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Curriculum Vitae

Edna F. R. Pereira, Ph.D. Associate Professor and Director of Division Division of Translational Toxicology Department of Epidemiology and Public Health University of Maryland School of

Date February 06, 2021

Contact Information

Business Address: Department of Epidemiology and Public Health 10 South Pine St. Suite 900F Baltimore, MD 21201 Business Phone Number: (410) 706-3563 Email: [email protected] Foreign languages: Portuguese (native); Spanish (working knowledge)

Education

1982 B.S., Chemistry, Escola Técnica Federal de Química, Rio de Janeiro, RJ, Brazil (1979-1982)

1987 Pharmacy Professional Degree, Escola de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil (1982-1987)

1989 M.Sc., Pharmacology, Departmento de Farmacologia Básica e Clínica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil (1988- 1989) “Atividade Analgésica-Antiinflamatória de Novos Derivados Pirazólicos” (Analgesic and Antiinflammatory Actvities of New Pirazoles) Advisor: Dr. Nuno Álvares Pereira

1996 Ph.D., Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD, USA (1993- 1996) A Novel Molecular Mechanism of Modulation of the Nicotinic Receptor Activity Advisors: Dr. Edson X. Albuquerque and Dr. Alfred Maelicke

Post-Graduate Education and Training

1996-1998 Post-doctoral fellow Department of Pharmacology and Experimental Therapeutics University of Maryland School of Medicine Mentors: Dr. Edson Albuquerque and Dr. Alfred Maelicke

Pereira, Edna F.R. 2012-2017 Good Laboratory Practice (GLP) Training: Compliance procedures; GLP protocol writing; preparation, review, and maintenance of standard operating procedures; administrative procedures Program in Comparative Medicine University of Maryland School of Medicine Coordinators: Dr. Louis DeTolla and Dr. Rigoberto Sanchez

Professional Licensures

Chemistry (1982) Inactive Rio de Janeiro, RJ, Brazil Pharmacy (1986) Inactive Rio de Janeiro, RJ, Brazil

Employment History

Academic Appointments

1989-1990 Assistant Professor Departamento de Farmacologia e Fisiologia (Dept. Pharmacol. Physiol.) Escola de Medicina de Campos (Medical School of Campos) Campos, RJ, Brazil

1990-1991 Assistant Professor Departamento de Farmacologia Básica e Clínica (Dept. Basic and Clinical Pharmacology) Universidade Federal do Rio de Janeiro (Federal University of Rio de Janeiro) Rio de Janeiro, RJ, Brazil

1998-2003 Research Associate Department of Pharmacology and Experimental Therapeutics University of Maryland School of Medicine

2003-2010 Assistant Professor Department of Pharmacology and Experimental Therapeutics University of Maryland School of Medicine

2010-2014 Assistant Professor Department of Epidemiology and Public Health University of Maryland School of Medicine

2014-present Associate Professor Department of Epidemiology and Public Health University of Maryland School of Medicine

2018-present Director of Division Division Translational Toxicology Department of Epidemiology and Public Health University of Maryland School of Medicine

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Pereira, Edna F.R. Other Employment

1986-1989 Pharmacy Doctor Secretaria Municipal de Saúde do Rio de Janeiro Hospital Municipal Paulino Werneck Instituto Municipal da Mulher Fernando Magalhães Rio de Janeiro, RJ, Brazil

Professional Society Memberships

1989- Sociedade Brasileira de Farmacologia e Terapêutica Experimental (Brazilian Society of Pharmacology and Experimental Therapeutics) 1990- Society for Neuroscience 1996- American Association for the Advancement of Science 2008- American Society of Pharmacology and Experimental Therapeutics

Honors and Awards

1989-1990 Fellowships from Conselho Nacional de Pesquisa e Desenvolvimento and Coordenação de Aperfeiçomaento de Pessoal de Nível Superior (Brazil) for training in Molecular Pharmacology

2007-present Member of the International Who’s Who of Professionals

Institutional Service

2005 Curriculum Committee (member) Creation of the Pharmacology Track of the Molecular Medicine Graduate Program Department of Pharmacology and Experimental Therapeutics University of Maryland School of Medicine

2006 MS Admission’s Committee (member) Master Program in Pharmacology Pharmacology Track of the Molecular Medicine Graduate Program Graduate Program in Life Sciences University of Maryland School of Medicine

2007, 2010 Admission’s Committee (member) Molecular Medicine Graduate Program Graduate Program in Life Sciences University of Maryland School of Medicine

2010 Mock Study Section (member) Department of Epidemiology and Public Health University of Maryland School of Medicine

2011-present PIN Admission’s Committee (interviewer) Program in Neuroscience Graduate Program in Life Sciences University of Maryland School of Medicine

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Pereira, Edna F.R. 2015-2017 Admission’s Committee (member) Graduate Program in Toxicology Graduate Program in Life Sciences University of Maryland School of Medicine

2015-present Promotions Committee (member) Department of Epidemiology and Public Health University of Maryland School of Medicine

2017-2018 Admission’s Committee (member) PhD Program in Molecular Medicine Graduate Program in Life Sciences University of Maryland School of Medicine

2017-2020 SOM Faculty Council Representative Department of Epidemiology and Public Health University of Maryland School of Medicine

2017-2020 Admission’s Committee (member) Master Program in Toxicology Graduate Program in Life Sciences University of Maryland School of Medicine

2017-2020 Admission’s Committee (member) PhD Program in Molecular Medicine Graduate Program in Life Sciences University of Maryland School of Medicine

National Service

2018-present VA Study Section ZRD1 SPLD-B (01) Gulf War Review Panel 2018, 2020 NIH Study Sessions ZRG1 MDCN-B50R, ZRG1 MDCN-B54R (Adhoc member) 2019 NIH study section NAL (Adhoc member) 2019 Member of the CDMRP's Combat Readiness - Medical Research Program Stakeholders Panel 2016 Reviewer of a Toxicological Profile for the Agency for Toxic Substances and Disease Registry and the Centers for Disease Control & Prevention 2010-present Reviewer for PLOS One, Journal of Neurochemistry, Journal of Pharmacology and Experimental Therapeutics, Journal of Alzheimer's Disease, Biochemical Pharmacology, Brain Research, Journal of Neuroscience, Neuroscience Letters 2008 Local organizer XIII International Symposium on Mechanisms 2007 Peer reviewer of proposals submitted to the Philip Morris External Research Program 2004 NCI/NIH special emphasis panel ZCA1 GRB-I (Adhoc member)

International Service

2012 Peer reviewer of proposals submitted to Comitato Telethon Fondazione Onlus, Italy 4

Pereira, Edna F.R. 2008-present Member of the International Advisory Board of the International Symposium on Cholinergic Mechanisms 1990-2010 Member of the Editorial Board of Revista Brasileira de Farmácia

Teaching and Mentoring Service Medical Teaching (University of Maryland School of Medicine) 2006-2011, 2013 Role: Lecturer Course: Pathophysiology & Therapeutics, I (MSPR 521); ca. 150 students/year; 1 contact hour per year Lecture: Heavy Metal Pharmacology and Treatment

2009-2012, 2014 Role: Lecturer Course: Pathophysiology & Therapeutics, II (MSPR 522); ca. 150 students/year; 1 contact hour per year Lecture: Introduction to Neuropharmacology

2016-2020 Role: Lecturer Course: Neuroscience; ca. 150 students/year; 2 contact hours per year Lecture: Neurochemistry: Introduction and ; Aminoacid Neurotransmitters

2017 Role: Moderator Small Group Discussion Course: P&T1; ca. 150 students/year; 2 contact hours Topic: Critical Appraisal of a Scientific Article

2017 Role: Moderator Small Group Discussion Course: P&T2; ca. 150 students/year; 2 contact hours Topic: Clinical Study Evaluations

2019 Role: Moderator Small Group Discussion Course: P&T2; ca. 150 students/year; 2 contact hours Topic:

2020-present Role: Lecturer Course: ca. 150 students/year; 2 contact hours Topic: Pharmacokinetics

Graduate Teaching (University of Maryland School of Medicine) 1999-2005 Role: Lecturer Course: Pharmacological Biotechnology (MPET612); ca. 6-10 students/semester; 1.5 contact hours/semester, Spring semester Lecture: Gene Therapy (1999-2002) and Stem Cell Research (2003-2005)

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Pereira, Edna F.R. 1999-2005 Course: Integrative Pharmacology (MPET615); ca. 6-10 students/semester; 1 contact hours/semester, Spring semester Lecture: CNS Nicotinic Pharmacology

2001-2005 Role: Lecturer (2001-2005) and co-course master (2003-2005) Course: Molecular Neuropharmacology (MPET/NACS602); ca. 10-15 students/semester; 21 contact hours/semester, Fall semester Lectures: Electrophysiological Methods in Drug Receptor Research, Post- Translational Modification of Receptor Channels, Receptor Desensitization/Modeling, Miscellaneous Neuroreceptors

2007-2015 Roles: Course master (from 2007 to 2012 and 2013-2015) and lecturer (from 2007 to 2015) Course: Neuropharmacology: Basic to Clinical Approaches (GPLS604); ca. 7-15 students/semester; 4 contact hours/week, Fall semester Lectures: Glutamate pharmacology; GABA pharmacology; Cholinergic pharmacology; Pathophysiology and pharmacological treatment of Alzheimer’s disease and Myasthenia Gravis

2008-present Role: Small group moderator Course: Core Course (GPLS601); ca. 12 students/group/semester; 8 contact hours/semester, Fall semester Topics: Modeling receptor function; Kinetics of drug-receptor interactions

2008-present Role: Lecturer and Course Director Course: Molecular Toxicology (GPLS623); ca. 4-11 students/semester; 50 contact hours/semester, Fall semester Topics: Heavy metal toxicity; Drug Addiction; Organophosphorus Insecticides

2009-2020 Role: Lecturer Course: Systems Neuroscience (GPLS641); 4 contact hours/semester, Spring semester Lectures: Introduction to synaptic transmission: Acetylcholine; Fast amino acid transmitters: Glutamate and GABA

Undergraduate Student Mentoring

2005, 2006 Student: Dina Ioffe Summer Research Training Program; daily contact during the Summer (8 weeks) 2004 Students: Tiara Gary; Nadia Chaudhry Summer Research Training Program; daily contact during the Summer (8 weeks)

Graduate Student Mentoring 2000-2004 Role: Mentor PhD Trainee: Luis E.F. Almeida 6

Pereira, Edna F.R. Graduate Program in Pharmacology and Experimental Therapeutics University of Maryland School of Medicine Project: Naltrexone, an opioid antagonist, and alter function and expression of nicotinic receptors in the central nervous system: Implication for smoking cessation programs

2005-2008 Role: Mentor MSc Trainee: Iusta Caminha, MD Molecular Medicine Track, Graduate Program in Life Sciences University of Maryland School of Medicine Project: Tamoxifen modulation of α7 nicotinic receptor activity in hippocampal neurons: A possible mechanism for impairment

2010-2016 Role: Mentor PhD student: Richard D. Burke Program in Toxicology, Graduate Program in Life Sciences University of Maryland School of Medicine Project: Developmental of the organophosphorus

2011-2017 Role: Mentor PhD student: Spencer W. Todd Program in Toxicology, Graduate Program in Life Sciences University of Maryland School of Medicine Project: Epigenetic mechanisms affected in the brain by developmental exposure to the pesticide chlorpyrifos

2014-2019 Role: Co-Mentor PhD student: Eric W. Lumsden Program in Toxicology, Graduate Program in Life Sciences University of Maryland School of Medicine Project: Organophosphorus insecticides as developmental neurotoxicants: Potential mechanisms contributing to disruption of synaptic transmission and cognition

2015-2020 Role: Co-Mentor PhD student: Allison Jackovitz Program in Toxicology, Graduate Program in Life Sciences University of Maryland School of Medicine Project: Development and application of models to investigate the risk of defense-relevant chemicals

Graduate Student Thesis Committees 2002 Doctoral dissertation committee member Dana Perkins, Ph.D. in Pharmacology 2006 Master dissertation committee member Tessie Palouse, M.S. in Pharmacology

2006 Doctoral dissertation committee member Erin Golembewski, Ph.D. in Pharmacology 2006 Doctoral examination committee member 7

Pereira, Edna F.R. Jenniffer Laing, Ph.D. in Pharmacology.

