R E C 0 R Still The Second Best Thing About Payday

Budding Young Scientists Aim HI H.t: 1 G H Life, Death and Everything in Between For the Stars Research Festival 12 a Big Draw By Kimberly C. Mitchell Ever heard a 10-year-old kid describe the Research Festival t was as if some giant had grabbed the NIH campus by the mechanics of jet propulsion? Or the Packs 'em In corner up near the firehouse on Old Georgetown Rd. and tilted principles behind refracted light? That's Iit so that everything slid helplessly toward the Natcher Bldg. what some Now THAT's a Oct. 6-9 as the twelfth version of Research Festival (originally youngsters Budget! only a daylong event) drew many can do after hundreds of NIH'ers to a ravishing feast spending 6 of intramural science. For a 3-day months in stretch, Natcher and its environs were to Eleven Elevate to science what Bethesda is to restaurants­ the AAAS Fellowhood Adventure a teeming smorgasbord of tasty possibili­ in Science ties. (AIS) It became almost comical, after a day or program. Get Ready for two, to see literally hundreds of pre-, Quality of Work . .... From post- and postpostdocs fleeing the , Life Week Dr. Rebecca Hackett helps a October to crowded morning plenary sessions for student prepare to measure March of one of dozens of workshops held in NASA Administrator the uptake of water and each year, various nooks and warrens within the nutrients through the root Daniel Goldin opens sprawling Natcher complex. All adopted these young session on origins of /ife. system of a plant. scientists, SEE FESTIVAL, PAGE 6 ages 8 through 15, attend Saturday sessions President Signs '99 Budget, Big Increase for NIH on such varied topics as heart function, As the Record went to press, President Clinton had just signed an SEE ADVENTURE, PAGE 8 omnibus spending bill for fiscal year 1999 that increases NIH's budget by Symposium Pays 'Glowing' Tribute 14.6 percent, or almost $2 billion. The total for NIH is $15.612 billion. A series of 6 continuing resolutions had enabled the agency to remain To Inventor Robert Bowman open during budget negotiations since Oct. 1. A more detailed budget story will appear in the Nov. 17 issue. By Deborah Noble Two and a half years after his death, Dr. SRO for Prions Robert L. Bowman, former chief of the Nobelist Prusiner Draws Homecoming Crowd NHLBI Laboratory of Technical Develop­ ifteen minutes before he was to take the podium to deliver ment, is being FNIA's annual Florence Mahoney Lecture on Aging on Oct. 14, honored for his most neurologist Dr. Stanley Prusiner, last year's winner of the Nobel influential invention, Prize for physiology or medicine, had theAMINCO­ drawn so large a crowd that people were Bowman turned away at the Masur Auditorium spectrophotofluoro­ door. meter (SPF), which U.S. Department Inside the hall, the atmosphere attained popularized UV­ of Health and the sort of warmth NIH manages maybe visible fluorometry. Human Services half a dozen times a year. Precipitating A permanent exhibit l\ational Institutes conditions include a big-name visiting Dr. Bowman in the Clinical Center of I Jealth alumnus (Prusiner was a scientist in the opened recently with a day-long sympo- heart institute from 1969 ta 1972-a sium on the instrument's modern research November 3, 1998 PHS assignment he elected "instead of legacy. SEE BOWMAN, PAGE 7 Vol. L, No. 22 Dr. Stanley Prusiner SEE PRUSINER, PAGE 4 Eleven Named AAAS Fellows Eleven NIH'ers are among the 283 scientists recently elected by their peers to the rank of fellow in the American Association for the Advancement of Science. They will receive a certificate and rosette pin at the AAAS annual meeting in Anaheim, Jan. 23, 1999. The new AAAS fellows from NIH are: Drs. George W.A. Milne, Ira Pastan and Stephen J. O'Brien of NCI; Dr. Bernard Moss, NIAID; Dr. Anil B. Mukherjee, NICHD; Drs. Martin F. Gellert and David R. Davies, NIDDK; Dr. Story C. Landis, NINDS; Dr. Enoch Gordis, NIAAA; Dr. Lawrence E. "Paperless" Council Meetings-The National Advisory Shulman, NIH/OD; and Dr. Alexa T. McCray, NLM. Dental Research Council has begun conducting paperless The AAAS, founded in 1848, is the world's largest meetings by having members refer to council materials federation of scientific and engineering societies, online, essentially eliminating 10 books containing 500 with over 282 affiliated societies and 144,000 pages of summary statements and other printed material. members. The "fellows" distinction began 124 At the meetings, each council member is supplied with a years ago in 1874, and recognizes "efforts toward Have Work­ laptop computer, part of a specially created temporary network that allows independent access to the Internet. advancing science or fostering applications that are Related Pain7 By accessing a secure Web site called the NIDR Elec­ deemed scientifically or socially distinguished." Iii Do you have work­ tronic Council Reference Page, members can retrieve the related pain in agenda, concept clearances, en bloc voting list, the NIH Health Benefits Fair, Nov. 24 your neck, Electronic Council Book, and other materials. Summary statements are also available just by clicking on the In conjunction with the 1998 Federal Employees shoulders, arms or corresponding project number from the en bloc list. The hands? Do you Health Benefits Program Open Season, which runs site also eliminates the need to mail printed materials from Monday, Nov. 9 through Monday, Dec. 14, the work in an office prior to the meeting. environment, and Retirement and Benefits Service Center is sponsoring a Health Benefits Open Season Fair. The fair will be are you between Day Care Board Seeks Nominations ages 21-657 H so held in Wilson Hall, Bldg. 1 on Tuesday, Nov. 24 you maybe Since its inception in 1992, the NIH day care from 10 a.m. to 2 p.m. Representatives from most eligible to oversight board has sought co: ensure that day care of the plans that are available to NIH employees will participate in a programs and access to day care facilities are fairly be on hand to answer questions about their 1999 study of a new administered, identify areas of employee concern benefits. Iii approach to and recommend solutions and serve as a forum for reduce symptoms discussion of NIH day care issues. and improve The board is seeking volunteers to serve for a 3- function. St udy year term. Membership is open co federal employees N I H R f 0 R a involves six visits who work on the NIH campus or off-site facilities. Published biweekly at Bethesda, Md., by the Editorial Operations to Georgetown Currently, the board meets monthly for 2 hours. Branch, Division of Public Information, for the information of University Medical Attendance at these meetings is critical. Those employees of the ::-:ational Institutes of Health, Department of Health and Human Sen•ices. The content is reprinrable without Center and is free. interested in serving may self-nominate for member­ permission. Picrures may be available on request. Use of funds for You will also ship by sending a letter cosigned by their supervisor printing this periodical has been approved by the director of the receive up to $100 to the Director, DSFM, EPS/Suite 200. Include your Office of Management and Budget through Sept. 30, 1999. name, NIH mailing address, IC, branch, section, job for participating. If NIH Record Office Phone 496-2125 interested, call title and a brief biographical sketch. Also, describe Bldg. 31, Rm. 2B03 Fax 402-1485 (202) 687-3076. why you wish to serve on the board and specify any special concerns or interests related to day care. Web address Membership