Century Association Nobelists
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Curriculum Vitae Prof. Dr. John Howard Northrop
Curriculum Vitae Prof. Dr. John Howard Northrop Name: John Howard Northrop Lebensdaten: 5. Juli 1891 ‐ 27. Mai 1987 John Howard Northrop war ein US‐amerikanischer Biochemiker, Biophysiker und Bakteriologe. Er lieferte Arbeiten zur Charakterisierung von Proteinen. Darüber hinaus listete er Grundsätze auf, die bei der Isolierung und Reindarstellung von Enzymen generell beobachtet werden können. Außerdem entwickelte er experimentelle Methoden, mit denen nachgewiesen werden konnte, dass kristallisierte Proteine reine Verbindungen sind, die volle Enzymaktivität besitzen. Für die Darstellung von Enzymen und Virusproteinen in reiner Form wurde er 1946 gemeinsam mit seinem Landsmann, dem Biochemiker Wendell Meredith Stanley, mit dem Nobelpreis für Chemie ausgezeichnet. Akademischer und beruflicher Werdegang John Howard Northrop studierte ab 1908 Chemie und Zoologie an der Columbia University in New York. Die Ausbildung schloss er 1912 mit einem Bachelor of Science ab. Ein Jahr später erhielt er den Master of Arts. 1915 wurde er im Fach Chemie promoviert. Im Anschluss war er mit einem Stipendium am Jacques Loeb Laboratory tätig, das zum Rockefeller Institute gehört. 1916 nahm man ihn in den Mitarbeiterstab des Rockefeller Institute for Medical Research auf, 1924 wurde er Vollmitglied. Northrop blieb dort bis zu seiner Emeritierung im Jahr 1961. Während des Ersten Weltkriegs verpflichtete sich Northrop für den Kriegsdienst. Er war im Rang eines Hauptmanns tätig. Nach Kriegsende wandte er sich wieder seiner Forschungsarbeit am Rockefeller Institute in New York zu. 1939 war Northrop Gastprofessor an der University of California; ein Jahr später Lektor an der John Hopkins University. 1942 wurde er in die National Defense Research Commission berufen, ein Gremium, über das die amerikanische Forschung während des Zweiten Weltkriegs koordiniert Nationale Akademie der Wissenschaften Leopoldina www.leopoldina.org 1 wurde. -
Insight from the Sociology of Science
CHAPTER 7 INSIGHT FROM THE SOCIOLOGY OF SCIENCE Science is What Scientists Do It has been argued a number of times in previous chapters that empirical adequacy is insufficient, in itself, to establish the validity of a theory: consistency with the observable ‘facts’ does not mean that a theory is true,1 only that it might be true, along with other theories that may also correspond with the observational data. Moreover, empirical inadequacy (theories unable to account for all the ‘facts’ in their domain) is frequently ignored by individual scientists in their fight to establish a new theory or retain an existing one. It has also been argued that because experi- ments are conceived and conducted within a particular theoretical, procedural and instrumental framework, they cannot furnish the theory-free data needed to make empirically-based judgements about the superiority of one theory over another. What counts as relevant evidence is, in part, determined by the theoretical framework the evidence is intended to test. It follows that the rationality of science is rather different from the account we usually provide for students in school. Experiment and observation are not as decisive as we claim. Additional factors that may play a part in theory acceptance include the following: intuition, aesthetic considerations, similarity and consistency among theories, intellectual fashion, social and economic influences, status of the proposer(s), personal motives and opportunism. Although the evidence may be inconclusive, scientists’ intuitive feelings about the plausibility or aptness of particular ideas will make it appear convincing. The history of science includes many accounts of scientists ‘sticking to their guns’ concerning a well-loved theory in the teeth of evidence to the contrary, and some- times in the absence of any evidence at all. -
Why Joseph Erlanger Rejected the Local Circuit Theory of Nerve Impulse Propagation
