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0 UPMC Cancer Centers and University of Pittsburgh Cancer Institute 0 2 l l a f

EXPORTING STATE-OF-THE-ART CARE I R L CONTENTS

IRELAND UPMC Cancer Centers and Exporting state-of-the-art care University of Pittsburgh Cancer Institute 2

TARGETING BETTER TREATMENT 4 New technologies enhancing radiation therapy outcomes

COMBATING THE KILLER TAN Nearly 1 million Americans will be diagnosed with skin cancer this year 6

“WHY ME?” 10 New program gaining insight into the causes of cancer

Editor ...... Betsy Martinelli VOLUNTEERS Contributors ...... Clare Collins Improving quality of life for patients and their families ...... Carey Anne Zucca 14 Graphic Design ...... Larry Hruska THE POWER OF PARTNERSHIP ...... Chris Konopack 18 NEWS BRIEFS 26 cDISa COnVERYc&eCAr RE Cancer Discovery & Care is a publication of the University of Pittsburgh Cancer Institute (UPCI) and UPMC Cancer Centers and is produced by UPMC Corporate Communications. All rights reserved. No portion of this magazine may be reproduced without written permission. Send suggestions, comments, or address changes to Betsy Martinelli at UPCI/ UPMC Cancer Centers, Office of Communications, UPMC Cancer Pavilion, 5150 Centre Ave., Room 457c, Pittsburgh, PA 15232, or via e-mail at [email protected]. UPMC CANCER CENTERS EXECUTIVE LEADERSHIP UNIVERSITY OF PITTSBURGH CANCER INSTITUTE EXECUTIVE LEADERSHIP Ronald B. Herberman, MD – Director Ronald B. Herberman, MD – Director MAKING PREVENTION A PRIORITY Stanley M. Marks, MD – Director of Clinical Hillman Professor of Oncology Services and Chief Medical Officer Associate Vice Chancellor, Cancer Research With the skyrocketing costs related to the treatment of cancer, it is logical that sig - Jeffrey E. Shogan, MD – Director of Business Andrew S. Baum, PhD – Director of Behavioral nificant emphasis should be placed on research and development efforts to prevent Services and Chief Business Officer Sciences and Cancer Control this devastating disease. Indeed, strategic prevention initiatives have the potential for the greatest impact on the societal and economic burden of cancer. Fortunately, Charles E. Bogosta, MBA – Executive Vice President, Michael J. Becich, MD, PhD – Associate Director for Cancer Informatics Cancer Services there has been a rapid increase in our understanding of the interactions at the Charles E. Bogosta, MBA – Associate Director for Finance molecular level between genetic factors and the environment that lead to the development and progression of David L. Bartlett, MD – Co-Director of Surgical Oncology cancer, and these insights are providing important opportunities for targeted interventions to prevent cancer. But Services and Chief, Division of Surgical Oncology Preet M. Chaudhary, MD – Director of Translational Research how do we identify and prioritize these potential initiatives, and more importantly, how can we successfully imple - and Co-Leader, Hematologic Malignancies Program ment them? Brian Clark, MD – Director of Cancer Genetic Services Clare Collins, MA, MEd – Assistant Director for Media Relations Strategic prevention initiatives These important questions were the focus of a national summit on cancer prevention Dwight E. Heron, MD – Director of Radiation Oncology Services research that I had the honor to organize and chair, on behalf of C-Change. C-Change is Maryann Donovan, PhD, MPH – Associate Director have the potential for the a national coalition of leaders from the government, business, and nonprofit sectors dedi - Holly Lorenz, RN, MSN – Vice President and for Research Services and Advancement cated to eliminating cancer as a major public health problem. Under the leadership of greatest impact on the societal Chief Operating Officer for Clinical Services former President George H. W. Bush, former First Lady Barbara Bush, and Senator Diane Kenneth A. Foon, MD – Director of Clinical Investigations Feinstein, C-Change members have a shared vision of a future “where cancer is prevented, James D. Luketich, MD – Co-Director of Surgical Oncology Services and economic burden of cancer. and Director and Chief, Heart, Lung, and Esophageal Surgical Institute Vijaya C. Gandhi, PhD, MBA – Associate Director for detected early, and cured or managed successfully as a chronic illness.” Administration and Strategic Planning The national C-Change Summit has led to a plan for developing specific, feasible actions to: Colleen McCabe Mantini, MPA – Director of Government Relations Michael T. Lotze, MD – Associate Director for Strategic Partnerships • substantially increase investment by the federal government and the pharmaceutical, biotech, and food indus - Betsy S. Martinelli – Manager of Communications tries in discovery and development of cancer preventatives, both protective drugs and vaccines Colleen McCabe Mantini, MPA – Director of Governmental Relations Jennifer M. Raetz – Development Director • change policies, procedures, and laws to encourage investment by industry Shivendra V. Singh, PhD – Director of Basic Research Beth Wild Shiring, MBA – Vice President and • modify the regulatory burden on the Food and Drug Administration for balanced consideration of the bene - Chief Operating Officer for Business Services Emanuela Taioli, MD, PhD – Director of Cancer Prevention fits as well as risks of preventive agents and Population Sciences • modify policies of the Centers for Medicare and Medicaid Services and private payers for coverage for effec - Jennifer M. Raetz – Development Director tive cancer preventive agents

• educate the public and health care providers on important benefits of cancer prevention

At UPMC Cancer Centers and the University of Pittsburgh Cancer Institute (UPCI), we are setting a national Sy Holzer, Chair Kent G. George UPCI COUNCIL Jeffrey Lipton Cynthia Roth example in the implementation of strategies that begin to address many of these goals. We are educating state and Elsie H. Hillman, Vice Chair Edwin H. Gott Jr. David Malone Susan C. Santa-Cruz federal officials about the need for more resources, through tours of our community cancer centers as well as the Curtis Aiken Thomas B. Grealish Kevin McClatchy Frederic B. Sargent Hillman Cancer Center. We are implementing research programs to track lifestyle patterns and study the impact Thomas Balestrieri Roy W. Haley Leslie McCombs Steve Schwarzwaelder of those patterns on the prevention of cancer. And we are developing the prevention tools, in the form of cancer G. Nicholas Beckwith III Robert W. Hannan Martin G. McGuinn Dan Shapira vaccines and natural chemicals in foods, coupled with very promising laboratory tests of blood for early detection James Broadhurst I. N. Rendall Harper Jr. Katie McSorley Robert Slagle of cancer, that one day will lead to a future without cancer. Harriet Crawford The Honorable Melissa A. Hart Bob Meyer Lorene Steffes Barbara Crown Mark Hart Thomas H. Nimick Jr. Arthur H. Stroyd Joseph W. DeNardo Sakiko Ishii Eugene J. O’Sullivan Janet B. Taber (honorary member) Robert C. Denove Bill Isler Arnold Palmer Thomas VanKirk Douglas P. Dick William Kassling Brian Patten The Honorable Jack Wagner George A. Fechter Mario Lemieux The Honorable John E. Peterson William Watts Lee B. Foster Sally Levin The Honorable John R. Pippy The Honorable John Weinstein Chip Ganassi Edward J. Lewis Jane Roesch Ronald B. Herberman, MD

IN MEMORIAM Hillman Professor of Oncology Director, UPMC Cancer Centers and the WILLIAM M. COOPER, MD, JD, MACP: On Sept. 12, 2006, UPMC Cancer Centers and the University of Pittsburgh Cancer Institute lost a good University of Pittsburgh Cancer Institute friend and advocate. Dr. Cooper, an oncologist, UPCI Council member, and former chair of the UPMC Shadyside Department of Medicine , made a life - long commitment to raising the standards for compassionate patient care as well as educating physicians about this most important component of medicine.

University of Pittsburgh Cancer Institute 1 I R L

EXPORTING STATE-OF-THE-ART CARE by Betsy Martinelli

Travelers driving into the City of Waterford follow a beautiful coastal road – Waterford, located in the Southeast region of Ireland, is “The dire need for radiotherapy in Waterford has been well-documented,” more than 100 miles from the nearest radiation oncology explains Charles E. Bogosta, executive vice president for Strategic Port Lairge on one side and a towering green hillside on the other. In the distance centers in Dublin and Cork. Patients Business Initiatives and Cancer Services, UPMC. undergoing radiation therapy travel up to “It presented a perfect opportunity to export the “a perfect opportunity is a billowing white banner. six hours round-trip daily to receive treat - cancer technology, expertise, and treatment “WE NEED RADIOTHERAPY NOW.” ment. To address this burden, patients and to export the cancer delivery that we’ve successfully developed, refined, health advocates are desperately seeking technology, expertise, and implemented here in western Pennsylvania to It’s a striking message against this otherwise serene vista. new alternatives for treatment more con - and treatment delivery an international site.” venient to Waterford. that we’ve successfully UPMC Whitfield Cancer Centre is a joint pro - ENTER UPMC CANCER CENTERS. developed, refined, and gram with Euro Care International, an Irish health Following the successful hub-and-satellite model implemented” care infrastructure development company. The established in western Pennsylvania, UPMC cancer center is housed in Whitfield Clinic, a 65- — Charles E. Bogosta Cancer Centers is making its first foray into inter - bed hospital facility offering elective surgery, national care with the opening of UPMC diagnostic testing, and physiotherapy, owned and Whitfield Cancer Centre. The University of Pittsburgh Medical operated by Euro Care International. Center (UPMC) has proven expertise in management and delivery of UPMC Whitfield Cancer Centre will offer state-of-the-art radiation care to patients worldwide. This new radiation oncology facility now oncology and imaging services, including intensity-modulated radia - brings state-of-the-art cancer treatment to patients in Waterford. tion therapy (IMRT) and its newest form, image-guided radiation therapy (IGRT), as well as PET/CT imaging.

