DOCSLIB.ORG

Review Article

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Review Article Qurba Firdous et al / Int. J. Res. Ayurveda Pharm. 9 (1), 2018 Review Article www.ijrap.net ETHNOPHARMACOLOGY, PHYTOCHEMISTRY AND BIOLOGICAL ACTIVITY OF INULA RACEMOSA HOOK. F: A REVIEW Qurba Firdous 1, Mohammad Faizan Bhat 2, Mubashir Hussain M 3* 1Department of Pharmaceutical Sciences, University of Kashmir, Srinagar, J&K, India 2Research Fellow, Department of Pharmaceutical Sciences, University of Kashmir, Srinagar, J&K, India 3Sr. Assistant Professor, Department of Pharmaceutical Sciences, University of Kashmir, Srinagar, J&K, India Received on: 25/10/17 Accepted on: 18/12/17 *Corresponding author E-mail: [email protected] DOI: 10.7897/2277-4343.09120 ABSTRACT Inula racemosa Hook. F (Asteraceae) commonly known as Pushkaramula is a well documented Indian medicinal plant. Pushkarmula is one of the herbs mentioned in all Ayurvedic scriptures. It possesses various synonyms like kasari- an enemy of cough, sulahara - pain killer, sughandhika - fragrant etc. The great sage Charaka has categorized it as hikkanigrahana – stops hiccup and svasahara – alleviates the breathlessness, asthma. It is also best medicament for pleurisy along with cough and asthma. Pushkarmula is highly acclaimed to be the drug of choice for pleurisy (parsvasula). It has also anti-inflammatory, cardiovascular, hypoglycemic, antianginal, analgesic and antibacterial properties. Many of these ethnomedicinal properties have been experimentally proven in different animal models. This article is an attempt to collect and review all the data concerning systemic scientific study of ethnopharmacology of I. racemosa, its isolated phytoconstituents and bioactivity of extracts as well as isolated compounds from the plant. Keywords: Inula racemosa, ethnopharmacology, phytochemistry, bioactivity. INTRODUCTION Disease3. Various active constituents have been isolated from the plant, most important being sesquiterpene lactones- The plant, Inula racemosa is abundantly found in India, China Alantolactone (ALT), and isoalantolactone (IALT) that show and Europe. The plant grows in temperate and alpine Western anti-inflammatory and decreased proteolytic activity4-5. This Himalayas from 1300 to 4500 meters elevation. The plant is review is therefore aimed to comprehensively collect all the distributed in temperate alpine Himalayas at an altitude of literature regarding ethnopharmacology, phytoconstituents, and 1,500- 4,200m from Kashmir to Kumaon, Afghanistan to biological activity of Inula racemosa. Central Nepal. It occurs wild among strong alpine scrub vegetation in the cold arid habitat of NW Himalayas between Ethnopharmacology 2,700-3,500 m in the eastern Ladakh (Leh) region of Kashmir. Inula racemosa has been used as traditional medicine in East Domesticated forms of this incipient cultigen are cultivated on Asia and Europe. In China it has been prescribed for abdominal borders of agricultural fields of wheat, barley and buckwheat pain, acute enteritis and bacillary dysentery. The roots are both in Kashmir and Lahaul valley of Himachal Pradesh1. The widely used as indigenous medicine, as an expectorant and in plant is a stout shrub, bearing large leaves arranged in a veterinary medicine as a tonic2. Native Americans use this plant racemose manner. The stem is grooved and all vegetative parts for treatment of tuberculosis6. Root powder is reportedly are scabridtomentose. Lower leaves are narrowed to a winged hypoglycemic and hypocholesterolemic in human subjects 7. It leaf stack. Upper leaves are lanceolate and stem clasping. The brought about a beneficial improvement in ST-T changes in abaxiallaminal face is densely tomentose. The fresh root is ECG of patients with Ischemic heart disease (IHD)8. brown and becomes grayish on drying. The fresh roots resemble the