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Peptide Toxins Quick Reference Peptide Toxin Series Peptide Toxins Synthetic Ion Channel Blockers for Pain Research Peptides International has increased its portfolio of disulfide rich peptides which have potential therapeutic value, becoming the industry leader in this area. Many of these peptides originate from the venoms of animals such as scor- pions, spiders, snakes, sea anemones and cone snails, in which they act synergistically to immobilize prey or prevent predation. Several interesting drugs actually have originated from venom peptides such as Prialt (ziconotide) for the treatment of chronic intractable pain, which comes from Conus magus, and Integrillin (Eptifibatide), derived from venom from the rattlesnake Sistrurus miliarus barbbouri, which is an anticoagulant peptide. More recently, one of our research programs centered around the sea anemone peptide ShK (dalazatide), originating from Stichodactyla helianthus, for treating autoimmune diseases, has passed a phase 1b clinical trial. Therefore, we are delighted to offer a plethora of new disulfide rich peptides to facilitate your research/drug discovery programs. Our new products include three potassium channel blocking peptides isolated from different scorpion venoms, Iberiotoxin, HsTX-1, and Martentoxin-1; Gurmarin, derived from the plant Gymnema sylvestre, which is a sweet-taste inhibiting peptide; and Tylotoin a wound healing peptide isolated from the skin of the salamander Tylototriton verrucosus. CODE PRODUCT QTY GUR-3810-PI Gurmarin 1 mg Pyr-Gln-Cys-Val-Lys-Lys-Asp-Glu-Leu-Cys-Ile-Pro-Tyr-Tyr-Leu-Asp-Cys-Cys- 5 mg NEW! Glu-Pro-Leu-Glu-Cys-Lys-Lys-Val-Asn-Trp-Trp-Asp-His-Lys-Cys-Ile-Gly-OH (M.W. 4208.95) C187H276N46O53S6 [138464-10-5] J.I. Fletcher, et al., Eur. J. Biochem., 264, 525 (1999). Y. Ninomiya, et al., Am J Physiol., 274, R1324 (1998). M. Sigoillot, et al., Appl. Microbiol. Biotechnol., 96, 619 (2012). A. Shiyovich, et al., Am. J. Med. Sci., 340, 514 (2010). THS-3822-PI HsTX-1 1 mg H-Ala-Ser-Cys-Arg-Thr-Pro-Lys-Asp-Cys-Ala-Asp-Pro-Cys-Arg-Lys-Glu-Thr-Gly- 5 mg NEW! Cys-Pro-Tyr-Gly-Lys-Cys-Met-Asn-Arg-Lys-Cys-Lys-Cys-Asn-Arg-Cys-NH2 (M.W. 3818.53) C149H246N54O46S9 Disulfide bonds between C3-C24, C9-C29, C13-C31, and C19-C34 50 Kv1.3 channel blocker (IC ~ 12pM) PIB-3813-PI Iberiotoxin 1 mg IbTX 5 mg NEW! Pyr-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys- Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH (M.W. 4230.8) C179H274N50O55S7 [129203-60-7] A. Galvez, et al., J. Biol. Chem., 265, 11083 (1990). (Original) K.M. Giangiacomo, et al., Biochemistry, 31, 6719 (1992). (Pharmacol.) M.L. Garcia, et al., J. Bioenerg. Biomembr., 23, 615 (1991). G. J. Kaczorowski, et al., J. Bioenerg. Biomembr., 28, 255 (1996). (Review) (Review) MAR-3811-PI