October 31, 2006 ͉ vol. 103 ͉ no. 44 ͉ 16059–16616

Proceedings of the National Academy ofPNAS Sciences of the United States of America www.pnas.org Cover image: Male dung beetle (Onthophagus rangifer) with branched “horns.” Beetles of this genus produce a diversity of weapons, which aid males in battles over mating opportunities with females. Females often mate with multiple males, and sperm must compete to fertilize eggs. Male beetles therefore face a trade-off between allocation of resources to horns or to testes, and this trade-off has influenced the long-term evolution of these beetles. See the article by Simmons and Emlen on pages 16346–16351. Image courtesy of Olga Helmy (University of Montana, Missoula, MT) and Douglas Emlen. From the Cover

16346 Evolutionary trade-off of weapons and testes 16068 Honey bee behavioral genomics 16079 Formaldehyde roaming mechanism 16254 Transcriptional oscillations and phenotypes 16364 Stability of inbred laboratory mice

Contents INAUGURAL ARTICLE 16068 Genomic dissection of behavioral maturation in the honey bee Charles W. Whitfield, Yehuda Ben-Shahar, Charles Brillet, THIS WEEK IN PNAS Isabelle Leoncini, Didier Crauser, Yves LeConte, Sandra Rodriguez-Zas, and Gene E. Robinson ➜ See Profile on page 16065 16059 In This Issue PHYSICAL SCIENCES

COMMENTARIES APPLIED PHYSICAL SCIENCES 16076 Acceleration of the recognition rate between grafted ligands and receptors with magnetic forces 16061 Skirting the transition state, a new paradigm in reaction J. Baudry, C. Rouzeau, C. Goubault, C. Robic, rate theory L. Cohen-Tannoudji, A. Koenig, E. Bertrand, Joel M. Bowman and J. Bibette ➜ See companion article on page 16079 CHEMISTRY 16063 Discovery of principles of nature from mathematical modeling of DNA microarray data 16079 Photodissociation of acetaldehyde as a second example of the roaming mechanism Orly Alter ➜ See companion article on page 16254 P. L. Houston and S. H. Kable ➜ See Commentary on page 16061 16083 Folding of the C-terminal bacterial binding domain in statherin upon adsorption onto hydroxyapatite crystals PROFILE Gil Goobes, Rivka Goobes, Ora Schueler-Furman, David Baker, Patrick S. Stayton, and Gary P. Drobny 16065 Profile of Gene E. Robinson 16089 The limitations on organic detection in Mars-like soils by Nick Zagorski thermal volatilization–gas chromatography–MS and their ➜ See Inaugural Article on page 16068 implications for the Viking results Rafael Navarro-Gonza´lez, Karina F. Navarro, Jose´ de la Rosa, Enrique In˜iguez, Paola Molina, Luis D. Miranda, Pedro Morales, Edith Cienfuegos, Patrice Coll, Franc¸ois Raulin, Freely available online through the PNAS open access option. Ricardo Amils, and Christopher P. McKay

PNAS ͉ October 31, 2006 ͉ vol. 103 ͉ no. 44 ͉ iii–xii Downloaded by guest on September 26, 2021 ENGINEERING 16159 Different modes of SecY–SecA interactions revealed 16095 Anisotropic mechanosensing by mesenchymal stem cells by site-directed in vivo photo-cross-linking Kyle Kurpinski, Julia Chu, Craig Hashi, and Song Li Hiroyuki Mori and Koreaki Ito 16165 Enzyme–microbe synergy during cellulose hydrolysis PHYSICS by Clostridium thermocellum 16101 Liquid–crystalline aqueous clay suspensions Yanpin Lu, Yi-Heng Percival Zhang, and Lee R. Lynd Laurent J. Michot, Isabelle Bihannic, Solange Maddi, Se´rgio S. Funari, Christophe Baravian, 16170 Definition of the mitochondrial proteome Pierre Levitz, and Patrick Davidson by measurement of molecular masses of membrane proteins 16105 Breaking resolution limits in ultrafast electron Joe Carroll, Ian M. Fearnley, and John E. Walker diffraction and microscopy Peter Baum and Ahmed H. Zewail 16176 Independent and simultaneous translocation of two substrates by a nucleotide sugar transporter SUSTAINABILITY SCIENCE Carolina E. Caffaro, Carlos B. Hirschberg, and Patricia M. Berninsone 16111 Exploring the engine of anthropogenic iron cycles Daniel B. Mu¨ller, Tao Wang, Benjamin Duval, 16182 Complement activation by photooxidation and T. E. Graedel products of A2E, a lipofuscin constituent of the retinal pigment epithelium BIOLOGICAL SCIENCES Jilin Zhou, Young Pyo Jang, So Ra Kim, and Janet R. Sparrow