2006 Doctoral dissertation committee member David Yeung, Ph.D. in Pharmacology

2008 Master’s dissertation committee chair Iusta Caminha, MD, M.S. in Pharmacology

2009 Doctoral dissertation committee member Jennifer Laing, Ph.D. in Pharmacology

2010 Doctoral dissertation committee member Sarah Clark, Ph.D. in Pharmacology

2010 Doctoral dissertation committee member Girish Kulkarni, Ph.D. in Toxicology

2012-2014 Doctoral dissertation committee member Abhishruti Parihar, Ph.D. in Toxicology

2012-2014 Doctoral advisory committee member Jacob Skovira, Ph.D. in Molecular Medicine

2011-2015 Doctoral dissertation committee member Nathaniel Safren, Ph.D. in Neuroscience

2011-2015 Doctoral dissertation committee member Kathleen Giplin, Ph.D. in Neuroscience 2012-2015 Doctoral dissertation committee member Roger J. Mullins, Ph.D. in Neuroscience

2012-2016 Doctoral dissertation committee member Mark Schultz, Ph.D. in Neuroscience

2012-2016 Doctoral dissertation committee chair Richard D. Burke, Ph.D. in Toxicology

2013-2017 Doctoral dissertation committee chair Spencer W. Todd, Ph.D. in Toxicology

2014-2019 Doctoral dissertation committee chair Eric W. Lumsden, Ph.D. in Toxicology

2014-2020 Doctoral dissertation committee chair Allison Jackovitz, Ph.D. in Toxicology

2018-2020 Doctoral dissertation committee member Jackie Highland, Ph.D. in Toxicology

2018-present Doctoral dissertation committee member Lace M. Riggs Ph.D. candidate, Program in Neuroscience

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Pereira, Edna F.R. 2019-present Doctoral dissertation committee member Tim Tropolli Ph.D. candidate, Program in Neuroscience

Post-Doctoral Fellow and Junior Faculty Mentoring 2005-2006 Role: Co-Mentor Post-doctoral trainee: Dr. Maria F.M. Braga University of Maryland School of Medicine Project: Effects of Pb2+ on spontaneous and evoked release of neurotransmitters in the central nervous system

2009-2010 Role: Co-Mentor Post-doctoral fellow: Dr. William Fawcett University of Maryland School of Medicine Project: Effects of organophosphorus compounds on activity in different tissues

2009-2010 Role: Co-Mentor Post-doctoral trainee: Dr. Yasco Aracava University of Maryland School of Medicine Project: Development of an antidotal therapy against organophosphorus poisoning 2013-2015 Role: Co-Mentor Post-doctoral trainee: Dr. Elena Alexandrova University of Maryland School of Medicine Project: Electroencephalographic activity in rodents exposed to organophosphorus compounds

2020-present Role: Junior Faculty Advisor Junior Faculty: Dr. Panos Zanos Department of Psychiatry University of Maryland School of Medicine

Grant Support

Active Grants 01/01/2018-12/31/22 5R01ES027822-04 (Role: Contact PI) NIH/NIEHS Mulit-PI: Pereira, Gullapalli “Targeting M1/M3 Muscarinic Receptors to Treat Gestational Pesticide Poisoning”

09/01/2020-08/31/2022 1R21 HD095429-01A1 (Role: Co-Investigator) NICHD/NIH PI: Mamczarz “Effect of Prenatal Exposure to Acetaminophen During Critical Period of Brain Growth Spurt on Exploratory and Cognitive Behavior: Guinea Pig Model”

Completed Grants 04/01/2016-01/31/2021 (Role: Co-Investigator) 5R01 MH107615-05 (Gould, PI)

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Pereira, Edna F.R. “Therapeutic Efficacy of Metabolites for Depression Treatment” NIH/NIMH

09/01/2018-08/31/20 2R01ES027822-01S1 (Role: Contact PI) Mulit-PI: Pereira, Gullapalli “Targeting M1/M3 Muscarinic Receptors to Treat Gestational Pesticide Poisoning” NIH/NIEHS

07/01/2010-06/30/2015 (Role: Co-Investigator) 5R01 ES019282-05 PIs: Albuquerque, Gullapalli, Mamczarz, Randall “Neurotoxicity of Organophosphorus in Developing Guinea Pigs” NIH/NIEHS

08/01/2013-11/30/2015 (Role: Site PI) HHSO100201100030C Multi-PI: Pereira, Albuquerque, DeTolla “ Countermeasure for Sub-Lethal Exposure” Countervail Corp./BARDA DHHS Contract

09/01/2010-08/31/2017 (Roles: Co-investigator; Scientific Director, GLP compliance) 5R44NS068049-05 PI: Basinger “Definitive Studies for Use of as a Pre-Treatment Countermeasure Against Nerve Agent Poisoning” NIH/NINDS 09/30/2006-05/31/2014

5U01NS059344-05 (Role: Co-investigator) PI: Albuquerque “Age and Sex Effects on Nerve Agent Damage to the Brain and Antidotal Therapies” NIH/NINDS

07/01/2004-06/30/2005 (Role: PI) “Effects of Prenatal Exposure to Nicotine on Synaptic Activity & Neuronal Structure in the CA1 Field of the Hippocampus: Involvement of α7 nicotinic receptors” Faculty Research Project under Other -Related Diseases (OTRD) Grant

07/01/1987-04/30/2014 (Role: Co-investigator 2000-2014) 5R01NS025296-23 PI: Albuquerque “Nicotinic receptors: Role in hippocampal synaptic function” NIH/NINDS

Patents, Inventions, and Copyrights International Patent Application PCT/US05/33789. Filed on September 23, 2005. Currently licensed to CounterVail Corporation Title: Galantamine as an antidote against OP poisoning Inventors: Albuquerque, Adler, Pereira

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Pereira, Edna F.R. Publications

Journal articles 1. Pereira, E.F.R., Pereira, N.A., Lima, M.E.F., Coelho, F.A.S., Barreiro, E.J. (1989) Anti-inflammatory properties of new bioisosteres of indomethacin synthesized from safrole which are sulindac analogues. Braz. J. Med. Biol. Res., 22: 1415-1420. 2. Pereira, E.F.R., Pereira, N.A. (1989) Atividade analgésica-antiinflamatória um extrato alcoólico de Boia-Caá ou Paracary (Marsypianthes hyptoides Mart.). (Analgesic and anti-inflammatory activity of an ethanolic extract of Boia-Caá or Paracary - Marsypianthes hyptoides Mart.). Rev. Bras. Farm., 70: 59-60. 3. Ruppelt, B.M., Pereira, E.F.R., Gonçalves, L.C., Pereira, N.A. (1991) Pharmacological screening of recommended by folk medicine as anti- - I. Analgesic and anti-inflamatory activities. Mem. Inst. Oswaldo Cruz, 86: 203-205. 4. Aracava, Y., Fróes-Ferrão, M.M., Pereira, E.F.R., Albuquerque, E.X. (1991) Sensitivity of N-methyl-D-aspartate (NMDA) and nicotinic acetylcholine receptors to ethanol and pyrazole. Ann. N. Y. Acad. Sci., 234: 451-472. 5. Pereira, E.F.R., Aracava, Y., Aronstam, R.S., Barreiro, E.J., Albuquerque, E.X. (1992) Pyrazole, an dehydrogenase inhibitor, has dual effects on N-methyl- D-aspartate receptors in hippocampal pyramidal cells: and non-competitive antagonist. J. Pharmacol. Exp. Ther., 261: 331-340. 6. Alkondon, M., Pereira, E.F.R., Wonnacott, S., Albuquerque, E.X. (1992) Blockade of nicotinic receptors on hippocampal neurons defines as a potent and selective competitive antagonist. Mol. Pharmacol., 41: 802-808. 7. Pereira, E.F.R., Alkondon, M., Tano, T., Castro, N.G., Fróes-Ferrão, M.M., Rozental, R., Aronstam, R.S., Schrattenholz, A., Maelicke, A., Albuquerque, E.X. (1993) A novel agonist binding site on nicotinic acetylcholine receptors. J. Receptor Res., 13: 413-436. 8. Thomas, P., Stephens, M., Wilkie, G., Amar, M., Lunt, G.G., Whiting, P., Gallager, T., Pereira, E., Alkondon, M., Albuquerque, E.X., Wonnacott, S. (1993) (+)- Anatoxin is a potent agonist at neuronal nicotinic acetylcholine receptors. J. Neurochem., 60: 2308-2311. 9. Pereira, E.F.R., Reinhardt-Maelicke, S., Schrattenholz, A., Maelicke, A., Albuquerque, E.X. (1993) Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons. J. Pharmacol. Exp. Ther., 265: 1474-1491. 10. Schrattenholz, A., Coban, T., Schroder, B., Okonjo, O.K., Kuhlmann, J., Pereira, E.F.R., Albuquerque, E.X., Maelicke, A. (1993) Biochemical characterization of a novel channel-activating site on nicotinic acetylcholine receptors. J. Receptor Res., 13: 393-412. 11. Maelicke, A., Coban, T., Schrattenholz, A., Schröder, S., Reinhardt-Maelicke, S., Godovac-Zimmermann, J., Methfessel, C., Pereira, E.F.R., Albuquerque, E.X. (1993) and neuromuscular transmission. Ann. N.Y. Acad. Sci., 681: 140-154. 12. Pereira, E.F.R., Alkondon, M., Reinhardt-Maelicke, S., Maelicke, A., Peng, X., Lindstrom, J., Whiting, P., Albuquerque, E.X. (1994) Physostigmine and galanthamine characterize the presence of the novel binding site on the α4β2 subtype of neuronal nicotinic acetylcholine receptors stably expressed in fibroblast cells. J. Pharmacol. Exp. Ther., 270: 768-778. 13. Albuquerque, E.X., Pereira, E.F.R., Castro, N.G., Alkondon, M., Reinhardt, S., Schroder, H., Maelicke, A. (1995) Nicotinic receptor function in the mammalian central nervous system. Ann. N.Y. Acad. Sci., 757: 48-72. 14. Maelicke, A., Schrattenholz, A., Storch, A., Schroder, B., Gutbrod, O., Methfessel, C., Weber, K.-H., Pereira, E.F.R., Alkondon, M., Albuquerque, E.X. (1995) 11

Pereira, Edna F.R. Noncompetitive agonism at nicotinic acetylcholine receptors: Functional significance for CNS signal transduction. J. Receptor Signal Transduc. Res., 15: 333-353. 15. Albuquerque, E.X., Pereira, E.F.R., Castro, N.G., Alkondon, M. (1995) Neuronal nicotinic receptors: Function, modulation, and structure. Sem. Neurosci., 7: 91- 101. 16. Grando, S.A., Horton, R.M., Pereira, E.F.R., Diethelm-Okita, B.M., George, P.M., Albuquerque, E.X., Conti-Fine, B.M. (1995) A nicotinic regulating cell adhesion and motility is expressed in human keratinocytes. J. Invest. Dermatol., 105: 774-781. 17. Storch, A., Schrattenholz, A., Cooper, J.C., Ghani, E.M.A., Gutbrod, O., Weber, K.- H., Reinhardt, S., Lobron, C., Hermsen, B. Soskic, V., Pereira, E.F.R., Albuquerque, E.X., Methfessel, C., Maelicke, A. (1995) Physostigmine, galanthamine and codeine act as non-competitive on clonal rat pheocromocytoma cells. Eur. J. Pharmacol., 290: 207-219. 18. Maelicke, A., Schrattenholz, A., Storch, A., Schroder, B., Gutbrod, O., Methfessel, C., Weber, K.H., Pereira, E.F.R., Alkondon, M., Albuquerque, E.X. (1995) Noncompetitive agonism at nicotinic acetylcholine receptors: Functional significance for CNS signal transduction. J. Receptor & Signal Transduction Res., 15: 333-353. 19. Schrattenholz, A., Pereira, E.F.R., Methfessel, C., Roth, U., Weber, K.-H., Albuquerque, E.X., Maelicke, A. (1996) Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting ligands. Mol. Pharmacol., 49: 1-6. 20. Pereira, E.F.R., Alkondon, M, McIntosh, J.M., Albuquerque, E.X. (1996) α- -ImI, a competitive at α--sensitive neuronal nicotinic receptors. J. Pharmacol. Exp. Ther., 278: 1472-1483. 21. Alkondon, M., Pereira, E.F.R., Albuquerque, E.X. (1996) Mapping the location of functional nicotinic and γ-aminobutyric acidA receptors on hippocampal neurons. J. Pharmacol. Exp. Ther., 279: 1491-1506. 22. Albuquerque, E.X., Pereira, E.F.R., Bonfante-Cabarcas, R., Marchioro, M., Matsubayashi, H., Alkondon, M., Maelicke, A. (1996) Nicotinic acetylcholine receptors on hippocampal neurons: Cell compartment-specific expression and modulatory control of channel activity. Prog. Brain Res., 109: 111-124. 23. Albuquerque, E.X., Pereira, E.F.R., Alkondon, M., Schrattenholz, A., Maelicke, A. (1997) Nicotinic acetylcholine receptors on hippocampal neurons: Distribution on the neuronal surface and modulation of receptor activity. J. Receptor & Signal Transduction Res., 17: 243-266. 24. Maelicke, A., Coban, T., Storch, A., Schrattenholz, A., Pereira, E.F.R., Albuquerque, E.X. (1997) Allosteric modulation of torpedo nicotinic acetylcholine receptor ion channel activity by noncompetitive agonists. J. Receptor & Signal Transduction Research, 17: 11-28. 25. Alkondon, M., Pereira, E.F.R., Cortes, W.S., Maelicke, A., Albuquerque, E.X. (1997) is a natural agonist of α7 nicotinic acetylcholine receptors. Eur. J. Neurosci., 9: 101-109.

