FILE COPY ecor U . S. DEPARTMENT OF November 9, 1971 HEAL.TH , EDUCATION , AND WELFARE Vol. XXIII, No. 23 NATIONAL. INSTITUTES OF HEAL.TH Dr. Herman N. Eisen Is Cancer Incidence Report HEW Sickle Cell Committee Recommends Guest Speaker at Annual Notes Some Significant Rate Changes in U.S. Allocation of Funds to Expand Program Freund Seminar Nov. 18 A preliminary report on cancer A program for expanding Federal activities diTected against sickle cell incidence in 1969 covering eight disease, in which both community-service aspects and research will re. major metropolitan areas and one ceive emphasis, has been recommended by the HEW Sickle Cell Disease entire state indicates some signif­ Advisory Committee in their icant changes of rates in the second report to Secretary Elliot United States since the last study L. Richardson. Dr. Mc(rumb Appointed was conducted in 1947. Sickle cell disease, a painful and In the report issued by the Na­ life-shortening inherited disease Fl( Special Assistant tional Cancer Institute's Biometry found almost exclusively among Branch, statisticians caution that black people, is a major health Dr. Fred R. McCrumb, Jr., the population and geographic problem here and abroad. was 1·ecently appointed special areas included in the two studies The committee, named _by Mr. assistant to the Director of the are somewhat different. Richardson to advise on Program Fogarty International Center, Dr. However, c e r ta in important objectives and priorities which will Milo D. Leavitt. trends are evident: involve NIH, HSMHA, and other Dr. McCrumb's primary as­ • The overall incidence of can­ Federal agencies, met here for the signment will be to develop a pro­ cer in men is increasing, a trend second time Oct. 7-8. gram of workshops and confer­ particularly marked among blacks, ences concerned with the preven­ while in women it is decreasing. Mrs. Aikens ls Chairman tive aspects of major human Dr. Eisen, a specialist in immunology, • The incidence of lung cancer 'l'he recommendations of the health problems. was chairman of the NIH Study Sec• has doubled in both men and wom­ committee, which is chaired by Dr. McCrumb has specialized tion on Allergy and Immunology. en of both races. Ruth L. Aikens, associate direc­ in infectious diseases and tropical • The incidence of cancer in tor for Health, National Urban medicine. The Eleventh Annual Jules blacks is substantially higher than League, N.Y.C., are concerned Conducted Plague Studies Freund Memorial Seminar will ( ee CANCER REPORT, Page 6) with goals and functional compo­ feature Dr. Herman N. Eisen nents of the program and alloca­ During service with the armed next Thursday, Nov. 18, at 1 Dr. David K. Johnson Heads tion of the additional $5 million re­ forces overseas, he carried out p.m., in the CC Jack Masur cently targeted by President field research on plague at the Auditorium. DRS Experimental Surgery Nixon for sickle cell disease. Institut Pasteur de Tananarive, nr. Eisen will discuss "Mye­ Section in Lab Aids Branch The committee recommended: Madagascar. loma PrO'teins as Antibodies and • That $2.5 million be allocat­ Also, as Commanding Officer Tumor-Specific Antigens." Dr. David K. Johnson has been ed for the establishment of up to of the U.S. Army Medical Re­ He heads the Department of named chief of the Experimental search Unit, Institute for Medi­ Surgery and Clinical Medicine Sec­ five comprehensive research and Microbiology at the Washington community service centers. cal Research, Kuala Lumpur, University School of Medicine, St. tion, Laboratory Aids Branch, Di­ Federation of Malaya, he con­ vision of Research Services. Each center would be organized Louis. around ongoing programs in sickle ducted studies on diseases of mili­ A specialist in immunology­ This section pro­ tary importance in Southeast Asia. vides experimental cell disease; and would bridge the especially antibody function, struc­ gap between fundamental re­ Between 1962 and 1967, nr. ture, and formation-Dr. Eisen surgery facilities McCrumb was professor of Inter­ and staff assist­ search, clinical application, and has been a member of the Com­ community service. (See DR. McORVMB, Page 6) mission on Immunization of the ance, special oper _ at iv e procedures, • That $1 million be allocated Armed Forces Epidemiological for the establishment of from 10 Board. a n d radiographic facilities for NIH to 20 model Screening and Edu­ Experience Noted investigators. cation Clinics in various regions He came to Washington Univer­ Dog, cat, and of the country. sity in 195'5 as professor of Med­ primate long-term These clinics would be for the icine (Dermatx>logy), and assumed holding facilities Dr. Johnson purposes of 1) screening, 2) de­ his present post in 1961. are available, along with physio­ finitive diagnosis of SCD, 3) edu­ Prior to coming to St. Louis, logical sampling and collection of cation of the population at risk he taught Industrial Medicine at specimens. The section is also re­ and of health personnel, 4) re­ New York University and was a sponsible for primate breeding ac­ ferral of patients with SCD to research assodate in immuno­ tivities. (See SICKLE OELL, Page 7) chemistry at the Sloan-Kettering Prior to his appointment as a Institute for Cancer Research. PHS Commissioned Officer, Dr. and officer in charge of