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Impacting Healthcare a Conference Hosted By Personalized Medicine: Impacting Healthcare A Conference Hosted By November 17-18, 2010 Joseph B. Martin Conference Center at Harvard Medical School, Boston 6th Annual Conference CONFERENCE PROGRAM www.personalizedmedicineconference.org HIGHLIGHTS FROM PAST CONFERENCES November 17, 2010 Dear Colleague, Welcome to the 2010 Personalized Medicine Conference. We and the other members of the Conference Organizing Committee, whose names you will see on the last page of this program, are pleased to offer this sixth annual gathering co-hosted by Partners HealthCare, Harvard Medical School and Harvard Business School. We offer our profound thanks to the speakers, the panelists, the staff and our generous sponsors for their essential contributions. This is a time of active and vigorous conversation at many different levels about the state and future of healthcare. Invariably, those conversations recognize the extraordinary advances in knowledge and technological resources that have taken place in recent years. They also recognize the enticing opportunities for medical practice to implement the principles of personalized medicine into routine practice. Many examples can be cited in which those opportunities have been realized and are being applied daily. At the same time, there are those who contend that personalized medicine is a concept whose aspiration may far exceed its ultimate reality. In the context of those differing opinions the annual Personalized Medicine Conference seeks to engage a diverse audience of national and international thought leaders in discussions that will advance the understanding of and commitment to how the promise of personalized medicine is being and may be further fulfilled. As you will see from this year’s program, we have sought to give attention both to accomplishments that have been made and to challenges to be overcome. We invite your active participation in these discussions. We are pleased to have our ongoing collaboration with the Personalized Medicine Coalition whose help brings added value in organizing and presenting the meeting. Sincerely, Scott T. Weiss, M.D., M.S. Raju Kucherlapati, Ph.D Scientific Director, Paul C. Cabot Professor of Genetics and Partners HealthCare Center for Professor of Medicine, Harvard Medical School; Personalized Genetic Medicine; Chair, Conference Organizing Committee Professor of Medicine, Harvard Medical School 3 Thanks to Our Sponsors This conference is organized by the Partners HealthCare Center for Personalized Genetic Medicine and Harvard Business School in collaboration with the Personalized Medicine Coalition. It is made possible by the generous support of our sponsors. SIGNATURE PLATINUM GOLD 4 SILVER BRONZE CONTRIBUTING SPONSOR 5 Conference Program Wednesday, November 17, 2010 7:15 a.m. Registration & Continental Breakfast 8:15 a.m. Welcome Raju Kucherlapati, Ph.D. Paul C. Cabot Professor of Genetics, Professor of Medicine, Harvard Medical School Opening Remarks Scott Weiss, M.D., M.S. Scientific Director, Partners HealthCare Center for Personalized Genetic Medicine, Associate Director, Channing Laboratory, Professor of Medicine, Harvard Medical School Elizabeth G. Nabel, M.D. President, Brigham and Women’s Hospital/Faulkner Hospital 9:00 a.m. Keynote: A Pharmaceutical Mikael Dolsten, M.D., Ph.D. Perspective President, Worldwide Research & Development, Pfizer Introducer: Deborah Dunsire, M.D. President & CEO, Millennium: The Takeda Oncology Company 9:30 a.m. Networking Break 10:15 a.m. Panel: The Cost and Value Moderator: Gregory J. Downing, D.O., Ph.D. of Personalized Medicine Senior Advisor & Director, Personalized Health Care Initiative, U.S. in the Era of Reform Department of Health and Human Services Introducer: Felix Frueh, Ph.D. VP, Personalized Medicine Research & Development, Medco Health Solutions Jane Barlow, M.D., M.P.H., M.B.A. VP, Medical Strategy & Precision Health Solutions, Medco Health Solutions Sharon Levine, M.D. Associate Executive Director, Permanente Medical Group Arnold Milstein, M.D., M.P.H. Professor of Medicine, Stanford University School of Medicine, Medical Director, Pacific Business Group on Health David Parker, Ph.D. VP, Boston Healthcare 11:20 a.m. Presentation of William S. Dalton, Ph.D., M.D. Personalized Medicine President, CEO & Center Director, Moffitt Cancer Center Coalition’s Sixth Annual Award for Leadership in Presentation: Edward Abrahams, Ph.D. Personalized Medicine President, Personalized Medicine Coalition 11:50 a.m. Luncheon 1:05 p.m. Debate: Patenting Gene Moderator: Carolyn Johnson Tests: Judge Robert Science Writer, The Boston Globe Sweet’s Decision Introducer: Kathy Giusti Association for Molecular Founder & CEO, Multiple