is an official duty and may be in­ http://www.nih.gov/news/NIH-Record/archives.htm cluded as a noncritical element on an employee's Editor The NIH Record reserves performance plan. Members are selected to be Richard McManus the righr 10 make representative of the diverse NIH population. [email protected] corrections> changes, or Voting members may not have a financial interest in deletions in submitted Assistant Editor copy in conformity with NIH-sponsored day care, except that they may have Carla Garnett the policies of the paper a dependent enrolled in NIH day care programs. [email protected] and HHS. For more information, contact Chris Steyer, 496- 0436 or Carol Wigglesworth, 402-5913. Iii U The Record is recyclable as office white paper. NIH Marks Quality of Work Life Week t's been over a year since Secretary Shalala kicked Center and chief organizer of the fair. "It is 'Service: Ioff the HHS Quality of Work Life initiative, and The rent we pay for living on this planet.' We feel over a year since NIH sponsored a Quality of Work this quote captures the spirit of the fair and the Life (QWL) week devoted to raising awareness week." about work and family life issues. From Nov. 16- The week's other events include a simulcast of 20, the spotlight will be on work and family life Secretary Shalala's Conference on Family Friendly issues again when NIH hosts its second Quality of Work Practices on Tuesday, Nov. 17, which will be Work Life Week. shown in Bldg. 31, Con£. Rm. 7 from 9 to 11 a.m. "The purpose of the first NIH Quality of Work Representatives from NIH will be participating in Life week was to introduce the NIH QWL strategy the secretary's conference, sharing the NIH experi­ and to elevate issues that employees face trying to ence with implementing family-friendly work balance work and personal responsibilities," said practices such as alternative work schedules and Marvene Horwitz, chair of the NIH QWL commit­ flexi-place work arrangements. On Wednesday, tee. "This year, the QWL week will not only feature NIH will host a reception from 10:30 a.m. to noon activities that highlight the achievements of the past in Wilson Hall, honoring the most recent recipients year, but also will give NIH employees a chance to of the NIH QWL Award. Dr. Ruth Kirschstein, NIH learn how they can make a difference in their deputy director, will give opening remarks, and communities." refreshments will be served. Finally, on Thursday, The week will begin with a Volunteer Fair on the NIH Work and Family Life Center will com­ Monday, Nov. 16 from 10 a.m. to 2 p.m. in the memorate its 1-year anniversary by hosting an open Visitor Information Center at the Clinical Center. house from 10 a.m. to 2 p.m. The center is located Over 30 agencies will be on hand to provide in Bldg. 31, Rm. B3C15. Once again, Kirschstein information about their organizations and volunteer will speak at 11 a.m. opportunities. "We have selected a quote from For more information about the NIH Quality of Marian Wright Edelman, president of the Children's Work Life week and other QWL initiatives, visit the Defense Fund, as the fair slogan," said Corliss QWL home page at: http://wwwl.od.nih.gov/ohrm/ Taylor, director of the NIH Work and Family Life qwl/default. Ii) NTCHD deputy director Dr. Yvonne Maddox (r) gives remarks at the NIH Management Cadre Program graduation \ ceremony held at the Lawton Chiles International House on Designer Mice Offer New Look Sept. 17. Administered by the Division of Workforce At Osteoporosis Development and the leadership development committee, MCP is designed to train highly motivated NIH employees Scientists at the National Institute of currently at the GS 12, 13 or 14 level to help meet future Dental Research have produced genetically leadership staffing needs at NIH. The 18-month program engineered mice that mimic many of the provides a combination of on-the-job training, academic symptoms of human osteoporosis. The courses, and selected assignments to prepare individuals to mice are missing the gene that codes for a compete for advancement and/or career changes to leadership bone protein called biglycan. The animals positions that are primarily administrative or managerial. form less bone than their normal counter­ Valeria Shropshire (below, c) a member of the MCP class of 1998, traveled from NIEHS's campus in North Carolina to '- parts, and eventually develop bone receive her certificate. Congratulating her are Steve Benowitz, director of NTH's Office pathology similar to that observed in of Human Resources Management, and Dr. Rieth Kirschstein, NIH deputy director. osteoporosis patients. The 1998/99 MCP is now The animal model is significant in two recruiting employees at grades respects-it identifies a gene that may be a 12, 13 or 14, who have been in a risk factor for developing osteoporosis, career or career-conditional full­ and it provides a new testing ground for time appointment for at least 1 potential osteoporosis therapies. The year prior to Dec. 4, 1998. study appeared in the September issue of Application packages are available online at http://www­ Nature Genetics. urc.od.nih.gov/dwd/mcp or by Osteoporosis is a disease marked by interoffice mail (to request a gradual bone loss and affects about 25 mailing, call DWD at 496-6211). million Americans, 80 percent of whom Completed applications are due are women. Postmenopausal women are by close of business Dec. 4. For particularly susceptible because dimin­ more information, contact ished estrogen levels speed up bone loss. Pauline Irwin, 402-3385 or email j., irwinp@odepsml .od.nih. gov. PRUSINER, CONTINUED FROM PAGE 1

fighting in Southeast Asia") speaking on a hot topic, apart. I guess that's why I didn't know about their and the proud reunion of senior staff (NIH deputy work." That comment drew chuckles from a crowd director Dr. Ruth Kirschstein welcomed Dr. Joe recently saturated in the campus-wide Research Gibbs of NINDS-who helped lay the foundation Festival. for Prusiner's groundbreaking studies-with an Self-deprecating, low-key and funny, Prusiner open-armed hug) who played a role in the speaker's presented a dense analysis of prion activity at the success. molecular level, positing five sites of possible At precisely 3 p.m., Prusiner, bearing a tall diet cola treatment "interdiction" for a deadly pathogen that and sporting he first saw evidence of in a 60-year-old woman a thick back in 1972. Those who missed his talk on Oct. 14 cumulus of were able to see a rebroadcast on video Oct. 21 in white hair, Masur that included everything but the warm blush walked into of the crowd.