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Pereira, Edna F.R. 26. Alkondon, M., Pereira, E.F.R., Barbosa, C.T.F., Albuquerque, E.X. (1997) Neuronal nicotinic acetylcholine receptor activation modulates γ-amino butyric acid release from CA1 neurons of rat hippocampal slices. J. Pharmacol. Exp. Ther., 283: 1396- 1411. 27. Matsubayashi, H., Alkondon, M., Pereira, E.F.R., Swanson, K.L., Albuquerque, E.X. (1998) : A potent competitive antagonist of α-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal neurons. J. Pharmacol. Exp. Ther., 284: 904-913. 28. Macklin, Kevin D., Maus, A.D.J., Pereira, E.F.R., Albuquerque, E.X., Conti-Fine, B.M. (1998) Human vascular endothelial cells express functional nicotinic acetylcholine receptors. J. Pharmacol. Exp. Ther., 287: 435-439. 29. Alkondon, M., Pereira, E.F.R., Albuquerque, E.X. (1998) α-Bungarotoxin- and methyllycaconitine-sensitive nicotinic receptors mediate fast synaptic transmission in interneurons of rat hippocampal slices. Brain Res., 810: 257-263. 30. Maus, A.D.J., Pereira, E.F.R., Karachunski, P.I., Horton, R.M., Navaneetham, D., Macklin, K., Cortes, W.S., Albuquerque, E.X., Conti-Fine, B.M. (1998) Human and rodent bronchial epithelial cells express functional nicotinic receptors. Mol. Pharmacol., 54: 779-788. 31. Albuquerque, E.X., Pereira, E.F.R., Braga, M.F.M., Alkondon, M. (1998) Contribution of nicotinic receptors to the function of synapses in the central nervous system: The action of choline as a selective agonist of α7 receptors. J. Physiol. (Paris), 92: 309-316. 32. Albuquerque, E.X., Pereira, E.F.R., Braga, M.F.M., Matsubayashi, H., Alkondon, M. (1998) Neuronal nicotinic receptors modulate synaptic function in the hippocampus and are sensitive to blockade by the convulsant strychnine and by the anti-Parkinson drug . Toxicol. Lett., 102-103: 211-218. 33. Braga, M.F.M., Pereira, E.F.R., Albuquerque, E.X. (1999) Nanomolar concentrations of lead inhibit glutamatergic and gabaergic transmission in hippocampal neurons. Brain Res., 826: 22-34. 34. Braga, M.F.M., Pereira, E.F.R., Marchioro, M., Albuquerque, E.X. (1999) Lead increases -insensitive spontaneous release of glutamate and GABA from hippocampal neurons. Brain Res., 826: 10-21. 35. Alkondon, M., Pereira, E.F.R., Eisenberg, H.M., Albuquerque, E.X. (1999) Choline and selective antagonists identify two subtypes of nicotinic acetylcholine receptors that modulate GABA release from CA1 interneurons in rat hippocampal slices. J. Neurosci., 19: 2693-2705. 36. Wevers, A., Monteggia, L., Nowacki, S., Bloch, W., Schütz, U., Lindstrom, J., Pereira, E.F.R., Eisenberg, H.M., Giacobini, E., deVos, R.A.I, Jansen Steur, E.N.H., Maelicke, A., Albuquerque, E.X., Schröder, H. (1999) Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer’s disease -- Histotopographical correlation with amyloid plaques and hyperphosphorylated tau-protein. Eur. J. Neurosci., 11: 2551-2565. 37. Alkondon, M., Pereira, E.F.R., Eisenberg, H.M., Albuquerque, E.X. (2000) Nicotinic receptor activity in human cerebral cortical interneurons: A mechanism for inhibition and disinhibition of neuronal networks. J. Neurosci., 20: 66-72. 38. Albuquerque, E.X., Pereira, E.F.R., Mike, A., Eisenberg, H.M., Maelicke, A., Alkondon, M. (2000) Neuronal nicotinic receptors in synaptic functions in humans and rats: Physiological and clinical relevance. Behav. Brain Res., 113: 131-141. 39. Alkondon, M., Braga, M.F.M., Pereira, E.F.R., Maelicke, A., Albuquerque, E.X. (2000) α7 Nicotinic acetylcholine receptors and modulation of GABAergic synaptic transmission in the hippocampus. Eur. J. Pharmacol., 393: 59-67. 40. Mike, A., Pereira, E.F.R., Albuquerque, E.X. (2000) Ca2+-sensitive inhibition by

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Pereira, Edna F.R. Pb2+ of α7-containing nicotinic acetylcholine receptors in hippocampal neurons. Brain Res., 873: 112-123. 41. Alkondon, M., Pereira, E.F.R., Almeida, L.E.F., Randall, W.R., Albuquerque, E.X. (2000) Nicotine at concentrations found in cigarette smokers activates and desensitizes nicotinic acetylcholine receptors in CA1 interneurons of rat hippocampus. Neuropharmacology, 39: 2726-2739. 42. Almeida, L.E.F., Pereira, E.F.R., Alkondon, M., Fawcett, W.P., Randall, W.R., Albuquerque, E.X. (2000) The opioid antagonist naltrexone inhibits activity and alters expression of α7 and α4β2 nicotinic receptors: Implications for smoking cessation programs. Neuropharmacology, 39: 2740-2755. 43. Wang, Y., Pereira, E.F.R., Maus, A.D., Ostlie, N.S., Navaneetham, D., Lei, S., Albuquerque, E.X., Conti-Fine, B.M. (2001) Human bronchial epithelial and endothelial cells express α7 nicotinic acetylcholine receptors. Mol. Pharmacol., 60: 1201-1209. 44. Albuquerque, E.X., Santos, M.D., Alkondon, M., Pereira, E.F.R., Maelicke, A. (2001) Modulation of nicotinic receptor activity in the central nervous system – A novel approach to the treatment of Alzheimer’s disease. Alzheimer Dis. Assoc. Disord., 15: S19-25. 45. Peçanha, E.P., Fraga, C.A.M., Barreiro, E.J., Braga, M.R.M., Pereira, E.F.R., Albuquerque, E.X. (2001) Synthesis and pharmacological evaluation of a new 2- azabicyclo[3.3.0]octane derivative. J. Braz. Chem. Soc., 12: 408-412. 46. Hilmas, C., Pereira, E.F.R., Alkondon, M., Rassoulpour, A, Schwarcz, R., Albuquerque, E.X. (2001) The brain metabolite hynurenic acid inhibits α7 nicotinic receptor activity and increases non-α7 nicotinic receptor expression: Physiopathological implications. J. Neurosci., 21: 7463-7473. 47. Perkins, D., Pereira, E.F.R., Aurelian, L. (2001) A herpes simplex virus type 2 protein (ICP10 PK) inhibits caspase-3 activation in hippocampal neurons. Cell Notes, 2: 7-8. 48. Gonzalez-Serratos, H., Chang, R., Pereira, E.F.R., Castro, N.G., Aracava, Y., Melo, P.A., Lima, P.C., Fraga, C.A.M., Barreiro, E.J., Albuquerque, E.X. (2001) A novel thienylhydrazone, (2-thienylidene)3,4-methylenedioxybenzoylhydrazine, increases inotropism and decreases fatigue of skeletal muscle. J. Pharmacol. Exp. Ther., 299: 558-566. 49. Perkins, D., Pereira, E.F.R., Gober, M., Yarowski, P.J., Aurelian, L. (2002) The herpes simplex virus type 2 R1 PK (ICP10 PK) blocks apoptosis in hippocampal neurons involving activation of the MEK/MAPK survival pathway. J. Virol., 76: 1435-1449. 50. Pereira, E.F.R., Hilmas, C., Santos, M.D., Alkondon, M., Maelicke, A., Albuquerque, E.X. (2002) Unconventional ligands and modulators of nicotinic receptors. J. Neurobiol., 53: 479-500. 51. Santos, M.D., Alkondon, M., Pereira, E.F.R., Aracava, Y., Eisenberg, H.M., Maelicke, A., Albuquerque, E.X. (2002) The nicotinic allosteric potentiating galantamine facilitates synaptic transmission in the mammalian central nervous system. Mol. Pharmacol., 61: 1222-1234. 52. Alkondon, M., Pereira, E.F.R., Albuquerque, E.X. (2003) NMDA and AMPA receptors contribute to the nicotinic cholinergic excitation of CA1 interneurons in the rat hippocampus. J. Neurophysiol., 90: 1613-1625. 53. Perkins, D., Gyure, K.A., Pereira, E.F.R., Aurelian, L. (2003) Herpes simplex virus type 1-induced encephalitis has an apoptotic component associated with activation of c-Jun N-terminal kinase. J. Neurovirol., 9: 101-111. 54. Perkins, D., Pereira, E.F.R., Aurelian, L. (2003) The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) functions as a dominant regulator of apoptosis in

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Pereira, Edna F.R. hippocampal neurons involving activation of the ERK survival pathway and upregulation of the antiapoptotic protein Bag-1. J. Virol., 77: 1292-1305. 55. Almeida, L.E.F., Pereira, E.F.R. †, Camara, A.L., Maelicke, A., Albuquerque, E.X. (2004) Sensitivity of neuronal nicotinic acetylcholine receptors to the opiate antagonists naltrexone and naloxone: receptor blockade and up-regulation. Bioorg. Med. Chem. Lett., 14: 1879-1887. 56. Alkondon, M., Pereira, E.F.R., Yu, P., Arruda, E.Z., Almeida, L.E.F., Guidetti, P., Fawcett, W.P., Sapko, M.T., Randall, W.R., Schwarcz, R., Tagle, D.A., Albuquerque E.X. (2004) Targeted deletion of the kynurenine aminotransferase II gene reveals a critical role of endogenous in the regulation of synaptic transmission via α7 nicotinic receptors in the hippocampus. J. Neurosci., 24: 4635-4648. 57. Braga, M.F.M., Pereira, E.F.R., Mike, A., Albuquerque, E.X. (2004) Pb2+ via protein kinase C inhibits nicotinic cholinergic modulation of synaptic transmission in the hippocampus. J. Pharmacol. Exp. Ther., 311: 700-710. 58. Aracava, Y., Pereira, E.F.R. , Maelicke, A., Albuquerque, E.X. (2005) blocks a7* nicotinic acetylcholine receptors more potently than N-methyl-D- aspartate receptors in rat hippocampal neurons. J. Pharmacol. Exp. Ther., 312: 1195-1205. 59. Albuquerque, E.X., Pereira, E.F.R., Aracava, Y., Fawcett, W.P., Oliveira, M., Randall, W.R., Hamilton, T.A., Kan, R.K., Romano Jr., J.A., Adler, M. (2006) An effective countermeasure against poisoning by organophosphorus insecticides and nerve agents. Proc. Natl. Acad. Sci. U.S.A., 103: 13220-13225. 60. Popa, R.V., Pereira, E.F.R., Lopes, C., Maelicke, A., Albuquerque, E.X. (2006) The N-butylcarbamate derivative of galantamine acts as an allosteric potentiating ligand on a7 nicotinic receptors in hippocampal neurons: clinical implications for treatment of Alzheimer's disease. J. Mol. Neurosci., 30: 227-232. 61. Lopes, C., Pereira, E.F.R., Wu, H.Q., Purushottamachar, P., Njar, V., Schwarcz, R., Albuquerque, E.X. (2007) Competitive Antagonism between the nicotinic allosteric potentiating ligand galantamine and kynurenic acid at a7* nicotinic receptors. J. Pharmacol. Exp. Ther., 322: 48-58. 62. Alkondon, M., Pereira, E.F.R., Potter, M.C., Kauffman, F.C., Schwarcz, R., Albuquerque, E.X. (2007) Strain-specific nicotinic modulation of glutamatergic transmission in the CA1 field of the rat hippocampus: August Copenhagen Irish versus Sprague-Dawley. J. Neurophysiol., 97: 1163-1170. 63. Alkondon, M., Pereira, E.F.R., Albuquerque, E.X. (2007) Age-dependent changes in the functional expression of two nicotinic receptor subtypes in CA1 stratum radiatum interneurons in the rat hippocampus. Biochem. Pharmacol., 74: 1134- 1144. 64. Alkondon, M., Aracava, Y., Pereira, E.F.R., Albuquerque, E.X. (2009) A single in vivo application of cholinesterase inhibitors has neuron type-specific effects on nicotinic receptor activity in guinea pig hippocampus. J. Pharmacol. Exp. Ther., 328: 69-82. 65. Fawcett, W.P., Aracava, Y., Pereira, E.F.R., Albuquerque, E.X. (2009) Acute toxicity of organophosphorus compounds in guinea pigs is sex and age dependent and cannot be solely accounted for by inhibition. J. Pharmacol. Exp. Ther., 328: 516-524. 66. Albuquerque, E.X., Pereira, E.F.R., Alkondon, M., Rogers, S.W. (2009) Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol. Rev., 89: 73-120. 67. Aracava, Y., Pereira, E.F.R., Akkerman, M., Adler, M., Albuquerque, E.X. (2009)

