DOCSLIB.ORG

SYMPOSIA for Research Studies

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
SYMPOSIA for Research Studies The Journal of Prevention of Alzheimer’s Disease - JPAD© Volume 2, Number 4, 2015 APOE genotyping as an additional resource to help with recruitment SYMPOSIA for research studies. Also in 2015, a Researcher Portal will be launched which will allow the Registry to provide additional reporting S1 - PROSPECTIVE READINESS COHORTS, INTERNET- metrics that assess its impact on accelerating enrollment into studies.. BASED REGISTRIES AND MATCHING SERVICES FOR ALZHEIMER’S DISEASE CLINICAL TRIALS. MICHAEL Communications 3: Brain Health Registry, Michael W. Weiner1 ((1) WEINER, JESSICA LANGBAUM University of California San Francisco (UCSF), San Francisco, CA, USA)) The overall goal of this Symposium will be to present updated information concerning the development, use, and progress of based The goal of the internet-based Brain Health Registry registries and matching services to recruit participants and direct them (BrainHealthRegistry.org) is recruitment, assessment, and longitudinal to participate in Alzheimer’s disease clinical treatment trials. There monitoring of subjects for clinical neuroscience studies of all types, will be four presentations from different programs. especially Alzheimer’s disease studies. The Brain Health Registry is not specific for Alzheimer’s disease, but aims to facilitate all types of Communications 1: Alzheimer’s Association TrialMatch. Maria C. neuroscience research. Subjects are recruited to the site by a variety Carrillo1, Keith Fargo1, Beth Kallmyer1 ((1) Alzheimer’s Association of marketing/advertising/public relations methods. Subjects provide National Organization, USA) informed consent (approved by UCSF IRB). Subjects complete an extensive battery of self-report questionnaires and take on line The Alzheimer’s Association’s TrialMatch program is an internet- neuropsychological tests. Subjects who meet specific criteria are based matching service that connects people with clinical studies informed that studies are taking place at clinics in their area, and are on Alzheimer’s disease and other causes of cognitive impairment. provided with contact information to enroll in studies. Thus far, more The program includes a continuously updated database of clinical than 22,000 have joined and 6-month return rate is approximately trials and observational studies from across the entire spectrum of 50%. human-participant studies—including studies for people with disease, their caregivers, and healthy controls of all ages—which includes Communications 4: Cognitive Health in Ageing Register: enrollment criteria and study sites. Currently, the database consists of Investigational, Observational and Trial studies in dementia more than 1,100 study/site combinations. TrialMatch users complete a research – Prospective Readiness cOhort (CHARIOT-PRO). Michael brief profile (more than 100,000 to date) including demographics and T. Ropacki1,2, H. Michael Arrighi1, Robert Perneczky3, Josip Car3, health questions, and the responses are compared to the enrollment Lefkos Middleton3 ((1) Janssen R&D, Fremont, CA, USA; (2) Loma criteria and locations of the studies in the database to provide Linda University School of Medicine, Neurology, Loma Linda, CA, individualized matches, including lay language summaries and contact USA; (3) School of Public Health, Imperial College London, London, information for all matched studies. UK)) Communications 2: Alzheimer’s Prevention Registry. Jessica The CHARIOT-PRO program leverages participants from the B. Langbaum1, Nellie High1, Paul S. Aisen2, Marilyn S. Albert3, CHARIOT Registry at Imperial College London. In the first three Meryl Comer4, Jeffrey L. Cummings5, Jennifer J. Manly6, Ronald years, the CHARIOT Registry enrolled approximately 25,000 C. Petersen7, Reisa A. Sperling8, Gabrielle Strobel9, Michael W. volunteers over the age of 60 without dementia, recruited from the Weiner10, Eric M. Reiman11, Pierre N. Tariot1 ((1) Banner Alzheimer’s surgeries of General Practitioners in the London area. CHARIOT- Institute, Phoenix, AZ, USA; (2) Alzheimer’s Disease Cooperative PRO is a single center prospective readiness cohort study of Study, University of California San Diego, San Diego, CA, USA; approximately 700 participants self-referred or recruited from the (3) Department of Neurology, Johns Hopkins University School of CHARIOT Registry who will be followed for up to 4 years. The Medicine, Baltimore, MD, USA; (4) Geoffrey Beene Foundation goals of CHARIOT-PRO are to better understand the natural history Alzheimer’s Initiative, Washington, DC, USA; (5) Cleveland of cognitive and functional changes in participants at risk for mild Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA; cognitive impairment due to Alzheimer’s disease, as well as to develop (6) Department of Neurology, Columbia University College of a well-characterized, longitudinally followed prospective readiness Physicians and Surgeons, New York, NY, USA; (7) Department cohort for future early Alzheimer’s disease clinical trials. Participants of Neurology, Mayo Clinic, Rochester, MN, USA; (8) Department undergo a series of neuropsychological evaluations to characterize the of Neurology, Harvard Medical School, Boston, MA, USA; (9) patterns of cognitive change and their inter-relationship in the earliest Alzforum, Cambridge, MA, USA; (10) Department of Radiology and stages of cognitive impairment. In addition, how changes relate to the Biomedical Engineering, University of California San Francisco, San clinical presentation of cognitive impairment of the Alzheimer’s type Francisco, CA, USA) will be evaluated over time. An opportunity is possible to identify and characterize individuals with different likelihoods of progressing The Alzheimer’s Prevention Registry (www.endALZnow.org) along different clinical paths, which may form a framework for the was launched in 2012 to provide a shared recruitment resource to evaluation of interventions. In the first nine months of the study, ~ 500 the scientific community in order to facilitate enrollment in participants were enrolled in CHARIOT-PRO. Overall, CHARIOT- Alzheimer’s prevention-related studies and complement and enhance PRO is designed as the largest head-to-head study of clinical outcome local recruitment efforts. To date, more than 113,000 people have assessments collecting real world information regarding prognostic joined, with marketing/advertising/public relations being the primary factors, disease course, functional decline and disease burden on recruitment methods. Enrollees receive regular email communication participants in the earliest stage of disease, that also is developing to keep them apprised of the latest news in Alzheimer’s prevention a well-characterized, longitudinally followed prospective readiness research, as well as email notifications when study opportunities cohort for future early AD clinical trials. become available in their communities. Beginning later in 2015, Registry members will be invited to submit a sample of DNA for 269 S2 - THE LANCET AND THE LANCET NEUROLOGY 86-89. 2. International Monetary Fund World Economic Outlook, SYMPOSIUM ON CLINICAL RESEARCH IN DEMENTIA: April 2015. Where are we headed? Perspectives on potential output. INCREASING VALUE AND REDUCING WASTE. www.imf.org/external/pubs/ft/weo/2015/01/pdf/c3.pdf (accessed April LON S. SCHNEIDER (University of Southern California, USA) 15, 2015); 3. Macleod MR, Michie S, Roberts I, et al. Biomedical research: increasing value, reducing waste. Lancet 2014; 383: 101-4. Communications 1: Towards valuable research design, conduct, and 4. Chalmers I, Bracken MB, Djulbegovic B, et al. How to increase analysis. Malcolm Macleod (Professor of Neurology and Translational value and reduce waste when research priorities are set. Lancet Neuroscience, University of Edinburgh, UK); Communications 2014; 383: 156-65; 5. Ioannidis JPA, Greenland S, Hlatky MA, et al. 2: Tackling waste in the regulation and management of clinical Increasing value and reducing waste in research design, conduct, and trials. Rustam Al-Shahi Salman (Professor of Clinical Neurology, analysis. Lancet 2014; 383: 166-75. 6. Salman RA, Beller E, Kapgan University of Edinburgh, UK); Communications 3: Aims and J, et al. Increasing value and reducing waste in biomedical research priorities of the IMI2 Alzheimer’s Disease Research Platform. regulation and management. Lancet 2014; 383: 176-85. 