DOCSLIB.ORG

The AFIP's Department of Veterinary Pathology & the American Registry of Pathology Dedicate This Pathology of Laboratory A

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
The AFIP's Department of Veterinary Pathology & the American Registry of Pathology Dedicate This Pathology of Laboratory A The AFIP’s Department of Veterinary Pathology & the American Registry of Pathology dedicate this Pathology of Laboratory Animals syllabus to COL (Ret.) William Inskeep II. COL (Ret.) William Inskeep II 10 October 1949 – 2 July 2005 COL Inskeep entered active military service in 1971, with a Reserve Officer Training Corps commission in the US Air Force. He served five years as a Minuteman Missile Launch Officer at Francis E. Warren Air Force Base, Cheyenne, Wyoming. He was a graduate of Colorado State University and entered the US Army Veterinary Corps in June 1980. COL Inskeep was a Diplomate of the American College of Veterinary Pathologists and held the Surgeon General’s “A” Proficiency Designator in the field of Veterinary Pathology. He was also a member of the Order of Military Medical Merit. COL Inskeep had many diversified and challenging assignments as a Veterinary Corps Officer, his most recent being the Chair, Department of Veterinary Pathology, AFIP, 1997-2003. He also served as Veterinary Pathology Consultant to the Army Surgeon General, 2000-2003, as AFIP Deputy Director Army, 1998-2001, and as DoD Liaison Officer to the US Department of Agriculture, 1996-2000. COL Inskeep was a graduate of the Army War College. His military awards include Defense Superior Service Medal, Legion of Merit, Meritorious Service Medal with oak leaf cluster, Joint Service Commendation Medal, Army and Air Force Commendation Medals, and Army Staff Badge. COL Inskeep had many accomplishments over his 28 year military career. However, we will remember him most as a dedicated, enthusiastic mentor and teacher of many residents at the AFIP. We pay tribute to our long-time colleague and friend, and will greatly miss him. 49th Pathology of Laboratory Animals 2 – 5 August 2005 Faculty Disclosure Information At the time of printing this syllabus the following faculty had nothing to disclose: Nancy E. Everds, DVM, DACVP James B. Nold, DVM, PhD, DACVP Martha A. Hanes, DVM, DACVP, DACLAM Jo Lynne Raymond, LTC, VC, USA, DACVP Kenneth S. Latimer, DVM, PhD, DACVP Bruce H. Williams, DVM, DACVP The following faculty member has not yet returned faculty disclosure statements: Steven W. Barthold, DVM, PhD, DACVP Gary B. Baskin, DVM, DACVP, DACLAM Robert B. Moeller, Jr., DVM, DACVP Disclosure of Faculty Financial Affiliations As a provider accredited by the Accreditation Council for Continuing Medical Education, the Department of Medical Education of The Armed Forces Institute of Pathology must insure balance, independence, objectivity and scientific rigor in all its individually sponsored or jointly sponsored educational activities. All faculty participating in a sponsored educational activity are expected to disclose to the activity audience any significant financial interest or other relationship (1) with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services discussed in an educational presentation and (2) with any commercial supporters of the activity (significant financial interest or other relationship can include such things as grants or research support, employee, consultant, major stock holder, member of speakers bureau, etc.). The intent of this disclosure is not to prevent a speaker with a significant financial or other relationship from making a presentation, but rather to provide listeners with information on which they can make their own judgments. It remains for the audience to determine whether the speaker’s interests or relationships may influence the presentation with regard