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M/S. Ishanga Life Science Pvt. Ltd. ANNEXURE- I

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M/S. Ishanga Life Science Pvt. Ltd. ANNEXURE- I M/s. Ishanga Life Science Pvt. Ltd. Madhvas, Tal. Kalol, Dist.: Panchmahal ANNEXURE- I PROPOSED TERMS OF REFERENCE As per standard ToR of organic manufacturing sector issued by MoEF&CC. M/s. Jyoti Om Chemical Research Centre Pvt. Ltd., Ankleshwar. 1 M/s. Ishanga Life Science Pvt. Ltd. Madhvas, Tal. Kalol, Dist.: Panchmahal ANNEXURE-II LIST OF DIRECTORS Sr. No. Name of Directors Residential Address Contact no. 1. Mr. Ramlal Maru 33,34-Narmada Nagar, Kanjari Road, Halol 9825033071 2. Mr. Jigar Maru 33,34-Narmada Nagar, Kanjari Road, Halol 9722221941 3. Ms. Tanvi Tank C-25/26, Uma society, Kanjari Road, Halol 9619680061 4. Ms. Avani Bhattacharya B-302, Surya Kiran Society, Charwada Road, Vapi 7715086528 M/s. Jyoti Om Chemical Research Centre Pvt. Ltd., Ankleshwar. 2 M/s. Ishanga Life Science Pvt. Ltd. Madhvas, Tal. Kalol, Dist.: Panchmahal ANNEXURE-III PLAN LAY OUT M/s. Jyoti Om Chemical Research Centre Pvt. Ltd., Ankleshwar . 3 M/s. Ishanga Life Science Pvt. Ltd. Madhvas, Tal. Kalol, Dist.: Panchmahal ANNEXURE- IV LIST OF PRODUCTS WITH PRODUCTION CAPACITY Sr. Capacity End usage in mfg Name of Products CAS No. No. (MT/Month) following bulk drug 1 5-Nitrofurfural diacetate 92-55-7 3 Nitrofurantoin 2 1 amino hydantoin 2827-56-57 3 Nitrofurantoin Phosphoryl choline chloride, calcium 3 72556-74-2 7 Citicoline salt 4 Citicoline (CTS) tech 33818-15-4 5 Citicoline 2-(4-Aminopentyl (ethyl) amino) Hydroxy chloroquin 5 69559-11-13 10 ethanol sulphate Solesenacin & 6 3-Quinuclidinone 3731-38-2 10 pemilin 1-Ethyl-3-(3-Dimethylaminopropyl) Intermediate for 7 25952-53-8 15 Carbodimide Hydrochloride Gliptin Series API Ketoprofen 8 3-(1-Cyanoethyl) Benzoic Acid 5537-71-3 15 intermediate 1-(p-methoxy benzyl)- Dextromethorphan 9 1,2,3,4,5,6,7,8,Octahydro iso quinaline- 30356-07-1 8 hydrobromide S-octa base Dextromethorphan 10 Dextrometharphin free base 6700-34-1 8 hydrobromide Cis-2-(2,4-Dichloro phenyl)-2-(1H- 1,2,4-triazol-1-yl-methyl)-1,3- 11 67914-86-7 10 Itraconazole dioxolan-4-yl methyl methane sulfonate- cis-2-(2,4-Dichloro phenyl)-2-(1H- 1,2,4-triazol-1-yl-methyl)-1,3- 67914-86-7 12 8 Itraconazole dioxolan-4-yl methyl methane sulfonate - CRUDE Phenyl (1h pyrrole-2-yl)methanone – 13 136116-84 10 Ketorolac tricarboxylate crude (-)-1-[(4-Chlorophenyl)phenylmethyl]- 14 4-[(4-methylphenyl) sulfonyl] 163837-56-7 6 Levocetrizine piperazine 15 p-Chloro benzhydryl piperazine 303-26-4 6 Levocetrizine M/s. Jyoti Om Chemical Research Centre Pvt. Ltd., Ankleshwar. 