APPLIED BIOLOGICAL SCIENCES 16188 Impaired nucleotide excision repair upon macrophage differentiation is corrected 16095 Anisotropic mechanosensing by mesenchymal stem cells by E1 ubiquitin-activating enzyme Kyle Kurpinski, Julia Chu, Craig Hashi, and Song Li Thierry Nouspikel and Philip C. Hanawalt

BIOCHEMISTRY BIOPHYSICS 16117 Identification of conserved lipid͞detergent-binding sites 16076 Acceleration of the recognition rate between grafted in a high-resolution structure of the membrane protein ligands and receptors with magnetic forces cytochrome c oxidase J. Baudry, C. Rouzeau, C. Goubault, C. Robic, Ling Qin, Carrie Hiser, Anne Mulichak, R. Michael Garavito, L. Cohen-Tannoudji, A. Koenig, E. Bertrand, and Shelagh Ferguson-Miller and J. Bibette 16123 Crystal structure of a photoactivated deprotonated intermediate of rhodopsin 16083 Folding of the C-terminal bacterial binding domain in David Salom, David T. Lodowski, Ronald E. Stenkamp, statherin upon adsorption onto hydroxyapatite crystals Isolde Le Trong, Marcin Golczak, Beata Jastrzebska, Gil Goobes, Rivka Goobes, Ora Schueler-Furman, Tim Harris, Juan A. Ballesteros, and Krzysztof Palczewski David Baker, Patrick S. Stayton, and Gary P. Drobny 16129 Three strategically placed hydrogen-bonding residues 16194 Structural and dynamical changes in an ␣-subunit of a convert a proton pump into a sensory receptor heterotrimeric G protein along the activation pathway Yuki Sudo and John L. Spudich Ned Van Eps, William M. Oldham, Heidi E. Hamm, and Wayne L. Hubbell 16135 Identification of a histidine-tyrosine cross-link in the active site of the cbb3-type cytochrome c oxidase 16200 On structural transitions, thermodynamic equilibrium, from Rhodobacter sphaeroides and the phase diagram of DNA and RNA duplexes Virve Rauhama¨ki, Marc Baumann, Rabah Soliymani, under torque and tension Anne Puustinen, and Mårten Wikstro¨m Jeff Wereszczynski and Ioan Andricioaei 16141 Reaction mechanism of guanidinoacetate 16206 Monitoring intermediate filament assembly by methyltransferase, concerted or step-wise small-angle x-ray scattering reveals the molecular Xiaodong Zhang and Thomas C. Bruice architecture of assembly intermediates 16147 Functional reconstitution and characterization Anna V. Sokolova, Laurent Kreplak, Tatjana Wedig, of Pyrococcus furiosus RNase P Norbert Mu¨cke, Dmitri I. Svergun, Harald Herrmann, Hsin-Yue Tsai, Dileep K. Pulukkunat, Walter K. Ueli Aebi, and Sergei V. Strelkov Woznick, and Venkat Gopalan 16212 Structure of electron transfer flavoprotein-ubiquinone 16153 Isoelectric focusing technology quantifies protein oxidoreductase and electron transfer to the signaling in 25 cells mitochondrial ubiquinone pool Roger A. O’Neill, Arunashree Bhamidipati, Xiahui Bi, Jian Zhang, Frank E. Frerman, and Jung-Ja P. Kim Debabrita Deb-Basu, Linda Cahill, Jason Ferrante, Erik Gentalen, Marc Glazer, John Gossett, Kevin Hacker, 16218 Structure of phosphorylated enzyme I, the Celeste Kirby, James Knittle, Robert Loder, Catherine phosphoenolpyruvate:sugar phosphotransferase Mastroieni, Michael MacLaren, Thomas Mills, Uyen system sugar translocation signal protein Nguyen, Nineveh Parker, Audie Rice, David Roach, Alexey Teplyakov, Kap Lim, Peng-Peng Zhu, Geeta Kapadia, Daniel Suich, David Voehringer, Karl Voss, Jade Celia C. H. Chen, Jennifer Schwartz, Andrew Howard, Yang, Tom Yang, and Peter B. Vander Horn Prasad T. Reddy, Alan Peterkofsky, and Osnat Herzberg