aroma of camphor. The fruits, slender achenes have long Combination therapy of Inula racemosa with other plants and pappus hairs. Root stock is branched. Sometimes a number of extracts has also shown substantial biological activities. It is roots are found in the collar zone, though usually few occur in anti-anginal and hypolipidemic when used in combination with each clump. These roots have a dull brownish skin with guggulu in patients with Ischemic heart disease3.It exerts yellowish colour inside. They possess a sweet and somewhat cardioprotective effect in isoproterenol induced myocardial camphoraceous odour and have a bitter taste2. ischemia in rats when used in combination with drugs Terminalia arjuna and Commiphora mukul9.It reduced Inula racemosa is known to be used in traditional medicine corticosteroid induced hyperglycaemia in mice when used with throughout the world, especially East Asia and Europe. Apart Gymnema leaf extract10. from being used for other ailments, the plant extract and its isolated active constituents show promising activity against The drug exhibited negative chronotropic effect and positive abdominal pain, acute enteritis, bacillary dysentery, expectorant ionotropic effect on isolated frog heart with petroleum ether and tonic2. Inula racemosa is also used in combination with extract(200mg/kg).Further, increase of dose to 400mg/kg other plant extracts and used for various conditions including exhibited adrenaline-induced beta blocking activity in rats 11. hyperlipidemia, angina and patients with Ischemic Heart Petroleum ether extract exhibited less hepatoprotective activity 95 Qurba Firdous et al / Int. J. Res. Ayurveda Pharm. 9 (1), 2018 as compared to the aqueous, methanolic and total aqueous from Kashmir is reported to yield 5.7-6.2% petroleum ether extract 12.Moreover, with the alcoholic extract significant extract while those from Lahaul valley, Himachal Pradesh protection against egg albumin induced passive cutaneous reportedly yield 8.5%w/w constituted of 83%lactones1. The anaphylaxis was provided and the alcoholic extract is non-toxic major lactones ALT and IALT are in the ratio 4:6. upto 2100±60mg/kg i.p in rats 13. Furthermore, anti- dermatophytic and anti-cholinergic activities were exhibited by Investigation on the aerial parts of Inula racemosa reported the the crude alcoholic extract, the former reportedly localized in presence of several other sesquiterpene lactones namely ivalin the hexane soluble fraction14. acetate, 2d-OH alantolactone, 1- desoxy-8-epi-ivangustin, 8-epi- isoivangustin, 9β-OH costunolide, 9 β-propionyloxycostunolide, Isolated phytochemical constituents from Inula racemosa 9 β-(2-methylbutaryloxyl) costunolide, 4β-5α-epoxy-10 α, 14H- inuviscolide, 4β, 5α-epoxy-4,5-cis-inunolide, 4H-tomentosin, Inula racemosa yields large amounts of sesquiterpene lactones 4H carbrone. as-Alantolactone (ALT) and isoalantolactone (IALT)4, Dihydroalantolactone, dihydroisoalantolactone, inunolide15, Structure 21 was identified as 1-4-epi-alantolactone;(2) 4- dihydroinunolide, neoalantolactone, isoalloalantolactone16, alpha,13-dihydroxy-5,7(11)-eudesmadien-12,8-olide.Six known alloalantolactone17, inunal, isoinunal18, alantodiene and eudesmane-12,8-olide,viz.,Septuplinolide(3) isoalantodiene19 are other sesquiterpene lactones isolated from 22;macrophyllilactone E (4)23;13-acetyloxy-5,7(11)- the non polar fractions of the root. eudesmadien-12,8-olide (5) 24; 11 alpha,13-dihydro-2alpha- hydroxy-alantolactone (6) 25; 11,13-dihydroivalin (7) 26; Daucosterol, D- mannitol and Beta sitosterol have also been Isoalantolactone(8)27. (Figure 1) reported in good quantities from the roots 20. Roots of ‘mano’ Biological Activities of Isolated Compounds ALT and IALT promotes the growth in number of rootlets of Phaseolus aureus by a factor of 2-2.5 as compared to control in “Sesquiterpene