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Pereira, Edna F.R. Effectiveness of , , and ± in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine. J. Pharmacol. Exp. Ther., 331: 1014-1024. 68. Gullapalli, R.P., Aracava, Y., Zhuo, J., Neto, E.H., Wang, J., Makris, G., Merchenthaler, I., Pereira, E.F.R., Albuquerque, E.X. (2010) Magnetic resonance imaging reveals that galantamine prevents structural brain damage induced by an acute exposure of guinea pigs to . Neurotoxicology, 31: 67-76. 69. Mamczarz, J., Pereira, E.F.R., Aracava, Y., Adler, M., Albuquerque, E.X. (2010) An acute exposure to a sub-lethal dose of soman triggers -related behavior in guinea pigs: Interactions with acute restraint. Neurotoxicology, 31: 77-84. 70. Pereira, E.F.R., Aracava, Y., Alkondon, M., Akkerman, M., Merchenthaler, I., Albuquerque, E.X. (2010) Molecular and cellular actions of galantamine: clinical implications for treatment of organophosphorus poisoning. J. Mol. Neurosci., 40: 196-203. 71. Wu, H.Q., Pereira, E.F.R., Bruno, J.P., Pellicciari, R., Albuquerque, E.X., Schwarcz, R. (2010) The astrocyte-derived alpha7 nicotinic kynurenic acid controls extracellular glutamate levels in the prefrontal cortex. J. Mol. Neurosci., 40: 204-210. 72. Alexandrova, E.A., Aracava, Y., Pereira, E.F.R., Albuquerque, E.X. (2010) Pretreatment of guinea pigs with galantamine prevents immediate and delayed effects of soman on inhibitory synaptic transmission in the hippocampus. J. Pharmacol. Exp. Ther., 334: 1051-1058. 73. Alkondon, M., Pereira, E.F.R., Eisenberg, H.M., Kajii, Y., Schwarcz, R., Albuquerque, E.X. (2011) Age dependency of inhibition of α7 nicotinic receptors and tonically active NMDA receptors by endogenously produced kynurenic acid in the brain. J. Pharmacol. Exp. Ther., 337: 572-582. 74. Mamczarz, J., Kulkarni, G.S., Pereira, E.F.R., Albuquerque, E.X (2011) Galantamine counteracts development of learning impairment in guinea pigs exposed to the organophosphorus poison soman: Clinical significance. Neurotoxicology, 32: 785-798. 75. Alkondon, M, Pereira, E.F.R., Albuquerque, E.X. (2011) Endogenous activation of nAChRs and NMDA receptors contributes to the excitability of CA1 stratum radiatum interneurons in rat hippocampal slices: effects of kynurenic acid. Biochem. Pharmacol., 82: 842-851. 76. Banerjee, J., Alkondon, M., Pereira, E.F.R., Albuquerque, E.X. (2012) Regulation of GABAergic inputs to CA1 pyramidal neurons by nicotinic receptors and kynurenic acid. J. Pharmacol. Exp. Ther., 341: 500-509. 77. Mullins, R.J., Xu, S., Pereira, E.F.R., Mamczarz, J., Albuquerque, E.X., Gullapalli, R.P. (2013) Delayed hippocampal effects from a single exposure of prepubertal guinea pigs to sub-lethal dose of chlorpyrifos: A magnetic resonance imaging and spectroscopy study. Neurotoxicology, 36: 42-48. 78. Alkondon, M., Albuquerque, E.X., Pereira, E.F.R. (2013) Acetylcholinesterase inhibition reveals endogenous nicotinic modulation of glutamate inputs to CA1 stratum radiatum interneurons in hippocampal slices. Neurotoxicology, 36: 72-81. 79. Banerjee, J., Alkondon, M., Albuquerque, E.X., Pereira, E.F.R. (2013) Contribution of CA3 and CA1 pyramidal neurons to the tonic α7 nAChR-dependent glutamatergic input to CA1 pyramidal neurons. Neurosci. Lett., 554: 167-171. 80. Pereira, E.F.R., Aracava, Y., DeTolla, L.J. Jr, Beecham, E.J., Basinger, G.W. Jr, Wakayama, E.J., Albuquerque, E.X. (2014) Animal models that best reproduce the clinical manifestations of human intoxication with organophosphorus compounds. J Pharmacol Exp Ther 350: 313-321.

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Pereira, Edna F.R. 81. Alexandrova, E.A., Alkondon, M., Aracava, Y., Pereira, E.F.R., Albuquerque, E.X. (2014) Galantamine prevents long-lasting suppression of excitatory synaptic transmission in CA1 pyramidal neurons of soman-challenged guinea pigs. Neurotoxicology 44: 270-278. 82. Alkondon, M., Pereira, E.F.R., Todd, S.W., Randall, W.R., Lane, M.V., Albuquerque, E.X. (2014) Functional G-protein-coupled receptor 35 is expressed by neurons in the CA1 field of the hippocampus. Biochem Pharmacol 93:506-518. 83. Mullins, R.J., Xu, S., Pereira, E.F.R., Pescrille, J.D., Todd, S.W., Mamczarz, J., Albuquerque, E.X., Gullapalli, R.P. (2015). Prenatal exposure of guinea pigs to the organophosphorus pesticide chlorpyrifos disrupts the structural and functional integrity of the brain. Neurotoxicology 48: 9-20. 84. Mamczarz, J., Pescrille, J.D., Gavrushenko, L., Burke, R.D., Fawcett, W.P., DeTolla, Jr. L.J., Chen, H., Pereira, E.F.R., Albuquerque, E.X. (2016) Spatial learning impairment in prepubertal guinea pigs prenatally exposed to the organophosphorus pesticide phlorpyrifos: Toxicological implications. Neurotoxicology 56: 17-28. 85. Burke, R.D., Todd, S.W., Lumsden, E., Mullins, R.J., Mamczarz, J., Fawcett, W.P., Gullapalli, R.P., Randall, W.R., Pereira, E.F.R., Albuquerque, E.X. Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: From clinical findings to preclinical models and potential mechanisms. J Neurochem 142:162- 177, 2017. 86. Zanos, P., Moaddel, R., Morris, P.J., Riggs, L.M., Highland, J.N., Georgiou, P., Pereira, E.F.R., Albuquerque, E.X., Thomas, C.J., Zarate, C.A., Gould, T.D. (2018) Ketamine and ketamine metabolite pharmacology: Insights into therapeutic mechanisms. Pharmacol Rev 70: 621-660. 87. Lumsden, E.W., Troppoli, T.A., Myers, S.J., Zanos, P., Aracava, Y., Kehr, J., Lovett, J., Kim, S., Wang, F.H., Schmidt, S., Jenne, C.E., Yuan, P., Morris, P.J., Thomas, C.J., Zarate, C.A. Jr, Moaddel, R., Traynelis, S.F., Pereira, E.F.R., Thompson, S.M., Albuquerque, E.X., Gould, T.D. (2019) Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)- do not block NMDA receptor function. Proc Natl Acad Sci USA 116: 5160-5169. 88. Riggs, L.M., Aracava, Y., Zanos, P., Fischell, J., Albuquerque, E.X., Pereira, E.F.R., Thompson, S.M., Gould, T.D. (2020) (2R,6R)-hydroxynorketamine rapidly potentiates hippocampal glutamatergic transmission through a synapse-specific presynaptic mechanism. Neuropsychopharmacology 45: 426-436. 89. Hahn, B., Shrieves, M.E., Olmstead, C.K., Yuille, M.B., Chiappelli, J.J., Pereira, E.F.R., Albuquerque, E.X., Fawcett, W.P. (2020) Evidence for positive allosteric modulation of cognitive-enhancing effects of nicotine in healthy human subjects. Psychopharmacology (Berl) 237: 219-230. 90. Mullins, R.J., Xu, S., Zhuo, J., Roys, S., Pereira, E.F.R., Albuquerque, E.X., Gullapalli, R.P. (2020) Postnatal guinea pig brain development, as revealed by magnetic resonance and diffusion kurtosis imaging. Brain Sci 10: 365. 91. Lumsden, E.W., McCowan, L., Pescrille, J.D., Fawcett, W.P., Chen, H., Albuquerque, E.X., Mamczarz, J., Pereira, E.F.R. (2020) Learning and memory retention deficits in prepubertal guinea pigs prenatally exposed to low levels of the organophosphorus insecticide . Neurotoxicol Teratol 81:106914. 92. Lane, M., Carter, D., Pescrille, J.D., Aracava, Y., Fawcett, W.P., Basinger, G.W., Pereira, E.F.R., Albuquerque, E.X. (2020) Oral pretreatment with galantamine effectively mitigates the acute toxicity of a supralethal dose of soman in Cynomolgus monkeys posttreated with conventional antidotes. J Pharmacol Exp Ther 375: 115-126. 93. Hahn, B., Reneski, C.H., Lane, M., Elmer, G.I., Pereira, E.F.R. (2020) 17

Pereira, Edna F.R. Evidence for positive allosteric modulation of cognitive-enhancing effects of nicotine by low-dose galantamine in rats. Pharmacol Biochem Behav 199: 173043. 94. Todd, S.W., Lumsden, E.W., Aracava, Y., Mamczarz, J., Albuquerque, E.X., Pereira, E.F.R. (2020) Gestational exposures to organophosphorus insecticides: From acute poisoning to developmental neurotoxicity. Neuropharmacology 180: 108271. 95. Highland, J., Zanos, P., Riggs, L.M., Georgiou, P., Clark, S.M., Morris, P., Moaddel, R., Thomas, C., Zarate, C., Pereira, E.F.R., Gould, T. (2021) Hydroxynorketamines: pharmacology and potential therapeutic applications. Pharmacol Rev, in press.

Book Chapters

1. Montes, J.G., Alkondon, M., Pereira, E.F.R., and Albuquerque, E.X. (1994) The nicotinic acetylcholine receptor of mammalian central nervous system. In: Handbook of Membrane Channels: Molecular and Cell Physiology, Peracchia, C., ed., Academic Press, San Diego. 2. Montes, J.G., Alkondon, M., Pereira, E.F.R., Castro, N.G., and Albuquerque, E.X. (1994) Electrophysiological methods for the study of neuronal acetylcholine receptor ion channels. In: Ion Channels of Excitable Cells, Narahashi, T., ed., Academic Press, San Diego, Methods in Neuroscience, Vol. 19, 121-147. 3. Swanson, K.L., Alkondon, M., Pereira, E.F.R., and Albuquerque, E.X. (1995) The search for subtype-selective nicotinic acetylcholine receptor agonists. In: Chemistry and Toxicology of , ed. M. Blum, pp. 191-280. 4. Pereira, E.F.R., Alkondon, M., Albuquerque, E.X., and Maelicke, A. (1998) “Functional diversity of nicotinic acetylcholine receptors in the mammalian central nervous system: Physiological relevance.” in: Neuronal Nicotinic Receptors: Pharmacology and Therapeutic Opportunities, Eds. Stephen P. Arneric and Jorge D. Brioni, John Wiley and Sons, Inc., pp. 161-186.

Abstracts National 1. Pereira, E.F.R., Aracava, Y., Albuquerque, E.X (1990) Pyrazole activates N- methyl-d-aspartate (NMDA)-like currents. Abstr. Soc. Neurosci. 16: 86. 2. Pereira, E.F.R., Wonnacott, S., Albuquerque, E.X. (1991) Methyllycaconitine (MLA) is a potent antagonist of nicotinic acetylcholine receptors (AChR) on rat hippocampal neurons. Abstr. Soc. Neurosci. 17: 960. 3. Albuquerque, E.X., Maelicke, A., Pereira, E.F.R. (1991) Single channel currents activated by physostigmine (Phy) in hippocampal neurons are blocked by benzoquinonium (BZQ) but not by methyllycaconitine (MLA). Abstr. Soc. Neurosci. 17: 585. 4. Alkondon, M., Pereira, E.F.R., Albuquerque, E.X. (1992) Methyllycaconitine (MLA), a potent , on BGT-sensitive neuronal nicotinic acetylcholine receptors. IV Pan American Symposium on Animal, and Microbial . 5. Nelson, M., Pereira, E.F.R., Albuquerque, E.X. (1992) The sensitivity of the N- methyl-D-aspartate receptor to 9-aminoacridine compounds. Abstr. Soc. Neurosci. 18: 1510. 6. Tano, T., Pereira, E.F.R., Maelicke, A., Albuquerque, E.X. (1992) Definition of a novel agonist binding site on nicotinic acetylcholine receptors (nAChRs). Abstr. Neurosci. Soc. 18: 801. 7. Pereira, E.F.R., Lindstrom, J., Whiting, P., Maelicke, A., Reinhardt-Maleicke, S., Albuquerque, E.X. (1993) Physostigmine (PHY) activates α4β2 neuronal nicotinic 18

