Ludwig Presence at 2016 AACR Annual Meeting

Ludwig Scientist (s) Affiliation (s) Session Time Location Session Type Session Title Presentation/Abstract Title & Time

SATURDAY, APRIL 16

Using Tumor Biology to Drive Room 288, Morial Convention 9:30am - 9:55am: Immunotherapies for Sarcoma: Crystal Mackall Ludwig Stanford 8:00am - 10:00am Educational Session More Effective Sarcoma Center Progress and Challenges Therapy

Room 278, Morial Convention for the Crystal Mackall Ludwig Stanford 10:15am -12:15pm Educational Session 10:15am - 12:15pm: Education Manuscript Center Non-Immunologist: Tutorial

SUNDAY, APRIL 17

Ovarian cancer Room 343, Morial Convention Meet-the-Expert George Coukos Ludwig Lausanne 7:00am - 8:00am immunotherapy. From bench Invited speaker Center Session to bedside Cellular Plasticity, Cellular Room 288, Morial Convention Meet-the-Expert Xin Lu Ludwig Oxford 7:00am - 8:00am Heterogeneity and Single Cell Invited speaker Center Session Sequencing Stapled Peptides as a New Room 357, Morial Convention Meet-the-Expert Form of Medicine for Ludwig New York 7:00am - 8:00am Invited speaker Center Session Oncology Targets: Challenges and Progress Room 271, Morial Convention Meet-the-Expert The Role of Metabolism in Matthew Vander Heiden Ludwig MIT 7:00am - 8:00am Invited speaker Center Session Supporting Tumor Growth Thirteenth Annual AACR Award for Lifetime Bob Weinberg Ludwig MIT 8:15am - 9:00am Hall F, Morial Convention Center Awards and Lectures Award recipient Achievement in Cancer Research Thirty-Sixth Annual AACR New Orleans Theater A, Morial Award for Outstanding Award recipient. Presentation title: Biology and Franziska Michor Ludwig Harvard 1:00pm - 2:00pm Awards and Lectures Convention Center Achievement in Cancer dynamics of cancer evolution Research Checkpoint blockade therapy is improved by altering the immune suppressive Olivier De Henau,* Taha Ludwig MSK 1:00pm - 5:00pm Section 26, poster board 15 Poster Session Immune Modulating Agents 1 microenvironment with IPI-549, a potent and Merghoub, Jedd Wolchok selective inhibitor of PI3K-gamma, in preclinical models Mechanisms of Novel refinements for the autochthonous mouse Tyler Jacks** Ludwig MIT 1:00pm - 5:00pm Section 30, poster board 8 Poster Session Tumorigenesis in Animal model of cancer Models of Cancer 1

*denotes scientist is lead author **denotes scientist is senior author 1 Ludwig Presence at 2016 AACR Annual Meeting

Ming Zhang, Nicholas Roberts, Christine Joseph, Maria The genomic landscapes of inflammatory bowel Popoli,Kenneth Kinzler, Bert Ludwig Johns Hopkins 1:00pm - 5:00pm Section 5, poster board 11 Poster Session Genomic Profiling of disease-associated colorectal cancers Vogelstein, Nickolas Papadopoulos** Mitochondrial perturbations as a novel approach Anthony Letai** Ludwig Harvard 1:00pm - 5:00pm Section 20, poster board 24 Poster Session Biomarkers to personalized medicine

Pregnancy associated plasma protein A (PAPP- Crystal Mackall** Ludwig Stanford 1:00pm - 5:00pm Section 27, poster board 2 Poster Session Therapeutic Antibodies A) is a potential novel therapeutic target in Ewing sarcoma