to exposition or conclusion. FACULTY Steven W. Barthold, DVM, PhD, DACVP Center for Comparative Medicine School of Medicine and Veterinary Medicine University of California, Davis, Davis, California Gary B. Baskin, DVM, DACVP, DACLAM Sierra Biomedical A Charles River Company Mandeville, Louisiana Nancy E. Everds, DVM, DACVP DuPont Haskell Laboratory for Health and Environmental Sciences Newark, Delaware Martha A. Hanes, DVM, DACVP, DACLAM Integrated Laboratory Systems Research Triangle Park North Carolina Kenneth S. Latimer, DVM, PhD, DACVP Department of Veterinary Pathology College of Veterinary Medicine University of Georgia Athens, Georgia Robert B. Moeller, Jr, DVM, DACVP California Animal Health and Food Safety Laboratory Tulare, California James B. Nold, DVM, PhD, DACVP Safety Assessment, GlaxoSmithKline Research Triangle Park North Carolina Jo Lynne Raymond, LTC, VC, USA, DACVP US Army Medical Research Institute of Infectious Diseases Fort Detrick, Maryland Bruce H. Williams, DVM, DACVP Department of Telemedicine Armed Forces Institute of Pathology Washington, DC PROGRAM Tuesday, 2 August 2005 7:30 - 8:15AM Registration 8:15 - 8:30 Welcome and Announcements - Dale G. Dunn, COL, VC, USA Chair, Department of Veterinary Pathology 8:30 - 9:30 Diseases of Mice - Dr. Barthold 9:30 - 9:45 BREAK 9:45 -10:45 Diseases of Mice - Dr. Barthold 10:45-11:00 BREAK 11:00-12:00PM Diseases of Mice - Dr. Barthold 12:00 -1:00 LUNCH BREAK 1:00 - 2:00 Diseases of Rats - Dr. Barthold 2:00 - 2:15 BREAK 2:15 - 3:15 Diseases of Ferrets - Dr. Williams 3:15 - 3:30 BREAK 3:30 - 4:30 Diseases of Ferrets Dr. Williams ________________________________ Wednesday, 3 August 2005 8:00 - 9:00AM Clinical Pathology - Dr. Latimer 9:00 - 9:15 BREAK 9:15 -10:15 Clinical Pathology - Dr. Latimer 10:15-10:30 BREAK 10:30-11:30 Clinical Pathology - Dr. Latimer 11:30-12:30PM LUNCH BREAK 12:30 - 1:30 Clinical Pathology - Dr. Everds 1:30 - 1:45 BREAK 1:45 - 2:45 Clinical Pathology - Dr. Everds 2:45 - 3:00 BREAK 3:00 - 4:00 Clinical Pathology - Dr. Everds 6:00 - 8:00 Reception, National Museum of Health and Medicine, AFIP Thursday, 4 August 2005 8:00 - 9:00AM Diseases of Primates - Dr. Baskin 9:00 - 9:15 BREAK 9:15 -10:15 Diseases of Primates - Dr. Baskin 10:15-10:30 BREAK 10:30-11:30 Diseases of Primates - Dr. Baskin 11:30-12:30PM LUNCH BREAK 12:30 - 1:30 Diseases of Hamsters, Guinea Pigs, and Gerbils - Dr. Hanes 1:30 - 1:45 BREAK 1:45 - 2:45 Diseases of Hamsters, Guinea Pigs, and Gerbils - Dr. Hanes 2:45 - 3:00 BREAK 3:00 - 4:00 Diseases of Rabbits - LTC Raymond ________________________________ Friday, 5 August 2005 8:00 - 9:00AM Diseases and Neoplasms of the Aging Rat - Dr. Nold 9:00 - 9:15 BREAK 9:15 -10:15 Diseases and Neoplasms of the Aging Rat - Dr. Nold 10:15-10:30 BREAK 10:30-11:30 Diseases and Neoplasms of the Aging Rat - Dr. Nold 11:30-12:30PM LUNCH BREAK 12:30 - 1:30 Diseases of Fish - Dr. Moeller 1:30 - 1:45 BREAK 1:45 - 2:45 Diseases of Fish - Dr. Moeller 2:45 - 3:00 Closing Remarks - COL Dunn PATHOLOGY OF LABORATORY MICE Stephen W. Barthold, DVM, PhD Professor and Director Center for Comparative Medicine Schools of Medicine and Veterinary Medicine University of California, Davis One Shields Ave. Davis, CA 95616 [email protected] (530) 752-1245 Director UC Davis Mouse Biology Program http://ccm.ucdavis.edu/mbp/ (530) 754-MOUSE [email protected] THE LABORATORY MOUSE Mus musculus sensu lato (Mus domesticus, castaneus, musculus, et al.) Normal features: Social structure: Deme – dominance heirarchy allows mature males to exist within the population (unusual for rodents) Pheromones Physiology: Heterothermic: not quite homeothermic, not quite poikilothermic. Wide adaptive environmental range, but intolerant to sudden temperature variations. Death @ >80 degrees F if sudden. Digestive system: Incisive foramen