PNAS ͉ October 31, 2006 ͉ vol. 103 ͉ no. 44 ͉ v Downloaded by guest on September 26, 2021 16224 Yeast mitochondrial ADP͞ATP carriers are monomeric 16290 Pds1͞Esp1-dependent and -independent sister in detergents chromatid separation in mutants defective Lisa Bamber, Marilyn Harding, P. Jonathan G. Butler, for protein phosphatase 2A and Edmund R. S. Kunji Xianying Tang and Yanchang Wang

16230 An approach to crystallizing proteins by synthetic 16296 The p110␣ isoform of PI3K is essential for proper growth symmetrization factor signaling and oncogenic transformation D. Rey Banatao, Duilio Cascio, Christopher S. Crowley, Jean J. Zhao, Hailing Cheng, Shidong Jia, Li Wang, Ole V. Mark R. Fleissner, Heather L. Tienson, and Todd O. Yeates Gjoerup, Aki Mikami, and Thomas M. Roberts 16236 Role of histone tails in chromatin folding revealed 16301 Stimulatory effect of voluntary exercise or fat removal by a mesoscopic oligonucleosome model (partial lipectomy) on apoptosis in the skin of UVB Gaurav Arya and Tamar Schlick light-irradiated mice 16242 Membrane-dependent oligomeric structure and pore Yao-Ping Lu, You-Rong Lou, Bonnie Nolan, Qing-Yun Peng, formation of a ␤-hairpin antimicrobial peptide in lipid Jian-Guo Xie, George C. Wagner, and Allan H. Conney bilayers from solid-state NMR Rajeswari Mani, Sarah D. Cady, Ming Tang, Alan J. DEVELOPMENTAL BIOLOGY Waring, Robert I. Lehrer, and Mei Hong 16307 Sog͞Chordin is required for ventral-to-dorsal Dpp͞BMP 16248 General structural motifs of amyloid protofilaments transport and head formation in a short germ insect Neil Ferguson, Johanna Becker, Henning Tidow, Sandra Maurijn van der Zee, Oliver Stockhammer, Tremmel, Timothy D. Sharpe, Gerd Krause, Jeremy Cornelia von Levetzow, Rodrigo Nunes Flinders, Miriana Petrovich, John Berriman, Hartmut da Fonseca, and Siegfried Roth Oschkinat, and Alan R. Fersht 16313 Jun NH2-terminal kinase (JNK) prevents nuclear ␤-catenin accumulation and regulates axis CELL BIOLOGY formation in Xenopus embryos 16254 A rapid genome-scale response of the transcriptional Guanghong Liao, Qinghua Tao, Matthew Kofron, oscillator to perturbation reveals a period-doubling Juei-Suei Chen, Aryn Schloemer, Roger J. Davis, path to phenotypic change Jen-Chih Hsieh, Chris Wylie, Janet Heasman, Caroline M. Li and Robert R. Klevecz and Chia-Yi Kuan ➜ See Commentary on page 16063 16319 Murine inner cell mass-derived lineages depend ␣ 16260 PGC-1 protects skeletal muscle from atrophy by on Sall4 function suppressing FoxO3 action and atrophy-specific Ulrich Elling, Christian Klasen, Tobias Eisenberger, gene transcription Katrin Anlag, and Mathias Treier Marco Sandri, Jiandie Lin, Christoph Handschin, Wenli Yang, Zoltan P. Arany, Stewart H. Lecker, 16325 Establishment of stable cell lines of Drosophila germ-line Alfred L. Goldberg, and Bruce M. Spiegelman stem cells Yuzo Niki, Takafumi Yamaguchi, and Anthony P. Mahowald 16266 Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch EVOLUTION Sylvie Giuriato, Sandra Ryeom, Alice C. Fan, Pavan 16331 Ancient polymorphism and functional variation Bachireddy, Ryan C. Lynch, Matthew J. Rioth, Jan in the primate MHC-DQA1 5؅ cis-regulatory region van Riggelen, Andrew M. Kopelman, Emmanuelle Dagan A. Loisel, Matthew V. Rockman, Gregory A. Passegue´, Flora Tang, Judah Folkman, Wray, Jeanne Altmann, and Susan C. Alberts and Dean W. Felsher