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2 UPMC Cancer Centers University of Pittsburgh Cancer Institute 3 I R L

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IMRT uses three-dimensional images obtained through PET/CT to more precisely target radiation beams directly to a tumor, sparing the surrounding healthy, noncancerous tissue, and resulting in fewer treatment- related side effects for the patient. The precise nature of the treatment TARGETING requires a highly trained medical physicist and sophisticated equipment — making the treatment cost-prohibitive for many cancer centers. However, BETTER TREATMENT through the telemedicine network already established here in western Pennsylvania, UPMC is able to New Technologies Enhancing Radiation Therapy Outcomes extend this expertise to Waterford.

“Through UPMC Cancer In the more than 100 years since radiation was first used as a treatment for Centers’ telemedicine network, cancer, scientists have worked to better understand its biological effects. With the expertise and treatment planning needed for IMRT are advancements in technology resulting in more sophisticated equipment, available centrally at the Pittsburgh hub,” explains Jeffrey oncologists are now able to aim the radiation beam more precisely to target Shogan, MD, director for tumors, resulting in better outcomes for cancer patients. “Information is easily Clinical Business and Practice shared by the two sites Operations, UPMC Cancer through the use of a Centers. “Information is easily shared by the two sites through telecommunications system, the use of a telecommunications t UPMC Cancer Centers, are seeing dramatic effects for The Trilogy system features an Timing Treatment By using the OBI to generate The Trilogy system is currently ensuring that the patient in a multi-disciplinary our patients,” explains Dwight On-Board Imager (OBI), a CT-like high-quality, real-time x-ray housed in the Mary Hillman system, ensuring that the patient Dr. Heron and his clinical team team of radiation Heron, MD, director of radia - scanner that is used to take images of the targeted area Jennings Radiation Oncology Waterford receives the same in Waterford receives the same A are now using this sophisticated oncologists, medical physi - tion oncology services at images of the cancerous areas immediately before each treat - Center located at UPMC state-of-the-art care.” state-of-the-art care available in technology to treat lung cancer — cists, pathologists, surgeons, UPMC Cancer Centers. to better track tumor move - ment, the team is able to ensure Shadyside — the hub for the United States.” one of the most difficult cancers — Jeffrey Shogan, MD and other cancer care special - ment. This allows the radiation that only the cancerous area is radiation oncology services at to treat with radiation. Since IGRT, the next phase of IMRT, ists is using advanced Minimizing Patient Risk oncologist to make adjustments being radiated. Zeroing in on the UPMC Cancer Centers. A second lung tumors often move with also will be available at the diagnostics, innovative during the treatment to ensure tumor while adapting for machine with OBI is located at UPMC Cancer Centers is one breathing, accurate targeting of Waterford location. IGRT helps the radiation oncologist to deliver radia - treatment modalities, and that the radiation is focused on breathing motion reduces the UPMC Passavant, offering easier of the first in western the radiation beam is difficult to tion therapy more precisely to a tumor by tracking movement. As the tumor cutting-edge technology to the cancerous areas. risk of complications and mini - access to this advanced Pennsylvania to employ the achieve without treating large moves due to normal breathing patterns, adjustments are made to allow for continually refine comprehen - mizes side effects for the patient. technology to patients in the Trilogy system, an advanced “Before we had technologies like volumes of normal tissues. that movement, making the delivery of the radiation even more exact. sive treatment strategies that northern suburbs of Pittsburgh. linear accelerator — the the Trilogy machine, radiation “To have all of these capabilities are tailored to each individual “The treatment plan must be UPMC Whitfield Cancer Centre will begin treating patients in mid- machine used to deliver radia - delivery was like uniform fully integrated with the treat - patient’s situation. carefully designed to protect November 2006. UPMC Cancer Centers is also exploring expanded tion to a tumor. With Trilogy, streams of water pouring from a ment machine has given us the the healthy tissue and organs ventures in Ireland, including a new radiation therapy center in Dublin, “With advanced medical radiation oncologists are able showerhead,” Dr. Heron explains. power to truly tailor cancer treat - around the tumor — in the case as well as in the United Kingdom and Italy. physics and treatment to treat tumors in difficult to “Now we are able to lessen, or ment for each and every patient, of lung cancer, the heart and planning, combined with reach areas with minimal risks altogether stop, some streams of which should result in not only the esophagus. We also are equipment that allows us to compared to conventional sur - radiation that could affect better quality of life, but better concerned about compromising track the movement of tumors gical or radiation approaches. healthy tissue located around outcomes,” says Dr. Heron. the patient’s ability to breathe,” at the time of treatment, we the tumor. This allows us to make Dr. Heron explains. individual adjustments based on what we’re seeing that day.”

4 UPMC Cancer Centers University of Pittsburgh Cancer Institute 5 What is skin cancer?

he many types of skin cancer are divided into two categories: non-melanoma and melanoma. TBasal cell and squamous cell are common types of non-melanoma, which are less aggressive and have higher survival rates. Of these common cancers, malignant melanoma is the most life-threatening and occurs when cancer cells arise from the melanocyte cells of the skin. Melanocytes make melanin, which gives skin its natural pigment and is found in the epidermis, or outer layer of the skin. As skin is exposed to the sun, these cells produce more pigment, resulting in a tan.

Over the past two decades, the incidence of melanoma has doubled in the United States. “About 55,000 people develop melanoma each year, and it’s the leading cause of death in women ages 25 to 35,” says John Kirkwood, MD, professor of medicine and dermatology; vice chairman for clinical research, Department of Medicine, UPMC; and director of the internationally renowned by Carey Anne Zucca University of Pittsburgh Cancer Institute Melanoma and Skin Cancer Program. “The Melanoma and Skin Cancer Program was founded by Dr. Kirkwood more than 20 years ago,” says Ronald Herberman, MD, director, UPMC Cancer Centers and University of Pittsburgh Cancer Institute, adding, “It was one of the first to be started at UPCI.”

Cutting-edge detection and treatment

UPCI and UPMC Cancer Centers offer a variety of new and innovative detection and treatment options for patients worldwide. “Most skin cancers can be treated effectively if detected early,” explains Louis D. Falo Jr., MD, PhD, professor and chairman of the Department of Dermatology, UPMC. To enable early detection, UPMC physicians offer comprehensive skin examinations including dermoscopic evaluation and systematic whole body imaging services. For those diagnosed with melanoma, treatments include surgery to remove tumors or extract melanoma and surrounding tissue; sentinel node mapping, which provides a “tracking system” for melanoma that has spread Nearly one million Americans will be to the region of the lymph nodes; and wide local excision with or without the removal of additional lymph nodes (lymphadenectomy). Skin grafting and newer plastic surgery procedures provide diagnosed with skin cancer this year. easier recovery for the patient with less scarring. If the risk of relapse is predicted to be elevated, some patients may undergo immunologic treatments.

It is 2006, and the expression “killer tan” has taken on a new meaning. A true advocate of clinical trials The days of using baby oil to achieve the ultimate tan have passed, and the UPMC is already known for its world-class melanoma center, thanks to cutting-edge research. urban myth that a visit to the tanning bed will lessen the chances of Dr. Kirkwood is an advocate of clinical trials and is actively involved in several, including the largest peptide vaccine clinical trial in the country. “We pioneered the first FDA-approved melanoma therapy getting cancer due to reduced exposure time has been debunked. Scientists for the prevention of relapse, which has been a major step forward in treating skin cancer,” says Dr. Kirkwood, highlighting a study published in the July 2006 issue of the Journal of Clinical Oncology . at the University of Pittsburgh Cancer Institute (UPCI) and UPMC Cancer Centers The study finds that when a high dose of the protein interferon (HDI) is administered prior to treat - ment, it is highly effective for the treatment of patients with high-risk, stage III melanoma, improving are collaborating on several promising new research projects in an effort to overall survival rates and in some cases, rendering patients disease-free. Twenty patients with palpable, bump skin cancer out of its spot as the number one cancer in the country. regional lymph node metastatic melanoma were enrolled in the clinical trial between January 2001 and February 2005. At a median follow up of 18 months, half of the participants showed no evidence of recurrent disease. “This is the first reported evaluation of HDI given as a single-agent neoadjuvant therapy for treatment of melanoma,” says Dr. Kirkwood, “and we are very excited about the results as well as the future for this type of treatment.” >>