Continuously growing incisors, rooted molars Gastric yeast (Torulopsis spp.) Simple intestine Sexual dimorphism of submaxillary salivary gland serous cells Paneth cells in crypts - very prominent granules Ileal filamentous bacteria Absorption vacuoles in infant small intestine Physiologic hyperplasia in lactating, pregnant females Very short rectum - descending colon enveloped in serosa almost to anus, thereby making mouse susceptible to rectal prolapse Variable liver lobation Certain strains (BALB) prone to normal background hepatocellular fatty change. Exacerbated in disease. Hepatocellular polykarya, megalokarya (polyploidy) Hepatocellular intranuclear cytoplasmic invagination Giant pancreatic islets Hyalinosis and crystals in biliary and gall bladder epithelium (B6, 129) Respiratory system: Obligate nasal breathers Prominent vomeronasal organs Single left lung lobe, four right lobes. No intrapulmonary bronchi (no cartilage) Cardiac muscle extends around large pulmonary veins Hyalinosis in respiratory, especially nasal epithelium (B6, 129); crystals in lung Hematopoeitic / lymphoid system: Extramedullary hematopoeisis in liver, spleen (sometimes adrenal) in infant mice through weaning age. Continues in spleen throughout life, particularly in pregnancy. Disease states readily induce EMH in liver of adults. No tonsils Thymus does not completely involute Indistinct Hassel’s corpuscles in thymus Ectopic thymus in thyroid, parathyroid and parathyroid in thymus Accessory spleens “Patches” of lymphoid cells on visceral pleura of lung, peritoneum (B1 cells) Mast cells can be common in spleen of some strains (i.e. A) Peyer’s patches in both small and large intestine Short life span of erythrocytes (42 days compared to approx. 100 in humans), resulting in anisocytosis, polychromasia, Howell-Jolly bodies Peripheral blood granulocytosis in adult males “Doughnut” granulocytes, or ring forms especially in tissues Hemosiderin pigment accumulates in spleen, particularly multiparous females Endocrine system: Accessory adrenals common No discernable zona reticularis X zone: basophilic cells surrounding medulla around 10 days of age, then disappear as mice mature. Swollen,
Load more

Recommended publications
  • Plusinside Senti18 Cmufilmfest15
    Pittsburgh Opera stages one of the great war horses 12 PLUSINSIDE SENTI 18 CMU FILM FEST 15 ‘BLOODLINE’ 23 WE-2 +=??B/<C(@ +,B?*(2.)??) & THURSDAY, MARCH 19, 2015 & WWW.POST-GAZETTE.COM Weekend Editor: Scott Mervis How to get listed in the Weekend Guide: Information should be sent to us two weeks prior to publication. [email protected] Send a press release, letter or flier that includes the type of event, date, address, time and phone num- Associate Editor: Karen Carlin ber of venue to: Weekend Guide, Pittsburgh Post-Gazette, 34 Blvd. of the Allies, Pittsburgh 15222. Or fax THE HOT LIST [email protected] to: 412-263-1313. Sorry, we can’t take listings by phone. Email: [email protected] If you cannot send your event two weeks before publication or have late material to submit, you can post Cover design by Dan Marsula your information directly to the Post-Gazette website at http://events.post-gazette.com. » 10 Music » 14 On the Stage » 15 On Film » 18 On the Table » 23 On the Tube Jeff Mattson of Dark Star City Theatre presents the Review of “Master Review of Senti; Munch Rob Owen reviews the new Orchestra gets on board for comedy “Oblivion” by Carly Builder,”opening CMU’s film goes to Circolo. Netflix drama “Bloodline.” the annual D-Jam show. Mensch. festival; festival schedule. ALL WEEKEND SUNDAY Baroque Coffee House Big Trace Johann Sebastian Bach used to spend his Friday evenings Trace Adkins, who has done many a gig opening for Toby at Zimmermann’s Coffee House in Leipzig, Germany, where he Keith, headlines the Palace Theatre in Greensburg Sunday.