16272 Regulation of the SUMO pathway sensitizes 16337 Evolution of complexity in signaling pathways differentiating human endometrial stromal Orkun S. Soyer and Sebastian Bonhoeffer cells to progesterone Marius C. Jones, Luca Fusi, Jenny H. Higham, Hany 16343 Good genes sexual selection in nature Abdel-Hafiz, Kathryn B. Horwitz, Eric W.-F. Lam, John A. Byers and Lisette Waits and Jan J. Brosens 16346 Evolutionary trade-off between weapons and testes 16278 Macrophage inhibitory cytokine 1 mediates a Leigh W. Simmons and Douglas J. Emlen p53-dependent protective arrest in S phase in response to starvation for DNA precursors 16352 Genome scan for cis-regulatory DNA motifs associated Mukesh K. Agarwal, Kedar Hastak, Mark W. Jackson, with social behavior in honey bees Samuel N. Breit, George R. Stark, and Munna L. Agarwal Saurabh Sinha, Xu Ling, Charles W. Whitfield, Chengxiang Zhai, and Gene E. Robinson 16284 ␤-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes GENETICS Keshava Rajagopal, Erin J. Whalen, Jonathan D. 16358 Caspar, a suppressor of antibacterial immunity Violin, Jonathan A. Stiber, Paul B. Rosenberg, in Drosophila Richard T. Premont, Thomas M. Coffman, Myungjin Kim, Jun Hee Lee, Soo Young Lee, Eunhee Kim, Howard A. Rockman, and Robert J. Lefkowitz and Jongkyeong Chung

