Anti-Pirh 2 Antibody (ARG57882)
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Product datasheet [email protected] ARG57882 Package: 100 μl anti-Pirh 2 antibody Store at: -20°C Summary Product Description Rabbit Polyclonal antibody recognizes Pirh 2 Tested Reactivity Hu, Ms Tested Application WB Host Rabbit Clonality Polyclonal Isotype IgG Target Name Pirh 2 Antigen Species Human Immunogen Recombinant fusion protein corresponding to aa. 1-261 of Human Pirh2 (NP_056251.2). Conjugation Un-conjugated Alternate Names RING finger protein 199; EC 6.3.2.-; RNF199; p53-induced RING-H2 protein; ZNF363; CHIMP; E3 ubiquitin-protein ligase Pirh2; Zinc finger protein 363; ARNIP; ZCHY; CH-rich-interacting match with PLAG1; hPirh2; PRO1996; RING finger and CHY zinc finger domain-containing protein 1; PIRH2; Androgen receptor N-terminal-interacting protein Application Instructions Application table Application Dilution WB 1:200 - 1:1000 Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. Positive Control Mouse pancreas Calculated Mw 30 kDa Observed Size 32 kDa Properties Form Liquid Purification Affinity purified. Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. Preservative 0.02% Sodium azide Stabilizer 50% Glycerol Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. www.arigobio.com 1/2 Note For laboratory research only, not for drug, diagnostic or other use. Bioinformation Gene Symbol RCHY1 Gene Full Name ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase Background The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013] Function Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity. [UniProt] Cellular Localization Nucleus, Nucleus speckle, Cytoplasm. [UniProt] Images ARG57882 anti-Pirh 2 antibody WB image Western blot: 25 µg of Mouse pancreas lysate stained with ARG57882 anti-Pirh 2 antibody at 1:1000 dilution. www.arigobio.com 2/2 Powered by TCPDF (www.tcpdf.org).