the Spe­ He has been on the edi-torial Johnson held the rank of cap­ cialized Animal Colony. boards of Biochemistry, Journal tain in the iU.S. Air Force. Dr. Johnson received ·his of Immunology, Physiological R e­ He was assigned to the School D.V.M. degree from Michigan views, and the Proceedings of the of Aerospace Medicine, Brooks State in 1963, and his M.S. in Society for Experimental Biology Air Force Base, Tex., as chief Laboratory Animal Medicine from Dr. McCrumb raises horses in liberty­ ( See DR. EISEN, Page 7) of the Clinical Laboratory Branch Texas A&M in 1968. town, Md. where he makes his home. Page 2 November 9, 1971 THE NIH RECORD ecord Published biweekly at Bethesda, Md., by the Publications and Reports Branch, Office of Information, for the information of employees of the National Institutes of Health, Department of Health, Education, and Welfare, and circulated by request to interested writers and to investi­ gators in the field of biomedical and related research. The content is reprintable without permission. Pictures are available on request. The NIH Record reserves the right to make corrections, changes or dele­ tions in submitted copy in conformity with the policies of the paper and the Department of Health, Education, and Welfare. NIH Record Office ...... Bldg. 31, Rm. 2B,O3. Phone 49-62125 Dr. Robert Q. Marston, NIH Director, spoke at the first convocation of Federal Editor ...... Frances W. Davis City Colleg·e and the NIH Upward Mobility College, recently, held in the CC Jack Assistant Editor ...... Fay leviero Masur Auditorium. Dr. Andress Taylor, associate dean, Office of Experimental Staff Writer ...... Ed Driscoll Programs at Federal City Colleg·e, welcomed the audience. James Robinson, mem• ber of the Upward Mobility Steering Committee at HEW, described the start of Staff Correspondents the Upward Mobility College program. Others active in the convocation and the campus college program are (I to r): Daniel Sorenson, chairman, Upward Mobility ADA, Nelson Sparks; BHME/ OD, Florence Foelak; CC, Ann Bain­ Steering Committee at HEW; Mr, Robinson; Eugene Kinlow, director, Office of bridge; DAHM, Laura Mae Kress; DBS, Faye Peterson; DCRT, Joan Upward Mobility, HEW; Robert P. Philleo, assistant director, Training and Em• Chase; DDH, Carolyn Niblett; DMI, Beverly Warran; DN, Evelyn Laz­ ployee Development, ODA; Norma Greene, director, Upward Mobility Colleg,? at zari; DPHPE, Eleanor Wesolowski; DRG, Sue Meadows; DRR, Jerry NIH; Dr, Taylor; Richard Striker, assistant deputy director of Training and Gordon; DRS, Robert Knickerbocker; FIC, Lois P. Meng; NCI, Eliza­ Employee Development, ODA, and Stephen B-ell, employee development specialist. beth Shollenberger; NEI, Julian Morris; NHLI, Bill Sanders; NIAID, Krin Larson; NIAMD, Katie Broberg; NICHD, Lloyd Blevins; NIDR, Sue Hannon; NIEHS, Elizabeth Y. James; NIGMS, Wanda Warddell; Open Season for Fed'/ Employees Health NIMH, Daniel Rice; NINDS, Anne Tisiker; NLM, Roger Gilkeson. Benefits Program to Start November 15 An "Open Season" for the Federal Employees Health Benefits Pro­ gram will start next Monday, Nov. 15, and teTminate on Dec. 31, instead NIH Television, Radio of the previously announced dosing date of Nov. 30. Program Schedule During this period, eligible em------­ ployees may enroll, and employees under preparation at the Civil R adio already enrolled may change their Service Commission, will be de­ DISCUSSION: NIH plan, option, type of enrollment, or layed until later this month. A WGMS, AM-570~FM Stereo any combination of these. desk to desk distribution will be 103.5-Friday, about 9 :15 p.m. Three general plans are avail- made as soon as the pamphlet be­ November 12 able: Government-wide Service comes available. Judith M. S. Prewitt, DCRT Benefit Plan (Blue Cross~Blue Registration procedures will Subject: Picture Interpretation Shield), Government-wide Indem- also be announced, and assistants by Computer nity Benefit Plan (Aetna Life will answer questions and help Insurance Company), and Group employees complete forms. Per­ November 19 Dr. George Blue Spruce, Jr., Health Association Plan of Wash- sonnel offices will carry addition- ington, D.C. al forms and brochures. BHME Subject: Indian Recruitment in Other Plans Available The "Open Season" also applies Call the CC Blood Bank-Ext. 64509-to Heal-th Professions to annuitants enrolled in the pro­ In addition, the following five gram. The CSC will mail infor­ register as a donor and receive o plans are available to all Federal chance to win a new color TV. Interview takes place at inter­ mation directly to t hem. mission, Library of Congress con­ employees who are members or certs. who become members of the spon­ Professor Perkins Delivers soring organizations: American Federation of Gov­ 2nd Black Studies Lecture Studies Need Blood Samples ernment Employees Health Bene­ From Black NIH Employees The ,second lecture in the two­ fit Plan; Alliance Health Benefit Blood samples from black 'J)art Illustrated Black Studies Cul­ Plan; American Postal Workers NIH employees with normal tural Series will be given this Union Plan; Government Employ­ blood pressure are ,needed for coming Friday, Nov. 1'2, at 12 ees Hospital Association Benefit use in conjunction with on­ noon in the OC Jaek Masur Audi­ Plan, and Mail Handlers Benefit going