7. Vaudano E, Elisabetta Vaudano (Principal Scientific Manager & Coordinator, Vannieuwenhuyse B, Van der Geyten S, et al. Boosting translational Innovative Medicines Initiative, Brussels, Belgium) research on Alzheimer’s disease in Europe: The Innovative Medicine Initiative AD research platform. Alzheimer’s & Dementia 2015, DOI: • Panel Discussion: Lon S. Schneider. Panelists: Malcolm Macleod1, http://dx.doi.org/10.1016/j.jalz.2015.02.002 Rustam Al-Shahi Salman1, Elisabetta Vaudano1, Rachel J. Schindler2, Jose Luis Molinuevo3, Sabine Kleinert4, Elena Becker-Barroso2. S3 - UTILITY OF MULTI-MODAL BIOMARKER-ENDPOINT ((1) TBC, Innovative Medicines Initiative; (2) Vice-President, TRIALS IN HIGH-RISK PERSONS TO IDENTIFY Neuroscience Area, Pfizer, New York, NY, USA; (3) Hospital Clinic, CANDIDATE AGENTS FOR AD PREVENTION TRIALS. Barcelona, Spain; (4) Executive Editor, The Lancet, London, UK; MARILYN ALBERT (PhD. Department of Neurology, Johns Hopkins (5) Editor, The Lancet Neurology, London, UK)) University School of Medicine, Baltimore, MD, USA) Prevention and treatment of age-related cognitive impairment Communications 1: Study design
Load more

Recommended publications
  • Accurate Segmentation of Brain MR Images
    Accurate segmentation of brain MR images Master of Science Thesis in Biomedical Engineering ANTONIO REYES PORRAS PÉREZ Department of Signals and Systems Division of Biomedical Engineering CHALMERS UNIVERSITY OF TECHNOLOGY Göteborg, Sweden, 2010 Report No. EX028/2010 Abstract Full brain segmentation has been of significant interest throughout the years. Recently, many research groups worldwide have been looking into development of patient-specific electromagnetic models for dipole source location in EEG. To obtain this model, accurate segmentation of various tissues and sub-cortical structures is thus required. In this project, the performance of three of the most widely used software packages for brain segmentation has been analyzed: FSL, SPM and FreeSurfer. For the analysis, real images from a patient and a set of phantom images have been used in order to evaluate the performance r of each one of these tools. Keywords: dipole source location, brain, patient-specific model, image segmentation, FSL, SPM, FreeSurfer. Acknowledgements To my advisor, Antony, for his guidance through the project. To my partner, Koushyar, for all the days we have spent in the hospital helping each other. To the staff in Sahlgrenska hospital for their collaboration. To MedTech West for this opportunity to learn. Table of contents 1. Introduction ......................................................................................................................................... 1 2. Magnetic resonance imaging ..............................................................................................................
    [Show full text]
  • Freesurfer Tutorial
    FreeSurfer Tutorial FreeSurfer is brought to you by the Martinos Center for Biomedical Imaging supported by NCRR/P41RR14075, Massachusetts General Hospital, Boston, MA USA 2008-06-01 20:47 1 FreeSurfer Tutorial Table of Contents Section Page Overview and course outline 3 Inspection of Freesurfer output 5 Troubleshooting your output 22 Fixing a bad skull strip 26 Making edits to the white matter 34 Correcting pial surfaces 46 Using control points to fix intensity normalization 50 Talairach registration 55 recon-all: morphometry and reconstruction 69 recon-all: process flow table 97 QDEC Group analysis 100 Group analysis: average subject, design matrix, mri_glmfit 125 Group analysis: visualization and inspection 149 Integrating FreeSurfer and FSL's FEAT 159 Exercise overview 172 Tkmedit reference 176 Tksurfer reference 211 Glossary 227 References 229 Acknowledgments 238 2008-06-01 20:47 2 top FreeSurfer Slides 1. Introduction to Freesurfer - Bruce Fischl 2. Anatomical Analysis with Freesurfer - Doug Greve 3. Surface-based Group Analysis - Doug Greve 4. Applying FreeSurfer Tools to FSL fMRI Analysis - Doug Greve FreeSurfer Tutorial Overview The FreeSurfer tools deal with two main types of data: volumetric data volumes of voxels and surface data polygons that tile a surface. This tutorial should familiarize you with FreeSurfer’s volume and surface processing streams, the recommended workflow to execute these, and many of their component tools. The tutorial also describes some of FreeSurfer's tools for registering volumetric datasets, performing group analysis on morphology data, and integrating FSL Feat output with FreeSurfer overlaying color coded parametric maps onto the cortical surface and visualizing plotted results.