Implications of Akt inhibition for neoadjuvant Fernanda Koyama*, Anamaria Ludwig 1:00pm - 5:00pm Section 19, poster board 22 Poster Session PI3K/AKT Inhibitors radiotherapy: improving the rectal cancer Camargo** treatment Genetic Determinants and Excessive HCK kinase activity in the tumor Matthias Ernst* Ludwig Melbourne 1:00pm - 5:00pm Section 25, poster board 13 Poster Session Regulators of Cancer stroma promotes progression Immunity Genetic Determinants and Identify and prioritize candidate neoantigens from Luis Diaz Ludwig Johns Hopkins 1:00pm - 5:00pm Section 25, poster board 5 Poster Session Regulators of Cancer cancer exome sequencing with unmatched Immunity accuracy Checkpoint blockade therapy is improved by altering the immune suppressive Olivier De Henau,* Taha Ludwig MSK 1:00pm - 5:00pm Section 26, poster board 15 Poster Session Immune Modulating Agents 1 microenvironment with IPI-549, a potent and Merghoub, Jedd Wolchok selective inhibitor of PI3K-gamma, in preclinical models 3:15pm - 3:35pm: A phase I study of an HLA- La Nouvelle Orleans Ballroom, Clinical Trials Plenary Immuno-oncology Clinical Pierre van der Bruggen Ludwig 2:15pm - 4:15pm DPB1*0401-restricted T-cell receptor targeting Morial Convention Center Session Trials I MAGE-A3 for patients with metastatic cancer

AACR-Bayard D. Clarkson Room 393, Morial Convention 2:55pm - 3:20pm: Normal and neoplastic stem Irv Weissman Ludwig Stanford 2:15pm - 4:00pm Major Symposium Symposium: Tumor Cell of Center cells Origin and Cancer Stem Cells

2:00pm - 4:15pm: Durable, long-term survival in La Nouvelle Orleans Ballroom, Clinical Trials Plenary Immuno-oncology Clinical previously treated patients with advanced Stephen Hodi* Ludwig Harvard 2:15pm - 4:15pm Morial Convention Center Session Trials I (MEL) who received nivolumab (NIVO) monotherapy in a phase I trial 2:00pm - 4:15pm: Initial report of overall survival rates from a randomized phase II trial evaluating Michael Postow,* Jedd Wolchok, Ludwig MSK; Ludwig La Nouvelle Orleans Ballroom, Clinical Trials Plenary Immuno-oncology Clinical 2:15pm - 4:15pm the combination of nivolumab (NIVO) and Stephen Hodi** Harvard Morial Convention Center Session Trials I ipilimumab (IPI) in patients with advanced melanoma (MEL) Inflammation and Cancer: Room 293, Morial Convention 2:55pm - 3:20pm: Deciphering mechanisms of Johanna Joyce Ludwig Lausanne 2:15pm - 4:00pm Major Symposium Targeting the Myeloid Center resistance to macrophage-targeted therapies Microenvironment

*denotes scientist is lead author **denotes scientist is senior author 2 Ludwig Presence at 2016 AACR Annual Meeting

2:55pm - 3:20pm: Co-targeting epigenetic New Orleans Theater A, Morial Epigenetics and Signaling in Karen Chichowski (Chairperson) Ludwig Harvard 2:15pm - 4:00pm Major Symposium regulators and oncogenic signaling pathways in Convention Center Cancer cancer

Room 288, Morial Convention 2:25pm - 2:50pm: Stem cells and signaling Philip Beachy Ludwig Stanford 2:15pm - 4:00pm Major Symposium Developmental Pathways Center pathways in regeneration and

Disordered Gene Regulation 4:35pm - 4:50pm: TMPRSS2-ERG drives global Room 343, Morial Convention Cigall Kadoch** Ludwig Harvard 4:15pm - 6:15pm Minisymposium and Chromatin State in mistargeting of mammalian SWI/SNF (BAF) Center Malignant Transformation complexes in prostate cancer

5:05pm - 5:20pm: Obesity-induced inflammation Joao Incio,* Keehoon Jung, Dai Room 288, Morial Convention Highlights in Cancer Ludwig Harvard 4:15pm - 6:15pm Minisymposium and desmoplasia promote pancreatic cancer Fukumura, Rakesh Jain** Center Prevention Advances progression and resistance to chemotherapy

Tumor Microenvironment Mardi Gras Ballroom D-E, New 6:15pm - 6:30pm - Chariperson elect: Remarks; Johanna Joyce Ludwig Lausanne 6:00pm - 8:00pm Town Meeting Working Group (TME) Town Orleans Marriott 7:30pm - 7:35pm - Closing Remarks Hall Meeting and Reception

