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(12) United States Patent (10) Patent No.: US 8,227,427 B2 Coracci Neto Et Al
USOO8227427B2 (12) United States Patent (10) Patent No.: US 8,227,427 B2 Coracci Neto et al. (45) Date of Patent: Jul. 24, 2012 (54) VETERINARIAN COMPOSITION (52) US. Cl. ........................................ .. 514/27; 514/368 COMPRISING AN ORGANIC SALT 0F (58) Field of Classi?cation Search ................. .. 513/71; LEVAMISOLE IN COMBINATION WITH AT 548/155; 514/27, 368 LEAST ONE AVERMECTIN AND/OR See application ?le for complete search history. MILBEMYCIN (75) Inventors: Dolivar Coracci Neto, Sertaozinho (56) References Cited (BR); Nelson Henriques Fernandes Filho, Jaboticabal (BR); Ricardo da FOREIGN PATENT DOCUMENTS Silva Sercheli, Jaboticabal (BR) BR PI0505716 A 9/2007 GB 2150024 A 6/1985 (73) Assignee: NPA—Nucleo de Pesquisas Aplicadas WO 00/74489 A1 12/2000 Ltda., Jaboticabal (BR) WO 2004/009080 A1 1/2004 OTHER PUBLICATIONS ( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 International Search Report. U.S.C. 154(b) by 575 days. Analytical Report Characterization of Pharmaceutical Input Aurixazol (Feb. 20, 2010). (21) App1.No.: 12/097,683 Primary Examiner * Elli Peselev (22) PCT Filed: Dec. 18, 2006 (74) Attorney, Agent, or Firm * Laurence P. Colton; Smith Risley Tempel Santos LLC (86) PCT No.: PCT/BR2006/000282 § 371 (0X1)’ (57) ABSTRACT (2), (4) Date: Nov. 3, 2008 Veterinarian composition comprising an organic salt of (87) PCT Pub. No.: WO2007/068073 levamisole in combination With at least one avermectin and/ or milbemycin. A veterinarian formulation comprising of organ PCT Pub. Date: Jun. 21, 2007 ics salts of levamisole, more speci?cally to the levamisole salt of 2,6-diiodo-4-nitrophenol and the levamisole salt of 4-hy (65) Prior Publication Data droxy-3-iodo-5-nitrobenzonitrile With avermectins and mil US 2009/0075918 A1 Mar. -
Comparative Efficacies of Commercially Available Benzimidazoles Against Pseudodactylogyrus Infestations in Eels
DISEASES OF AQUATIC ORGANISMS Published October 4 Dis. aquat. Org. l Comparative efficacies of commercially available benzimidazoles against Pseudodactylogyrus infestations in eels ' Department of Fish Diseases, Royal Veterinary and Agricultural University, 13 Biilowsvej, DK-1870 Frederiksberg C, Denmark Department of Pharmacy, Royal Veterinary and Agricultural University, 13 Biilowsvej. DK-1870 Frederiksberg C,Denmark ABSTRACT: The antiparasitic efficacies of 9 benzimidazoles in commercially avalable formulations were tested (water bath treatments) on small pigmented eels Anguilla anguilla, expenmentally infected by 30 to 140 specimens of Pseudodactylogyrus spp. (Monogenea).Exposure time was 24 h and eels were examined 4 to 5 d post treatment. Mebendazole (Vermox; 1 mg 1-') eradicated all parasites, whereas luxabendazole (pure substance) and albendazole (Valbazen) were 100 % effective only at a concen- tration of 10 mg I-'. Flubendazole (Flubenol), fenbendazole (Panacur) and oxibendazole (Lodltac) (10 mg l-') caused a reduction of the infection level to a larger extent than did triclabendazole (Fasinex) and parbendazole (Helmatac).Thiabendazole (Equizole), even at a concentration as high as 100 mg l-', was without effect on Pseudodactylogyrus spp. INTRODUCTION range of commercially available benzimidazole com- pounds. If drug resistance will develop under practical The broad spectrum anthelmintic drug mebendazoIe eel-farm conditions in the future, it is likely to be was reported as an efficacious compound against infes- recognized during treatments with commercially avail- tations of the European eel Anguilla anguilla with gill able drug formulations. Therefore this type of drug parasitic monogeneans of the genus Pseudodactylo- preparations were used in the present study. gyms (Szekely & Molnar 1987, Buchmann & Bjerre- gaard 1989, 1990, Mellergaard 1989). -
