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Monday Program MONDAY PROGRAM SUNDAY, JANUARY 27 12:00 - Registration Lobby (1F) 18:00 17:00 - Welcome Reception Lobby (1F) 19:00 MONDAY, JANUARY 28 07:00 Registration Lobby (1F) 08:00 Opening Ceremony Grand Ballroom 101~105 (1F) PLENARY PRESENTATION I Session Chair: Shoji Takeuchi, The University of Tokyo, JAPAN Grand Ballroom 101~105 (1F) 08:30 CARDIOMYOCYTES AS HIGH-POWER BUILDING BLOCKS FOR BIO- HYBRID MACHINES Kit Parker Harvard University, USA In an effort to better understand the human heart, our team initiated an effort to identify the fundamental rules of muscular pumps. We reasoned that by reverse engineering marine lifeforms, we would be better able to understand the structure- function relationships in the heart. We reverse engineered life forms such as the jellyfish and sting ray by elucidating how they are built and how they swim. These studies led us to the conclusion that we could use cardiac myocytes as a building block to replicate these marine structure-function relationships in synthetic systems. Furthermore, we decided to use robotics, specifically biohybrid robotics, as an experimental tool to study the fundamental design of muscular pumps. I will present results from these studies. Oral Session I : Micro Robots Session Chair: Franz Lärmer, Bosch, GERMANY Grand Ballroom 101~105 (1F) 09:30 AWARD NOMINEE* DESIGN OF THE FIRST SUB-MILLIGRAM FLAPPING WING AERIAL VEHICLE Palak Bhushan and Claire J. Tomlin University of California, Berkeley, USA Here we report the first sub-milligram flapping wing vehicle which is able to mimic insect wing kinematics. Wing stroke amplitude of 90º and wing pitch amplitude of 80º is demonstrated. This is also the smallest wingspan (single wing length of 3.5mm) device reported yet and is at the same mass-scale as a fruit fly. Assembly has been made simple and requires gluing together 5 components in contrast to higher part count and intensive assembly of other milligram-scale microrobots. This increases the fabrication speed and success-rate of the fully fabricated device. Low operational voltages (70mV) makes testing further easy and will enable eventual deployment of autonomous sub-milligram aerial vehicles. - 36 - MONDAY PROGRAM Oral Session I : Micro Robots(continued) Grand Ballroom 101~105 (1F) 09:45 A FAST-MOVING MICRO CRAWLING ROBOT WITH DIRECT ELECTROMAGNETIC DRIVING MECHANISM Xinyi Liu1, Zhiwei Liu1, Mingjing Qi1,3, Yangsheng Zhu1, Dawei Huang1, Xiaoyong Zhang1,3, Liwei Lin5, and Xiaojun Yan1,2,3,4 1Beihang University, CHINA, 2Collaborative Innovation Center of Advanced Aero-Engine, CHINA, 3National Key Laboratory of Science and Technology on Aero-Engine Aero- thermodynamics, CHINA, 4Beijing Key Laboratory of Aero-Engine Structure and Strength, CHINA, and 5University of California, Berkeley, USA We present a fast-moving micro crawling robot driven directly by electromagnetically induced resonance for the first time. The forelegs of the crawling robot are glued to the resonating beams and can achieve periodical raise and recover motions to realize forward movement. Under an applied AC voltage of 4 V, the crawling robot with a total mass of 137 mg can achieve a maximum crawling speed of 232 mm/s (18.9 body lengths per second). As such, this work presents a new efficient direct driving scheme for the legged micro crawling robots. 10:00 3-D MICRO SWIMMING DRONE WITH MANEUVERABILITY Fang-Wei Liu and Sung Kwon Cho University of Pittsburgh, USA Wirelessly powered and controllable microscale propulsion in 3-D space is of critical importance to micro swimming drones serving as an active and maneuverable in vivo cargo for medical uses. This aritcle describes a 3-D micro swimming drone navigating in 3-D space, propelled by unidirectional microstreaming flow from acoutsically oscillating bubbles. 3-D propulsion is enabled by multiple bubbles with different lengths embedded in different orientations inside the drone body. Each bubble generats propulsion by applying acoustic field at its resonance frequency. Therefore, 3-D propulsion in any direction is achievable by resonating bubbles individually or jointly. The drone with such a complex design was fabricated by a two- photon polymerization 3-D printer. For stable maneuverability, a non-uniform mass distribution of the drone is designed to restore the drone to the designated posture under any disturbances. The restoration mechanism is formulated by a mathematical model, predicting the restoring time and shows an excellent agreemnt with the experimental results. This 3-D micro swimning drone proves its robustness as a manueverable microrobot navigating along programmble path in a 3-D space through selective and joint actuation of microbubbles. 