AACR Pediatric Cancer Grand Salon B, Hilton New Working Group Town Hall Crystal Mackall Ludwig Stanford 6:30pm - 9:30pm Town Meeting 6:40pm - 7:30pm: Panelist Orleans Riverside Meeting and Networking Reception

MONDAY, APRIL 18

Ya-Fang Chang,* Yuhao Wang, Targeting nuclear receptors and their Ludwig 8:00am - 12:00pm Section 17, poster board 13 Poster Session Novel Molecular Targets Geoffrey Greene** coregulators in triple-negative Discovery and preclinical development of a highly Mersana Therapeutics: Growth Factor Receptors and potent NaPi2b-targeted antibody-drug conjugate research conducted with 8:00am -12:00pm Section 15, poster board 3 Poster Session Surface Antigens as (ADC) with significant activity in patient-derived Ludwig licensed Therapeutic Targets non-small cell (NSCLC) xenograft technology models

A phase I, open-label study of GSK3174998 Phase I Clinical Trials in administered alone and in combination with Stephen Hodi Ludwig Harvard 8:00am -12:00pm Section 13 Poster Session Progress pembrolizumab in patients (pts) with selected advanced solid tumors (ENGAGE-1)

Surojit Sur,* Yuan Qiao, Anja PRINT: A protein bioconjugation method with Fries, Kenneth Kinzler, Bert Ludwig Johns Hopkins 8:00am - 12:00pm Section 19, poster board 30 Poster Session Drug Delivery 1 exquisite N-terminal specificity Vogelstein, Shibin Zhou**

Surojit Sur,* Kenneth Kinzler, PRINT: A protein bioconjugation method with Ludwig Johns Hopkins 8:00am - 12:00pm Section 19, poster board 30 Poster Session Drug Delivery 1 , Shibin Zhou** exquisite N-terminal specificity

*denotes scientist is lead author **denotes scientist is senior author 3 Ludwig Presence at 2016 AACR Annual Meeting

Discovery of new AML and MDS patient subsets sensitive to the highly selective RARα agonist SY- Ravindra Majeti Ludwig Stanford 8:00am - 12:00pm Section 14, poster board 7 Poster Session Differentiation Therapy 1425 (tamibarotene) through super-enhancer analysis

Immune Microenvironment IL-18 is associated with the onset and Matthias Ernst Ludwig Melbourne 8:00am - 12:00pm Section 24, poster board 4 Poster Session and Antitumor Immunity progression of gastric cancer

Genomic Insights Into 11:30am -11:55am: Noninvasive lymphoma Room 288, Morial Convention Recent Advances in Ash Alizadeh Ludwig Stanford 10:30am - 12:15pm Lymphoma Pathogenesis, genotyping and personalized monitoring using Center Organ Site Research Diagnosis, and Treatment circulating DNA

SY35. Addressing the 11:10am -11:35am: Combinations using New Orleans Theater C, Morial Mechanisms of Resistance Jedd Wolchok Ludwig MSK 10:30am - 12:15pm Major Symposium checkpoint blockade as one means to address Convention Center and Lack of Response in resistance Cancer Immunotherapy

Attenuated oncolytic virus HSV1716 increases in Crystal Mackall** Ludwig Stanford 1:00pm - 5:00pm Section 25, poster board 16 Poster Session Adoptive Cell Therapy vivo expansion of GD2- targeting CAR T cells in murine solid tumor models