Martentoxin-1 1 mg H-Gly-Leu-Ile-Asp-Val-Lys-Cys-Phe-Ala-Ser-Ser-Glu-Cys-Trp-Thr-Ala-Cys-Lys-Lys-Val-Thr- 5 mg NEW! Gly-Ser-Gly-Gln-Gly-Lys-Cys-Gln-Asn-Asn-Gln-Cys-Arg-Cys-Tyr-OH (M.W. 3911.50) C162H253N49O52S6 Disulfide bonds between Cys8-Cys29, Cys14-Cys34, and Cys18-Cys36 Calcium-activated K+ channel inhibitor J. Tao, et al., PLOS one, 6e, 15896 (2011). J. Shi, et al., Biophy. Journal., 94, 3706 (2008). Y. Ji, et al., J. Neurochem., 84, 325 (2003). Z. Cao, et al., J. Peptides Res., 62, 252 (2003). TYL-3814-PI Tylotoin 1 mg Salamander (Tylototriton verrucosus) 5 mg NEW! H-Lys-(Cys-Val-Arg-Gln-Asn-Asn-Lys-Arg-Val-Cys)-Lys-OH (M.W. 1473.80) C59H108N24O16S2 Potential Wound Healing Peptide, Found in Salamander (Tylototriton verrucosus) Skin. Enhances Keratinocyte, Fibroblast and Vascular Endothelial Cell Proliferation and Migration. Peptides International, Inc. P.O. Box 99703 Phone: 502-266-8787 1-800-777-4779 Louisville, KY 40269-0703 USA Fax: 502-267-1329 E-mail: [email protected] PEPTIDE TOXINS - A QUICK REFERENCE (see back page for channel blockers and gating modifiers) All Peptides International -s and -v products are sold with net peptide weight. Content and solubility data is provided for each lot. CODE COMPOUND QTY CODE COMPOUND QTY PAG-4256-s ω-Agatoxin-IVA 0.1 mg vial PCB-4455-s Huwentoxin-IV 0.1 mg vial NEW! PAG-4294-s ω-Agatoxin TK 0.1 mg vial PIB-4235-s Iberiotoxin (IbTX) 0.1 mg vial PAG-4247-s Agelenin 0.1 mg vial PIM-4343-s Imperatoxin A (IpTXa) 0.1 mg vial PAP-4257-v Apamin 0.5 mg vial PKL-4259-s Kaliotoxin (1-37) 0.1 mg vial PAG-3402-s Biotinyl-ω-Agatoxin IVA 0.1 mg vial PKT-4375-s Kurtoxin 0.1 mg vial NEW! PCC-4310-s Calcicludine 0.1 mg vial MAM-3778-PI Mambalgin-1 0.5 & 1 mg NEW! PCL-4255-s Calciseptine 0.1 mg vial PAR-4290-s Margatoxin (MGTX) 0.1 mg vial PCB-4227-s Charybdotoxin (ChTX) 0.1 mg vial MAR-3811-PI Martentoxin-1 1 & 5 mg NEW! PCN-4282-v Chlorotoxin 0.5 mg vial PMC-4258-v Mast Cell Degranulating Peptide 0.5 mg vial PCN-4126-v α-Conotoxin GI 0.5 mg vial PMS-4107-v Mastoparan 0.5 mg vial PCN-4140-v α-Conotoxin MI 0.5 mg vial PMT-4341-s Muscarinic Toxin 1 (MTX1, MT1) 0.1 mg vial PCN-4311-v α-Conotoxin ImI 0.5 mg vial PMT-4410-s Muscarinic Toxin 3 0.1 mg vial (MT3, MTX3, m4-toxin) PCN-4228-v α-Conotoxin SI 0.5 mg vial PMT-4340-s Muscarinic Toxin 7 (MTX7, MT7) 0.1 mg vial PCN-4263-v µ-Conotoxin GS 0.5 mg vial PNT-4195-s Neurotoxin, NSTX-3 0.1 mg vial PCN-4217-v µ-Conotoxin GIIIB 0.5 mg vial PPL-4300-s PLTX-II 0.1 mg vial PCN-4440-v µ-Conotoxin SIIIA 0.5 mg vial NEW! PTX-4409-s ProTx-I 0.1 mg vial PCN-4161-v ω-Conotoxin GVIA 0.5 mg vial PTX-4450-s ProTx-II 0.1 mg vial PCN-4283-s ω-Conotoxin MVIIC 0.1 mg vial PTX-4435-s Psalmotoxin 1 0.1 mg vial PCN-4283-v ω-Conotoxin MVIIC 0.5 mg vial PSF-4206-s Sarafotoxin S6b 0.1 mg vial PCN-4289-v ω-Conotoxin