lactones are important because of their various the experiment27. IALT is herbicidal because of its lipophilicity. biological activities and generic inhibition of enzymes28. They It gets incorporated into cell membrane and does not reach to provide protection to the plant against various pathogenic other regions of the plant 31. organisms, insects and mammals. They are secondary metabolites of plant exerting various biochemical effects on ALT and IALT showed an increase in the antioxidant activity of other flora and vertebrate poisoning29. lipids at doses of 100-200 mgkg-1, their action considerably more than antioxidant activity of α-tocopherol and ubiquinone. The main sesquiterpene lactones found in Inula racemosa are The anti-tussive activity of helenin in guinea pigs has been seen, ALT and IALT5.Amixture containing both the lactones is called but it is half that of codeine5, 32. Inula camphor (Helenin). In antiquity Inula helenium (Elecampane) contains both ALT and IALT. It was added to Both ALT and IALT possess antibacterial activities against food as a seasoning in the middle age and later, it came to be many of gram positive and gram negative bacteria. ALT is used for medicinal purposes. Now a days, this mixture is the completely inhibitory to Bacillus subtilis, while IALT exhibited active principle of drug Alanton which is used for ulceration30. weak antibacterial activity towards Bacillus subtilis and Bacillus The drug is anti-inflammatory, antiproteolytic and is used to vulgaris. ALT and helenin possessed pronounced inhibitory regulate the acidic function of the stomach. Alanton also effect against Staphylococcus aureus and Mycobacterium promotes mucin formation and stimulates the regenerative tuberculosis at 31.2-62.5 and 31.22µg/ml respectively. capacity of the gastric mucosa5. The antifungal activity has been studied in relation to more than 16 different cultures for both ALT
Load more

Recommended publications
  • (Compositae-Inuleae) in Pakistan and Kashmir
    Genus Inula L. (s. str.) (Compositae-Inuleae) in Pakistan and Kashmir RUBINA ABID & MOHAMMAD QAISER ABSTRACT ABID, R. & M. QAISER (2002). Genus Inula L. (s. str.) (Compositae-Inuleae) in Pakistan and Kashmir. Candollea 56: 315-325. In English, English and French abstracts. A revision of the genus Inula L. ( s. str .) in Pakistan and Kashmir is presented; eleven species are recognized including Inula stewartii Abid & Qaiser as a species new to science. In addition, key to the related genera and species, distribution, ecological notes and an illustration of the new spe - cies, are also provided. RÉSUMÉ ABID, R. & M. QAISER (2002). Le genre Inula L. (s. str.) (Compositae-Inuleae) au Pakistan et au Cachemire. Candollea 56: 315-325. En anglais, résumés anglais et français. Une révision du genre Inula L. ( s. str. ) est présentée. Onze espèces sont reconnues dont Inula ste - wartii Abid & Qaiser, espèce nouvelle pour la science. Une clé de détermination des genres affines et des espèces reconnues est fournie, ainsi que la distribution, des commentaires écologiques et une illustration de la nouvelle espèce. KEY-WORDS: Inula – COMPOSITAE – Pakistan – Kashmir. Introduction The genus Inula L. ( s. str. ) belongs to the tribe Inuleae of the family Compositae including about 100 species, mainly distributed in Europe, Africa and Asia. The genus Inula was described by LINNAEUS with thirteen species (1753, 1754). The pro - tologue used by LINNAEUS was quite generalized as he did not give the weightage to the finer details of floral characters. Later on, this genus was treated by variuos workers from time to time (viz., CANDOLLE, 1836; BENTHAM & HOOKER, 1873; BOISSIER, 1875; CLARKE, 1876; HOOKER, 1881; BECK, 1882; HOFFMANN, 1890; GORSCHKOVA, 1959; KITAMURA, 1960; GRIERSON, 1975; BALL & TUTIN, 1976; RECHINGER, 1980; ANDERBERG, 1991; KUMAR, 1995).