-Rich McManus Ill the hall with ~ NIA director Osteoporosis Resource Center Funded Dr. Richard ~ The NIH Osteoporosis and Related Bone Hodes who, Diseases-National Resource Center, which will upon amass, develop and disseminate information on a arriving at variety of bone disorders, was funded recently under the reserved a cooperative agreement with a consortium of three seats down voluntary organizations by the National Institute of front, joked Arthritis and Musculoskeletal and Skin Diseases and to a col­ six other agencies within HHS. league along The agreement maximizes the government's Prusiner (1) a11d the lines of, "And you thought we'd have trouble osteoporosis and related bone disorder outreach NIA director Dr. filling the hall?" efforts by linking with those of the National Os­ Richard Hodes Prusiner then launched into a talk-"Prion Biology teoporosis Foundation, the Paget Foundation for share a light and Diseases: A Saga of Skeptical Scientists, Mad Paget's Disease of Bone and Related Disorders and moment before Cows, and Laughing Cannibals"-that liberally the Osteogenesis Imperfecta Foundation. In addi­ the Mahoney credited his mentors, chiefly HLBI's Dr. Earl Lecture on Oct. tion to NIAMS, partners include NICHD, NIDR, 14. Hodes Stadtman and IMH's Dr. Louis Sokoloff, as well as NIEHS, NIA, the Office of Research on Women's a host of current NIH scientists including Drs. Ellis reported that the Health and rhe HHS Office of Women's Health. Kempner, Reed Wickner, Bruce Chesebro, Byron /ectttre's name­ First-year funding of this 5-year agreement totals Caughey and others whose work is advancing the sake, NIA $600,000. field. benefactor "With the 'graying' of our population, we may be Florence "I consider NIH my second scientific home," said staring at a steep rise in hip and other fractures," Stephenson Prusiner, now professor of neurology at the Univer­ said NIAMS director Dr. Stephen Katz. "Better Mahoney, is sity of California, San Francisco. He said he diagnosis, treatment, and especially prevention of approaching her received "a really great education" at Stadtman's lab osteoporosis are clearly needed. The resource 100th birthday in in Bldg. 3 that included three major lessons: "First, April. center's educational potential in this task is enor­ Earl taught me how to do simple experiments ... mous." then, when you get a result, you have to prove it The center, headquartered in Washington, D.C., five, six, seven, eight different ways, not just one­ was first established 5 years ago in response to PHOTOS: ERNIE that's the second thing Earl taught me to do. Third, BRANSON congressional interest, and will be led by Dr. Bess I learned to write scientific papers ...The challenge is Dawson-Hughes of Tufts University, a bone endocri­ to delineate not only what you know-everyone nologist and osteoporosis expert. It will carry out a does that-but also what you don't know. Explicitly national educational and information program. The stating what is uncertain allowed me to describe [the center can be reached at (202) 223-0344. Ill causative agent in scrapie]." Ironically, Prusiner, whose prizewinning studies of FAES Concerts Set, Nov. 8, 15 prions (a new class of pathogens that replicate without DNA) was built on work done at NINDS by The FAES Chamber Music Series will present the Gibbs and fellow Nobel laureate Dr. Carleton Vienna Virtuosi at 4 p.m. on Sunday, Nov. 8 in Gajdusek (who studied kuru and scrapie), says he Masur Auditorium, Bldg. 10. On Sunday, Nov. 15 "learned nothing about kuru at NIH" during his at the same hour and venue, FAES presents Trio di tenure as a clinical associate. "That's because Joe Parma. Tickets for each concert are $20 at the door; Gibbs and Carleton Gajdusek worked in Bldg. 36, $10 for students and fellows. For more information and I was in Bldg. 3, which are a very great distance call 496-7975. I Thrift Savings Plan Open Season Wednesday Afternoon Lectures The Thrift Savings Plan is having another open season from Nov. 15, 1998, through Jan. 31, 1999. The Wednesday Afternoon Lecture series­ FERS employees who were hired before July 1, normally held on its namesake day at 3 p.m. in 1998, as well as CSRS employees have an opportu­ Masur Auditorium, Bldg. 10-switches to nity to change their current election, or make an Monday on Nov. 9 when Dr. James Watson gives Dr. Arnold initial election. the first Stetten Museum/NHGRI History of Revzin has Eligible FERS and CSRS employees may elect to Genetics Lecture, "From the Double Helix to the recently become a contribute to the G fund (government securities), C Human Genome Project." Time remains 3 p.m., scientific review fund (stocks), and/or F fund (bonds). FERS employ­ as does venue, Masur. Watson is president, Cold administrator at Spring Harbor Laboratory, New York. the Center for ees may contribute up to 10 percent of their salary Scientific Review. each pay period and will receive matching agency A special Thursday lecture will be held Nov. 12 at 3 p.m. in Masur when Dr. Philip A. Beachy He is in the contributions on the first 5 percent. CSRS employ­ biophysical and ees may contribute up to 5 percent of salary, but do discusses "Hedgehog Protein Biogenesis and chemical sciences not receive any matching contributions. FERS Signaling." He is professor, department of initial review employees who do not contribute receive an auto­ molecular biology and genetics, and HHMI group, and will matic 1 percent agency contribution each pay associate investigator at Johns Hopkins Univer­ be involved with period. They may choose to distribute this among sity School of Medicine. reviewing the three funds. On Nov. 18, Dr. Carol L. Prives, professor, program project, The features of the plan and directions on how to department of biological sciences, Columbia research resource, University College of Physicians and Surgeons, and instrumenta­ make a plan election or to change your current tion applications, withholding are described in the Thrift Savings Plan gives the NIH Director's Margaret Pittman Lecture: "Signaling to the p53 Tumor Suppressor along with small Open Season leaflet, which will be distributed to business innova­ eligible employees by their IC personnel office. Protein." tion research More detailed information is provided in the For more information or for reasonable accom­ grant proposals. Summary of the Thrift Savings Plan for Federal modation, call Hilda Madine, 594-5595. He spent the past Employees booklet and is available in your IC 23 years at personnel office. Iii Michigan State University, where Tool Available for Selecting Health Plan he advanced through the ranks to full professor Decision Innovations, Inc., a health care technology Annual Leave: Use It or Lose It company, has created a Web-based decision support in the department tool for federal employees selecting health plans. Annual leave in excess of the maximum carryover of biochemistry. NIH's Office of Human Resource Management, balance (in most cases 240 hours) is normally His research specialties are in Work and Family Life Center, and OPM have joined forfeited if not used by the end of the current leave year. If you have not already planned to take those the area of the forces to acquire access to PlanSmartChoice, which physical biochem­ will be available to all federal employees in five excess hours of annual leave, you should discuss istry of DNA­ locations: Maryland, Pennsylvania, Virginia, the your leave with your supervisor now while there is protein interac­ District of Columbia, and North Carolina. still time to schedule it. Your biweekly Earnings and tions, and he is PlanSmartChoice allows users to select health plan Leave Statement tells you how much annual leave well-published in features and benefits that are important to them. you must use so that you will not lose it when the peer-reviewed The program then asks the user to rate these at­ leave year ends on Saturday, Jan. 2, 1999. journals. While tributes and make some trade-off decisions. As the In spite of planning, circumstances sometimes arise at Michigan State user goes through this exercise, the software builds a that prevent you from taking leave that has been he developed the "electrophoretic profile of that person's needs and preferences. It scheduled and approved earlier during the leave year. In such cases, you and your supervisor are mobility shift then matches this "preference profile" to all plans assay," which is available in that individual's zip code. jointly responsible for ensuring that any "use or now widely used PlanSmartChoice