studies on high blood Plan. torium. pressure (hypertension). Louis R. Perkins, Adjunct For eligible employees residing The Experimental Thera­ within the prescribed geographi­ Professor of Black S,tudies at Fed­ peutics Br an ch, National eral City College, will ,discuss "The cal area, enrollment is available in Heart and Lung Institute, is group practice prepayment plan, Black American - Who? What? requesting bl o o d samples How? Why?" Columbia Medical Plan of Colum­ from men and women over bia, Md. Mr. •Perkins was formerly 35 years old. It will pay each science advisor for AID in Ethi­ For the contract year which be­ donor $2 for the sample and gins this January the benefits for opia. He served there for 3 will also check his blood pres­ years and counseled the Ministry all plans will be the same as in sure. the current 1971 plan brochures. of Public Health in that country. Interested e m p I o y e e s Charles E. Leasure, Jr., has been op, His first lecture was on "Ethi­ Premiums for many plans will be pointed administrative officer for the should call Ext. 63175 or increased January 1972. opia-Land of Haile Selassie." come to Bldg. 10, Room 7N- Chemotherapy Program, National Can• T he lectures are sponsored !by 262, Monday through Friday, Because of President Nixon's cer Institute, He came to NIH in 1965; Federal City College and Upward 8:30, a.m. to 5 p.m. Economic Stabilization Pro­ joining the Personnel Management MobiHty College at NIH. gram an information pamphlet, Branch, and transferred to NCI in 1966, THE NIH RECORD November 9, 1971 Page 3 PEF Helps Many Ways; Dr. Paul Dudley White, Exercise Advocate, Do You r Part, Donate Speaks Nov. 18 About His Visit to China To Plan Named Davis Dr. Paul Dudley White, noted heart specialist, will discuss his recent Ten percent of the seriously ill visit to the Chinese mainland on Thursday, Nov. 18, at 7:30 p.m. in the patients who are admitted to the Jack Masur Auditorium, Clinical Center. Clinical Center for research stu­ His talk will coincide with the National Advisory Heart and Lung dies need some type of financial Council meetings at NIH. assistance, during their stay, ac­ This past September, Dr. Dr. D. E. O'Keefe Dies, cording to John Roatch, chief of White, and other doctors from the the CC Social Work Department United States, were guests of the Former CC Dept. Chief and administrator of the Patient Chinese Medical Association dur­ Dr. Daniel E. O'Keefe, former Emergency Fund. ing their 12-day visit. chief of the Clinical Center Social He explained that because of Dr. White, a medical pioneer Work Department, died ,in Hous­ catastrophic medical and hospital whose career has spanned an ton, Tex., Oct. 25. expenses many patients have ex­ historic era in cardiology, has been He had been Dean of the School hausted their life savings. active for over 60 years in re­ of Social Work at the University This year more than 500 pa­ search, teaching, clinical medicine of Houston for the past 4 y-ears. tients and their relatives will re­ and public service. Earlier he 1heid similar posts a·t quire emergency financial help. His scientific writings include Michigan State University and This help will be available as more than 700 papers and nine Stanford University Sc'hool of long as NIH employees continue books, and many of them are con- Me•dicine. their contributions to the Pa­ During his 9 years at NIH NIAID's Extramural Programs scored a tient Emergency Fund. (1952-1961), Dr. O'Keefe devel­ touchdown in its Combined Federal During the holiday season many oped the Center's Social Work Campaign. Conducting the CFC pro• employees contribute through the gram with its own posters, the West• Depar,tment ,to meet the needs of wood office has already reached its Davis Plan; employees agree not patiernts in the Nation's first 100 percent participation goal. A $25 to exchange holiday greeting large medical center designed ex­ Savings Bond-donated for a drawing cards with other personnel, in­ clusively for research. held Oct. 29 for all early NIAID con, stead they contribute card and Dr. O'Keefe, a member of the tributors-was won by J·o Anne Stes• postage savings to the Fund. PHS Commissioned Corps, served ney, an EP program analyst. Most of the contributions are in the U.S. Army during World used for patients who may find War II. R&W Women's Golf Ass'n themselves without fuQ.ds. He was buried in the Gettys­ Awards Prizes at Banquet Relatives Helped burg (IPa.) National Cemetery. Dr. O'Keefe is survived by his Often, patients' relatives may The R&W Women's Golf Asso­ wife, Eleanor, and 3 children. 