    [Show full text]
  • The Genus Inula (Asteraceae) in India
    Rheedea Vol. 23(2) 113-127 2013 The genus Inula (Asteraceae) in India Shweta Shekhar, Arun K. Pandey* and Arne A. Anderberg1 Department of Botany, University of Delhi-110007, Delhi, India. 1Department of Botany, Swedish Museum of Natural History P.O. Box 50007, SE-104 05 Stockholm, Sweden *E-mail: [email protected] Abstract A revision of Inula L. in India is provided based on field studies, and examination of herbarium collections. Twelve species of Inula are recognized in India: I. acuminata, I. britannica, I. clarkei, I. falconeri, I. hookeri, I. kalapani, I. macrosperma, I. obtusifolia, I. orientalis, I. racemosa, I. rhizocephala and I. royleana, of which two are endemic, I. kalapani and I. macrosperma. A key to the Indian species, descriptions and illustrations are provided along with data on flowering and fruiting, distribution, habitat, chromosome number, and ethnobotanical uses. Keywords: Inulinae, Taxonomy Introduction The genus Inula L. (Inuleae-Inulinae) includes and of the remaining 8, 6 belong to Duhaldea, 1 to c. 100 species mainly distributed in warm and Dittrichia and 1 to Iphiona (Anderberg, 1991). This temperate regions of Europe, Asia, and Africa paper deals with the critical examination of Inula s. (Anderberg, 2009; Chen & Anderberg, 2011). str. found in India. Anderberg (1991), transferred a number of species to genera like Duhaldea DC., Iphiona Cass. and The genus Inula (s. str.) comprises annual, biennial Dittrichia Greuter. Kumar & Pant (1995) included or perennial herbs. In India, the genus is distributed 20 species in their treatment of Inula in India. in Trans Himalaya, Western Himalaya and the According to Karthikeyan et al.
    [Show full text]
  • Review on Phytochemical and Phytotherapeutic Properties of Inula
    IJRDO - Journal of Applied Science ISSN: 2455-6653 Review on Phytochemical and phytotherapeutic properties of Inula racemosa Ajit Kumar Marisetti* and Venkatarathanamma V Department of Zoology, Acharya Nagarjuna University, Nagarjunanagar, Andhra Pradesh, India ABSTRACT From ancient times various diseases have treated by using medicinal plants and phyogenic products throughout the world. Crude extracts are now considered a valuble source for natural products used in the development of medicines against various diseases for the development of pharmaceutical preparations and for novel biomedical research. Inula racemosa mostly distributed in Asia in hilly areas. These plants are used for traditional medicine for several years for various diseases. These plants have been used in treating different diseases like gastric irritability, febrifuge, nervous depression, anthelmintic, liver complients, jaundice, sores in eyes and fever etc. The present review aims to present a brief overview of the medicinal use as well pharmacological value of the plants focusing for the current research work on Lung cancer. Keywords: Inula racemosa, Taxonomical classification, Phytochemical constituents and Phytotherapeutic effects. INTRODUCTION Worldwide traditional medicine are used based on the availability of plant species, plant based products, economic affordability and effective against certain diseases when compared to modern medicine. Traditional medicinal plants knowledge has been accumulated in course of many centuries based on various medicanal systems like Ayurveda, unani, homeopathy and siddha. Traditional knowledge about plants is important in herbal medicine as well as in pharmaceutical industry, since they provide the raw materials and other prerequisite information about plant based drugs [1]. Inula racemosa is known by different names around the world including the Indian sub-continent.