PNAS ͉ October 31, 2006 ͉ vol. 103 ͉ no. 44 ͉ vii Downloaded by guest on September 26, 2021 16364 Stability of inbred mouse strain differences in behavior MEDICAL SCIENCES and brain size between laboratories and across decades 16436 Radiolabeled somatostatin receptor antagonists are Douglas Wahlsten, Alexander Bachmanov, Deborah A. Finn, preferable to agonists for in vivo peptide receptor and John C. Crabbe targeting of tumors Mihaela Ginj, Hanwen Zhang, Beatrice Waser, Renzo 16370 Induction and repair of zinc-finger nuclease-targeted Cescato, Damian Wild, Xuejuan Wang, Judit Erchegyi, double-strand breaks in Caenorhabditis elegans Jean Rivier, Helmut R. Ma¨cke, and Jean Claude Reubi somatic cells Jason Morton, M. Wayne Davis, Erik M. Jorgensen, 16442 Thrombocytopenia and kidney disease in mice with and Dana Carroll a mutation in the C1galt1 gene Warren S. Alexander, Elizabeth M. Viney, Jian-Guo Zhang, 16376 Ubiquitin-associated domain of Mex67 synchronizes Donald Metcalf, Maria Kauppi, Craig D. Hyland, Marina R. recruitment of the mRNA export machinery Carpinelli, William Stevenson, Ben A. Croker, Adrienne A. with transcription Hilton, Sarah Ellis, Carly Selan, Harshal H. Nandurkar, Carole Gwizdek, Nahid Iglesias, Manuel S. Rodriguez, Christopher C. Goodnow, Benjamin T. Kile, Nicos A. Batool Ossareh-Nazari, Maria Hobeika, Gilles Divita, Nicola, Andrew W. Roberts, and Douglas J. Hilton Franc¸oise Stutz, and Catherine Dargemont 16448 RIG-G as a key mediator of the antiproliferative activity 16382 Hypersensitivity to oxygen and shortened lifespan of interferon-related pathways through enhancing p21 in a Drosophila mitochondrial complex II mutant and p27 proteins David W. Walker, Petr Ha´jek, Julien Muffat, Dan Knoepfle, Shu Xiao, Dong Li, Hai-Qing Zhu, Man-Gen Song, Stephanie Cornelison, Giuseppe Attardi, and Seymour Benzer Xiao-Rong Pan, Pei-Min Jia, Lin-Ling Peng, Ai-Xia Dou, Guo-Qiang Chen, Sai-Juan Chen, Zhu Chen, IMMUNOLOGY and Jian-Hua Tong 16388 Differential requirement for Lck during primary and memory CD8؉ T cell responses 16454 Saturated fatty acids inhibit induction of insulin gene Kavita Tewari, Jane Walent, John Svaren, Rose transcription by JNK-mediated phosphorylation Zamoyska, and M. Suresh of insulin-receptor substrates Giovanni Solinas, Willscott Naugler, Francesco 16394 Role of ABCC1 in export of sphingosine-1-phosphate Galimi, Myung-Shik Lee, and Michael Karin from mast cells Poulami Mitra, Carole A. Oskeritzian, Shawn G. Payne, 16460 Enforced expression of the homeobox gene Mixl1 Michael A. Beaven, Sheldon Milstien, and Sarah Spiegel impairs hematopoietic differentiation and results in acute myeloid leukemia 16400 Modeling CTLA4-linked autoimmunity with Stefan Glaser, Donald Metcalf, Li Wu, Adam H. Hart, RNA interference in mice Ladina DiRago, Sandra Mifsud, Angela D’Amico, Zhibin Chen, John Stockton, Diane Mathis, Samantha Dagger, Chiara Campo, Angela C. Chan, and Christophe Benoist David J. Izon, and Lorraine Robb

16406 Complete correction of murine Artemis 16466 Angiogenesis-independent tumor growth mediated immunodeficiency by lentiviral by stem-like cancer cells vector-mediated gene transfer Per Ø. Sakariassen, Lars Prestegarden, Jian Wang, Kai-Ove Gustavo Mostoslavsky, Attila J. Fabian, Sean Rooney, Skaftnesmo, Rupavathana Mahesparan, Carla Molthoff, Frederick W. Alt, and Richard C. Mulligan Peter Sminia, Eirik Sundlisæter, Anjan Misra, Berit Bølge Tysnes, Martha Chekenya, Hans Peters, Gabriel Lende, 16412 Structural basis for recognition of the nonclassical Karl Henning Kalland, Anne M. Øyan, Kjell Petersen, MHC molecule HLA-G by the leukocyte Ig-like Inge Jonassen, Albert van der Kogel, Burt G. ͞ ͞ ͞ receptor B2 (LILRB2 LIR2 ILT4 CD85d) Feuerstein, A. Jorge A. Terzis, Rolf Bjerkvig, Mitsunori Shiroishi, Kimiko Kuroki, Linda Rasubala, and Per Øyvind Enger Kouhei Tsumoto, Izumi Kumagai, Eiji Kurimoto, Koichi Kato, Daisuke Kohda, and Katsumi Maenaka 16472 The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal 16418 A central regulatory role for eosinophils and the fibroblasts and ovarian tumorigenesis ͞ eotaxin CCR3 axis in chronic experimental allergic Gong Yang, Daniel G. Rosen, Zhihong Zhang, Robert C. airway inflammation Bast, Jr., Gordon B. Mills, Justin A. Colacino, Imelda Patricia C. Fulkerson, Christine A. Fischetti, Melissa L. Mercado-Uribe, and Jinsong Liu McBride, Lynn M. Hassman, Simon P. Hogan, and Marc E. Rothenberg MICROBIOLOGY 16424 Rel͞NF-␬B double mutants reveal that cellular immunity 16478 Terminal organelle development in the cell wall-less is central to Drosophila host defense bacterium Mycoplasma pneumoniae Nina Matova and Kathryn V. Anderson Benjamin M. Hasselbring, Jarrat L. Jordan, Robert W. Krause, and Duncan C. Krause 16430 Proinsulin is encoded by an RNA splice variant in human blood myeloid cells 16484 Cryo-EM visualization of transfer messenger RNA with Parth Narendran, Alana M. Neale, Bo Han Lee, Katrina Ngui, two SmpBs in a stalled ribosome Raymond J. Steptoe, Grant Morahan, Ole Madsen, James A. Sukhjit Kaur, Reynald Gillet, Wen Li, Richard Gursky, Dromey, Kent P. Jensen, and Leonard C. Harrison and Joachim Frank