    [Show full text]
  • NEW RECORDS on ACANTHOCEPHALANS from CALIFORNIA SEA LIONS ZALOPHUS CALIFORNIANUS (PINNIPEDIA, OTARIIDAE) from CALIFORNIA, USA Fa
    Vestnik Zoologii, 52(3): 181–192, 2018 Fauna and Systematics DOI 10.2478/vzoo-2018-0019 UDC 595.133:599.5(794) NEW RECORDS ON ACANTHOCEPHALANS FROM CALIFORNIA SEA LIONS ZALOPHUS CALIFORNIANUS (PINNIPEDIA, OTARIIDAE) FROM CALIFORNIA, USA O. I. Lisitsyna1, O. Kudlai1- 3, T. R. Spraker4, T. A. Kuzmina1* 1Schmalhausen Institute of Zoology, NAS of Ukraine, vul. B. Khmelnytskogo, 15, Kyiv, 01030 Ukraine 2Institute of Ecology, Nature Research Centre, Akademijos, 2, 08412, Vilnius, Lithuania 3 Water Research Group, Unit for Environmental Sciences and Management, Potchefstroom Campus, North-West University, Potchefstroom 2520, South Africa 4Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, 80526, USA *Corresponding author E-mail [email protected] New Records on Acanthocephalans from California Sea Lions Zalophus californianus (Pinnipedia, Otariidae) from California, USA. Lisitsyna, O. I. Kudlai, O., Spraker, T. R., Kuzmina, T. A. — To increase the currently limited knowledge addressing acanthocephalans parasitizing California sea lions (Zalophus californianus), 33 animals including pups, juvenile and adult males and females from the Marine Mammal Center (TMMC), Sausalito, California, USA were examined. Totally, 2,268 specimens of acanthocephalans representing fi ve species from the genera Andracantha (A. phalacrocoracis and Andracantha sp.), Corynosoma (C. strumosum and C. obtuscens) and Profi licollis (P. altmani) were found. Profi licollis altmani and A. phalacrocoracis, predominantly parasitize fi sh-eating birds; they were registered in Z. californianus for the fi rst time. Prevalence and intensity of California sea lion infection and transmission of acanthocephalans in these hosts of diff erent age groups were analyzed and discussed.
    [Show full text]
  • The Functional Parasitic Worm Secretome: Mapping the Place of Onchocerca Volvulus Excretory Secretory Products
    pathogens Review The Functional Parasitic Worm Secretome: Mapping the Place of Onchocerca volvulus Excretory Secretory Products Luc Vanhamme 1,*, Jacob Souopgui 1 , Stephen Ghogomu 2 and Ferdinand Ngale Njume 1,2 1 Department of Molecular Biology, Institute of Biology and Molecular Medicine, IBMM, Université Libre de Bruxelles, Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium; [email protected] (J.S.); [email protected] (F.N.N.) 2 Molecular and Cell Biology Laboratory, Biotechnology Unit, University of Buea, Buea P.O Box 63, Cameroon; [email protected] * Correspondence: [email protected] Received: 28 October 2020; Accepted: 18 November 2020; Published: 23 November 2020 Abstract: Nematodes constitute a very successful phylum, especially in terms of parasitism. Inside their mammalian hosts, parasitic nematodes mainly dwell in the digestive tract (geohelminths) or in the vascular system (filariae). One of their main characteristics is their long sojourn inside the body where they are accessible to the immune system. Several strategies are used by parasites in order to counteract the immune attacks. One of them is the expression of molecules interfering with the function of the immune system. Excretory-secretory products (ESPs) pertain to this category. This is, however, not their only biological function, as they seem also involved in other mechanisms such as pathogenicity or parasitic cycle (molting, for example). Wewill mainly focus on filariae ESPs with an emphasis on data available regarding Onchocerca volvulus, but we will also refer to a few relevant/illustrative examples related to other worm categories when necessary (geohelminth nematodes, trematodes or cestodes).