Why Joseph Erlanger Rejected the Local Circuit Theory of Nerve Impulse Propagation Greg Gandenberger University of Pittsburgh, Department of History and Philosophy of Science 1017 Cathedral of Learning, Pittsburgh, PA 15260. [email protected] Abstract In the 1920s and 1930s, Joseph Erlanger and his colleagues expressed doubts about the local circuit theory of nerve impulse propagation in some of their publications. In 1934, their scepticism inspired Alan Hodgkin to begin a series of experiments that are generally regarded as providing strong support for the local circuit theory. Hodgkin’s experiments are well known, but the nature and sources of Erlanger’s scepticism are not. In the mid-1920s, Erlanger believed that oscillograph recordings indicated that the eddy currents generated by action currents are too small to propagate the nerve impulse as the local circuit theory proposes. In the 1930s, his fundamental objection to the local circuit theory was his belief that eddy currents large enough to propagate nerve impulses would dissipate a large amount of energy and produce uncontrolled stray effects. However, a 1936 discovery led him to admit that eddy currents do at least increase the excitability of an active fiber ahead of the action current wave. His opposition to the local circuit theory diminished further as a result of several developments between late 1938 and early 1939, including most notably Hodgkin demonstration that the resistance of the medium outside the active nerve affects propagation velocity. Word Count: 7467 Keywords Joseph Erlanger; Alan Hodgkin; local circuit theory; membrane theory; St. Louis School; electrophysiology 1. Introduction Early in his 1934-1935 year as a Cambridge undergraduate, Alan Hodgkin discovered that a blocked nerve impulse increases the excitability of the nerve beyond the block. -
The Joys and Burdens of Our Heroes 12/05/2021
More Fun Than Fun: The Joys and Burdens of Our Heroes 12/05/2021 An iconic photo of Konrad Lorenz with his favourite geese. Photo: Willamette Biology, CC BY-SA 2.0 This article is part of the ‘More Fun Than Fun‘ column by Prof Raghavendra Gadagkar. He will explore interesting research papers or books and, while placing them in context, make them accessible to a wide readership. RAGHAVENDRA GADAGKAR Among the books I read as a teenager, two completely changed my life. One was The Double Helix by Nobel laureate James D. Watson. This book was inspiring at many levels and instantly got me addicted to molecular biology. The other was King Solomon’s Ring by Konrad Lorenz, soon to be a Nobel laureate. The study of animal behaviour so charmingly and unforgettably described by Lorenz kindled in me an eternal love for the subject. The circumstances in which I read these two books are etched in my mind and may have partly contributed to my enthusiasm for them and their subjects. The Double Helix was first published in London in 1968 when I was a pre-university student (equivalent to 11th grade) at St Joseph’s college in Bangalore and was planning to apply for the prestigious National Science Talent Search Scholarship. By then, I had heard of the discovery of the double-helical structure of DNA and its profound implications. I was also tickled that this momentous discovery was made in 1953, the year of my birth. I saw the announcement of Watson’s book on the notice board in the British Council Library, one of my frequent haunts. -
書 名 等 発行年 出版社 受賞年 備考 N1 Ueber Das Zustandekommen Der
書 名 等 発行年 出版社 受賞年 備考 Ueber das Zustandekommen der Diphtherie-immunitat und der Tetanus-Immunitat bei thieren / Emil Adolf N1 1890 Georg thieme 1901 von Behring N2 Diphtherie und tetanus immunitaet / Emil Adolf von Behring und Kitasato 19-- [Akitomo Matsuki] 1901 Malarial fever its cause, prevention and treatment containing full details for the use of travellers, University press of N3 1902 1902 sportsmen, soldiers, and residents in malarious places / by Ronald Ross liverpool Ueber die Anwendung von concentrirten chemischen Lichtstrahlen in der Medicin / von Prof. Dr. Niels N4 1899 F.C.W.Vogel 1903 Ryberg Finsen Mit 4 Abbildungen und 2 Tafeln Twenty-five years of objective study of the higher nervous activity (behaviour) of animals / Ivan N5 Petrovitch Pavlov ; translated and edited by W. Horsley Gantt ; with the collaboration of G. Volborth ; and c1928 International Publishing 1904 an introduction by Walter B. Cannon Conditioned reflexes : an investigation of the physiological activity of the cerebral cortex / by Ivan Oxford University N6 1927 1904 Petrovitch Pavlov ; translated and edited by G.V. Anrep Press N7 Die Ätiologie und die Bekämpfung der Tuberkulose / Robert Koch ; eingeleitet von M. Kirchner 1912 J.A.Barth 1905 N8 Neue Darstellung vom histologischen Bau des Centralnervensystems / von Santiago Ramón y Cajal 1893 Veit 1906 Traité des fiévres palustres : avec la description des microbes du paludisme / par Charles Louis Alphonse N9 1884 Octave Doin 1907 Laveran N10 Embryologie des Scorpions / von Ilya Ilyich Mechnikov 1870 Wilhelm Engelmann 1908 Immunität bei Infektionskrankheiten / Ilya Ilyich Mechnikov ; einzig autorisierte übersetzung von Julius N11 1902 Gustav Fischer 1908 Meyer Die experimentelle Chemotherapie der Spirillosen : Syphilis, Rückfallfieber, Hühnerspirillose, Frambösie / N12 1910 J.Springer 1908 von Paul Ehrlich und S. -