    [Show full text]
  • Confrontsred Tape
    IPS: THE MENTAL HEALTH SERVICES CONFERENCE Oct. 8-11, 2015 • New York City When Good Care Confronts Red Tape Navigating the System for Our Patients and Our Practice New York, NY | Sheraton New York Times Square POSTER SESSION OCTOBER 09, 2015 POSTER SESSION 1 P1- 1 ANGIOEDEMA DUE TO POTENTIATING EFFECTS OF RITONIVIR ON RISPERIDONE: CASE REPORT Lead Author: Luisa S. Gonzalez, M.D. Co-Author(s): David A. Kasle MSIII Kavita Kothari M.D. SUMMARY: For many drugs, the liver is the principal site of its metabolism. The most important enzyme system of phase I metabolism is the cytochrome P-450 (CYP450). Ritonavir, a protease inhibitor used for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), has been shown to be a potent inhibitor of the (CYP450) 3A and 2D6 isozymes. This inhibition increases the chance for potential drug-drug interactions with compounds that are metabolized by these isoforms. Risperidone, a second generation atypical antipsychotic, is metabolized to a significant extent by the (CYP450) 2D6, and to a lesser extent 3A4. Ritonavir and risperidone can both cause serious, and even life threatening, side effects. An example of one such rare side effect is angioedema which is characterized by edema of the deep dermal and subcutaneous tissues. Here we present three cases of patients residing in a nursing home setting, diagnosed with HIV/AIDS and comorbid psychiatric illness. These patients were all on antiretroviral medications such as ritonavir, and all later presented with varying degrees of edema after long term use of risperidone. We aim to bring to awareness the potential for ritonavir inhibiting the metabolism of risperidone, thus leading to an increased incidence of angioedema in these patients.
    [Show full text]
  • A Novel Mricompatible Brain Ventricle Phantom for Validation of Segmentation and Volumetry Methods
    CME JOURNAL OF MAGNETIC RESONANCE IMAGING 36:476–482 (2012) Original Research A Novel MRI-Compatible Brain Ventricle Phantom for Validation of Segmentation and Volumetry Methods Amanda F. Khan, MSc,1,2 John J. Drozd, PhD,2 Robert K. Moreland, MSc,2,3 Robert M. Ta, MSc,1,2 Michael J. Borrie, MB ChB,3,4 Robert Bartha, PhD1,2* and the Alzheimer’s Disease Neuroimaging Initiative Purpose: To create a standardized, MRI-compatible, life- Conclusion: The phantom represents a simple, realistic sized phantom of the brain ventricles to evaluate ventricle and objective method to test the accuracy of lateral ventri- segmentation methods using T1-weighted MRI. An objec- cle segmentation methods and we project it can be tive phantom is needed to test the many different segmen- extended to other anatomical structures. tation programs currently used to measure ventricle vol- Key Words: 3T; brain phantom; MRI; ventricle; software umes in patients with Alzheimer’s disease. validation; segmentation Materials and Methods: A ventricle model was con- J. Magn. Reson. Imaging 2012;36:476–482. structed from polycarbonate using a digital mesh of the VC 2012 Wiley Periodicals, Inc. ventricles created from the 3 Tesla (T) MRI of a subject with Alzheimer’s disease. The ventricle was placed in a brain mold and surrounded with material composed of VOLUMETRY HAS DEMONSTRATED that large mor- 2% agar in water, 0.01% NaCl and 0.0375 mM gadopente- phological changes occur in the brain during the tate dimeglumine to match the signal intensity properties course of Alzheimer’s disease (AD) (1). In particular, of brain tissue in 3T T -weighted MRI.