6 UPMC Cancer Centers University of Pittsburgh Cancer Institute 7 >> Combating the Killer Tan

When melanoma spreads beyond the possibility of surgical Get to Know Your Skin treatment, professionals at UPMC Cancer Centers and UPCI turn to immunotherapy. Most recently, Drs. Kirkwood and Falo tested The best option for combating cancer is early detection. In addition to When Mark Hoover was in his mid-twenties he decided to be mole a type of immunotherapy in which dendritic cells are activated to performing regular breast or testicular self-examinations, it is important mapped. As a lifeguard throughout his adolescence, he was concerned combat cancer by exposing them to fragments of viruses and bacteria to get to know your skin. High-risk melanoma patients, including about how “moley” — to use Mark’s term — he had become. He to mimic danger. Because they exist in the skin, dendritic cells are people with a family history of the disease, may employ the help of contacted the Cutaneous Oncology and Photopheresis Center and usually the first to recognize the presence of a foreign body, or a “mole map” by visiting Larisa J. Geskin, MD, FAAD, assistant was enrolled as a patient of Dr. Geskin’s. Mr. Hoover admits, “It antigen. Although dendritic cells – often dubbed the “pacemakers” professor of dermatology, and director of the Cutaneous Oncology was a bit uncomfortable at first to have every quadrant of my body of the immune system – play a vital role in the initiation of immune and Photopheresis Center. photographed, but when I returned for a follow-up visit, it was so responses, cancer cells often elude them. easy for Dr. Geskin to examine me using the digital photos for a skin Mole mapping or body mapping involves taking digital photographs comparison.” During one of these visits, several moles were removed of the entire body. Specially trained medical photographers use digital for biopsy, and melanoma was cameras in a room equipped with special color-managed lighting to detected on Mr. Hoover’s arm. ABOUT 55,000 PEOPLE create a mosaic of the patient’s skin. Each photo concentrates on a particular body part, where high-resolution digital images of every After receiving treatment, DEVELOP MELANOMA EACH mole in that area are taken. The mosaic includes areas that are not he was asked to use the normally viewed, like the soles of the feet and the tops of the shoul - digital photos of his body YEAR, AND IT’S THE ders. In the end, more than 40 photos make up the patient’s body for at-home self-evaluations mosaic. Dr. Geskin and her team of physi - between visits to Dr. Geskin’s cians use the photos at each examination to THE BEST OPTION office. Using the mole- LEADING CAUSE OF DEATH IN do side-by-side comparisons of the patient and mapping photos, Mr. his or her digital history. FOR COMBATING Hoover discovered a new WOMEN AGES 25 TO 35 mole on the side of his foot SKIN CANCER IS that was diagnosed as in situ melanoma, or melanoma that In this novel approach, dendritic cells are both “activated” and EARLY DETECTION occupies the top layers of the programmed to stimulate immune responses against cancer antigens. skin, and is easily removed In preclinical studies published in the journal Cancer Research , the with surgery. dendritic cell approach to melanoma therapy has been successful. Mr. Hoover is now 33 years old “Now that we have identified how to take the brakes off the and melanoma free. His visits to immune system and trigger it to fight cancer cells, we can shrink Dr. Geskin’s office have gone from melanoma tumors and help prevent relapse,” says Dr. Kirkwood. Onemillionthanks quarterly to bi-annually. He con - “Interestingly,” says Dr. Falo, “this approach was first discovered tinues to monitor himself using his in humans, rather than animals, as is usually the case. We have now In April 2006, retired United States Steel Funding from The Sandra and Thomas mole map while taking precautionary validated the approach in animal models and are using results from Corporation CEO and chairman, Thomas Usher Endowed Chair in Melanoma will measures such as wearing hats and sunscreen animal studies to improve vaccines for patients.” Drs. Kirkwood Usher, and his wife Sandra donated $1 mil - dramatically augment the growth and pro - outdoors. “My experience with Dr. Geskin and and Falo agree their findings show promise for the development lion to the University of Pittsburgh Cancer ductivity of the melanoma program under her staff has been incredible. I highly recom - mend the program to anyone who thinks he or of vaccines that require cellular immunity, including those directed Institute’s melanoma program. The Sandra Dr. Kirkwood’s direction. The chair will pro - toward viral and bacterial infections and cancer. In the next year, she might be at risk, and is willing to take the and Thomas Usher Endowed Chair in vide permanent funding for the recruitment they expect to initiate a clinical trial based on this approach for initiative,” says Mr. Hoover. Melanoma will aid in the diagnosis and of new faculty who ultimately will be Dr. patients with melanoma. treatment of melanoma. Mr. Usher is Kirkwood’s successors in leading melanoma a melanoma survivor and patient of research at UPCI. Dr. Kirkwood’s who was diagnosed with the disease in 1998.

John Kirkwood, MD, and Louis D. Falo Jr., MD, PhD

8 UPMC Cancer Centers University of Pittsburgh Cancer Institute 9 “WHY New Program Gaining Insight into the Causes of Cancer ?” MEby Clare Collins

t was only six months after treatment for head and neck cancer when Lynn Durkin

Ifound out that she was pregnant. She was happy, if not stunned, by the news that

came after surgery to remove 28 How can we find a cure for cancer lymph nodes, multiple doses of if we don’t know what may have caused chemotherapy, and more than 30 it in the first place? radiation treatments for a cancer

most often diagnosed in older men who drink and smoke. After treatment and follow-

up scans, she was deemed cancer free by her medical team and gave birth to a healthy

baby girl in February 2006. Ms. Durkin now finds herself thinking about why she ended

up with this particular cancer, her risk for recurrence, and perhaps most importantly,

her young daughter Jillian’s risk for disease in the future.

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10 UPMC Cancer Centers University of Pittsburgh Cancer Institute 11 continued from page 11

When you have cancer, you ask yourself, ‘What is it that made me get this cancer? “ Was it something in my family? Was it something in the air?’

You worry about all of that,” says Ms. Durkin. “And, when you become pregnant, you want to know what

you may be genetically passing on to your child. I would love to know that my daughter will

never have to think about cancer.

Emanuela Taioli, MD, PhD, an expert in demiology at the University of Pittsburgh “As more and more people are living with cancer risk and individual susceptibility and Graduate School of Public Health and of cancer — the National Cancer Institute director of Cancer Prevention and hematology and oncology at the University estimates that more than 10 million people Population Science at the University of of Pittsburgh School of Medicine, will living in the United States either have had Pittsburgh Cancer Institute, hopes to gain examine the differences between people cancer or are currently under treatment for the insight needed to answer these questions ”who are healthy and those who develop dis - it — we need to shift our focus to address by examining the factors that put a person at ease. By studying the lifestyles and genetics the needs of survivors who are at great risk risk for cancer. She is conducting research of people who remain cancer free, Dr. for recurrence and new cancers,” says Dr. to better understand how lifestyle, genetics, Taioli and her co-investigator, Lyn Taioli. “The most significant impact that and the environment are linked to disease by Robertson, DrPH, hope to develop a can be made on cancer survival is to pre - examining the ways these factors interact. model of cancer prevention that will shed vent the disease from occurring in the first light on the factors that cause cancer and place through an increased understanding In May, Dr. Taioli’s research was given a how they interact with biology to put of cancer risk and individual susceptibility. major boost from The Arnold D. Palmer people at risk. Greater knowledge will lead us to effective 2003 Charitable Trust in the form of a $2 methods for preventing cancer, bringing million gift to create The Arnold Palmer In another project, Dr. Taioli will follow renewed hope to cancer survivors and their Endowed Chair in Cancer Prevention. The cancer patients over time to learn more children who may have concerns about funding has enabled her to begin a partner about their risks not only for recurrence, their own risks for cancer.” project with Panera restaurants in but for the development of new, so-called Pittsburgh to develop a registry of individ - second primary cancers. Dr. Taioli explains Lynn Durkin cannot agree more. “How can uals who will be surveyed about their that while cancer prevention is traditionally we find a cure for cancer if we don’t know health histories and behavioral choices. aimed at people who have never had cancer, what may have caused it in the first place? Through the surveys and follow-up it is also important for survivors, who should That is the key.” interviews, Dr. Taioli, a professor of epi - continue to be screened and fully moni - tored to learn more about their unique risks for the development of new cancers.

12 UPMC Cancer Centers University of Pittsburgh Cancer Institute 13 Local grade school students from the Pittsburgh area contribute their time and talents by making cards for patients on holidays, birthdays, and other special occasions.

VOLUNTEERS erving within five designated areas After completing a thorough application IMPROVING QUALITY OF LIFE FOR PATIENTS AND THEIR FAMILIES based on their skills and interests, process, each volunteer is placed in an area including patient and family support, that will best serve him or her, as S Another popular by Carey Anne Zucca laboratory research, administrative support, well as the patients. “We do our best to program is bingo Patients who come to UPMC Cancer Centers are given the best treatment and care available by a the Healing Power of the Arts, and special meet the volunteer’s expectations while ful - night, hosted by a group of volunteers from comprehensive team of oncologists, nurses, social workers, and other health care professionals. There events, volunteers range in age from filling patient needs,” explains Zuleikha teenagers to senior citizens. Each gives his Bjork, assistant program coordinator, PNC Bank. This event is held on the is another very important component of that team: volunteers. More than 200 volunteers at UPMC Cancer Centers or her time for a variety of reasons. Some UPMC Cancer Centers and UPCI oncology inpatient units twice a month. and the University of Pittsburgh Cancer Institute (UPCI) help to improve the quality of life for patients volunteers are students who are interested Volunteer and Community Services. “It’s “It’s a fun activity that is close to the patient and their families by providing support on many levels throughout the cancer continuum. in gaining experience in research laborato - really a partnership among the staff, volun - rooms, making participation easy for ries or other areas, some have lost a loved teers, and patients.” patients and family,” says Ms. Huntley. one to cancer and want to give back as Volunteering is not limited to site visits at part of the healing process, and others are Hillman Cancer Center and the oncology retired members of the community who Unique Programs for Patients inpatient units at UPMC. A group of vol - have time to give. unteers known as “Project of Love” work Volunteers at UPMC Cancer Centers coor - “Our volunteers are a very dedicated out of their Beaver County homes to make dinate a variety of programs and engaging group,” says Lisa Huntley, director, UPMC turbans and pillows for cancer patients. activities for patients and family members. Cancer Centers and UPCI Volunteer and These are sent to Hillman Cancer Center as For example, through the Healing Power of Community Services. “Volunteers come to well as the other cancer center locations for the Arts Program, volunteers host craft the Hillman Cancer Center for a variety of distribution. Another group of volunteers classes on the oncology inpatient units reasons but they all offer compassion and who are part of the US TOO! Prostate Peer located at UPMC Shadyside at least twice a their commitment of time to help our Counselors Group donate their time by week for cancer patients, family, and staff. patients and staff.” making phone calls to newly diagnosed The volunteers do not need to be trained patients to offer support. artists; for example, class instructors have included a stay-at-home mom, a working continued on page 16 professional, and a cancer survivor — all people who simply enjoy sharing their crafts. The arts program also features local musicians, such as those from the Carnegie Mellon Arts Alliance, who perform for the patients on the oncology inpatient units or at the Hillman Cancer Center Atrium.