shows the users every plan avail­ lose" leave is rescheduled in writing. This year, your in studies of use or lose leave must be scheduled in writing not able and, in priority order, tells which plans best many nucleic ii match their needs. The tool then allows the user to later than Saturday, Nov. 21. acid-protein compare any available plans in a matrix. Should you or your supervisor have questions systems. PlanSmartChoice will be available to NIH'ers regarding use or lose leave, contact your human =•ii during Open Season through the www.OPM.gov/ resource office or other official designated by your - ii institute or center. . insure Web site, under the button "Help Me Choose Iii a Health Plan." It will also be available directly through www.PlanSmartChoice.com/FEHBP. Iii II! 91! J FESTIVAL, CONTINUED FROM PAGE 1 postures of predicament as they scanned the glossy 83-page menu of choices, brows knit in concentra­ tion. What if, by chance, you were interested in both "Characterization of Biologic Mediators by Spectroscopic Methods" and "Gene Regulatory Proteins," both fighting for your attention from 10:30 a.m. to half past noon on the festival's last day? Attendees sometimes solved the problem by flitting from room to room, finding some dark­ ~ide," whi_ch _offer~d hope for the still-living, ened by slide projec­ mcludmg insights into AlDS pathogenesis and tions, others ham­ ~ description of a new pered by misbehaving ., vaccine to prevent The NIH sound systems. By the third and final day of the severe diarrhea in Chamber Singers fest, technicians handling lights and sound were no infants and youngsters. (above) enter­ For those addled by longer masking their frustration as they bustled to '' tained in the please lengthy rosters of the possibi_lities, there picnic tent on the presenters. were massive tents first day, followed outside the Natcher by Scott Durum's The lead copies them­ selves could produce center offering diver­ rock trio from ' anxiety. The plenary sions of a sort: on the NCI on day 2, southeast side were and the sessions kicked off Paulverizers, led Wednesday, Oct. 6 with two rencs housing the Technical Sales Association's byNIMH's speculations on cosmol­ annual exhibit of sciencific equipmenc, and to the Charles ogy and the origins of northwest sat a picnic tent, .me 1u d.mg a stage \ ~-,..., ~•~-~-•---...-• . Havekost, on day life, introduced by NASA 1 3. It was an all­ Administrator Daniel where some intramural intramural music Goldin. The final performers encerrained. fest. plenary session Friday The TSA tencs were a swarming bazaar of was on apoptosis-programmed cell death-and PHOTOS: ERNIE included detailed description of molecular "death sciencific supplies BRANSON, RICH presenced by a slew of MCMANUS domains." Concluding a discussion of ALPS­ autoimmune lymphoproliferative syndrome­ manufacturers, each NIAID's Dr. Stephen Straus quoted Ecclesiastes: offering such freebies as A symphony of "For everything there is a season, and a time for dishes full of hard candy, gestures and pens, coffee, mousepads, expressions helps every matter under heaven: a time to be born and a time to die." ' drink cups, and raffle Seventeen-month-old Karl convey the chances on items ranging But that sentiment, combined with leaden skies for Philip Mellen was one of content of the from cell phones to posters in the two of the festival's three days, did nothing to the younger attendees at Polartec fleece outerwear. series of photos dampen the enthusiasm of attendees one of whom poster day. His mom is Almost everyone trekking NIAID's Kimberly D. Dyer. below and at 1;1IH d~ector D~ Harold Varmus, e;ited the apopt~­ right. s1s sess10n beammg and waving, invigorated, not back to their labs on bedimmed, by his en­ campus after a trip to Research counter with the biologi­ Festival bore a plastic shopping bag stuffed with giveaways. cal enforcers of cells' demise. Organizers called the twelfth Teetering, perhaps festival a success and are unironically, between the already critiquing their efforts opening session on life's in preparation for lucky 13, a cosmic origins and the 3-day swath of fall 1999 final, apoptotic (if not wherein the Yellow Sheet gets apocalyptic) session, was carried, once again, to the 10th "Insight from the Bed- power.-Rich McManus Iii BOWMAN, CONTINUED FROM PAGE 1 buy just one of the two he needed. Undaunted, Bow­ ii Bowman's widow, Alice, and family members man contacted sources in his network of instrument ii• attended the symposium, part of NHLBI's yearlong manufacturers and junk shop scavengers back in New ii 50th anniversary celebration. York. They sent him a Steinheil quartz prism spec­ Two of the symposium's organizers, Drs. Robert trograph that had been "liberated" from Germany • Berger and Jay Knutson, worked closely with Bowman during the war, and he used parts of it to build the •i on research instrumentation design in NHLBI intramu­ second monochromator at considerably lower cost than ii ral laboratories. The third, NIH historian Dr. Victoria the grating. Harden, interviewed Bowman before his death and Other wartime instruments also conducted the historical research for the exhibit. found their way into the SPF. Harden is also director of the DeWitt Stetten, Jr., Bowman chose a xenon arc lamp Museum of Medical Research, which cosponsored the from a German searchlight as the exhibit and symposium with NHLBI. source because it provided a "The story of the SPF reveals the serendipitous path of nearly continuous spectrum far medical research," said Harden. The spectrophoto­ into the UV region. Photomulti­ fluorometer was originally designed to quantitate plier tubes, modified during the antimalarial drugs, but its commercialization in the war as high-noise generators to 1950's has led to innumerable contributions in protein jam enemy radar, had originally been designed for high­ Attending the and DNA research. Harden added that one of her most sensitivity, low-noise light amplification. When substi­ ribbon-cutting important resources for the historical exhibit was tuted for the more common vacuum tubes, they greatly ceremony for the enhanced UV fluorescence detection. AMINCO­ Bowman's early notes on instrument design. "Hold Bowman onto your laboratory notebooks," she cautioned The optics were stuck to a benchtop with wax and Spectrophotofluor­ symposium attendees. used successfully for in-house experiments. Soon the ometer exhibit In his keynote address, Dr. Robert Berliner, former SPF attracted the attention of the American Instrument outside Lipsett NIH deputy director for science, explained how Co. (AMINCO), which cooperated with NIH to bring it Amphitheater in Bowman came to invent the SPF. Although Bowman into commercial production and marketed it success­ Bldg. 10 are had served in the medical corps during World War II, he fully to laboratories nationwide. (from l) Alice was more interested in designing and building instru­ Since then, new optical configurations and fluorescent Bowman, widow ments to solve research problems. He kept a full-scale dyes, coupled with advances in computing, have of Dr. Robert L. Bowman; former machine shop in his basement at home and had a great spawned an incredible variety of UV-visible fluorescence techniques. Symposium speakers presented recent NIH deputy appreciation for the hidden potential of spare parts. In director for later years, his love of salvaged equipment led to the work, including time-resolved spectrofluorometry, science Dr. acquisition of a Norton bomb sight and the inclusion of which permits observation of