    [Show full text]
  • Pharmacognosy Ofiphiona Grantioides (Boiss.) Anderb
    PHARMACOGNOSY OFIPHIONA GRANTIOIDES (BOISS.) ANDERB. AND PLUCHEA ARGUTA BOISS. SUBSP. GLABRA QAISER OF FAMILY ASTERACEAE Ph. D. THESIS BY SHAHIDA NAVEED DEPARTMENT OF BOTANY UNIVERSITY OF PESHAWAR May 2014 PHARMACOGNOSY OFIPHIONA GRANTIOIDES (BOISS.) ANDERB. AND PLUCHEA ARGUTA BOISS. SUBSP. GLABRA QAISER OF FAMILY ASTERACEAE. SHAHIDA NAVEED A THESIS SUBMITTED TO THE DEPARTMENT OF BOTANY, UNIVERSITY OF PESHAWAR, PESHAWAR, PAKISTAN IN PARTIAL FULFILLMENT FOR THE REQUIREMENT OF DEGREE OF DOCTOR OF PHILOSOPHY IN BOTANY DEPARTMENT OF BOTANY UNIVERSITY OF PESHAWAR May 2014 DECLARATION The materials contained within this thesis are my original work and have not been submitted before to this or to any other university. Shahida Naveed CERTIFICATE OF APPROVAL This Dissertation, entitled ―PHARMACOGNOSY OFIPHIONA GRANTIOIDES (BOISS.) ANDERB. AND PLUCHEA ARGUTA BOISS. SUBSP. GLABRA QAISER OF FAMILY ASTERACEAE ‖ submitted by Shahida Naveed is hereby approved and recommended as partial fulfillment for the award of Degree of Doctor of Philosophy in Botany. Professor Dr. Muhammad Ibrar ______________________ Research Supervisor, Department of Botany, University of Peshawar. External _______________________ Examiner Professor Dr. Muhammad Ibrar ________________________ Chairman, Department of Botany, University of Peshawar. DEPARTMENT OF BOTANY UNIVERSITY OF PESHAWAR May 2014 DEDICATED TO MY PARENTS MY HUSBAND AND MY KIDS AHSAN ZUNAIRA MOHSIN LIST OF CONTENTS S .No CONTENTS P. NO Acknowledgement i Abstract iii Publications x CHAPTER-1 INTRODUCTION 1-27 1.1 Pharmacognosy 1 1.2 Medicinal plants 2 1.3 Phytosociology 4 1.4 Ethnobotany 5 1.5 Pharmacognostic study 5 1.5.1 Identification and authentification of plant material 7 1.5.2 Anatomy/Histology 7 1.5.3 Phytochemical analysis 7 1.5.4 Extractive value 8 1.5.5 Fluorescence study 8 1.5.6.
    [Show full text]
  • A Review on the Micropropogation of an Important Medicinal Plant Inula Racemosa Hook
    Available online at http://www.journalijdr.com ISSN: 2230-9926 International Journal of Development Research Vol. 07, Issue, 10, pp.16369-16372, October, 2017 ORIGINAL RESEARCH ARTICLEORIGINAL RESEARCH ARTICLE OPEN ACCESS A REVIEW ON THE MICROPROPOGATION OF AN IMPORTANT MEDICINAL PLANT INULA RACEMOSA HOOK. F. 1Prachi Sharma, 1Anamika Malav and ,*2Prahlad dube 1Career Point University, Kota (Rajasthan) 2HOD, Department of Life science, University of Kota, Kota (Rajasthan) ARTICLE INFO ABSTRACT Article History: Medicinal plants have been used indigenously since ancient past as medicines for the treatment of Received 29th July, 2017 various ailments. Medicinal plants based traditional systems of medicines are playing important Received in revised form role in providing health care to large section of population, especially in developing countries. 04th August, 2017 th The global demand for herbal medicine is not only large, but growing. Due to many reasons many Accepted 17 September, 2017 plants are becoming endanger or about to extinct. Most of the causal factors currently threatening Published online 30th October, 2017 plant species are anthropogenic in nature i.e. induced or influenced by man. These factors include habitat loss or modification often associated with habitat fragmentation, over-exploitation for Keywords: commercial and subsistence reasons, accidental or deliberate introduction of exotic species which Plant tissue culture, may compete with native species. Inula racemosa Hook. F. is one such plant which is listed as a Micropropogation, rare species according to the Red Data Book of Indian plants. Due to the fragile nature of its Inula racemosa, habitat and exploitation because of its commercial medicinal properties, the species are facing the Medicinal plants, onslaught of indiscriminate over-exploitation while other reasons include lengthy cultivation MS medium.
