INVITATION ORGANIZERS

The German-Israeli Cooperation in Cancer Research was Scientific Program Committee founded in 1976 and is the longest lasting scientific coop- Ministry of Science, DKFZ: Prof. Dr. Hellmut Augustin Technology and Space eration between Germany and Israel. To date 159 projects Israel: Prof. Dr. Eli Pikarsky, Prof. Dr. Varda Rotter have been funded. Beyond this, the cooperation has led to friendships between scientists of both countries and other partners (www.dkfz.de/israel). German-Israeli Cooperation in Cancer Research In 2013, the 6th German-Israeli Cancer Research School will DKFZ: Prof. Dr. Peter Angel take place in the Negev Desert in Israel. The focus will be on Israel: Dr. Ahmi Ben-Yehudah, Nurit Topaz mouse models of human cancer. Prominent Israeli and Ger- man scientists will present their latest advances in cancer Administrative Coordinator research. Dr. Barbara Böck Advanced preclinical tumor models have emerged as a criti- Scientific Coordinator of the Helmholtz Alliance cal bottleneck for both, the advancement of basic tumor Preclinical Comprehensive Cancer Center (PCCC) biology and for translational research. Aimed at overcom- ing this bottleneck, the speakers will highlight recent de- velopments in the field of mouse cancer models that better Contact Address MOST mimic the pathogenesis, the course and the response to Nurit Topaz therapy of human tumors. Ministry of Science, Technology and Space The format of the school will include lectures in the morn- P.O.Box 49100 ing and the late afternoon, framed by social activities. Dur- Jerusalem 91490, Israel ing the poster sessions, the participants are expected to phone: +972 2 5411157, fax: +972 2 5825725 give short presentations, highlighting their research proj- e-mail: [email protected] ects. The best three posters will be awarded. The 6th German-Israeli Cancer Research School is supported Contact Address DKFZ by the Joint Scientific Program Committee of the Coopera- Elfriede Mang tion and is jointly organized by Prof. Hellmut Augustin and German Cancer Research Center Prof. Eli Pikarsky. The aim of this school is to offer a plat- Im Neuenheimer Feld 280 form for intense interactions between PhD students, young 69120 Heidelberg, Germany postdocs and principal investigators of the program from phone: +49 6221 42 4499, fax :+49 6221 42 4498 both, Israel and Germany. e-mail: [email protected] In 2008, the first school was held in Pichl (Austria) and was such a great success that immediately afterwards the PhD In cooperation with students requested the school to be held every year, alter- nating between Pichl and Israel. This year, we come up with an ambitious program which will hopefully enhance 6th German-Israeli Cancer Research School the exchange between young investigators and senior scientists from both countries. We look forward to your Helmholtz Alliance application! Preclinical Comprehensive Cancer Center Mouse Models of Human Cancer

th th Peter Angel Ahmi Ben-Yehudah November 9 – 13 , 2013, Negev Desert/Israel Club Ramon Hotel, Mitzpe Ramon NOVEL TECHNOLOGIES TUMOR MICROENVIRONMENT AND Saturday, November 9th, 2013 17:45 Shalev Itzkovitz, Weizmann Inst. of Science, Rehovot INFLAMMATION Arrival in the afternoon Single molecule approaches for studying gene 10:15 Neta Erez, Tel Aviv University, Tel Aviv expression in intact mammalian tissues 19:00 Dinner Co-evolution of the tumor microenvironment 18:20 Amit Benbenishty, Tel Aviv University during cancer progression and metastases Introducing a novel intra-carotid artery inoculation 11:00 Hellmut Augustin, DKFZ, Heidelberg th Sunday, November 10 , 2013 method: advantages for studying brain metastasis Animal models of tumor angiogenesis: 19:00 Safari ride to Bedouin camp, BBQ dinner Challenges and bottlenecks 08:00 Breakfast 11:45 Alexander Bott, DKFZ, Heidelberg 10:00 Welcome addresses Monday, November 11th, 2013 MicroRNAs control the pro-angiogenic switch in MSC Ilana Lowi, MOST, Jerusalem by regulating TGFβ and TNFα signaling pathways Otmar D. Wiestler, DKFZ, Heidelberg 06:00 Early morning tour along the statue promenade, with 12:05 Karina Yaniv, Weizmann Inst. of Science, Rehovot Ahmi Ben-Yehudah, MOST, Jerusalem sunrise view Elucidating the role of ApoB-containing lipoproteins Peter Angel, DKFZ, Heidelberg 07:45 Breakfast in tumor related angiogenesis and metastasis MODELS OF HUMAN CANCER 08:30 Small group work II 12:50 Lunch 14:00 Mathias Heikenwälder, Inst. of Virology, TU Munich 11:00 Hai-Kun Liu, DKFZ, Heidelberg AGEING, STEM CELLS AND CANCER Mouse models of high-grade brain tumors and their Mouse models for liver cancer – only models or more? 11:00 Haim Cohen, Bar Ilan-University, Ramat Gan preclinical applications The tumorigenesis aspect of mouse models of longevity 14:45 Polina Weitzenfeld, Tel Aviv University

11:45 Dieter Saur, Technical University, Munich Ménage-a-trois between the inflammatory, hormonal 11:45 Chul Min Yang, Georg-Speyer-Haus, Frankfurt Dual recombination systems for time and host and growth-supporting arms of the tumor micro- Reprogramming of tumor cells: Signaling events and specific genetic manipulation of gastrointestinal environment potentiates metastasis formation in phenotypes cancer breast cancer 12:05 Varda Rotter, Weizmann Institute of Science, Rehovot 15:05 Eli Pikarsky, Hebrew University, Jerusalem 12:30 Sami Stalin, Ben-Gurion University of the Negev, The role of p53 in the stem cell cancer stem cell loop Beer-Sheva Hepatocellular carcinoma: Linking inflammation The detrimental effects of microenvironment- 12:50 Lunch and cancer derived IL-1 for the development of gastrointestinal 14:00 Poster session and discussion 15:50 Dharanija Madhavan, DKFZ, Heidelberg tract tumors 16:00 Presentation of small group work Circulating microRNAs as surrogate marker for circulating tumor cells and prognostic markers in 12:50 Hanna Bergmann, Technical University Munich 17:00 Sunset tour by foot along the cliff of the crater metastatic breast cancer Card9 signaling in the innate immune system drives 18:30 Dinner carcinogenesis in the colon under inflammatory 20:00 Uri Alon, Weizmann Institute of Science, Rehovot 16:10 Yinon Ben-Neriah, Hebrew University, Jerusalem conditions Love and fear in the lab: a guitar talk on the emotional At the crossroad of senescence, inflammation and cancer 13:10 Lunch and subjective aspects of doing science 16:55 Manuel Röhrich, DKFZ, Heidelberg 14:00 Small group work I Tuesday, November 12th, 2013 Triple therapy of radiation and combined integrin and HEMATOLOGICAL MALIGNANCIES EGFR blockade in an orthotopic glioblastoma model 08:00 Breakfast 16:30 Hans-Reimer Rodewald, DKFZ, Heidelberg 17:15 Yuval Shaked, Technion, Haifa Progenitor-deprivation driven T cell leukemia in mice HEMATOLOGICAL MALIGNANCIES Studying host response to anti-cancer therapy in different animal models of cancer 17:15 Ayelet Jerafi Vider, Weizmann Inst. of Science, Rehovot 09:30 Klaus Rajewsky, MDC Berlin 18:00 Plenary discussion A new role for p53 and the Δ113p53 isoform in Autonomy and context dependence of B cell lymphatic formation lymphomagenesis 19:00 Dinner