Bulletin Leading the Fight Against Heartworm Disease
BULLETIN LEADING THE FIGHT AGAINST HEARTWORM DISEASE SEPTEMBER HEARTWORM 2017 Q&A VOLUME 44 No. 3 Heartworm History: In What Year Was Heartworm First INSIDE THIS ISSUE Treated? Page 4 From the President Page 8 Research Update Abstracts from the Literature Page 14 Heartworm Hotline: Role of Heat Treatment in Diagnostics Page 19 NEW! Best Practices: Minimizing Heartworm Transmission in Relocated Dogs uestions from members, prac- published in the 1998 AHS Symposium 1 titioners, technicians, and the Proceedings. Dr. Roncalli wrote, “The Page 21 Qgeneral public are often submit- first trial to assess the efficacy of a Welcome Our New AHS ted to the American Heartworm Society microfilaricide (natrium antimonyl tar- Student Liaisons (AHS) via our website. Two of our AHS trate) was conducted some 70 years Board members, Dr. John W.McCall and ago (1927) in Japan by S. Itagaki and R. Page 25 Dr. Tom Nelson, provided the resources Makino.2 Fuadin (stibophen), a trivalent In the News: Surgeons to answer this question: In What Year antimony compound, was tested, intra- Remove a Heartworm from Was Heartworm First Treated? venously, as a microfilaricide by Popescu the Femoral Artery of a Cat The first efforts to treat canine heart- in 1933 in Romania and by W.H. Wright worm disease date back to the 1920s. Dr. and P.C. Underwood in 1934 in the USA. Page 26 Nelson referenced a review article by Dr. In 1949, I.C. Mark evaluated its use Quarterly Update Raffaele Roncalli, “Tracing the History of intraperitoneally.” What’s New From AHS? Heartworms: A 400 Year Perspective,” Continues on page 7 American Heartworm Society / PO Box 8266, Wilmington, DE 19803-8266 Become an American Heartworm Society www.heartwormsociety.org / [email protected] fan on Facebook! Follow us on Twitter! OUR GENEROUS SPONSORS PLATINUM LEVEL PO Box 8266 Wilmington, DE 19803-8266 [email protected] www.heartwormsociety.org Mission Statement The mission of the American Heartworm Society is to lead the vet- erinary profession and the public in the understanding of heartworm disease. -
Top Papers in Neglected Tropical Diseases Diagnosis
Top papers in Neglected Tropical Diseases Diagnosis Professor Peter L Chiodini ESCMID eLibrary © by author Neglected tropical diseases http://www.who.int/neglected_diseases/diseases/en/ Accessed 9th April 2017 • Buruli ulcer • Lymphatic filariasis • Chagas disease • Mycetoma • Dengue and Chikungunya • Onchocerciasis • Dracunculiasis • Rabies • Echinococcosis • Schistosomiasis • Foodborne • Soil-transmitted trematodiases helminthiases • Human African • Taeniasis/Cysticercosis trypanosomiasis • Trachoma • Leishmaniasis • Yaws • ESCMIDLeprosy eLibrary © by author PLOS Neglected Tropical Diseases http://journals.plos.org/plosntds/s/journal-information#loc-scope Accessed 9th April 2017 The “big three” diseases, HIV/AIDS, malaria, and tuberculosis, are not generally considered for PLOS Neglected Tropical Diseases. Plasmodium vivax possibly ESCMID eLibrary © by author Flynn, FV (1985) “As is your pathology, so is your practice” ESCMID eLibrary © by author Time for a Model List of Essential Diagnostics Schroeder LF et al. NEJM 2016; 374: 2511 ESCMID eLibrary © by author Peruvian Leishmania: braziliensis or mexicana? ESCMID eLibrary © by author Leishmania (Viannia) from Peru ESCMID eLibrary © by author Karimkhani C et al. Lancet Infect Dis 2016; 16: 584-591 • Global Burden of Disease Study “Unlike the incidence of most other neglected tropical diseases, the incidence of cutaneous leishmaniasis is increasing” ESCMID eLibrary © by author Karimkhani C et al. Lancet Infect Dis 2016; 16: 584-591 ESCMID eLibrary © by author Akhoundi M et al. Molecular Aspects of Medicine (2017) doi: 10.1016/ j.mam.2016.11.012. ESCMID eLibrary © by author Akhoundi M et al. Molecular Aspects of Medicine (2017) doi: 10.1016/ j.mam.2016.11.012. ESCMID eLibrary © by author Akhoundi M et al. Molecular Aspects of Medicine (2017) doi: 10.1016/ j.mam.2016.11.012. -