Pereira, Edna F.R. acetylcholine receptors (nAChRs) via a novel agonist site. Abstr. Soc. Neurosci. 19: 1537. 8. Pereira, E.F.R., Albuquerque, E.X., George, P.G., Horton, R.M., Conti-Tronconi, B.M. Grando, S.A. (1994) Neuronal nicotinic receptors (nAChRs) expressed in keratinocytes control cell adhesion and motility and are targeted by pemphigus antibodies. Abstr. Soc. Neurosci. 20: 1140. 9. Randall, W.R., Pereira, E.F.R., Gregerson, K.A., Storch, A., Maelicke, A., Albuquerque, E.X. (1994) Characteristics of nicotinic whole-cell currents in PC12 cells. Abstr. Soc. Neurosci. 20: 1139. 10. Albuquerque, E.X., Maelicke, A., Castro, N.G., Pereira, E.F.R., Yu, Y.-P., Ishihara, K. (1994) Function and modulation of hippocampal nicotinic acetylcholine receptors. Trans. Amer. Soc. Neurochem. 323: 1994. 11. Pereira, E.F.R., Albuquerque, E.X. (1994) Nicotinic responses in cultured pheocromocytoma (PC12) cells. Proceedings of the Third International Symposium “The Cholinergic Synapse: Structure, Function and Regulation”, Baltimore, MD, p. 8.5. 12. Pereira, E.F.R., Alkondon, M., McIntosh, M.M., (1995) Albuquerque, E.X. α- Conotoxin-ImI: A potent antagonist at the α-bungarotoxin (α-BGT)-sensitive hippocampal nicotinic receptor (nAChR). Abstr. Soc. Neurosci. 21: 1834. 13. Albuquerque, E.X., Pereira, E.F.R., Schrattenholz, A., Maelicke, A. (1995) Galanthamine is a positive modulator of the α-bungarotoxin-sensitive hippocampal nicotinic receptor activity. Abstr. Soc. Neurosci. 21: 1833. 14. Alkondon, M., Pereira, E.F.R., Albuquerque, E.X. (1995) Mapping the location of functional nicotinic acetylcholine receptors (nAChRs) on hippocampal neurons. Abstr. Soc. Neurosci. 21: 1581. 15. Albuquerque, E.X., Pereira, E.F.R., Creveling, C.R., Alkondon, M. (1996) Differential distribution of nicotinic acetylcholine receptor subtypes in rat hippocampal neurons. Abstr. Soc. Neurosci. 22: 1267. 16. Alkondon, M., Pereira, E.F.R., Albuquerque, E.X. (1996) Characterization of nicotinic acetylcholine receptors in CA1 neurons of rat hippocampal slices. Abstr. Soc. Neurosci. 22: 1267. 17. Pereira, E.F.R., Schrattenholz, A., Maelicke, A., and Albuquerque, E.X. (1996) Modulation of nicotinic receptor function by compounds that act through the physostigmine-binding site. Abstr. Soc. Neurosci. 22: 1268. 18. Pereira, E.F.R., Barbosa, C.T.F., Rocha, E.S., Alkondon, M., Albuquerque, E.X., Eisenberg, H.M. (1997) Neurons isolated from human neocortex express functional ligand-gated channels. 65th Annual Meeting of the Amer. Assoc. Neurol. Surgeons Poster Program, p. 132. 19. Maelicke, A., Pereira, E.F.R., Cortes, W.S., Alkondon, M., Albuquerque, E.X. (1997) Choline: A full agonist of α-bungarotoxin-sensitive nicotinic acetylcholine receptors in the central nervous system. Abstr. Soc. Neurosci. 23: 666. 20. Almeida, L.E.F., Pereira, E.F.R., Albuquerque, E.X. (1997) Naltrexone, an opioid antagonist, inhibits nicotinic receptor activity in hippocampal neurons. Abstr. Soc. Neurosci. 23: 915. 21. Pereira, E.F.R., Barbosa, C.T.F., Alkondon, M., Rocha, E.S., Albuquerque, E.X., Eisenberg, H.M. Ligand-gated ion channels on human neurons. Abstr. Soc. Neurosci. 23: 374. 22. Swanson, K.L., Rocha, E.S., Pereira, E.F.R., Albuquerque, E.X. (1997) actions on ligand-gated ion channels in the central nervous system (CNS): Toxicological relevance. Abstr. Soc. Neurosci. 23: 651. 23. Rocha, E.S., Alkondon, M., Pereira, E.F.R., Albuquerque, E.X. (1998) Choline, a by-product of acetylcholine hydrolysis, is a selective agonist of α7 nicotinic receptors: Relevance for the understanding of the mechanisms underlying the effects of cholinesterase inhibitors on the brain. U.S. Army Med. Res. Materiel 19

Pereira, Edna F.R. Command, Bioscience Review Proceedings, p. 203-204. 24. Braga, M.F.M., Pereira, E.F.R., Albuquerque, E.X. (1998) α7 and α4β2 nicotinic receptors (nAChRs) modulate evoked and spontaneous release of GABA from hippocampal neurons. Abstr. Soc. Neurosci. 24: 1585. 25. Albuquerque, E.X., Pereira, E.F.R., Braga, M.F.M. (1998) A basal α4β2 nicotinic receptor (nAChR) activity controls the release of GABA from hippocampal neurons. Abstr. Soc. Neurosci. 24: 1581. 26. Pereira, E.F.R., Braga, M.F.M., Albuquerque,.E.X. (1998) Lead (Pb2+) blocks modulation of GABA release by nicotinic receptors in hippocampal neurons in culture. Abstr. Soc. Neurosci. 24: 1584. 27. Alkondon, M., Pereira, E.F.R., Albuquerque,.E.X. (1998) Distinct nicotinic receptors (nAChRs) modulate GABA release from CA1 interneurons in rat hippocampal slices. Abstr. Soc. Neurosci. 24: 1581. 28. Braga, M.F.M., Pereira, E.F.R., Eldefrawi, M., Albuquerque, E.X. (1999) α7 and α4β2 nicotinic receptors modulate spontaneous and evoked release of GABA from hippocampal neurons. Biophysics J. 76: A371, 1999. 29. Alkondon, M., Pereira, E.F.R., Eisenberg, H.M., Albuquerque, E.X. (1999) Excitation of CA1 interneurons by nicotinic receptor activation. Biophysics J. 76: A371. 30. Pereira, E.F.R., Braga, M.F.M., Albuquerque, E.X. (1999) α7- and α4β2-like nicotinic receptors (nAChRs) control glutamate and GABA release from hippocampal neurons in culture. Abstr. Soc. Neurosci. 25: 2241. 31. Priel, M.R., Pereira, E.F.R., Burt, D.R., Albuquerque, E.X. (1999) Acute effects of pilocarpine on rat hippocampal neurons. Abstr. Soc. Neurosci. 25: 1984. 32. Almeida, L.E.F., Pereira E.F.R., Albuquerque,.E.X. (1999) Naltrexone blocks the activity and the nicotine-induced upregulation of α7-like nicotinic receptors in hippocampal neurons. Abstr. Soc. Neurosci. 25: 2242. 33. Braga, M.F.M., Pereira E.F.R., Albuquerque, E.X. (1999) The modulation of GABA and glutamate release by nicotinic receptors (nAChRs) in hippocampal neurons is blocked by Pb2+. Abstr. Soc. Neurosci. 25: 2242. 34. Alkondon, M., Pereira, E.F.R., Eisenberg, H.M., Albuquerque, E.X. (1999) Nicotinic receptors in interneurons of the human cerebral cortex. Abstr. Soc. Neurosci. 25: 2238. 35. Braga, M.F.M., Pereira, E.F.R., Eldefrawi, M., Albuquerque, E.X. (1999) α7 and α4β2 nicotinic receptors modulate spontaneous and evoked release of GABA from hippocampus neurons. Biophysics J. 76: A371. 36. Alkondon, M., Pereira, E.F.R., Eisenberg, H.M., Albuquerque, E.X. (1999) Excitation of CA1 interneurons by nicotinic receptor activation. Biophysics J. 76: A371. 37. Camara, A.L., Pereira, E.F.R., Alkondon, M., Randall, W.R., Castro N.G., Albuquerque, E.X. (2000) Choline activates α-bungarotoxin-sensitive nicotinic receptors in ca1 pyramidal neurons of organotypic hippocampal cultures: regulation of receptor expression by septal innervation Abstr. Soc. Neurosci. 26: 1914. 38. Alkondon, M., Pereira, E.F.R., Randall W., Albuquerque, E.X. (2000) Nanomolar concentrations of nicotine modulate GABA release in rat hippocampal ca1 interneurons via activation and desensitization of nicotinic acetylcholine receptors. Abstr. Soc. Neurosci. 26: 1914. 39. Almeida, L.E.F., Pereira, E.F.R., Alkondon, M., Maelicke A., Albuquerque, E.X. (2000) The opioid antagonist naltrexone inhibits α7 and α4β2 nicotinic receptor activity and alters expression of functional receptors. Abstr. Soc. Neurosci. 26: 376. 40. Santos, M.D., Alkondon, M., Pereira, E.F.R., Aracava, Y., Engelhardt, E., Maelicke, A., Albuquerque, E.X. (2001) Galantamine potentiates synaptic 20

Pereira, Edna F.R. transmission in the mammalian brain. Abstr. Soc. Neurosci. #488.7. 41. Almeida, L.E.F., Pereira, E.F.R., Maelicke, A., Albuquerque, E.X. (2001) Expression of two nicotinic receptor isoforms in HEK293 cells stably transfected with α4 and β2 subunits. Abstr. Soc. Neurosci. #146.9. 42. Hilmas, C., Pereira, E.F.R., Alkondon, M., Rassoulpour, A., Schwarcz, R., Albuquerque, E.X. (2001) A reciprocal functional relationship between kynurenic acid and the nicotinic cholinergic system in the brain. Abstr. Soc. Neurosci. #376.1. 43. Pereira, E.F.R., Almeida, L.E.F., Fawcett, W.P., Randall, W.R., Albuquerque, E.X. (2001) Nicotine-induced up-regulation of α7 nicotinic receptors in cultured hippocampal neurons is developmentally regulated. Abstr. Soc. Neurosci. #145.2. 44. Camara, A.L., Pereira, E.F.R., Alkondon, M., Randall, W.R., Castro, N.G., Cintra, W.M., Albuquerque, E.X. (2001) Septal innervation of the hippocampus regulates expression of α7 nicotinic receptors in CA1 and CA3 pyramidal neurons. Abstr. Soc. Neurosci. #145.1. 45. Gonzalez-Serratos, H., Chang, R., Pereira, E.F.R., Castro, N.G., Aracava, Y., Melo, P.A., Lima, P.C., Fraga, C.A.M., Barreiro, E.J., Albuquerque, E.X. (2001) The novel thyenylhydrazone LASSBIO-294 increases inotropism and decreases fatigue of skeletal muscles. Abstr. Soc. Neurosci. #519.9. 46. Camara, A.L., Pereira, E.F.R., Castro, N.G., Fawcett, W.P., Randall, W.R., Albuquerque, E.X. (2002) α7 nicotinic receptor expression in CA1 and CA3 pyramidal neurons is regulated by septal innervation of the hippocampus. Abstr. Soc. Neurosci. #242.6. 47. Alkondon, M., Pereira, E.F.R., Albuquerque, E.X. (2002) Nicotinic receptor regulation of phasic and tonic NMDA receptor activities impinging upon CA1 interneurons of rat hippocampal slices. Abstr. Soc. Neurosci. #242.2. 48. Moon, E.K., Pereira, E.F.R., Albuquerque, E.X. (2002) Acetyl-L-carnitine potentiates nicotinic receptor activity and blocks tonic and phasic GABAergic activities in cultured hippocampal neurons. Abstr. Soc. Neurosci. #242.10, 2002. 49. Pereira, E.F.R., El-Nabawi, A., Eldefreawi, A.T., Albuquerque, E.X., Menegatti, R., Verli, H., Macchi, I.L., Lima, V.L.E., Neves, G.A., Viana, A.F., Fenner, R., Rates, S.M.K., Cunha, A.C., Ferreira, V.F., Rogrigues, C.R.M., Fraga, C.A.M., Berreiro, E.J. (2002) Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands. Abstr. Soc. Neurosci. #536.15. 50. Almeida, L.E.F., Pereira, E.F.R., Albuquerque, E.X. (2002) Prolonged exposure to nanomolar concentrations of nicotine synchronizes GABAergic synaptic activity. Abstr. Soc. Neurosci. #242.12. 51. Santos, M.D., Pereira, E.F.R., Aracava, Y., Castro, N.G., Albuquerque, E.X. (2002) Low concentrations of pyridostigmine prevent soman-induced inhibition of GABAergic transmission in the brain. Abstr. Soc. Neurosci. #837.5. 52. Alkondon, M., Pereira, E.F.R., Fawcett, W.P., Randall, W.R., Guidetti, P., Sapko, M.T., Yu, P., Tagle ,DA., Schwarcz, R., Albuquerque, E.X. (2003) Endogenous kynurenic acid regulates α7 nicotinic receptor activity in the hippocampus. Abstr. Soc. Neurosci. #9709. 53. Pereira, E.F.R., Crista, C., Randall, W.R., Albuquerque, E.X. (2003) Interactions between kynurenic acid and galantamine on a7 nicotinic receptors in hippocampal neurons. Abstr. Soc. Neurosci. #11419. 54. Gonzalez-Serratos, H., Pereira, E.F.R., Chang R., Barreiro E.J., Albuquerque, E.X. (2003) The thienylhydrazone, (2-thienylidene)3,4-methylenedioxybenzoylhydrazine (LASSBio-294), decreases fatigue and has a positive inotropic effect in mammalian skeletal muscle. Abstr. Soc. Neurosci. #13654. 55. Almeida, L.E.F., Albuquerque, E.X., Pereira, E.F.R. (2003) Compartmentalized nicotinic receptor subtypes control GABA release onto CA1 pyramidal neurons in the rat hippocampus. Abstr. Soc. Neurosci. #9809. 56. Popa, R., Pereira, E.F.R., Cintra, W.M., Maelicke, A., Albuquerque, E.X. (2003) At 21