14 UPMC Cancer Centers University of Pittsburgh Cancer Institute 15 VOLUNTEERS

offering companionship, supporting administrative needs, and assisting in research labs

The Lady With the Crazy Tights tored closely by his cancer care team. He is now 16 for the Cure to support breast cancer research years old, and patiently waiting to begin driving. and Pittsburgh’s Annual Walk for the Whisper Jennifer Kirsch is referred to as “the lady with the “The care my mother and my neighbor received at that raises money for ovarian cancer research. TURNING TRAGEDY TO crazy tights” by the patients on 7-West at Hillman Cancer Center inspired me to volunteer UPMC Shadyside Hospital where oncology there,” says Ms. Kirsch. A volunteer recognition luncheon also is held patients are treated. When she is not volun - annually to honor and celebrate the volunteers for teering for the UPMC Cancer Centers and Ms. Kirsch volunteers for at least four hours one their hard work and dedication to the program. UPCI Volunteer and Community Services night a week during the school year. She has HOPE Department, she is teaching seventh grade developed many wonderful relationships with The Volunteer and Community Services staff patients since she began volunteering in October is continually looking for ways to meet the needs English at North Hills Junior High School. efore Lisa Huntley became the director of the UPMC Cancer Centers and the 2004 and has become known as the “lady with of patients and staff. In spring 2006, a book and Ms. Kirsch’s mother is a four-and-a-half-year the crazy tights.” “If I make one person laugh or magazine cart for patients, family, and visitors University of Pittsburgh Cancer Institute’s (UPCI) Volunteer and Community breast cancer survivor whose oncologist is affili - smile just by looking at my tights, I know I’ve was added to the list of services as a result of Services Program, she was like most other volunteers, donating her time to ated with Hillman Cancer Center. When Ms. brought him or her out of his or her element even B donations from the volunteers at PNC Bank as patients fighting cancer to honor the memory of a loved one. Kirsch’s neighbor was diagnosed with advanced for a moment,” she says. well as the general public. The items from the melanoma at age 12 in the fall of 2002, she cart are free for people to keep, as long as books Ms. Huntley’s late husband, Grant Channell, was diagnosed with melanoma in 1989 decided she needed to become a volunteer. “Too and magazines continue to be donated. at age 22. Two short years later, Mr. Channell’s cancer metastasized to his bones many people get out the checkbook as their only Supporting an Ongoing Need and lymph nodes, leading him to seek treatment from world-renowned melanoma form of donation,” says Ms. Kirsch. “Writing a “The UPMC Cancer Centers and UPCI specialist, John Kirkwood, MD, professor of medicine and dermatology; vice check is too easy, and after seeing what my In addition to daily support, Volunteer and Volunteer and Community Services Program neighbor was going through, I decided I wanted Community Services also hosts a number of spe - has grown tremendously over the years, and will chairman for clinical research, Department of Medicine, UPMC; and director, to actively donate my time.” cial community events throughout the year to continue to play a vital role in the ongoing care Melanoma and Skin Cancer Program, University of Pittsburgh Cancer Institute. The honor patients with cancer, while raising money of patients,” says Ms. Huntley. unusually virulent nature of Grant’s cancer ended his life in the fall of 1994. Her neighbor had to undergo four weeks of and awareness. The Daffodil Days campaign has Interferon treatments at Hillman Cancer Center, raised the most money for the American Cancer About one year after her husband’s death, Ms. Huntley began volunteering at UPCI followed by 48 weeks at home, while being moni - Society Greater Pittsburgh Unit for eight consec - with a friend. Volunteering led to a greater interest in helping to develop the pro - utive years. The department also is an active gram. Ms. Huntley was hired as assistant director of the Volunteer and Community participant in the national Susan G. Komen Race Services Program in fall 1997 and became director in fall 1999.

Ms. Huntley organizes the annual Grant Channell Memorial Golf Outing to support the Melanoma and Skin Cancer Program at UPCI. More than $120,000 has been raised from this event. This year’s activities were expanded to include the first annual Grant Channell Memorial Skin Cancer Screening, held in July 2006. More than 100 people participated in this prevention and early detection event, A group of volunteers known as “Project of Love” work resulting in 22 referrals for a benign condition, and 12 referrals for biopsy. out of their Beaver County homes to make turbans and pillows for cancer patients. 16 UPMC Cancer Centers University of Pittsburgh Cancer Institute 17 THE POWER OF PARTNERSHIP Michael Fader Peggy and Jack Offenbach LEADERSHIP CIRCLE Diane Faust and Barry Lembersky, MD Sandy and Gene O'Sullivan ($5,000-$9,999) Berrylin Ferguson, MD, and Kenneth McCarthy, MD, PhD Kit and Arnold D. Palmer Susan and Michael Boyle Thanks to the continuing support of our donors, the University of Pittsburgh Cancer Institute and UPMC Cancer Stephanie and Thomas Flannery Leah M. Pasquerilla Suzanne and Robert Chute Kim H. and Curtis D. Fleming Lisa and Mark E. Pasquerilla Centers are translating new discoveries in the laboratory into effective methods for preventing, detecting, and Elizabeth and Michael Concordia Foster Charitable Foundation Kathy and Demetrios Patrinos treating cancer. Gifts received during fiscal year 2006 are bringing renewed hope to cancer patients and their Jane and William S. Conover II at the recommendation of Izzy and Lee Foster F. Fred Pezeshkan families in our region and beyond. It is with deepest gratitude that we recognize our partners — individuals, families, Rosemarie and Robert Coury Jane K. France and Christian L. Allison Larry Pietropaulo Ranny and Jay Ferguson businesses, corporations, foundations, and organizations — for their ongoing support of our mission to build a Chip Ganassi Mary Jane and Joe Platt Jr. John J. Fromen Jr., Esq. Rebecca Garrett, MD, and Kenneth Foon, MD Donald Plung future without cancer. Jennifer and Donald P. Fusilli The Genge Family Joanne Pobiner and Alan Ziperstein Joyce and Stanley H. Goldmann Sandra and Lee Goodman Hilary and Charles Porter Nanette and Ira Gordon Ellen R. Goodman David Rath ENDOWED CHAIRS FAMILY LEGACY SOCIETY ANNUAL GIVING Mary Jane and Carl G. Grefenstette Gott Family Foundation Lillian S. Rath A. Richard Kacin The Annual Fund provides vital support for the operation of Kathryn and Vincent Gray Diana and Frank Rath An important number of endowed chairs support the mission of Often, a personal experience with cancer or the loss of a loved one Hannah and Marvin Kamin clinical programs, basic and clinical research programs, Thomas B. Grealish Joseph Rattner Memorial Endowment Fund UPMC Cancer Centers and the University of Pittsburgh Cancer to the disease spurs a family to establish funds that honor the patient The Lee Family Foundation - Ilda and Charles Lee recruitment of new physicians and scientists, seed money Sara and Alan Guttman Rauch Foundation Institute. The income generated from endowed chairs enables our through support of continuing efforts to better detect, prevent, and Simone and Scott F. Lutgert support, medical and patient education, and outreach pro - Susan G. and Barney C. Guttman Riggs Industries, Inc. scientists and clinicians and their teams to strengthen established areas treat cancer. Helen Fricke Mathieson grams. Those listed have made sustained annual investments Joseph Hardy Sr. Roesch Family Foundation of expertise, expand new initiatives, and forge new frontiers in science Gary Morrell at the following designated levels. Hawksglen Foundation Stefania and Jeffrey Romoff that benefit our patients and their families now and into the future. Suzanne Hill Alfano Endowment for Lung Cancer Research Kirk Posmanture Heidi and Robert E. Heltzel Patricia and Daniel M. Rooney Nathan S. Arenson Fund for Pancreatic Cancer Research Sylvia and Donald Robinson Harriett L. and Ronald B. Herberman, MD Cynthia Roth and James Kunkel, MD The Claude Worthington Benedum Endowed Chair Beckwith Family Foundation ______Carole and John F. Scalo Steven Herforth and Peter Karlovich Jr. Diane and Cliff Rowe Jr. in Radiation Oncology Endowed Research Scholars Program CIRCLE OF HOPE The Bachmann Strauss Family Fund, Inc. Dwight E. Heron, MD Linda and James Rumbaugh The Richard M. Cyert Endowed Chair in Molecular Oncology The Heidi Browning Endowed Ovarian Cancer - Bonnie and Thomas Strauss The Circle of Hope honors individuals, family foundations, and Margaret M. and John B. Hill, MD Abby and Reid W. Ruttenberg The Lawrence Ellis Endowed Chair Research Scholars Fund Jay Vetere privately held companies that make contributions of $10,000 or more Elsie H. and Henry L. Hillman Myles D. Sampson in Hematology and Oncology Ruth C. Brufsky Fund for Clinical Research Trudy and Lawrence M. Wagner in a calendar year. This list recognizes those who were members in Carolyn and Gerald Hindy Kim and Ben Sampson The Bernard Fisher Endowed Chair in Surgical Oncology on Pancreatic Cancer Maureen and John J. Waldron 2005 and through 2006 to the time of publication. Cathy and Sy Holzer Susan Santa-Cruz The Giant Eagle Foundation Endowed Chair Patti Burns Fund Eleanore G. Wyckoff in Cancer Genetics Gregory T.H. Davies Brain Tumor Research and Physician Susan and Michael W. D. Howell Cynthia and Keith M. Schappert Laurie and Joel Adams The Hillman Endowed Chair in Oncology Education Endowed Fund Jean and Samuel Jacobs, MD Mikell and A. William Schenck III ______American Municipal Securities The Arnold Palmer Endowed Chair in Cancer Prevention Dr. Joan G. Gaines Breast Cancer Research Fund Betsy and Robert Kampmeinert David S. Shapira PARTNERS FOR PROGRESS The Sampson Family Endowed Chair Stuart Goodman Brain Cancer Memorial Fund at the direction of Janet and Robert Cline Tricia and William Kassling Edith Shapira, MD, and Mark Schmidhofer, MD ($1,000 - $4,999) in Thoracic Surgical Oncology Peter E. Hackney Fund for Pancreatic Cancer Research Bruce Americus Karen and Joseph L. Kelley III, MD Barbara and Herbert Shear Virginia and Don E. Ackerman The Sandra and Thomas Usher Endowed Chair in Melanoma Dr. Herbert E. Jacob Memorial Fund Lee R. Anderson Gauri Kiefer, MD, and Jan Kiefer Sherman Family Foundation Barbara J. and P. David Adelson, MD The UPMC Endowed Chair in Head and Neck Barbara Klump Memorial Scholarship Fund Anonymous (2) Maryann and Edward Kilkeary Jacqueline and Jeffrey Shogan, MD Adrianne and Curtis E. Aiken Cancer Surgical Research Albert P. Knowles Research Fund Patty Baker and Jay Baker Christopher H. Koch Patricia and William Snyder Martha and Anthony J. Alfano David C. Koch Memorial Fund Rosalie Barsotti and Tony Poli Valerie R. Koch Thelma Snyder, DMD, and Marc Liang, MD Nicholas James Alfano ______Mario Lemieux Patient Care and Cancer Research Fund Dorothy B. and G. Nicholas Beckwith III Laura and Claude Kronk Rhea and Guy Squillante Matthew Allaway VISIONARY SOCIETY Scott Limbach Entrepreneurial Center The Bittner Family A. Lorraine and Ignatius* Laux Jerry L. Starkey Lawrence R. Andrews Stanley M. Marks, MD, Endowed Research Fund Nadine E. Bognar Nathalie and Mario Lemieux Stork Foundation These dedicated partners have given or helped to raise a cumulative Bonnie B. and Richard Paul Anton, Esq. Drew Mathieson Entrepreneurship Fund Mary Ann and Charles Bogosta Robert Levin Marcia and Perry Swanson total of $1 million or more in support of cancer research and care. Jill and Dennis L. Astorino James A. Mollica Jr. Research Endowment Fund Luiza and Andre Brett Sally Levin Pamela and Markos Tambakeras Jean and Louis D. Astorino PNC Innovation Fund Sonia and Robert Browning Edward J. Lewis Tippins Foundation American Cancer Society, Incorporated Kimberly and Peter M. Augustine Michael J. Parada Research Fund Jill Brufsky, Pharm D, and Adam Brufsky, MD, PhD Shelley and Jeffrey Lipton Gayle L. Tissue and Yiannis Kaloyeropoulos The Giant Eagle Foundation Amada and Rashid A. Awan, MD Mark E. and Leah M. Pasquerilla Tamar and Seth Brufsky Christine and James D. Luketich, MD Sandra and Thomas Usher Highmark Foundation Komal and Sanjeev Bahri, MD Women’s Cancer Research Fund Barbara and Gerald E. Chait Carol and Thomas Lund Bonnie W. and Thomas L. VanKirk, Esq. Elsie H. and Henry L. Hillman William R. Baierl Pasquerilla Cancer Genomics and Proteomics Research Fund Sandra S. and Richard A. Cohen Maggie Hardy Magerko and Peter Magerko Kristina and William Watts The Henry L. Hillman Foundation Ann and William W. Bain Jr. The Spang Translational Research Core Facility Caryn and Sam Covelli Stanley M. Marks, MD Marilyn and Norman Weizenbaum The Hillman Foundation Susan and David Bartlett, MD Joseph and Giovanna Tarquinio Memorial Fund Barbara Ann and Robert A. Crown Mars Family Charitable Foundation Debi and Harold Wheeler III Family and Friends of Albert P. Knowles Barbara A. Dappert, MD and Michael J. Becich, MD, PhD Wayne Fusaro Pancreatic Cancer Research Fund Randi and L. Van Dauler Polly and William T. Marsh Jennifer and David Wheeler Family and Friends of David C. Koch Elaine Bellin Dr. Leonard S. Zombek Memorial Fund Barbara and Randy Davies Myrna and Mark Mason Joan Wheeler Mario Lemieux Foundation Jamini Vincent Davies Roma and James May Stacy and Paul Wheeler Patti and Sanford S. Berman Richard King Mellon Foundation Devra Davis, PhD, MPH, and Richard D. Morgenstern, PhD Kevin McClatchy Priscilla and Joseph Whiteside Marjorie Romkes, PhD and William L. Bigbee, PhD Arnold D. Palmer 2003 Charitable Trust Debra and William S. Demchak Linda and David McKamish Josephine and S. Donald Wiley Bonnie and H. Vaughan Blaxter III Mark E. Pasquerilla Mary Lou and Richard Durr Michele McKenney and Charles C. Cohen Enid and Richard D. Wood, PhD Linda and Anthony J. Bonidy PNC Financial Services Group and PNC Foundation John Elliott II Kathleen and David McSorley * deceased Edward J. Borkowski Myles D. Sampson and Family Lori and Peter Ellis, MD Jane and Edward Moravitz Kerry and Paul Vincent Boulian Sandra and Thomas Usher Augie K. Fabella II Antonio F. Moretti, MD Joan and Arthur Dean Boyd, MD Wheeler Brothers, Incorporated Gloria Fader John L. Brottem

