2018 Progress Report and 2019 Update
2018 Progress Report and 2019 Update Defeat GBM Research Collaborative Key Personnel: PRINCIPAL INVESTIGATORS • Tim Cloughesy, MD A NOTE FROM THE CEO University of California, Los Angeles • John de Groot, MD MD Anderson Cancer Center Over the past five years, the Defeat GBM Research Collaborative has stood as a testament to the power of ideas, collaboration, and the philanthropic partnership • Frank Furnari, PhD between patient advocacy nonprofits like NBTS and a dedicated community of Ludwig Cancer Research, supporters. University of California, San Diego • Dimpy Koul, PhD When we launched Defeat GBM as our flagship research initiative in 2014, we MD Anderson Cancer Center sought to do something different. Decades of grant-making in the traditional form of funding separate, individual research projects (one- to two-year grants • Ingo Mellinghoff, MD to a single Principle Investigator) had produced extraordinary knowledge of the Memorial Sloan Kettering Cancer Center biology of glioblastoma cells, but not nearly enough of this work was primed to • Paul Mischel, MD move out of research laboratories and into clinical trials for patients. Ludwig Cancer Research, University of California, San Diego NBTS wanted to see what could be accomplished if, instead of continuing this traditional model of research funding, we deep-funded a team of expert • Erik Sulman, MD, PhD researchers, over a five-year period, to work collaboratively. This team would be NYU Langone’s Perlmutter charged with working across the continuum of research to translate a scientific Cancer Center discovery into an actionable treatment strategy and/or medical product that could • Roel Verhaak, PhD be tested in clinical trials, and hopefully become an approved new therapeutic The Jackson Laboratory option for patients.
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