Integrating Black Bear Behavior, Spatial Ecology, and Population Dynamics in a Human-Dominated Landscape: Implications for Management
Utah State University DigitalCommons@USU All Graduate Theses and Dissertations Graduate Studies 8-2017 Integrating Black Bear Behavior, Spatial Ecology, and Population Dynamics in a Human-Dominated Landscape: Implications for Management Jarod D. Raithel Utah State University Follow this and additional works at: https://digitalcommons.usu.edu/etd Part of the Ecology and Evolutionary Biology Commons Recommended Citation Raithel, Jarod D., "Integrating Black Bear Behavior, Spatial Ecology, and Population Dynamics in a Human- Dominated Landscape: Implications for Management" (2017). All Graduate Theses and Dissertations. 6633. https://digitalcommons.usu.edu/etd/6633 This Dissertation is brought to you for free and open access by the Graduate Studies at DigitalCommons@USU. It has been accepted for inclusion in All Graduate Theses and Dissertations by an authorized administrator of DigitalCommons@USU. For more information, please contact [email protected]. INTEGRATING BLACK BEAR BEHAVIOR, SPATIAL ECOLOGY, AND POPULATION DYNAMICS IN A HUMAN-DOMINATED LANDSCAPE: IMPLICATIONS FOR MANAGEMENT by Jarod D. Raithel A dissertation submitted in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY in Ecology Approved: _______________________ _______________________ Lise M. Aubry, Ph.D. Melissa J. Reynolds-Hogland, Ph.D. Major Professor Committee Member _______________________ _______________________ David N. Koons, Ph.D. Eric M. Gese, Ph.D. Committee Member Committee Member _______________________ _______________________ Joseph M. Wheaton, Ph.D. Mark R. McLellan, Ph.D. Committee Member Vice President for Research and Dean of the School of Graduate Studies UTAH STATE UNIVERSITY Logan, Utah 2017 ii Copyright Jarod Raithel 2017 All Rights Reserved iii ABSTRACT Integrating Black Bear Behavior, Spatial Ecology, and Population Dynamics in a Human-Dominated Landscape: Implications for Management by Jarod D. -
Mebendazole 1
The European Agency for the Evaluation of Medicinal Products Veterinary Medicines Evaluation Unit EMEA/MRL/625/99-FINAL July 1999 COMMITTEE FOR VETERINARY MEDICINAL PRODUCTS MEBENDAZOLE SUMMARY REPORT (1) 1. Mebendazole is a benzimidazole anthelmintic which is used in both human and veterinary medicine. In veterinary medicine, it is administered orally to horses, at a target dose of 8.8 mg/kg bw and to sheep and goats at a target dose of 15 mg/kg bw. Mebendazole has also been used in game birds, pigs, deer, poultry and cattle, including lactating animals and laying birds, but these uses were not supported with regard to the establishment of MRLs. Mebendazole is authorised in a range of mono-preparations including premixes for medicated feed, pastes, tablets, liquids, granules, drenches and suspensions for oral administration. Mebendazole is also used in combination products additionally containing either metrifonate, closantel or minerals (selenium, cobalt). 