    [Show full text]
  • Medical Images Research Framework
    Medical Images Research Framework Sabrina Musatian Alexander Lomakin Angelina Chizhova Saint Petersburg State University Saint Petersburg State University Saint Petersburg State University Saint Petersburg, Russia Saint Petersburg, Russia Saint Petersburg, Russia Email: [email protected] Email: [email protected] Email: [email protected] Abstract—with a growing interest in medical research problems for the development of medical instruments and to show and the introduction of machine learning methods for solving successful applications of this library on some real medical those, a need in an environment for integrating modern solu- cases. tions and algorithms into medical applications developed. The main goal of our research is to create medical images research 2. Existing systems for medical image process- framework (MIRF) as a solution for the above problem. MIRF ing is a free open–source platform for the development of medical tools with image processing. We created it to fill in the gap be- There are many open–source packages and software tween innovative research with medical images and integrating systems for working with medical images. Some of them are it into real–world patients treatments workflow. Within a short specifically dedicated for these purposes, others are adapted time, a developer can create a rich medical tool, using MIRF's to be used for medical procedures. modular architecture and a set of included features. MIRF Many of them comprise a set of instruments, dedicated takes the responsibility of handling common functionality for to solving typical tasks, such as images pre–processing medical images processing. The only thing required from the and analysis of the results – ITK [1], visualization – developer is integrating his functionality into a module and VTK [2], real–time pre–processing of images and video – choosing which of the other MIRF's features are needed in the OpenCV [3].
    [Show full text]
  • 9. Biomedical Imaging Informatics Daniel L
    9. Biomedical Imaging Informatics Daniel L. Rubin, Hayit Greenspan, and James F. Brinkley After reading this chapter, you should know the answers to these questions: 1. What makes images a challenging type of data to be processed by computers, as opposed to non-image clinical data? 2. Why are there many different imaging modalities, and by what major two characteristics do they differ? 3. How are visual and knowledge content in images represented computationally? How are these techniques similar to representation of non-image biomedical data? 4. What sort of applications can be developed to make use of the semantic image content made accessible using the Annotation and Image Markup model? 5. Describe four different types of image processing methods. Why are such methods assembled into a pipeline when creating imaging applications? 6. Give an example of an imaging modality with high spatial resolution. Give an example of a modality that provides functional information. Why are most imaging modalities not capable of providing both? 7. What is the goal in performing segmentation in image analysis? Why is there more than one segmentation method? 8. What are two types of quantitative information in images? What are two types of semantic information in images? How might this information be used in medical applications? 9. What is the difference between image registration and image fusion? Given an example of each. 1 9.1. Introduction Imaging plays a central role in the healthcare process. Imaging is crucial not only to health care, but also to medical communication and education, as well as in research.
    [Show full text]
  • Segmentation Tools Frederic Cervenansky What Is Open-Source
    Through the forest of open source segmentation tools Frederic Cervenansky What is Open-Source Open source doesn’t just mean access to source code 1 - Free Redistribution (no restriction from selling or giving away the software as a component) 2 - Source Code ( as well as compiled form) 3 - Derived Works (copyleft license) 4 - Integrity of The Author's Source Code (users have a right to know who is the original author) 5 – Distribution of License (no need of a third license) 6 and more What criteria to discriminate software? Usability Code Langage Segmentation methods Plugins – Extensions Organ/structure specificity Software Organs specific Code Segmentation Plugins Citations* Language Methods ImageJ no Java Automatic Yes 723 Fiji No ( Cell) Java Automatic Yes 1254 Freesurfer Brain C++, bash Automatic no 470 ITK no C++ Automatic Yes-no 512 Slicer3D No (Brain) C++ Manual- Automatic Yes 75 FSL Brain C++, bash Automatic No 690 SPM Brain matlab Automatic Yes 7574 pubmed … --- --- --- --- --- *: JAVA Bio-imaging Plugins system User friendly IMAGEJ 2D and 3D limitation No hierarchy in plugins ImgLib (n-dimensional, repackaging, sharing improvement) KMeans Color Quantization Color Picker Fiji Marching IMAGEJ2 Icy Threshold Learning Active Contours Squassh KMeans Clustering Texture Level Set Maximum Entropy Threshold HK-Means Graph Cut Maximum Multi Entropy Threshold Active Cells Bad Indexation: Seeded Region Growing Toolbox dithering as Snake. segmenation tool Brain Organ specific Fully automatic FreeSurfer Allow to restart at divergent steps. Both available Fully automatic through VIP Catalog of tools FSL BET ( Brain Extraction) FAST (GM and WM automated Segmentation). SPM Modified gaussian mixture model Need a matlab license.