Therapeutic Antibodies and Pilot study of DNA microseeding to activate Jedd Wolchok Ludwig MSK 1:00pm - 5:00pm Section 27, poster board 21 Poster Session Vaccines immune rejection of canine melanoma Clonal Heterogeneity and Reconstructing the evolutionary history of Bert Vogelstein Ludwig Johns Hopkins 1:00pm - 5:00pm Section 28, poster board 4 Poster Session Evolution metastatic cancers New Orleans Theater A, Morial Transcriptional Control in Mammalian SWI/SNF (BAF) complex structure Cigall Kadoch Ludwig Harvard 1:00pm - 2:45pm Major Symposium Convention Center Cancer and function in human cancer Molecular Endocrinology of Anna Dembo,* Geoffrey ER-positive breast with the use Ludwig Chicago 1:00pm - 5:00pm Section 1, poster board 6 Poster Session Hormone-dependent Greene** of hormone replacement therapy 1:00pm - 5:00pm: Pilot study of DNA Therapeutic Antibodies and Jedd Wolchok Ludwig MSK 1:00pm - 5:00pm Section 27, poster board 21 Poster Session microseeding to activate immune rejection of Vaccines canine melanoma 3:20pm - 3:35pm: Loss of SIRT6 reactivates the Room 393, Morial Convention Epigenetic Alterations in Sridhar Ramaswamy Ludwig Harvard 3:00pm - 5:00pm Minisymposium oncofetal RNA-binding protein Lin28b to drive Center Cancer pancreatic cancer Robert Nakayama,* Robert Williams, Seth Cassel, 3:50pm - 4:05pm: Genome-wide mistargeting of Room 393, Morial Convention Epigenetic Alterations in Mingxiang Teng, Rafael Irizarry, Ludwig Harvard 3:00pm - 5:00pm Minisymposium oncogenic SWI/SNF(BAF) complexes in Center Cancer George Demetri, Cigall SMARCB1(BAF47)-deficient sarcomas Kadoch** 3:05pm - 3:20pm: Chimeric antigen receptor T- New Orleans Theater B, Morial Immunotherapy Trial Results cell therapy against anaplastic lymphoma kinase Crystal Mackall Ludwig Stanford 3:00pm - 5:00pm Minisymposium Convention Center and Correlates (ALK) is limited by target antigen density and CAR surface expression

*denotes scientist is lead author **denotes scientist is senior author 4 Ludwig Presence at 2016 AACR Annual Meeting

AACR Radiation Science and Grand Salon A, Hilton New Medicine Working Group Ralph Weichselbaum Ludwig Chicago 5:00pm - 7:00pm Town Meeting Invited speaker Orleans Riverside Town Hall Meeting and Networking Reception

New Orleans Theater C, Morial Should Tumor Heterogeneity Kornelia Polyak (Chairperson) Ludwig Harvard 5:00pm - 6:30pm Forum Chairperson Convention Center Guide Therapy?

TUESDAY, APRIL 19

Room 393, Morial Convention Meet-the-Expert Cancer Immunotherapy: Of Jedd Wolchok Ludwig MSK 7:00am - 8:00am Invited speaker Center Session Mice and Men (and Dogs)

Room 271, Morial Convention Meet-the-Expert Immunotherapy for Childhood Crystal Mackall Ludwig Stanford 7:00am - 8:00am Invited speaker Center Session Malignancies Mouse Models to Define Room 354, Morial Convention Meet-the-Expert Michael Hemann Ludwig MIT 7:00am - 8:00am Mechanisms of Drug Invited speaker Center Session Resistance Cell Cycle Control and Joan Brugge Ludwig Harvard 8:00am - 12:00pm Section 2, poster board 24 Poster Session Regulation of cytokinesis by polo-like kinase 4 Checkpoints Late-Breaking Wenxin Zheng,* Kinga Skowron, Research: Clinical Radiotherapy sensitizes pancreatic cancer to Ainhoa Arina, Hua Liang, Ralph Ludwig Chicago 8:00am -12:00pm Section 12 Late-Breaking Poster Session Research 2 / immunotherapy by promoting infiltration Weichselbaum** Endocrinology INCAGN01949: an anti-OX40 agonist antibody Taha Merghoub, Daniel Ludwig MSK; Ludwig with the potential to enhance tumor-specific T-cell Hirschhorn-Cymerman, Gerd 8:00am - 12:00pm Section 25, poster board 1 Poster Session Immune Checkpoints 2 New York responsiveness, while selectively depleting Ritter, Jedd Wolchok intratumoral regulatory T cells