2. The pharmacokinetics of mebendazole was studied in rats, mice, dogs, humans and several target species. In rats given oral doses in the range of 0.06 to 10 mg/kg bw 14C-mebendazole, most of the radioactivity was recovered from the organs of the gastrointestinal tract and consisted mostly of unmetabolised mebendazole. Less than 1% of the administered radioactivity was detected in blood. Excretion was predominantly via the faeces, with 70 to 90% of the faecal radioactivity consisting of unmetabolised mebendazole. In rat liver, 1 hour after administration, 15% of the radioactivity consisted of unmetabolised mebendazole. Four hours after administration, the percentage of mebendazole had declined to 1%. Absorption in humans was increased when the same dose was given with a meal. -
Phylogeographic and Diversification Patterns of the White-Nosed Coati
Molecular Phylogenetics and Evolution 131 (2019) 149–163 Contents lists available at ScienceDirect Molecular Phylogenetics and Evolution journal homepage: www.elsevier.com/locate/ympev Phylogeographic and diversification patterns of the white-nosed coati (Nasua narica): Evidence for south-to-north colonization of North America T ⁎ Sergio F. Nigenda-Moralesa, , Matthew E. Gompperb, David Valenzuela-Galvánc, Anna R. Layd, Karen M. Kapheime, Christine Hassf, Susan D. Booth-Binczikg, Gerald A. Binczikh, Ben T. Hirschi, Maureen McColginj, John L. Koprowskik, Katherine McFaddenl,1, Robert K. Waynea, ⁎ Klaus-Peter Koepflim,n, a Department of Ecology & Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA b School of Natural Resources, University of Missouri, Columbia, MO 65211, USA c Departamento de Ecología Evolutiva, Centro de Investigación en Biodiversidad y Conservación, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos 62209, Mexico d Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA e Department of Biology, Utah State University, Logan, UT 84322, USA f Wild Mountain Echoes, Vail, AZ 85641, USA g New York State Department of Environmental Conservation, Albany, NY 12233, USA h Amsterdam, New York 12010, USA i Zoology and Ecology, College of Science and Engineering, James Cook University, Townsville, QLD 4811, Australia j Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA k School of Natural Resources and the Environment, The University of Arizona, Tucson, AZ 85721, USA l College of Agriculture, Forestry and Life Sciences, Clemson University, Clemson, SC 29634, USA m Smithsonian Conservation Biology Institute, National Zoological Park, Washington, D.C. -
Hybrid Ascaris Suum/Lumbricoides (Ascarididae) Infestation in a Pig
Cent Eur J Public Health 2013; 21 (4): 224–226 HYBRID ASCARIS SUUM/LUMBRICOIDES (ASCARIDIDAE) INFESTATION IN A PIG FARMER: A RARE CASE OF ZOONOTIC ASCARIASIS Moreno Dutto1, Nicola Petrosillo2 1Department of Prevention, Local Health Unit, ASL CN1, Saluzzo (CN), Italy 2National Institute for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy SUMMARY We present a case of the 42 year old pig farmer from the province of Cuneo in Northwest Italy who was infected by the soil-transmitted nema- tode Ascaris sp. In November 2010 the patient found one worm in his stool, subsequently identified as female specimen of Ascaris sp. After a first anthelmintic treatment, another worm was found in his stool, that was later identified as male Ascaris sp. Blood tests prescribed by the patient’s family physician, as suggested by a parasitologist, found nothing abnormal. A chest x-ray was negative for Loeffler’s syndrome and an ultrasound of the abdomen was normal with no evidence of hepatic problems. The nematode collected from the patient was genetically characterized using the ribosomal nuclear marker ITS. The PCR-RFLP analysis showed a hybrid genotype, intermediate between A. suum/lumbricoides. It was subsequently ascertained that some pigs on the patient’s farm had A. suum infection; no other family member was infected. A cross- infestation from the pigs as source was the likely way of transmission. This conclusion is further warranted by the fact, that the patient is a confirmed nail-biter, a habit which facilitates oral-fecal transmission of parasites and pathogens. Key words: ascariasis, Ascaris suum, cross infection, pigs, zoonosis, hybrid genotype Address for correspondence: M. -