    [Show full text]
  • CV Xinwang.Pdf
    Room 310, Ho Sin Hang Engineering Bldg CUHK, Shatin, N.T., Hong Kong H +852 67003439 B [email protected] Xin WANG Í http://tracyxinwang.site Education 2018.10– University of Melbourne , Australia current Melbourne Neuropsychiatry Centre (MNC), Department of Psychiatry Visitng student Supervisor: Professor Andrew Zalesky 2016–current The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China Department of Biomedical Engineering Ph.D. in Electronic Engineering Supervisor: Professor Raymond Kai-yu Tong 2012–2016 University of Electronic Science and Technology of China (UESTC), China School of Communication and Information Engineering B.E. in Communication Engineering Overall GPA: 3.95/4.0; 90.1/100 Ranking: 2/405 Research Interests Computational Using neuroimaging techniques to develop computational models to investigate Neuroscience functional brain networks for neurological disorders Causal Fusion multi-modalities of neuroimaging data (e.g. fMRI, EEG) and develop causal Inference frameworks to infer dynamic structures and patterns in brain functions Research Projects 2017-current Using neuroimaging and computational modeling to customize transcranial direct current stimulation protocols for facilitating hand function recovery after stroke { Develop computational models of neuromodulation for understanding the tDCS- induced changes in brain activation and brain networks in stroke subjects { Simulate the neural dynamics and tDCS effect on lesioned brain. { Identify the optimal stimulation target area from neuroimaging and neurophysio- logical findings to optimize the tDCS delivery target brain region. 1/2 2016-2017 Development of a brain computer interface system with neurofeedback to facilitate the activation of the mirror neuron system for stroke rehabilitation { Characterize brain reorganization during stroke rehabilitation { Analyze multimodal brain imaging datasets to infer changed patterns in brain functions after stroke recovery Publications Wang, X, Wong, W, Sun, R, Chu, CW, Tong, KY.
    [Show full text]
  • Software Tools for the Analysis of Functional Magnetic Resonance Imaging
    Basic and Clinical Autumn 2012, Volume 3, Number 5 Software Tools for the Analysis of Functional Magnetic Resonance Imaging Mehdi Behroozi 1,2, Mohammad Reza Daliri 1* 1. Biomedical Engineering Department, Faculty of Electrical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran. 2. School of Cognitive Sciences (SCS), Institute for Research in Fundamental Science (IPM), Niavaran, Tehran, Iran. Article info: A B S T R A C T Received: 12 July 2012 First Revision: 7 August 2012 Functional magnetic resonance imaging (fMRI) has become the most popular method for Accepted: 25 August 2012 imaging of brain functions. Currently, there is a large variety of software packages for the analysis of fMRI data, each providing many features for users. Since there is no single package that can provide all the necessary analyses for the fMRI data, it is helpful to know the features of each software package. In this paper, several software tools have been introduced and they Key Words: have been evaluated for comparison of their functionality and their features. The description of fMRI Software Packages, each program has been discussed and summarized. Preprocessing, Segmentation, Visualization, Registration. 1. Introduction analysis the fMRI data to extract information about the different stimuli (Matthews, Shehzad, & Kelly, 2006). unctional Magnetic resonance imaging (fMRI), a modern technique of imaging, is a Generated data from fMRI have very large amount. powerful non-invasive and safe tool which The handling, processing, analysis and visualization Downloaded from bcn.iums.ac.ir at 18:01 CET on Friday February 20th 2015 F is used for the study of the function of the of fMRI data are not feasible without computer-based brain based on measure of the brain neural methods.