MVIIA 0.5 mg vial PPT-4457-s Purotoxin-1 0.1 mg vial PCN-4284-v ω-Conotoxin SVIB 0.5 mg vial PSF-4246-s Sarafotoxin S6c 0.1 mg vial PDN-4330-s Dendrotoxin I 0.1 mg vial PCB-4363-s SNX-482 0.1 mg vial ECT-3760-PI Echistatin 1 & 5 mg NEW! PSC-4260-s Scyllatoxin/Leiurotoxin 0.1 mg vial ENT-3744-PI Enterotoxin STp 1 & 5 mg NEW! PSK-4287-s Stichodactyla Toxin 0.1 mg vial SHK-3746-PI 5-Fam-ShK 1 & 5 mg NEW! PTK-4364-s Tertiapin 0.1 mg vial TGX-3862-PI GpTx-1 1 & 5 mg NEW! PTT-4313-s Tityustoxin Kα 0.1 mg vial GUR-3810-PI Gurmarin 1 & 5 mg TYL-3814-PI Tylotoin 1 & 5 mg NEW! PGX-4433-s Guangxitoxin-1E 0.1 mg vial PUG-3772-PI Uroguanylin (Human) 1 & 5 mg NEW! NEW! THS-3822-PI HsTX-1 1 & 5 mg PUG-4295-s Uroguanylin Isomer A (Human) 0.1 mg vial NEW! PUG-4463-s Uroguanylin Isomer B (Human) 0.1 mg vial NEW! PLEASE NOTE: Conotoxin peptides are not available for export without a license from the US Department of Commerce. To place an order for conotoxin peptides to be shipped within the United States please contact Peptides International to obtain important information regarding the CDC Select Agent Transfer Program. Thank you for your cooperation! Some Products of Interest from the Peptide Institute CODE PRODUCT QTY PMT-4410-s Muscarinic Toxin 3 0.1 mg (Green Mamba, Dendroaspis angusticeps) vial MT3, MTX3, m4-toxin Synthetic Product Leu-Thr-Cys-Val-Thr-Lys-Asn-Thr-Ile-Phe-Gly-Ile-Thr-Thr-Glu-Asn-Cys-Pro-Ala-Gly-Gln-Asn-Leu-Cys-Phe-Lys- Arg-Trp-His-Tyr-Val-Ile-Pro-Arg-Tyr-Thr-Glu-Ile-Thr-Arg-Gly-Cys-Ala-Ala-Thr-Cys-Pro-Ile-Pro-Glu-Asn-Tyr-Asp-Ser- Ile-His-Cys-Cys-Lys-Thr-Asp-Lys-Cys-Asn-Glu (Disulfide bonds between Cys3- Cys24, Cys17- Cys42, Cys46- Cys57, and Cys58- Cys63) (M.W. 7379.40 ) C319H489N89O97S8 Specific Ligand for Muscarinic Acetylcholine Receptor-4 (M4) M. Jolkkonen, et al., FEBS Lett., 352, 91 (1994). (Original; MT3) J.-S. Liang, et al., Toxicon, 34, 1257 (1996). (Original; m4-toxin) A. Adem and E. Karlsson, Life Sci., 60, 1069 (1997). (Pharmacol.; Muscarinic Receptor Subtype Specificity) S. Katayama, et al., Peptide Science 2004, 161 (2005). (S-S Bond) PTX-4409-s ProTx-I 0.1 mg vial Synthetic Product (Tarantula, Thrixopelma pruriens) Glu-Cys-Arg-Tyr-Trp-Leu-Gly-Gly-Cys-Ser-Ala-Gly-Gln-Thr-Cys-Cys-Lys-His-Leu-Val-Cys-Ser-Arg-Arg-His-Gly- Trp-Cys-Val-Trp-Asp-Gly-Thr-Phe-Ser (Disulfide bonds between Cys2-Cys16, Cys9-Cys21, and Cys15- Cys28) (M.W. 3987.50 ) C171H245N53O47S6 T-Type Ca2+ Channel / Na+ Channel / K+ Channel Blocker (Gating Modifier) PTX-4450-s ProTx-II 0.1 mg vial Synthetic Product (Tarantula, Thrixopelma pruriens) Tyr-Cys-Gln-Lys-Trp-Met-Trp-Thr-Cys-Asp-Ser-Glu-Arg-Lys-Cys-Cys-Glu-Gly-Met-Val-Cys-Arg-Leu-Trp-Cys-Lys- Lys-Lys-Leu-Trp (Disulfide bonds between Cys2-Cys16, Cys9- Cys21, and Cys15-Cys25) (M.W.
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