molecular flexibility and Robert Berliner; periscope prisms recovered from army tanks in some of interactions between proteins, membranes and DNA NHLBI Division his spectroscopic inventions. molecules; and two-photon fluorescence microscopy, of Intramural Just after the war, Bowman joined Dr. James which provides sharp confocal images and allows 3-D Research director Shannon's research team, which included Berliner, at optical reconstruction of cell contents. One of the more Dr. Edward Korn; Goldwater Memorial Hospital in New York. The SPF eye-popping new developments is the use of green NHLBI deputy grew out of the laboratory's wartime research on fluorescent protein (GFP) gene expression in transgenic director Dr. John antimalarial drugs. One colleague, Dr. Bernard B. animal models as an internal fluorescent "tag" for a Watson; and NIH protein of interest. Production and migration of the Historian and "Steve" Brodie, was using the Coleman filter fluorom­ De Witt Stetten, GFP-coupled protein can be monitored in tissues and eter to measure quinine concentrations in plasma, but Jr., Museum of many candidate drugs were undetectable in the visible cells, and as an added benefit, GFP gene splicing makes Medical Research region. A few had been reported to fluoresce in the it easy to tell transgenic and control mice apart-the director Dr. ultraviolet, but at the time, commercial UV fluorom­ transgenic mice turn bright green under a UV lamp. Victoria Harden. eters were nonexistent, and even quartz optics were Perhaps what survives most in the memories of scarce. Bowman, Brodie, and Sidney Udenfriend Bowman's successors and former students is his cheerful decided to build a practical fluorometer that would hands-on approach to analytical problems. Knutson span the UV and visible regions. When Shannon remembers a typical incident. "I was hired by Dr. moved to NIH, they followed, and in the early 1950's, Bowman and Ray Chen as a staff fellow in 1984. A few Bowman designed the prototype. weeks after I arrived, Dr. Bowman appeared in my lab The standard visible-range fluorometer demanded a with an imposing piece of optical equipment mounted in separate filter for each wavelength of interest. Such a a large aluminum box. It was secured by dozens of design would be prohibitively expensive for UV work, screws, all covered with a label that said "DO NOT because no one knew which wavelengths were critical. OPEN! NO USER SERVICEABLE PARTS INSIDE." UV grating monochromators had just come on the He asked me what that meant. I paused a moment, market, but they cost $5,000 apiece-about $100,000 then declared "We open it!" He straightened up with a in today's money. Shannon originally denied the big smile and proclaimed, "You pass the test! We'll get purchase, but later relented and allowed Bowman to along just fine." Iii ADVENTURE, CONTINUED FROM PAGE 1 Many people electricity and magnetism, optics and telescopes, believe the human and animal anatomy, DNA and genetics, and AIS program microscopic life. and others The droves of excited young participants who like it have the come to these Saturday workshops have already potential to shown evidence of a burgeoning interest in scientific transform careers. Margaret Dunham, a 12-year-old who has textbook participated in the program for the past 2 years, memorization claims it has had a tremendous impact on her career assignments plans. "I didn't know much about science before I into vibrant started; my friends and I wanted to be actors like in experiences of the movies," she says. "Then I started AIS and it discovery, and shifted my goals. It made science appear fun to me to make kids Paul Su and Sean Kelly test principles for the first time." want to of architectural physics using straws, Originally conceived in 1973 by Dr. Ralph Nash, a pursue science rubber bands and paper clips. NASA scientist who wanted to make science more as a career or exciting for his young daughter, the Adventure in at least as fun exploration. One such believer is Dr. Science program attempts to give science new life for Bruce Fuchs, director of the NIH Office of Science students by allowing them to participate actively in Education. "One of the most important aspects of science demonstrations and experiments. The the program is that it can have an impact of im­ program has grown phenomenally from its modest mense proportions on kids, since many of them do beginnings in Nash's basement, and now includes not perceive science as fun," he says. "The neat approximately 180 students who take classes thing about AIS is that each Saturday kids get concurrently at four sites every Saturday. Three of together with adults who are engaged and excited the sites are devoted to students ages 8 through 11: about science. The adults are having fun with their NIH, Bechtel in Gaithersburg, and work and the kids are reaping the Comsat in Clarksburg, Md. The benefits." fourth site, the National Institute of Many of the AIS teacher­ Standards and Technology in volunteers agree that the best part Gaithersburg, is for students ages of teaching is the opportunity to 12 through 15. The NIH site work with enthusiastic, highly enrolls 30 to 50 students each year. motivated students who are eager Many see the program as a much­ to learn. "For me the best part is needed tool to raise students' seeing kids get the concept of how interest and achievement in science. a chemical assay works," says Dr. The hands-on structure enables Steven Bauer, a scientist at the Tonya Torres and Yasmeen Brown young people to experience science measure the vitamin C content of Food and Drug Administration firsthand and make their own sample foods and beverages. who has taught in the program for discoveries. "These sessions need about 5 years. Bauer, whose class to be 'minds-on' and not just hands-on," says Dr. teaches how to measure the amount of vitamin C in Edward Max, who manages the NIH site along with foods and beverages, sees the program as an excel­ Blanche O'Neill. "We want to promote lessons that lent opportunity for young people to gain practical Kristen Seaman actively involve the kids' thinking." science and math skills. "The students like it learns how to By engaging children's minds in scientific inquiry, because it's hands-on, they get to measure the pipet DNA with the program can provide just the sort of impetus amount of vitamin C in things like orange juice and a little help from that many educators believe may begin to address HiC, and they learn how to do quantitative analysis Dr. Kathy Kelly. the deficiencies in U.S. students' performance in the and look at data from their experiments." sciences. According to the results Dr. Allen Barnett, a physicist at the National of the Third International Math­ Institute of Neurological Disorders and Stroke, ematics and Science Study, U.S. voices a similar sentiment: "The AIS classes excite students' knowledge in the kids' interest in science, get them interested and physical and life sciences declines make them ask questions about the world around rapidly as they progress from 4th them." He teaches two classes: one in magnetic through 12th grade. The study resonance imaging and the other on polarized light. suggests there is a need to find And while he finds the experience enjoyable, he is better ways to sustain young sometimes plagued by the challenges and limitations people's interest in science as they of being a volunteer educator. "I enjoy doing it, but advance through secondary school. the major difficulty is my inexperience with kids, not - --====--:-:===-----===,-----:::::s--.