4 M/s. Ishanga Life Science Pvt. Ltd. Madhvas, Tal. Kalol, Dist.: Panchmahal Sr. Capacity End usage in mfg Name of Products CAS No. No. (MT/Month) following bulk drug 2,3 pyrridine Benzyle carboxylate 16 151213-40-0 5 Moxyfloxacin Hydrate Chloro compound 3,4-dimethoxy-2-chloro methyl 17 169905-10-6 10 Pentaprozole pyridine 18 pentaprozole sulphide 102625-64-9 10 Pentaprozole 19 Pregabalin (Racemic) 148553-50-8 8 Pregabalin 11-Piperazinyl-dibenzo(b,f) (1,4)- 20 111974-74-4 8 Quetiapine thiazepine hydrochloride 11-[4-[2-(2-Hydroxy ethoxy) ethyl]-1- 21 piperazinyl] dibenzo (b, f) (1, 4) 111974-72-2 8 Quetiapine thiazepine hemifumarate 2-[(4-(3-methoxypropoxy)-3-methyl- 22 2-pyridinyl)methyl]thio]-1H- 117977-21-6 10 Rabeprazole benzimidazole 2-[4-(3-methoxypropoxy)-3-methyl-2- 23 pyridinyl]methyl]sulfinyl]-1H- 117977-21-6 10 Rabeprazole benzimidazole Total ---- 193 ---- M/s. Jyoti Om Chemical Research Centre Pvt. Ltd., Ankleshwar. 5 M/s. Ishanga Life Science Pvt. Ltd. Madhvas, Tal. Kalol, Dist.: Panchmahal ANNEXURE – V LIST OF RAW MATERIALS WITH CONSUMPTION QUANTITY Sr No Raw Material CAS No. Capacity (MT/Month) 1 Cyclohexane Ethylamine 3399-73-3 7.00 2 Methane sulfonyl chloride 124-63-0 3.58 3 Sodium hydroxide 1310-73-2 7.02 4 1,2,4-Triazole 288-88-0 7.00 5 2,3 pyrridne dicarboxylic acid 89-00-9 6.40 6 2,3-Dimethyl-4-nitropyridine N-oxide 37699-43-7 8.40 7 2-Aminodiphenyl sulphide 1134-94-7 4.70 8 2-Bromo butane 78-76-2 11.10 9 2-chloro ethanol 107-07-3 2.60 10 2-Chloroethoxy ethanol 628-89-7 6.79 11 2-furaldehyde diacetate 92-55-7 61.20 12 2-mercapto benzimidazole 583-39-1 11.40 13 2-Propanone 110-20-3 11.88 14 3-Methoxy Propanol 1589-49-7 5.46 15 104-01-8 7.00 4-[4-[4-(4-methoxy phenyl)-1-acetic acid 4-[4-[4-(4-methoxy phenyl)-1-piperazinyl]phenyl]- 16 74853-07-9 11.10 3H -1,2,4-triazol-3-one 17 5 difluoro methoxy 2 mercapto benzimidazole 64-19-7 10.91 18 Acetic acid (Fresh+ Recovered) 64-19-7 220.14 19 Acetonitrile (Fresh+ Recovered) 75-05-8 254.44 20 Acetic anhydride 108-24-7 86.17 21 Acetone (Fresh+ Recovered) 67-64-1 216.80 22 Activated Carbon 7440-44-0 0.58 23 Aluminium Chloride 7446-70-0 0.24 24 Ammonia formate 540-69-2 0.02 25 Ammonia solution 7664-41-7 11.20 26 Ammonium Sulphate 7783-20-2 9.44 27 Sulfuric acid 7664-93- 7.15 28 Benzoic Acid 65-85-0 34.00 29 Benzyl amine 100-46-9 8.74 30 Benzyl chloride 100-44-7 8.00 31 Bis 2 chloro ethylene hydrochloride 821-48-7 9.48 32 Bromine 7726-95-6 5.08 33 Calcium Carbonate 1317-65-3 10.78 34 Carbon 7440-44-0 36.39 35 Catalyst (DCC) 538-75-0 9.49 36 Caustic Flakes 1310-73-2 72.72 M/s. Jyoti Om Chemical Research Centre Pvt. Ltd., Ankleshwar. 6 M/s. Ishanga Life Science Pvt. Ltd. Madhvas, Tal. Kalol, Dist.: Panchmahal 37 Chloro- 2- Pentanone 5891-21-4 18.20 38 67-66-3 1227.10 Chloroform (Fresh+ Recovered) cis-[(2-bromomethyl)-2-(2,4-dichlorophynyl)-1,3- 39 61397-56-6 20.00 dioxolan -4-yl methyl] benzoate 40 Cyclo hexynyl ether 78917-92-7 5.25 41 Cytidine Monophospahte (CMP ) 67-63-6 7.20 42 Di ethyl Malonate 105-53-3 15.58 43 Di Methyl Carbonate 616-38-6 51.00 44 Di n Propyl amine 142-84-7 565.50 45 