    [Show full text]
  • Baylisascariasis
    Baylisascariasis Importance Baylisascaris procyonis, an intestinal nematode of raccoons, can cause severe neurological and ocular signs when its larvae migrate in humans, other mammals and birds. Although clinical cases seem to be rare in people, most reported cases have been Last Updated: December 2013 serious and difficult to treat. Severe disease has also been reported in other mammals and birds. Other species of Baylisascaris, particularly B. melis of European badgers and B. columnaris of skunks, can also cause neural and ocular larva migrans in animals, and are potential human pathogens. Etiology Baylisascariasis is caused by intestinal nematodes (family Ascarididae) in the genus Baylisascaris. The three most pathogenic species are Baylisascaris procyonis, B. melis and B. columnaris. The larvae of these three species can cause extensive damage in intermediate/paratenic hosts: they migrate extensively, continue to grow considerably within these hosts, and sometimes invade the CNS or the eye. Their larvae are very similar in appearance, which can make it very difficult to identify the causative agent in some clinical cases. Other species of Baylisascaris including B. transfuga, B. devos, B. schroeder and B. tasmaniensis may also cause larva migrans. In general, the latter organisms are smaller and tend to invade the muscles, intestines and mesentery; however, B. transfuga has been shown to cause ocular and neural larva migrans in some animals. Species Affected Raccoons (Procyon lotor) are usually the definitive hosts for B. procyonis. Other species known to serve as definitive hosts include dogs (which can be both definitive and intermediate hosts) and kinkajous. Coatimundis and ringtails, which are closely related to kinkajous, might also be able to harbor B.
    [Show full text]
  • Worksafe Bulletin Avian Influenza
    Work Sa fe Bu l l e t in Avian influenza — Protect against infection and prevent the virus from spreading According to the BC Centre for Disease Control, avian influenza (flu) has been transmitted in rare cases from birds to humans and from humans to humans. Because of this possible health risk, it is important to protect humans against exposure to avian flu. What is avian influenza? An outbreak will also require the use of safe work procedures and personal protective equipment Avian flu is a viral disease that affects poultry (PPE), including respiratory protection for workers. and, in some cases, humans. There are several strains of avian flu, which are closely related to It is very important that no birds or materials human influenza. be taken from suspected infection areas. All materials, equipment, and people coming out of such areas must be decontaminated. Do not enter What if an outbreak occurs contaminated areas, if possible. If you must enter, on my farm? follow the direction of CFIA. If you suspect a bird in your flock is infected with avian flu, you must take immediate action. How can I protect myself and others Every farm in British Columbia is required to follow during an outbreak? the BC Poultry Biosecurity Reference Guide. Implement your SOP for self-quarantine, use This document describes mandatory biosecurity enhanced PPE, and follow instructions from CFIA protocols, including how to develop a standard and the Fraser Health Authority. Review these operating procedure (SOP) for self-quarantine. items with your workers and make sure they have Make sure everyone follows your enhanced any necessary training.
    [Show full text]
  • Guide for Common Viral Diseases of Animals in Louisiana
    Sampling and Testing Guide for Common Viral Diseases of Animals in Louisiana Please click on the species of interest: Cattle Deer and Small Ruminants The Louisiana Animal Swine Disease Diagnostic Horses Laboratory Dogs A service unit of the LSU School of Veterinary Medicine Adapted from Murphy, F.A., et al, Veterinary Virology, 3rd ed. Cats Academic Press, 1999. Compiled by Rob Poston Multi-species: Rabiesvirus DCN LADDL Guide for Common Viral Diseases v. B2 1 Cattle Please click on the principle system involvement Generalized viral diseases Respiratory viral diseases Enteric viral diseases Reproductive/neonatal viral diseases Viral infections affecting the skin Back to the Beginning DCN LADDL Guide for Common Viral Diseases v. B2 2 Deer and Small Ruminants Please click on the principle system involvement Generalized viral disease Respiratory viral disease Enteric viral diseases Reproductive/neonatal viral diseases Viral infections affecting the skin Back to the Beginning DCN LADDL Guide for Common Viral Diseases v. B2 3 Swine Please click on the principle system involvement Generalized viral diseases Respiratory viral diseases Enteric viral diseases Reproductive/neonatal viral diseases Viral infections affecting the skin Back to the Beginning DCN LADDL Guide for Common Viral Diseases v. B2 4 Horses Please click on the principle system involvement Generalized viral diseases Neurological viral diseases Respiratory viral diseases Enteric viral diseases Abortifacient/neonatal viral diseases Viral infections affecting the skin Back to the Beginning DCN LADDL Guide for Common Viral Diseases v. B2 5 Dogs Please click on the principle system involvement Generalized viral diseases Respiratory viral diseases Enteric viral diseases Reproductive/neonatal viral diseases Back to the Beginning DCN LADDL Guide for Common Viral Diseases v.
