Genomic Insights of Body Plan Transitions from Bilateral to Pentameral Symmetry in Echinoderms
ARTICLE https://doi.org/10.1038/s42003-020-1091-1 OPEN Genomic insights of body plan transitions from bilateral to pentameral symmetry in Echinoderms Yongxin Li1, Akihito Omori 2, Rachel L. Flores3, Sheri Satterfield3, Christine Nguyen3, Tatsuya Ota 4, Toko Tsurugaya5, Tetsuro Ikuta6,7, Kazuho Ikeo4, Mani Kikuchi8, Jason C. K. Leong9, Adrian Reich 10, Meng Hao1, Wenting Wan1, Yang Dong 11, Yaondong Ren1, Si Zhang12, Tao Zeng 12, Masahiro Uesaka13, 1234567890():,; Yui Uchida9,14, Xueyan Li 1, Tomoko F. Shibata9, Takahiro Bino15, Kota Ogawa16, Shuji Shigenobu 15, Mariko Kondo 9, Fayou Wang12, Luonan Chen 12,17, Gary Wessel10, Hidetoshi Saiga7,9,18, ✉ ✉ R. Andrew Cameron 19, Brian Livingston3, Cynthia Bradham20, Wen Wang 1,21,22 & Naoki Irie 9,14,22 Echinoderms are an exceptional group of bilaterians that develop pentameral adult symmetry from a bilaterally symmetric larva. However, the genetic basis in evolution and development of this unique transformation remains to be clarified. Here we report newly sequenced genomes, developmental transcriptomes, and proteomes of diverse echinoderms including the green sea urchin (L. variegatus), a sea cucumber (A. japonicus), and with particular emphasis on a sister group of the earliest-diverged echinoderms, the feather star (A. japo- nica). We learned that the last common ancestor of echinoderms retained a well-organized Hox cluster reminiscent of the hemichordate, and had gene sets involved in endoskeleton development. Further, unlike in other animal groups, the most conserved developmental stages were not at the body plan establishing phase, and genes normally involved in bila- terality appear to function in pentameric axis development. These results enhance our understanding of the divergence of protostomes and deuterostomes almost 500 Mya.
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