Pereira, Edna F.R. clinically relevant concentrations galantaminone, a metabolite of galantamine, does not affect α7 nicotinic receptor activity in hippocampal neurons. Abstr. Soc. Neurosci. #9433. 57. Albuquerque, E.X., Pereira, E.F.R., Alkondon, M. (2003) Contribution of NMDA and AMPA receptors to the nicotinic cholinergic excitation of CA1 interneurons in the rat hippocampus. Abstr. Soc. Neurosci. # 9570. 58. Pereira, E.F.R., Braga, M.F.M., Mike, A., Albuquerque, E.X. (2004) Pb2+ via protein kinase c blocks nicotinic cholinergic modulation of synaptic transmission in the hippocampus. Abstr. Soc. Neurosci. #952.14. 59. Gonzalez-Serratos, H., Pereira, E.F.R., Chang, R., Melo, P.A., Castro, N.G., Barreiro, E.J., Albuquerque E.X. (2004) The thienylhydrazone derivative (2- thienylidene)3,4-methylenedioxybenzoylhydrazine (lassbio-294) selectively decreases fatigue of slow-twitch fibers: a study in adult rat diaphragm and developing rat extensor digitorum longus. Abstr. Soc. Neurosci. #838.2. 60. Oliveira, M., Gary, T.M., Fawcett, W.P., Randall, W.R., Albuquerque, E.X., Pereira, E.F.R. (2004) Neuroprotective effects of galantamine, a drug used to treat alzheimer’s disease, in primary hippocampal cultures. Abstr. Soc. Neurosci. #216.15. 61. Almeida, L.E.F., Oliveira, M., Albuquerque, E.X., Pereira, E.F.R. (2004) Functional and structural modifications in the rat hippocampus exposed to a single dose of nicotine in vitro and in vivo. Abstr. Soc. Neurosci. # 48.10. 62. Aracava, Y., Pereira, E.F.R., Maelicke, A., Albuquerque, E.X. (2004) Clinically relevant concentrations of memantine block more potently α7 nicotinic than NMDA receptors: Implications in Alzheimer’s disease treatment. Abstr. Soc. Neurosci. #48.24. 63. Arruda, E.Z., Pereira, E.F.R., Alkondon, M., Cintra, W.M., Guidetti, P., Randall, W.R., Schwarcz, R., Tagle, D., Albuquerque, E.X. (2004) Acting via α7 nicotinic receptors endogenous kynurenic acid (KYNA) regulates gabaergic transmission in the hippocampus: a knockout study. Abstr. Soc. Neurosci. # 48.9. 64. Caminha, I., Burt, D.R., Albuquerque, E.X., Pereira, E.F.R. (2005) Tamoxifen at clinically relevant concentrations causes significant inhibition of α7 nicotinic receptor activity in hippocampal neurons. Abstr. Soc. Neurosci. #953.9. 65. Oliveira, M., Arruda, E.Z., Pereira, E.F.R., Guidetti, P., Schwarcz, R., Albuquerque, E. X. (2005) Dendritic morphology of hippocampal CA1 pyramidal neurons is regulated by endogenous levels of kynurenic acid. Abstr. Soc. Neurosci. #953.10. 66. Arruda, E.Z., Pereira, E.F.R., Weinreich, D., Guidetti, P., Schwarcz, R., Albuquerque E.X. (2005) Endogenous kynurenic acid regulates glutamatergic synaptic activity impinging onto CA1 pyramidal neurons. Abstr. Soc. Neurosci. #953.11. 67. Pereira, E.F.R., Oliveira, M., Almeida, L.E.F., Albuquerque, E.X. (2005) In vivo studies of the effects of nicotine on neuronal hippocampal circuitries. Abstr. Soc. Neurosci. #954.3. 68. Fawcett, W.P., Pereira, E.F.R., Aracava, Y., Oliveira, M., Randall, W.R., Adler, M., Romano, J., Albuquerque, E.X. (2005) An in vivo analysis of the effects of galantamine in guinea pigs. Abstr. Soc. Neurosci. # 954.11. 69. Alkondon, M., Pereira, E.F.R., Albuquerque, E. X. (2006) Strain-specific nicotinic cholinergic modulation of glutamate transmission in the CA1 field of the rat hippocampus. Abstr. Soc. Neurosci. #326.4. 70. Caminha, I., Albuquerque, E. X., Pereira. E.F.R. (2006) Tamoxifen at clinically relevant concentrations inhibits α7 nicotinic receptor activity in hippocampal neurons: a possible mechanism for memory impairment. Abstr. Soc. Neurosci. #524.1. 71. Lopes, C., Pereira, E.F.R., Schwarcz, R., Burt, D.R., Albuquerque, E. X. (2006) Interactions between galantamine and kynurenic acid on α7 nicotinic receptors in 22

Pereira, Edna F.R. hippocampal and striatal neurons. Abstr. Soc. Neurosci. #524.4. 72. Aracava, Y., Pereira, E.F.R., Fawcett, W.P., Oliveira, M., Randall, W. R., Hamilton, T. Kan, R. K., Adler, M., Romano, Jr., J. A., Albuquerque, E. X. (2006) An effective countermeasure against poisoning by organophosphorus insecticides and nerve agents. Abstr. Soc. Neurosci. #684.17. 73. Karnup, S.V., Nagode, D.A., Aracava, Y., Pereira, E.F.R., Albuquerque, E.X. (2007) Effects of antidotal galantamine dose on synaptic transmission in hippocampus and basolateral amygdale. Abstr. Soc. Neurosci. #471.25. 74. Alexandrova, E., Randall, W.R., Aracava, Y, Pereira, E.F.R., Albuquerque, E.X. (2007) Effects of galantamine on spontaneous inhibitory and excitatory postsynaptic currents in hippocampal CA1 pyramidal cells of guinea pigs challenged with soman. Abstr. Soc. Neurosci. #144.17. 75. Aracava, Y., Pereira, E.F.R., Wu, H.-Q., Guidetti, P., Potter, M.C., Schwarcz, R., Albuquerque, E.X. (2007) Endogenous kynurenic acid modulates glutamatergic transmission between Schaffer collaterals and CA1 pyramidal neurons. Abstr. Soc. Neurosci. #39.10. 76. Gullapalli, R., Aracava, Y., Helal-neto, E., Makris, G., Zhuo, J., Pereira, E.F.R., Albuquerque, E.X. (2007) Magnetic resonance imaging (MRI) reveals that galantamine effectively prevents morphological changes in the brain of guinea pigs challenged with lethal doses of soman. Abstr. Soc. Neurosci. #903.6. 77. Alkondon, M., Pereira, E.F.R., Albuquerque, E.X. (2007) Functional a7 nicotinic acetylcholine receptors are present in CA1 stratum radiatum interneurons in the hippocampus of guinea pigs. Abstr. Soc. Neurosci. #573.3. 78. Merchenthaler, I., Aracava, Y., Puskar, A., Pereira, E.F.R., Albuquerque, E.X. (2007) Galantamine prevents organophosphorus-induced cell death in the guinea pig telencephalon. Abstr. Soc. Neurosci. #903.5. 79. Kulkarni, G., Pereira, E.F.R., Albuquerque, E.X. (2007) Effects of memantine, galantamine, and donepezil in the hippocampus of APP/PS1 mice, an animal model of Alzheimer’s disease. The Toxicologist 96: 216. 80. Pereira, E.F.R., Fawcett, W.P., Aracava, Y., Akkerman, M., Helal, R., Adler, M., Albuquerque, E.X. (2008) Galantamine counteracts neurodegeneration induced by nerve agents. Proceedings of the 2008 Bioscience Review Meeting. 81. Albuquerque, E.X., Pereira, E.F.R., Fawcett, W.P., Aracava, Y., Akkerman, M., Helal, R., Adler, M. (2008) Galantamine: A novel therapeutic approach to nerve agent poisoning. Proceedings of the 2008 Bioscience Review Meeting. 82. Albuquerque, E.X., Pereira, E.F.R., Fawcett, W.P., Aracava, Y., Akkerman, M., Helal, R., Helal-Neto, E., Alexandrova, E., Karnup, S., Gullapalli, R., Merchenthaler, I., Adler, M. (2008) Age and sex effects on nerve agent damage to the brain and antidotal therapies. 4th Annual Meeting of the CounterACT Program. 83. Aracava, Y., Akkerman, M., Helal,R., Pereira, E.F.R., Adler, M., Albuquerque, E.X. (2008) Effectiveness of donepezil, rivastigmine and (±)huperzine A in preventing the lethality and acute toxicity of organophosphorus nerve agents: Comparison with galantamine. Abstr. Soc. Neurosci. #753.7. 84. Karnup, S.V., Nagode, D.A., Aracava, Y., Pereira, E.F.R., Albuquerque, E.X. (2008) Galantamine attenuates the potentiating effect of soman on long-term potentiation in the guinea pig hippocampus. Abstr. Soc. Neurosci. #431.7. 85. Nagode, D.A., Randall, W.R., Fawcett, W.P., Albuquerque, E.X., Pereira, E.F.R. (2008) Mechanisms underlying differences in the sensitivity of blood and brain acetylcholinesterase to inhibition by galantamine. Abstr. Soc. Neurosci. #431.13. 86. Albuquerque, E.X., Aracava, Y., Akkerman, M., Helal, R., Pereira, E.F.R., Adler, M. (2008) Age and sex differences in the sensitivity of guinea pigs to the acute toxicity and lethality of the nerve agents soman, and VX. Abstr. Soc. Neurosci. #753.2. 87. Alexandrova, E., Aracava, Y., Pereira, E.F.R., Albuquerque, E.X. (2008) 23

Pereira, Edna F.R. Galantamine counteracts changes in inhibitory synaptic transmission in the CA1 field of the hippocampus of guinea pigs. Abstr. Soc. Neurosci. #129.9. 88. Alkondon, M., Pereira, E.F.R., Aracava, Y., Albuquerque, E.X. (2008) Factors that influence α7 nicotinic receptor activity in CA1 interneurons of guinea pig hippocampal slices: Effects of a single injection of the cholinesterase inhibitors soman and galantamine. Abstr. Soc. Neurosci. #328.4. 89. Albuquerque, E.X., Mamczarz, J., Aracava, Y., Fawcett, W.P., Akkerman, M., Adler, M., Pereira, E.F.R. (2009) Age and sex effects on nerve agent damage to the brain and antidotal therapies. 5th Annual Meeting of the CounterACT Program. 90. Alexandrova, E.A., Aracava, Y., Pereira, E.F.R., Albuquerque, E.X. (2009) Pretreatment with galantamine of soman-challenged guinea pigs decreases spontaneous glutamatergic transmission impinging onto CA1 pyramidal neurons. Abstr. Soc. Neurosci. #717.19. 91. Kulkarni, G., Akkerman, M., Pereira, E.F.R., Albuquerque, E.X. (2009) Signaling mechanisms that can contribute to the neuroprotection afforded by galantamine in guinea pigs exposed to a single dose of the organophosphorus compound soman. Abstr. Soc. Neurosci. #153.2. 92. Mamczarz, J., Aracava, Y., Pereira, E.F.R., Albuquerque, E.X. (2009) Galantamine prevents development of learning impairment in soman-challenged guinea pigs. Abstr. Soc. Neurosci. #887.7. 93. Alkondon, M., Pereira, E.F.R., Schwarcz, R., Albuquerque, E.X. (2009) Opposite effects of L-kynurenine on a7 nicotinic acetylcholine receptor activity in hippocampals slices from neonatal and prepuberal rats. Abstr. Soc. Neurosci. #34.10. 94. Aracava, Y., Akkerman, M., Pereira, E.F.R., Albuquerque, E.X. (2009) Effectiveness of galantamine/ as an antidote against multiple lethal doses of the nerve agents soman, sarin and VX. Abstr. Soc. Neurosci. #829.10. 95. Albuquerque, E.X., Mamczarz, J., Gullapalli, R., Xu, S., Aracava, Y., Fawcett, W.P., Akkerman, M., Pereira, E.F.R. (2010) Age and sex effects on nerve agent damage to the brain and antidotal therapies. 6th Annual Meeting of the CounterACT Program. 96. Alkondon, M., Banerjee, J., Pereira, E.F.R., Schwarcz, R., Albuquerque, E.X. (2010) Elevating the level of endogenous kynurenic acid suppresses α7 nicotinic receptor (nAChR) and tonic NMDA activities in rat hippocampal slices. Abstr. Soc. Neurosci. #39.8. 97. Alexandrova, E., Pereira, E.F.R., Albuquerque, E.X. (2010) Contribution of AMPA and kainate receptors to excitatory postsynaptic currents recorded from CA1 stratum pyramidale interneurons in hippocampal slices from guinea pigs. Abstr. Soc. Neurosci. #238.13. 98. Pereira, E.F.R., Akkerman, M., Aracava, Y., Randall, W.R., Albuquerque, E.X. (2010) Epigenetic changes induced by developmental exposure of guinea pigs to chlorpyrifos. Abstr. Soc. Neurosci. #441.23. 99. Mamczarz, J., Pereira, E.F.R., Aracava, Y., Albuquerque, E.X. (2010) Treatment with galantamine prevents development of learning impairment in guinea pigs challenged with the nerve agent sarin. Abstr. Soc. Neurosci. #611.11. 100. Albuquerque, E.X., Mamczarz, J., Aracava, Y., Pereira, E.F.R. (2010) Galantamine effectively counteracts the delayed behavioral impairments induced by a single exposure of guinea pigs to low levels of the organophosphorus nerve agent sarin or VX. Abstr. Soc. Neurosci. #885.13. 101. Kulkarni, G., Akkerman, M., Aracava, Y., Albuquerque, E.X., Pereira, E.F.R. (2011) Signaling mechanisms that can contribute to the neuroprotection afforded by galantamine in guinea pigs exposed to the nerve agent soman. The Toxicologist 120: 436. 102. Mamczarz, J., Aracava, Y., Pereira, E.F.R., Albuquerque, E.X. (2011) Galantamine 24