18 UPMC Cancer Centers University of Pittsburgh Cancer Institute 19 Emily Kleiman Bua Franco Harris Vicky Merryman Suzanne and Richard L. Wagner Elizabeth and Samuel H. Hollingsworth Jr. Farley Walton Whetzel and Joshua C. Whetzel Jr. Michele Buck Ross Harrison Kimberly and James H. Meyers, MD Matthew B. Waldman Fannie and Quennon A. Hundley Michael John White, MD Tracy Seewald, MD, and Steven A. Burton, MD Marissa and Burt Hartington Nancy and James C. Miller Caroline and John L. Walker Sandra and Edward A. Jaeger, MD Barbara L. Widdoes Sara and John W. Buss Jr. Gregory C. Heins Kenyon Milligan Norma and Charles J. Walsh Josette Janczak Elisabetta and Kurt Wiedenhaupt Brenda and Joseph L. Calihan Sarah and C. Talbot Heppenstall Jr. Elizabeth and John A. Moore Sara and Larry Walsh Janet and Morris J. Kaplan Sally Wiggin J. Glennon Campbell Betty and Rodger Hess Mike Moulton Annette and Robert S. Werner, MD Susan Katz Kathleen and Theodore J. Williams Thomas Leake Campbell Jr. Carl Hilbert Maureen and James Murphy Becky and Tom Wild Susan Rita Kinsey, PhD Bryant Yunker Mary Ellen and Russell Cersosimo Peggy Hill Tessa and David Nicholson Michael L. Williams Pamela and D. Scott Kroh Walter R. Zoladz III Rebecca and Gurkamal Chatta, MD Mary and Thomas M. Hill Clark Nickels Deidre Foley-Woods and Denis Woods Susan and Scott M. Lammie * deceased Gene P. Ciafre Audrey and Thomas J. Hilliard Jr. Thomas H. O'Brien Mike Yannazzio Claire and Lawrence Levine Bonnie and Robert J. Cindrich, Esq. William A. Hite Brian J. O'Mara Ruth A. Zittrain, Esq. Luyuan Li, PhD ______Connie and Bruce T. Cleevely Dale R. Hoffman Janice and Richard A. Pagliari Mignon and Waldemar Love AMBASSADORS Brian Cobb Mark R. Hoover Leslie and Joseph F. A. Petrone, DDS ______Annette and Gary Luchini ($250 - $499) Charles L. Cost Thomas J. Horan Nicole and Joseph Piccirilli CHAMPIONS Charles I. Lytle II David P.M. Armstrong Carol and Gary S. Cozen Ed Huling Patricia and Vincent J. Quatrini Jr. Lois and David E. Malehorn ($500 - $999) Donald B. Arnheim Mary and William G. Cramer Aura R. Hulme Rosemarie and Kiran Rajasenan Lucine Marous and John Marous Jr. Elinor M. Abplanalp Dawn and Raymond D. Ball David J. D'Antoni Richard A. Hundley Jothi and Ramesh Ramanathan, MD Helen and Curtis R. Marquard Florence L. Allen Mary and Richard M. Beck Ada and George A. Davidson Jr. Cecelia and Frank G. Jaworowski John P. Reisman Leslie and Randall McCombs Glenn W. Arthurs Kenneth and Brandon Bernstein Malindi Davies LaVonne and Glen R. Johnson Linda Barry Robertson, DrPH, and Walter J. Robertson Anne and William O. McConnel Barbara L. Barry Charles Kuang Ming Brown, MD, PhD Christopher D. Decker Janis and Dr. Jonas T. Johnson Sharon and James E. Rohr Kristi and Tom McGuire Rhodora and Dick K. Barton Nicole R. Brown Daniel W. Deis Peter J. Kalis Margaret and Robert G. Runnette Denise Medwick, DO, and Gerald Medwick, DO Mary Murtland Berger Diann M. Bruni Dolores and Joseph W. DeNardo Daniel Kamin Cindy and Andrew Russell Alexis M. Megaludis, MD Rebecca J. Beward Jerry R. Burns Katherine DeSimone, Esq., and David R. DeSimone, Esq. Irene and Kevin M. Kane, MD Dorothy N. Saladiak, PhD Constance and Bruce W. Morrison Minnette D. Bickel Demetria and Richard G. Cefola Patricia and James C. Dewar David N. Kaplan Nancy and Hugh D. Sansom Teresa Nolan Flonet and Renard L. Biltgen Ruth Collodi Douglas P. Dick Christina and Brian J. Kassalen Kenneth Schiebel Janet F. Palumbo Dolores M. Bold Brian Cook Robert C. Dickman Wallis and Marshall P. Katz Tamara and Matthew D. Schneider Janet Ocel, PhD, and Paul Paris, MD Karen and Glenn A. Buterbaugh, MD Elisa D. Harris and Ivo H. Daalder Rhodora and John F. Donahue Christine Kealey Eileen C. Schwab Arlene and Thadeus M. Pawlikowski Robert Campana Dan Daddario Kevin C. Dunphy James E. Kelly, Esq. Amy and Sean Sebastian Cathy and John H. Pelusi Jr. William H. Chambers, PhD Joyce and Martin J. Dambekaln Lisa and Martin F. Earle, MD Nancy and Robert E. Kelly Jr. Barbara and M. Alfred Seltman, DMD Matt Perachi Manisha and Preet M. Chaudhary, MD, PhD Rosemary and Alex Debiase Lowrie Ebbert Taylor Kincaid Bruce Sherman Helana and William Pietragallo II, Esq. Lin-Li and Alex Chen, MD Lynn E. Dee Karen and Merrill Egorin, MD Robin Kinney Virginia and Richard P. Simmons Michael P. Pitek III Sally Hillman Childs John E. Defibaugh Dr. Robert Elkins Kathryn and Cary H. Klein Retta and Elliott Singer Joann and Charles J. Queenan Jr. Lalit Chordia, PhD Deborah and Paul Detwiler Sally and Terry L. Evans, MD Ruth Ann and Eugene J. Klein April and Lawrence J. Sipos, Esq. Sally and Edward V. Randall Jr. Frederick D. Clemente Dr. Tarit Kanti Dutta Greg Ewing Jeff Kmiec Mary and Joseph Smallwood Melissa and Robert M. Reed II Daniel Cohn Mary Ruth Sampson Eckman Nellie C. Fain Mary Knowles and Ken Burgess Susan Berger Smerd, PhD, and Peter Smerd John F. Rehak Darin Conti Colleen M. Ellis John T. Fenner Julie A. Koch Sally and Lee F. Snyder Suzanne and William W. Rielly Sr. Mary and Maris Dambekaln Ingeborg and Richard J. Farrell Mary Ellen and William A. Ferri Jr., MD Nancy and Richard P. Krieger Norma and Michael N. Sobel, DMD Susan and Joseph G. Robinson Jr. Judy and Richard Davies Charles Ferguson Milton Fine Revocable Trust - Sheila and Milton Fine Jennifer and Keith D. Kronk Teri and R. Damian Soffer David M. Roderick Ellis S. Day Jr. Robert Louis Ferris, MD, PhD Edith and James A. Fisher Beth and Michael R. Kuhn Jeffrey W. Spear, Esq. Judy and Stanley C. Ruskin Margaret and Daniel A. Desko Randall J. Frantz Nina Fisher Andrew D. Laman, MD Silvia and Alexander C. Speyer III Nova and Devon Ruttenberg William S. Dietrich II Richard A. Frantz Deborah Flaus Lee Ann and Richard F. Lamb Anthony Spinola, MD Maureen and Richard J. Saab, MD Diane and Mark Dorogy Beth Ann and Frank B. Fuhrer III Charlene and John P. Friel Frances and Stewart L. Lancaster, MD Mary Jo and Frank M. Spinola Nancy Bernstein and Robert E. Schoen, MD, MPh Mary Jo and Terry L. Dunlap Lisa Gabrieli Hilda and Freddie Fu, MD Carol Larson Valerie J. Stabile Nancy and Richard S. Scott Nicole and Michael Eisenberg Marie and Floyd R. Ganassi Clare Collins and Brian P. Gabriel, Esq. Mary Beth and Christopher Leech Nancy and Ronald G. Stoller, MD Mary and Richard Skubak George A. Fechter Mary and Dr. Robert C. Gast Connie and Thomas R. Galloway Sr. Ann and Paul E. Lego Kirsten and Edward M. Stripay Jr. Frank Neal Snyder Jr. Joseph Ferens Heidi and Dr. Stanley J. Gorski Sandra and Alvaro Garcia-Tunon Susan T. Silversmith and Lawrence F. Leventon Barbara H. and Thomas Sturges W. R. Stromple Karen L. Ferri, Esq. Dr. Barbara-Ann K. Greenberg Marcia Swartz Glosser, MD, and Daniel Glosser Elsie Y. Lewis Elizabeth and John P. Surma Jr. Cindy and David P. Swanson Lilian H. Fisher Paula E. Halligan Sally Weigler Golden and Thomas B. Golden Jr. Judith and Ronald G. Linaburg, DMD Diane and Regis J. Synan Emilie and Charles H. Sykes, MD Robin and Patrick A. Gallagher Sylvia and Daniel Eric Johnson, MD Lee and J. Roger Glunt Terri and Timothy J. Logan Janet and George H. Taber Robert Timins Michael Gelman Pawel Kalinski Gray Gonez Susan J. Lyons Evelyn O. Talbott, DrPH, and John B. Talbott, MD Barbara Ellen Trachtenberg Richard Giffhorn Diane C. Katz Jennifer Grandis, MD, and Donald J. Grandis, MD Stephanie and Bernard Mallinger, MD Robert W. Taylor Dorrit and David F. Tuthill Sher Leigh and Gary Grelick Steven M. Kinney Patricia and Daniel P. Grealish Linda and James R. Malone Ashley and David A. Tesone II Edward Udicious James R. Grundtisch Tanya and Eugene W. Klaber Ina and Lawrence N. Gumberg Tracey and Robert Marsh Sara B. Thompson Ann and Kenneth Urish Mary and James S. Hamilton Thomas A. Labert Marcia and Stanley R. Gumberg Joan Stein Marshall Virginia and The Honorable Richard L. Thornburgh Sophie and Edward P. Vincent Loretta and Thomas Hanwell Helen Wettach Lang Mosey and Don J. Gunther Peggy and Stephen McKnight Aleida and Frank A. Trisoline Jr. P. A. and W. S. Watkins Eric H. Heinemann* Ann Marie Langerholc Teddi and George A. Hackett Mary L. Means, PhD Debra Anne Udicious Jonathan T. Webber Susan and David H. Hicks Byeong Chel Lee Mary Anne and Howard W. Hanna III Emily S. Mendelson Michael Underhill Peter J. Weidhorn Tracy and J. Craig Hill Yun K. Lee and Yong J. Lee Barbara and Robert W. Hannan Barbara S. Mendlowitz Michael D. Voloshin, MD Susan E. Weintraub Audrey and Thomas J. Hilliard Jr. Marisa Thompson and Alex C. Levine