knowing what to expect them to understand at Meeting on different levels," he explains. Gene Therapy Courses and Seminars Most volunteers overcome such obstacles through li,j CIT for Arthritis experience and find that the rewards of teaching in All courses are on the NIH campus and are given the AIS program outweigh the occasional challenges. without charge. For more information call 594- Gene Therapy of Dr. Christine Kozak, a section head at the National 3278 or consult the training program's home page at Arthritis and Institute of Allergy and Infectious Diseases, teaches http://livewire.nih.gov. Related Disorders a course on telescopes and optics. She considers the 1st International program's greatest asset to be its impressive array of Year 2000 Concerns for Researchers Meeting w ill be volunteer teachers. "The teachers have a wide range and Clinicians · 11/5 held Dec. 2-3 at of interests and expertise," she says. "I love to sit in NIH Data Warehouse Travel Mini Session 11/5 the Natcher on other classes when I'm not teaching my own. I Parachute Startup for Windows 95/Windows98 11/6 Conference Center. LAN Services and Email from Parachute 11/6 think the teachers make the subjects interesting." Organizers include NIH Data Warehouse Procurement Dr. Chris Evans of The classroom is not the only place students get & Market Requisitions Mini 11/6 the University of exposed to outstanding scientists and researchers. DB2 and Oracle Data Definition, Control, Each year, the program culminates with a Parents' and Advanced Manipulation 11/9-10 Pittsburgh and Dr. Day/student recognition event in mid or late March, WIG - World Wide Web Interest Group 11/10 Susana Serrate• when the students PC Hardware Concepts and Usage 11/12 Sztein, NIAMS. present their projects Troubleshooting PC Hardware 11/12 The meeting w ill to parents and invited NTH Data Warehouse Advanced GQL 11/12 convene a group guests. This is their NIH Data Warehouse Research Contracts of international time to shine: the and Grants Mini 11/12 scientists working Producing Tables with SAS 11/13 young scientists on the develop­ Applied Statistics and the SAS Programming ment and astound their audience , Language 11/12-13 with creative visual PC Hardware Concepts and Usage 11/13 application of displays and in-depth Troubleshooting PC Hardware 11/13 gene therapy descriptions of Oracle SQL Plus 11/16-17 technologies for comple~ scientific Margaret Dunham gets up C Language Fundamentals 11/16-20 the treatment of mechamsms that often close and personal with a live Oracle PL/SQL for Application Developers 11/18-19 arthri1is and boggle the minds of chick embryo that has just been Introduction to the Macintosh Operating System 11/20 related disorders. adults. Another released from an egg. NIH Data Warehouse Procurement highlight of the event & Market Requisitions 11/20 The deadline for Database Technology Seminar 11/20 is the keynote address given by a prominent scientist submitting in the physical, life or Earth sciences. In previous abstracts is Nov. 6, years, guest speakers have included two Nobel Prize DWD Training Tips and the registra­ winners in physics-Clifford Shull and William The Division of Workforce Development (DWD), tion deadline is Phillips, who won the 1994 and 1996 prizes respec­ OHRM, will offer the courses listed below. Hands­ Nov. 20. NIH'ers tively, and Joel Achenbach, a former staff writer for on, self-study, personal computer training courses are not required to the Washington Post who is best known for his are available through the DWD's User Resource pay the registra• "Why Things Are" column. Center at no cost to NIH employees. For details, tion fee, but w ill Becoming an AIS volunteer instructor is easier than visit DWD online at http://www-urc.od.nih.gov/ be asked to pay one might think. Prospective instructors must meet dwd/dwdhome.html or call 496-6211. $15 for food and beverage. For only two criteria: they must be able to communicate Administrative Systems information and to the fun and excitement of science, and they must Travel for Administrative Personnel 12/1 enjoy working with children. AIS volunteers need Domestic Travel 12/7 register, call Dr. not be scientists or even NIH employees. Basic Time and Attendance Using ITAS 12/9 Joan Chapdelaine "Science didn't appeal to me at first because it was Foreign Travel 12/10 at (717) 585-2211, all textbooks, and textbooks are just a weight in my fax (717) 585-2383. Career Transition For the prelimi­ backpack," Margaret Dunham explains. "Now it's NIH Retirement Seminar - CSRS 12/8 something real that I can use, and l enjoy it." The nary agenda, see fact that AIS could change her mind, and the minds Computer Applications and Concepts the NIAMS Web of other young people like her, makes this a program Introduction to Corel WordPerfect 8.0 12/1 site at http:// Introduction to Windows 12/3 that might be worth checking out. www.nih.gov/ Upgrading to Windows 98 12/8 A variety of volunteer opportunities are available. niams/ news/ If you are interested in finding out more about the genet hp.htm. Adventure in Science program or would like to become a volunteer, call Dr. Edward Max at (301) 827-1806. Iii Aldrich, First NICHD Director, Dies Dr. Robert A. " Bob" Aldrich, NICHD's first the University of Minnesota hospitals, and served director, died on Sept. 16 at age 80 from complica­ from 1949 to 1951 as an associate and consultant tions of diabetes. He served as NICHD director in the section on pediatrics of the Mayo Clinic. from March 1963 to October 1964. After teaching pediatrics at the University of "During his brief tenure here, Dr. Aldrich helped Oregon, he moved to Seattle to chair the University chart the course for the NICHD," said Dr. Duane of Washington Medical School's department of Alexander, current institute pediatrics in 1956, where he remained until director. "I am deeply becoming NICHD director. saddened by this loss and After leaving N ICHD, he returned co the Univer­ offer my sincere condolences sity of Washington Medical School in 1964, to head to his friends, family and the division of health resources and serve as colleagues." president of the university's faculty senate in 1968. In 1962, Aldrich was asked In 1970, he became vice president for health affairs by the Kennedy administra­ at the University of Colorado, then returned to the Auction tion to help found and staff University of Washington in 1980 co work in the Donations NICHD. While at the Graduate School of Public Affairs. Sought institute, Aldrich helped Dr. Robert Aldrich He is perhaps best known for founding the establish NICHD's research organization "KidsPlace," dedicated to making The Clinical Center centers on the prevention and treatment of congeni­ cities more hospitable to the needs of children. He department of tal and acquired disorders that cause mental also wrote on the topic of making classrooms more clinical pathology retardation and other disabilities. suited to children's needs. has hosted a "The new institute is one of the most sophisti­ Aldrich was also an avid camper and sceelhead holiday fund-raiser cated efforts any nation has ever made in studying angler. He is survived by his wife of 58 years, auction to benefit the progress of growth," Aldrich said in a February Marjorie Aldrich, his sister, Cynthia Rowe, his the Patient 1963 article in the Seattle Post Intelligencer. brother Stephen Aldrich, two sons, and eight Emergency Fund Born in Evanston, Ill., he graduated from Amherst grandchildren. and Friends of the College in 1939, and received his doctor of medi­ Memorial contributions can be made to the Clinical Center for cine degree in 1944 from Northwestern University. Aldrich Professorship, Department of Pediatrics, 26 years. NIH'ers After 2½ years in the U.S. Navy during the Second University of Washington School of Medicine, 1959 are asked to World War, Aldrich served 3 years as a resident at N.E. Pacific Street, Seattle, WA 98195. volunteer their services or donate Open Season for FAES Insurance items to this Fellowships Offer Opportunities for Research annual event. All The FAES Health Insurance Program is holding an donations are tax open season Nov. 2-25. The program is open to in Japan, Deadline to Apply is Jan. 15 those who work for or at NIH in full-time positions deductible. This Through arrangements made with the Fogarty but are not eligible for government plans. This year's version will International Center, the Japan Society for the includes NIH fellows, special volunteers, guest be held Friday, Promotion of Science (JSPS) is offering fellowships researchers, contractors and full-time temporary Dec. 4 in Bldg. 10, for American researchers in the biomedical and personnel. The minimum enrollment period is 3 Rm. 2C310 behavioral sciences to pursue collaborative research months. Open season is for those who did not enroll conference room in Japanese universities and other eligible institutions and library. A when first eligible and for current subscribers to make changes. FAES offers two programs this year: and laboratories. coffee and bake The JSPS Short-term Fellowship provides for sale begin the Blue Cross/Blue Shield Select Preferred Provider Plan, and Innovation Health, a health maintenance research visits of 7 to 60 days; the JSPS Short-term event at 9 a.m., Postdoctoral Fellowship provides for research visits followed by a organization. Information about rates and benefits, effective Jan. 1, 1999, may be obtained from the of 3 to 11 months. Applicants must be U.S. citizens silent auction and or permanent residents and research plans must be FAES business office, Bldg. 10, Rm. BlC18. El white elephant arranged in advance with the Japanese host. The sale at 11, and NCMA Holds Seminar application deadline is Jan. 15, 1999. pizza on sale at Full announcements, application instructions and 11:30. The silent The Bethesda/Medical chapter of the National more information may be found on the FIC Web site auction ends at 2 Contract Management Association is hosting a at: http://www.nih.gov/fic/opportunities/ p.m. To make "FAR Part 15 Rewrite Seminar" on Tuesday, Nov. ff.html#japan. Information is also available from donations call 10 from 8:30 a.m. to 5 p.m. in Natcher Conf. Rm. Dr. Kathleen Michels at email: [email protected], fax: Sallie Seymour, C 1/2. Speakers include Melissa D. Rider, Depart­ 402-0779. El 496-3386, or ment of Defense, and Ida M. Ustad, General Services Norma Ruschel!, Administration. Registration is required. For more 496-4473. information call Karen Padmore, (301) 299-8655. Ill Research Pioneer Huebner Mourned The NIH community mourns the passing of Dr. risk taker. He was always willing to take huge leaps Robert J. Huebner, a pioneer contributor and to gain scientific knowledge. He had an open mind award-winning scientist who helped shape research and would listen to anyone who had an idea, no agendas in virology, microbiology and epidemiology matter what station in life that person might hold. during a distinguished 40-year career in the Public That kind of scientist is rare." Chanock was hired Health Service at NIH. Huebner, who had suffered by Huebner in 1957 and succeeded him as labora­ from Alzheimer's disease for 16 years, died on Aug. tory chief in 1968. 26 in a hospital in Coatsville, Pa. He was 84. He "He made sure he had people in the laboratory had been in a Pennsylvania nursing home since who could fill in the gaps," adds Dr. Janet Hartley, 1991. who also came tO NIAID in 1953 under Huebner's "We are saddened by the death of Dr. Huebner," tutelage. "His knowledge and his unshakable belief said NIAID director Dr. Anthony Fauci. "Under his in the promise of science inspired many young NIAAA's Keller leadership, the scientists during his long NIH tenure. The list of Lecture, institute's Laboratory people he mentored forms the nucleus of science Nov. 19 of Infectious Diseases departments and medical institutions all over the became a world center world-in Europe, Japan, Taiwan, Korea, Israel and The t hird annual for discovery and Turkey." M ark Keller investigation of Huebner was the recipient of the Presidential Honorary Lecture respiratory tract National Medal of Science, the PHS Distinguished Series w ill be held viruses and for the Service Award, the Rockefeller Public Service Award, Thursday, Nov. 19 study of the oncogenic the Kimble Methodology Research Award and the from 1 :30 to 3:30 potentials of certain Pasteur Medal. He was elected to the National p.m. in M asur viruses. He was Academy of Sciences in 1961 at a time when bio­ Auditorium, Bldg. consistently in the medical scientists were significantly under-repre­ 10. Dr. ling-Kai Li, forefront of the search sented in the academy. distinguished for the basic causes of Survivors include his wife, Harriet of Rockville, professor and disease." Md., 8 children and 11 grandchildren; 3 brothers associate dean for Huebner left NIAID Dr. Robert Huebner and 4 sisters. Iii research, Indiana as chief of the Laboratory of Infectious Diseases in University School 1968 to become chief of NCl's Laboratory of Viral of Medicine, is this year's award Carcinogenesis. Attent ion All NIH Fellows A native of Ohio, he earned his medical degree recipient and from St. Louis University School of Medicine in Did you know that NIH has a graduate school lecturer. His 1942. During World War II, he joined the Public on campus? It's part of the Foundation for speech is entitled, Health Service as a medical