    [Show full text]
  • 10Th CMAPSEEC: BOOK of ABSTRACTS
    10th CMAPSEEC: BOOK OF ABSTRACTS 10th Conference on Medicinal and Aromatic Plants of Southeast European Countries May 20-24, 2018, Split, Croatia 10th CMAPSEEC 10th Conference on Medicinal and Aromatic Plants of Southeast European Countries May 20-24, 2018, Split, Croatia Jointly organized by: Association for Medicinal and Aromatic Plants of Southeast European Countries (AMAPSEEC), Belgrade, Serbia and University of Zagreb, Faculty of Agriculture, Zagreb, Croatia Institute for Adriatic Crops and Karst Reclamation, Split, Croatia Centre of Excellence for Biodiversity and Molecular Plant Breeding (CroP-BioDiv), Zagreb, Croatia Under the patronage of: Ministry of Agriculture of the Republic of Croatia, Zagreb, Croatia Ministry of Science of the Republic of Croatia, Zagreb, Croatia Academy of Agricultural Sciencies, Zagreb, Croatia Editors Klaudija Carović-Stanko <[email protected]> University of Zagreb, Faculty of Agriculture, Zagreb, Croatia Centre of Excellence for Biodiversity and Molecular Plant Breeding (CroP-BioDiv), Zagreb, Croatia Martina Grdiša <[email protected]> University of Zagreb, Faculty of Agriculture, Zagreb, Croatia Centre of Excellence for Biodiversity and Molecular Plant Breeding (CroP-BioDiv), Zagreb, Croatia Technical Editor Filip Varga <[email protected]> University of Zagreb, Faculty of Agriculture, Zagreb, Croatia Centre of Excellence for Biodiversity and Molecular Plant Breeding (CroP-BioDiv), Zagreb, Croatia ISBN: 978-953-7878-82-5 Printed by: Novi Val d.o.o. Web: www.cmapseec2018.com Citation: Carović-Stanko, K., Grdiša,
    [Show full text]
  • Chemistry and Biological Activity of Some
    Pharmacophore 2014, Vol. 5 (4), 536-551 USA CODEN: PHARM7 ISSN 2229-5402 Pharmacophore (An International Research Journal) Available online at http://www.pharmacophorejournal.com/ Review Article CHEMISTRY AND BIOLOGICAL ACTIVITY OF SOME ALANTOLOIDS FROM INULA SPECIES - A REVIEW Ramandeep Kaur, Dalvir Kataria and K K Chahal* Department of Chemistry, Punjab Agricultural University, Ludhiana, Punjab-141004, India ABSTRACT The compounds present in plants of genus Inula exhibit wide spectrum of biological and medicinal activities. These plants are rich source of wide variety of bioactive secondary metabolites such as tannins, terpenoids, alkaloids, and flavonoids. Alantolactone and Isoalantolactone are the major compounds present in Inula plants. The selection of the plants in the present study is primarily based on their chemistry, biological and medicinal properties reported. This review attempts to summarize the current status of reported various activities of Inula species. Some very interesting findings have been observed and thus recorded and reported in this review. Keywords: Inula, Sesquiterpenoids, Secondary metabolites, Alantolactone, Isoalantolactone. INTRODUCTION Natural product chemistry has always been one of the most aspiring fields of chemistry. Among the natural products, sesquiterpene lactones having α-methylene-γ-lactone moiety are studied the most for their chemistry, mechanistic pathway, their chemical transformations and synthesis because of their bioactive nature. Sesquiterpenoids, marvellously varied group of compounds
    [Show full text]
  • MEDICINAL VALUE of INULA RACEMES HOOK. F. (PUSHKARMOOLA) Sharma Ashwini Kumar*