20 UPMC Cancer Centers University of Pittsburgh Cancer Institute 21 Marie and Henry T. Lyons III ESTATES AND TRUSTS Buffalo Sabres Mine Safety Appliances Co. (MSA) Lendable Linens Canada Hair Cloth Marie and Domenico Mancuso Gardner Carton and Douglas LLP National Ovarian Cancer Coalition Louis Anthony Jewelers Cancer Care Northwest, PS UPMC Cancer Centers and the University of Pittsburgh Cancer Steven M. Massaro Gateway Financial Parsons Brinckerhoff M & T Bank CCIM Institute Institute gratefully acknowledge gifts from the following individual Carolyn Maue and Bryan Hunt Genentech Incorporated PBS&J M & T Insurance Agency, Inc. Chicago White Sox estates and trusts. Anne and William O. McConnel GlaxoSmithKline Pharmion Malady and Wooten Public Relations Chick's Sporting Goods Ski Shop, Inc. Judith and James A. Metzger, MD Hefren-Tillotson, Inc. Pittsburgh Pirates Marsh USA Cingular Wireless Estate of Richard J. Behan Deborah and Dr. Thomas J. Musser Heritage Management Services, Inc. Radelet McCarthy Architects Marshall Elevator Company CME Federal Credit Union Estate of Heidi L. Browning Nicole North Highmark Blue Cross and Blue Shield Respironics McMahon and Cardillo Communication, Inc. Commercial and Corporate Litigation Group Estate of Jane M. Epstine Louis A. Nudi Kennametal Inc. Rugby Realty Merrill Lynch Condron Partnership LTD Estate of C. Gibson and Velma B. Shaw Kaori and Hideho Okada, MD, PhD L-3 Communications, Brashear SAI Consulting Engineers, Inc. Merrill Lynch and Co. Inc. Creative Displays and Packaging, Inc.