1 need help meeting living costs in ciation at NiiH recently met for their annuaI banquet and presen­ this area. Recently a social work­ after that I acted as consultant." er found a young patient and his tation of prizes-merchandise cer­ Dr. White's efforts have con­ tificates-to the golfers winning parents sleeping in their car in a tributed to the creation and de­ CC parking lot. the highes,t percentage of games velopment of many national and in their group. The patient had an appoint­ Dr. White, whose career has spanned an historic era in cardiology, has international cardiology soci­ The winner,s were Jean Russell, ment at the outpatient clinic the helped establish national and inferno• eties. Shirley ,Everts, and Jeanne Wal­ following morning and they could tional societies in that branch of He was instrumental in the es­ ton. not afford to stay at a motel. medicine. tablishment of the inter-Ameri­ Registration for the Association The social worker arranged for can Society of Cardiology and the usually ibegins in late winter. a motel and NIH employees, sidered classics in the cardiovas­ cular field. Recently, his auto­ International Society of Cardio­ During the spring, once their through PEF, helped provide logy, and has served as president handicap is established, each money for the room and meals. biography, My Life and Medicine, was published. of the latter society and the In­ golfer ~•s assigned ,to a group and Davis Plan contributions help out ternational Cardiology Foundation. must play a miniimum of four with other vitally important needs. Dr. White has helped plan and direct Federal heart programs Dr. White is the cardiologist matches rto qualify for a prize. Although Clinical Center pa­ who was called in as consultant Matches are played at the Falls tients are normally expected to from the time that the National Heart and Lung Institute was on the occasion of President R-oad !Golf Course in ·Potomac, pay their own transportation ( S ee DR. WHITE, Page 8 ) M'd. costs, PEF is often used to help first conceived. out in emergencies. He was Chief Medical Advisor Last year, more than $25,000 to the National Heart Institute was spent to assist patients, Mr. from its inception in 1948 Roatch explained. This year's through 1955. expenditures will be even greater. When asked to serve in 1948 as NIH employees can help now by Executive of the newly formed contributing to the PEF through National Advisory Heart Council, the Davis Plan. Dr. White accepted quite reluct­ antly, admitting that he was, "like Dr. James 0 . Davis Receives most New Englanders, suspicious 1971 Sigma Xi Research Award of Government activity in civilian fields. Dr. James 0. Davis, formerly hea'd of the Exper-imenital Cardio­ "To my surprise," he states in vascular Disease Section, National his new autobiography, "I was Heart Institute, received the quickly convinced that it was a Sigma Xi Research A ward for duty and an opportunity, a really 1971. wonderful opportunity, in which Dr. Davis, who is noted for his I should become involved. . . . research on heart failure and hy­ "Thus I became Executive Di­ pertension, is p r o f e s s o r and rector of the National Advisory Five librarians joined the ,National library of Medicine in September for one chairman of the Department of Heart Council for t he next four year of postgraduate training in the NLM Associate Program. They are (I to r): P 1hysiology at rthe 1School of Med­ years, and at the end of that Dr. Clair Webster Gudmundsen, Jinnet Fowles Lewis, Arlene Marie Aufderheide, i·cine, University of Missouri. period served for another two, and Paula Meise, and Dr. Joseph A. Vignone. Page 4 THE NIH RECORD

Renovated and I

Eye Clinic For:

For Vision Res1

The Schiotz readings are compared with those taken with an applanation Electronic Schiotz tonography is performed by nurse-technician Lessie McCain. tonometer. This continuous measurement of the ease with which fluid leaves the eye is an important procedure in the diagnosis of glaucoma.

The completely renovated and newly equipped Eye Clinic of the National Eye Institute is the foundation for the Institute's expanded clinical vision research program. The Clinic permits thorough diagnostic evaluation of NEI patients, as well as those referred for consultation by other Institutes ranging from simple tests of visual acuity to sophisticated measurements of retinal func­ tion and ocular blood flow. The Eye Clinic has ·been entirely rede­ signed to handle a greater number of pa-

Dr. John L. Marquardt examines a patient with the slit lamp, which enables microscopic examination, of the anterior portion of the eye including the cornea, lens, aqueous humor, and anterior chamber.

Photos by Ee and Cha,

A fundus camera is used to photograph retinal vessels following an intravenous injection of fluorescein dye, This technique, called fluorescein angiography, demonstrated by photographer Gerald S. Hoover, is one of the major recent A perimeter is used to measure the advances in clinical diagnosis of eye conditions and permits a direct visualization peripheral visual field. of the tiniest retinal blood vessels. November 9, 1971 Page 5

~ewly Equipped ms Foundation earch Program

In electroretinography, a specially de• Using the electroretinograph, Mary J. Hoff views an oscilloscope presentation signed contact lens with implanted of the electrical l'esponse of a patient's eye to a blinking light. electrodes picks up electrical impulses from the light-stimulated retina.

tients for studies of glaucoma, uveitis, genetic disorders of the eye, cataract, corneal disease, vascular conditions, and eye tumors. Because of the close relationship be~ween the Eye Clinic staff and those of the other research Institutes, an informal Open House will be held at the Clinic (Bldg. 10, Room lD-04) tomorrow, Nov. 10, between 2 and 5 p.m. All NIH clinical research personnel are invited along with other interested NIH employees. Refreshments will be served. Dr. Donald Bergsma measures visual acuity while occluding the patient's left eye.

