Mouse Anti-Human Serum Amyloid a Monoclonal Antibody, Clone 4I84 (DCABH-6007) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

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Mouse Anti-Human Serum Amyloid A Monoclonal Antibody, clone 4I84 (DCABH-6007) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Specificity Recognize human SAA1. Do not recognize human SAA2, human SAA4, feline, canine, equine or bovine SAA. Immunogen Human serum amyloid A (SAA) Isotype IgG1 Source/Host Mouse Species Reactivity Human Clone 4I84 Purity Protein G purified Purification Purity≥ 95 % Conjugate Unconjugated Applications ELISA(Cap), ELISA(Det), LFIA We recommend the following for sandwich ELISA (Capture - Detection): DMAB8184 - DCABH-6007; DMAB8186 - DCABH-6007; DCABH-6007 - CABT-54364MH; CABT-54364MH - DCABH-6007 Epitope Recognizes aa 64-71 but also reacts with aa 28-38 indicating that the epitope may be partly conformational. Format Liquid Concentration Lot specific Size 1 mg Buffer 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative. Preservative 0.095% sodium azide Storage Store at 2-8℃. 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Ship Wet ice Warnings This product is for research use only and is not intended for diagnostic use. BACKGROUND Introduction Serum amyloid A (SAA) proteins are a family of apolipoproteins associated with high-density lipoprotein (HDL) in plasma. Different isoforms of SAA are expressed constitutively (constitutive SAAs) at different levels or in response to inflammatory stimuli (acute phase SAAs). These proteins are produced predominantly by the liver. The conservation of these proteins throughout invertebrates and vertebrates suggests that SAAs play a highly essential role in all animals. Keywords SAA1;serum amyloid A1;SAA;PIG4;SAA2;TP53I4 GENE INFORMATION Gene Name SAA1 Entrez Gene ID 6288 UniProt ID P0DJI8 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.

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Influence of Serum Amyloid a (SAA1) And
Influence of Serum Amyloid A (SAA1) and SAA2 Gene Polymorphisms on Renal Amyloidosis, and on SAA/ C-Reactive Protein Values in Patients with Familial Mediterranean Fever in the Turkish Population AYSIN BAKKALOGLU, ALI DUZOVA, SEZA OZEN, BANU BALCI, NESRIN BESBAS, REZAN TOPALOGLU, FATIH OZALTIN, and ENGIN YILMAZ ABSTRACT. Objective. To evaluate the effect of serum amyloid A (SAA) 1 and SAA2 gene polymorphisms on SAA levels and renal amyloidosis in Turkish patients with familial Mediterranean fever (FMF). Methods. SAA1 and SAA2 gene polymorphisms and SAA levels were determined in 74 patients with FMF (39 female, 35 male; median age 11.5 yrs, range 1.0–23.0). All patients were on colchicine therapy. SAA1 and SAA2 gene polymorphisms were analyzed using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). SAA and C-reactive protein (CRP) values were measured and SAA/CRP values were calculated. Results. The median SAA level was 75 ng/ml (range 10.2–1500). SAA1 gene polymorphisms were: α/α genotype in 23 patients (31.1%), α/ß genotype in 30 patients (40.5%), α/γ genotype in one patient (1.4 %), ß/ß genotype in 14 patients (18.9%), ß/γ genotype in 5 patients (6.8 %), and γ/γ geno- type in one patient (1.4%). Of the 23 patients who had α/α genotype for the SAA1 polymorphism, 7 patients had developed renal amyloidosis (30.4%) compared to only one patient without this geno- type (1/51; 2.0%); p < 0.001. SAA2 had no effect on renal amyloidosis. SAA1 and SAA2 genotypes had no significant effect on SAA levels.
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Transposable Elements As Sensors of SARS-Cov-2 Infection
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