10:15 Break & Exhibition Inspection - 37 - MONDAY PROGRAM Oral Session II : Implantable Devices & Materials Session Chair: Karen Cheung, University of British Columbia, CANADA Mehmet Cagatay Tarhan, IEMN, FRANCE Grand Ballroom 101~105 (1F) 10:45 AWARD NOMINEE* SIDE-VIEW RAMAN MICROENDOSCOPE WITH MICRO STEPPING MOTOR AND ITS EX-VIVO TEST FOR REAL-TIME CANCER DETECTION Sayed Mohammad Hashem Jayhooni1, Michael Short2, Babak Assadsangabi1, Haishan Zeng2, and Kenichi Takahata1 1University of British Columbia, CANADA and 2BC Cancer Agency Research Centre, CANADA This paper reports a microactuator-enabled sideview Raman microendoscope device developed for realtime, angle-resolved screening of cancers growing within narrow lumens including peripheral lung bronchi. A tubular micro stepping motor, assisted with a self-sustained ferrofluid bearing, is custom developed and integrated with a Raman spectroscopic probe via biocompatible packaging for full circumferential step scan of a probing laser beam. The performance of microfabricated prototype is assessed using reference chemicals to show the targeted function for circumferentially localized Raman data collection and analysis. Ex-vivo testing was successfully conducted to demonstrate intraluminal Raman analysis in animal bronchi with >99% spectral accuracy in real time. 11:00 ULTRA-THIN PARYLENE-C DEPOSITION ON PDMS Yaoping Liu1, Xiao Dong1, Xinyue Deng1,2, Thuan Beng Saw3, Chwee Teck Lim3, Jingquan Liu4,5, and Wei Wang1,4 1Peking University, CHINA, 2Peking University Health Science Center, CHINA, 3National University of Singapore, SINGAPORE, 4National Key Laboratory of Science and Technology on Micro/Nano Fabrication, CHINA, and 5Shanghai Jiao Tong University, CHINA This study reports the ultra-thin Parylene-C deposition on PDMS substrate for a controllable and reliable process of Parylene-C caulked PDMS (pcPDMS). This work covers the depositions on PDMS substrates with different prepolymer ratios (mass of base to curing agent, @ 10:1, 30:1 and 50:1). Stiffness could be modulated in a wide range via the proposed pcPDMS process. The prepared pcPDMS would find applications in biomedical studies, such as mechanobiology. - 38 - MONDAY PROGRAM Oral Session II : Implantable Devices & Materials(continued) Grand Ballroom 101~105 (1F) 11:15 WIRELESS IMPLANTABLE INTRAOCULAR PRESSURE SENSOR WITH PARYLENE-OIL-ENCAPSULATION AND FORWARD-ANGLED RF COIL Aubrey Shapero1, Abhinav Agarwal1, Juan Carlos Martinez2, Azita Emami1, Mark S. Humayun2, and Yu-Chong Tai1 1California Institute of Technology, USA and 2University of Southern California, USA This paper presents a wireless and implantable intraocular pressure (IOP) sensor with parylene-oil-encapsulation packaging using a novel folded PCB architecture accomplishing practical RF coupling for power and data in a rabbit. The sensor is operated with an air gap of 5 mm between the primary coil and the animal, coupling to an on-chip coil at an input power of 32 dBm at 915 MHz, and can also be operated when the eyelid covers the sensor. Additionally, two novel results for parylene-on-oil deposition in general are presented. First, we show that the thickness of the porous layer of parylene-C (PA-C) and parylene-HT (PA-HT) deposited on silicone oils have a logarithmic decrease in porous layer thickness (PLT) versus silicone oil molecular weight (MW) over a range of 2-139 kDa. Second, we directly verify that parylene-oil-encapsulated pressure sensors retain sensitivity despite material buildup for the first time 11:30 SELF-POWERED IMPLANTABLE BIO-MEMS: FROM EPILEPSY DIAGNOSIS TO TREATMENT AND MONITORING Yujia Zhang1,2, Zhitao Zhou1, and Tiger H. Tao1,2 1Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, CHINA and 2University of Chinese Academy of Sciences, CHINA We report an implantable, biodegradable, and multifunctional system, self- powered with silk-based triboelectric nanogenerators (S-TENGs), for real time in vivo monitoring and therapeutic treatments of epileptic seizures. These S-TENGs are efficient energy harvesters with customizable in vivo operating life and biomechanical sensitivity via synergetic adjustments of silk molecular sizes, surface structuralization, and device configuration. A proof-of-principle S-TENG-based device is built with “smart” treatment triggered by specific epilepsy-induced symptoms and wirelessly mobile- device readout, exhibiting the practical potential of these S-TENGs as self-powered implantable bioelectronics and medical platforms. After completion of functions, S-TENGs are safely resorbed into the body within a programmable period, with post- operation sterilization simultaneously. 11:45 LOW-COST, LOW-IMPEDANCE POLYIMIDE BASED MICRO-NEEDLE ARRAY (PI-MNA): A MINIMALLY INVASIVE FLEXIBLE DRY ELECTRODE FOR SURFACE BIO-POTENTIAL MONITORING Junshi Li1, Zhengkun Shen1,
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