dwin Moodhe rles Gailis

Dr. Marquardt uses the indirect oph• thalmoscope to obtain a brilliantly ii• luminated stereoscopic image of the A special technique to measure pressure in the episcleral veins, developed by entire back of the eye, which is use• NEI Director Carl Kupfer, is shedding light on the normal and diseased mecha• fut in the diagnosis of various condi• nisms of intraocular flow, an important facet of glaucoma research. tions such as retinal detachment. Page 6 November 9, 1971 THE NIH RECORD Dr. William Raub Serves Radiation, Chemotherapy and Statistics CANCER REPORT On WHO's Com:mittee (Continued from Page 1 ) Discussed at Hodgkin's Disease Meeting in whites, a difference particu­ Of Computer Experts larly large between black and National Cancer Institute ,researchers were among the speakers at a white men. symposium for practicing physicians on diagnosing and treating Hodg­ New cancers diagnosed totaled ' kin's disease. The meeting, held in St. Louis 61,409 in this specific population during 1969. recently, was sponso1°ed by the She and Dr. Myers found that ' Cancer Clinical Investigation Re­ the outlook of a woman with the When adjusted to the age dis­ view Committee and the Clinical disease is better than that of a tribution in the U.S., the inci­ Investigations Branch. Members man, and that patients under 50 dence rate is 300 new cancers per of the CCIRC also spoke. do better than those over 50 with 100,000 persons. The current status of radio­ the same stage and type of dis­ Generalized for the entire pop­ therapy, chemotherapy, and com­ ease. ulation, this rate indicates t hat bination therapy and their appli­ Contrary to previously held be­ 610,000 new cancers currently are cation to disease stage and clini­ lief, impairment of the immune diagnosed each year. cal condition of the patient were system of a patient with Hodg­ Male Rate Increases kin's disease, as· measured by sev­ discussed, as well as immunologic The general rate among men in­ considerations. eral tests, does, not adversely af­ fect his chance of surviving if he creased from 280 in 1947 to 304 At a chemotherapy session per 100,000 persons in 1969, while chaired by Dr. Paul Carbone, receives appro:ifriate treatment, Dr. Raub recently served on a WHO Dr. Robert C. Young, NCI Solid the rate among women decreased chief of the NCI Medicine Branch, from 294 to 256 cancers . committee which stressed the import• Dr. George P. Canellos, NCI Tumor Service, reported. ance of medical computing as vital in Solid Tumor Service, reported Data Analyzed The increase among men is due dealing with world health problems. largely to the increase in can­ that four times the rate of com­ In a study of approximately 100 When the World Health- -Or­ }}lete remission ( disappearance of cers of the prostate and lung and previously untreated patients rep­ a lesser increase in cancer of the organization recently held its 1971 all· evidence of, cancer) usually resenting all four stages of Hodg­ Consultation on Medical Comput­ achieved in advanced· Hodgkin's colon. kin's, long-term data were ana­ The overall decrease in women ing in Geneva, Switzerland, Dr. disease has occurred in a group lyzed by him and his colleagues. William F. Raub was the only of 43 patients treated with a is due to a drop in cancer of the The data refute the r esults of uterine cervix, stomach, and rec­ American invited to serve on its four-drug combination at the Clin­ previous short-term studies which Advisers Committee. ical Center between 1964 and 1967. tum. indicated a correlation between Lung cancer in women increased Other medical computer experts Drugs listed the length of survival and a pa­ on the WHO committee were from 6 to 12 cancers per 100,000 The drugs are vincristine, pro­ tient's response to immunologic persons between 1947 and 1969. from France, Sweden; West Ger­ tests that measure reactions to many, and England. carbazine, prednisone, and an Planned for completion during alkylating agent-either nitrogen foreign substances. Dr. Raub is chief of the Bio­ Dr. Stephen K. Carter, chief, 1973, the Third National Cancer technology Resources Branch, Di­ m u s t a r d or cyclophosphamide. Survey will analyze statistics for Eighty-one percent of the group Cancer Therapy Evaluation vision of Research Resources. Branch, gave a review of "Single a 3-year period, 1969 through 1971, The committee on which he responded with a complete remis­ in eight cities, two states, and sion; 58 percent of the patients Agent Therapy of Hodgkin's Dis­ served recommended the estab­ Puerto Rico. are still alive with no apparent ease," and Dr. Carbone reported lishment of a Medical Computer on "Considerations Relating to Copies of the short preliminary Information Center through the sign of the disease. Of the complete .. responders, 69 Management of Patients with report for 1969 will be available resources of WHO. Non-Hodgkin's Lymphoma." for distribution in the near future. "Of late, countries all over the percent are still · living without world have been requesting up­ evidence of cancer, suggesting to-date information and data on that complete response to initial Kalberer, Cavanaugh Visit Five European Countries medical computer sy,stems," . ;Dr. combination , drug · therapy_. may Raub reported. · forecast long-term · survival. ' · During a month-long tour of Cavanaugh has been -serving as Radiation Program director for U.S. installations have much to cancer facilities ,in five countries, In reporting the results of a Drs. John T. Kalberer, Jr., NCI's Extramural Activities this offer their counterparts in other · 7-year study of 164 