    [Show full text]
  • UNITED STATES DISTRICT COURT NORTHERN DISTRICT of INDIANA SOUTH BEND DIVISION in Re FEDEX GROUND PACKAGE SYSTEM, INC., EMPLOYMEN
    USDC IN/ND case 3:05-md-00527-RLM-MGG document 3279 filed 03/22/19 page 1 of 354 UNITED STATES DISTRICT COURT NORTHERN DISTRICT OF INDIANA SOUTH BEND DIVISION ) Case No. 3:05-MD-527 RLM In re FEDEX GROUND PACKAGE ) (MDL 1700) SYSTEM, INC., EMPLOYMENT ) PRACTICES LITIGATION ) ) ) THIS DOCUMENT RELATES TO: ) ) Carlene Craig, et. al. v. FedEx Case No. 3:05-cv-530 RLM ) Ground Package Systems, Inc., ) ) PROPOSED FINAL APPROVAL ORDER This matter came before the Court for hearing on March 11, 2019, to consider final approval of the proposed ERISA Class Action Settlement reached by and between Plaintiffs Leo Rittenhouse, Jeff Bramlage, Lawrence Liable, Kent Whistler, Mike Moore, Keith Berry, Matthew Cook, Heidi Law, Sylvia O’Brien, Neal Bergkamp, and Dominic Lupo1 (collectively, “the Named Plaintiffs”), on behalf of themselves and the Certified Class, and Defendant FedEx Ground Package System, Inc. (“FXG”) (collectively, “the Parties”), the terms of which Settlement are set forth in the Class Action Settlement Agreement (the “Settlement Agreement”) attached as Exhibit A to the Joint Declaration of Co-Lead Counsel in support of Preliminary Approval of the Kansas Class Action 1 Carlene Craig withdrew as a Named Plaintiff on November 29, 2006. See MDL Doc. No. 409. Named Plaintiffs Ronald Perry and Alan Pacheco are not movants for final approval and filed an objection [MDL Doc. Nos. 3251/3261]. USDC IN/ND case 3:05-md-00527-RLM-MGG document 3279 filed 03/22/19 page 2 of 354 Settlement [MDL Doc. No. 3154-1]. Also before the Court is ERISA Plaintiffs’ Unopposed Motion for Attorney’s Fees and for Payment of Service Awards to the Named Plaintiffs, filed with the Court on October 19, 2018 [MDL Doc.
    [Show full text]
  • Viral Diversity Among Different Bat Species That Share a Common Habitatᰔ Eric F
    JOURNAL OF VIROLOGY, Dec. 2010, p. 13004–13018 Vol. 84, No. 24 0022-538X/10/$12.00 doi:10.1128/JVI.01255-10 Copyright © 2010, American Society for Microbiology. All Rights Reserved. Metagenomic Analysis of the Viromes of Three North American Bat Species: Viral Diversity among Different Bat Species That Share a Common Habitatᰔ Eric F. Donaldson,1†* Aimee N. Haskew,2 J. Edward Gates,2† Jeremy Huynh,1 Clea J. Moore,3 and Matthew B. Frieman4† Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 275991; University of Maryland Center for Environmental Science, Appalachian Laboratory, Frostburg, Maryland 215322; Department of Biological Sciences, Oakwood University, Huntsville, Alabama 358963; and Department of Microbiology and Immunology, University of Maryland at Baltimore, Baltimore, Maryland 212014 Received 11 June 2010/Accepted 24 September 2010 Effective prediction of future viral zoonoses requires an in-depth understanding of the heterologous viral population in key animal species that will likely serve as reservoir hosts or intermediates during the next viral epidemic. The importance of bats as natural hosts for several important viral zoonoses, including Ebola, Marburg, Nipah, Hendra, and rabies viruses and severe acute respiratory syndrome-coronavirus (SARS-CoV), has been established; however, the large viral population diversity (virome) of bats has been partially deter- mined for only a few of the ϳ1,200 bat species. To assess the virome of North American bats, we collected fecal, oral, urine, and tissue samples from individual bats captured at an abandoned railroad tunnel in Maryland that is cohabitated by 7 to 10 different bat species. Here, we present preliminary characterization of the virome of three common North American bat species, including big brown bats (Eptesicus fuscus), tricolored bats (Perimyotis subflavus), and little brown myotis (Myotis lucifugus).