Pereira, Edna F.R. counteracts cognitive deficits in guinea pigs challenged with the nerve agent sarin. The Toxicologist 120: 436. 103. Alexandrova, E., Pereira, E.F.R., Kristan, T. Adler, M., Albuquerque, E.X. (2011) A single injection of the organophosphorus poison soman causes sutained inhibition of excitatory drive of CA1 pyramidal neurons in guinea pigs. Abstr. Soc. Neurosci. # 256.14. 104. Aracava, Y., Kulkarni, G., Pereira, E.F.R., Albuquerque, E.X. (2011) Comparison of the effectiveness of galantamine and pyridostigmine as antidotes against the toxicity of sarin: Electroencephalographic (EEG) recordings and Fluoro Jade-B staining. Abstr. Soc. Neurosci. #367.07. 105. Alkondon, M., Pereira, E.F.R., Aracava, Y., Albuquerque, E.X. (2011) Acetylcholinesterase inhibition by soman reveals endogenous nicotinic cholinergic modulation of AMPA EPSCs in guinea pig CA1 stratum radiatum interneurons. Abstr. Soc. Neurosci. #367.08. 106. Mamczarz, J., Gavrushenko, L, Aracava, Y., Pereira, E.F.R., Albuquerque, E.X. (2011) Delayed effects of a single exposure to the organophosphorus pesticide chlorpyrifos on emotional and cognitive behavior in guinea pigs. Abstr. Soc. Neurosci. #367.10. 107. Randall, W.R., Pereira, E.F.R., Akkerman, M., Albuquerque, E.X. (2011) Histone acetylation induced by exposure to organophosphorus agents in guinea pig brain is prevented by treatment with galantamine. Abstr. Soc. Neurosci. #367.11. 108. Kulkarni, G., Pereira, E.F.R., Margolis, F.L., Albuquerque, E.X. (2011) Neuroprotection afforded by galantamine in guinea pigs exposed to the organophosphorus poison soman. Abstr. Soc. Neurosci. #367.17. 109. Fawcett, W.P., Pereira, E.F.R., Aracava, Y., Adler, M., Albuquerque, E.X. (2011) Effects of low-level nerve agent exposure and galantamine on acetylcholinesterase activity in vivo. Abstr. Soc. Neurosci. #367.18. 110. Banerjee, J., Alkondon, M., Pereira, E.F.R., Albuquerque, E.X. (2011) Kynurenic acid disrupts modulation by α7 nicotinic receptors of GABAergic synaptic transmission to CA1 pyramidal neurons in the rat hippocampus. Abstr. Soc. Neurosci. #657.03. 111. Mullins, R.J., Xu, S., Pereira, E.F.R., Albuquerque, E.X., Gullapalli R. (2012) Early disruption of the structural and metabolic integrity of the brain following an acute exposure of guinea pigs to VX: An MRI/MRS study. Abst. Soc. Neurosci. #65.19. 112. Banerjee, J., Alkondon, M., Pereira, E.F.R., Albuquerque, E.X. (2012) α7 nicotinic (nAChR)-dependent and -independent glutamatergic input to CA1 pyramidal neurons is inhibited by kynurenic acid. Abstr. Soc. Neurosci. #137.13. 113. Alexandrova, E.A., Pereira, E.F.R., Aracava, Y., Albuquerque, E.X. (2012) Galantamine prevents long-lasting reduction of AMPA-mediated excitatory postsynaptic currents in CA1 pyramidal neurons of guinea pigs challenged with the organophosphorus poison soman. Abstr. Soc. Neurosci. #537.17. 114. Dowlati, E., Hawkins, C., Aracava, Y., Basinger, G.W. Jr., Pereira, E.F.R., Mamczarz, J., Albuquerque, E.X. (2012) Dose dependency of the effectiveness of galantamine to counter the neurotoxicity of the organophosphorus poison VX. Abstr. Soc. Neurosci. #840.01. 115. Gavrushenko, L., Pescrille, J.D., Pereira, E.F.R., Albuquerque, E.X., Mamczarz, J. (2012) Effect of prenatal exposure to chlorpyrifos on cognitive performance of guinea pigs. Abstr. Soc. Neurosci. #840.02. 116. Burke, R.D., Albuquerque, E.X., Pereira, E.F.R. (2012) In utero chlorpyrifos exposure leads to augmented CA1 pyramidal GABAergic transmission in the adult male guinea pig. Abstr. Soc. Neurosci. #840.03. 117. Aracava, Y., Adler, M., Kulkarni, G., Hunt, J.R., Pereira, E.F.R., DeTolla, L., Albuquerque, E.X. (2012) Effectiveness of galantamine and pyridostigmine to prevent the acute toxicity of the organophosphorus nerve agent sarin: Telemetric 25

Pereira, Edna F.R. EEG recordings and Fluoro-Jade staining. Abstr. Soc. Neurosci. #840.04. 118. Coombes, R.H., Hunt, J.R., Aracava, Y., Banerjee, J., Pereira, E.F.R., Albuquerque, E.X., Fawcett, W.P. (2012) Effects of an acute exposure to the organophosphorus poison VX on the pharmacokinetics of galantamine in guinea pigs. Abstr. Soc. Neurosci. #840.05. 119. Pescrille, J., Gavrushenko, L., Aracava ,Y., Pereira, E.F.R., Albuquerque, E.X., Mamczarz, J. (2012) Effect of prenatal exposure to soman on cognitive performance of guinea pigs. Abstr. Soc. Neurosci. #840.06. 120. Pereira, E.F.R., Pescrille, J.D., Gavrushenko, L., Gammans, R., Mamczarz, J., Albuquerque, E.X. (2012) Cognitive impairment in adult male guinea pigs long after an acute exposure to the organophosphorus poison soman. Abstr. Soc. Neurosci. #840.07. 121. Alkondon, M., Banerjee, J., Pereira, E.F.R., Regenold, W.T., Albuquerque, E.X. Tonically active α7 nicotinic receptors (nAChRs) regulate glutamate synaptic activity in CA3 pyramidal neurons to maintain glutamatergic input to CA1 pyramidal neurons. Abstr. Soc. Neurosci. #840.08. 122. Albuquerque, E.X., Pereira, E.F.R, Gould, T.D., Alkondon, M. (2012) Kynurenic acid and tonically active nicotinic receptors modulate resting excitability of CA1 stratum radiatum interneurons in rat hippocampal slices. Abstr. Soc. Neurosci. #840.09. 123. Randall, W.R., Xu, R., Pereira, E.F.R., Albuquerque, E.X. (2012) Long-lasting histone modifications are detected in the brains of young adult guinea pigs exposed in utero to the organophosphorus pesticide chlorpyrifos. Abstr. Soc. Neurosci. #840.10. 124. Hunt, J.R., Alexandrova, E., Aracava, Y., Pereira, E.F.R., Albuquerque, E.X. (2012) An acute exposure to the organophosphorus poison VX shortens sleep episodes in guinea pigs: An electroencephalographic (EEG) analysis. Abstr. Soc. Neurosci. #840.11. 125. Sours, C.R., Alkondon, M., Pereira, E.F.R., Aracava, Y., Albuquerque, E.X. (2012) Acetylcholinesterase inhibition increases the activity of both α7 and non-α7 nAChRs in hippocampal slices. Abstr. Soc. Neurosci. #840.12. 126. Mamczarz, J., Pescrille, J.D., Gavrushenko, L., Aracava, Y., Beecham, E.J., Pereira, E.F.R., Albuquerque, E.X. (2012) Post-treatment with galantamine effectively counters cognitive impairment induced by exposure of adult male guinea pigs to high levels of the organophosphorus poisons soman or sarin. Abstr. Soc. Neurosci. #840.13. 127. Burke, R.D., Pescrille, J.D., Mamczarz, J., Albuquerque, E.X., Pereira, E.F.R. (2013) In-utero chlorpyrifos exposure leads to behavioral deficits and alterations in hippocampal GABAergic synaptic transmission in the adult male guinea pig. Abstr. National Capital Area Chapter of the Society of Toxicology. 128. Todd, S.W., Randall, W.R., Pereira, E.F.R., Pescrille, J.D., Mamczarz, J., Albuquerque, E.X. (2013) Prenatal exposure to sub-acute levels of chlorpyrifos leads to p38 dysfunction and epigenetic modifications in the brain. Abstr. National Capital Area Chapter of the Society of Toxicology. 129. Albuquerque, E.X., Aracava, Y., Pescrille, J.D., Gavrushenko, L., Mamczarz, J., Alexandrova, E., Mullins, R.J., Xu, S., Gullapalli, R., Pereira, E.F.R. (2013) Age and sex effects on nerve agent damage to the brain and antidotal therapies. 8th Annual Meeting of the CounterACT Program. 130. Albuquerque, E.X., Pereira, E.F.R., Alkondon, M (2013) Tonic activation of α7 nicotinic acetylcholine receptors (nAChRs) controls glutamatergic inputs to striatal and parietal cortical neurons in guinea pig brain slices. Abstr. Soc. Neurosci. #224.01. 131. Alkondon, M., Pereira, E.F.R., Albuquerque, E.X. (2013) Presence of non-α7 nAChRs in CA1 pyramidal neurons in rat hippocampal slices. Abstr. Soc. Neurosci. 26