    [Show full text]
  • Postdoctoral Fellow in Advanced Machine Learning Techniques in Brain Imaging Hurvitz Brain Sciences Program and Physical Science
    Postdoctoral Fellow in Advanced Machine Learning Techniques in Brain Imaging Hurvitz Brain Sciences Program and Physical Sciences at the Sunnybrook Research Institute Departments of Medicine and Medical Biophysics Temerty Faculty of Medicine, University of Toronto PIs: Maged Goubran, PhD Assistant Professor, Scientist Medical Biophysics University of Toronto Sandra Black, MD, FRCP Professor, Director Brain Sciences Neurology University of Toronto Description of the Position: We are seeking a postdoctoral fellow to lead development of novel, machine learning algorithms for the analysis of MRI and microscopy data. The position is with the Sandra Black Centre for Brain Resilience & Recovery, the LC Campbell Cognitive Neurology Research Unit, and the Hurvitz Brain Sciences Program at the Sunnybrook Research Institute. This dynamic and collegial research environment provides opportunities to participate in pioneering techniques that will be used to understand and treat neurodegenerative and neurovascular disease. Current large multi-site studies and trials include the Ontario Neurodegenerative Disease Research Initiative (ONDRI), the Toronto Dementia Research Alliance (TDRA), Brain-Eye Amyloid Memory Study (BEAM), and Medical Imaging Trials Network of Canada-C6 (MITNEC-C6). The position requires working closely with the PIs Dr. Goubran (machine learning, neuroimaging, computational neuroscience), Dr. Black (neurology, small vessel disease, cognition) and with graduate students, imaging analysts and software developers in the lab to develop, improve and apply novel computational approaches to challenging image analyses and patient outcome prediction problems. This will be performed in collaboration with our internal and external international collaborators including neurologists, radiologists, surgeons, psychologists, physicists and computer scientists. There will be opportunities for multiple publications on novel computational tools for dementia, stroke and neuroscience research.
    [Show full text]
  • 3D Slicer Documentation
    3D Slicer Documentation Slicer Community Sep 24, 2021 CONTENTS 1 About 3D Slicer 3 1.1 What is 3D Slicer?............................................3 1.2 License..................................................4 1.3 How to cite................................................5 1.4 Acknowledgments............................................7 1.5 Commercial Use.............................................8 1.6 Contact us................................................9 2 Getting Started 11 2.1 System requirements........................................... 11 2.2 Installing 3D Slicer............................................ 12 2.3 Using Slicer............................................... 14 2.4 Glossary................................................. 19 3 Get Help 23 3.1 I need help in using Slicer........................................ 23 3.2 I want to report a problem........................................ 23 3.3 I would like to request enhancement or new feature........................... 24 3.4 I would like to let the Slicer community know, how Slicer helped me in my research......... 24 3.5 Troubleshooting............................................. 24 4 User Interface 27 4.1 Application overview........................................... 27 4.2 Review loaded data............................................ 29 4.3 Interacting with views.......................................... 31 4.4 Mouse & Keyboard Shortcuts...................................... 35 5 Data Loading and Saving 37 5.1 DICOM data..............................................
    [Show full text]
  • LONI Pipeline Handbook
    LONI Pipeline Neuroimaging Solutions A practical, hands-on guide to using the LONI Pipeline for neuroimaging analysis LONI Pipeline version 7.0.1 Handbook version 1.6 http://pipeline.loni.usc.edu LONI Pipeline training is funded by the National Institutes of Health through NIBIB grant P41EB015922 Contents Getting Started 1 Overview: About LONI Pipeline 1 Benefits 1 Requirements 1 Installation 2 Software Download 2 LONI Cluster Usage Account 2 Platform-Specific Installation 2 OS X 2 Windows 3 Linux/Unix 3 Interface 4 Overview 4 Data Sources & Sinks 6 Overview 6 How-to 6 Find & Replace 7 LONI Pipeline Viewer 8 Overview 8 Beginning Example Workflows 9 Registration Using AIR 10 Image Processing with the Quantitative Imaging Toolkit - Denoising 29 Intermediate Topics 37 LONI Image Data Archive 38 Overview 38 Change Server for Entire Workflow 40 Overview 40 How-to 40 Intermediate Example Workflows 41 fMRI First Level Analyses 42 DTI Analyses 59 DSI Analyses 65 Image Analysis with the Quantitative Imaging Toolkit - Tractography Metrics 73 Advanced Topics 85 Building a Module 86 Overview 86 How-to 86 Optional Actions 87 Required Options 88 Adding additional parameters 90 Specify dependencies and manipulate file names 90 LONI Pipeline Provenance 92 Overview 92 How-to 92 Adding Metadata 95 Overview 95 How-to 96 Conditional Module 98 Overview 98 How-to 98 Distributed Pipeline Server Installation 102 Introduction 102 GUI Installation 102 Command Line Installation 110 Glossary 113 Bibliography 116 Getting Started Overview: About LONI Pipeline The LONI Pipeline is a free workflow application primarily aimed at neuroimaging researchers. With the LONI Pipeline, users can quickly create workflows that take advantage of any and all neuroimaging tools available.
    [Show full text]