Structural and Chemical Stapled peptide inhibitors of the estrogen Sean Fanning, Geoffrey Greene Ludwig Chicago 8:00am - 12:00pm Section 20, poster board 17 Poster Session Biology receptor/steroid receptor coactivator interaction Genes associated with neuronal development, Yevgenia Khodor,* Daisy Transcriptional Regulation including splicing regulatory factors, increase in Riquelme, Frank Gertler, Ludwig MIT 8:00am - 12:00pm Section 8, poster board 9 Poster Session and Gene Expression in expression across epithelial-mesenchymal Christopher Burge** Human Malignancies transition INCAGN01949: an anti-OX40 agonist antibody Taha Merghoub, Gerd Ritter, Ludwig MSK; Ludwig with the potential to enhance tumor-specific T-cell 8:00am -12:00pm Section 25, poster board 1 Poster Session Immune Checkpoints 2 Jedd Wolchok New York responsiveness, while selectively depleting intratumoral regulatory T cells

Taha Merghoub, Sadna Budha, Ludwig MSK; Ludwig A novel agonist antibody (INCAGN01876) that Roberta Zappasodi, Gerd Ritter, 8:00am -12:00pm Section 25, poster board 17 Poster Session Immune Checkpoints 3 New York targets the costimulatory receptor GITR Jedd Wolchok Survivin-mediated radio-sensitization response in Ralph Weichselbaum Ludwig Chicago 8:00am - 12:00pm Section 18, poster board 3 Poster Session Preclinical Radiotherapeutics mutant tumor cells

*denotes scientist is lead author **denotes scientist is senior author 5 Ludwig Presence at 2016 AACR Annual Meeting

Tumor associated macrophages in Sushama Varma, Robert Molecular Classification and Ludwig Stanford 8:00am - 12:00pm Section 23, poster board 19 Poster Session undifferentiated uterine sarcoma: association with Sweeney, Matt van de Rijn Genomic Applications angiogenesis and therapeutic implications A first-in-human phase I dose escalation study of Alexander Lesokhin, Alexandra Room 391, Morial Convention Clinical Trials Plenary Immuno-oncology Clinical Ludwig MSK 10:30am -12:15pm the OX40 agonist MOXR0916 in patients with Snyder Center Session Trials II refractory solid tumors Rational combination of targeted agents and BH3 Anthony Letai** Ludwig Harvard 1:00pm - 5:00pm Section 2, poster board 1 Poster Session Cell Death 1 mimetics to improve cancer treatment New Orleans Theater B, Morial Tumor Evolution Within the 1:40pm - 2:05pm: Immune-related changes in Kornelia Polyak (Chairperson) Ludwig Harvard 1:00pm - 2:45pm Major Symposium Convention Center Host Microenvironment breast tumor evolution New Orleans Theater B, Morial Tumor Evolution Within the 1:10pm - 1:35pm: Analysis of clonal populations Joan Brugge Ludwig Harvard 1:00pm - 2:45pm Major Symposium Convention Center Host Microenvironment derived from breast and ovarian tumors

Keehoon Jung, Takahiro Heishi, Targeting the immune microenvironment to Molecular and Cellular Andy Yun, Timothy Padera, Ludwig Harvard 1:00pm - 5:00pm Section 33, poster board 3 Poster Session improve colorectal cancer anti-angiogenic Imaging of Cancer 1 Rakesh Jain, Dai Fukumura therapy