Pereira, Edna F.R. #224.02. 132. Mamczarz, J., Pereira, E.F.R., Cole, E., McCowan, L., Aracava, Y. Albuquerque, E.X. (2014) Exposure of adult female guinea pigs to the nerve agent VX reduces their flexibility in using different navigation strategies in the Morris water maze. Abstr. Soc. Neurosci. #360.09. 133. Aracava, Y., Pereira, E.F.R., Lane, M., Clark, R.J., Basinger Jr., G.W., Albuquerque, E.X. (2014) Galantamine as an effective pre-treatment countermeasure against high doses of soman: Comparison with pyridostigmine efficacy. Abstr. Soc. Neurosci. #423.10. 134. Alexandrova, E., Aracava, Y., Pescrille, J.D., Richardson, L.D., Gushen, B., Pereira, E.F.R., Albuquerque, E.X. (2014) Effects of galantamine post-treatment on nerve agent-induced EEG changes and lethality of rats. Abstr. Soc. Neurosci. #423.11. 135. Todd, S.W., Randall, W.R., Pereira, E.F.R., Albuquerque, E.X. (2014) Prenatal exposure to Chlorpyrifos leads to reduced msk expression in the dentate gyrus: Implications for regulation of histone acetylation. Abstr. Soc. Neurosci. #423.12. 136. Burke, R.D., Albuquerque, E.X., Pereira, E.F.R. (2014) In utero exposure to the pesticide chlorpyrifos leads to augmented gabaergic synaptic transmission and gliosis in the guinea pig hippocampus. Abstr. Soc. Neurosci. #423.13. 137. Fawcett, W.P., Coombes, R.H., Aracava, Y., Wakayama, E.J., Basinger, G.W., Albuquerque, E.X., Pereira, E.F.R. (2014) The pharmacokinetics of galantamine in adult male rats is not affected by the organophosphorus nerve agent sarin or by atropine, , and . Abstr. Soc. Neurosci. #423.15. 138. Randall, W.R., Pereira, E.F.R., Albuquerque, E.X. (2014) Long-lasting histone acetylation of pyramidal neurons are detected in the hippocampus of young adult guinea pigs exposed in utero to the organophosphorus pesticide chlorpyrifos. Abstr. Soc. Neurosci. #423.16. 139. Alkondon, M., Pereira, E.F.R., Todd, S.W., Lane, M. Albuquerque, E.X. (2014) Functional G-protein coupled receptor 35 (GPR35) in rat hippocampal CA1 stratum radiatum interneurons. Abstr. Soc. Neurosci. #502.18. 140. Aracava, Y., Pescrille, J.D., Carter, D., Clark, R., Richardson, L., Lane, M., Pereira E.F.R., Albuquerque, E.X., Basinger Jr., G.W. (2015) Efficacy of oral galantamine pre-treatment against soman toxicity in guinea pigs. Abstr. Soc. Neurosci. #500.15. 141. Fawcett, W.P., Coombes, R.H., Aracava, Y., Pescrille, J.D., Basinger Jr., G.W., Pereira, E.F.R., Albuquerque, E.X. (2015) Pharmacokinetics of galantamine following oral administration to guinea pigs. Abstr. Soc. Neurosci. #500.16. 142. Pereira, E.F.R., Aracava, Y., Pescrille, J.D., Carter, D., Richardson, L., McKoy, D., McCowan, L., Alexandrova, E., Pham, N. Lumsden, E., Clark, R., Mamczarz, J., Xu, S., Gullapalli, R.P., Lane, M., Merchenthaler, I., Basinger Jr., G.W., Albuquerque, E.X. (2015) Galantamine as an effective co-adjuvant medical countermeasure to counter the delayed neurotoxic effects of the organophosphorus compound sarin. Abstr. Soc. Neurosci. #500.17. 143. Todd, S.W., Pereira, E.F.R., Randall, W.R., Albuquerque, E.X. (2017) Effects of continuous exposure to chlorpyrifos on SH-SY5Y cell differentiation: Implications for developmental neurotoxicity. The Toxicologist 3465. 144. Todd, S.W., Lumsden, E., Randall, W.R., Albuquerque, E.X., Pereira, E.F.R. (2018) Chlorpyrifos induces neuronal differentiation of SH-SY5Y neuroblastoma cells. The Toxicologist 2272. 145. Aracava, Y., Albuquerque, E.X., Pereira, E.F.R. (2019) Inhibition of α7 nicotinic receptors by R,S-: Relevance for treatment of organophosphorus intoxication. Abstr. Soc. Neurosci. #201.18 146. Todd, S.W., Lumsden, E., Randall, W.R., Krueger, B.K., Albuquerque, E.X., Pereira, E.F.R. (2019) Effects of the organophosphorus insecticide chlorpyrifos on neuronal differentiation of the SH-SY5Y cell line: Involvement of cannabinoid type 1 27

Pereira, Edna F.R. receptors. Abstr. Soc. Neurosci. #639.24. 147. Lumsden, E.W., Burke, R.D., Albuquerque, E.X., Pereira, E.F.R. (2019) In vitro modeling of the disruptive effects of the organophosphorus insecticide chlorpyrifos on synaptic transmission in the developing hippocampus. Abstr. Soc. Neurosci. #639.26.

International

1. Pereira, N.A., Pereira, E.F.R., Freitas, A.C.C., Barreiro, E.J. (1989) Analgesic and antiinflamaory activities of new pyrazolic compounds. Abstr. 3rd Braz. Meeting on Organic Synthesis. 2. Pereira, N.A., Pereira, E.F.R., Carneiro, C.M.T.S. (1988) Study of edema and enhanecement of vascular permeability induced by extract of Dieffenbachia picta Schott, Aracea. Abstr. 10th Symposium on in Brazil. 3. Freitas, A.C.C., Barreiro, E.J., Pereira A.L., Silva, F.S.Q., Vianna, V.V., Pereira, E.F.R. (1989) Synthesis and preliminary pharmacological evaluation of new 5- amino and 5-hydrazone pyrazoles as antiinflamatory and analgesic agents. Abstr. 3rd Braz. Meeting on Organic Synthesis. 4. Pereira, N.A., Pereira, E.F.R., Barreiro, E.J., Freitas, A.C.C., Quirino, F. (1989) Analgesic and antiinflamatory of new pyrazolic derivatives. Abstr. 4th Annual Meeting of Federation of Biological Experimental Societies. 5. Ruppelt, B.M., Pereira, E.F.R., Gonçalves, L.G., Pereira N.A. (1989) Pharmacological screening of plants recommended by folk medicine as anti- . I. Analgesic and anti-inflammatory activities. Abstr. Sino- Brazilian Symposim on Natural Products. 6. Pereira, E.F.R., Alkondon, M., Castro, N., Tano, T., Maelicke, A., Albuquerque, E.X. (1992) Functional characterization of a second agonist binding site on nicotinic acetylcholine receptors (nAChRs). 5th Swiss Workshop of Methodology in Receptor Research. 7. Albuquerque, E.X., Pereira, E.F.R., George, P.G., Horton, R.M., Conti-Tronconi, B.M., Grando, S.A. (1994) Receptores nicotínicos neuronais expressos em células epiteliais controlam adesividade e motilidade celular e constituem alvo para anticorpos presentes no soro de pacientes postadores de Pemphigus. Reunião Anual da Federação de Sociedades de Biologia Experimental, 14.017. 8. Albuquerque, E.X., Alkondon, M., Bonfante-Cabarcas, R., Pereira, E.F.R., Maelicke, A. (1995) Functional diversity of neuronal nicotinic receptors. Ninth International Symposium on Cholinergic Mechanisms. Mainz, Germany. 9. Albuquerque, E.X., Pereira, E.F.R., Aracava, Y., Rocha, E.S., Braga, M.F.M. Barbosa, C.T.F., Eisenberg, H., Alkondon, M. (1996) Produtos naturais: Ferramentas que desvendam a função dos receptores nicotínicos e sua relação fisiopatológica. FeSBE, Caxambu, MG, Brazil. 10. Almeida, L.E.F., Pereira, E.F.R., Albuquerque. (1997) Naltrexona, um antagonista opióide, bloqueia receptores nicotínicos (nAChRs) presentes em neurônios hipocampais. FeSBE, Caxambu, MG, Brazil. 11. Pereira, E.F.R., Cardoso, C.R., Barreiro, E.J., Albuquerque, E.X. (1998) Um novo analogo estrutural dos benzodiazepinicos bloqueia o efeito potencializador do diazepam sobre as correntes macroscopicas ativadas pelo GABA em neurônios hipocampais. FeSBE, Caxambu, MG, Brazil p. 305. 12. Braga, M.F.M., Peçenha, E.P., Pereira, E.F.R., Berreiro, E.J., Albuquerque, E.X. (1998) Um novo análogo do GABA potencializa a neurotransmissão GABAérgica e inibe a glutamatérgica em neurônios hipocampais. FeSBE, Caxambu, MG, Brazil, p. 305. 13. Almeida, L.E.F., Peçenha, E.P., Pereira, E.F.R., Barreiro, E.J., Aracava, Y., Albuquerque, E.X. (1998) Um novo análogo estrutural do GABA atua como 28

Pereira, Edna F.R. antagonista dos receptores GABAA em neurônios hipocampais. FeSBE, Caxambu, MG, Brazil, p. 306. 14. Pereira, E.F.R., Moon, E.K., Albuquerque, E.X. (2002) Neuronal nicotinic receptors and GABAA receptors are targets for acetyl-L-carnitine in hippocampal neurons. Reunião da Soc. Brasileira de Farmacol. Terapêutica Experimental (SBFTE), Águas de Lindόia, MG, Brazil, p. 107. 15. Hilmas, C., Pereira, E.F.R., Albuquerque, E.X. (2002) The actions of drugs on α7 nicotinic receptors in hippocampal neurons. Reunião da Soc. Brasileira de Farmacol. Terapêutica Experimental (SBFTE), Águas de Lindόia, Brazil, p. 107. 16. Aracava, Y. Pereira, E.F.R., Maelicke, A., Albuquerque, E.X. (2004) α7 nicotinic receptors are blocked more potently than NMDA receptors by clinically relevant concentrations of memantine: Implications for treatment of Alzheimer’s disease. Proceedings II Congress on Neuroregeneration, September, Rio de Janeiro, RJ, Brazil. 17. Pereira, E.F.R., Fawcett, W.P., Aracava, Y., Akkerman, M., Helal, R., Nagode, D., Randall, W.R., Gullappalli, R., Adler, M., Albuquerque, E.X. (2008) Molecular and cellular actions of galantamine: Clinical implications for treatment of neurological diseases and organophosphorus poisoning. XIII International Symposium on Cholinergic Mechanisms, Foz do Iguaçu, Brazil.

Invited Speeches

1. Pereira E.F.R. Detrimental Health Effects of Gestational Exposures to Organophosphorus Insecticides. College of Veterinary Medicine, Iowa State University, 2021. 2. Pereira, E.F.R. From the Reticular Formation to the Neuromuscular Junction and the Brain. XVIth International Symposium on Cholinergic Mechanisms. Rehovot, Israel, 2019. 3. Pereira, E.F.R. Developmental Neurotoxicity of Organophosphorus Pesticides: From Sex Dimorphism to Molecular Mechanisms. 21st U.S. Army Medical Defense Bioscience Review. Aberdeen, MD, 2018. 4. Pereira, E.F.R. Developmental Neurotoxicity of Soman in Guinea pigs. 19th Biennial Medical Chemical Defense Bioscience Review. Hunt Valley, MD, 2014. 5. Pereira, E.F.R. Developmental Neurotoxicity of Nerve Agents. 7th Annual CounterACT Network Research Symposium, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Washington DC, 2013. 6. Pereira, E.F.R. Mechanisms of Organophosphorus Intoxication. XIII International Symposium on Cholinergic Mechanisms, August, Foz do Iguaçu, MG, Brazil, 2008. 7. Pereira, E.F.R. Molecular Mechanisms Underlying the Toxicity of Organophosphorus (OP) Compounds and the Effectiveness of Galantamine as a Countermeasure for OP Poisoning. 15th Biennial Medical Chemical Defense Bioscience Review. Hunt Valley, MD, 2006. 8. Pereira, E.F.R. Effects of Prenatal Exposure to Nicotine on Synaptic Activity and Neuronal Structure in the CA1 Field of the Hippocampus: Involvement of α7 Nicotine Receptors. 4th Annual Scientific Forum, University of Maryland School of Medicine, Baltimore, MD, 2005. 9. Pereira, E.F.R. Functional and Structural Changes Induced by Nicotine in the Hippocampus. Satellite symposim on tobacco research. Key West, Fl, 2004. 10. Pereira, E.F.R. The Nicotinic Allosteric Potentiating Ligand Galantamine and Nicotine on Neuronal Connectivity and Neurodegeneration in the Mammalian Brain. II Congress on Neuroregeneration, September, Rio de Janeiro, RJ, Brazil, 2004. 11. Pereira E.F.R. Pb2+ Inhibits Nicotinic Cholinergic Modulation of Synaptic Transmission in the Hippocampus: Toxicological Implications. 2004 Summer 29

Pereira, Edna F.R. Research Program for Undergraduate Students. University of Maryland School of Medicine. Baltimore, MD, 2004. 12. Pereira, E.F.R. Age-Dependent Effects of Neuronal Circuities in the Hippocampus: Clinical Implications. Inaugural Scientific Forum on Cancer and Other Tobacco- Related Diseases, Maryland Cigarette Restitution Fund Program, University of Maryland School of Medicine, Baltimore, MD, 2003. 13. Pereira, E.F.R. Effects of the Nicotinic Allosteric Potentiating Ligand Galantamine on Synaptic Transmission in the Central Nervous System: Implications for the Treatment of Alzheimer's Disease. June, Stockholm, Sweden, 2002. 14. Pereira, E.F.R. Modulation of Function and Expression of Nicotinic Receptors in the Mammalian Central Nervous System. International Meeting of the Latin American Societies of Biological Sciences, Águas de Lindóia, MG, Brazil, 2000. 15. Pereira, E.F.R. Nicotinic Receptors in the Mammalian Central Nervous System. Drug Development for the 21st Century. Departmento de Farmacologia Básica e Clínica, Universidade Federal do Rio de Janeiro, August, Rio de Janeiro, RJ, Brazil, 1998. 16. Pereira, E.F.R. Modulation of Nicotinic Receptor Functions by Allosteric Ligands. Inst. Biofísica Carlos Chagas Filho”, Universidade Federal do Rio de Janeiro, August, Rio de Janeiro, RJ, Brazil, 1996. 17. Pereira, E.F.R. Fundamentals of Basic and Clinical Pharmacology. Hospital Universitário Antônio Pedro. Universidade Federal Fluminense, Rio de Janeiro, RJ, Brazil, 1988. 18. Pereira, E.F.R. Drug Interactions. Secretaria Municipal de Saúde. Rio de Janeiro, Brazil, 1987. 19. Pereira, E.F.R. Factors that Modify the of Orally Administered Drugs: Pharmacokinetic Principles. Associação Brasileira de Farmacêuticos. Rio de Janeiro, RJ, Brazil, 1987.

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