PNAS ͉ October 31, 2006 ͉ vol. 103 ͉ no. 44 ͉ ix Downloaded by guest on September 26, 2021 16490 Secretion signal recognition by YscN, the Yersinia 16568 Flavonoid fisetin promotes ERK-dependent long-term type III secretion ATPase potentiation and enhances memory Joseph A. Sorg, Bill Blaylock, and Olaf Schneewind Pamela Maher, Tatsuhiro Akaishi, and Kazuho Abe

16496 Mammalian reovirus, a nonfusogenic nonenveloped PHYSIOLOGY virus, forms size-selective pores in a model membrane Melina A. Agosto, Tijana Ivanovic, and Max L. Nibert 16574 Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during ␤1-adrenergic regulation 16502 The pathogen-associated iroA gene cluster mediates Joanne T. Hulme, Ruth E. Westenbroek, Todd Scheuer, bacterial evasion of lipocalin 2 and William A. Catterall Michael A. Fischbach, Hening Lin, Lu Zhou, Yang Yu, Rebecca J. Abergel, David R. Liu, Kenneth N. Raymond, 16580 Urocortin 2 modulates glucose utilization and insulin Barry L. Wanner, Roland K. Strong, Christopher T. Walsh, sensitivity in skeletal muscle Alan Aderem, and Kelly D. Smith Alon Chen, Bhawanjit Brar, Cheol Soo Choi, David Rousso, Joan Vaughan, Yael Kuperman, Shee Ne Kim, 16508 Establishment of a Nipah virus rescue system Cindy Donaldson, Sean M. Smith, Pauline Jamieson, Misako Yoneda, Vanessa Guillaume, Fusako Ikeda, Chien Li, Tim R. Nagy, Gerald I. Shulman, Yuki Sakuma, Hiroki Sato, T. Fabian Wild, Kuo-Fen Lee, and Wylie Vale and Chieko Kai 16586 A common mechanism underlies stretch activation and 16514 A B lymphocyte mitogen is a Brucella abortus virulence receptor activation of TRPC6 channels factor required for persistent infection Maria A. Spassova, Thamara Hewavitharana, Wen Xu, Juan Manuel Spera, Juan Esteban Ugalde, Juan Mucci, Jonathan Soboloff, and Donald L. Gill Diego J. Comerci, and Rodolfo Augusto Ugalde

PLANT BIOLOGY NEUROSCIENCE 16592 The gene responsible for borate cross-linking of pectin 16520 Cdc42 deficiency causes Sonic hedgehog-independent Rhamnogalacturonan-II is required for plant reproductive holoprosencephaly tissue development and fertilization Lei Chen, Guanghong Liao, Linda Yang, Kenneth Campbell, Hiroaki Iwai, Akiko Hokura, Masahiro Oishi, Hiroshi Chida, Masato Nakafuku, Chia-Yi Kuan, and Yi Zheng Tadashi Ishii, Shingo Sakai, and Shinobu Satoh