Plant Viruses
Western Plant Diagnostic Network1 First Detector News A Quarterly Pest Update for WPDN First Detectors Spring 2015 edition, volume 8, number 2 In this Issue Page 1: Editor’s Note Dear First Detectors, Pages 2 – 3: Intro to Plant Plant viruses cause many important plant diseases and are Viruses responsible for huge losses in crop production and quality in Page 4: Virus nomenclature all parts of the world. Plant viruses can spread very quickly because many are vectored by insects such as aphids and Page 5 – Most Serious World Plant Viruses & Symptoms whitefly. They are a major pest of crop production as well as major pests of home gardens. By mid-summer many fields, Pages 6 – 7: Plant Virus vineyards, orchards, and gardens will see the effects of plant Vectors viruses. The focus of this edition is the origin, discovery, taxonomy, vectors, and the effects of virus infection in Pages 7 - 10: Grapevine plants. There is also a feature article on grapevine viruses. Viruses And, as usual, there are some pest updates from the West. Page 10: Pest Alerts On June 16 – 18, the WPDN is sponsoring the second Invasive Snail and Slug workshop at UC Davis. The workshop Contact us at the WPDN Regional will be recorded and will be posted on the WPDN and NPDN Center at UC Davis: home pages. Have a great summer and here’s hoping for Phone: 530 754 2255 rain! Email: [email protected] Web: https://wpdn.org Please find the NPDN family of newsletters at: Editor: Richard W. Hoenisch @Copyright Regents of the Newsletters University of California All Rights Reserved Western Plant Diagnostic Network News Plant Viruses 2 Ag, Manitoba Photo courtesy Photo Food, and Rural Initiatives and Food, of APS Photo by Giovanni Martelli, U of byBari Giovanni Photo Grapevine Fanleaf Virus Peanut leaf with Squash Mosaic Virus tomato spotted wilt virus Viruses are infectious pathogens that are too small to be seen with a light microscope, but despite their small size they can cause chaos. -
Discovery of DNA Structure and Function: Watson and Crick By: Leslie A
01/08/2018 Discovery of DNA Double Helix: Watson and Crick | Learn Science at Scitable NUCLEIC ACID STRUCTURE AND FUNCTION | Lead Editor: Bob Moss Discovery of DNA Structure and Function: Watson and Crick By: Leslie A. Pray, Ph.D. © 2008 Nature Education Citation: Pray, L. (2008) Discovery of DNA structure and function: Watson and Crick. Nature Education 1(1):100 The landmark ideas of Watson and Crick relied heavily on the work of other scientists. What did the duo actually discover? Aa Aa Aa Many people believe that American biologist James Watson and English physicist Francis Crick discovered DNA in the 1950s. In reality, this is not the case. Rather, DNA was first identified in the late 1860s by Swiss chemist Friedrich Miescher. Then, in the decades following Miescher's discovery, other scientists--notably, Phoebus Levene and Erwin Chargaff--carried out a series of research efforts that revealed additional details about the DNA molecule, including its primary chemical components and the ways in which they joined with one another. Without the scientific foundation provided by these pioneers, Watson and Crick may never have reached their groundbreaking conclusion of 1953: that the DNA molecule exists in the form of a three-dimensional double helix. The First Piece of the Puzzle: Miescher Discovers DNA Although few people realize it, 1869 was a landmark year in genetic research, because it was the year in which Swiss physiological chemist Friedrich Miescher first identified what he called "nuclein" inside the nuclei of human white blood cells. (The term "nuclein" was later changed to "nucleic acid" and eventually to "deoxyribonucleic acid," or "DNA.") Miescher's plan was to isolate and characterize not the nuclein (which nobody at that time realized existed) but instead the protein components of leukocytes (white blood cells). -