    Ashwini Sharma. UJAHM 2014, 02 (02): Page 11-13 ISSN 2347 -2375 UNIQUE JOURNAL OF AYURVEDIC AND HERBAL MEDICINES Available online: www.ujconline.net Review Article MEDICINAL VALUE OF INULA RACEMES HOOK. F. (PUSHKARMOOLA) Sharma Ashwini Kumar* Lecturer,P.G. Department of Drvya Guna Rishikul govt.p.g.ayurvdic college and hospital,Haridwar Received 20-01-2014; Revised 18-02-2014; Accepted 17-03-2014 *Corresponding Author : Dr. Ashwini kumar Sharma Lecturer, P.G. Department of Drvya Guna Rishikul Govt.p.g.ayurvdic college and hospital, Haridwar Email- [email protected] cell no.-8449910094 ABSTRACT Inula racemosa hook.f. is herb (plant) is used in traditional medicine in India for a long time .it is used in drugs by pharma industries for its antispasmodic,anti asthmatic and cardic tonic properties. This is a member of Asteraceae family. It is commonly known as Puskaramula in Sanskrit and Pokharmula hindi. It is a tall ,stout herb found in western Himalayas between 5000 to 14000 ft altitude. The great ayurved physician charaka has indicated it “PUSKARMULAM HIKKA KASA SWAS PARSWASULA HARANAM” 1 means this is the best drug of Hikka(Hiccups), Swas (Asthma), Parswa sula (both side chest pain ). But now these days iris Germania ,Inula royeliana ,Hedichyum spicatum are using instead of Inula racemosa by the pharma industries and ayurveda physicians during their clinical practice. Keywords: Inula racemosa, Pokharmula, Hikka, Parswasula, Iris germanica, Inula royelina, Hedichyum spicatum. During review of literature it’s noticed that Puskarmula is not INTRODUCTION used for skin diseases whereas Saussurea lappa is extermly The Indian system of traditional medicine is a part of a time used for various skin diseases.
    [Show full text]
  • Inula Racemosa
    The Pharma Innovation Journal 2018; 7(6): 27-32 ISSN (E): 2277- 7695 ISSN (P): 2349-8242 NAAS Rating: 5.03 Inula racemosa: An Insight into Callus Induction, TPI 2018; 7(6): 27-32 © 2018 TPI Secondary Metabolites and its Therapeutic Potential www.thepharmajournal.com Received: 02-04-2018 Accepted: 04-05-2018 Shelly Kapoor Shelly Kapoor Department of Biotechnology Abstract Dr. Y S Parmar University of Inula racemosa (Hook.f), commonly referred to by the name Pushkarmula, is an important medicinal and Horticulture and Forestry, ornamental plant of Asteraceae family and has numerous references in Ayurvedic scriptures. The plant is Nauni, Solan (HP), India inhabited to the Western Himalayas and grows at an altitude ranging from 1300 to 4500 meters. The plant is a perennial, paraphyletic, stout herb with elliptical, large leaves and yellow flowers. Extracts made from different plant parts are used to treat a number of diseases in the form of oil, ointment, syrup, powder, tablet etc. either by consumption or application. Traditionally, its roots have antiseptic, anti- bacterial, anti-fungal, anti-inflammatory and analgesic properties. Because of these properties it is used in the treatment of contagious fevers, heart diseases, indigestion and other diseases related to respiratory tract. Due to over exploitation and reckless collection of the species by pharmaceutical companies, it has become critically endangered in its own habitat. To conserve the germplasm of this therapeutically important species from extinction, in vitro propagation strategies are required. The major constraint in micropropagation strategies is the long waiting period ranging from six to eight months. To overcome this problem, propagation of numerous calli from leaves can be obtained in just 2-3 weeks.