16526 A homeostatic rule for inhibitory synapses promotes 16598 Roles of Arabidopsis ATP͞ADP isopentenyltransferases temporal sharpening and cortical reorganization and tRNA isopentenyltransferases in Samat B. Moldakarimov, James L. McClelland, cytokinin biosynthesis and G. Bard Ermentrout Kaori Miyawaki, Petr Tarkowski, Miho Matsumoto-Kitano, Tomohiko Kato, Shusei Sato, Danuse Tarkowska, Satoshi 16532 A peptide zipcode sufficient for anterograde transport Tabata, Go¨ran Sandberg, and Tatsuo Kakimoto within amyloid precursor protein Prasanna Satpute-Krishnan, Joseph A. DeGiorgis, Michael P. Conley, Marcus Jang, and Elaine L. Bearer POPULATION BIOLOGY 16068 Genomic dissection of behavioral maturation in the 16538 Pheromone reception in fruit flies expressing a moth’s honey bee odorant receptor Charles W. Whitfield, Yehuda Ben-Shahar, Charles Brillet, Zainulabeuddin Syed, Yuko Ishida, Katherine Taylor, Isabelle Leoncini, Didier Crauser, Yves LeConte, Deborah A. Kimbrell, and Walter S. Leal Sandra Rodriguez-Zas, and Gene E. Robinson ➜ See Profile on page 16065 16544 Tactile guidance of prey capture in Etruscan shrews 16604 Evaluation of mortality trajectories Farzana Anjum, Hendrik Turni, Paul G. H. Mulder, in evolutionary biodemography Johannes van der Burg, and Michael Brecht Stephan B. Munch and Marc Mangel

16550 Somatomotor and oculomotor inferior olivary neurons have distinct electrophysiological phenotypes Francisco J. Urbano, John I. Simpson, and Rodolfo R. Llina´s SOCIAL SCIENCES

16556 Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines ENVIRONMENTAL SCIENCES Xiang-ming Zha, John A. Wemmie, Steven H. Green, 16604 Evaluation of mortality trajectories and Michael J. Welsh in evolutionary biodemography Stephan B. Munch and Marc Mangel 16562 Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses Anita Scheuber, Rachel Rudge, Lydia Danglot, PSYCHOLOGY Graca Raposo, Thomas Binz, Jean-Christophe 16608 Universality of color names Poncer, and Thierry Galli Delwin T. Lindsey and Angela M. Brown

PNAS ͉ October 31, 2006 ͉ vol. 103 ͉ no. 44 ͉ xi Downloaded by guest on September 26, 2021 MEDICAL SCIENCES CORRECTIONS 16614 Bim and Bad mediate imatinib-induced killing of Bcr͞Abl؉ leukemic cells, and resistance due to CHEMISTRY their loss is overcome by a BH3 mimetic Junya Kuroda, Hamsa Puthalakath, Mark S. Cragg, Priscilla 16614 Tetrahedral structure or chains for liquid water N. Kelly, Philippe Bouillet, David C. S. Huang, Shinya Teresa Head-Gordon and Margaret E. Johnson Kimura, Oliver G. Ottmann, Brian J. Druker, Andreas Villunger, Andrew W. Roberts, and Andreas Strasser APPLIED BIOLOGICAL SCIENCES 16614 Adeno-associated virus serotype 9 vectors MICROBIOLOGY transduce murine alveolar and nasal 16615 Leishmania disease development depends on the epithelia and can be readministered presence of apoptotic promastigotes in the Maria P. Limberis and James M. Wilson virulent inoculum Ger van Zandbergen, Annalena Bollinger, Alexander GENETICS Wenzel, Shaden Kamhawi, Reinhard Voll, Matthias 16614 A high-throughput gene knockout procedure for Klinger, Antje Mu¨ller, Christoph Ho¨lscher, Martin Neurospora reveals functions for multiple Herrmann, David Sacks, Werner Solbach, transcription factors and Tama´s Laskay Hildur V. Colot, Gyungsoon Park, Gloria E. Turner, Carol Ringelberg, Christopher M. Crew, Liubov xiii–xv Author Index Litvinkova, Richard L. Weiss, Katherine A. Borkovich, and Jay C. Dunlap xvi Subscription Form

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