Mobile DNA Elements in Shigella Flexneri and Emergence of An- Tibiotic Resistance Crisis
International Journal of Genomics and Data Mining Palchauduri S, et al. Int J Genom Data Min 01: 111. Research Article DOI: 10.29011/2577-0616.000111 Mobile DNA Elements in Shigella flexneri and Emergence of An- tibiotic Resistance Crisis Sunil Palchaudhuri1*, Anubha Palchaudhuri2, Archita Biswas2 1Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, USA 2Atlanta Health Centre, Kolkata, India *Corresponding author: Sunil Palchaudhuri,Department of Immunology and Microbiology, Wayne State University School of Medicine, 540 E Canfield St, Detroit, MI 48201, USA. Tel: +13135771335; Email: [email protected] Citation:Palchaudhuri S, Palchaudhuri A, Biswas A (2017)Mobile DNA Elements in Shigella flexneri and Emergence of Antibiotic Resistance Crisis. Int J Genom Data Min 01: 111. DOI: 10.29011/2577-0616.000111 Received Date: 18October, 2017; Accepted Date: 23 October, 2017; Published Date: 30 October, 2017 Introduction F Plasmid-Lederberg’s Fertility factor F of E. coli K-12. Prokaryotic mobile DNA elements were initially observed by • 100 Kb. Nobel Prize Winner Professor Barbara McClintock in 1983. Both • ori F-origin of F plasmid replication. (With the sequence for IS and Tn elements are defined as mobile DNA elements capable dna A gene to function) of inserting into many different sites of a single chromosome or different chromosomes as discrete, non-permuted DNA segments • rep-replication functions. [1,2]. In 1952 Dr Joshua Lederberg (a noble prize winner of 1958) • IS-insertion sequence (IS2, IS3 and IS1copies present in the has shown the presence of such elements IS1, IS2, IS3 and Tn host E. coli K-12. -
Cambridge's 92 Nobel Prize Winners Part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin
Cambridge's 92 Nobel Prize winners part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin By Cambridge News | Posted: January 18, 2016 By Adam Care The News has been rounding up all of Cambridge's 92 Nobel Laureates, celebrating over 100 years of scientific and social innovation. ADVERTISING In this installment we move from 1951 to 1974, a period which saw a host of dramatic breakthroughs, in biology, atomic science, the discovery of pulsars and theories of global trade. It's also a period which saw The Eagle pub come to national prominence and the appearance of the first female name in Cambridge University's long Nobel history. The Gender Pay Gap Sale! Shop Online to get 13.9% off From 8 - 11 March, get 13.9% off 1,000s of items, it highlights the pay gap between men & women in the UK. Shop the Gender Pay Gap Sale – now. Promoted by Oxfam 1. 1951 Ernest Walton, Trinity College: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei 2. 1951 John Cockcroft, St John's / Churchill Colleges: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei Walton and Cockcroft shared the 1951 physics prize after they famously 'split the atom' in Cambridge 1932, ushering in the nuclear age with their particle accelerator, the Cockcroft-Walton generator. In later years Walton returned to his native Ireland, as a fellow of Trinity College Dublin, while in 1951 Cockcroft became the first master of Churchill College, where he died 16 years later. 3. 1952 Archer Martin, Peterhouse: Nobel Prize in Chemistry, for developing partition chromatography 4. -
Landmarks Preservation Commission November 22, 2016, Designation List 490 LP-2579
Landmarks Preservation Commission November 22, 2016, Designation List 490 LP-2579 YALE CLUB OF NEW YORK CITY 50 Vanderbilt Avenue (aka 49-55 East 44th Street), Manhattan Built 1913-15; architect, James Gamble Rogers Landmark site: Borough of Manhattan Tax Map Block 1279, Lot 28 On September 13, 2016, the Landmarks Preservation Commission held a public hearing on the proposed designation of the Yale Club of New York City and the proposed designation of the related Landmark Site. The hearing had been duly advertised in accordance with provisions of law. Six people spoke in support of designation, including representatives of the Yale Club of New York City, Manhattan Borough President Gale A. Brewer, Historic Districts Council, New York Landmarks Conservancy, and the Municipal