    [Show full text]
  • A Review on the Anti-Cancerous Activity of an Important Medicinal Plant Inula Racemosa Hook
    A review on the anti-cancerous activity of an important medicinal plant Inula racemosa Hook. F. Prachi Sharma1 , Prahlad Dube2 1 Career Point University, Kota (Rajasthan) 2HOD, Department of Life science, University of Kota, Kota (Rajasthan) ABSTRACT The word” Cancer” is an umbrella term with a group of approximately 200 diseases. Cancer has emerged as a major problem globally. It is the second largest health problem of the world after cardiovascular diseases both in developed and in developing countries. At present, there is no specific treatment for the cure of cancer as allopathic medicines provide only short time relief from symptoms or severity. Radiotherapy or chemotherapy also gives a way for temporary relief but at the cost of severe side effects. Surgical interventions, chemo and radio therapies have failed consistently to cure many varieties of cancers. This hopeless situation demands for newer kind of therapeutic interventions which may not be the conventional modes of therapy. Scientific research interest is drawing its attention towards naturally-derived compounds as they are considered to have less toxic side effects. Inula racemose Hook. F. has proved to be a great success for the treatment of this deadly disease. The plant has several anti cancerous properties which make it very effective in the treatment of all types of cancer. The review discusses the important role of I. racemose in the treatment of cancer and it types. Keywords: Cancer, Radiotherapy, Chemotherapy, Anti-cancerous, Inula racemosa I. INTRODUCTION Cancer is a major burden of disease worldwide. Each year, tens of millions of people are diagnosed with cancer around the world, and more than half of the patients eventually die from it.
    [Show full text]
  • Research Article
    Nagar Lalit et al / Int. J. Res. Ayurveda Pharm. 8 (5), 2017 Research Article www.ijrap.net 50% H2SO4 TEST: A SIMPLE TEST TO DIFFERENTIATE BETWEEN PUSHKARMOOL (Inula racemosa Hook.f.) AND KUSTHA (Saussurea lappa C. B. Clarke) Nagar Lalit *1, Lamo Ringzin 2, Rath Sudipt Kumar 3 1PhD Scholar, Department of Dravyaguna, Faculty of Ayurveda, IMS, BHU, Varanasi, India 2Assistant Professor, Department of Agadtantra, Faculty of Ayurveda, IMS, BHU, Varanasi, India 3Assistant Professor, Department of Dravyaguna, NIA, Jaipur, India Received on: 12/08/17 Accepted on: 23/09/17 *Corresponding author E-mail: [email protected] DOI: 10.7897/2277-4343.085241 ABSTRACT Himalaya is the source of many valuable herbs like Pushkarmoola (Inula racemosa), kustha (Saussurea lappa), katuki (Picrorhiza kurroa), Ativisha (Aconitum heterophyllum), Chirayata (Swertia chirata), Vatsanabha (Aconitum ferox) etc. These herbs are present in the limited pocket which leads to the scarcity of Himalayan herbs. But due to the globalization, demand is increasing and production is decreasing. This decrea se in production gives chance to the raw drug traders to adopt unscrupulous trade. There is a vast document available with regard to morphology of green drugs; it is not of much relevance for physicians who are totally dependent on market for the procurement of medicinal plant raw materials. Many raw materials, in dry form shows common features thus creating lot of confusion and controversy in identification of the crude drug. Same is the case with Pushkarmool (Inula racemosa) and Kustha (Saussurea lappa) both of these herbs are difficult to differentiate from each other. In this test a small amount of powdered Pushkarmool (Inula racemosa) and Kustha (Saussurea lappa) treated with solution of 50% sulphuric acid.
    [Show full text]
  • Taylor and Francis Taylor and Francis Medicinal Plants in Asia for Metabolic Syndrome Natural Products and Molecular Basis
    Medicinal Plants in Asia for Metabolic Syndrome Taylor and Francis Taylor and Francis Medicinal Plants in Asia for Metabolic Syndrome Natural Products and Molecular Basis Christophe Wiart Taylor and Francis CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2018 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Printed on acid-free paper International Standard Book Number-13: 978-1-1380-3759-5 (Hardback) This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint. Taylor and Francis Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, micro- filming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www.copyright.com (http://www.
    [Show full text]