    [Show full text]
  • The Highly Pathogenic Avian Influenza A(H5N1) Virus: a Twenty-Year Journey of Narratives and (In)Secure Landscapes
    The Highly Pathogenic Avian Influenza A(H5N1) Virus: a twenty-year journey of narratives and (in)secure landscapes Philip Rolly Egert Dissertation submitted to the faculty of the Virginia Polytechnic Institute and State University in partial fulfillment of the requirements for the degree of Doctor of Philosophy In Science, Technology, and Society Barbara L. Allen (Chair) Daniel Breslau Bernice L. Hausman David C. Tomblin March 18, 2016 Falls Church, Virginia Keywords: H5N1, HPAI, highly pathogenic avian influenza virus, pandemic, social justice, bioterrorism, bioethics, biopower, tacit knowledge, dual-use dilemma, dual-use research of concern, emerging infectious disease Copyright Philip R. Egert The Highly Pathogenic Avian Influenza A(H5N1) Virus: a twenty-year journey of narratives and (in)secure landscapes Philip Rolly Egert ABSTRACT This dissertation is comprised of two manuscripts that explore various contestations and representations of knowledge about the highly pathogenic avian influenza H5N1virus. In the first manuscript, I explore three narratives that have been produced to describe the 20-year journey of the virus. The journey begins in 1996 when the virus was a singular localized animal virus but then over the next 20 years multiplied its ontological status through a (de)stabilized global network of science and politics that promoted both fears of contagion and politics of otherness. Written by and for powerful actors and institutions in the global North, the narratives focused on technical solutions and outbreak fears. In doing so, the narratives produced policies and practices of biopower that obscured alternative considerations for equity, social justice, and wellbeing for the marginalized groups most directly affected by the H5N1 virus.
    [Show full text]
  • Diagnostic Approach to Congenital Cystic Masses of the Neck from a Clinical and Pathological Perspective
    Review Diagnostic Approach to Congenital Cystic Masses of the Neck from a Clinical and Pathological Perspective Amanda Fanous 1,†, Guillaume Morcrette 2,†, Monique Fabre 3, Vincent Couloigner 1,4 and Louise Galmiche-Rolland 5,* 1 Pediatric Otolaryngology-Head and Neck Surgery, AP-HP, Hôpital Universitaire Necker Enfants Malades, 75015 Paris, France; [email protected] (A.F.); [email protected] (V.C.) 2 Department of Pediatric Pathology, AP-HP, Hôpital Robert Debré, 75019 Paris, France; [email protected] 3 Department of Pathology, AP-HP, Hôpital Universitaire Necker Enfants Malades, Université Paris Descartes, 75015 Paris, France; [email protected] 4 Faculté de Médecine, Université de Paris, 75015 Paris, France 5 Department of Pathology, University Hospital of Nantes, 44000 Nantes, France * Correspondence: [email protected] † These authors contributed equally to this work. Abstract: Background: neck cysts are frequently encountered in pediatric medicine and can present a diagnostic dilemma for clinicians and pathologists. Several clinical items enable to subclassify neck cyst as age at presentation, anatomical location, including compartments and fascia of the neck, and radiological presentation. Summary: this review will briefly describe the clinical, imaging, pathologi- cal and management features of (I) congenital and developmental pathologies, including thyroglossal duct cyst, branchial cleft cysts, dermoid cyst, thymic cyst, and ectopic thymus; (II) vascular malforma- Citation: Fanous, A.; Morcrette, G.; Fabre, M.; Couloigner, V.; tions, including lymphangioma. Key Messages: pathologists should be familiar with the diagnostic Galmiche-Rolland, L. Diagnostic features and clinicopathologic entities of these neck lesions in order to correctly diagnose them and Approach to Congenital Cystic to provide proper clinical management.