officer and served on a Advanced Education in the Sciences-FAES. "Pharmacogenet­ Coast Guard vessel in Alaska. Did you also know that NIH fellows are encour­ ics of Responses During his career at NIH from 1944 to 1982, aged to teach courses at FAES? to Alcohol and Huebner helped isolate and describe many impor­ This is an excellent opportunity to share your Genes That tant microbial causes of human disease. He isolated knowledge with the NIH community. FAES Influence Alcohol the etiological agent and defined the epidemiology offers a broad range of courses that you can Drinking." For and natural history of rickettsialpox; conducted teach, from basic and clinical sciences to lan­ more information, important studies of the epidemiology and transmis­ guages and photography (for a complete list of see the NIAAA sion of Q fever; and defined coxsackie A viruses as FAES courses, visit http://faes.org/ W eb site at: http:/ the causative agent of herpangina. academic.htm). /silk.nih.gov/ With his colleagues, Huebner discovered and The FELCOM subcommittee on teaching is silk.niaaa1 / defined the hitherto unknown adenoviruses group prepared to help those interested in teaching, conference/ and devised a unique concept for an oral, enteric­ whether you'd like to teach an entire course keller.htm. coated, live virus vaccine that proved highly protec­ yourself or be a guest lecturer. To add your tive against disease caused by adenovirus type 4 and name to the list of possible instructors, email type 7. He also explored viruses that cause cancer Kathleen Kerr ([email protected]) with your areas in animals in research that stimulated his formation of interest. FELCOM will use this list to of concepts that led to the present understanding of organize ideas for teaching opportunities for fall oncogenes. 1999 and spring 2000 semesters at FAES. "We "Working with Dr. Huebner was extraordinarily will be making suggestions to groups of fellows exciting," recalls Dr. Robert Chanock, chief of the with similar interests and supplying possible Laboratory of Infectious Disease in NIAID's Divi­ guest lecturers," Kerr said. sion of Intramural Research. "Dr. Huebner was a Past, Current Directors Speak At NIA ID's 50th Anniversary

dvancing Knowledge and Impr~ving Heal~h" is NIH Funds Support Nobel Laureates A the theme of NIAID's 50th anmversary scien­ tific symposium to be held on Thursday, Nov. 19 The three 1998 Nobel laureates in physiology from 9 a.m. to 5 p.m. in Natcher Conference Center or medicine- Drs. Robert Furchgott, Louis auditorium. All NIH staff are invited. Distin­ Ignarro and Ferid Murad-all enjoyed, like guished investigators from NIH and elsewhere will many of their predecessors,. yea_rs of ~I~ grant speak about cunent knowledge and future research support for their prizewinnmg mv~stI~ations: goals of the major emphasis areas ~uppo_rted by The trio were recognized for basic d1scovenes NIAID-allergy, immunology and mfect1ous about nitric oxide, a gas the body uses in many diseases. physiological functions ranging from dil~ting NIH deputy director Dr. Ruth Kirschstein will blood vessels (its actions led to the creation of Viagra to treat impotence), to regulating blood open the event with welcoming remar½s, NI~ID . director Dr. Anthony Fauci will then give a h1ston­ pressure, to sending signals to the nervous system. cal perspective of the institute's research accom­ Furchgott, 82, is distinguished professor of plishments. Dr. Richard pharmacology at the State University of Ne~ Krause, senior scientific York Health Science Center at Brooklyn. His advisor of the Fogarty first NIH grant was in 1958, from the National International Center and Institute of General Medical Sciences, and he immediate past NIAID remains a grantee today, from the National director, will speak on Heart, Lung, and Blood Institute. NIH grant "Microbes Evolving and data indicate Furchgott and his collaborators Emerging Infectious Diseases: have received some 67 awards, mainly from The Compulsion to Become NHLBI, but also including NIGMS and what is nowNINDS. Something New." Following Krause, Dr. Jeffrey Bluestone, Ignarro, 57, is at the University _of California_, the Virginia and D.K. Los Angeles. His NIH funding history began m Ludwig professor at the 1967 with an award from NHLBI to study the University of Chicago, will "biochemical nature of adrenergic receptor address "Organ-Specific sites." He and his team have won a total of 44 Tolerance: Achieving the awards, again chiefly from NHLBI, though also Holy Grail of Transplanta­ including what is now NIAMS, and NICHD. tion!" The morning program Murad, 62, now at the University ~f Texas Dr. Richard will end with Dr. Robert Gallo, director of the Health Science Center at Houston, first won an Krause (I), University of Maryland's Institute of Human . NIH grant in 1974 while at the {!niversitf of NIAID's fourth Virology in Baltimore, giving a personal perspective Virginia. The 44 awards made smce to him and director (August on HIV/AIDS research. his colleagues at U.Va., Stanford and Abbott 1975-July 1984) After lunch, Dr. Max Cooper, an investigator with Laboratories have come from NIAMS, NIGMS, appears in this the Howard Hughes Medical Research Institute and NHLBI and NIDDK. 1988 photograph In addition to their funding connection to with the institute's a professor of medicine? pe~iatrics, pathology and microbiology at the Umvers1ty of Alabama at NIH, two of the laureates served on study fifth and present sections: lgnarro was a member of the pharma­ director, Dr. Birmingham, will lecture on "Immune System cology study section during 1982-1985 and Anthony Fauci. Development and Human Well-Being," followed by Dr. Louis H. Miller, chief of NIAID's Laboratory of Murad served the same section from 1984 to Parasitic Diseases who will discuss "The Modern 1987. Pasteurians: Fro1~ Science to Control and Eradica­ Of the 75 American Nobel laureates in tion of Malaria." The program will close with Dr. physiology or medicine since 1945, 56, or more K. Frank Austin, professor of medicine at Harvard than two-thirds, either had worked at or were University, who will address "The Biosynthesis o~ supported by NIH before ~in~ing the priz_e. the Cysteinyl Leukotrienes, Mediators of Bronchial Since World War II, 118 scientists worldwide Asthma," and Dr. R. Gordon Douglas, Jr., president have been awarded the Nobel prize in physiol­ of Merck Vaccines, who will talk about "The ogy or medicine. More than half of them (66) Future of Vaccines: Science, Public Health and had prior support from, or worked at NIH Medicine." before the honor. No registration is required._ Seating is a~ailable on a first-come, first-served basis. For more mforma­ tion, call 496-5717. (j)