patients with countries, Dr. Raub contends. and Patrick Cavanaugh, will meet past year while on sabbatical leave Hodgkin's disease at the CC, Dr. from Duke University. ·"We have the broadest base of Ralph Johnson, chief, NCI Radia­ with Ministers of Health in Ro­ experience in biomedical comput­ mania, Yugo s I av i a, Hungary, They will examine cancer re­ tion Branch, stated that after search, diagnosis, and therapy as ing of any country," he asserted. preventive radiation treatment ·Czechoslovakia, and Poland. "Our systems for statistical ap­ more than 95 percent of a group Dr. Kalberer is special as­ i•t is conducted within the frame­ work of the national •health sys­ plications, hospital information, of patients whose disease was sistant to the ass·ociate director tems in the five Eastern Euro­ resl?8rch support, signal process­ diagnosed at an early stage have for Extramural Ac,tivities, Na­ pean countries. ing and graphic display are at survived for at least 5 years. tional Cancer Institute, and Dr. tbe forefront of the advanced The study demonstrated that s'tate-of-the-art." best survival and cure rates re­ sulted only when rad i at i on therapy was given both to detect­ DR. McCRUMB ably diseased lymph nodes and to ( Continued fTom Page 1) all other major regions of poten­ national Medicine and Director of tial (although undetectable) in­ the University of Maryland's In­ volvement. stitute of International Medicine Lillian M. Axtell, NCI Bio­ and the Pakistan Medical Re­ metry Branch, explained that sta­ search Center in Lahore. tistical methods applied to factors Since 1967, he was professor of which affect survival in Hodg­ International Medicine, University kin's disease may help to predict of Maryland School of Medicine, a patient's length of survival. engaged in studies on immunity Such predictions help physi­ in smallpox. cians to plan X-ray and drug Dr. McCrumb served as con­ treatment for their patients. Eighte~n Scientific Counselors and Attaches from 15 countries visited NIH Oct. 20. sultant to DBS from 1960 to 1963, Mrs. Axtell and Dr. Max H. Following a luncheon at the Fogarty International Center's Stone Hous-e they and as a member of the Virology _Myers, NCI Biometry Branch, were welcomed by Dr. Robert Q. Marston, NIH Director, and Dr. Milo D. l~avitt and Rickettsiology Study Section, analyzed information on 270 FIC Director. later, they toured the Biomedical Engineering and lnstrumentatio~ NIAID, from 1963 to 1965. patients treated at the CC. Branch, DRS, and the Division of Computer Research and Technology. THE NIH RECORD November 9, 1971 Page 7

Clot Stabilizing Enzyme Dr. H. S. Posner Discusses Is Topic of Conference Prenatal Development In New York, Nov. 18-19 "Protection of Prenatal Develop­ Drs. Koloman Laki and J. W. ment," was discussed by Dr. Her­ Hampton will co-chair a New bert S. Posner at the recent Ninth York Academy of Sciences Con­ National Junior Science and Hu­ ference on the Biological Role of manities Symposium held at the the Clot Stabilizing Enzymes U.S. Military (Transglutaminase, Factor XIII) Academy, West in New York City on Nov. 18-19. .Point, N.Y. Dr. Laki is chief of the Labora­ Dr. Posner is a tory of Biophysical Chemistry, phainnacologist in National Institute of Arthritis the Cell Biology and Metabolic Diseases; Dr. Branch, National Hampton is on the staff of the Irlstitute of En­ Oklahoma Medical Research Foun­ vironmental Health dation, Oklahoma City. Dr. John Sherman (c), NIH Deputy Director, explains the role of the scientist Sciences, Research The conference is supported in administrator at a recent seminar designed to give an in-depth profile and understanding of NIH. Dr. Ronald Lamont-Havers (I), NIH Associate Director for T r i a n g l e Park, part by the Division of Research Research and Training, and Dr. Anthony Bruno, NCI assistant director, sponsor Dr. Posner N.C. Grants. the Staff Training-Extramural Programs monthly workshops. The symposium, sponsored by The clot stabilizing enzyme is the Army Research Office in Dur­ an important, fairly recent dis­ ham, N.C., is held at West Point covery, and is involved in hemo­ Dr. Graykowski Named DR. EISEN and Research Triangle Park on stasis, wound healing, and ather­ Chief of Oral Medicine, ( Continued from Page 1) alternate years. osclerosis. and Medicine. Dr. Posner explained that ap­ Other NIH investigators on the Surgery Branch, NIDR NIH has presented the Jules proximately 2.5 to 3 percent of program are: Judith A. Farrell Freund Memorial Seminar annual­ infants have a malformation at Dr. Edward A. Graykowski has and Dr. Jules A. Gladner, ly since 1961 in •honor of the first· birth. NIAMD; Dr. John S. Finlayson, been appointed chief of the Oral The incidence may be as high Medicine and Surgery Branch of chief of the National Institute of DBS; Sidney T. Yancey, Jr., NCI; Allergy and Infec,tious Disea•ses' as 8 percent if special tests and Drs. Soo 11 Chung and John E. the National Institute of Dental minor anomalies are included. Research. Laboratory of Immunology.. Folk, NIDR; Dr. Yumiko Nagai, Past speakers have included Problems may be related to Marjorie P. Peyton, ~nd Dr. John He succeeds Dr. Drs. Harry Eagle, Albert Sabin, genetic and environmental factors J. Pisano, NHLI. George E. Garring­ Rene Dubos, and Elvin A. Kabat. or genetic predisposition made On the first day of the con­ ton, the Dental In­ manifest by an environmental in­ ference, the NIH color motion stitute's deputy di­ fluence. picture, "To Seek, To Teach, To rector for Intra­ 'A Lady Called Camille' Aims of current studies are: Heal," will be shown. m u r a 1 Research Slated as