    [Show full text]
  • February 15, 2012 Chapter 34 Notes: Flatworms, Roundworms and Rotifers
    February 15, 2012 Chapter 34 Notes: Flatworms, Roundworms and Rotifers Section 1 Platyhelminthes Section 2 Nematoda and Rotifera 34-1 Objectives Summarize the distinguishing characteristics of flatworms. Describe the anatomy of a planarian. Compare free-living and parasitic flatworms. Diagram the life cycle of a fluke. Describe the life cycle of a tapeworm. Structure and Function of Flatworms · The phylum Platyhelminthes includes organisms called flatworms. · They are more complex than sponges but are the simplest animals with bilateral symmetry. · Their bodies develop from three germ layers: · ectoderm · mesoderm · endoderm · They are acoelomates with dorsoventrally flattened bodies. · They exhibit cephalization. · The classification of Platyhelminthes has undergone many recent changes. Characteristics of Flatworms February 15, 2012 Class Turbellaria · The majority of species in the class Turbellaria live in the ocean. · The most familiar turbellarians are the freshwater planarians of the genus Dugesia. · Planarians have a spade-shaped anterior end and a tapered posterior end. Class Turbellaria Continued Digestion and Excretion in Planarians · Planarians feed on decaying plant or animal matter and smaller organisms. · Food is ingested through the pharynx. · Planarians eliminate excess water through a network of excretory tubules. · Each tubule is connected to several flame cells. · The water is transported through the tubules and excreted from pores on the body surface. Class Turbellaria Continued Neural Control in Planarians · The planarian nervous system is more complex than the nerve net of cnidarians. · The cerebral ganglia serve as a simple brain. · A planarian’s nervous system gives it the ability to learn. · Planarians sense light with eyespots. · Other sensory cells respond to touch, water currents, and chemicals in the environment.
    [Show full text]
  • Gypsum in California
    TN 2.4 C3 A3 i<o3 HK STATE OP CAlIFOa!lTA DEPARTMENT OF NATURAL RESOURCES msmtBmmmmmmmmmaam GYPSUM IN CALIFORNIA BULLETIN 163 1952 aou DIVl^ON OF MNES fZBar SDODSia sxh lasncisco ^"^^^^^nBM^^MMa^HBi«iaMa«NnMaMHBaaHB^HaHaa^^HHMi«nfl^HaMHiBHHHMauuHJin««aHiav^aMaHHaHHB«auKaiaMi^^M«ni^Maai^iMMWi^iM^ THE LIBRARY OF THE UNIVERSITY OF CALIFORNIA DAVIS STATE OF CALIFORNIA EARL WARREN, Governor DEPARTMENT OF NATURAL RESOURCES WARREN T. HANNUM, Director DIVISION OF MINES FERRY BUILDING, SAN FRANCISCO 11 OLAF P. JENKINS, Chief San Francisco BULLETIN 163 September 1952 GYPSUM IN CALIFORNIA By WILLIAM E. VER PLANCK LIBRARY UNTXERollY OF CAUFC^NIA DAVIS LETTER OF TRANSMITTAL To IIlS EXCELLKNCY, TlIK IIONORAHLE EauL AVaRREN Governor of the State of California Dear Sir: I have the lionor to transmit herewitli liuUetiii 163, Gyj)- sinn in California, prepared under tlie direetion of Ohif P. Jenkins, Chief of the Division of ]\Iines. Gypsum represents one of the important non- metallic mineral commodities of California. It serves particularly two of California's most important industries, aprieulture and construction. In Bulletin 163 the author, W. p]. Xev Phinek, a member of the staff of the Division of Mines, has prepared a comprehensive treatise cover- ing all phases of the subject : history of the industry, geologic occurrence and origin of tlie minoi-al, mining, i)rocessing and marketing of the com- modity. Specific g3'psum i)roperties Avere examined and mapped. The report is profusely illustrated by maps, charts and photographs. In the preparation of the report it was necessary for the author to make field investigations, laboratory and library studies, and to determine how the mineral is used in industry as Avell as how it occurs in nature and how it is mined.
    [Show full text]