Brenda Oliver ______Levin Furniture Schnader Harrison Segal and Lewis LLP MGI Pharma Inc. Creative Stitches by Dina, Inc. Laure Pascale Croisille Peault BUSINESS, CORPORATIONS, ADVOCACY LJ Aviation Simpson McCrady LLC Murrysville-Export Rotary Club Cuppy Real Estate Company Samuel Posner ASSOCIATIONS, AND OTHER GROUPS McKamish, Inc. Sisterson Ogletree, Deakins, Nash, Smoak and Stewart, PC Ditto Vesna Rapic-Otrin, PhD McKesson Corporation Sky Insurance Oil Service, Inc. Easy Street Enterprises LLC Sallie Rawlings UPMC Cancer Centers and the University of Pittsburgh Cancer Mellon Financial Corporation The Hillman Company Perfectly Natural Solutions, Inc. Employees of Michael Baker Corporation Lucile and Ian G. Rawson, PhD Institute gratefully acknowledge gifts of $250 or more from businesses, Mylan Laboratories, Inc. Unither Pharmaceuticals, Incorporated Pietragallo, Bosick and Gordon, LLP Employees of the Ralph A Hiller Company John C. Regan corporations, advocacy associations, and other groups. Nemacolin Woodlands Resort and Spa Veritable, LP Precision Therapeutics Evans Police Benevolent Association Anne and Scott W. Reid Nova Chemicals, Inc. Voyager Jet Center LLC PremCom Corporation Facility Merchandising Incorporated Jeffrey A. Rex ($100,000 + ) Oxford Development Company Wheeler Brothers, Incorporated Pricewaterhouse Coopers Florida Marlins, LP Idamae and James Rich 84 Lumber Company Panera Bread Professional Baseball Promotion Corporation Friends of Wendy Herz Carol and Patrick R. Riley American Cancer Society, Incorporated Pittsburgh Steelers ($1,000 - $4,999) Quaker Capital Management Frith Enterprises Mr. and Mrs. Jeffrey P. Rodewald American Society of Hematology PJ Dick Incorporated and Trumbull Corporation Anonymous Relizon Graciano Corporation Mona and Garson David Roodman Amgen, Incorporated PNC Financial Services Group, Incorporated Architectural Network, Inc. Robroy Industries Hillman Café Staff Robert A. Rorke Anonymous Saks Fifth Avenue Bates Jackson Engraving Company Roche Laboratories, Incorporated Holiday Valley Grace and John N. Scarsellato, MD Fraternity and Sorority Life Office at Solenture, Inc. Benkovitz Seafoods and Nordic Fisheries RSM McGladrey, Incorporated Hyatt Regency Gilbert Schnaufer the University of Pittsburgh The Buncher Company Boncraft Incorporated Scientific-Atlanta, Inc. It's All Made Up, Inc. Mary Kathryn Schneider Magee-Womens Research Institute Tibotec Therapeutics CCF Agnes and Francis Cosgrove Memorial Simon Malls Jaeckle Fleischmann and Mugel, LLP Anita and Michael Shedlock sanofi-aventis Group Tube City Division, Tube City IMS Cerner Corporation Smurfit-Stone Container Enterprises, Inc. James Services Barbara and Dan Simanek The Leukemia and Lymphoma Society University of Pittsburgh Medical Center Choice Marketing Co. Susquehanna International Group, LLP JDK Design Cathy and Ron R. Smith United Way of Allegheny County Wabtec Corporation Ciphergen Biosystems, Inc. Systems Management/Planning, Inc. Joseph Elias Charitable Trust Lois and Ross H. Smith Jr., MD Cohen and Grigsby, PC Tex's Auto Sales KDKA Radio Patricia G. Snyder ($50,000 - $99,999) ($5,000 - $9,999) Colgate-Palmolive Company The Pittsburgh Athletic Association Kelly-Rielly-Nell Associates, Inc Nancy and Joel H. Solomon Acosta Sales and Marketing Company Active Media Services, Inc. Countrywide Financial The Stamm Jackson Family Lia Agency, Inc. Rosemarie Navarro Spinola American Eurocopter An EADS Company BAA Pittsburgh, Inc. Creditors Interchange Thomas M. Reich and Associates Madsen, Sapp, Mena, Rodriguez and Co., PA Christine Stanko American Heart Association Burt Hill CTR Holdings, Inc. Uniontown Hospital Managers Investment Group, LLC Kristie and Tim Steitz Anonymous (2) Cardinal Health, Inc. Cumberland Valley Breast Care Alliance United Parcel Service Marcus and Shapira, LLP Hayes C. Stover Pepsi Bottling Group, Inc. Carmel Partners, Inc. Curbell United States Gypsum Company Material Science and Technologies Julia H. Tamkevicz Pittsburgh Wine Festival CDM Dress Circle Inc. Van Dyk Business Systems Michael Baker, Jr., Inc. Sylvia M. Thompson United States Steel Corporation Celgene Corporation Easley and Rivers, Incorporated VIACOM Television Stations Modell's, Inc. Criag S. Torell Comcast Eastman Machine Company Walnut Capital National Emblem, Incorporated Patricia and David L. Townsend ($25,000 - $49,999) Coury Financial Group, LP Evans National Bank West Herr Automotive Group, Inc. NBA Properties, Inc. Lisa and Peter J. Walsh Abraxis Oncology Duane Morris LLP Excela Health Yates-Fund for Cancer Hope New Era Cap Company, Inc. Janis and James I. Warren American Society for Therapeutic Radiology Oncology Eat'n Park Hospitality Group, Inc. Eyetique Corp. Partners In Change, Inc. Barbara and Norman H. Weber Jr. CJ Systems Aviation Group Eckert Seamans Cherin and Mellott, LLC Family of Jean Van Guilder ($250 - $999) Pathology Oncology Informatics Team Marcia J. Weiss Dee Dee Sacco Fight For Life Fund Elliott Company Federated Investors Incorporated Accordia, Inc. PI Management Resources Marcy Wilkerson Eckerd Esophageal Cancer Awareness Assoc. Inc. Goodlette, Coleman and Johnson, P.A. AFGE Local 644 Charities R. W. Caldwell Associates Inc. George C. Wilson III Frito-Lay Fiserv SourceOne GPS Construction Services LLC Airports Council International - North America Robert Half International Inc. Robert W. Wilson General Mills, Inc. Fort Pitt Capital Group, Inc. Grubb & Ellis All In Good Taste Productions, Inc. Roberta Weissburg Leathers Loreen and Ronald L. Witt Major League Baseball G & G International, LLC HealthNow New York, Inc. American Eagle Outfitters, Inc. S. M. Cristall Company, Inc. Anton A. Zaspel Snyder's of Hanover, Inc. Giant Eagle Heartland Homes, Incorporated Arch Coal, Inc. San Diego Padres, L.P. Joseph J. Zwirecki Wayne Fusaro Pancreatic Cancer Research Fund Gist Cancer Research Fund Hire Demand, LLC - Gina Shaffer Baker Employees Combined Charities Selections by Genea and Eric Grant-Oliver Corporation HVL Incorporated Bank of Florida Springdale After Prom Committee '07 ($10,000 - $24,999) Henderson Brothers, Inc. IBEW Local Union No. 5 and Western PA Chapter, Barudan America, Inc. St. Louis Cardinals Ch. Shop, Inc. Adams Capital Management Inc. IKM Incorporated NECA Labor Management Cooperation Committee Bayer Employees Federal Credit Union The Fluted Mushroom Catering Co. American Academy of Otolaryngology Ladies Hospital Aid Society of Western Pennsylvania InterPublic Group Black Hawk Golf Course The Holden Corporation American Textile Company Management Engineering Corporation Jas H. Matthews and Co. Educational and Charitable Trust Boland Sales Company, Inc. The United Way of Washington County Antigenics, Inc. Medrad L. Robert Kimball and Associates, Inc. Bontex Theta Phi Alpha Kappa Chapter Aramark Corporation Michael Baker Corporation Larry Potter Memorial Fund Bunzl USA, Inc. Thorp, Reed Armstrong, LLP Buchanan Ingersoll, PC

22 UPMC Cancer Centers University of Pittsburgh Cancer Institute 23 Three Rivers Entertainment Inc. The Luminescence Foundation, Inc. Susan L. Stepchuk Louis Anthony Jewelers University of Pittsburgh Department of Athletics UPMC CANCER CENTERS AND Tucker Arensberg, P.C. The M & T Charitable Foundation Elaine J. and Rodger G. Temple Kevin McClatchy University of Pittsburgh Police Department UPCI DEVELOPMENT DEPARTMENT Victor Forstmann, Inc. The Matthew Hillman Fisher Foundation, Inc. Kristy L. Terling Fire Inspector Floyd McCrea — Chief Tim Delaney Jennifer Raetz, Development Director Walt Disney World Dolphin The Pittsburgh Foundation Bonnie W. and Thomas L. VanKirk, Esq. Carol Maltby UPMC Emergency Medical Services Sally Weigler Golden, Major Gifts Officer Wellington Power Corporation The Edna G. and Larry Abelson and Dolores M. Vitvitsky Mellon Financial Services UPMC Facilities Stacy Hoffman, Administrative Coordinator Barbara A. and M. Alfred Seltman, DMD, Cynthia D. Warsing Edward Milstein UPMC Prehospital Care Kambra McConnel, Major Gifts Officer ______Medical Research Fund Jefferson A. Whalen Mitchell Modell UPMC Sports Medicine Norma J. McGowan, Manager FOUNDATIONS The Deno F. Barsotti Family Fund Michael B. Wrobleski Molto Bella Ceramica Peter J. Weidhorn Jennifer Zazzera, Administrative Coordinator The Calihan Fund Dr. Antonio Moretti The Wheeler Family UPMC Cancer Centers and the University of Pittsburgh Cancer Jennifer Zgurich, Major Gifts Officer The Nancy T. and William S. Conover Fund ______Mosaic Media Group Jeffrey Williamson Institute gratefully acknowledge the foundations that have provided The PNC Foundation IN-KIND DONATIONS Mike Moulton Wyndham Garden Hotel, University Place support of $250 or more to further our mission. ______The Larry Potter Memorial Fund Nemacolin Woodlands Resort Mark Yannazzio UPMC Cancer Centers and the University of Pittsburgh Cancer UPMC CANCER CENTERS AND The Orris C. Hirtzel and Beatrice Dewey Hirtzel Jonathan Newman Yellowstone Club Alex Leona Robinson Family Foundation Institute gratefully acknowledge the following donors who have provided UPCI DEVELOPMENT COMMITTEE Memorial Foundation Notre Dame Anna L. Caplan and Irene V. Caplan Endowment Fund in-kind donations valued at $500 or more to further our mission. The Tippins Foundation Oxford Development William E. Kassling, Chair, Board Chairman AXA Foundation, Inc. WABTEC Corporation Wachovia Foundation Brian Pavlet Boston Red Sox Foundation All in Good Taste Productions, Bob Sendall Wal-Mart Foundation Matt Perachi Every gift to UPMC Cancer Richard A. Cohen, President Buffalo Bills Alumni Foundation, Inc. Allegheny County Police - Superintendant Charles Moffat David Perkins H. Mak, Inc. Cancer Foundation for Melanoma Research Allegheny Golf Cart Rental - Jodi Voloskie Centers and the University of ______Michael Pitak DSF Charitable Foundation Anonymous Pittsburgh Cancer Institute plays a Thomas Flannery, Managing Director UNITED WAY Pitt Ohio Express Boyden Emma Clyde Hodge Memorial Fund Aramark vital role in advancing research and Pittsburgh Brewing Company Equitable Resources Foundation, Inc. Donors that designated United Way donations and/or pledges of Dick Barton Kimberly Fleming, President Pittsburgh Penguins enhancing patient care. Unfortun- Fannie Mae Foundation $250 or more in support of UPMC Cancer Centers or University Beckwith Machinery Company Hefren-Tillotson, Inc. Pittsburgh Steelers ately, space is too limited to list G. C. Murphy Company Foundation of Pittsburgh Cancer Institute agency codes during the 2005 Rebecca J. Beward Barney C. Guttman, President PNC Park @ North Shore Gott Family Foundation United Way Campaign (June 2005 through April 30, 2006). BR Cohn Winery the individual names of donors Barney C. Guttman and Associates, Inc. Power Systems Division Sky Wealth Management Grant Channell Memorial Fund Charles Krug Winery that gave gifts at levels of $1 to Renaissance Pittsburgh Hotel Grow For Life Breast Cancer Foundation Ronald W. Allen City of Pittsburgh Bureau of Police Ronald B. Herberman, MD, Director Sylvia and Donald Robinson $249. Please know your support is Highmark Foundation Anonymous (6) — Chief Dominic J. Costa UPMC Cancer Centers and UPCI Sedona Rouge Hotel & Spa Hillman Foundation Richard C. Belasco City of Pittsburgh Emergency Services truly appreciated. Staley Communications Inc. Barry Lembersky, MD, Clinical Associate Professor of Medicine Howard Heinz Endowment Terry Colin Budd City of Pittsburgh Police Department UPMC Cancer Centers and UPCI Edward Staros Jewish Healthcare Foundation of Pittsburgh Lynn E. Chiafullo City of Pittsburgh Department of Public Safety If we have made an error in any STAT MedEvac Myles D. Sampson, Chairman and CEO Jonathan M. Harris Foundation Molly Ann Crooks Wendy Clubin Steve Schwartz Associates, Inc. name or omitted anyone from this Rimco Properties, Inc. Joseph E. Lavine Foundation Debra and William S. Demchak Barbara Ann and Robert A. Crown SYSCO Food Services of Pittsburgh Kennametal Foundation Alan H. Finegold Digital Visions, Pittsburgh list, please accept our apologies Thomas L. VanKirk, Esq., Managing Director Robert Timins Buchanan Ingersoll PC Multiple Myeloma Research Foundation George H. Fish Dreadnought Wines LTD and notify us at 412-623-4700. Tri-State Parking Company National Hockey League Foundation Kim H. and Curtis D. Fleming Embassy Coach Transportation Services Debi Wheeler, Community Leader Uniforms USA, Howard Elinoff Nina Baldwin Fisher Foundation Bruce R. Fonzi Brian Erinworth Wheeler Brothers, Inc. Norman Family Charitable Foundation Jack S. Goldsmith Ex Cellars Pittsburgh Life Sciences Greenhouse Delphine L. Griffin Florida Marlins Rauch Foundation Lisa Hardy Frederick Frank S & T Charitable Foundation Diane Patricia Holder Floyd Ganassi Jr. Seasons of Hope Largest Fundraiser Ever for Hillman Cancer Center Shadyside Hospital Foundation Bram B. Johnson The Forbes Family Shawn Gaertner Foundation William R. Johnson Phil Green Sherman Family Foundation Mary Lee Jordan Garry Grelick Susan G. Komen Breast Cancer Foundation Russell Kenny Lisa Hardy Talbott Lea Simonds Foundation Inc. Debra E. Lamberson Moet Hennessy USA The Alpert Family Foundation Susan Marie Lapenta Steve Herforth and Peter Karlovich The Audrey Hillman Fisher Foundation, Inc. Nancy J. and Stanley Lehman Henry Hillman, Jr. The Bryant and Nancy Yunker Foundation, Inc. Jeffrey M. Lipton Holiday Valley The Ellison Medical Foundation Jeremy L. Martin Sy Holzer The Foster Charitable Trust Sherry Miller George Huber - UPMC The Frank E. Rath * Spang and Co. Charitable Trust Theresa Whiteside Nimick, MD Fire Chief Michael H. Huss The Giant Eagle Foundation Robert F. Patton Joseph Phelps Vineyards The Hawksglen Foundation Larry E. Phillips Christopher H. Koch The Henry L. Hillman Foundation Gregory Ross Claude and Laura Kronk The Hillman Cancer Center’s annual gala, held May 3 at the UPMC Sports Performance Complex on Pittsburgh’s South Side, generated $8.2 million The Herbert G. Feldman Charitable Foundation Bruce J. Schramm Stephen Lai, PhD, MD in sponsorships and contributions for patient care and cancer research. This included $2 million from The Arnold D. Palmer Charitable Trust for a The Juliet Lea Hillman Simonds Foundation, Inc. Karen L. Shaffer Larrimor’s new initiative in cancer prevention; $1 million from Sandra and Tom Usher to support melanoma research; $1 million from the Hillman Foundations The Lee Family Foundation - Ilda and Charles Lee Jill M. Siegfried, PhD Lendable Linens to fund innovative cancer research; and $1 million in an unrestricted grant from the PNC Financial Services Group. The event was hosted by hon - The Lilah Hilliard Fisher Foundation, Inc. Patrick M. Stabile Lin Design - Theresa Lin orary celebrity chair Arnold Palmer, honorary chairs Elsie and Henry Hillman, and event co-chairs Sharon and Jim Rohr and Sandra and Tom Usher. The highlight of the evening was a surprise performance by Broadway icon Liza Minnelli.