Mammalia, Carnivora) from the Blancan of Florida
THREE NEW PROCYONIDS (MAMMALIA, CARNIVORA) FROM THE BLANCAN OF FLORIDA Laura G. Emmert1,2 and Rachel A. Short1,3 ABSTRACT Fossils of the mammalian family Procyonidae are relatively abundant at many fossil localities in Florida. Analysis of specimens from 16 late Blancan localities from peninsular Florida demonstrate the presence of two species of Procyon and one species of Nasua. Procyon gipsoni sp. nov. is slightly larger than extant Procyon lotor and is distinguished by five dental characters including a lack of a crista between the para- cone and hypocone on the P4, absence of a basin at the lingual intersection of the hypocone and protocone on the P4, and a reduced metaconule on the M1. Procyon megalokolos sp. nov. is significantly larger than extant P. lotor and is characterized primarily by morphology of the postcrania, such as an expanded and posteriorly rotated humeral medial epicondyle, more prominent tibial tuberosity, and more pronounced radioulnar notch. Other than larger size, the dentition of P. megalokolos falls within the range of variation observed in extant P. lotor, suggesting that it may be an early member of the P. lotor lineage. Nasua mast- odonta sp. nov. has a unique accessory cusp on the m1 as well as multiple morphological differences in the dentition and postcrania, such as close appression of the trigonid of the m1 and a less expanded medial epicondyle of the humerus. We also synonymize Procyon rexroadensis, formerly the only known Blancan Procyon species in North America, with P. lotor due to a lack of distinct dental morphological features observed in specimens from its type locality in Kansas. -
Agent for Expelling Parasites in Humans, Animals Or Birds
(19) TZZ Z_T (11) EP 2 496 089 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A01N 65/00 (2009.01) A01N 65/10 (2009.01) 22.02.2017 Bulletin 2017/08 A61K 36/23 (2006.01) A01P 5/00 (2006.01) (21) Application number: 10803029.7 (86) International application number: PCT/BE2010/000077 (22) Date of filing: 05.11.2010 (87) International publication number: WO 2011/054066 (12.05.2011 Gazette 2011/19) (54) AGENT FOR EXPELLING PARASITES IN HUMANS, ANIMALS OR BIRDS MITTEL ZUR ABWEISUNG VON PARASITEN BEI MENSCHEN, TIEREN ODER VÖGELN AGENT POUR EXPULSER DES PARASITES CHEZ DES HUMAINS, DES ANIMAUX OU DES OISEAUX (84) Designated Contracting States: (56) References cited: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB • RAMADAN NASHWA I ET AL: "The in vitro effect GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO of assafoetida on Trichomonas vaginalis", PL PT RO RS SE SI SK SM TR JOURNAL OF THE EGYPTIAN SOCIETY OF PARASITOLOGY, EGYPTIAN SOCIETY OF (30) Priority: 06.11.2009 BE 200900689 PARAS1TOLOGY, CAIRO, EG, vol. 33, no. 2, 1 August 2003 (2003-08-01) , pages 615-630, (43) Date of publication of application: XP009136264, ISSN: 1110-0583 12.09.2012 Bulletin 2012/37 • DATABASE MEDLINE [Online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, (73) Proprietors: US; December 2004 (2004-12), RAMADAN • MEIJS, Maria Wilhelmina NASHWA I ET AL: "Effect of Ferula assafoetida 4852 Hombourg (BE) on experimental murine Schistosoma mansoni • VAESSEN, Jan Jozef infection.", XP002592455, Database accession 4852 Hombourg (BE) no. -