November Movie • Safety testing - attempt to ( Clinical Investi­ The Employee Health identify problem areas before they gations), who has Service and the Emergency arise, SICKLE CELL been acting chief ( Continued from Page 1) Preparedness Branch, ODA, • Diagnosis - suggest either of the Branch. appropriate sources of therapy will jointly present "A Lady abortion under specific circum­ Dr. Graykowski, Called Camille" as the No­ and followup care, and 5) acquisi­ Dr. Graykowski an oral surgeon stances or tion of detailed data on methodol­ vember movie. • Allow thereapeutic interven­ whose clinical research has fo­ The 29-minute color film is tion where possible, and ogy. cused on the etiology and treat­ an on-the-scene documentary • Prevention intervention • That $1.5 million be allocated ment of aphthous stomatitis, has for basic and applied biomedical of the devastating hurricane, control of interacting factors to served for the past 5 years as Camille, which hit the U.S. prevent abnormal development research into the nature and Medical Director of the NIDR treatment of sickle cell disease. in August 1969 with winds in under a variety of conditions. Unit at the PHS Hospital, San excess of 190 miles per hour The committee further recom­ Francisco. mended: and tides over 20 feet. After earning his D.D.S. and Thousands were saved be­ Dr. Bernardo Houssay Dies; Information Needed M.D. degrees from Marquette Uni­ cause rescue teams and vol­ • That educational and infor­ versity, Dr. Graykowski held sev­ unteer groups, as well as the Long-Time NIAMD Grantee mational materials be prepared, eral posi,tions as an oral surgeon military, were prepared. Was Nobel Prize Winner tested, and made available with 1bhe Air ·Force. The movie will be shown through a centralized clearing In 1961 he joined the staff of at the Westwood Bldg., Con­ Dr. Bernardo A. Houssay, the house for sickle cell disease in­ NIDR. ference Room D, Thursday, first South American ,scienti,st to formation. Nov. 18, at 1:15 and 2 p.m., win the Nobel Prize and a long-, time grantee of the National In­ • That training of black physi­ and in the CC Jack Masur stitute of Arthritis and Metabol­ cians, scientists, and allied health The National Heart and Lung Auditorium, Friday, Nov. 19, Institute was assigned responsi­ at 11:30 a.m. and 12:15 p.m. ic Diseases, died in Buenos Aires, personnel in all aspects of sickle Sept. 21. cell disease be encouraged. bility for coordinating the joint efforts of government agencies, In 1947 Dr. Houssay won the • That the Department of De­ and Dr. Robert L. Ringler, cell disease or active in black Nobel Prize for r,esearch on the fense screen all black recruits for community programs. role of pituitary hormones in sickle cell disease. deputy director, NHLI, was des­ ignated coordinator of the SCD The disease, the most common sugar metabolism. • That a survey of Federal Program. inherited disorder in the U. S., is He held three different re­ programs be conducted for the believed to be present in more than The NHLI appropriation con­ sear,ch grants from NIAMD, be­ purpose of identifying those that 2 million black U.S. citizens. tween 1949 and 1964, concerning offer potential for assisting the tains the FY 1972 funds earmark­ Current methods of treatment ed for this special program, but the role of endocrine glands in Sickle Cell Disease Program in are aimed primarily at alleviating metabolic and pathologic condi­ achieving its goals. some of these funds may be made the pain. available to other agencies to tions of diabetes and hyperten­ In his February health message However, new forms of treat­ sion. carry out part of the program. to Congress, President Nixon ment may make possible reversal Dr. Houssay was honorary identified sickle cell anemia as a The Sickle Cell Disease Ad­ of the sickling process, thereby president of Argentina's National high-priority target and called for visory Committee is composed of shortening or even preventing the Council for Scientific and Tech­ a $5 million increase in Federal ex­ 11 distinguished professional and sickle cell crises and the resultant nological Research, the country's penditures on the disease during lay leaders especially knowledge­ tissue damage. These must un­ principal scientific institution, un­ the current fiscal year. able about the problems of sickle dergo further development. til ,his death. Page 8 November 9, 1971 TH E NIH RECORD Dr. Louis Miller Heads NIAID Malaria Program Dr. Louis H. Miller, formerly associate professor of Tropical Medicine at Columbia University's College of Physicians and Sur­ geons, has been named -to head a malaria research program in the Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases. • He .will conduct research on the red· blood cell membrane as it is affected by malaria infections. • He will plan and direct re­ search in cooperation with the Fed­ eral Bureau of Prisons, Atlanta. • He will coordinate NIAID's Dr. Robert Q. Marston, NIH Director, leafs through a handy travelers' road atlas presented to him by Dr. David malaria research with that done by F. Johnso.n (c), president of the Credit Union Beard o! Dire~lors on International Credit Union Day-Oct. 21-as Thomas the Laboratory's field station in M. Mannix, CU manager, looks on. NIH employees (right) hned up all day to receive coffee (77 gallons), doughnuts Chamblee, Ga. and work done over­ (200 dozen), and cups (1,500). The NIH Credit Union was established in 1940 and presently has over $16 million in seas. assets available to its members. Dr. Miller received his B.S. degree from Haverford College rin DR. WHITE 1956, his M.D. degree