24 UPMC Cancer Centers University of Pittsburgh Cancer Institute 25 2006 ASCO Highlights UPMC and Lilly Oncology Partner for Awareness

Researchers from the University of Pittsburgh School of UPMC and Lilly Oncology recently collaborated to bring two unique cancer awareness Medicine presented findings from more than 30 studies at programs to the Pittsburgh area. Oncology on Canvas: Expressions of a Woman's the American Society of Clinical Oncology’s annual meeting Cancer Journey is a worldwide traveling art in Atlanta. Presentation highlights included an evaluation of exhibit that focuses on the millions of people the impact of race and income on women’s experiences with affected by women's cancers and raises aware - metastatic breast cancer. The study led by Margaret Quinn ness of the benefits of art therapy as a means of Rosenzweig, PhD, looked at how women perceived barriers coping with cancer. Cancer patients, family, to treatment and symptom management by evaluating the friends, and health care providers from 23 coun - experiences of 57 women who were subdivided according to tries created the more than 400 pieces of artwork varied groupings of race and income. Researchers found that low-income African that make up the exhibit. Selections from the exhibit American women were more likely to report physical and social distress and uncertainty were displayed at Hillman Cancer Center; UPMC Cancer Center, Upper about their future than other groups evaluated in the study. Results revealed the crucial St. Clair; UPMC Cancer Center, Steubenville; and UPMC|Jameson influence health care providers can have on improving outcomes for patients by tailoring Cancer Center throughout August and September. Lilly also part - care more appropriately to provide women with the tools they need to better cope with nered with UPMC to present a special A Reason to Hope lecture advanced breast cancer. featuring DeeDee Jonrowe, breast cancer survivor and Iditarod competitor. Ms. Jonrowe shared her journey as a breast In a study of a new chemotherapy drug for liver cancer, researchers found that the devel - cancer survivor, her lifestyle as a kennel owner and trainer, her 24 years opment of a skin rash correlated directly with the patient’s response to treatment. The of racing in the Alaskan Iditarod, and the encouraging promise of improved study included 57 patients with advanced liver, gallbladder, and bile duct cancers who cancer treatments at community lectures in Pittsburgh and Greensburg were not candidates for surgery and who were treated with lapatinib. Upon evaluating its toxic effects in patients, researchers found that 20 patients developed a skin rash from lapatinib. Patients who developed the rash lived for an average of 10 months compared Remembering Mayor O'Connor to five months for those who did not develop a rash. According to Ramesh K. Ramanathan, UPMC Cancer Centers and the University of Pittsburgh Cancer Institute join the City of MD, the study has implications for predicting growth of cancer and could be a method to Pittsburgh and the western Pennsylvania region in mourning the death of Mayor Bob identify patients with advanced cancer who would most likely respond to this treatment. O'Connor of complications from primary central nervous system lymphoma. A memorial Suresh Ramalingam, MD, received a Clinical Research Development Award for a study fund has been established in Mr. O'Connor's honor to support lymphoma research. on vorinostat, one of a class of drugs called histone deacetylases, thought to stop the Contributions can be sent to UPCI Development Department, UPMC Cancer Pavilion, Suite growth of tumor cells by altering the expression of genes necessary for cancer cell 1B, 5150 Centre Ave., Pittsburgh, 15232. Checks should be made payable to UPCI and growth. In the study, Dr. Ramalingam examined the effects of three different doses of include Mr. O'Connor's name in the memo line. For more information, call 412-623-4700. vorinostat on patients with head and neck cancer, bladder cancer, and mesothelioma to see how safely it could be added to standard chemotherapy. Eleven out of 28 patients Preclinical Gene Therapy Advances in Ovarian Cancer had a partial response to treatment, and the disease was stabilized in an additional seven patients. David L. Bartlett, MD, chief, Division of Surgical Oncology, and a team of researchers reported promising results that may lead to advances in the treatment of ovarian cancer at Potential New Treatment for Breast Cancer the American Society of Gene Therapy annual meeting. The team inoculated mice with an ovarian cancer cell line, treating some immediately with Victor G. Vogel, MD, MHS, director, Magee-Womens Breast Cancer Program of UPMC a genetically engineered vaccine containing a gene that induces cell death, or apoptosis. Cancer Centers, and colleagues from the National Surgical Adjuvant Breast and Bowel Treatment was delayed 30 to 60 days in another group of mice and withheld entirely in Project found that the osteoporosis drug raloxifene was equally effective in reducing the control mice. Immediate treatment completely prevented tumor growth in 90 percent of the risk of breast cancer as the breast cancer treatment drug tamoxifen, according to a study mice, and delayed treatment significantly inhibited tumor growth. These promising pre - published in the June 21 issue of the Journal of the American Medical Association . clinical results may soon be translated into a clinical trial for women with recurrent Compared to tamoxifen, raloxifene also was safer in terms of causing fewer uterine can - ovarian cancer. cers and blood clots. Raloxifene and tamoxifen are both effective in reducing the risk of invasive breast cancer but each has potential disease and quality of life side effects that women and their physicians need to consider, according to Dr. Vogel.

26 UPMC Cancer Centers NONPROFIT ORG U.S. POSTAGE PAID PITTSBURGH, PA DISCOVERY & CARE PERMIT NO. 3834

A publication of UPMC Cancer Centers and the University of Pittsburgh Cancer Institute

UPMC Cancer Pavilion 5150 Centre Ave. Pittsburgh, PA 15232 1-800-533-UPMC (8762) www.UPMCCancerCenters.com

UPMC Cancer Centers offers cancer patients excep - tional care and innovative treatments close to home. Working in tandem with the University of Pittsburgh Cancer Institute, western Pennsylvania’s only National Cancer Institute- designated Comprehensive Cancer Center, UPMC Cancer Centers provides the latest advances in cancer prevention, detection, diagnosis, and treatment at community-based locations throughout the region. The University of Pittsburgh Cancer Institute comprises the academic and research activities for cancer at the University of Pittsburgh and the University of Pittsburgh Medical Center.

For information about supporting cancer research efforts and patient care at the University of Pittsburgh Cancer Institute and UPMC Cancer Centers, contact us at 412-623-4700.

UPMC Cancer Centers and University of Pittsburgh Cancer Institute