Art Society of New York. The Real Estate Board of New York submitted written testimony in opposition to designation. State Senator Brad Hoylman submitted written testimony in support of designation. Summary The Yale Club of New York City is a Renaissance Revival-style skyscraper at the northwest corner of Vanderbilt Avenue and East 44th Street. For more than a century it has played an important role in East Midtown, serving the Yale community and providing a handsome and complementary backdrop to Grand Central Terminal. Constructed on property that was once owned by the New York Central Railroad, it stands directly above two levels of train tracks and platforms. This was the ideal location to build the Yale Club, opposite the new terminal, which serves New Haven, where Yale University is located, and at the east end of “clubhouse row.” The architect was James Gamble Rogers, who graduated from Yale College in 1889 and attended the Ecole des Beaux Arts in Paris during the 1890s. -
The Use of Non-Human Primates in Research in Primates Non-Human of Use The
The use of non-human primates in research The use of non-human primates in research A working group report chaired by Sir David Weatherall FRS FMedSci Report sponsored by: Academy of Medical Sciences Medical Research Council The Royal Society Wellcome Trust 10 Carlton House Terrace 20 Park Crescent 6-9 Carlton House Terrace 215 Euston Road London, SW1Y 5AH London, W1B 1AL London, SW1Y 5AG London, NW1 2BE December 2006 December Tel: +44(0)20 7969 5288 Tel: +44(0)20 7636 5422 Tel: +44(0)20 7451 2590 Tel: +44(0)20 7611 8888 Fax: +44(0)20 7969 5298 Fax: +44(0)20 7436 6179 Fax: +44(0)20 7451 2692 Fax: +44(0)20 7611 8545 Email: E-mail: E-mail: E-mail: [email protected] [email protected] [email protected] [email protected] Web: www.acmedsci.ac.uk Web: www.mrc.ac.uk Web: www.royalsoc.ac.uk Web: www.wellcome.ac.uk December 2006 The use of non-human primates in research A working group report chaired by Sir David Weatheall FRS FMedSci December 2006 Sponsors’ statement The use of non-human primates continues to be one the most contentious areas of biological and medical research. The publication of this independent report into the scientific basis for the past, current and future role of non-human primates in research is both a necessary and timely contribution to the debate. We emphasise that members of the working group have worked independently of the four sponsoring organisations. Our organisations did not provide input into the report’s content, conclusions or recommendations. -
Eighty Years of Fighting Against Cancer in Serbia Ovarian Cancer Vaccine
News Eighty years of fighting against cancer Recent study by Kunle Odunsi et al., Roswell Park Cancer Institute, Buffalo, in Serbia New York, USA, showed an effects of vaccine based on NY-ESO-1, a „cancer This year on December 10th, Serbian society for the fight against cancer has testis“ antigen in preventing the recurrence of ovarian cancer. NY-ESO-1 is a ovarian celebrated the great jubilee - 80 years of its foundation. The celebration took „cancer-testis“ antigen expressed in epithelial cancer (EOC) and is place in Crystal Room of Belgrade’s Hyatt hotel, gathering many distinguished among the most immunogenic tumor antigens defined to date. presence + guests from the country and abroad. This remarkable event has been held Author’s previous study point to the role of of intraepithelial CD8 - under the auspices of the President of Republic of Serbia, Mr. Boris Tadić. infiltrating T lymphocytes in tumors that was associated with improved survival of The whole ceremony was presided by Prof. Dr. Slobodan Čikarić, actual presi- patients with the disease. The NY-ESO-1 peptide epitope, ESO157–170, is recog- + + dent of Society, who greeted guests and wished them a warm welcome. Than nized by HLA-DP4-restricted CD4 T cells and HLA-A2- and A24-restricted CD8 + followed the speech of Serbian health minister, Prof. Dr. Tomica Milosavljević T cells. To test whether providing cognate helper CD4 T cells would enhance who pointed out the importance of preventive measures and public education the antitumor immune response, Odunsi et al., conducted a phase I clinical trial along with timely diagnosis and multidisciplinary treatment in global fight of immunization with ESO157–170 mixed with incomplete Freund's adjuvant + against cancer in Serbia.