bioRxiv preprint doi: https://doi.org/10.1101/2020.06.28.174821; this version posted October 29, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 1 Müller Glia regenerative potential is maintained throughout life despite 2 neurodegeneration and gliosis in the ageing zebrafish retina 3 4 AUTHORS 5 Raquel R. Martins1,2, Mazen Zamzam3, Mariya Moosajee4,5,6,7, Ryan Thummel3, Catarina M. 6 Henriques1,2§, Ryan B. MaCDonald4§ 7 8 Affiliations: 9 1. Bateson Centre, University of Sheffield, Sheffield, S10 2TN, UK. 10 2. Department of OnCology and Metabolism, University of Sheffield, Sheffield, S10 2TN 11 UK. 12 3. Department of Ophthalmology, Visual and AnatomiCal SCienCes, Wayne State 13 University School of MediCine, Detroit, MI 48201, USA. 14 4. Institute of Ophthalmology, University College London, London, EC1V 9EL, UK. 15 5. Moorfields Eye Hospital NHS Foundation Trust, London, EC1V 2PD, UK 16 6. Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 17 3JH, UK 18 7. The FranCis CriCk Institute, London, NW1 1AT, London 19 20 21 22 §Co-corresponding authors:
[email protected] and
[email protected] 23 24 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.06.28.174821; this version posted October 29, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 25 ABSTRACT 26 Ageing is a signifiCant risk faCtor for degeneration of the retina.