Association of the G/G-SNP309 variant in the Tumor Suppressors: TP53 Elisabeth Bond, Gareth Bond Ludwig Oxford 1:00pm - 5:00pm Section 9, poster board 18 Poster Session mdm2 gene with earlier tumor onset in female Pathway renal cell carcinoma patients Targeting Protein Kinases, Design of effective combination therapies for high- Ioannis Zervantonakis, Joan Ludwig Harvard 1:00pm - 5:00pm Section 19, poster board 5 Poster Session Death Pathways, and the grade serous ovarian cancer using patient- Brugge** Tumor Microenvironment derived xenograft models Late-Breaking Poster Late-Breaking Research: Landscape of tumor-infiltrating T-cell repertoire of Stephen Hodi Ludwig Harvard 1:00pm - 5:00pm Section 10 Session Tumor Biology 3 human cancers Recurrent gains of CD274 (PD-L1) and Mechanisms and Applications PDCD1LG2 (PD-L2) provide a genetic basis for Stephen Hodi Ludwig Harvard 1:00pm - 5:00pm Section 27, poster board 10 Poster Session of Immune-based Therapies PD-1 ligand expression in a subset of solid tumors The anti-CD47 antibody Hu5F9-G4 activates Jens-Peter Volkmer, Kevin Kao, Immune Modulation from Non- macrophages and inhibits ovarian cancer Ludwig Stanford 1:00pm - 5:00pm Section 26, poster board 10 Poster Session Aditi Bellary, Irv Weissman Immunotherapy: Preclinical xenografts, alone and in combination with chemotherapy or immunotherapy Rapid 5-marker multiplex phenotyping of breast Circulating Biomarkers 3 / Stephen Kron Ludwig Chicago 1:00pm - 5:00pm Section 23, poster board 9 Poster Session cancer subtypes & tumor-infiltrating leukocytes Immune Biomarkers “in situ” in FFPE sections Margaret Hoang, Aviv Regev Ludwig Johns Hopkins; Room 354, Morial Convention SY28. Population Genetics Accumulation of somatic mutations in normal and (Chairperson) 1:00pm - 2:45pm Major Symposium Ludwig MIT Center Meets Single Cell Analysis cancerous tissues with age

DNA damage and tumour burden in mouse colon is increased in response to carcinogen exposure Chemical and Viral Matthias Ernst Ludwig Melbourne 1:00pm - 5:00pm Section 28, poster board 14 Poster Session after induction of chronic inflammation - a more disease relevant model of colitis-associated colorectal cancer?

*denotes scientist is lead author **denotes scientist is senior author 6 Ludwig Presence at 2016 AACR Annual Meeting

Bjarne Bartlett, Maria Popoli, Circulating Biomarkers 3 / Optimized plasma collection procedures for liquid Ludwig Johns Hopkins 1:00pm - 5:00pm Section 23: poster board 17 Poster Session Luis Diaz** Immune Biomarkers biopsy analyses in cancer Early Clinical Trials 3:30pm - 3:45pm: Association of programmed Room 343, Morial Convention Clinical Trials Evaluating Cell-based, death-ligand 1 (PD-L1) and 2 (PD-L2) expression Stephen Hodi** Ludwig Harvard 3:00pm - 5:00pm Center Minisymposium Checkpoint Inhibitors, and with nivolumab (NIVO) efficacy in advanced Novel Immunotherapeutics melanoma (MEL) Dissecting the multicellular ecosystem of Ludwig MIT; Ludwig New Orleans Theater A, Morial New "Cool Tools" for Cancer Aviv Regev, Levi Garraway** 3:00pm - 5:00pm Minisymposium metastatic melanoma by single-cell RNA- Harvard Convention Center Discovery sequencing Genomic Alterations and Ludwig Harvard; Ludwig Room 265, Morial Convention Accelerating prediction of tumor vulnerabilities Levi Garraway, Calvin Kuo 3:00pm - 5:00pm Minisymposium Their Functional Stanford Center using next-generation cancer models Consequences Identifying Targets and New Orleans Theater B, Morial Neutralization of BCL2/XL enhances the Joan Brugge** Ludwig Harvard 3:00pm - 5:00pm Minisymposium Combinations through Novel Convention Center cytotoxicity of T-DM1 in vivo Approaches

Room 293, Morial Convention Genotype Versus Phenotype Anthony Letai Ludwig Harvard 5:00pm - 6:30pm Forum Invited speaker Center for Patient Selection

WEDNESDAY, APRIL 20

Room 393, Morial Convention Meet-the-Expert Engineering the Cancer Tyler Jacks Ludwig MIT 7:00am - 8:00am Invited speaker Center Session Genome

Zohreh Amoozgar,* Jonas Dual inhibition of Ang-2 and VEGF receptors Late-Breaking Poster Late-Breaking Research: Kloepper, Meenal Datta, Ludwig Harvard 8:00am - 12:00pm Section 11 normalizes tumor vasculature and prolongs Session Tumor Biology 4 Keehoon Jung survival in by altering macrophages