Fibre Couplings in the Placenta of Sperm Whales, Grows to A
news and views Most (but not all) nematodes are small Daedalus and nondescript. For example, Placento- T STUDIOS nema gigantissima, which lives as a parasite Fibre couplings in the placenta of sperm whales, grows to a CS./HOL length of 8 m, with a diameter of 2.5 cm. The The nail, says Daedalus, is a brilliant and free-living, marine Draconema has elongate versatile fastener, but with a fundamental O ASSO T adhesive organs on the head and along the contradiction. While being hammered in, HO tail, and moves like a caterpillar. But the gen- it is a strut, loaded in compression. It must BIOP eral uniformity of most nematode species be thick enough to resist buckling. Yet has hampered the establishment of a classifi- once in place it is a tie, loaded in tension, 8 cation that includes both free-living and par- and should be thin and flexible to bear its asitic species. Two classes have been recog- load efficiently. He is now resolving this nized (the Secernentea and Adenophorea), contradiction. based on the presence or absence of a caudal An ideal nail, he says, should be driven sense organ, respectively. But Blaxter et al.1 Figure 2 The bad — eelworm (root knot in by a force applied, not to its head, but to have concluded from the DNA sequences nematode), which forms characteristic nodules its point. Its shaft would then be drawn in that the Secernentea is a natural group within on the roots of sugar beet and rice. under tension; it could not buckle, and the Adenophorea. -
Subclase Secernentea
Orden Ascaridida T. 21. ASCARIDIDOS. Generalidades y Clasificación. Incluye parásitos con tres labios de gran tamaño. En los machos, cuando existen alas caudales, éstas se localizan Ascaridioideos y Anisakoideos. lateralmente. 1. GENERALIDADES Y CLASIFICACIÓN Los ascarídidos son nematodos con fasmidios (quimiorreceptores posteriores); pertenecen por tanto a la Clase Secernentea. Los machos presentan generalmente alas caudales o bolsas copuladoras. Los ascarídidos de interés veterinario se clasifican en base al siguiente esquema taxonómico: Orden Ascaridida Superfamilia Ascaridoidea Familia Ascarididae Género Ascaris Género Parascaris Género Toxocara Género Toxascaris Fig. 1. Extremo caudal del macho en Ascarididae. Superfamilia Anisakoidea Familia Anisakidae Género Anisakis Superfamilia Ascaridoidea Género Contracaecum Género Phocanema Por lo general son nematodos de gran tamaño. No Género Pseudoterranova presentan cápsula bucal y el esófago carece de bulbo posterior Superfamilia Heterakoidea pronunciado. En algunas especies el esófago está seguido de un Familia Heterakidae: G. Heterakis ventrículo posterior corto que puede derivarse en un apéndice Familia Ascaridiidae: G. Ascaridia 1 ventricular, mientras que otras presentan una prolongación del 2.1. GÉNERO ASCARIS intestino en sentido craneal que se conoce como ciego intestinal (Fig. 12, Familia Anisakidae). Existen dos espículas en los machos Ascaris suum y el ciclo de vida puede ser directo o indirecto. Es un parásito del cerdo con distribución cosmopolita y de 2. FAMILIA ASCARIDIDAE considerable importancia económica. Sin embargo, su prevalencia está disminuyendo debido a los cada vez más frecuentes sistemas Los labios, que como característica del Orden están bien de producción intensiva y a la instauración de tratamientos desarrollados, presentan una serie de papilas labiales externas e antihelmínticos periódicos. Durante años se ha considerado internas, así como un borde denticular en su cara interna.