1.899180955 1.076946506 0.00941567 0.114363321 Cmah 0.162189036 0.205093155 -0.367282191 -1.529799814
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