Neural Correlates of Prospection Impairments in Schizophrenia
Psychiatry Research: Neuroimaging 293 (2019) 110987 Contents lists available at ScienceDirect Psychiatry Research: Neuroimaging journal homepage: www.elsevier.com/locate/psychresns Neural correlates of prospection impairments in schizophrenia: Evidence from voxel-based morphometry analysis T Yang Zhuo-yaa,b, Wang Shuang-kunc, Li Yinga,b,d, Wang Yia, Wang Yong-minga,b,e,f, Zhou Han-yua,b, Cai Xin-lua,b,e,f, Cheung Eric F.C.g, David H.K. Shumh,a, Dost Öngüri, ⁎ Chan Raymond C.K.a,b, a Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China b Department of Psychology, University of Chinese Academy of Sciences, Beijing, China c Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China d Haidian District Mental Health Prevent-Treatment Hospital, Beijing, China e Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100190, PR China f Sino-Danish Center for Education and Research, Beijing 100190, PR China g Castle Peak Hospital, Hong Kong Special Administration Region, China h Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong, China i McLean Hospital, Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA, United States of America ARTICLE INFO ABSTRACT Keywords: Prospection, which has a close relationship with motivation and goal-directed behavior, could be a potential Prospection target for alleviating negative symptoms. The present study aimed to examine the structural neural correlates of Working memory prospection impairments and the involvement of working memory in prospection in schizophrenia patients. Schizophrenia Thirty-seven patients with schizophrenia and 28 healthy controls were recruited and all of them completed a Voxel-based morphometry prospection task.
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