Dichloromethane 75-09-2 350.78 46 Diiso propyl ethyl amine 36340-89-3 11.62 47 Dimethyl formamide 68-12-2 62.13 48 Dimethyl Malenate 108-59-8 10.56 49 Dimethyl sulfoxide 67-68-5 44.40 50 Dimethyl sulphide 75-18-3 9.00 51 D-Mandalic acid 611-71-2 6.05 52 DMF 68-12-2 18.92 53 D-tartaric acid 147-71-7 4.00 54 EDC (Fresh+ Recovered) 25952-53-8 124.80 55 Ethanol 64-17-5 50.40 56 Ethyl acetate (Fresh+ Recovered) 141-78-6 212.65 57 Ethyl chloro formate 541-41-3 8.58 58 Ethyl Chloro acetate (Fresh+ Recovered) 105-39-5 286.00 59 Ethyl Cyano acetate 105-56-6 5.98 60 Ethyl Formate 109-94-4 12.75 61 Ethyl Piperidine Carboxylate 1126-09-6 14.30 62 Ethylisothiocynate 542-85-8 14.70 63 Formaldehyde 50-00-0 67.08 64 Fumaric acid 110-17-8 3.40 65 Hcl (Fresh+ Recovered) 7647-01-0 147.25 66 Hydrazine Hydrate 10217-52-4 14.10 67 Hydrobenzoic acid 99-96-7 7.47 68 Hydrobromic acid 10035-10-6 38.27 69 Hydrogen Gas 1333-74-0 46.40 70 Hydrogen peroxide 7722-84-1 7.03 71 Hyflow 61790-53-2 1.66 72 Ice 7789-20-0 23.00 73 IPA 67-63-0 11.68 74 Iso Propyl HCL 51639-49-7 0.60 75 Isovelaraldehyde 590-86-3 4.41 76 L+tartaric acid 526-83-0 15.05 77 Liquod Ammonia 1336-21-6 36.20 M/s. Jyoti Om Chemical Research Centre Pvt. Ltd., Ankleshwar. 7 M/s. Ishanga Life Science Pvt. Ltd. Madhvas, Tal. Kalol, Dist.: Panchmahal 78 Maltol 118-71-8 9.00 79 MDC (Fresh+ Recovered) 75-09-2 655.27 80 Megnesium acetate 142-72-3 8.80 81 Megnesium oxide 1309-48-4 5.28 82 Methanol (Fresh+ Recovered) 67-56-1 2014.07 83 Methanolic Ammonia 1336-21-6 18.20 84 Methanolic Hcl 7647-01-0 7.20 85 Methyl Chloroacetate 96-34-4 2.21 86 Methylene chloride 75-09-2 49.28 87 Morpholine 110-91-8 10.96 88 N, N-Dimethylaniline 121-69-7 1.66 89 N,N Dimethyl-1,3-Propanediamine 109-55-7 294.00 90 NaoH flakes 1310-73-2 7.70 91 N-Ethyl ethanol amine 110-73-6 22.75 92 n-Heptane 142-82-5 28.20 93 N-Hexane 110-54-3 13.43 94 Nitric acid 7697-37-2 8.85 95 Nitrogen gas 7727-37-9 3.22 96 N-methyl pyrrolidinone 872-50-4 13.58 97 Orgno Copper Catalyst 7440-58-8 0.91 98 Palladium carbon 5/3/7440 1.74 99 Parachloro benzo phenon 134-85-0 10.00 100 Phenylchloroformate 1885-14-9 4.38 101 Phosphorous Oxychloride 10025-87-3 17.34 102 Phosporic acid 7664-38-2 64.80 103 Phosporous pentaoxide 1314-56-3 28.19 104 Piperazine 110-85-0 5.17 105 Pocl3 10025-87-3 42.80 106 Poly phosphoric acid 8017-16-1 22.75 107 Potassium 7440-09-7 9.90 108 Potassium carbonate 584-08-7 72.30 109 Potassium Hydroxide 1310-58-3 14.86 110 Potassium Tert- Butoxide 865-47-4 5.72 111 Propanone - 67-64-1 3.78 112 PTSC 98-59-9 7.83 113 Pyridine 110-86-1 0.89 114 Pyrrole 109-97-7 46.00 115 R-(+) ∞ Phenyl ethyl amine 3886-69-9 5.77 116 Raney Nickel 12003-78-0 7.28 117 Side Chain (Phosporyl Choline chloride) 4826-71-5 18.00 118 Soda ash 497-19-8 26.44 119 Sodium bi carbonate 144-55-8 2.44 120 Sodium carbonate 497-19-8 7.67 M/s.
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