Myeloma Research Foundation Pathology, et al. v. United States Patent and Trademark Attorney for the Plaintiffs: Office, et al. Christopher A. Hansen, Esq., Staff Attorney, ACLU Attorney for the Defendants: Jennifer Gordon, Ph.D., J.D. , Partner, Baker Botts LLP 6 Conference Program Wednesday, November 17, 2010 1:50 p.m. Keynote: An International Charles Swanton, Ph.D. Perspective Head, Translational Cancer Therapeutics Laboratory, Cancer Research UK London Research Institute Introducer: Nicholas Galakatos, Ph.D., Managing Director, Clarus Ventures 2:20 p.m. Panel: Implementation of Moderator: M. Kathleen Behrens Wilsey, Ph.D. Personalized Medicine in Founder, KEW Group Diverse Sectors Introducer: Heidi L. Rehm, Ph.D., FACMG Laboratory Director, Laboratory for Molecular Medicine, Partners HealthCare Center for Personalized Genetic Medicine, Assistant Professor of Pathology, Harvard Medical School Mark S. Boguski, M.D., Ph.D. Associate Professor, Harvard Medical School, Beth Israel Deaconess Medical Center Michael Bristow, M.D., Ph.D. Professor of Medicine, University of Colorado School of Medicine, Denver, Chief Executive Officer & President, ARCA biopharma Bruce Johnson, M.D. Director, Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Professor of Medicine, Harvard Medical School Clay Marsh, M.D. Senior Associate Vice President for Health Sciences Research, Vice Dean of Research, College of Medicine, Professor of Internal Medicine, Ohio State University 3:25 p.m. Networking Break 3:55 p.m. Panel: Molecular Moderator: Sue Siegel Diagnostics: From Partner, Mohr, Davidow Ventures Technologies to Treatments Introducer: Robert Tepper, M.D., Partner, Third Rock Ventures William Hagstrom CEO, Crescendo Bioscience K. Peter Hirth, Ph.D. Founder & CEO, Plexxikon Ryan Phelan Founder & President, DNA Direct Mark Stevenson President & CEO, Life Technologies 5:00 p.m. Keynote: An International Guilherme Suarez-Kurtz, M.D., Ph.D. Perspective Head of Pharmacology, Brazilian National Cancer Institute, Coordinator, Brazilian National Pharmacogenomics Network Introducer: Lawrence J. Lesko, Ph.D., F.C.P. Director, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration 5:30-7:00 p.m. Reception at Elements Café 7 Conference Program Thursday, November 18, 2010 7:15 a.m. Registration & Continental Breakfast 8:15 a.m. Perspectives from The U.S. Anna Barker, Ph.D. Department of Health and Former Deputy Director, National Cancer Institute; Deputy Human Services Director for Strategic Scientific Initiatives; Private Consultant Lawrence J. Lesko, Ph.D., F.C.P. Director, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration Introducer: Kristin Ciriello Pothier Vice President, Health Advances 8:55 a.m. Panel: Information Technology Moderator: Neil de Crescenzo Solutions Senior Vice President and General Manager for Health Sciences, Oracle Corp. Introducer: Richard A. Mandahl Vice President, Business Development, UNIConnect David Hickey Executive Vice President, Central Laboratory, Global Research & Development, Siemens Healthcare Diagnostics Joseph M. Jasinski, Ph.D. IBM Distinguished Engineer, Global Industry Executive, Smarter Healthcare and Life Sciences, IBM Research Emad Rizk, M.D. President, McKesson Health Solutions 10:00 a.m. Keynote: A Perspective from an William Chin, M.D. Academic Medical Center Executive Dean for Research, Harvard Medical School Introducer: Per G. H. Lofberg Executive Vice President, CVS Caremark, President, Caremark Pharmacy Services 10:30 a.m. Networking Break 10:55 a.m. Radio Broadcast: On Point Facilitator: Edward Abrahams, Ph.D. with Tom Ashbrook (off-site) President, Personalized Medicine Coalition Host: Tom Ashbrook Host & Managing Editor, On Point, WBUR, National Public Radio Guest: Margaret A. Hamburg, M.D. Commissioner of Food and Drugs, U.S. Food and Drug Administration (invited) 12:00 p.m. Bag Lunch 8 Conference Program Thursday, November 18, 2010 12:30 p.m. Keynote: FDA Perspective on Margaret A. Hamburg, M.D. Personalized Medicine Commissioner of Food and Drugs, U.S. Food and Drug Administration (invited) 1:00 p.m. National Legislative Efforts Sheila Walcoff Partner, McDermott Will & Emery Risa Stack, Ph.D. Partner, Kleiner Perkins Caufield & Byers Introducer: Gerald McDougall Partner, PricewaterhouseCoopers 1:30 p.m. Briefings: Investments in Christopher-Paul Milne, D.V.M., M.P.H., J.D. Personalized Medicine Associate Director, Tufts Center for the Study of Drug Development, Tufts University Sara Radcliffe Executive Vice President for Health, Biotechnology Industry Organization (BIO) Introducer: Jeffrey Elton, Ph.D. Chief Executive Officer, KEW Group 2:15 p.m. Interactive Case Studies on Moderators: Business Strategies for Richard Hamermesh, D.B.A. Personalized
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