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(12) United States Patent (10) Patent No.: US 7,662,389 B2 Clark Et Al

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(12) United States Patent (10) Patent No.: US 7,662,389 B2 Clark Et Al USOO7662389B2 (12) United States Patent (10) Patent No.: US 7,662,389 B2 Clark et al. (45) Date of Patent: Feb. 16, 2010 (54) USE OF SERUM AMYLOIDA GENE IN Cotton et al., Proc. Natl. Acad. Sci. USA 85.4397 (1988): “Reactivity DAGNOSIS AND TREATMENT OF of cytosine and thymine in single-base-pair mismatches with GLAUCOMIA AND IDENTIFICATION OF hydroxylamine and osmium tetroxide and its application to the study ANT-GLAUCOMAAGENTS of mutations'. Cotton, Mutat. Res. 285:125-144 (1993); "Current methods of muta tion detection'. (75) Inventors: Abbot F. Clark, Arlington, TX (US); Croninet al., Human Mutation 7:244-255 (1996); "Cystic Fibrosis Wan-Heng Wang, Grapevine, TX (US); Mutation Detection by Hybridization to Light-Generated DNA Loretta Graves McNatt, Hurst, TX Probe Arrays”. (US) Ermilov et al. 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A6 IK 39/00 (2006.01) Hayashi, Genet. Anal. Tech. Appl. 9:73-79 (1992); "PCR-SSCP: A (52) U.S. Cl. ........................................ 424/184.1: 514/2 Method for Detection of Mutations'. (58) Field of Classification Search ........... ... None He, R. Sang H. Ye, RD, Serum Amyloid A induces IL-8 secretion See application file for complete search history. through a G protein-coupled receptor, FPRL1/LXA4R. Blood 101: 1572-1581 (2003). (56) References Cited Hsu et al., Carcinogenesis 15:1657-1662(1994): “Detection of DNA point mutations with DNA mismatch repair enzymes'. U.S. PATENT DOCUMENTS Krasnov et al. (Jan.-Mar. 1996); Vestn Oftalmol. “Morphological features of senile and secondary amyloidosis of the iris and Sclera in 4,656,127 A 4, 1987 Mundy patients with glaucoma' abstract with article will be in Russian 4,998,617 A 3/1991 Ladd, Jr. et al. 12(1):24-6. 5,459,039 A 10, 1995 Modrich et al. Kumon, Y. et al. 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