Jonas Kloepper,* Zohreh Ang-2/VEGF bispecific antibody reprograms Amoozgar, Meenal Datta, Late-Breaking Poster Late-Breaking Research: Ludwig Harvard 8:00am - 12:00pm Section 11 macrophages and resident microglia to anti-tumor Keehoon Jung, Dai Fukumura, Session Tumor Biology 4 phenotype and prolongs glioblastoma survival Rakesh Jain** Pfizer; iTeos PF-06840003: a highly selective IDO-1 inhibitor Therapeutics: research 8:00am - 12:00pm Section 22, poster board 4 Poster Session Immune Modulating Agents 2 that shows good in vivo efficacy in combination conducted with Ludwig with immune checkpoint inhibitors licensed technology

BET bromodomain degradation as a therapeutic James Bradner Ludwig Harvard 8:00am - 12:00pm Section 16, poster board 24 Poster Session Epigenetic Agents strategy in drug-resistant multiple myeloma

Immune Modulation from Non- Gerd Ritter, Taha Merghoub, Ludwig New York; AGEN1884 and AGEN2041: Two functionally 8:00am - 12:00pm Section 26; poster board 29 Poster Session Immunotherapy and Jedd Wolchok Ludwig MSK distinct anti-CTLA-4 antagonist antibodies Antibodies: Clinical

New Bioinformatic Tools, Fast and accurate fusion transcript detection Aviv Regev Ludwig MIT 8:00am - 12:00pm Section 37, poster board 3 Poster Session Databases, Portals, and Data using the Trinity Cancer Transcriptome Analysis Resources Toolkit

*denotes scientist is lead author **denotes scientist is senior author 7 Ludwig Presence at 2016 AACR Annual Meeting

BET bromodomain degradation as a therapeutic James Bradner Ludwig Harvard 8:00am - 12:00pm Section 16, poster board 24 Poster Session Epigenetic Agents strategy in drug-resistant multiple myeloma Immune Modulation from Non- Gerd Ritter, Taha Merghoub, Ludwig New York; AGEN1884 and AGEN2041: Two functionally 8:00am - 12:00pm Section 26, poster board 29 Poster Session Immunotherapy and Jedd Wolchok Ludwig MSK distinct anti-CTLA-4 antagonist antibodies Antibodies: Clinical Immune Modulation from Non- Toxicity profile of contemporaneous PD-1 Stephen Hodi Ludwig Harvard 8:00am - 12:00pm Section 26, poster board 13 Poster Session Immunotherapy and inhibitor immunotherapy and radiotherapy Antibodies: Clinical Bazedoxifene inhibits ESR1 somatic mutants with Sean Fanning,* David Hosfield, Ludwig Chicago 8:00am - 12:00pm Section 21, poster board 19 Poster Session Drug Design improved potency compared to tamoxifene and Geoffrey Greene** raloxifene Cellular and Molecular Mena at the nexus of chemotaxis and haptotaxis Frank Gertler** Ludwig MIT 8:00am - 12:00pm Section 29, poster board 3 Poster Session Dynamics of Cancer during tumor progression Migration and Invasion

Detection and Monitoring of La Nouvelle Orleans Ballroom, 7:45am - 8:10am: Liquid biopsies and the early Luis Diaz Ludwig Johns Hopkins 7:45am - 9:30am Plenary session Pre-Malignant Disease and Morial Convention Center diagnosis of cancer Therapeutic Response

Room 343, Morial Convention Precision Cancer Medicine 10:25am - 10:50am: Precision cancer medicine Anthony Letai (Chairperson) Ludwig Harvard 10:15am - 12:00pm Major Symposium Center Using Functional Testing using BH3 profiling

Function of T Cells and Their Alexander Rudensky New Orleans Theater B, Morial 10:55am - 11:20am: Function of regulatory T Ludwig MSK 10:15am -12:00pm Major Symposium Therapeutic Application in (Chairperson) Convention Center cells in cancer Cancer

*denotes scientist is lead author **denotes scientist is senior author 8