from Patent Branch Institutes New Programs Washington University School of (Continued from Page 3) Medicine in 1960, and his M:S. To Stimulate Development of Inventions Eisenhower's heart attack in degree from Columbia University Through a new program instituted by the Patent Branch, Division of 1955. in 1964. Business and Administrative Law, HEW Office of General Counsel, in­ In his autobiography, Dr. From 1965 to 1967, ·he was with ventors will receive a framed patent display. White reports that he had advised the U.S. Army Medical Corps The certificate includes a reproduction of part of the patent document the President in 1955 against at the SEATO Researcll Labora­ and acknowledgment of the in- running for re-election the fol­ ,tory in Thailand. , ventor's contribution with the De- branch each year. Applications are lowing year; not because of his He became assistant professor partment seal attached. filed on 10 to 15 percent. heart, but because " ... I knew of Tropical Medicine at the College "This program gives the Gov- The Department will normally from previous conversations that of Physicians and Surgeons. ernment employee recognition for file patent applications on only his major aim in life was to pro­ Dr. Miller also served as as­ his invention which he may not those inventions which will be used mote world peace .. . " sistant parasitologist for Colum­ otherwise get," explained Norman in large quantity or which require The search for world peace has bia.JPresbyterian -Medical ,center J. Latker, who heads the Patent Department supervision to insure been a dominant theme of Dr. from 1968 to 1971. Branch. adequate quality control for pub- White's own life and he has also Another new policy permits ex- lie protection. donated his efforts to internation­ elusive licensing of Department- Department Retains Rights al medicine. owned inventions in order to create The Department normally re­ Dr. White is one of the world's an incentive for their further de- tains exclusive rights to all in­ most renowned proponents of phy­ velopment and marketing. ventions developed under grants, sical fitness-and one of its best An exclusive license acts as a contracts, or by employees. examples. However, he is opposed stimulus to attract risk capital An exception occurs in situa­ to making a fetish of exercise. for the development and market- tions where the grantee institu­ He feels that a habit of physi­ ing of inventions owned by the tion has an Institutional Patent cal exercise should be formed Department which otherwise Agreement with the Department. early in life and retained, not might never reach the public. This gives them the first option adopted as fad or fancy in later Drugs Require Testing to acquire patent rights in in- years. This is particularly true of ventions made at the institution Dr. White is a walking en­ thusiast whose aversion to eleva­ drugs which require extensive with grant support. testing and evaluation before they Those institutions which have tors is well known to all who have can be marketed. not entered into that Agreement attempted to keep pace with him Previously, the Department must petition the Department for in his rounds of the NIH campus. granted only non-exclusive li- retention of patent rights on a He is also an eloquent proponent of cycling. censes to its patents, which per- case-by-case basis. Dr. Miller was an NIAID career devel• mitted all licensees to make, use, A patent serves as both a pub- Because of his effective pro­ opment awardee. and sell the inventions. lication of the invention and a motion of reasonable exercise, It was found that non-exclusive means whereby an inventor or his Dr. White was given the 1968 licenses did not always provide assignee can exclude others from Jaycee Award of the President's Drs. Lee, Stevens to Speak sufficient incentive to induce pri- making, using, or selling his in­ Commission for the Promotion of Physical Fitness. vate capital to develop and mark- vention for a limited time. At History of Med. Society et inventions. Identifying, evaluating, and NIH personnel and their famil­ The Washing ton Society for the protecting Department-owned in- ies are invited to attend Dr. History of Medicine will hoM a The new licensing policy means ventions are the main functions White's lecture on China. meeting this Thursday, (Nov. 11), that the Department is involved of the Patent Branch, although li­ at 8 p.m., the Billings Auditorium, in patenting inventions for two censing of inventions is becoming tion only in the country issuing National Library of Medicine. reasons-to prevent others from increasingly important. the patent. Dr. Thomas C. Lee, associate profiting from Department- Foreign rights to an invention The Patent Branch 1·eceives in­ professor of Surgery, Georgetown sponsored research, and to offer may be waived to the inventor by ventions which encompasss all of University School of Medicine, an inducement for the develop- the Department upon request. the biomedical sciences. and Dr. Harold Stevens, profes­ ment of inventions to the point of This gives the inventor the right Recent requests for patents in­ sor of Neuro!ogy, George Wash­ practical application. to file patent applications in clude heart assist, non-thrombo­ ington University School of Med­ Approximately 350 reports on foreign countries of his choice at genic, and artificial kidney de­ icine, will speak at the meeting, inventions resulting from sponsor- his own expense. vices, as well as apparatus to im­ which is open to visitors. ed research are received by the A patent protects the inven- prove tissue culture techniques.